Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8hix_R.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): CYS 4.A SG LEU 65.A O no hydrogen 3.671 N/A LEU 5.A N VAL 1.A O no hydrogen 2.714 N/A LEU 6.A N ASN 2.A O no hydrogen 2.967 N/A GLU 7.A N PHE 3.A O no hydrogen 2.904 N/A VAL 8.A N CYS 4.A O no hydrogen 2.940 N/A LEU 9.A N LEU 5.A O no hydrogen 2.906 N/A ILE 10.A N LEU 6.A O no hydrogen 2.979 N/A ILE 11.A N GLU 7.A O no hydrogen 2.921 N/A VAL 12.A N VAL 8.A O no hydrogen 2.894 N/A PHE 13.A N LEU 9.A O no hydrogen 2.917 N/A LEU 14.A N ILE 10.A O no hydrogen 2.948 N/A THR 15.A N ILE 11.A O no hydrogen 2.892 N/A THR 15.A OG1 GLY 55.A O no hydrogen 3.520 N/A VAL 16.A N VAL 12.A O no hydrogen 3.010 N/A ILE 18.A N LEU 14.A O no hydrogen 2.954 N/A ILE 19.A N THR 15.A O no hydrogen 2.929 N/A SER 20.A N VAL 16.A O no hydrogen 2.972 N/A GLY 21.A N LEU 17.A O no hydrogen 2.916 N/A ASN 22.A N ILE 18.A O no hydrogen 2.999 N/A ASN 22.A ND2 ILE 18.A O no hydrogen 2.397 N/A ILE 23.A N ILE 19.A O no hydrogen 2.929 N/A ILE 24.A N SER 20.A O no hydrogen 2.953 N/A VAL 25.A N GLY 21.A O no hydrogen 2.941 N/A ILE 26.A N ASN 22.A O no hydrogen 2.914 N/A PHE 27.A N ILE 23.A O no hydrogen 2.954 N/A VAL 28.A N ILE 24.A O no hydrogen 2.901 N/A PHE 29.A N VAL 25.A O no hydrogen 2.901 N/A HIS 30.A N ILE 26.A O no hydrogen 2.914 N/A CYS 31.A N PHE 27.A O no hydrogen 2.932 N/A CYS 31.A N VAL 28.A O no hydrogen 3.242 N/A CYS 31.A SG PHE 27.A O no hydrogen 3.306 N/A ASN 36.A N ASN 36.A OD1 no hydrogen 2.584 N/A HIS 37.A N ASN 36.A OD1 no hydrogen 2.775 N/A HIS 38.A NE2 LEU 34.A O no hydrogen 3.097 N/A THR 39.A OG1 ASP 102.A OD2 no hydrogen 3.534 N/A THR 39.A OG1 TYR 113.A OH no hydrogen 2.397 N/A ILE 44.A N THR 40.A O no hydrogen 2.957 N/A GLN 45.A N SER 41.A O no hydrogen 2.858 N/A THR 46.A N TYR 42.A O no hydrogen 2.915 N/A THR 46.A OG1 TYR 42.A O no hydrogen 3.002 N/A MET 47.A N PHE 43.A O no hydrogen 2.919 N/A ALA 48.A N ILE 44.A O no hydrogen 2.945 N/A TYR 49.A N GLN 45.A O no hydrogen 2.873 N/A ALA 50.A N THR 46.A O no hydrogen 2.846 N/A ASP 51.A N MET 47.A O no hydrogen 2.939 N/A LEU 52.A N ALA 48.A O no hydrogen 2.898 N/A PHE 53.A N TYR 49.A O no hydrogen 2.917 N/A VAL 54.A N ALA 50.A O no hydrogen 2.849 N/A GLY 55.A N ASP 51.A O no hydrogen 2.939 N/A VAL 56.A N LEU 52.A O no hydrogen 2.930 N/A SER 57.A N PHE 53.A O no hydrogen 2.889 N/A SER 57.A OG PHE 53.A O no hydrogen 2.702 N/A CYS 58.A N VAL 