Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8hlq_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): SER 4.A OG ASP 131.A OD1 no hydrogen 2.728 N/A GLN 5.A N ASP 131.A OD2 no hydrogen 3.031 N/A ARG 9.A N ASP 7.A OD1 no hydrogen 2.814 N/A ARG 9.A NE ASP 175.A OD1 no hydrogen 3.305 N/A ARG 9.A NH2 ASP 175.A OD1 no hydrogen 3.424 N/A GLN 11.A N ASP 7.A O no hydrogen 2.813 N/A GLN 11.A NE2 LEU 6.A O no hydrogen 3.065 N/A GLU 12.A N LEU 8.A O no hydrogen 2.949 N/A LEU 13.A N ARG 9.A O no hydrogen 3.107 N/A ILE 14.A N VAL 10.A O no hydrogen 2.856 N/A LYS 15.A N GLN 11.A O no hydrogen 2.868 N/A LEU 16.A N GLU 12.A O no hydrogen 2.939 N/A LEU 16.A N LEU 13.A O no hydrogen 3.109 N/A ILE 17.A N LEU 13.A O no hydrogen 3.041 N/A CYS 18.A N ILE 14.A O no hydrogen 3.161 N/A ALA 22.A N ASN 19.A O no hydrogen 3.122 N/A MET 23.A N ASN 19.A O no hydrogen 3.296 N/A GLU 24.A N VAL 20.A O no hydrogen 3.087 N/A GLU 25.A N GLN 21.A O no hydrogen 3.276 N/A MET 26.A N ALA 22.A O no hydrogen 3.110 N/A MET 27.A N MET 23.A O no hydrogen 2.975 N/A MET 28.A N GLU 24.A O no hydrogen 2.813 N/A GLU 29.A N GLU 25.A O no hydrogen 2.900 N/A MET 30.A N MET 27.A O no hydrogen 3.125 N/A LYS 31.A N MET 28.A O no hydrogen 3.055 N/A TYR 32.A N MET 27.A O no hydrogen 2.993 N/A ASN 33.A N PRO 82.A O no hydrogen 3.232 N/A ASN 33.A ND2 HIS 83.A O no hydrogen 2.981 N/A LYS 35.A NZ ASP 84.A OD2 no hydrogen 3.178 N/A LYS 36.A N ASN 33.A OD1 no hydrogen 2.690 N/A ALA 37.A N ASN 33.A O no hydrogen 3.172 N/A LYS 41.A N PRO 38.A O no hydrogen 3.066 N/A LEU 42.A N LEU 39.A O no hydrogen 3.168 N/A THR 43.A OG1 GLN 46.A OE1 no hydrogen 2.428 N/A GLN 46.A NE2 LYS 41.A O no hydrogen 3.522 N/A ILE 47.A N THR 43.A O no hydrogen 3.453 N/A LYS 48.A N VAL 44.A O no hydrogen 2.898 N/A ALA 49.A N ALA 45.A O no hydrogen 2.918 N/A GLY 50.A N GLN 46.A O no hydrogen 3.148 N/A TYR 51.A N ILE 47.A O no hydrogen 2.996 N/A GLN 52.A N LYS 48.A O no hydrogen 3.174 N/A SER 53.A N ALA 49.A O no hydrogen 3.224 N/A SER 53.A OG GLU 76.A OE2 no hydrogen 2.646 N/A LEU 54.A N GLY 50.A O no hydrogen 2.991 N/A LYS 55.A N TYR 51.A O no hydrogen 3.068 N/A LYS 56.A N GLN 52.A O no hydrogen 3.386 N/A LYS 56.A NZ GLU 76.A OE2 no hydrogen 3.424 N/A ILE 57.A N SER 53.A O no hydrogen 3.254 N/A GLU 58.A N LEU 54.A O no hydrogen 2.903 N/A ASP 59.A N LYS 55.A O no hydrogen 2.992 N/A CYS 60.A N LYS 56.A O no hydrogen 3.214 N/A CYS 60.A SG LYS 56.A O no hydrogen 3.714 N/A ILE 61.A N ILE 57.A O no hydrogen 3.011 N/A ARG 62.A N GLU 58.A O no hydrogen 3.014 N/A ALA 63.A N ASP 59.A O no hydrogen 2.937 N/A GLY 64.A N ILE 61.A O no hydrogen 3.294 N/A GLN 65.A N CYS 60.A O no hydrogen 2.822 N/A GLN 65.A NE2 ALA 63.A O no hydrogen 2.959 