Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8i12_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): TYR 3.A OH GLN 414.A OE1.A no hydrogen 2.531 N/A ARG 4.A N ASP 1.A O no hydrogen 3.283 N/A ARG 4.A NE ASP 1.A OD2 no hydrogen 2.865 N/A ARG 4.A NH1 THR 10.A OG1 no hydrogen 2.846 N/A ARG 4.A NH1 ALA 11.A O no hydrogen 2.808 N/A ARG 4.A NH2 ASP 1.A OD2 no hydrogen 3.324 N/A ARG 4.A NH2 GLU 12.A O no hydrogen 2.888 N/A ALA 6.A N ASP 443.A OD1 no hydrogen 2.783 N/A PHE 7.A N ASP 443.A OD2 no hydrogen 2.828 N/A HIS 8.A ND1 ASP 443.A OD2 no hydrogen 2.708 N/A HIS 8.A NE2 GLU 448.A OE1 no hydrogen 2.553 N/A TYR 9.A OH TYR 33.A OH no hydrogen 2.732 N/A GLU 12.A N GLU 60.A OE1 no hydrogen 2.866 N/A ASN 14.A N GLY 309.A O no hydrogen 2.826 N/A TRP 15.A N GLY 39.A O no hydrogen 3.161 N/A TRP 15.A NE1 ASN 17.A OD1 no hydrogen 2.698 N/A LEU 16.A N ARG 311.A O.A no hydrogen 3.009 N/A LEU 16.A N ARG 311.A O.B no hydrogen 3.023 N/A ASN 17.A N GLN 34.A O no hydrogen 2.893 N/A ASN 17.A ND2 ASP 18.A OD1 no hydrogen 2.999 N/A ASN 20.A N PHE 32.A O no hydrogen 2.822 N/A ASN 20.A ND2 PRO 19.A O no hydrogen 2.892 N/A ASN 20.A ND2 SER 75.A OG no hydrogen 2.936 N/A GLY 21.A N GLY 76.A O no hydrogen 2.949 N/A VAL 23.A N HIS 30.A O no hydrogen 3.252 N/A TYR 24.A N SER 283.A O no hydrogen 2.949 N/A LEU 25.A N THR 28.A O no hydrogen 2.866 N/A ASN 26.A ND2.A GLU 124.A OE2 no hydrogen 2.917 N/A ASN 26.A ND2.B GLU 124.A OE1 no hydrogen 2.552 N/A THR 28.A N LEU 25.A O no hydrogen 3.030 N/A TYR 29.A N SER 52.A O.A no hydrogen 2.776 N/A TYR 29.A N SER 52.A O.B no hydrogen 2.736 N/A HIS 30.A N VAL 23.A O no hydrogen 2.781 N/A HIS 30.A ND1 HIS 49.A NE2 no hydrogen 2.781 N/A LEU 31.A N ALA 50.A O no hydrogen 2.899 N/A PHE 32.A N ASN 20.A O no hydrogen 2.989 N/A TYR 33.A N GLY 48.A O no hydrogen 3.104 N/A TYR 33.A OH TYR 9.A OH no hydrogen 2.732 N/A GLN 34.A N ASP 18.A O no hydrogen 2.892 N/A GLN 34.A NE2 ASN 20.A OD1 no hydrogen 2.916 N/A GLN 34.A NE2 ILE 73.A O no hydrogen 2.891 N/A HIS 35.A ND1 TRP 15.A O no hydrogen 2.770 N/A ASN 36.A N TRP 15.A O no hydrogen 3.054 N/A ASN 36.A ND2 ASP 41.A O no hydrogen 2.827 N/A PHE 38.A N ASN 36.A OD1 no hydrogen 2.916 N/A ASN 44.A ND2 ASN 36.A OD1 no hydrogen 3.000 N/A SER 46.A N HIS 35.A O no hydrogen 2.952 N/A SER 46.A OG ASN 44.A O no hydrogen 2.924 N/A TRP 47.A N ILE 65.A O no hydrogen 2.895 N/A TRP 47.A NE1 PHE 74.A O no hydrogen 2.886 N/A GLY 48.A N TYR 33.A O no hydrogen 2.846 N/A HIS 49.A NE2 HIS 30.A ND1 no hydrogen 2.781 N/A ALA 50.A N LEU 31.A O no hydrogen 2.762 N/A THR 51.A N ASP 59.A O no hydrogen 2.954 N/A SER 52.A N.A TYR 29.A O no hydrogen 2.996 N/A SER 52.A N.B TYR 29.A O no hydrogen 3.008 N/A SER 52.A OG.B HIS 57.A O no hydrogen 2.966 N/A ASP 54.A N SER 52.A OG.B no hydrogen 3.050 N/A LEU 55.A N SER 52.A OG.A no hydrogen 3.040 N/A LEU 55.A N SER 52.A OG.B no hydrogen 2.956 N/A LEU 56.A N ASP 54.A OD1 no hydrogen 2.951 N/A HIS 