Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8hkn_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): SER 4.A OG ASP 131.A OD1 no hydrogen 2.579 N/A GLN 5.A N ASP 131.A OD2 no hydrogen 3.059 N/A GLN 5.A NE2 GLU 3.A O no hydrogen 2.978 N/A LEU 6.A N SER 4.A OG no hydrogen 3.155 N/A ARG 9.A N ASP 7.A OD1 no hydrogen 2.901 N/A ARG 9.A NE ASP 7.A OD1 no hydrogen 3.367 N/A ARG 9.A NH1 LEU 144.A O no hydrogen 3.282 N/A ARG 9.A NH2 ASP 7.A OD2 no hydrogen 3.467 N/A GLN 11.A N ASP 7.A O no hydrogen 3.011 N/A GLN 11.A NE2 LEU 6.A O no hydrogen 2.592 N/A GLU 12.A N LEU 8.A O no hydrogen 3.058 N/A LEU 13.A N ARG 9.A O no hydrogen 2.972 N/A ILE 14.A N VAL 10.A O no hydrogen 2.909 N/A LYS 15.A N GLN 11.A O no hydrogen 3.042 N/A LEU 16.A N GLU 12.A O no hydrogen 3.038 N/A ILE 17.A N LEU 13.A O no hydrogen 3.079 N/A CYS 18.A N ILE 14.A O no hydrogen 2.998 N/A ASN 19.A N LEU 16.A O no hydrogen 3.384 N/A ALA 22.A N ASN 19.A OD1 no hydrogen 3.086 N/A MET 23.A N ASN 19.A O no hydrogen 3.315 N/A GLU 24.A N VAL 20.A O no hydrogen 2.998 N/A GLU 25.A N GLN 21.A O no hydrogen 3.094 N/A MET 26.A N ALA 22.A O no hydrogen 2.910 N/A MET 27.A N MET 23.A O no hydrogen 2.929 N/A MET 28.A N GLU 24.A O no hydrogen 2.968 N/A GLU 29.A N GLU 25.A O no hydrogen 3.298 N/A MET 30.A N MET 27.A O no hydrogen 3.127 N/A LYS 31.A N MET 28.A O no hydrogen 3.035 N/A TYR 32.A N MET 27.A O no hydrogen 2.866 N/A TYR 32.A OH ALA 37.A O no hydrogen 3.422 N/A ASN 33.A N PRO 82.A O no hydrogen 2.704 N/A THR 34.A OG1 GLU 24.A OE1 no hydrogen 3.359 N/A LYS 36.A N ASN 33.A OD1 no hydrogen 2.879 N/A ALA 37.A N ASN 33.A O no hydrogen 2.931 N/A LYS 41.A N PRO 38.A O no hydrogen 3.111 N/A LEU 42.A N LEU 39.A O no hydrogen 3.172 N/A ALA 45.A N THR 43.A OG1 no hydrogen 2.736 N/A GLN 46.A N THR 43.A OG1 no hydrogen 3.327 N/A GLN 46.A NE2 ARG 80.A O no hydrogen 3.459 N/A ILE 47.A N THR 43.A O no hydrogen 3.130 N/A LYS 48.A N VAL 44.A O no hydrogen 2.740 N/A ALA 49.A N ALA 45.A O no hydrogen 2.890 N/A GLY 50.A N GLN 46.A O no hydrogen 3.058 N/A TYR 51.A N ILE 47.A O no hydrogen 2.976 N/A GLN 52.A N LYS 48.A O no hydrogen 3.040 N/A SER 53.A N ALA 49.A O no hydrogen 3.117 N/A SER 53.A OG ALA 49.A O no hydrogen 3.051 N/A SER 53.A OG GLU 76.A OE2 no hydrogen 2.425 N/A LEU 54.A N GLY 50.A O no hydrogen 3.138 N/A LYS 55.A N TYR 51.A O no