N/A ARG 68.A NH1 GLU 72.A OE2 no hydrogen 2.952 N/A LEU 70.A N GLY 67.A O no hydrogen 3.056 N/A MET 71.A N GLY 67.A O no hydrogen 3.213 N/A GLU 72.A N ARG 68.A O no hydrogen 2.958 N/A ALA 73.A N ALA 69.A O no hydrogen 3.315 N/A CYS 74.A N LEU 70.A O no hydrogen 2.915 N/A CYS 74.A SG LEU 70.A O no hydrogen 3.390 N/A ASN 75.A N MET 71.A O no hydrogen 3.094 N/A GLU 76.A N GLU 72.A O no hydrogen 2.934 N/A PHE 77.A N ALA 73.A O no hydrogen 3.209 N/A TYR 78.A N CYS 74.A O no hydrogen 2.848 N/A TYR 78.A OH PRO 91.A O no hydrogen 3.134 N/A THR 79.A N GLU 76.A O no hydrogen 3.335 N/A THR 79.A OG1 ASN 75.A O no hydrogen 2.793 N/A THR 79.A OG1 ASN 75.A OD1 no hydrogen 3.464 N/A ARG 80.A N GLU 76.A O no hydrogen 3.058 N/A ARG 80.A NH1 ALA 49.A O no hydrogen 2.602 N/A ILE 81.A N PHE 77.A O no hydrogen 2.849 N/A HIS 83.A ND1 ILE 81.A O no hydrogen 2.884 N/A GLY 86.A N ASP 84.A OD1 no hydrogen 3.227 N/A ARG 88.A N PHE 85.A O no hydrogen 3.261 N/A ARG 94.A N GLU 98.A OE1 no hydrogen 2.858 N/A GLU 98.A N THR 95.A OG1 no hydrogen 3.035 N/A LEU 99.A N THR 95.A O no hydrogen 2.953 N/A SER 100.A N GLN 96.A O no hydrogen 2.762 N/A GLU 101.A N LYS 97.A O no hydrogen 3.065 N/A LYS 102.A N GLU 98.A O no hydrogen 3.402 N/A LYS 102.A N LEU 99.A O no hydrogen 3.151 N/A ILE 103.A N LEU 99.A O no hydrogen 3.076 N/A GLN 104.A N SER 100.A O no hydrogen 3.078 N/A GLN 104.A NE2 SER 100.A O no hydrogen 3.338 N/A GLN 104.A NE2 SER 100.A OG no hydrogen 3.258 N/A LEU 105.A N GLU 101.A O no hydrogen 3.283 N/A LEU 106.A N LYS 102.A O no hydrogen 3.219 N/A GLU 107.A N ILE 103.A O no hydrogen 2.827 N/A ALA 108.A N GLN 104.A O no hydrogen 3.006 N/A LEU 109.A N LEU 105.A O no hydrogen 2.919 N/A GLY 110.A N LEU 106.A O no hydrogen 3.053 N/A ASP 111.A N GLU 107.A O no hydrogen 3.369 N/A ILE 112.A N ALA 108.A O no hydrogen 2.922 N/A GLU 113.A N LEU 109.A O no hydrogen 2.879 N/A ILE 114.A N GLY 110.A O no hydrogen 3.282 N/A ALA 115.A N ASP 111.A O no hydrogen 3.132 N/A ILE 116.A N ILE 112.A O no hydrogen 2.733 N/A LYS 117.A N GLU 113.A O no hydrogen 3.133 N/A LYS 117.A NZ GLU 113.A OE2 no hydrogen 2.886 N/A LEU 118.A N ALA 115.A O no hydrogen 3.055 N/A VAL 119.A N ALA 115.A O no hydrogen 3.064 N/A LYS 120.A N ILE 116.A O no hydrogen 3.242 N/A SER 121.A OG LEU 118.A O no hydrogen 2.752 N/A GLN 124.A NE2 SER 121.A O no hydrogen 2.752 N/A LEU 130.A N HIS 128.A ND1 no hydrogen 3.006 N/A GLN 132.A N HIS 128.A O no hydrogen 2.853 N/A GLN 132.A NE2 GLN 124.A OE1 no hydrogen 2.916 N/A HIS 133.A N PRO 129.A O no hydrogen 3.116 N/A TYR 134.A N LEU 130.A O no hydrogen 3.065 N/A ARG 135.A N ASP 131.A O no hydrogen 2.933 N/A ASN 136.A N GLN 132.A O no hydrogen 3.184 N/A LEU 137.A N HIS 133.A O no