Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8hks_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): SER 4.A OG ASP 131.A OD1 no hydrogen 3.109 N/A GLN 5.A N ASP 131.A OD2 no hydrogen 2.791 N/A LEU 6.A N SER 4.A OG no hydrogen 3.183 N/A ARG 9.A N ASP 7.A OD1 no hydrogen 2.724 N/A ARG 9.A NH1 LEU 144.A O no hydrogen 3.052 N/A ARG 9.A NH1 ASP 175.A OD1 no hydrogen 3.285 N/A GLN 11.A N ASP 7.A O no hydrogen 2.828 N/A GLN 11.A NE2 LEU 6.A O no hydrogen 2.671 N/A GLU 12.A N LEU 8.A O no hydrogen 3.217 N/A LEU 13.A N ARG 9.A O no hydrogen 3.204 N/A ILE 14.A N VAL 10.A O no hydrogen 3.025 N/A LYS 15.A N GLN 11.A O no hydrogen 3.139 N/A LYS 15.A NZ GLU 12.A OE2 no hydrogen 2.879 N/A LEU 16.A N GLU 12.A O no hydrogen 3.170 N/A ILE 17.A N LEU 13.A O no hydrogen 3.107 N/A CYS 18.A N ILE 14.A O no hydrogen 2.835 N/A ALA 22.A N ASN 19.A OD1 no hydrogen 3.300 N/A MET 23.A N ASN 19.A O no hydrogen 3.096 N/A GLU 24.A N VAL 20.A O no hydrogen 2.917 N/A GLU 25.A N GLN 21.A O no hydrogen 3.170 N/A MET 26.A N ALA 22.A O no hydrogen 3.075 N/A MET 27.A N MET 23.A O no hydrogen 3.084 N/A MET 28.A N GLU 24.A O no hydrogen 3.162 N/A GLU 29.A N GLU 25.A O no hydrogen 3.225 N/A MET 30.A N MET 26.A O no hydrogen 3.196 N/A LYS 31.A N MET 28.A O no hydrogen 2.930 N/A TYR 32.A N MET 27.A O no hydrogen 2.931 N/A TYR 32.A OH ALA 37.A O no hydrogen 3.227 N/A ASN 33.A N PRO 82.A O no hydrogen 2.897 N/A ASN 33.A ND2 HIS 83.A O no hydrogen 3.556 N/A THR 34.A OG1 GLU 24.A OE2 no hydrogen 3.376 N/A LYS 36.A N ASN 33.A OD1 no hydrogen 2.920 N/A ALA 37.A N ASN 33.A O no hydrogen 3.078 N/A LYS 41.A N PRO 38.A O no hydrogen 2.967 N/A LEU 42.A N LEU 39.A O no hydrogen 3.106 N/A ALA 45.A N THR 43.A OG1 no hydrogen 3.091 N/A GLN 46.A NE2 ARG 80.A O no hydrogen 3.234 N/A ILE 47.A N THR 43.A O no hydrogen 3.216 N/A LYS 48.A N VAL 44.A O no hydrogen 2.951 N/A LYS 48.A NZ GLU 221.A OE1 no hydrogen 3.199 N/A ALA 49.A N ALA 45.A O no hydrogen 2.876 N/A GLY 50.A N GLN 46.A O no hydrogen 3.058 N/A TYR 51.A N ILE 47.A O no hydrogen 3.033 N/A GLN 52.A N LYS 48.A O no hydrogen 3.015 N/A SER 53.A N ALA 49.A O no hydrogen 3.019 N/A SER 53.A OG ALA 49.A O no hydrogen 2.755 N/A SER 53.A OG GLU 76.A OE2 no hydrogen 2.738 N/A LEU 54.A N GLY 50.A O no hydrogen 3.087 N/A LYS 55.A N TYR 51.A O no hydrogen 2.926 N/A LYS 56.A N GLN 52.A O no hydrogen 2.907 N/A LYS 56.A NZ GLU 76.A OE1 no hydrogen 2.749 N/A ILE 57.A N SER 53.A O no hydrogen 2.912 N/A