Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8fl4_NV.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): VAL 5.A N LEU 317.A O no hydrogen 2.870 N/A ALA 6.A N TRP 21.A O no hydrogen 2.942 N/A VAL 7.A N ALA 315.A O no hydrogen 3.023 N/A CYS 8.A N ILE 19.A O no hydrogen 2.918 N/A THR 9.A N ASN 313.A O no hydrogen 3.100 N/A THR 9.A OG1 THR 312.A OG1 no hydrogen 2.894 N/A SER 11.A N PRO 310.A O no hydrogen 2.996 N/A SER 17.A N TYR 32.A O no hydrogen 2.445 N/A CYS 18.A N TYR 32.A O no hydrogen 3.320 N/A CYS 18.A SG CYS 8.A O no hydrogen 3.733 N/A ILE 19.A N CYS 8.A O no hydrogen 2.838 N/A VAL 20.A N LEU 30.A O no hydrogen 2.817 N/A TRP 21.A N ALA 6.A O no hydrogen 3.141 N/A GLU 22.A N ALA 27.A O no hydrogen 3.035 N/A LEU 23.A N GLU 4.A O no hydrogen 3.228 N/A SER 25.A OG GLU 22.A OE1 no hydrogen 2.702 N/A SER 25.A OG GLU 22.A OE2 no hydrogen 3.326 N/A GLY 26.A N GLU 22.A O no hydrogen 2.971 N/A LEU 29.A N VAL 20.A O no hydrogen 2.641 N/A LEU 30.A N VAL 20.A O no hydrogen 3.159 N/A TYR 32.A N CYS 18.A O no hydrogen 2.926 N/A TYR 32.A OH LEU 65.A O no hydrogen 2.757 N/A ARG 33.A N LYS 68.A O no hydrogen 3.446 N/A GLN 36.A N GLN 54.A OE1 no hydrogen 3.309 N/A GLY 38.A N ALA 53.A O no hydrogen 2.904 N/A ARG 40.A N ASN 313.A OD1 no hydrogen 3.000 N/A ARG 40.A NH1 THR 271.A O no hydrogen 2.923 N/A ARG 40.A NH2 THR 271.A O no hydrogen 2.964 N/A ALA 43.A N LEU 51.A O no hydrogen 2.937 N/A LEU 45.A N TYR 49.A O no hydrogen 2.766 N/A GLU 48.A N LEU 45.A O no hydrogen 3.052 N/A TYR 49.A N LEU 45.A O no hydrogen 3.180 N/A TYR 49.A OH LEU 332.A O no hydrogen 2.816 N/A LEU 50.A N TRP 63.A O no hydrogen 2.863 N/A LEU 51.A N ALA 43.A O no hydrogen 2.794 N/A ALA 52.A N SER 61.A O no hydrogen 3.007 N/A ALA 53.A N GLY 41.A O no hydrogen 2.783 N/A GLN 54.A NE2 ALA 52.A O no hydrogen 3.343 N/A ILE 60.A N ILE 75.A O no hydrogen 3.133 N/A SER 61.A N ALA 52.A O no hydrogen 3.113 N/A SER 61.A OG GLN 70.A OE1 no hydrogen 2.776 N/A TRP 63.A N LEU 50.A O no hydrogen 2.860 N/A LEU 65.A N GLU 48.A O no hydrogen 3.417 N/A GLN 66.A NE2 SER 322.A O no hydrogen 2.477 N/A GLN 66.A NE2 MET 323.A O no hydrogen 3.494 N/A LEU 71.A N ALA 62.A O no hydrogen 2.945 N/A GLN 72.A N GLN 72.A OE1 no hydrogen 2.596 N/A GLN 73.A NE2 PRO 335.A O no hydrogen 2.524 N/A ILE 75.A N ILE 60.A O no hydrogen 3.221 N/A CYS 77.A N ASN 58.A O no hydrogen 2.787 N/A CYS 77.A SG ILE 75.A O no hydrogen 3.721 N/A VAL 81.A N LYS 57.A O no hydrogen 3.334 N/A THR 82.A N GLY 96.A O no hydrogen 2.773 N/A LEU 84.A N ARG 40.A O no hydrogen 3.148 N/A THR 85.A N LEU 94.A O no hydrogen 2.851 N/A SER 87.A N TYR 92.A O no hydrogen 3.174 N/A SER 87.A OG ASN 89.A OD1 no hydrogen 2.831 N/A SER 87.A OG TYR 92.A O no hydrogen 3.388 N/A GLY 90.A N SER 87.A O no hydrogen 2.892 N/A