hydrogen 3.181 N/A LEU 137.A N TYR 134.A O no hydrogen 3.284 N/A HIS 138.A N ARG 135.A O no hydrogen 3.232 N/A CYS 139.A SG ALA 140.A O no hydrogen 3.649 N/A ALA 140.A N GLU 180.A O no hydrogen 2.982 N/A LEU 141.A N TYR 134.A OH no hydrogen 2.936 N/A ARG 142.A N GLU 178.A O no hydrogen 3.071 N/A ARG 142.A NH2 GLU 180.A OE2 no hydrogen 3.237 N/A LEU 144.A N LEU 176.A O no hydrogen 2.990 N/A HIS 146.A NE2 LEU 174.A O no hydrogen 3.057 N/A GLU 147.A N ASP 145.A OD1 no hydrogen 3.207 N/A SER 148.A N ASP 145.A O no hydrogen 3.114 N/A SER 148.A OG ASP 145.A O no hydrogen 2.822 N/A PHE 151.A N SER 148.A OG no hydrogen 3.383 N/A LYS 152.A N SER 148.A O no hydrogen 3.453 N/A VAL 153.A N TYR 149.A O no hydrogen 3.131 N/A ILE 154.A N GLU 150.A O no hydrogen 2.906 N/A SER 155.A N PHE 151.A O no hydrogen 2.974 N/A GLN 156.A N LYS 152.A O no hydrogen 2.989 N/A TYR 157.A N VAL 153.A O no hydrogen 2.701 N/A TYR 157.A OH LEU 197.A O no hydrogen 2.609 N/A LEU 158.A N ILE 154.A O no hydrogen 2.710 N/A GLN 159.A N SER 155.A O no hydrogen 3.005 N/A GLN 159.A NE2 MET 171.A O no hydrogen 2.739 N/A SER 160.A N GLN 156.A O no hydrogen 2.843 N/A SER 160.A OG GLN 156.A O no hydrogen 2.493 N/A THR 161.A OG1 TYR 157.A O no hydrogen 2.226 N/A HIS 162.A N GLN 159.A O no hydrogen 3.085 N/A HIS 162.A NE2 HIS 166.A O no hydrogen 3.277 N/A ALA 163.A N SER 240.A OG no hydrogen 3.170 N/A THR 165.A OG1 TYR 328.A OH no hydrogen 2.414 N/A HIS 166.A ND1 SER 240.A OG no hydrogen 2.371 N/A TYR 169.A OH ASN 244.A OD1 no hydrogen 2.527 N/A THR 170.A N ASN 350.A O no hydrogen 3.055 N/A THR 172.A N GLN 348.A O no hydrogen 3.012 N/A THR 172.A OG1 ASN 350.A OD1 no hydrogen 2.714 N/A LEU 174.A N LYS 346.A O no hydrogen 2.739 N/A ASP 175.A N LYS 346.A O no hydrogen 3.366 N/A LEU 176.A N ASP 175.A OD1 no hydrogen 3.221 N/A PHE 177.A N LEU 344.A O no hydrogen 2.847 N/A GLU 178.A N ARG 142.A O no hydrogen 2.751 N/A VAL 179.A N ARG 342.A O no hydrogen 2.578 N/A GLU 180.A N ALA 140.A O no hydrogen 3.225 N/A ASP 182.A N HIS 138.A O no hydrogen 3.015 N/A GLU 184.A N LYS 181.A O no hydrogen 3.193 N/A GLU 186.A N GLU 186.A OE1 no hydrogen 2.644 N/A ARG 189.A N ASN 337.A O no hydrogen 3.092 N/A ARG 189.A NE ASP 191.A OD2 no hydrogen 3.380 N/A GLU 190.A N PHE 188.A O no hydrogen 2.936 N/A LEU 192.A N ARG 189.A O no hydrogen 3.364 N/A ASN 194.A ND2 GLY 265.A O no hydrogen 2.546 N/A MET 196.A N VAL 262.A O no hydrogen 3.283 N/A LEU 197.A N THR 307.A O no hydrogen 3.024 N/A LEU 198.A N SER 260.A O no hydrogen 3.234 N/A TRP 199.A N ALA 236.A O no hydrogen 2.964 N/A HIS 200.A ND1 TYR 234.A O no hydrogen 2.932 N/A SER 205.A OG ASN 206.A OD1 no hydrogen 3.434 N/A ASN 206.A N ARG 203.A O no hydrogen 3.295 N/A ASN 