hydrogen 2.942 N/A LYS 56.A N GLN 52.A O no hydrogen 3.182 N/A ILE 57.A N SER 53.A O no hydrogen 2.999 N/A GLU 58.A N LEU 54.A O no hydrogen 2.842 N/A ASP 59.A N LYS 55.A O no hydrogen 2.897 N/A CYS 60.A N LYS 56.A O no hydrogen 2.943 N/A CYS 60.A SG LYS 56.A O no hydrogen 3.491 N/A ILE 61.A N ILE 57.A O no hydrogen 2.907 N/A ARG 62.A N GLU 58.A O no hydrogen 2.943 N/A ARG 62.A NH1 ASP 59.A OD1 no hydrogen 2.726 N/A ALA 63.A N ASP 59.A O no hydrogen 3.100 N/A ALA 63.A N CYS 60.A O no hydrogen 3.058 N/A GLY 64.A N ILE 61.A O no hydrogen 3.262 N/A GLN 65.A N CYS 60.A O no hydrogen 2.813 N/A LEU 70.A N GLY 67.A O no hydrogen 3.070 N/A MET 71.A N GLY 67.A O no hydrogen 3.136 N/A GLU 72.A N ARG 68.A O no hydrogen 3.250 N/A ALA 73.A N ALA 69.A O no hydrogen 3.030 N/A CYS 74.A N LEU 70.A O no hydrogen 2.911 N/A CYS 74.A SG LEU 70.A O no hydrogen 3.346 N/A ASN 75.A N MET 71.A O no hydrogen 2.835 N/A GLU 76.A N GLU 72.A O no hydrogen 2.762 N/A PHE 77.A N ALA 73.A O no hydrogen 2.949 N/A TYR 78.A N CYS 74.A O no hydrogen 2.732 N/A TYR 78.A OH PRO 91.A O no hydrogen 2.505 N/A THR 79.A N ASN 75.A O no hydrogen 3.087 N/A THR 79.A N GLU 76.A O no hydrogen 3.096 N/A THR 79.A OG1 ASN 75.A O no hydrogen 3.114 N/A ARG 80.A N GLU 76.A O no hydrogen 2.998 N/A ARG 80.A NH1 ALA 49.A O no hydrogen 3.278 N/A ILE 81.A N PHE 77.A O no hydrogen 2.782 N/A HIS 83.A ND1 ILE 81.A O no hydrogen 2.619 N/A ASP 84.A N LYS 31.A O no hydrogen 2.792 N/A ARG 88.A N PHE 85.A O no hydrogen 3.134 N/A ARG 94.A N GLU 98.A OE1 no hydrogen 2.687 N/A THR 95.A N GLU 98.A OE1 no hydrogen 2.994 N/A GLU 98.A N THR 95.A OG1 no hydrogen 3.258 N/A LEU 99.A N THR 95.A O no hydrogen 2.924 N/A SER 100.A N GLN 96.A O no hydrogen 2.906 N/A GLU 101.A N LYS 97.A O no hydrogen 3.198 N/A LYS 102.A N GLU 98.A O no hydrogen 3.193 N/A LYS 102.A NZ HIS 83.A NE2 no hydrogen 2.990 N/A ILE 103.A N LEU 99.A O no hydrogen 3.011 N/A GLN 104.A N SER 100.A O no hydrogen 2.966 N/A GLN 104.A NE2 SER 100.A O no hydrogen 3.474 N/A LEU 105.A N GLU 101.A O no hydrogen 3.076 N/A LEU 106.A N LYS 102.A O no hydrogen 3.002 N/A GLU 107.A N ILE 103.A O no hydrogen 2.904 N/A ALA 108.A N GLN 104.A O no hydrogen 3.015 N/A LEU 109.A N LEU 105.A O no hydrogen 2.838 N/A GLY 110.A N LEU 106.A O no hydrogen 2.665 N/A ASP 111.A N GLU 107.A O no hydrogen 3.054 N/A ILE 112.A N