Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8h6l_4C.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): GLU 6.A N GLU 2.A O no hydrogen 2.906 N/A PHE 7.A N VAL 3.A O no hydrogen 2.901 N/A GLU 8.A N LEU 4.A O no hydrogen 2.882 N/A ARG 9.A N ALA 5.A O no hydrogen 2.913 N/A ARG 10.A N GLU 6.A O no hydrogen 2.898 N/A LYS 11.A N PHE 7.A O no hydrogen 2.903 N/A ARG 12.A N GLU 8.A O no hydrogen 2.889 N/A ALA 13.A N ARG 9.A O no hydrogen 2.911 N/A ARG 14.A N ARG 10.A O no hydrogen 2.902 N/A GLN 15.A N LYS 11.A O no hydrogen 2.941 N/A GLN 15.A NE2 LYS 11.A O no hydrogen 2.540 N/A ILE 16.A N ALA 13.A O no hydrogen 3.470 N/A THR 20.A OG1 THR 20.A O no hydrogen 2.368 N/A SER 23.A OG ASP 21.A OD1 no hydrogen 3.019 N/A GLU 24.A N ASP 21.A OD1 no hydrogen 2.943 N/A VAL 25.A N ASP 21.A O no hydrogen 2.891 N/A LYS 26.A N ASP 22.A O no hydrogen 2.907 N/A ALA 27.A N SER 23.A O no hydrogen 2.893 N/A CYS 28.A N GLU 24.A O no hydrogen 2.898 N/A LEU 29.A N VAL 25.A O no hydrogen 2.938 N/A ARG 30.A N LYS 26.A O no hydrogen 2.909 N/A ALA 31.A N ALA 27.A O no hydrogen 2.885 N/A LEU 32.A N CYS 28.A O no hydrogen 2.931 N/A GLY 33.A N ARG 30.A O no hydrogen 2.978 N/A GLU 34.A N LEU 29.A O no hydrogen 2.909 N/A LEU 38.A N GLU 41.A OE1 no hydrogen 3.421 N/A GLY 42.A N GLU 45.A OE1 no hydrogen 2.495 N/A GLU 45.A N GLU 45.A OE1 no hydrogen 2.942 N/A ARG 46.A N GLY 42.A O no hydrogen 2.801 N/A ARG 46.A NH2 ASP 22.A OD1 no hydrogen 2.704 N/A ARG 47.A N PRO 43.A O no hydrogen 2.907 N/A ARG 47.A NE SER 19.A O no hydrogen 2.911 N/A ARG 47.A NH2 VAL 18.A O no hydrogen 3.302 N/A GLU 48.A N ALA 44.A O no hydrogen 2.939 N/A ARG 49.A N GLU 45.A O no hydrogen 2.852 N/A ARG 49.A NE GLU 41.A OE2 no hydrogen 2.825 N/A ARG 49.A NH1 PRO 35.A O no hydrogen 2.701 N/A ARG 49.A NH2 PRO 35.A O no hydrogen 3.291 N/A ARG 49.A NH2 ILE 36.A O no hydrogen 3.510 N/A ARG 49.A NH2 GLU 41.A OE1 no hydrogen 2.423 N/A LEU 50.A N ARG 46.A O no hydrogen 2.932 N/A ARG 51.A N ARG 47.A O no hydrogen 2.925 N/A ARG 51.A NH2 ILE 16.A O no hydrogen 2.915 N/A ASN 52.A N GLU 48.A O no hydrogen 2.909 N/A ILE 53.A N ARG 49.A O no hydrogen 2.903 N/A LEU 54.A N LEU 50.A O no hydrogen 2.878 N/A SER 55.A N ARG 51.A O no hydrogen 2.959 N/A SER 55.A N ASN 52.A O no hydrogen 3.203 N/A SER 55.A OG ARG 51.A O no hydrogen 3.535 N/A VAL 56.A N ASN 52.A O no hydrogen 2.669 N/A VAL 57.A N ASN 52.A O no hydrogen 3.094 N/A THR 65.A OG1 LEU 62.A O no hydrogen 3.036 N/A LYS 66.A NZ ALA 61.A O no hydrogen 3.430 N/A LYS 67.A NZ LYS 63.A O no hydrogen 3.314 N/A TRP 70.A N GLN 68.A O no hydrogen 2.632 