206.A ND2 SER 202.A OG no hydrogen 2.781 N/A ILE 210.A N ASN 206.A O no hydrogen 2.853 N/A LEU 211.A N TRP 207.A O no hydrogen 2.746 N/A SER 212.A N VAL 208.A O no hydrogen 3.190 N/A SER 212.A OG VAL 208.A O no hydrogen 3.106 N/A SER 212.A OG HIS 213.A ND1 no hydrogen 2.675 N/A HIS 213.A N GLY 209.A O no hydrogen 2.953 N/A HIS 213.A ND1 SER 212.A OG no hydrogen 2.675 N/A GLY 214.A N ILE 210.A O no hydrogen 2.838 N/A ARG 216.A NE GLY 214.A O no hydrogen 2.674 N/A ARG 216.A NH1 ASP 111.A OD1 no hydrogen 3.324 N/A ARG 216.A NH2 ASP 111.A OD1 no hydrogen 3.243 N/A ARG 216.A NH2 GLY 214.A O no hydrogen 3.285 N/A GLU 221.A N GLU 221.A OE1 no hydrogen 2.891 N/A ALA 222.A N PRO 219.A O no hydrogen 3.171 N/A THR 225.A OG1 GLU 58.A OE2 no hydrogen 2.913 N/A TYR 227.A N ILE 224.A O no hydrogen 3.380 N/A PHE 229.A N TYR 234.A OH no hydrogen 2.818 N/A GLY 230.A N TYR 227.A O no hydrogen 3.512 N/A LYS 231.A NZ PRO 219.A O no hydrogen 3.146 N/A LYS 231.A NZ ALA 222.A O no hydrogen 2.715 N/A ILE 233.A N VAL 333.A O no hydrogen 2.887 N/A TYR 234.A OH GLY 230.A O no hydrogen 2.601 N/A PHE 235.A N TYR 331.A O no hydrogen 2.595 N/A ALA 236.A N TRP 199.A O no hydrogen 3.419 N/A SER 239.A N THR 161.A O no hydrogen 3.249 N/A SER 239.A OG LEU 158.A O no hydrogen 2.779 N/A SER 240.A OG HIS 166.A ND1 no hydrogen 2.371 N/A LYS 241.A NZ TYR 328.A O no hydrogen 3.232 N/A LYS 241.A NZ ASN 329.A O no hydrogen 3.218 N/A ALA 243.A N SER 239.A O no hydrogen 2.944 N/A ASN 244.A N SER 240.A O no hydrogen 3.113 N/A TYR 245.A N SER 242.A O no hydrogen 3.048 N/A CYS 246.A N ALA 243.A O no hydrogen 3.137 N/A CYS 246.A SG SER 202.A O no hydrogen 3.854 N/A CYS 246.A SG LEU 256.A O no hydrogen 3.173 N/A PHE 247.A N ASN 244.A O no hydrogen 3.215 N/A SER 249.A N LYS 252.A O no hydrogen 2.808 N/A SER 249.A OG LYS 252.A O no hydrogen 3.317 N/A LYS 252.A N SER 249.A OG no hydrogen 2.897 N/A ASN 253.A ND2 PHE 349.A O no hydrogen 3.112 N/A GLY 255.A N VAL 347.A O no hydrogen 3.003 N/A LEU 257.A N LEU 345.A O no hydrogen 2.993 N/A LEU 258.A N HIS 200.A O no hydrogen 2.986 N/A LEU 259.A N TYR 343.A O no hydrogen 2.897 N/A SER 260.A N LEU 198.A O no hydrogen 3.253 N/A GLU 261.A N ARG 340.A O no hydrogen 2.724 N/A VAL 262.A N MET 196.A O no hydrogen 3.016 N/A ALA 263.A N GLN 338.A O no hydrogen 2.764 N/A LEU 264.A N ASN 194.A O no hydrogen 3.174 N/A GLY 265.A N HIS 193.A O no hydrogen 2.854 N/A GLN 266.A N HIS 285.A ND1 no hydrogen 3.048 N/A CYS 267.A SG SER 286.A OG no hydrogen 3.435 N/A ASN 268.A N SER 286.A O no hydrogen 2.732 N/A LEU 270.A N LYS 288.A O no hydrogen 2.865 N/A ASN 274.A N MET 228.A O no hydrogen 2.927 N/A LEU 280.A N ALA 277.A O no hydrogen 3.240 N/A LEU 281.A N GLU 278.A O no