ALA 108.A O no hydrogen 2.788 N/A GLU 113.A N LEU 109.A O no hydrogen 2.926 N/A ILE 114.A N GLY 110.A O no hydrogen 3.330 N/A ALA 115.A N ASP 111.A O no hydrogen 3.044 N/A ILE 116.A N ILE 112.A O no hydrogen 2.857 N/A LYS 117.A N GLU 113.A O no hydrogen 3.200 N/A LYS 117.A NZ ILE 114.A O no hydrogen 2.759 N/A LEU 118.A N ILE 114.A O no hydrogen 3.005 N/A VAL 119.A N ALA 115.A O no hydrogen 2.653 N/A LYS 120.A N ILE 116.A O no hydrogen 2.979 N/A SER 121.A N LYS 117.A O no hydrogen 3.285 N/A SER 121.A OG LYS 117.A O no hydrogen 3.376 N/A SER 121.A OG LEU 118.A O no hydrogen 2.793 N/A GLU 122.A N VAL 119.A O no hydrogen 3.378 N/A ARG 123.A N GLN 132.A OE1 no hydrogen 3.272 N/A LEU 130.A N HIS 128.A ND1 no hydrogen 3.147 N/A ASP 131.A N HIS 128.A O no hydrogen 3.104 N/A GLN 132.A N HIS 128.A O no hydrogen 3.346 N/A GLN 132.A NE2 GLN 124.A O no hydrogen 2.994 N/A GLN 132.A NE2 GLU 127.A O no hydrogen 2.861 N/A HIS 133.A N PRO 129.A O no hydrogen 3.002 N/A TYR 134.A N LEU 130.A O no hydrogen 2.940 N/A ARG 135.A N ASP 131.A O no hydrogen 3.164 N/A ARG 135.A NH1 GLU 127.A OE2 no hydrogen 3.272 N/A ARG 135.A NH2 GLU 127.A OE1 no hydrogen 2.536 N/A ARG 135.A NH2 GLU 127.A OE2 no hydrogen 3.220 N/A ASN 136.A N GLN 132.A O no hydrogen 2.951 N/A LEU 137.A N HIS 133.A O no hydrogen 3.206 N/A LEU 137.A N TYR 134.A O no hydrogen 2.989 N/A HIS 138.A N ARG 135.A O no hydrogen 3.161 N/A CYS 139.A SG ALA 140.A O no hydrogen 3.894 N/A ALA 140.A N GLU 180.A O no hydrogen 2.796 N/A LEU 141.A N TYR 134.A OH no hydrogen 2.941 N/A ARG 142.A N GLU 178.A O no hydrogen 2.920 N/A ARG 142.A NH2 GLU 180.A OE1 no hydrogen 3.035 N/A LEU 144.A N LEU 176.A O no hydrogen 2.835 N/A SER 148.A N ASP 145.A O no hydrogen 3.010 N/A SER 148.A OG ASP 145.A O no hydrogen 2.500 N/A GLU 150.A N GLU 150.A OE1 no hydrogen 3.174 N/A PHE 151.A N SER 148.A OG no hydrogen 3.037 N/A LYS 152.A N SER 148.A O no hydrogen 3.218 N/A VAL 153.A N TYR 149.A O no hydrogen 2.952 N/A ILE 154.A N GLU 150.A O no hydrogen 2.918 N/A SER 155.A N PHE 151.A O no hydrogen 2.768 N/A GLN 156.A N LYS 152.A O no hydrogen 3.036 N/A TYR 157.A N VAL 153.A O no hydrogen 3.040 N/A TYR 157.A OH LEU 197.A O no hydrogen 2.693 N/A LEU 158.A N ILE 154.A O no hydrogen 2.998 N/A GLN 159.A N SER 155.A O no hydrogen 3.121 N/A GLN 159.A NE2 MET 171.A O no hydrogen 2.887 N/A