GLU 58.A N LEU 54.A O no hydrogen 2.886 N/A ASP 59.A N LYS 55.A O no hydrogen 2.946 N/A CYS 60.A N LYS 56.A O no hydrogen 2.990 N/A CYS 60.A SG LYS 56.A O no hydrogen 3.540 N/A ILE 61.A N ILE 57.A O no hydrogen 2.832 N/A ARG 62.A N GLU 58.A O no hydrogen 2.943 N/A ALA 63.A N ASP 59.A O no hydrogen 3.071 N/A GLY 64.A N ILE 61.A O no hydrogen 3.084 N/A GLN 65.A N CYS 60.A O no hydrogen 2.759 N/A GLN 65.A NE2 ALA 63.A O no hydrogen 3.491 N/A MET 71.A N GLY 67.A O no hydrogen 2.966 N/A GLU 72.A N ARG 68.A O no hydrogen 2.779 N/A ALA 73.A N ALA 69.A O no hydrogen 2.925 N/A CYS 74.A N LEU 70.A O no hydrogen 2.883 N/A CYS 74.A SG LEU 70.A O no hydrogen 3.515 N/A ASN 75.A N MET 71.A O no hydrogen 2.887 N/A GLU 76.A N GLU 72.A O no hydrogen 3.148 N/A PHE 77.A N ALA 73.A O no hydrogen 3.202 N/A TYR 78.A N CYS 74.A O no hydrogen 2.842 N/A TYR 78.A OH PRO 91.A O no hydrogen 2.619 N/A THR 79.A N ASN 75.A O no hydrogen 2.861 N/A THR 79.A N GLU 76.A O no hydrogen 3.158 N/A THR 79.A OG1 ASN 75.A O no hydrogen 2.256 N/A ARG 80.A N GLU 76.A O no hydrogen 3.011 N/A ILE 81.A N PHE 77.A O no hydrogen 2.638 N/A HIS 83.A ND1 ILE 81.A O no hydrogen 2.637 N/A ASP 84.A N LYS 31.A O no hydrogen 2.665 N/A GLY 86.A N ASP 84.A OD1 no hydrogen 3.279 N/A ARG 88.A N PHE 85.A O no hydrogen 3.410 N/A ARG 94.A N GLU 98.A OE1 no hydrogen 3.044 N/A THR 95.A N GLU 98.A OE1 no hydrogen 2.959 N/A GLN 96.A NE2 GLY 226.A O no hydrogen 3.214 N/A GLU 98.A N THR 95.A OG1 no hydrogen 2.982 N/A LEU 99.A N THR 95.A O no hydrogen 3.007 N/A SER 100.A N GLN 96.A O no hydrogen 2.777 N/A GLU 101.A N LYS 97.A O no hydrogen 3.052 N/A LYS 102.A N GLU 98.A O no hydrogen 3.362 N/A ILE 103.A N LEU 99.A O no hydrogen 2.870 N/A GLN 104.A N SER 100.A O no hydrogen 2.767 N/A GLN 104.A NE2 SER 100.A O no hydrogen 3.451 N/A GLN 104.A NE2 SER 100.A OG no hydrogen 2.783 N/A LEU 105.A N GLU 101.A O no hydrogen 3.023 N/A LEU 106.A N LYS 102.A O no hydrogen 2.885 N/A GLU 107.A N ILE 103.A O no hydrogen 2.851 N/A ALA 108.A N GLN 104.A O no hydrogen 3.127 N/A LEU 109.A N LEU 105.A O no hydrogen 3.008 N/A GLY 110.A N LEU 106.A O no hydrogen 2.842 N/A ASP 111.A N GLU 107.A O no hydrogen 3.160 N/A ILE 112.A N ALA 108.A O no hydrogen 2.773 N/A GLU 113.A N LEU 109.A O no hydrogen 2.945 N/A ILE 114.A N GLY 110.A O no hydrogen 3.311 N/A ALA 115.A N ASP 111.A O no hydrogen 3.054 N/A ILE 116.A N ILE 112.A O no hydrogen 2.966 N/A LYS 117.A N GLU 113.A O no hydrogen 3.106 N/A LEU 