Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8hxi_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): GLN 6.A N PRO 3.A O no hydrogen 2.687 N/A LEU 7.A N LEU 4.A O no hydrogen 3.195 N/A ARG 8.A NH1 TYR 10.A OH no hydrogen 2.521 N/A SER 15.A N ASP 13.A OD1 no hydrogen 3.021 N/A SER 15.A OG ASP 13.A OD1 no hydrogen 3.298 N/A TRP 16.A N ASP 13.A O no hydrogen 2.966 N/A LEU 17.A N ASP 36.A OD2 no hydrogen 2.830 N/A GLN 18.A NE2 ALA 14.A O no hydrogen 3.404 N/A LEU 23.A N GLN 31.A O no hydrogen 2.943 N/A GLN 24.A NE2 ALA 26.A O no hydrogen 2.736 N/A GLN 24.A NE2 ASP 27.A O no hydrogen 3.286 N/A ILE 25.A N THR 29.A O no hydrogen 2.752 N/A ALA 26.A N THR 29.A O no hydrogen 3.113 N/A ASP 27.A N THR 171.A O no hydrogen 2.992 N/A HIS 28.A N ASP 170.A OD2 no hydrogen 2.928 N/A HIS 28.A ND1 ASP 170.A OD1 no hydrogen 2.966 N/A THR 29.A N ALA 26.A O no hydrogen 3.506 N/A THR 29.A OG1 ASP 170.A OD2 no hydrogen 2.810 N/A TRP 30.A N LEU 41.A O no hydrogen 2.850 N/A GLN 31.A N LEU 23.A O no hydrogen 2.858 N/A GLN 31.A NE2 LEU 37.A O no hydrogen 3.243 N/A ILE 32.A N ALA 39.A O no hydrogen 2.835 N/A THR 34.A N LEU 37.A O no hydrogen 3.148 N/A THR 34.A OG1 ASP 36.A OD1 no hydrogen 2.661 N/A GLU 35.A N GLN 18.A O no hydrogen 2.876 N/A THR 38.A N PRO 223.A O no hydrogen 2.899 N/A THR 38.A OG1 THR 222.A O no hydrogen 2.671 N/A THR 38.A OG1 PRO 223.A O no hydrogen 3.329 N/A THR 38.A OG1 TYR 232.A OH no hydrogen 2.512 N/A ALA 39.A N GLN 31.A OE1 no hydrogen 2.961 N/A LEU 40.A N LEU 51.A O no hydrogen 2.918 N/A LEU 41.A N TRP 30.A O no hydrogen 2.763 N/A VAL 42.A N VAL 49.A O no hydrogen 2.730 N/A GLN 43.A N HIS 28.A O no hydrogen 2.923 N/A GLN 43.A NE2 ARG 69.A O no hydrogen 2.824 N/A THR 44.A N GLY 47.A O no hydrogen 3.162 N/A THR 44.A OG1 GLY 47.A O no hydrogen 2.579 N/A ASP 46.A N THR 44.A OG1 no hydrogen 3.062 N/A GLY 47.A N THR 44.A O no hydrogen 3.232 N/A ALA 48.A N ASP 75.A O no hydrogen 2.983 N/A VAL 49.A N VAL 42.A O no hydrogen 2.762 N/A LEU 50.A N LEU 78.A O no hydrogen 2.808 N/A LEU 51.A N LEU 40.A O no hydrogen 2.791 N/A ASP 52.A N LEU 80.A O no hydrogen 2.911 N/A GLY 53.A N HIS 88.A O no hydrogen 2.898 N/A GLY 54.A N HIS 88.A O no hydrogen 3.145 N/A GLN 57.A N GLN 57.A OE1 no hydrogen 2.844 N/A MET 58.A N MET 55.A O no hydrogen 2.911 N/A HIS 61.A NE2 GLY 33.A O no hydrogen 2.760 N/A LEU 62.A N MET 58.A O no hydrogen 