SER 160.A N GLN 156.A O no hydrogen 2.659 N/A SER 160.A OG GLN 156.A O no hydrogen 2.764 N/A THR 161.A OG1 TYR 157.A O no hydrogen 2.801 N/A THR 161.A OG1 SER 239.A OG no hydrogen 3.199 N/A HIS 162.A N GLN 159.A O no hydrogen 3.221 N/A HIS 162.A NE2 HIS 166.A O no hydrogen 2.470 N/A ALA 163.A N SER 240.A OG no hydrogen 2.926 N/A THR 165.A OG1 TYR 328.A OH no hydrogen 2.741 N/A HIS 166.A N ALA 163.A O no hydrogen 3.252 N/A HIS 166.A ND1 SER 240.A OG no hydrogen 3.105 N/A THR 170.A N ASN 350.A O no hydrogen 2.991 N/A THR 172.A N GLN 348.A O no hydrogen 2.811 N/A LEU 174.A N LYS 346.A O no hydrogen 2.976 N/A ASP 175.A N LYS 346.A O no hydrogen 3.490 N/A PHE 177.A N LEU 344.A O no hydrogen 2.787 N/A GLU 178.A N ARG 142.A O no hydrogen 3.033 N/A VAL 179.A N ARG 342.A O no hydrogen 2.791 N/A GLU 180.A N ALA 140.A O no hydrogen 3.072 N/A ASP 182.A N HIS 138.A O no hydrogen 3.328 N/A GLU 184.A N LYS 181.A O no hydrogen 3.241 N/A ALA 187.A N GLY 183.A O no hydrogen 3.152 N/A ARG 189.A N ASN 337.A O no hydrogen 2.810 N/A ARG 189.A NH2 ASP 191.A OD2 no hydrogen 3.539 N/A ASN 194.A ND2 GLY 265.A O no hydrogen 3.018 N/A ARG 195.A NH2 GLU 190.A O no hydrogen 3.285 N/A MET 196.A N VAL 262.A O no hydrogen 3.034 N/A LEU 197.A N THR 307.A O no hydrogen 3.010 N/A LEU 198.A N SER 260.A O no hydrogen 2.931 N/A TRP 199.A N ALA 236.A O no hydrogen 2.801 N/A HIS 200.A N LEU 258.A O no hydrogen 2.806 N/A HIS 200.A ND1 TYR 234.A O no hydrogen 2.722 N/A SER 205.A OG ASN 206.A OD1 no hydrogen 3.475 N/A ASN 206.A N ARG 203.A O no hydrogen 2.961 N/A ASN 206.A ND2 SER 202.A OG no hydrogen 2.907 N/A ILE 210.A N ASN 206.A O no hydrogen 3.046 N/A LEU 211.A N TRP 207.A O no hydrogen 2.695 N/A SER 212.A N VAL 208.A O no hydrogen 2.755 N/A SER 212.A OG VAL 208.A O no hydrogen 2.639 N/A SER 212.A OG GLY 209.A O no hydrogen 3.422 N/A SER 212.A OG HIS 213.A ND1 no hydrogen 3.220 N/A HIS 213.A N GLY 209.A O no hydrogen 2.789 N/A HIS 213.A ND1 SER 212.A OG no hydrogen 3.220 N/A GLY 214.A N ILE 210.A O no hydrogen 2.851 N/A ARG 216.A NH2 ASP 111.A OD1 no hydrogen 3.137 N/A ALA 222.A N PRO 219.A O no hydrogen 3.174 N/A THR 225.A N GLU 58.A OE2 no hydrogen 2.851 N/A THR 225.A OG1 GLU 58.A OE2 no hydrogen 2.294 N/A GLY 226.A N PRO 223.A O no hydrogen 3.046 N/A TYR 227.A N ILE 224.A O no hydrogen 3.272 N/A PHE 229.A N TYR 234.A