118.A N ILE 114.A O no hydrogen 2.982 N/A VAL 119.A N ALA 115.A O no hydrogen 2.914 N/A LYS 120.A N ILE 116.A O no hydrogen 2.827 N/A SER 121.A N LEU 118.A O no hydrogen 2.909 N/A SER 121.A OG LYS 117.A O no hydrogen 2.729 N/A GLU 122.A N VAL 119.A O no hydrogen 3.353 N/A ARG 123.A N GLN 132.A OE1 no hydrogen 2.869 N/A LEU 126.A N ARG 123.A O no hydrogen 3.170 N/A LEU 130.A N HIS 128.A ND1 no hydrogen 3.434 N/A GLN 132.A N HIS 128.A O no hydrogen 3.205 N/A GLN 132.A NE2 ARG 123.A O no hydrogen 2.828 N/A GLN 132.A NE2 GLU 127.A O no hydrogen 3.111 N/A HIS 133.A N PRO 129.A O no hydrogen 2.779 N/A TYR 134.A N LEU 130.A O no hydrogen 3.037 N/A ARG 135.A N ASP 131.A O no hydrogen 3.102 N/A ARG 135.A NH1 GLU 127.A OE2 no hydrogen 2.475 N/A ARG 135.A NH2 GLU 127.A OE1 no hydrogen 3.079 N/A ARG 135.A NH2 GLU 127.A OE2 no hydrogen 3.124 N/A ASN 136.A N GLN 132.A O no hydrogen 3.004 N/A LEU 137.A N HIS 133.A O no hydrogen 3.111 N/A LEU 137.A N TYR 134.A O no hydrogen 3.099 N/A HIS 138.A N ARG 135.A O no hydrogen 3.032 N/A CYS 139.A SG ALA 140.A O no hydrogen 3.859 N/A ALA 140.A N GLU 180.A O no hydrogen 2.893 N/A LEU 141.A N TYR 134.A OH no hydrogen 2.918 N/A ARG 142.A N GLU 178.A O no hydrogen 2.849 N/A ARG 142.A NH1 GLU 178.A OE2 no hydrogen 2.788 N/A ARG 142.A NH1 GLU 180.A OE1 no hydrogen 2.860 N/A ARG 142.A NH2 GLU 180.A OE1 no hydrogen 3.275 N/A LEU 144.A N LEU 176.A O no hydrogen 3.074 N/A HIS 146.A NE2 ASP 175.A OD1 no hydrogen 3.304 N/A SER 148.A N ASP 145.A O no hydrogen 3.249 N/A SER 148.A OG ASP 145.A O no hydrogen 2.457 N/A GLU 150.A N GLU 150.A OE1 no hydrogen 2.980 N/A PHE 151.A N SER 148.A OG no hydrogen 3.175 N/A LYS 152.A N SER 148.A O no hydrogen 3.079 N/A VAL 153.A N TYR 149.A O no hydrogen 2.948 N/A ILE 154.A N GLU 150.A O no hydrogen 2.974 N/A SER 155.A N PHE 151.A O no hydrogen 3.016 N/A GLN 156.A N LYS 152.A O no hydrogen 2.987 N/A TYR 157.A N VAL 153.A O no hydrogen 2.656 N/A TYR 157.A OH LEU 197.A O no hydrogen 2.871 N/A LEU 158.A N ILE 154.A O no hydrogen 2.857 N/A GLN 159.A N SER 155.A O no hydrogen 3.125 N/A GLN 159.A NE2 MET 171.A O no hydrogen 2.614 N/A SER 160.A N GLN 156.A O no hydrogen 2.682 N/A SER 160.A OG GLN 156.A O no hydrogen 2.621 N/A SER 160.A OG TYR 157.A O no hydrogen 3.546 N/A THR 161.A N TYR 157.A O no hydrogen 3.301 N/A THR 161.A OG1 TYR 157.A O no hydrogen 2.604 N/A HIS 162.A N GLN 159.A O no hydrogen 3.466 N/A HIS 162.A NE2 HIS 166.A O no hydrogen 2.921 N/A ALA 