N/A LEU 78.A N PRO 75.A O no hydrogen 3.240 N/A VAL 80.A N ASN 76.A O no hydrogen 2.964 N/A ALA 81.A N SER 77.A O no hydrogen 2.922 N/A ARG 82.A N LEU 78.A O no hydrogen 2.866 N/A LEU 83.A N LYS 79.A O no hydrogen 2.958 N/A TRP 84.A N VAL 80.A O no hydrogen 2.919 N/A ILE 85.A N ALA 81.A O no hydrogen 2.877 N/A ALA 86.A N ARG 82.A O no hydrogen 2.908 N/A ASN 87.A N LEU 83.A O no hydrogen 2.963 N/A TYR 88.A N TRP 84.A O no hydrogen 2.911 N/A SER 89.A N ILE 85.A O no hydrogen 2.889 N/A SER 89.A N ALA 86.A O no hydrogen 3.225 N/A SER 89.A OG ILE 85.A O no hydrogen 2.354 N/A SER 89.A OG ALA 86.A O no hydrogen 2.967 N/A LEU 90.A N ALA 86.A O no hydrogen 2.971 N/A ARG 92.A NH1 TYR 88.A OH no hydrogen 2.494 N/A ARG 92.A NH2 GLN 279.A O no hydrogen 2.853 N/A ALA 93.A N SER 89.A O no hydrogen 2.989 N/A MET 94.A N LEU 90.A O no hydrogen 2.993 N/A LYS 95.A N PRO 91.A O no hydrogen 2.888 N/A ARG 96.A N ARG 92.A O no hydrogen 2.903 N/A LEU 97.A N ALA 93.A O no hydrogen 2.938 N/A GLU 98.A N MET 94.A O no hydrogen 2.935 N/A GLU 99.A N LYS 95.A O no hydrogen 2.890 N/A ALA 100.A N ARG 96.A O no hydrogen 2.921 N/A ARG 101.A N LEU 97.A O no hydrogen 2.920 N/A LEU 102.A N GLU 98.A O no hydrogen 2.918 N/A HIS 103.A N GLU 99.A O no hydrogen 2.894 N/A LYS 104.A N ALA 100.A O no hydrogen 2.927 N/A ARG 111.A NH1 LYS 104.A O no hydrogen 2.647 N/A THR 112.A N GLU 108.A O no hydrogen 2.927 N/A THR 112.A OG1 GLU 108.A O no hydrogen 3.412 N/A THR 112.A OG1 THR 109.A O no hydrogen 2.618 N/A SER 113.A N THR 109.A O no hydrogen 2.914 N/A GLN 114.A N THR 110.A O no hydrogen 2.902 N/A MET 115.A N ARG 111.A O no hydrogen 2.912 N/A GLN 116.A N THR 112.A O no hydrogen 2.906 N/A GLU 117.A N SER 113.A O no hydrogen 2.899 N/A LEU 118.A N GLN 114.A O no hydrogen 2.912 N/A HIS 119.A N MET 115.A O no hydrogen 2.889 N/A LYS 120.A N GLN 116.A O no hydrogen 2.930 N/A LYS 120.A NZ GLU 117.A OE1 no hydrogen 3.365 N/A SER 121.A N GLU 117.A O no hydrogen 2.921 N/A SER 121.A OG GLU 117.A O no hydrogen 3.218 N/A SER 121.A OG LEU 118.A O no hydrogen 2.427 N/A LEU 122.A N LEU 118.A O no hydrogen 2.907 N/A ARG 123.A N HIS 119.A O no hydrogen 2.894 N/A SER 124.A N LYS 120.A O no hydrogen 2.943 N/A SER 124.A OG LYS 120.A O no hydrogen 3.429 N/A SER 124.A OG SER 121.A O no hydrogen 2.984 N/A SER 124.A OG SER 124.A O no hydrogen 2.501 N/A ASN 126.A N MET 424.A O no hydrogen 2.885 N/A PHE 128.A N LEU 422.A O no hydrogen 2.871 N/A CYS 129.A SG ASP 166.A O no hydrogen 3.905 N/A GLN 131.A N PHE 420.A O no hydrogen 3.122 N/A GLY 133.A N ARG 418.A O no hydrogen 2.923 N/A ASP 135.A N ASP 