OH no hydrogen 2.753 N/A GLY 230.A N TYR 227.A O no hydrogen 3.069 N/A LYS 231.A NZ PRO 219.A O no hydrogen 2.850 N/A LYS 231.A NZ ALA 222.A O no hydrogen 2.553 N/A ILE 233.A N VAL 333.A O no hydrogen 2.743 N/A TYR 234.A OH GLY 230.A O no hydrogen 2.927 N/A PHE 235.A N TYR 331.A O no hydrogen 2.923 N/A ALA 236.A N TRP 199.A O no hydrogen 3.083 N/A SER 239.A N THR 161.A OG1 no hydrogen 3.122 N/A SER 239.A OG LEU 158.A O no hydrogen 2.658 N/A SER 239.A OG THR 161.A OG1 no hydrogen 3.199 N/A SER 240.A OG HIS 166.A ND1 no hydrogen 3.105 N/A LYS 241.A NZ ASN 329.A O no hydrogen 3.241 N/A LYS 241.A NZ GLU 330.A OE2 no hydrogen 3.215 N/A SER 242.A N MET 238.A O no hydrogen 3.476 N/A ALA 243.A N SER 239.A O no hydrogen 2.804 N/A ASN 244.A N SER 240.A O no hydrogen 3.139 N/A TYR 245.A N SER 242.A O no hydrogen 2.801 N/A CYS 246.A N ALA 243.A O no hydrogen 3.069 N/A CYS 246.A SG LEU 256.A O no hydrogen 3.254 N/A PHE 247.A N ASN 244.A O no hydrogen 3.413 N/A SER 249.A N LYS 252.A O no hydrogen 3.006 N/A LYS 252.A N SER 249.A OG no hydrogen 2.906 N/A LYS 252.A NZ GLU 25.A OE1 no hydrogen 2.857 N/A ASN 253.A ND2 PHE 349.A O no hydrogen 3.245 N/A GLY 255.A N VAL 347.A O no hydrogen 2.813 N/A LEU 257.A N LEU 345.A O no hydrogen 3.045 N/A LEU 258.A N HIS 200.A O no hydrogen 2.857 N/A LEU 259.A N TYR 343.A O no hydrogen 2.868 N/A SER 260.A N LEU 198.A O no hydrogen 3.029 N/A GLU 261.A N ARG 340.A O no hydrogen 2.978 N/A VAL 262.A N MET 196.A O no hydrogen 2.795 N/A ALA 263.A N GLN 338.A O no hydrogen 2.778 N/A LEU 264.A N ASN 194.A O no hydrogen 3.232 N/A GLY 265.A N HIS 193.A O no hydrogen 2.923 N/A GLN 266.A N HIS 285.A ND1 no hydrogen 2.881 N/A CYS 267.A SG SER 286.A OG no hydrogen 3.438 N/A ASN 268.A N SER 286.A O no hydrogen 2.690 N/A LEU 270.A N LYS 288.A O no hydrogen 2.715 N/A ASN 274.A N MET 228.A O no hydrogen 2.777 N/A LYS 276.A N ASN 274.A OD1 no hydrogen 3.035 N/A ALA 277.A N ASN 274.A O no hydrogen 2.736 N/A GLY 279.A N LYS 276.A O no hydrogen 3.016 N/A LEU 280.A N ALA 277.A O no hydrogen 3.006 N/A LEU 281.A N GLU 278.A O no hydrogen 3.308 N/A LYS 284.A N LEU 281.A O no hydrogen 3.156 N/A HIS 285.A N GLN 266.A O no hydrogen 3.002 N/A SER 286.A N GLN 266.A O no hydrogen 3.307 N/A SER 286.A OG LEU 264.A O no hydrogen 2.589 N/A SER 286.A OG GLN 266.A O no hydrogen 3.525 N/A THR 287.A N