163.A N SER 240.A OG no hydrogen 2.650 N/A THR 165.A N TYR 326.A OH no hydrogen 3.333 N/A THR 165.A OG1 TYR 326.A OH no hydrogen 2.697 N/A HIS 166.A ND1 SER 240.A OG no hydrogen 2.870 N/A ASP 168.A N ASP 168.A OD1 no hydrogen 2.510 N/A TYR 169.A OH ASN 244.A OD1 no hydrogen 3.087 N/A THR 170.A N ASN 348.A O no hydrogen 2.900 N/A THR 170.A OG1 ASN 348.A O no hydrogen 3.496 N/A THR 172.A N GLN 346.A O no hydrogen 2.822 N/A LEU 174.A N LYS 344.A O no hydrogen 2.678 N/A ASP 175.A N LYS 344.A O no hydrogen 3.179 N/A LEU 176.A N ASP 175.A OD1 no hydrogen 3.164 N/A PHE 177.A N LEU 342.A O no hydrogen 2.868 N/A GLU 178.A N ARG 142.A O no hydrogen 2.792 N/A VAL 179.A N ARG 340.A O no hydrogen 2.435 N/A GLU 180.A N ALA 140.A O no hydrogen 3.077 N/A LYS 181.A NZ HIS 138.A O no hydrogen 2.228 N/A GLU 184.A N LYS 181.A O no hydrogen 3.162 N/A LYS 185.A NZ GLU 180.A OE2 no hydrogen 2.595 N/A ALA 187.A N GLY 183.A O no hydrogen 3.098 N/A PHE 188.A N GLU 184.A O no hydrogen 2.951 N/A ASP 191.A N ASP 191.A OD1 no hydrogen 2.506 N/A ARG 195.A NH2 GLU 190.A O no hydrogen 3.300 N/A MET 196.A N VAL 262.A O no hydrogen 2.922 N/A LEU 197.A N THR 307.A O no hydrogen 2.934 N/A LEU 198.A N SER 260.A O no hydrogen 2.906 N/A TRP 199.A N ALA 236.A O no hydrogen 2.884 N/A HIS 200.A N LEU 258.A O no hydrogen 2.882 N/A HIS 200.A ND1 TYR 234.A O no hydrogen 2.753 N/A SER 205.A OG ASN 206.A OD1 no hydrogen 2.724 N/A ASN 206.A N ARG 203.A O no hydrogen 3.082 N/A ASN 206.A ND2 SER 202.A OG no hydrogen 2.995 N/A ILE 210.A N ASN 206.A O no hydrogen 2.936 N/A LEU 211.A N TRP 207.A O no hydrogen 2.776 N/A SER 212.A N VAL 208.A O no hydrogen 2.725 N/A SER 212.A OG VAL 208.A O no hydrogen 2.877 N/A SER 212.A OG GLY 209.A O no hydrogen 3.200 N/A SER 212.A OG HIS 213.A ND1 no hydrogen 2.612 N/A HIS 213.A N GLY 209.A O no hydrogen 2.609 N/A HIS 213.A ND1 SER 212.A OG no hydrogen 2.612 N/A GLY 214.A N ILE 210.A O no hydrogen 2.650 N/A ARG 216.A NE GLY 214.A O no hydrogen 2.869 N/A ARG 216.A NH1 ASP 111.A OD1 no hydrogen 3.022 N/A ARG 216.A NH2 ASP 111.A OD1 no hydrogen 2.675 N/A ARG 216.A NH2 ASP 111.A OD2 no hydrogen 3.400 N/A GLU 221.A N GLU 221.A OE1 no hydrogen 2.660 N/A ALA 222.A N PRO 219.A O no hydrogen 3.058 N/A THR 225.A N GLU 58.A OE2 no hydrogen 3.205 N/A THR 225.A OG1 GLU 58.A OE2 no hydrogen 2.698 N/A GLY 226.A N PRO 223.A O no hydrogen 3.270 N/A TYR 227.A N ILE 224.A O no hydrogen 3.142 N/A PHE 229.A N TYR 234.A OH no hydrogen 