57.A N ASP 54.A OD1 no hydrogen 2.884 N/A HIS 57.A ND1 ASP 54.A OD2 no hydrogen 2.699 N/A ASP 59.A N THR 51.A O no hydrogen 2.774 N/A GLN 61.A N HIS 49.A O no hydrogen 2.770 N/A GLN 61.A NE2 THR 51.A OG1 no hydrogen 3.118 N/A GLN 61.A NE2 ASP 59.A O no hydrogen 3.346 N/A ALA 64.A N TRP 47.A O no hydrogen 2.820 N/A CYS 67.A N SER 46.A OG no hydrogen 3.168 N/A CYS 67.A SG ASN 44.A O no hydrogen 3.401 N/A CYS 67.A SG SER 46.A OG no hydrogen 3.541 N/A ASP 68.A N GLU 71.A O no hydrogen 2.892 N/A GLU 69.A N GLU 69.A OE2 no hydrogen 2.751 N/A HIS 70.A N ASP 68.A OD1 no hydrogen 2.808 N/A GLU 71.A N ASP 68.A OD1 no hydrogen 2.938 N/A ALA 72.A N ALA 103.A O no hydrogen 2.937 N/A ILE 73.A N MET 45.A O no hydrogen 2.800 N/A PHE 74.A N THR 101.A O no hydrogen 2.807 N/A SER 75.A OG ASP 18.A OD2 no hydrogen 2.731 N/A SER 77.A N ILE 99.A O no hydrogen 2.903 N/A SER 77.A OG PRO 147.A O no hydrogen 2.726 N/A VAL 79.A N VAL 97.A O no hydrogen 2.885 N/A ASP 81.A N PRO 95.A O no hydrogen 2.970 N/A ASN 84.A N ASP 81.A O no hydrogen 2.882 N/A ASN 84.A ND2 GLY 89.A O no hydrogen 3.070 N/A THR 85.A N ASP 81.A OD1 no hydrogen 2.931 N/A THR 85.A OG1 ASP 81.A OD1 no hydrogen 2.784 N/A THR 85.A OG1 ASP 81.A OD2 no hydrogen 3.535 N/A SER 86.A N ASP 81.A OD2 no hydrogen 2.828 N/A SER 86.A OG ASP 81.A OD2 no hydrogen 2.751 N/A GLY 87.A N ASN 84.A O no hydrogen 3.060 N/A LEU 88.A N SER 86.A OG no hydrogen 3.169 N/A GLY 89.A N ASN 84.A OD1 no hydrogen 2.939 N/A THR 90.A N ASN 93.A O no hydrogen 3.037 N/A ASN 93.A N THR 90.A O no hydrogen 3.189 N/A ASN 93.A N THR 90.A OG1 no hydrogen 2.895 N/A ASN 93.A ND2 LEU 122.A O no hydrogen 3.382 N/A LEU 96.A N SER 121.A O no hydrogen 3.009 N/A VAL 97.A N VAL 79.A O no hydrogen 2.887 N/A ALA 98.A N ALA 119.A O no hydrogen 2.775 N/A ILE 99.A N SER 77.A O no hydrogen 2.828 N/A TYR 100.A N SER 117.A O no hydrogen 2.872 N/A TYR 100.A OH GLU 71.A OE1 no hydrogen 2.914 N/A TYR 100.A OH GLU 71.A OE2 no hydrogen 3.365 N/A THR 101.A N SER 75.A O no hydrogen 3.107 N/A THR 101.A OG1 SER 75.A O no hydrogen 3.444 N/A THR 101.A OG1 GLN 116.A OE1 no hydrogen 2.713 N/A SER 102.A N ALA 115.A O no hydrogen 2.752 N/A SER 102.A OG GLU 71.A OE1 no hydrogen 2.706 N/A SER 102.A OG SER 117.A OG no hydrogen 2.732 N/A ALA 103.A N ALA 72.A O no hydrogen 2.923 N/A TYR 104.A N ARG 113.A O no hydrogen 2.939 N/A SER 105.A N HIS 70.A O no hydrogen 2.882 N/A SER 105.A OG GLU 69.A O no hydrogen 2.705 N/A SER 105.A OG HIS 70.A O no hydrogen 3.440 N/A ALA 107.A N SER 105.A OG no hydrogen 3.103 N/A ALA 108.A N SER 105.A O no hydrogen 3.183 N/A GLY 112.A N TYR 104.A O no hydrogen 3.092 N/A ARG 113.A N LEU 110.A O no hydrogen 3.492 N/A ARG 113.A NH1 ASP 138.A OD1 no hydrogen 3.531 N/A ARG 113.A NH1 ASP 138.A OD2 no hydrogen 2.703 N/A GLN 114.A N SER 141.A O no hydrogen 2.893 N/A ALA 115.A N SER 102.A O no hydrogen 3.087 N/A GLN 116.A N LEU 137.A O no hydrogen 2.806 N/A GLN 116.A NE2 PHE 144.A