54.A O no hydrogen 2.820 N/A CYS 58.A SG VAL 54.A O no hydrogen 3.202 N/A LEU 63.A N VAL 59.A O no hydrogen 3.367 N/A SER 64.A N VAL 60.A O no hydrogen 2.935 N/A SER 64.A OG VAL 60.A O no hydrogen 3.030 N/A SER 64.A OG PRO 61.A O no hydrogen 2.886 N/A LEU 65.A N PRO 61.A O no hydrogen 2.901 N/A LEU 66.A N SER 62.A O no hydrogen 2.922 N/A LEU 66.A N LEU 63.A O no hydrogen 3.239 N/A HIS 67.A N LEU 63.A O no hydrogen 2.592 N/A HIS 68.A N LEU 63.A O no hydrogen 2.469 N/A CYS 78.A SG SER 75.A O no hydrogen 3.605 N/A ILE 80.A N LEU 76.A O no hydrogen 2.712 N/A ILE 80.A N THR 77.A O no hydrogen 3.003 N/A PHE 81.A N THR 77.A O no hydrogen 2.587 N/A GLY 82.A N CYS 78.A O no hydrogen 2.621 N/A VAL 84.A N ILE 80.A O no hydrogen 2.606 N/A VAL 85.A N PHE 81.A O no hydrogen 3.098 N/A VAL 87.A N PHE 83.A O no hydrogen 2.963 N/A LEU 88.A N VAL 84.A O no hydrogen 2.886 N/A LYS 89.A N VAL 85.A O no hydrogen 2.853 N/A LYS 89.A NZ ALA 252.A O no hydrogen 3.435 N/A LYS 89.A NZ ASN 255.A OD1 no hydrogen 2.715 N/A LYS 89.A NZ SER 256.A OG no hydrogen 2.400 N/A SER 90.A N SER 86.A O no hydrogen 3.037 N/A SER 90.A OG SER 133.A OG no hydrogen 2.780 N/A VAL 91.A N VAL 87.A O no hydrogen 2.743 N/A SER 92.A N LEU 88.A O no hydrogen 2.753 N/A MET 93.A N LYS 89.A O no hydrogen 2.768 N/A TRP 94.A N SER 90.A O no hydrogen 3.005 N/A SER 95.A OG VAL 91.A O no hydrogen 3.062 N/A SER 95.A OG SER 92.A O no hydrogen 2.239 N/A LEU 96.A N SER 92.A O no hydrogen 3.109 N/A ALA 97.A N MET 93.A O no hydrogen 3.084 N/A CYS 98.A N TRP 94.A O no hydrogen 2.682 N/A CYS 98.A SG TRP 94.A O no hydrogen 3.187 N/A ILE 99.A N SER 95.A O no hydrogen 2.796 N/A SER 100.A N LEU 96.A O no hydrogen 2.743 N/A SER 100.A OG LEU 96.A O no hydrogen 3.223 N/A ILE 101.A N ALA 97.A O no hydrogen 2.639 N/A ASP 102.A N CYS 98.A O no hydrogen 3.040 N/A ARG 103.A N ILE 99.A O no hydrogen 3.176 N/A ILE 105.A N ILE 101.A O no hydrogen 2.939 N/A ALA 106.A N ASP 102.A O no hydrogen 2.598 N/A ILE 107.A N ARG 103.A O no hydrogen 2.978 N/A ILE 107.A N TYR 104.A O no hydrogen 2.999 N/A THR 108.A N TYR 104.A O no hydrogen 2.695 N/A THR 108.A OG1 TYR 104.A O no hydrogen 2.866 N/A LYS 109.A N ILE 105.A O no hydrogen 2.621 N/A TYR 113.A OH THR 39.A OG1 no hydrogen 2.397 N/A THR 115.A N THR 112.A O no hydrogen 2.921 N/A LEU 116.A N THR 112.A O no hydrogen 2.991 N/A LEU 116.A N TYR 113.A O no hydrogen 2.953 N/A VAL 117.A N TYR 113.A O no hydrogen 2.817 N/A LEU 122.A N