134.A OD1 no hydrogen 2.359 N/A ILE 138.A N SER 415.A O no hydrogen 3.239 N/A SER 139.A N ALA 153.A O no hydrogen 3.113 N/A SER 139.A OG VAL 180.A O no hydrogen 3.098 N/A SER 139.A OG GLY 181.A O no hydrogen 3.355 N/A CYS 141.A SG ALA 412.A O no hydrogen 3.727 N/A HIS 142.A N ALA 151.A O no hydrogen 2.894 N/A PHE 143.A N ASP 403.A OD2 no hydrogen 2.724 N/A SER 144.A N MET 149.A O no hydrogen 2.938 N/A SER 144.A OG MET 149.A O no hydrogen 2.795 N/A SER 147.A N SER 144.A O no hydrogen 2.815 N/A SER 147.A OG ASN 146.A O no hydrogen 2.862 N/A SER 147.A OG ASP 407.A OD2 no hydrogen 2.787 N/A LYS 148.A N ASN 146.A OD1 no hydrogen 2.836 N/A MET 149.A N SER 144.A OG no hydrogen 2.948 N/A LEU 150.A N TRP 162.A O no hydrogen 2.907 N/A ALA 151.A N HIS 142.A O no hydrogen 2.905 N/A THR 152.A N LYS 160.A O no hydrogen 2.898 N/A ALA 153.A N TYR 140.A O no hydrogen 2.896 N/A CYS 154.A SG ARG 136.A O no hydrogen 3.235 N/A CYS 154.A SG PRO 137.A O no hydrogen 3.129 N/A CYS 154.A SG SER 156.A OG no hydrogen 3.362 N/A TRP 155.A N PRO 137.A O no hydrogen 2.884 N/A SER 156.A OG ASP 134.A OD2 no hydrogen 3.289 N/A CYS 159.A N LEU 173.A O no hydrogen 3.453 N/A LYS 160.A N THR 152.A O no hydrogen 2.927 N/A TRP 162.A N LEU 150.A O no hydrogen 2.877 N/A SER 163.A N ASN 168.A O no hydrogen 2.907 N/A SER 163.A OG ASN 168.A O no hydrogen 3.484 N/A VAL 164.A N LYS 148.A O no hydrogen 2.987 N/A CYS 167.A N SER 163.A O no hydrogen 2.492 N/A CYS 167.A SG PRO 165.A O no hydrogen 3.563 N/A ASN 168.A N SER 163.A OG no hydrogen 3.068 N/A LEU 170.A N LEU 161.A O no hydrogen 2.667 N/A LEU 173.A N CYS 159.A O no hydrogen 2.878 N/A ARG 174.A N ASP 217.A O no hydrogen 3.377 N/A HIS 176.A NE2 SER 202.A OG no hydrogen 2.516 N/A THR 178.A OG1 ASP 206.A OD2 no hydrogen 2.604 N/A VAL 180.A N CYS 154.A O no hydrogen 3.268 N/A GLY 181.A N CYS 203.A O no hydrogen 2.824 N/A VAL 184.A N ALA 201.A O no hydrogen 2.907 N/A PHE 185.A N HIS 142.A ND1 no hydrogen 3.320 N/A HIS 186.A N ASN 199.A O no hydrogen 2.535 N/A SER 189.A N HIS 186.A O no hydrogen 3.121 N/A SER 189.A OG ASN 199.A OD1 no hydrogen 3.266 N/A THR 190.A OG1 PRO 145.A O no hydrogen 2.090 N/A SER 192.A N LYS 188.A O no hydrogen 3.476 N/A SER 192.A OG SER 192.A O no hydrogen 2.200 N/A LYS 196.A NZ ASP 194.A OD2 no hydrogen 3.260 N/A ASP 197.A N ASP 194.A O no hydrogen 3.144 N/A VAL 198.A N ASP 197.A OD1 no hydrogen 2.491 N/A ASN 199.A N TRP 212.A O no hydrogen 2.737 N/A ASN 199.A ND2 ASP 194.A O no hydrogen 3.405 N/A ASN 199.A ND2 ASP 197.A O no hydrogen 2.539 N/A LEU 200.A N TRP 212.A O no hydrogen 2.930 N/A