LEU 91.A N SER 87.A OG no hydrogen 3.085 N/A LEU 91.A N ASN 89.A OD1 no hydrogen 2.717 N/A TYR 92.A N SER 87.A OG no hydrogen 3.139 N/A VAL 93.A N TRP 104.A O no hydrogen 3.302 N/A LEU 94.A N THR 85.A O no hydrogen 2.838 N/A ALA 95.A N HIS 102.A O no hydrogen 3.131 N/A GLY 96.A N CYS 83.A O no hydrogen 2.720 N/A VAL 97.A N SER 100.A O no hydrogen 2.806 N/A ALA 98.A N PRO 80.A O no hydrogen 3.311 N/A GLU 99.A N GLU 99.A OE1 no hydrogen 2.720 N/A SER 100.A N VAL 97.A O no hydrogen 2.892 N/A SER 100.A OG VAL 97.A O no hydrogen 2.794 N/A ILE 101.A N LEU 115.A O no hydrogen 2.659 N/A HIS 102.A N ALA 95.A O no hydrogen 2.931 N/A LEU 103.A N VAL 113.A O no hydrogen 3.292 N/A TRP 104.A N VAL 93.A O no hydrogen 3.008 N/A TRP 104.A NE1 ASN 338.A O no hydrogen 2.981 N/A GLU 105.A N ASN 110.A O no hydrogen 2.955 N/A VAL 106.A N LEU 91.A O no hydrogen 2.911 N/A THR 108.A OG1 GLU 105.A OE1 no hydrogen 2.730 N/A THR 108.A OG1 ASN 110.A OD1 no hydrogen 2.269 N/A GLY 109.A N GLU 105.A O no hydrogen 2.424 N/A LEU 112.A N LEU 103.A O no hydrogen 2.964 N/A LEU 115.A N ILE 101.A O no hydrogen 2.849 N/A HIS 118.A ND1 ASP 140.A OD1 no hydrogen 3.081 N/A HIS 118.A ND1 ASP 140.A OD2 no hydrogen 2.388 N/A HIS 118.A NE2 SER 136.A OG no hydrogen 2.928 N/A VAL 122.A N ALA 98.A O no hydrogen 3.130 N/A SER 123.A N GLY 137.A O no hydrogen 2.625 N/A SER 123.A OG ILE 173.A O no hydrogen 3.228 N/A CYS 124.A N GLY 137.A O no hydrogen 2.984 N/A CYS 124.A SG GLY 137.A O no hydrogen 3.845 N/A GLN 126.A N ILE 135.A O no hydrogen 3.086 N/A THR 128.A N HIS 133.A O no hydrogen 3.010 N/A THR 128.A OG1 HIS 133.A O no hydrogen 3.177 N/A SER 131.A N THR 128.A O no hydrogen 3.307 N/A SER 132.A OG ASP 130.A OD2 no hydrogen 3.088 N/A SER 132.A OG HIS 133.A ND1 no hydrogen 2.993 N/A HIS 133.A N THR 128.A OG1 no hydrogen 3.311 N/A HIS 133.A ND1 SER 132.A OG no hydrogen 2.993 N/A PHE 134.A N TRP 146.A O no hydrogen 3.282 N/A ILE 135.A N GLN 126.A O no hydrogen 2.819 N/A SER 136.A N LEU 144.A O no hydrogen 2.958 N/A SER 136.A OG HIS 118.A NE2 no hydrogen 2.928 N/A GLY 137.A N CYS 124.A O no hydrogen 3.032 N/A GLY 138.A N LEU 142.A O no hydrogen 3.452 N/A LYS 139.A N ASP 121.A O no hydrogen 2.682 N/A CYS 141.A N GLY 138.A O no hydrogen 3.182 N/A CYS 141.A SG LYS 139.A O no hydrogen 3.723 N/A LEU 142.A N ASP 140.A OD1 no hydrogen 3.092 N/A VAL 143.A N TRP 166.A O no hydrogen 3.006 N/A LEU 144.A N SER 136.A O no hydrogen 2.930 N/A VAL 145.A N HIS 164.A O no hydrogen 3.210 N/A TRP 146.A N PHE 134.A O no hydrogen 2.971 N/A TRP 146.A NE1 SER 136.A OG no hydrogen 3.191 N/A LEU 148.A N SER 132.A O no hydrogen 3.221 N/A CYS 149.A SG GLN 153.A OE1 no hydrogen 3.432 N/A VAL 151.A N SER 147.A O no hydrogen 2.917 N/A LEU 152.A N LEU 148.A O no hydrogen 3.044 N/A GLN 153.A N