hydrogen 3.508 N/A LYS 284.A N LEU 281.A O no hydrogen 3.470 N/A LYS 284.A NZ ASN 268.A OD1 no hydrogen 3.468 N/A HIS 285.A N GLN 266.A O no hydrogen 3.332 N/A SER 286.A OG LEU 264.A O no hydrogen 2.928 N/A THR 287.A N ILE 332.A O no hydrogen 3.105 N/A THR 287.A OG1 TYR 334.A OH no hydrogen 3.278 N/A LYS 288.A N ASN 268.A O no hydrogen 2.782 N/A GLY 289.A N GLU 330.A O no hydrogen 2.685 N/A LEU 290.A N LEU 270.A O no hydrogen 2.854 N/A GLY 291.A N ASN 329.A OD1 no hydrogen 2.735 N/A LYS 292.A N LEU 326.A O no hydrogen 2.823 N/A MET 293.A N ASN 327.A O no hydrogen 2.976 N/A ALA 294.A N SER 314.A O no hydrogen 3.233 N/A HIS 299.A N SER 296.A O no hydrogen 3.309 N/A VAL 301.A N VAL 308.A O no hydrogen 3.457 N/A LEU 303.A N SER 306.A O no hydrogen 2.763 N/A SER 306.A OG ASN 304.A O no hydrogen 3.262 N/A THR 307.A N ARG 195.A O no hydrogen 2.838 N/A VAL 308.A N VAL 301.A O no hydrogen 2.861 N/A LEU 310.A N VAL 308.A O no hydrogen 2.966 N/A GLY 311.A N SER 160.A OG no hydrogen 2.875 N/A SER 314.A N ALA 294.A O no hydrogen 3.131 N/A THR 316.A N LYS 292.A O no hydrogen 3.047 N/A THR 316.A OG1 GLY 291.A O no hydrogen 2.752 N/A THR 316.A OG1 LYS 292.A O no hydrogen 3.191 N/A ASN 320.A N THR 325.A OG1 no hydrogen 2.960 N/A ASN 320.A ND2 TYR 324.A O no hydrogen 2.816 N/A TYR 328.A OH THR 165.A OG1 no hydrogen 2.414 N/A ASN 329.A ND2 ASP 237.A OD2 no hydrogen 3.222 N/A GLU 330.A N GLY 289.A O no hydrogen 3.024 N/A TYR 331.A N PHE 235.A O no hydrogen 3.012 N/A ILE 332.A N THR 287.A O no hydrogen 2.961 N/A VAL 333.A N ILE 233.A O no hydrogen 3.184 N/A TYR 334.A OH PHE 229.A O no hydrogen 2.586 N/A TYR 334.A OH THR 287.A OG1 no hydrogen 3.278 N/A ASN 337.A N ASN 335.A OD1 no hydrogen 3.529 N/A ASN 337.A ND2 ALA 187.A O no hydrogen 3.684 N/A GLN 338.A N ASN 335.A O no hydrogen 3.104 N/A GLN 338.A NE2 ALA 263.A O no hydrogen 2.843 N/A GLN 338.A NE2 HIS 285.A O no hydrogen 3.021 N/A VAL 339.A N PRO 336.A O no hydrogen 3.123 N/A ARG 340.A N GLU 261.A O no hydrogen 3.017 N/A ARG 340.A NH1 GLU 261.A OE1 no hydrogen 3.544 N/A MET 341.A N GLU 184.A OE1 no hydrogen 3.040 N/A ARG 342.A N LEU 259.A O no hydrogen 2.947 N/A ARG 342.A NE GLU 261.A OE2 no hydrogen 2.720 N/A TYR 343.A N LEU 259.A O no hydrogen 2.981 N/A TYR 343.A OH GLU 150.A OE2 no hydrogen 2.853 N/A LEU 344.A N PHE 177.A O no hydrogen 2.925 N/A LEU 345.A N LEU 257.A O no hydrogen 2.729 N/A LYS 346.A N ASP 175.A O no hydrogen 2.830 N/A VAL 347.A N GLY 255.A O no hydrogen 3.135 N/A GLN 348.A N THR 172.A O no hydrogen 2.904 N/A PHE 349.A N ASN 253.A O no hydrogen 2.772 N/A ASN 350.A N THR 170.A O no hydrogen 2.812 N/A ASN 350.A ND2 GLN 348.A OE1 no hydrogen 2.581 N/A LEU 352.A N ASP 168.A O no hydrogen 2.861 N/A