2.970 N/A LEU 63.A N ALA 59.A O no hydrogen 3.052 N/A ASP 64.A N SER 60.A O no hydrogen 2.987 N/A ASN 65.A N HIS 61.A O no hydrogen 2.978 N/A ASN 65.A ND2 MET 20.A O no hydrogen 2.958 N/A ASN 65.A ND2 ILE 32.A O no hydrogen 2.869 N/A MET 66.A N LEU 62.A O no hydrogen 2.815 N/A LYS 67.A N LEU 63.A O no hydrogen 2.905 N/A ALA 68.A N ASP 64.A O no hydrogen 2.969 N/A ARG 69.A N ASN 65.A O no hydrogen 3.168 N/A ARG 69.A NE GLN 43.A OE1 no hydrogen 3.191 N/A ARG 69.A NH2 GLN 43.A OE1 no hydrogen 3.517 N/A GLY 70.A N LYS 67.A O no hydrogen 2.766 N/A VAL 71.A N MET 66.A O no hydrogen 2.818 N/A THR 72.A N ASP 75.A OD2 no hydrogen 2.872 N/A ASP 75.A N THR 72.A O no hydrogen 2.812 N/A ARG 77.A N ALA 48.A O no hydrogen 2.947 N/A ARG 77.A NH1 ASP 46.A O no hydrogen 2.804 N/A ILE 79.A N LYS 102.A O no hydrogen 2.810 N/A LEU 80.A N LEU 50.A O no hydrogen 2.927 N/A SER 82.A N ASP 52.A OD1 no hydrogen 2.933 N/A SER 82.A OG ASP 52.A OD1 no hydrogen 3.370 N/A SER 82.A OG ASP 52.A OD2 no hydrogen 2.748 N/A SER 82.A OG ASP 183.A OD1 no hydrogen 3.363 N/A HIS 83.A N SER 82.A OG no hydrogen 2.807 N/A HIS 83.A ND1 ASP 183.A OD1 no hydrogen 2.671 N/A HIS 85.A NE2 ASP 120.A OD1 no hydrogen 2.889 N/A ASP 87.A N ASP 87.A OD1 no hydrogen 2.609 N/A HIS 88.A N HIS 85.A O no hydrogen 3.012 N/A HIS 88.A NE2 HIS 224.A NE2 no hydrogen 3.065 N/A ALA 89.A N HIS 85.A O no hydrogen 2.850 N/A GLY 90.A N GLY 54.A O no hydrogen 2.922 N/A VAL 92.A N ALA 89.A O no hydrogen 3.140 N/A LEU 95.A N PRO 91.A O no hydrogen 2.820 N/A LYS 96.A N VAL 92.A O no hydrogen 2.831 N/A LYS 96.A NZ ASN 133.A O no hydrogen 2.764 N/A LYS 96.A NZ ASP 135.A OD2 no hydrogen 2.832 N/A ARG 97.A N ALA 93.A O no hydrogen 3.109 N/A ARG 98.A N GLU 94.A O no hydrogen 3.035 N/A ARG 98.A N LEU 95.A O no hydrogen 3.163 N/A ARG 98.A NH1 SER 60.A OG no hydrogen 3.005 N/A ARG 98.A NH1 GLU 94.A OE2 no hydrogen 2.892 N/A THR 99.A OG1 LEU 95.A O no hydrogen 2.900 N/A GLY 100.A N PRO 73.A O no hydrogen 3.077 N/A ALA 101.A N THR 99.A OG1 no hydrogen 2.910 N/A LYS 102.A N ARG 77.A O no hydrogen 3.047 N/A VAL 103.A N ASP 135.A OD2 no hydrogen 2.805 N/A ALA 104.A N ILE 79.A O no hydrogen 3.149 N/A ALA 105.A N ARG 136.A O no hydrogen 3.067 N/A ASN 106.A ND2 GLY 162.A O no hydrogen 3.051 N/A SER 109.A N ASN 106.A OD1 no hydrogen 2.874 N/A SER 109.A OG ASN 106.A OD1 no hydrogen 3.108 N/A SER 109.A OG GLY 