CYS 149.A O no hydrogen 3.293 N/A ALA 154.A N VAL 151.A O no hydrogen 3.460 N/A SER 157.A N ASP 155.A OD2 no hydrogen 3.088 N/A SER 157.A OG ASP 155.A OD2 no hydrogen 2.055 N/A ARG 158.A NE ASP 155.A OD2 no hydrogen 3.287 N/A ARG 163.A N VAL 145.A O no hydrogen 2.782 N/A ARG 163.A NH1 VAL 201.A O no hydrogen 2.895 N/A ARG 163.A NH2 SER 202.A O no hydrogen 3.340 N/A HIS 164.A N VAL 145.A O no hydrogen 3.275 N/A HIS 164.A NE2 SER 202.A O no hydrogen 3.234 N/A TRP 166.A N VAL 143.A O no hydrogen 2.890 N/A HIS 169.A NE2 THR 189.A OG1 no hydrogen 3.145 N/A ALA 170.A N ASP 193.A OD2 no hydrogen 3.448 N/A ILE 173.A N GLY 138.A O no hydrogen 3.508 N/A THR 174.A N SER 190.A O no hydrogen 3.055 N/A THR 174.A OG1 SER 190.A OG no hydrogen 2.656 N/A THR 174.A OG1 ILE 216.A O no hydrogen 2.897 N/A ASP 175.A N SER 190.A OG no hydrogen 3.201 N/A HIS 177.A N ALA 188.A O no hydrogen 2.646 N/A GLY 179.A N ARG 186.A O no hydrogen 2.973 N/A LEU 184.A N GLY 181.A O no hydrogen 3.479 N/A ALA 185.A N GLY 182.A O no hydrogen 2.885 N/A VAL 187.A N TRP 199.A O no hydrogen 2.962 N/A ALA 188.A N HIS 177.A O no hydrogen 2.768 N/A THR 189.A N LYS 197.A O no hydrogen 2.867 N/A THR 189.A OG1 HIS 169.A NE2 no hydrogen 3.145 N/A SER 190.A N ASP 175.A O no hydrogen 2.863 N/A SER 190.A OG THR 174.A OG1 no hydrogen 2.656 N/A SER 190.A OG ASP 175.A O no hydrogen 3.058 N/A SER 191.A OG LEU 171.A O no hydrogen 2.762 N/A SER 191.A OG PRO 172.A O no hydrogen 2.809 N/A SER 191.A OG ASP 193.A OD1 no hydrogen 2.618 N/A LEU 192.A N PRO 172.A O no hydrogen 3.021 N/A THR 195.A N ASP 193.A O no hydrogen 2.463 N/A THR 195.A OG1 ASP 193.A O no hydrogen 3.229 N/A THR 195.A OG1 ASP 193.A OD1 no hydrogen 3.325 N/A THR 195.A OG1 ASP 193.A OD2 no hydrogen 3.160 N/A VAL 196.A N VAL 210.A O no hydrogen 3.081 N/A LYS 197.A N THR 189.A O no hydrogen 2.941 N/A LYS 197.A NZ SER 209.A OG no hydrogen 3.102 N/A LEU 198.A N LEU 208.A O no hydrogen 3.051 N/A TRP 199.A N VAL 187.A O no hydrogen 2.676 N/A TRP 199.A NE1 THR 189.A OG1 no hydrogen 3.068 N/A GLU 200.A N GLU 205.A O no hydrogen 3.187 N/A VAL 201.A N ALA 185.A O no hydrogen 3.282 N/A SER 203.A OG GLU 200.A OE1 no hydrogen 2.873 N/A GLY 204.A N GLU 200.A O no hydrogen 2.849 N/A LEU 207.A N LEU 198.A O no hydrogen 2.942 N/A SER 209.A N ARG 249.A O no hydrogen 3.282 N/A VAL 210.A N VAL 196.A O no hydrogen 3.015 N/A LEU 211.A N ARG 251.A O no hydrogen 2.889 N/A PHE 212.A N GLN 194.A O no hydrogen 2.628 N/A SER 215.A OG LEU 192.A O no hydrogen 2.781 N/A MET 217.A N GLY 231.A O no hydrogen 2.821 N/A THR 220.A N PHE 229.A O no hydrogen 3.099 N/A GLU 225.A N ASP 222.A O no hydrogen 2.748 N/A HIS 227.A ND1 ASP 241.A OD1 no hydrogen 2.700 N/A MET 228.A N VAL 240.A O no hydrogen 2.761 N/A PHE 229.A N THR 220.A O no hydrogen 