ALA 201.A N VAL 184.A O no hydrogen 2.916 N/A SER 202.A N LYS 210.A O no hydrogen 2.927 N/A SER 202.A OG HIS 176.A NE2 no hydrogen 2.516 N/A CYS 203.A N ALA 182.A O no hydrogen 3.265 N/A CYS 203.A SG ALA 182.A O no hydrogen 3.875 N/A CYS 203.A SG VAL 230.A O no hydrogen 3.916 N/A CYS 203.A SG ALA 231.A O no hydrogen 3.999 N/A ALA 204.A N SER 208.A O no hydrogen 3.234 N/A ALA 205.A N ASN 179.A O no hydrogen 2.507 N/A ASP 206.A N THR 178.A OG1 no hydrogen 3.367 N/A LYS 210.A N SER 202.A O no hydrogen 2.903 N/A LYS 210.A NZ ASP 222.A OD2 no hydrogen 2.951 N/A TRP 212.A N LEU 200.A O no hydrogen 2.861 N/A TRP 212.A NE1 SER 202.A OG no hydrogen 3.126 N/A SER 213.A OG ASP 197.A O no hydrogen 2.311 N/A LEU 214.A N PRO 195.A O no hydrogen 2.917 N/A SER 216.A OG GLU 218.A O no hydrogen 2.941 N/A GLU 218.A N SER 216.A OG no hydrogen 3.395 N/A VAL 220.A N LEU 211.A O no hydrogen 2.800 N/A ILE 223.A N VAL 209.A O no hydrogen 3.277 N/A ALA 231.A N THR 245.A O no hydrogen 2.929 N/A ARG 232.A N THR 245.A OG1 no hydrogen 3.162 N/A MET 234.A N GLY 243.A O no hydrogen 3.080 N/A TRP 235.A NE1 VAL 184.A O no hydrogen 3.192 N/A HIS 236.A N PHE 241.A O no hydrogen 3.007 N/A HIS 236.A NE2 GLY 281.A O no hydrogen 3.012 N/A SER 238.A N HIS 236.A ND1 no hydrogen 3.278 N/A GLY 239.A N HIS 236.A O no hydrogen 2.728 N/A ARG 240.A N SER 238.A OG no hydrogen 3.133 N/A ARG 240.A NH2 ASP 255.A OD1 no hydrogen 3.252 N/A ARG 240.A NH2 ASP 255.A OD2 no hydrogen 2.863 N/A LEU 242.A N TRP 254.A O no hydrogen 2.892 N/A GLY 243.A N MET 234.A O no hydrogen 2.756 N/A THR 244.A N ARG 252.A O no hydrogen 2.939 N/A THR 245.A OG1 TYR 273.A O no hydrogen 3.074 N/A CYS 246.A N SER 250.A O no hydrogen 2.954 N/A CYS 246.A SG VAL 228.A O no hydrogen 4.027 N/A CYS 246.A SG ARG 229.A O no hydrogen 3.861 N/A TYR 247.A N ARG 229.A O no hydrogen 3.137 N/A TRP 251.A N GLN 265.A O no hydrogen 2.941 N/A ARG 252.A N THR 244.A O no hydrogen 2.866 N/A ARG 252.A NE GLY 225.A O no hydrogen 3.056 N/A LEU 253.A N LEU 263.A O no hydrogen 2.920 N/A TRP 254.A N LEU 242.A O no hydrogen 2.886 N/A ASP 255.A N GLU 260.A O no hydrogen 3.302 N/A LEU 256.A N ARG 240.A O no hydrogen 2.858 N/A GLU 260.A N ASP 255.A O no hydrogen 3.265 N/A ILE 262.A N LEU 253.A O no hydrogen 3.045 N/A GLN 265.A N TRP 251.A O no hydrogen 2.902 N/A HIS 268.A ND1 ASP 290.A OD2 no hydrogen 3.249 N/A SER 269.A N ASP 290.A OD2 no hydrogen 2.950 N/A VAL 272.A N CYS 246.A O no hydrogen 3.292 N/A TYR 273.A N GLY 287.A O no hydrogen 3.090 N/A ASP 274.A N GLY 287.A O no hydrogen 2.925 N/A ALA 276.A N GLY 285.A O no hydrogen 