2.836 N/A GLY 230.A N TYR 227.A O no hydrogen 3.014 N/A LYS 231.A NZ PRO 219.A O no hydrogen 2.596 N/A LYS 231.A NZ ALA 222.A O no hydrogen 2.865 N/A GLY 232.A N GLY 230.A O no hydrogen 2.927 N/A ILE 233.A N VAL 331.A O no hydrogen 2.805 N/A TYR 234.A OH GLY 230.A O no hydrogen 2.780 N/A PHE 235.A N TYR 329.A O no hydrogen 2.683 N/A ALA 236.A N TRP 199.A O no hydrogen 3.353 N/A SER 239.A N THR 161.A OG1 no hydrogen 3.112 N/A SER 239.A OG LEU 158.A O no hydrogen 3.010 N/A SER 240.A OG HIS 166.A ND1 no hydrogen 2.870 N/A LYS 241.A N MET 238.A O no hydrogen 3.064 N/A LYS 241.A NZ TYR 326.A O no hydrogen 3.130 N/A LYS 241.A NZ ASN 327.A O no hydrogen 2.589 N/A LYS 241.A NZ GLU 328.A OE2 no hydrogen 2.895 N/A ALA 243.A N SER 239.A O no hydrogen 2.851 N/A ASN 244.A N SER 240.A O no hydrogen 2.970 N/A TYR 245.A N SER 242.A O no hydrogen 2.908 N/A CYS 246.A N ALA 243.A O no hydrogen 3.049 N/A CYS 246.A SG SER 202.A O no hydrogen 3.893 N/A CYS 246.A SG LEU 256.A O no hydrogen 3.208 N/A PHE 247.A N ASN 244.A O no hydrogen 3.111 N/A SER 249.A N LYS 252.A O no hydrogen 3.059 N/A LYS 252.A N SER 249.A OG no hydrogen 2.963 N/A ASN 253.A ND2 PHE 347.A O no hydrogen 3.431 N/A GLY 255.A N VAL 345.A O no hydrogen 2.909 N/A LEU 257.A N LEU 343.A O no hydrogen 2.857 N/A LEU 258.A N HIS 200.A O no hydrogen 3.081 N/A LEU 259.A N TYR 341.A O no hydrogen 2.805 N/A SER 260.A N LEU 198.A O no hydrogen 2.986 N/A GLU 261.A N ARG 338.A O no hydrogen 2.867 N/A VAL 262.A N MET 196.A O no hydrogen 2.739 N/A ALA 263.A N GLN 336.A O no hydrogen 2.882 N/A LEU 264.A N ASN 194.A O no hydrogen 3.271 N/A GLY 265.A N HIS 193.A O no hydrogen 2.955 N/A GLN 266.A N HIS 285.A ND1 no hydrogen 2.854 N/A CYS 267.A SG SER 286.A OG no hydrogen 3.114 N/A ASN 268.A N SER 286.A O no hydrogen 2.589 N/A LEU 270.A N LYS 288.A O no hydrogen 3.010 N/A LYS 276.A N ASN 274.A OD1 no hydrogen 3.039 N/A ALA 277.A N ASN 274.A O no hydrogen 3.040 N/A GLY 279.A N LYS 276.A O no hydrogen 3.339 N/A LEU 280.A N ALA 277.A O no hydrogen 3.100 N/A LEU 281.A N GLU 278.A O no hydrogen 3.440 N/A LYS 284.A N LEU 281.A O no hydrogen 3.164 N/A LYS 284.A NZ ASN 268.A OD1 no hydrogen 3.308 N/A HIS 285.A N GLN 266.A O no hydrogen 3.030 N/A SER 286.A OG LEU 264.A O no hydrogen 3.047 N/A THR 287.A N ILE 330.A O no hydrogen 3.029 N/A THR 287.A OG1 TYR 332.A OH no hydrogen 2.985 N/A LYS 288.A N ASN 268.A O no hydrogen 2.941 N/A LYS 288.A NZ TYR 329.A OH no hydrogen 3.274 N/A GLY 