ILE 332.A O no hydrogen 2.975 N/A THR 287.A OG1 TYR 334.A OH no hydrogen 2.934 N/A LYS 288.A N ASN 268.A O no hydrogen 2.650 N/A LYS 288.A NZ TYR 331.A OH no hydrogen 3.371 N/A GLY 289.A N GLU 330.A O no hydrogen 2.931 N/A LEU 290.A N LEU 270.A O no hydrogen 2.854 N/A GLY 291.A N ASN 329.A OD1 no hydrogen 3.131 N/A LYS 292.A N LEU 326.A O no hydrogen 3.043 N/A LYS 292.A NZ ASN 327.A OD1 no hydrogen 3.439 N/A MET 293.A N ASN 327.A O no hydrogen 2.854 N/A ALA 294.A N SER 314.A O no hydrogen 3.155 N/A HIS 299.A N SER 296.A O no hydrogen 3.103 N/A PHE 300.A N SER 297.A O no hydrogen 3.239 N/A LEU 303.A N SER 306.A O no hydrogen 2.672 N/A SER 306.A N LEU 303.A O no hydrogen 3.043 N/A THR 307.A N ARG 195.A O no hydrogen 3.080 N/A VAL 308.A N VAL 301.A O no hydrogen 2.930 N/A LEU 310.A N VAL 308.A O no hydrogen 2.868 N/A GLY 311.A N SER 160.A OG no hydrogen 2.780 N/A SER 314.A N ALA 294.A O no hydrogen 3.019 N/A ILE 318.A N ASP 315.A O no hydrogen 3.383 N/A TYR 324.A N PRO 321.A O no hydrogen 2.908 N/A TYR 328.A OH THR 165.A OG1 no hydrogen 2.741 N/A ASN 329.A ND2 ASP 237.A OD2 no hydrogen 2.873 N/A GLU 330.A N GLY 289.A O no hydrogen 2.904 N/A TYR 331.A N PHE 235.A O no hydrogen 2.988 N/A TYR 331.A OH ASP 237.A OD2 no hydrogen 2.469 N/A ILE 332.A N THR 287.A O no hydrogen 2.942 N/A VAL 333.A N ILE 233.A O no hydrogen 3.222 N/A TYR 334.A OH PHE 229.A O no hydrogen 2.632 N/A TYR 334.A OH THR 287.A OG1 no hydrogen 2.934 N/A ASN 337.A N ASN 335.A OD1 no hydrogen 3.006 N/A GLN 338.A N ASN 335.A O no hydrogen 2.985 N/A GLN 338.A NE2 ALA 263.A O no hydrogen 2.779 N/A GLN 338.A NE2 HIS 285.A O no hydrogen 2.845 N/A VAL 339.A N PRO 336.A O no hydrogen 2.848 N/A ARG 340.A N GLU 261.A O no hydrogen 2.980 N/A MET 341.A N GLU 184.A OE1 no hydrogen 2.750 N/A ARG 342.A N LEU 259.A O no hydrogen 2.969 N/A TYR 343.A N LEU 259.A O no hydrogen 2.982 N/A LEU 344.A N PHE 177.A O no hydrogen 2.732 N/A LEU 345.A N LEU 257.A O no hydrogen 2.916 N/A LYS 346.A N ASP 175.A O no hydrogen 2.851 N/A VAL 347.A N GLY 255.A O no hydrogen 2.810 N/A GLN 348.A N THR 172.A O no hydrogen 2.877 N/A PHE 349.A N ASN 253.A O no hydrogen 2.957 N/A ASN 350.A N THR 170.A O no hydrogen 2.950 N/A ASN 350.A ND2 THR 172.A OG1 no hydrogen 2.660 N/A LEU 352.A N ASP 168.A O no hydrogen 3.156 N/A GLN 353.A N PHE 351.A O no hydrogen 2.940 N/A