THR 118.A O no hydrogen 3.059 N/A ARG 123.A N PRO 119.A O no hydrogen 2.933 N/A LEU 124.A N TRP 120.A O no hydrogen 2.977 N/A CYS 125.A N ARG 121.A O no hydrogen 2.840 N/A ILE 126.A N LEU 122.A O no hydrogen 2.932 N/A PHE 127.A N ARG 123.A O no hydrogen 3.046 N/A LEU 128.A N LEU 124.A O no hydrogen 2.915 N/A ILE 129.A N CYS 125.A O no hydrogen 2.876 N/A TRP 130.A N ILE 126.A O no hydrogen 3.013 N/A LEU 131.A N PHE 127.A O no hydrogen 2.968 N/A TYR 132.A N LEU 128.A O no hydrogen 2.876 N/A TYR 132.A OH MET 174.A O no hydrogen 2.232 N/A SER 133.A N ILE 129.A O no hydrogen 2.959 N/A SER 133.A OG SER 90.A OG no hydrogen 2.780 N/A SER 133.A OG ILE 129.A O no hydrogen 2.756 N/A THR 134.A N TRP 130.A O no hydrogen 2.985 N/A THR 134.A OG1 TRP 130.A O no hydrogen 2.735 N/A LEU 135.A N LEU 131.A O no hydrogen 2.881 N/A VAL 136.A N TYR 132.A O no hydrogen 3.009 N/A LEU 138.A N LEU 135.A O no hydrogen 3.463 N/A SER 140.A N PHE 137.A O no hydrogen 3.295 N/A SER 140.A OG PHE 137.A O no hydrogen 2.249 N/A PHE 141.A N LEU 138.A O no hydrogen 2.933 N/A PHE 142.A N PRO 139.A O no hydrogen 2.916 N/A TRP 144.A N PRO 139.A O no hydrogen 3.417 N/A LYS 146.A NZ ASP 152.A OD1 no hydrogen 3.415 N/A LYS 146.A NZ ALA 158.A O no hydrogen 3.552 N/A LYS 146.A NZ TRP 161.A O no hydrogen 3.325 N/A ASP 152.A N TYR 149.A O no hydrogen 3.397 N/A PHE 154.A N GLY 151.A O no hydrogen 3.195 N/A CYS 157.A N PHE 154.A O no hydrogen 3.244 N/A GLU 159.A N GLU 159.A OE1 no hydrogen 3.199 N/A SER 160.A N TRP 156.A O no hydrogen 3.359 N/A SER 160.A OG TRP 156.A O no hydrogen 2.509 N/A THR 163.A OG1 TYR 149.A OH no hydrogen 3.219 N/A SER 165.A OG SER 235.A O no hydrogen 2.325 N/A SER 165.A OG SER 236.A O no hydrogen 3.473 N/A THR 168.A N ASP 164.A O no hydrogen 2.916 N/A THR 168.A OG1 ASP 164.A O no hydrogen 3.339 N/A THR 168.A OG1 SER 235.A OG no hydrogen 2.693 N/A LEU 169.A N SER 165.A O no hydrogen 2.883 N/A PHE 170.A N TYR 166.A O no hydrogen 2.886 N/A ILE 171.A N PHE 167.A O no hydrogen 2.934 N/A VAL 172.A N THR 168.A O no hydrogen 2.869 N/A MET 174.A N PHE 170.A O no hydrogen 3.195 N/A LEU 175.A N ILE 171.A O no hydrogen 2.668 N/A TYR 176.A N ILE 171.A O no hydrogen 3.243 N/A TYR 176.A N VAL 172.A O no hydrogen 3.065 N/A ALA 177.A N VAL 172.A O no hydrogen 2.627 N/A LEU 181.A N ALA 177.A O no hydrogen 2.888 N/A ILE 182.A N PRO 178.A O no hydrogen 2.920 N/A VAL 183.A N ALA 179.A O no hydrogen 2.984 N/A CYS 184.A N ALA 180.A O