289.A N GLU 328.A O no hydrogen 2.832 N/A LEU 290.A N LEU 270.A O no hydrogen 2.897 N/A GLY 291.A N ASN 327.A OD1 no hydrogen 2.723 N/A LYS 292.A N LEU 324.A O no hydrogen 2.887 N/A MET 293.A N ASN 325.A O no hydrogen 2.922 N/A ALA 294.A N SER 314.A O no hydrogen 2.944 N/A HIS 299.A N SER 296.A O no hydrogen 3.114 N/A PHE 300.A N SER 297.A O no hydrogen 3.358 N/A VAL 301.A N VAL 308.A O no hydrogen 3.379 N/A LEU 303.A N SER 306.A O no hydrogen 2.987 N/A ASN 304.A ND2 GLU 150.A OE2 no hydrogen 2.993 N/A ASN 304.A ND2 TYR 341.A OH no hydrogen 2.857 N/A THR 307.A N ARG 195.A O no hydrogen 3.003 N/A VAL 308.A N VAL 301.A O no hydrogen 2.724 N/A LEU 310.A N VAL 308.A O no hydrogen 2.830 N/A GLY 311.A N SER 160.A OG no hydrogen 2.973 N/A SER 314.A N ALA 294.A O no hydrogen 2.933 N/A SER 314.A OG ASP 315.A O no hydrogen 3.259 N/A THR 316.A N LYS 292.A O no hydrogen 2.506 N/A THR 316.A OG1 GLY 291.A O no hydrogen 2.919 N/A THR 316.A OG1 LYS 292.A O no hydrogen 2.875 N/A TYR 326.A OH THR 165.A OG1 no hydrogen 2.697 N/A ASN 327.A ND2 ASP 237.A OD2 no hydrogen 2.859 N/A GLU 328.A N GLY 289.A O no hydrogen 3.137 N/A TYR 329.A N PHE 235.A O no hydrogen 2.820 N/A TYR 329.A OH ASP 237.A OD2 no hydrogen 2.877 N/A ILE 330.A N THR 287.A O no hydrogen 2.929 N/A VAL 331.A N ILE 233.A O no hydrogen 3.147 N/A TYR 332.A OH PHE 229.A O no hydrogen 2.483 N/A TYR 332.A OH THR 287.A OG1 no hydrogen 2.985 N/A ASN 335.A N ASN 333.A OD1 no hydrogen 3.000 N/A GLN 336.A N ASN 333.A O no hydrogen 3.077 N/A GLN 336.A NE2 ALA 263.A O no hydrogen 2.692 N/A GLN 336.A NE2 HIS 285.A O no hydrogen 3.042 N/A VAL 337.A N PRO 334.A O no hydrogen 3.005 N/A ARG 338.A N GLU 261.A O no hydrogen 3.029 N/A ARG 338.A NH1 GLU 261.A OE1 no hydrogen 3.326 N/A MET 339.A N GLU 184.A OE1 no hydrogen 2.725 N/A ARG 340.A N LEU 259.A O no hydrogen 3.172 N/A ARG 340.A NE GLU 261.A OE2 no hydrogen 3.204 N/A TYR 341.A N LEU 259.A O no hydrogen 3.088 N/A LEU 342.A N PHE 177.A O no hydrogen 2.747 N/A LEU 343.A N LEU 257.A O no hydrogen 2.647 N/A LYS 344.A N ASP 175.A O no hydrogen 2.859 N/A VAL 345.A N GLY 255.A O no hydrogen 2.810 N/A GLN 346.A N THR 172.A O no hydrogen 2.785 N/A GLN 346.A NE2 ASN 348.A OD1 no hydrogen 2.723 N/A PHE 347.A N ASN 253.A O no hydrogen 2.647 N/A ASN 348.A N THR 170.A O no hydrogen 2.786 N/A ASN 348.A ND2 THR 170.A OG1 no hydrogen 3.367 N/A ASN 348.A ND2 THR 172.A OG1 no hydrogen 2.847 N/A LEU 350.A N ASP 168.A O no hydrogen 3.197 N/A