Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8g5n_B.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): CYS 10.A SG ILE 9.A O no hydrogen 2.851 N/A ARG 12.A N GLU 8.A O no hydrogen 3.498 N/A ARG 13.A NH1 GLU 356.A OE1 no hydrogen 2.870 N/A HIS 14.A NE2 GLU 356.A OE1 no hydrogen 2.390 N/A PHE 15.A N ARG 12.A O no hydrogen 3.210 N/A LEU 16.A N GLN 11.A O no hydrogen 3.121 N/A SER 17.A OG GLN 11.A OE1 no hydrogen 3.002 N/A GLY 18.A N GLY 35.A O no hydrogen 2.828 N/A LYS 20.A NZ GLN 22.A OE1 no hydrogen 2.292 N/A SER 27.A N SER 24.A OG no hydrogen 3.347 N/A LEU 28.A N SER 24.A O no hydrogen 3.180 N/A LEU 29.A N ARG 25.A O no hydrogen 2.915 N/A SER 30.A N ASP 26.A O no hydrogen 2.882 N/A GLY 31.A N SER 27.A O no hydrogen 3.006 N/A GLY 31.A N LEU 28.A O no hydrogen 3.096 N/A CYS 32.A N SER 27.A O no hydrogen 3.256 N/A CYS 32.A SG SER 30.A OG no hydrogen 2.998 N/A CYS 32.A SG SER 158.A OG no hydrogen 3.214 N/A CYS 32.A SG ILE 159.A O no hydrogen 3.814 N/A HIS 33.A NE2 GLY 18.A O no hydrogen 3.277 N/A LEU 39.A N PHE 15.A O no hydrogen 3.085 N/A VAL 41.A N GLY 37.A O no hydrogen 2.864 N/A GLU 42.A N PRO 38.A O no hydrogen 2.907 N/A LEU 43.A N LEU 39.A O no hydrogen 2.876 N/A ARG 44.A N GLY 40.A O no hydrogen 2.907 N/A LYS 45.A N VAL 41.A O no hydrogen 2.882 N/A LYS 45.A NZ GLU 42.A OE1 no hydrogen 2.846 N/A ASN 46.A N GLU 42.A O no hydrogen 2.879 N/A LEU 47.A N LEU 43.A O no hydrogen 2.912 N/A ALA 48.A N ARG 44.A O no hydrogen 2.895 N/A ALA 49.A N LYS 45.A O no hydrogen 2.866 N/A GLU 50.A N ASN 46.A O no hydrogen 2.908 N/A TRP 51.A N LEU 47.A O no hydrogen 2.916 N/A TRP 52.A N ALA 48.A O no hydrogen 2.877 N/A THR 53.A N ALA 49.A O no hydrogen 2.881 N/A THR 53.A OG1 ALA 49.A O no hydrogen 3.054 N/A THR 53.A OG1 GLU 50.A O no hydrogen 2.544 N/A SER 54.A N GLU 50.A O no hydrogen 2.924 N/A VAL 55.A N TRP 52.A O no hydrogen 3.372 N/A VAL 56.A N TRP 52.A O no hydrogen 2.922 N/A VAL 57.A N TRP 52.A O no hydrogen 3.239 N/A ARG 59.A NE PHE 58.A O no hydrogen 2.689 N/A ARG 59.A NH2 HIS 186.A NE2 no hydrogen 3.133 N/A PHE 63.A N GLY 135.A O no hydrogen 3.251 N/A LYS 71.A N LYS 108.A O no hydrogen 3.184 N/A SER 80.A N ASP 79.A OD1 no hydrogen 2.531 N/A LEU 84.A N SER 80.A O no hydrogen 3.181 N/A LEU 103.A N ASN 101.A O no hydrogen 3.124 N/A THR 105.A OG1 LYS 104.A O no hydrogen 2.434 N/A SER 106.A N LEU 103.A O no hydrogen 3.128 N/A SER 106.A OG LEU 103.A O no hydrogen 2.991 N/A LYS 108.A NZ GLU 111.A OE2 no hydrogen 3.202 N/A ARG 110.A NE VAL 141.A O no hydrogen 2.618 N/A ARG 110.A NH1 ALA 67.A O no hydrogen 3.409 N/A ARG 110.A NH2 VAL 141.A O no hydrogen 2.546 N/A GLU 111.A N GLU 111.A OE1 no hydrogen 2.549 N/A HIS 115.A N ASN 112.A OD1 no hydrogen 2.952 N/A GLY 116.A N LEU 113.A O no hydrogen 3.211 N/A LEU 118.A