2.893 N/A HIS 278.A N LEU 283.A O no hydrogen 2.953 N/A GLN 279.A N HIS 278.A ND1 no hydrogen 2.977 N/A GLY 281.A N HIS 278.A O no hydrogen 2.867 N/A SER 282.A OG ASP 280.A OD1 no hydrogen 3.042 N/A ALA 284.A N TRP 296.A O no hydrogen 2.908 N/A GLY 285.A N ALA 276.A O no hydrogen 2.887 N/A THR 286.A N ARG 294.A O no hydrogen 2.889 N/A GLY 287.A N ASP 274.A O no hydrogen 2.880 N/A LEU 289.A N GLY 271.A O no hydrogen 2.786 N/A PHE 292.A N ASP 290.A OD1 no hydrogen 2.841 N/A GLY 293.A N LEU 307.A O no hydrogen 3.327 N/A ARG 294.A N THR 286.A O no hydrogen 2.892 N/A VAL 295.A N MET 305.A O no hydrogen 3.213 N/A TRP 296.A N ALA 284.A O no hydrogen 2.900 N/A ASP 297.A N GLY 301.A O no hydrogen 3.242 N/A LEU 298.A N SER 282.A O no hydrogen 3.096 N/A ARG 299.A NE ASP 297.A OD1 no hydrogen 3.208 N/A ARG 299.A NH2 ASP 297.A OD1 no hydrogen 2.873 N/A THR 300.A N ASP 297.A O no hydrogen 3.098 N/A ILE 304.A N VAL 295.A O no hydrogen 3.031 N/A LEU 307.A N GLY 293.A O no hydrogen 3.255 N/A HIS 310.A ND1 ASP 332.A OD2 no hydrogen 3.105 N/A HIS 310.A NE2 THR 328.A OG1 no hydrogen 2.909 N/A GLU 313.A N GLU 313.A OE1 no hydrogen 2.827 N/A ILE 314.A N GLY 288.A O no hydrogen 3.162 N/A TYR 315.A N GLY 329.A O no hydrogen 2.884 N/A GLY 316.A N GLY 329.A O no hydrogen 3.282 N/A ASN 318.A N ALA 327.A O no hydrogen 3.068 N/A SER 320.A N HIS 325.A O no hydrogen 3.296 N/A ILE 326.A N TRP 338.A O no hydrogen 2.899 N/A ALA 327.A N ASN 318.A O no hydrogen 3.159 N/A THR 328.A N LYS 336.A O no hydrogen 2.946 N/A THR 328.A OG1 HIS 310.A NE2 no hydrogen 2.909 N/A GLY 329.A N GLY 316.A O no hydrogen 3.126 N/A SER 330.A OG HIS 310.A ND1 no hydrogen 2.924 N/A SER 330.A OG ASP 332.A OD1 no hydrogen 2.433 N/A GLY 331.A N GLU 313.A O no hydrogen 2.908 N/A ASP 332.A N SER 330.A OG no hydrogen 3.167 N/A THR 334.A N ASP 332.A OD1 no hydrogen 3.150 N/A THR 334.A OG1 ASP 332.A OD1 no hydrogen 3.169 N/A CYS 335.A N ILE 349.A O no hydrogen 2.935 N/A CYS 335.A SG THR 328.A O no hydrogen 3.596 N/A LYS 336.A N THR 328.A O no hydrogen 2.885 N/A LYS 336.A NZ THR 348.A OG1 no hydrogen 2.725 N/A VAL 337.A N TYR 347.A O no hydrogen 2.898 N/A TRP 338.A N ILE 326.A O no hydrogen 2.878 N/A ASP 339.A N ARG 344.A O no hydrogen 2.986 N/A LEU 340.A N TYR 324.A O no hydrogen 2.774 N/A ARG 341.A N ASP 339.A OD1 no hydrogen 3.062 N/A ARG 344.A N ASP 339.A O no hydrogen 3.405 N/A ARG 344.A NH1 GLN 342.A OE1 no hydrogen 2.627 N/A CYS 345.A SG VAL 337.A O no hydrogen 3.870 N/A CYS 345.A SG TYR 347.A O no hydrogen 3.396 N/A VAL 346.A N VAL 337.A O no hydrogen 2.806 N/A TYR 347.A N VAL 