2.995 N/A CYS 230.A N PHE 238.A O no hydrogen 2.771 N/A GLY 231.A N ALA 218.A O no hydrogen 3.088 N/A GLY 232.A N SER 236.A O no hydrogen 2.926 N/A SER 236.A OG GLU 234.A OE2 no hydrogen 3.344 N/A ILE 237.A N PHE 263.A O no hydrogen 3.408 N/A PHE 238.A N CYS 230.A O no hydrogen 2.757 N/A GLN 239.A N LYS 261.A O no hydrogen 3.116 N/A VAL 240.A N MET 228.A O no hydrogen 2.681 N/A LEU 242.A N HIS 226.A O no hydrogen 2.840 N/A PHE 243.A N HIS 226.A O no hydrogen 3.421 N/A TRP 245.A N LEU 242.A O no hydrogen 3.276 N/A TRP 245.A NE1 GLN 248.A O no hydrogen 2.785 N/A ARG 251.A N SER 209.A O no hydrogen 3.118 N/A PHE 253.A N LEU 211.A O no hydrogen 3.093 N/A HIS 254.A N ASP 258.A OD2 no hydrogen 3.055 N/A ASP 258.A N HIS 254.A O no hydrogen 2.940 N/A ALA 259.A N GLU 256.A O no hydrogen 3.262 N/A LYS 261.A N ASP 258.A O no hydrogen 3.056 N/A LYS 261.A NZ GLN 239.A O no hydrogen 3.239 N/A VAL 262.A N ALA 259.A O no hydrogen 3.457 N/A PHE 263.A N ILE 237.A O no hydrogen 2.834 N/A HIS 266.A NE2 SER 284.A OG no hydrogen 3.146 N/A ARG 267.A N ASP 288.A OD2 no hydrogen 3.207 N/A GLN 269.A N ASN 268.A OD1 no hydrogen 3.089 N/A VAL 270.A N GLY 232.A O no hydrogen 3.121 N/A THR 271.A N GLY 285.A O no hydrogen 2.972 N/A THR 271.A OG1 VAL 311.A O no hydrogen 3.341 N/A CYS 272.A N GLY 285.A O no hydrogen 3.292 N/A CYS 272.A SG THR 271.A OG1 no hydrogen 3.759 N/A CYS 272.A SG VAL 311.A O no hydrogen 4.015 N/A SER 274.A N LEU 283.A O no hydrogen 2.953 N/A SER 276.A N VAL 281.A O no hydrogen 3.095 N/A SER 276.A OG ASP 278.A OD1 no hydrogen 2.831 N/A SER 276.A OG VAL 281.A O no hydrogen 3.297 N/A THR 277.A N GLU 4.A OE1 no hydrogen 3.484 N/A GLY 279.A N SER 276.A O no hydrogen 3.126 N/A SER 280.A N ASP 278.A OD1 no hydrogen 2.850 N/A SER 280.A OG ASP 278.A OD1 no hydrogen 2.625 N/A SER 280.A OG ASP 278.A OD2 no hydrogen 3.181 N/A VAL 281.A N SER 276.A OG no hydrogen 3.142 N/A LEU 282.A N TRP 294.A O no hydrogen 3.120 N/A LEU 283.A N SER 274.A O no hydrogen 2.797 N/A SER 284.A N ARG 292.A O no hydrogen 3.097 N/A SER 284.A OG HIS 266.A NE2 no hydrogen 3.146 N/A SER 284.A OG ARG 292.A O no hydrogen 3.535 N/A GLY 285.A N CYS 272.A O no hydrogen 3.112 N/A SER 286.A N THR 290.A O no hydrogen 3.478 N/A SER 286.A OG ASN 268.A O no hydrogen 2.729 N/A SER 286.A OG GLN 269.A O no hydrogen 2.897 N/A HIS 287.A N GLN 269.A O no hydrogen 3.270 N/A THR 290.A OG1 VAL 305.A O no hydrogen 3.087 N/A VAL 291.A N VAL 305.A O no hydrogen 2.820 N/A ARG 292.A N SER 284.A O no hydrogen 3.104 N/A LEU 293.A N ARG 303.A O no hydrogen 2.978 N/A TRP 294.A N LEU 282.A O no hydrogen 2.819 N/A TRP 294.A NE1 SER 284.A OG no hydrogen 2.687 N/A ASP 295.A N GLN 300.A O no hydrogen 2.703 N/A VAL 296.A N SER 280.A O no hydrogen 2.796 N/A SER 298.A N ASP 295.A OD2 no