N LEU 114.A O no hydrogen 2.899 N/A GLU 119.A N HIS 115.A O no hydrogen 2.900 N/A HIS 120.A N GLY 116.A O no hydrogen 2.891 N/A TYR 121.A N LEU 118.A O no hydrogen 3.340 N/A TYR 121.A OH LEU 250.A O no hydrogen 3.224 N/A CYS 124.A N HIS 120.A O no hydrogen 2.887 N/A CYS 124.A SG HIS 120.A O no hydrogen 3.389 N/A LEU 127.A N CYS 124.A O no hydrogen 3.276 N/A ASN 129.A N ASP 126.A O no hydrogen 3.338 N/A ASN 129.A ND2 ASN 129.A O no hydrogen 2.950 N/A LYS 130.A N LEU 125.A O no hydrogen 3.075 N/A ARG 131.A N VAL 128.A O no hydrogen 2.983 N/A LEU 132.A N ARG 253.A O no hydrogen 3.043 N/A TYR 134.A N PHE 170.A O no hydrogen 2.990 N/A GLY 135.A N GLN 61.A O no hydrogen 3.085 N/A LEU 136.A N VAL 168.A O no hydrogen 2.911 N/A ALA 137.A N PHE 63.A O no hydrogen 3.342 N/A GLN 138.A N SER 166.A O no hydrogen 2.920 N/A GLY 140.A N GLU 164.A O no hydrogen 2.926 N/A CYS 142.A N LYS 162.A O no hydrogen 2.873 N/A CYS 142.A SG GLU 164.A OE1 no hydrogen 3.215 N/A CYS 142.A SG GLU 164.A OE2 no hydrogen 3.728 N/A PHE 143.A N ARG 110.A O no hydrogen 3.442 N/A HIS 144.A N GLY 160.A O no hydrogen 2.875 N/A HIS 144.A NE2 GLU 111.A O no hydrogen 2.461 N/A VAL 146.A N SER 158.A O no hydrogen 2.869 N/A THR 149.A OG1 ASP 148.A O no hydrogen 2.632 N/A LYS 150.A NZ GLN 151.A OE1 no hydrogen 2.930 N/A LYS 157.A NZ SER 80.A OG no hydrogen 2.847 N/A GLY 160.A N HIS 144.A O no hydrogen 2.938 N/A GLU 161.A N GLY 31.A O no hydrogen 2.944 N/A GLU 161.A N GLU 161.A OE1 no hydrogen 2.872 N/A LYS 162.A N CYS 142.A O no hydrogen 2.922 N/A LYS 162.A NZ SER 30.A O no hydrogen 3.082 N/A LYS 162.A NZ HIS 144.A ND1 no hydrogen 3.368 N/A THR 163.A N ASP 271.A OD1 no hydrogen 3.440 N/A GLU 164.A N GLY 140.A O no hydrogen 2.892 N/A ALA 165.A N GLY 268.A O no hydrogen 2.871 N/A SER 166.A N GLN 138.A O no hydrogen 2.877 N/A LEU 167.A N VAL 266.A O no hydrogen 2.896 N/A VAL 168.A N LEU 136.A O no hydrogen 2.896 N/A TRP 169.A N LEU 264.A O no hydrogen 2.875 N/A PHE 170.A N TYR 134.A O no hydrogen 2.845 N/A THR 171.A N CYS 262.A O no hydrogen 2.926 N/A THR 175.A OG1 THR 175.A O no hydrogen 2.437 N/A SER 176.A N PRO 173.A O no hydrogen 3.161 N/A SER 176.A OG PRO 172.A O no hydrogen 2.890 N/A SER 176.A OG PRO 173.A O no hydrogen 3.353 N/A GLN 178.A N ASN 177.A OD1 no hydrogen 2.849 N/A TRP 179.A N THR 175.A O no hydrogen 2.922 N/A LEU 180.A N SER 176.A O no hydrogen 2.872 N/A ASP 181.A N ASN 177.A O no hydrogen 2.925 N/A PHE 182.A N GLN 178.A O no hydrogen 2.883 N/A TRP 183.A N TRP 179.A O no hydrogen 2.875 N/A LEU 184.A N LEU 180.A O no hydrogen 2.890 N/A ARG 185.A N ASP 181.A O no hydrogen 2.921 N/A HIS 186.A N PHE 182.A O no hydrogen 2.876 N/A ARG 187.A N TRP 183.A O no hydrogen 2.895 N/A LEU 188.A N LEU 184.A O no hydrogen 2.905 N/A GLN 189.A N ARG 185.A O