162.A O no hydrogen 2.984 N/A ALA 110.A N ASN 106.A O no hydrogen 2.772 N/A VAL 111.A N ALA 107.A O no hydrogen 2.955 N/A LEU 112.A N GLU 108.A O no hydrogen 3.148 N/A LEU 113.A N SER 109.A O no hydrogen 2.804 N/A ALA 114.A N ALA 110.A O no hydrogen 2.883 N/A ARG 115.A N VAL 111.A O no hydrogen 3.243 N/A ARG 115.A N LEU 112.A O no hydrogen 3.273 N/A ARG 115.A NE SER 118.A O no hydrogen 2.745 N/A ARG 115.A NH2 ASP 119.A O no hydrogen 2.792 N/A GLY 116.A N LEU 113.A O no hydrogen 2.948 N/A GLY 117.A N LEU 112.A O no hydrogen 2.961 N/A SER 118.A N ARG 115.A O no hydrogen 3.048 N/A SER 118.A OG ARG 115.A O no hydrogen 2.721 N/A ASP 119.A N ASP 125.A OD1 no hydrogen 2.864 N/A ASP 120.A N GLY 124.A O no hydrogen 2.957 N/A HIS 122.A N ASP 120.A OD2 no hydrogen 2.895 N/A PHE 123.A N ASP 120.A OD2 no hydrogen 2.932 N/A GLY 126.A N PHE 123.A O no hydrogen 3.158 N/A THR 128.A OG1 ASP 125.A O no hydrogen 3.412 N/A TYR 129.A N GLY 116.A O no hydrogen 2.768 N/A TYR 129.A OH ALA 84.A O no hydrogen 2.778 N/A ALA 132.A N LEU 113.A O no hydrogen 3.141 N/A ASP 135.A N VAL 103.A O no hydrogen 2.766 N/A ARG 136.A N VAL 103.A O no hydrogen 3.069 N/A ARG 136.A NH2 GLU 142.A OE2 no hydrogen 2.814 N/A VAL 138.A N ALA 105.A O no hydrogen 2.998 N/A MET 139.A N GLU 142.A OE1 no hydrogen 2.890 N/A GLY 141.A N ALA 153.A O no hydrogen 2.862 N/A GLU 142.A N MET 139.A O no hydrogen 3.058 N/A ILE 144.A N PHE 151.A O no hydrogen 2.834 N/A VAL 146.A N ILE 149.A O no hydrogen 2.924 N/A ILE 149.A N VAL 146.A O no hydrogen 2.848 N/A PHE 151.A N ILE 144.A O no hydrogen 2.860 N/A THR 152.A N THR 167.A O no hydrogen 2.949 N/A ALA 153.A N GLU 142.A O no hydrogen 3.120 N/A HIS 154.A N ALA 165.A O no hydrogen 2.729 N/A HIS 154.A NE2 THR 167.A OG1 no hydrogen 2.718 N/A PHE 155.A N ASP 140.A OD1 no hydrogen 2.916 N/A MET 156.A N SER 163.A O no hydrogen 2.857 N/A GLY 158.A N THR 160.A O no hydrogen 3.032 N/A HIS 159.A ND1 SER 186.A O no hydrogen 2.958 N/A THR 160.A N SER 163.A OG no hydrogen 3.052 N/A THR 160.A OG1 SER 163.A OG no hydrogen 3.034 N/A SER 163.A N THR 160.A O no hydrogen 3.120 N/A SER 163.A OG THR 160.A O no hydrogen 3.301 N/A SER 163.A OG THR 160.A OG1 no hydrogen 3.034 N/A SER 163.A OG ASP 183.A OD2 no hydrogen 2.524 N/A THR 164.A N SER 82.A O no hydrogen 2.943 N/A THR 164.A OG1 GLY 162.A O no hydrogen 2.977 N/A ALA 165.A N HIS 154.A O no hydrogen 2.788 