337.A O no hydrogen 2.972 N/A ILE 349.A N CYS 335.A O no hydrogen 2.843 N/A HIS 352.A NE2 THR 371.A OG1 no hydrogen 2.875 N/A LEU 355.A N ASN 354.A OD1 no hydrogen 2.936 N/A VAL 356.A N SER 330.A O no hydrogen 3.162 N/A THR 357.A N GLY 372.A O no hydrogen 2.868 N/A THR 357.A OG1 VAL 399.A O no hydrogen 3.337 N/A GLY 358.A N GLY 372.A O no hydrogen 3.419 N/A LYS 360.A N LEU 370.A O no hydrogen 2.852 N/A PHE 361.A N ASN 318.A OD1 no hydrogen 3.156 N/A GLU 362.A N PHE 368.A O no hydrogen 3.051 N/A ASN 367.A N GLU 362.A OE1 no hydrogen 2.835 N/A LEU 369.A N TRP 381.A O no hydrogen 2.907 N/A LEU 370.A N LYS 360.A O no hydrogen 2.985 N/A THR 371.A N LYS 379.A O no hydrogen 2.913 N/A THR 371.A OG1 HIS 352.A NE2 no hydrogen 2.875 N/A THR 371.A OG1 LYS 379.A O no hydrogen 3.485 N/A GLY 372.A N GLY 358.A O no hydrogen 3.166 N/A TYR 374.A N LEU 355.A O no hydrogen 2.932 N/A THR 377.A OG1 ASP 375.A OD2 no hydrogen 3.163 N/A ALA 378.A N LEU 392.A O no hydrogen 2.919 N/A LYS 379.A N THR 371.A O no hydrogen 2.872 N/A LYS 379.A NZ ALA 351.A O no hydrogen 2.711 N/A ILE 380.A N LYS 390.A O no hydrogen 2.868 N/A TRP 381.A N LEU 369.A O no hydrogen 2.893 N/A TRP 381.A NE1 THR 371.A OG1 no hydrogen 2.968 N/A THR 382.A N SER 387.A O no hydrogen 3.156 N/A LYS 390.A N ILE 380.A O no hydrogen 2.965 N/A LEU 392.A N ALA 378.A O no hydrogen 2.852 N/A HIS 395.A NE2 THR 413.A OG1 no hydrogen 2.671 N/A MET 400.A N CYS 414.A O no hydrogen 3.398 N/A ASP 403.A N ALA 412.A O no hydrogen 2.907 N/A ILE 404.A N ASP 403.A OD1 no hydrogen 2.517 N/A SER 405.A N LEU 410.A O no hydrogen 2.858 N/A SER 405.A OG ASP 407.A OD1 no hydrogen 2.954 N/A SER 405.A OG LEU 410.A O no hydrogen 2.463 N/A GLY 408.A N SER 405.A O no hydrogen 2.640 N/A GLN 409.A N ASP 407.A OD1 no hydrogen 3.206 N/A GLN 409.A NE2 ASP 407.A OD2 no hydrogen 3.028 N/A ILE 411.A N TRP 423.A O no hydrogen 2.927 N/A ALA 412.A N ASP 403.A O no hydrogen 2.926 N/A THR 413.A N LYS 421.A O no hydrogen 3.003 N/A THR 413.A OG1 HIS 395.A NE2 no hydrogen 2.671 N/A CYS 414.A N GLY 401.A O no hydrogen 2.993 N/A CYS 414.A SG GLY 401.A O no hydrogen 3.205 N/A SER 415.A OG LYS 398.A O no hydrogen 3.277 N/A TYR 416.A N LYS 398.A O no hydrogen 2.800 N/A ASP 417.A N SER 415.A OG no hydrogen 2.632 N/A ARG 418.A N SER 415.A O no hydrogen 3.305 N/A PHE 420.A N GLN 131.A O no hydrogen 3.072 N/A LYS 421.A N THR 413.A O no hydrogen 2.900 N/A LYS 421.A NZ THR 419.A OG1 no hydrogen 3.323 N/A LEU 422.A N PHE 128.A O no hydrogen 3.000 N/A TRP 423.A N ILE 411.A O no hydrogen 2.844 N/A MET 424.A N ASN 126.A O no hydrogen 2.935 N/A