no hydrogen 2.890 N/A TRP 190.A N HIS 186.A O no hydrogen 2.898 N/A TRP 191.A N ARG 187.A O no hydrogen 2.896 N/A ARG 192.A N LEU 188.A O no hydrogen 2.871 N/A LYS 193.A N GLN 189.A O no hydrogen 2.569 N/A ALA 195.A N ARG 192.A O no hydrogen 3.234 N/A MET 196.A N ASP 280.A OD2 no hydrogen 2.760 N/A SER 197.A N ASP 280.A OD2 no hydrogen 3.312 N/A ASN 200.A N SER 197.A O no hydrogen 3.133 N/A PHE 201.A N PRO 198.A O no hydrogen 3.182 N/A SER 202.A N TYR 218.A O no hydrogen 2.907 N/A SER 202.A OG TYR 218.A O no hydrogen 3.502 N/A SER 204.A N LYS 216.A O no hydrogen 2.911 N/A SER 204.A OG LYS 216.A O no hydrogen 3.447 N/A CYS 206.A N GLY 214.A O no hydrogen 2.895 N/A CYS 206.A SG GLY 214.A O no hydrogen 3.321 N/A ASP 208.A N ARG 212.A O no hydrogen 2.564 N/A GLU 209.A N ASP 208.A OD1 no hydrogen 2.579 N/A ARG 212.A NE ASP 208.A OD2 no hydrogen 3.176 N/A ARG 212.A NH1 LEU 234.A O no hydrogen 2.436 N/A ARG 212.A NH2 ASP 208.A OD2 no hydrogen 3.480 N/A LYS 213.A NZ ASP 205.A OD1 no hydrogen 3.481 N/A LYS 213.A NZ ASN 215.A OD1 no hydrogen 2.906 N/A GLY 214.A N CYS 206.A O no hydrogen 2.917 N/A ASN 215.A N LEU 231.A O no hydrogen 2.881 N/A ASN 215.A ND2 SER 204.A O no hydrogen 3.457 N/A LYS 216.A N SER 204.A O no hydrogen 2.889 N/A LEU 217.A N GLU 229.A O no hydrogen 2.722 N/A TYR 218.A N SER 202.A O no hydrogen 2.897 N/A TYR 219.A N GLU 226.A O no hydrogen 2.917 N/A ASN 220.A N ASN 200.A O no hydrogen 3.194 N/A ASN 220.A ND2 ASN 220.A O no hydrogen 2.889 N/A PHE 221.A N TYR 219.A O no hydrogen 3.031 N/A TRP 223.A NE1 GLU 226.A OE2 no hydrogen 2.590 N/A GLU 226.A N TYR 219.A O no hydrogen 2.906 N/A ILE 228.A N LEU 217.A O no hydrogen 2.914 N/A GLU 229.A N LEU 217.A O no hydrogen 3.384 N/A THR 230.A N ASN 267.A O no hydrogen 2.901 N/A THR 230.A OG1 ASN 267.A O no hydrogen 3.443 N/A LEU 231.A N ASN 215.A O no hydrogen 2.789 N/A TRP 232.A N SER 265.A O no hydrogen 2.912 N/A LEU 234.A N VAL 263.A O no hydrogen 2.758 N/A GLY 235.A N ASN 233.A OD1 no hydrogen 3.209 N/A GLU 238.A N GLU 238.A OE1 no hydrogen 2.605 N/A LEU 240.A N ASP 236.A O no hydrogen 3.197 N/A HIS 241.A N HIS 237.A O no hydrogen 2.907 N/A MET 242.A N GLU 238.A O no hydrogen 2.900 N/A TYR 243.A N LEU 240.A O no hydrogen 3.090 N/A SER 248.A N ASN 246.A OD1 no hydrogen 3.150 N/A LYS 249.A NZ ASN 246.A O no hydrogen 2.845 N/A LEU 250.A N VAL 247.A O no hydrogen 3.409 N/A ARG 253.A N LYS 130.A O no hydrogen 2.943 N/A ASP 254.A N LYS 257.A O no hydrogen 2.899 N/A LYS 257.A N ASP 254.A O no hydrogen 2.905 N/A LYS 257.A NZ ASP 254.A O no hydrogen 3.186 N/A LYS 257.A NZ ASP 254.A OD2 no hydrogen 2.914 N/A VAL 259.A N GLY 252.A O no hydrogen 2.900 N/A CYS 262.A N THR 171.A O no hydrogen 2.894 N/A CYS 262.A SG SER 176.A OG no hydrogen 3.299 N/A CYS 262.A SG ASN 233.A