N/A TRP 166.A N TYR 181.A O no hydrogen 3.004 N/A TRP 166.A NE1 LEU 81.A O no hydrogen 3.040 N/A THR 167.A N THR 152.A O no hydrogen 3.088 N/A THR 167.A OG1 HIS 154.A NE2 no hydrogen 2.718 N/A TRP 168.A N ILE 179.A O no hydrogen 2.989 N/A TRP 168.A NE1 THR 29.A OG1 no hydrogen 3.267 N/A ASP 170.A N VAL 177.A O no hydrogen 2.900 N/A THR 171.A N ASP 170.A OD1 no hydrogen 2.766 N/A THR 171.A OG1 ASP 27.A OD2 no hydrogen 2.894 N/A ARG 172.A N LYS 175.A O no hydrogen 2.926 N/A ARG 172.A NH1 ILE 25.A O no hydrogen 3.520 N/A LYS 175.A N ASN 173.A O no hydrogen 2.825 N/A VAL 177.A N ASP 170.A O no hydrogen 2.760 N/A ARG 178.A N ASP 218.A OD2 no hydrogen 2.818 N/A ARG 178.A NE ASP 218.A OD2 no hydrogen 3.001 N/A ARG 178.A NH2 ASP 218.A OD1 no hydrogen 2.934 N/A ILE 179.A N TRP 168.A O no hydrogen 2.797 N/A ALA 180.A N VAL 219.A O no hydrogen 2.894 N/A TYR 181.A N TRP 166.A O no hydrogen 2.849 N/A TYR 181.A OH ASP 52.A OD2 no hydrogen 2.665 N/A ALA 182.A N LEU 221.A O no hydrogen 3.007 N/A SER 186.A OG HIS 159.A ND1 no hydrogen 2.999 N/A TYR 190.A N ALA 187.A O no hydrogen 3.175 N/A TYR 190.A OH HIS 159.A O no hydrogen 2.737 N/A GLN 191.A NE2 GLN 193.A O no hydrogen 2.975 N/A LEU 192.A N GLU 263.A OE2 no hydrogen 3.000 N/A GLN 193.A N GLU 263.A OE1 no hydrogen 2.840 N/A ASN 195.A ND2 GLN 191.A O no hydrogen 2.783 N/A ARG 197.A N ASN 195.A OD1 no hydrogen 3.045 N/A ARG 197.A NH1 ASP 119.A OD1 no hydrogen 3.294 N/A ARG 197.A NH2 ASP 119.A O no hydrogen 3.423 N/A ARG 197.A NH2 ASP 119.A OD1 no hydrogen 3.255 N/A ARG 197.A NH2 ASP 119.A OD2 no hydrogen 3.527 N/A TYR 198.A N ASN 195.A O no hydrogen 3.037 N/A TYR 198.A OH ASP 204.A OD2 no hydrogen 2.714 N/A LEU 201.A N TYR 198.A O no hydrogen 3.253 N/A ASP 204.A N HIS 200.A O no hydrogen 2.917 N/A TYR 205.A N LEU 201.A O no hydrogen 2.921 N/A TYR 205.A OH SER 186.A O no hydrogen 2.669 N/A ARG 206.A N ILE 202.A O no hydrogen 3.002 N/A ARG 206.A NH1 GLU 253.A OE2 no hydrogen 3.178 N/A ARG 206.A NH1 ASP 257.A OD1 no hydrogen 2.924 N/A ARG 206.A NH2 ASP 257.A OD1 no hydrogen 3.050 N/A ARG 207.A N GLU 203.A O no hydrogen 3.111 N/A ARG 207.A NH1 GLU 203.A OE1 no hydrogen 3.334 N/A ARG 207.A NH2 ASP 204.A OD1 no hydrogen 2.456 N/A SER 208.A N ASP 204.A O no hydrogen 2.966 N/A SER 208.A OG ALA 157.A O no hydrogen 2.612 N/A SER 208.A OG ASP 204.A O no hydrogen 3.022 N/A PHE 209.A N TYR 205.A