no hydrogen 2.861 N/A PHE 185.A N LEU 181.A O no hydrogen 2.958 N/A THR 186.A N ILE 182.A O no hydrogen 2.964 N/A THR 186.A OG1 ILE 182.A O no hydrogen 2.428 N/A THR 186.A OG1 VAL 183.A O no hydrogen 2.970 N/A TYR 187.A N VAL 183.A O no hydrogen 2.934 N/A PHE 188.A N CYS 184.A O no hydrogen 2.922 N/A ASN 189.A N PHE 185.A O no hydrogen 3.016 N/A ILE 190.A N THR 186.A O no hydrogen 2.949 N/A PHE 191.A N TYR 187.A O no hydrogen 2.931 N/A ARG 192.A N PHE 188.A O no hydrogen 2.926 N/A ILE 193.A N ASN 189.A O no hydrogen 3.004 N/A CYS 194.A N ILE 190.A O no hydrogen 2.942 N/A GLN 195.A N PHE 191.A O no hydrogen 2.910 N/A GLN 196.A N ARG 192.A O no hydrogen 3.014 N/A HIS 197.A N ILE 193.A O no hydrogen 2.982 N/A THR 198.A N CYS 194.A O no hydrogen 2.906 N/A THR 198.A OG1 CYS 194.A O no hydrogen 2.476 N/A LYS 199.A N GLN 195.A O no hydrogen 2.902 N/A ASP 200.A N GLN 196.A O no hydrogen 3.040 N/A ILE 201.A N HIS 197.A O no hydrogen 2.935 N/A SER 202.A N THR 198.A O no hydrogen 2.902 N/A SER 202.A OG THR 198.A O no hydrogen 3.018 N/A SER 202.A OG LYS 199.A O no hydrogen 2.731 N/A GLU 203.A N LYS 199.A O no hydrogen 2.907 N/A ARG 204.A N ASP 200.A O no hydrogen 3.022 N/A GLN 205.A N ILE 201.A O no hydrogen 2.915 N/A ALA 206.A N SER 202.A O no hydrogen 2.863 N/A ARG 207.A N GLU 203.A O no hydrogen 2.984 N/A ARG 215.A N MET 211.A O no hydrogen 2.950 N/A ARG 215.A NE MET 211.A O no hydrogen 2.839 N/A ILE 216.A N VAL 212.A O no hydrogen 2.961 N/A THR 217.A N LEU 213.A O no hydrogen 2.997 N/A THR 217.A OG1 LEU 213.A O no hydrogen 3.413 N/A SER 218.A N PHE 214.A O no hydrogen 2.847 N/A SER 218.A OG PHE 214.A O no hydrogen 3.310 N/A SER 218.A OG ARG 215.A O no hydrogen 3.061 N/A VAL 219.A N ARG 215.A O no hydrogen 2.879 N/A PHE 220.A N ILE 216.A O no hydrogen 3.003 N/A TYR 221.A N THR 217.A O no hydrogen 3.000 N/A ILE 222.A N SER 218.A O no hydrogen 2.902 N/A LEU 223.A N VAL 219.A O no hydrogen 2.953 N/A TRP 224.A N TYR 221.A O no hydrogen 3.230 N/A LEU 225.A N TYR 221.A O no hydrogen 2.888 N/A TYR 227.A N TRP 224.A O no hydrogen 3.151 N/A ILE 229.A N LEU 225.A O no hydrogen 2.970 N/A TYR 230.A N PRO 226.A O no hydrogen 2.984 N/A PHE 231.A N TYR 227.A O no hydrogen 2.810 N/A LEU 232.A N ILE 228.A O no hydrogen 2.889 N/A LEU 233.A N ILE 229.A O no hydrogen 2.919 N/A GLU 234.A N TYR 230.A O no hydrogen 2.867 N/A SER 235.A N PHE 231.A O no hydrogen 2.918 N/A SER 235.A OG THR 168.A OG1 no hydrogen 2.693 