OD1 no hydrogen 3.210 N/A LEU 264.A N TRP 169.A O no hydrogen 2.905 N/A SER 265.A N TRP 232.A O no hydrogen 2.902 N/A VAL 266.A N LEU 167.A O no hydrogen 2.942 N/A ASN 267.A N THR 230.A O no hydrogen 2.915 N/A GLY 268.A N ALA 165.A O no hydrogen 2.906 N/A ASP 269.A N ILE 228.A O no hydrogen 2.877 N/A LEU 270.A N THR 163.A O no hydrogen 2.750 N/A ASP 271.A N THR 163.A O no hydrogen 3.264 N/A ARG 272.A N ASP 269.A OD1 no hydrogen 2.672 N/A ARG 272.A NE LEU 29.A O no hydrogen 3.242 N/A ARG 272.A NH2 LEU 29.A O no hydrogen 2.803 N/A GLY 273.A N ASP 269.A O no hydrogen 2.836 N/A MET 274.A N LEU 270.A O no hydrogen 3.098 N/A ALA 276.A N ARG 272.A O no hydrogen 3.033 N/A TYR 277.A N GLY 273.A O no hydrogen 2.883 N/A LEU 278.A N MET 274.A O no hydrogen 2.913 N/A TYR 279.A N LEU 275.A O no hydrogen 2.899 N/A ASP 280.A N ALA 276.A O no hydrogen 2.863 N/A SER 281.A N TYR 277.A O no hydrogen 2.903 N/A SER 281.A OG TYR 277.A O no hydrogen 2.876 N/A SER 281.A OG LEU 278.A O no hydrogen 2.597 N/A PHE 282.A N LEU 278.A O no hydrogen 3.241 N/A THR 284.A OG1 GLN 283.A OE1 no hydrogen 2.139 N/A ARG 291.A NE ASP 355.A OD2 no hydrogen 2.931 N/A ARG 291.A NH2 ASP 355.A OD2 no hydrogen 2.812 N/A ARG 291.A NH2 ARG 380.A O no hydrogen 2.495 N/A CYS 299.A N HIS 297.A ND1 no hydrogen 3.261 N/A CYS 299.A SG GLU 50.A OE1 no hydrogen 3.142 N/A CYS 299.A SG GLU 50.A OE2 no hydrogen 3.196 N/A LEU 300.A N HIS 297.A O no hydrogen 3.255 N/A LYS 304.A N SER 334.A OG no hydrogen 3.252 N/A LYS 304.A NZ PRO 298.A O no hydrogen 2.906 N/A LYS 304.A NZ ALA 301.A O no hydrogen 3.411 N/A ALA 306.A N PHE 361.A O no hydrogen 3.025 N/A GLY 310.A N VAL 365.A O no hydrogen 3.367 N/A THR 314.A OG1 THR 314.A O no hydrogen 2.372 N/A LEU 317.A N THR 314.A O no hydrogen 3.079 N/A ARG 318.A N LEU 315.A O no hydrogen 2.919 N/A GLN 319.A N GLN 319.A OE1 no hydrogen 2.529 N/A CYS 321.A N ARG 318.A O no hydrogen 2.925 N/A CYS 321.A SG ARG 318.A O no hydrogen 3.044 N/A GLY 323.A N ASN 326.A OD1 no hydrogen 2.558 N/A PHE 325.A N CYS 321.A O no hydrogen 2.706 N/A GLU 327.A N GLY 323.A O no hydrogen 2.402 N/A LEU 328.A N LEU 324.A O no hydrogen 2.771 N/A LEU 329.A N PHE 325.A O no hydrogen 2.968 N/A GLU 330.A N ASN 326.A O no hydrogen 3.308 N/A GLU 330.A N GLU 327.A O no hydrogen 2.930 N/A GLY 332.A N LEU 329.A O no hydrogen 3.412 N/A SER 334.A OG PRO 302.A O no hydrogen 3.281 N/A TRP 336.A N VAL 305.A O no hydrogen 2.894 N/A GLY 338.A N TRP 336.A O no hydrogen 2.598 N/A TYR 339.A N ASP 308.A OD1 no hydrogen 3.250 N/A THR 342.A OG1 THR 342.A O no hydrogen 2.503 N/A SER 345.A N MET 343.A O no hydrogen 2.684 N/A GLN 349.A N SER 346.A OG no hydrogen 3.343 N/A LEU 350.A N SER 346.A O no hydrogen 3.044 N/A TYR 351.A N LEU 347.A O no hydrogen 2.905 N/A SER 352.A N GLU 348.A