O no hydrogen 2.902 N/A ALA 210.A N ARG 206.A O no hydrogen 3.380 N/A THR 211.A N ARG 207.A O no hydrogen 2.855 N/A THR 211.A OG1 ARG 207.A O no hydrogen 3.028 N/A VAL 212.A N SER 208.A O no hydrogen 2.863 N/A ARG 213.A N PHE 209.A O no hydrogen 3.039 N/A ARG 213.A NE ASP 250.A OD1 no hydrogen 2.953 N/A ARG 213.A NH2 ASP 250.A OD1 no hydrogen 3.277 N/A ARG 213.A NH2 GLU 253.A OE1 no hydrogen 2.742 N/A ALA 214.A N ALA 210.A O no hydrogen 3.273 N/A LEU 215.A N VAL 212.A O no hydrogen 3.047 N/A ASP 218.A N ARG 178.A O no hydrogen 2.764 N/A VAL 219.A N ARG 178.A O no hydrogen 3.005 N/A LEU 221.A N ALA 180.A O no hydrogen 2.947 N/A THR 222.A OG1 HIS 224.A O no hydrogen 2.713 N/A THR 222.A OG1 SER 228.A OG no hydrogen 2.848 N/A ALA 227.A N HIS 224.A O no hydrogen 2.946 N/A SER 228.A N PRO 225.A O no hydrogen 3.142 N/A SER 228.A OG THR 222.A OG1 no hydrogen 2.848 N/A SER 228.A OG PRO 225.A O no hydrogen 3.462 N/A ASN 229.A N GLY 226.A O no hydrogen 3.052 N/A TRP 230.A N PRO 225.A O no hydrogen 2.987 N/A TRP 230.A NE1 LEU 220.A O no hydrogen 2.746 N/A ASP 231.A N ALA 238.A O no hydrogen 3.037 N/A TYR 232.A OH THR 38.A OG1 no hydrogen 2.512 N/A ALA 234.A N ASP 231.A O no hydrogen 3.118 N/A ARG 237.A N ALA 234.A O no hydrogen 2.891 N/A ALA 238.A N GLY 235.A O no hydrogen 2.907 N/A ALA 240.A N ARG 237.A O no hydrogen 2.843 N/A ALA 242.A N GLY 239.A O no hydrogen 3.137 N/A LEU 243.A N SER 228.A O no hydrogen 2.874 N/A ALA 247.A N THR 244.A OG1 no hydrogen 2.987 N/A TYR 248.A N THR 244.A O no hydrogen 2.967 N/A TYR 248.A OH ASP 183.A O no hydrogen 2.695 N/A ALA 249.A N CYS 245.A O no hydrogen 2.925 N/A ASP 250.A N LYS 246.A O no hydrogen 2.791 N/A ALA 251.A N ALA 247.A O no hydrogen 2.901 N/A ALA 252.A N TYR 248.A O no hydrogen 3.039 N/A GLU 253.A N ALA 249.A O no hydrogen 2.876 N/A GLN 254.A N ASP 250.A O no hydrogen 3.001 N/A LYS 255.A N ALA 251.A O no hydrogen 3.031 N/A PHE 256.A N ALA 252.A O no hydrogen 2.919 N/A ASP 257.A N GLU 253.A O no hydrogen 2.862 N/A GLY 258.A N GLN 254.A O no hydrogen 3.038 N/A GLN 259.A N LYS 255.A O no hydrogen 2.946 N/A LEU 260.A N PHE 256.A O no hydrogen 2.911 N/A ALA 261.A N ASP 257.A O no hydrogen 2.940 N/A LYS 262.A N GLY 258.A O no hydrogen 3.085 N/A GLU 263.A N GLN 259.A O no hydrogen 2.925 N/A THR 264.A N LEU 260.A O no hydrogen 3.103 N/A THR 264.A OG1 GLN 193.A OE1 no hydrogen 3.544 N/A