N/A SER 236.A N LEU 233.A O no hydrogen 3.317 N/A SER 236.A OG LEU 232.A O no hydrogen 2.349 N/A ARG 242.A NH1 GLU 7.A OE2 no hydrogen 2.802 N/A ARG 242.A NH2 GLU 7.A OE1 no hydrogen 3.087 N/A ARG 242.A NH2 GLU 7.A OE2 no hydrogen 2.772 N/A SER 245.A N ASN 241.A O no hydrogen 3.131 N/A SER 245.A OG GLU 234.A OE1 no hydrogen 2.266 N/A SER 245.A OG ASN 241.A O no hydrogen 2.634 N/A PHE 246.A N ARG 242.A O no hydrogen 2.980 N/A LEU 247.A N PHE 243.A O no hydrogen 2.899 N/A THR 248.A N ALA 244.A O no hydrogen 2.891 N/A THR 248.A OG1 ALA 244.A O no hydrogen 2.595 N/A THR 248.A OG1 SER 245.A O no hydrogen 3.016 N/A THR 249.A N SER 245.A O no hydrogen 2.946 N/A THR 249.A OG1 SER 245.A O no hydrogen 2.606 N/A THR 249.A OG1 PHE 246.A O no hydrogen 2.814 N/A TRP 250.A N PHE 246.A O no hydrogen 3.002 N/A LEU 251.A N LEU 247.A O no hydrogen 2.894 N/A ALA 252.A N THR 248.A O no hydrogen 2.903 N/A ILE 253.A N THR 249.A O no hydrogen 2.914 N/A SER 254.A N TRP 250.A O no hydrogen 2.934 N/A SER 254.A N LEU 251.A O no hydrogen 3.151 N/A SER 254.A OG LEU 251.A O no hydrogen 2.270 N/A SER 256.A N ILE 253.A O no hydrogen 3.002 N/A SER 256.A OG ILE 253.A O no hydrogen 2.803 N/A CYS 258.A SG SER 254.A O no hydrogen 3.273 N/A ASN 259.A N ASN 255.A O no hydrogen 2.979 N/A VAL 261.A N PHE 257.A O no hydrogen 3.392 N/A ILE 262.A N CYS 258.A O no hydrogen 2.786 N/A TYR 263.A N ASN 259.A O no hydrogen 2.944 N/A ALA 264.A N PRO 260.A O no hydrogen 2.893 N/A LEU 265.A N VAL 261.A O no hydrogen 2.877 N/A SER 266.A OG ILE 262.A O no hydrogen 2.623 N/A ASP 267.A N TYR 263.A O no hydrogen 3.149 N/A THR 269.A OG1 ASP 267.A OD2 no hydrogen 3.331 N/A PHE 270.A N ASP 267.A OD2 no hydrogen 3.105 N/A GLN 271.A NE2 ALA 264.A O no hydrogen 3.133 N/A ARG 272.A N SER 268.A O no hydrogen 2.930 N/A GLY 273.A N THR 269.A O no hydrogen 2.947 N/A LEU 274.A N PHE 270.A O no hydrogen 2.862 N/A LYS 275.A N GLN 271.A O no hydrogen 2.903 N/A ARG 276.A N ARG 272.A O no hydrogen 2.919 N/A LEU 277.A N GLY 273.A O no hydrogen 2.924 N/A SER 278.A N LEU 274.A O no hydrogen 2.907 N/A GLY 279.A N LYS 275.A O no hydrogen 2.877 N/A ALA 280.A N ARG 276.A O no hydrogen 2.931 N/A MET 281.A N LEU 277.A O no hydrogen 2.882 N/A MET 281.A N SER 278.A O no hydrogen 3.192 N/A CYS 282.A N SER 278.A O no hydrogen 2.895 N/A CYS 282.A SG SER 278.A O no hydrogen 3.238 N/A THR 283.A N GLY 279.A O no hydrogen 2.890 N/A THR 283.A OG1 GLY 279.A O no hydrogen 2.458 N/A