O no hydrogen 2.895 N/A SER 352.A OG GLU 348.A O no hydrogen 3.276 N/A SER 352.A OG GLN 349.A O no hydrogen 2.563 N/A LYS 353.A N GLN 349.A O no hydrogen 2.904 N/A TYR 354.A N LEU 350.A O no hydrogen 2.923 N/A TYR 354.A OH ASP 308.A OD1 no hydrogen 3.209 N/A TYR 354.A OH ASP 308.A OD2 no hydrogen 2.563 N/A ASP 355.A N TYR 351.A O no hydrogen 2.856 N/A GLU 356.A N SER 352.A O no hydrogen 2.929 N/A MET 357.A N LYS 353.A O no hydrogen 3.058 N/A SER 358.A N ASP 355.A O no hydrogen 2.952 N/A ILE 359.A N TYR 354.A O no hydrogen 3.273 N/A PHE 361.A N LYS 304.A O no hydrogen 2.914 N/A THR 362.A N ARG 378.A O no hydrogen 2.900 N/A VAL 363.A N ALA 306.A O no hydrogen 2.742 N/A LEU 364.A N HIS 376.A O no hydrogen 2.901 N/A VAL 365.A N ASP 308.A O no hydrogen 3.046 N/A THR 366.A N THR 369.A OG1 no hydrogen 2.989 N/A THR 366.A OG1 THR 368.A OG1 no hydrogen 3.319 N/A GLU 367.A N GLU 367.A OE1 no hydrogen 2.646 N/A THR 368.A OG1 THR 366.A OG1 no hydrogen 3.319 N/A THR 368.A OG1 GLU 367.A OE2 no hydrogen 3.279 N/A THR 369.A N THR 366.A O no hydrogen 3.021 N/A THR 369.A OG1 THR 366.A O no hydrogen 2.675 N/A THR 369.A OG1 LEU 374.A O no hydrogen 3.349 N/A GLU 371.A N GLU 371.A OE1 no hydrogen 2.545 N/A ASN 372.A ND2 ASN 372.A O no hydrogen 2.322 N/A ILE 375.A N MET 387.A O no hydrogen 3.301 N/A HIS 376.A N LEU 364.A O no hydrogen 2.936 N/A LEU 377.A N GLU 386.A O no hydrogen 3.131 N/A ARG 378.A N THR 362.A O no hydrogen 2.900 N/A ARG 378.A NH1 ASP 355.A OD1 no hydrogen 3.230 N/A ARG 378.A NH2 ASP 355.A OD2 no hydrogen 3.258 N/A SER 379.A OG THR 382.A O no hydrogen 2.207 N/A SER 379.A OG MET 384.A O no hydrogen 3.468 N/A ARG 380.A N LEU 360.A O no hydrogen 2.830 N/A ARG 380.A NH1 LEU 296.A O no hydrogen 2.830 N/A ARG 380.A NH2 LEU 296.A O no hydrogen 2.431 N/A ARG 380.A NH2 ASP 381.A OD1 no hydrogen 3.548 N/A MET 384.A N THR 382.A O no hydrogen 2.723 N/A GLU 386.A N LEU 377.A O no hydrogen 2.721 N/A HIS 389.A ND1 SER 391.A OG no hydrogen 3.242 N/A SER 391.A N HIS 389.A ND1 no hydrogen 3.442 N/A SER 391.A OG HIS 389.A ND1 no hydrogen 3.242 N/A LYS 392.A N HIS 389.A O no hydrogen 3.365 N/A LEU 393.A N ILE 390.A O no hydrogen 2.928 N/A LYS 394.A NZ GLU 327.A O no hydrogen 2.590 N/A LYS 394.A NZ ASN 331.A OD1 no hydrogen 2.952 N/A LEU 397.A N LEU 393.A O no hydrogen 2.971 N/A ILE 398.A N LYS 394.A O no hydrogen 3.022 N/A LYS 399.A N ASP 395.A O no hydrogen 2.641 N/A TYR 400.A N PHE 396.A O no hydrogen 2.691 N/A ILE 401.A N LEU 397.A O no hydrogen 2.847 N/A SER 402.A N ILE 398.A O no hydrogen 2.698 N/A SER 402.A OG ILE 398.A O no hydrogen 3.107 N/A SER 403.A N LYS 399.A O no hydrogen 2.512 N/A ALA 404.A N TYR 400.A O no hydrogen 2.672 N/A LYS 405.A N ILE 401.A O no hydrogen 2.787 N/A LYS 405.A N SER 402.A O no hydrogen 2.937 N/A