hydrogen 3.254 N/A SER 298.A OG ASP 295.A OD2 no hydrogen 2.502 N/A LYS 299.A N ASP 295.A O no hydrogen 2.573 N/A LYS 299.A NZ VAL 296.A O no hydrogen 2.685 N/A CYS 301.A SG LEU 293.A O no hydrogen 3.523 N/A CYS 301.A SG ARG 303.A O no hydrogen 3.155 N/A CYS 301.A SG THR 304.A OG1 no hydrogen 3.510 N/A ILE 302.A N LEU 293.A O no hydrogen 2.588 N/A ARG 303.A N LEU 293.A O no hydrogen 3.485 N/A VAL 305.A N VAL 291.A O no hydrogen 2.799 N/A LEU 307.A N GLU 289.A O no hydrogen 2.768 N/A GLY 309.A N ASP 10.A OD2 no hydrogen 3.302 N/A VAL 311.A N SER 286.A O no hydrogen 3.317 N/A THR 312.A N THR 9.A O no hydrogen 3.085 N/A THR 312.A OG1 THR 9.A O no hydrogen 3.146 N/A THR 312.A OG1 THR 9.A OG1 no hydrogen 2.894 N/A THR 312.A OG1 ALA 37.A O no hydrogen 3.511 N/A ASN 313.A ND2 GLY 38.A O no hydrogen 3.251 N/A ALA 315.A N VAL 7.A O no hydrogen 3.168 N/A ILE 316.A N SER 274.A OG no hydrogen 2.834 N/A LEU 317.A N VAL 5.A O no hydrogen 2.935 N/A ALA 319.A N MET 3.A O no hydrogen 2.876 N/A SER 322.A OG GLY 47.A O no hydrogen 2.494 N/A MET 323.A N PRO 320.A O no hydrogen 3.249 N/A SER 325.A N VAL 321.A O no hydrogen 3.197 N/A SER 325.A OG ASP 327.A OD1 no hydrogen 2.342 N/A ARG 329.A NH1 GLU 64.A OE1 no hydrogen 2.505 N/A ASN 338.A N GLY 109.A O no hydrogen 3.171 N/A ARG 348.A NE SER 331.A O no hydrogen 3.640 N/A GLN 353.A N GLY 350.A O no hydrogen 3.336 N/A GLN 354.A N LEU 351.A O no hydrogen 3.194 N/A SER 356.A N GLN 353.A O no hydrogen 3.192 N/A SER 356.A OG GLN 353.A O no hydrogen 2.764 N/A GLU 357.A N GLU 357.A OE1 no hydrogen 2.743 N/A SER 359.A N ASP 362.A OD2 no hydrogen 3.473 N/A ARG 363.A N SER 359.A O no hydrogen 2.961 N/A THR 364.A N TYR 360.A O no hydrogen 3.141 N/A THR 364.A OG1 TYR 360.A O no hydrogen 3.244 N/A THR 364.A OG1 LEU 361.A O no hydrogen 2.844 N/A GLU 365.A N LEU 361.A O no hydrogen 2.971 N/A GLN 366.A N ASP 362.A O no hydrogen 3.253 N/A LEU 367.A N ARG 363.A O no hydrogen 3.068 N/A GLN 368.A N THR 364.A O no hydrogen 2.693 N/A ALA 369.A N GLU 365.A O no hydrogen 2.939 N/A VAL 370.A N GLN 366.A O no hydrogen 3.220 N/A VAL 370.A N LEU 367.A O no hydrogen 3.214 N/A LEU 371.A N LEU 367.A O no hydrogen 3.333 N/A CYS 372.A N GLN 368.A O no hydrogen 3.274 N/A CYS 372.A SG GLN 368.A O no hydrogen 3.467 N/A SER 373.A N ALA 369.A O no hydrogen 3.003 N/A THR 374.A N VAL 370.A O no hydrogen 2.818 N/A THR 374.A OG1 VAL 370.A O no hydrogen 2.653 N/A THR 374.A OG1 LEU 371.A O no hydrogen 3.081 N/A MET 375.A N LEU 371.A O no hydrogen 2.859 N/A GLU 376.A N CYS 372.A O no hydrogen 3.079 N/A LYS 377.A N SER 373.A O no hydrogen 3.233 N/A SER 378.A N THR 374.A O no hydrogen 2.857 N/A VAL 379.A N MET 375.A O no hydrogen 2.610 N/A LEU 380.A N GLU 376.A O no hydrogen 2.850 N/A GLY 381.A N LYS 377.A O no hydrogen 3.206 N/A