O no hydrogen 2.881 N/A SER 117.A N TYR 100.A O no hydrogen 2.807 N/A SER 117.A OG SER 102.A OG no hydrogen 2.732 N/A LEU 118.A N ASN 134.A OD1 no hydrogen 2.842 N/A ALA 119.A N ALA 98.A O no hydrogen 2.950 N/A TYR 120.A N THR 129.A O no hydrogen 2.856 N/A SER 121.A N LEU 96.A O no hydrogen 2.864 N/A SER 121.A OG ASP 123.A OD1 no hydrogen 2.819 N/A SER 121.A OG THR 127.A O no hydrogen 2.827 N/A ASP 123.A N SER 121.A OG no hydrogen 3.365 N/A GLY 125.A N SER 121.A OG no hydrogen 2.814 N/A ARG 126.A N ASP 123.A O no hydrogen 3.397 N/A ARG 126.A NH2 ASP 123.A O no hydrogen 2.853 N/A THR 127.A N ASP 123.A OD1 no hydrogen 2.859 N/A THR 127.A OG1 ASP 123.A OD1 no hydrogen 3.379 N/A THR 127.A OG1 ASP 123.A OD2 no hydrogen 2.642 N/A TRP 128.A NE1 GLY 125.A O no hydrogen 2.901 N/A THR 129.A N TYR 120.A O no hydrogen 2.945 N/A LYS 130.A NZ PRO 66.A O no hydrogen 2.814 N/A LYS 130.A NZ GLU 71.A OE2 no hydrogen 2.779 N/A TYR 131.A N LEU 118.A O no hydrogen 2.933 N/A ASN 134.A N TYR 131.A O no hydrogen 3.199 N/A ASN 134.A ND2 LEU 118.A O no hydrogen 2.960 N/A VAL 136.A N GLN 116.A O no hydrogen 2.714 N/A LEU 137.A N GLN 116.A O no hydrogen 3.164 N/A ARG 139.A NE GLU 166.A OE1 no hydrogen 2.790 N/A ARG 139.A NH1 TYR 175.A OH no hydrogen 2.861 N/A ALA 140.A N ASP 138.A OD1 no hydrogen 2.869 N/A SER 141.A OG GLU 166.A OE1 no hydrogen 3.434 N/A SER 141.A OG GLU 166.A OE2 no hydrogen 2.694 N/A ASP 143.A N SER 141.A OG no hydrogen 3.009 N/A ARG 145.A N VAL 165.A O no hydrogen 2.955 N/A ARG 145.A NE GLU 200.A OE2 no hydrogen 3.199 N/A ARG 145.A NH1 GLN 114.A OE1 no hydrogen 2.862 N/A ARG 145.A NH1 ASP 143.A OD1 no hydrogen 2.898 N/A ARG 145.A NH2 GLU 200.A OE2 no hydrogen 2.818 N/A ASP 146.A N THR 101.A OG1 no hydrogen 2.851 N/A LYS 148.A N VAL 163.A O.A no hydrogen 2.755 N/A LYS 148.A N VAL 163.A O.B no hydrogen 2.820 N/A LYS 148.A NZ SER 281.A O no hydrogen 2.900 N/A VAL 149.A N SER 77.A OG no hydrogen 3.010 N/A PHE 150.A N VAL 161.A O no hydrogen 2.903 N/A TRP 151.A NE1 ASP 153.A OD1 no hydrogen 2.975 N/A TYR 152.A N TYR 159.A O no hydrogen 2.822 N/A GLY 154.A N GLY 157.A O no hydrogen 2.936 N/A GLY 157.A N GLY 154.A O no hydrogen 3.027 N/A SER 158.A OG ASP 153.A OD1 no hydrogen 2.700 N/A TYR 159.A N TYR 152.A O no hydrogen 2.952 N/A TYR 159.A OH GLY 244.A O no hydrogen 2.685 N/A TRP 160.A N SER 177.A O no hydrogen 2.867 N/A TRP 160.A NE1 THR 85.A OG1 no hydrogen 2.946 N/A VAL 161.A N PHE 150.A O no hydrogen 2.757 N/A MET 162.A N TYR 175.A O no hydrogen 2.777 N/A VAL 163.A N.A LYS 148.A O no hydrogen 2.862 N/A VAL 163.A N.B LYS 148.A O no hydrogen 2.865 N/A ALA 164.A N VAL 173.A O no hydrogen 2.955 N/A VAL 165.A N ARG 145.A O no hydrogen 2.937 N/A GLU 166.A N GLN 171.A O no hydrogen 2.958 N/A ALA 167.A N ASP 143.A O no hydrogen 2.882 N/A GLN 169.A NE2 GLN 171.A OE1 no hydrogen 2.821 N/A ARG 170.A N.A ALA 167.A O no hydrogen 3.188 N/A ARG 170.A N.B ALA 167.A O no hydrogen 3.194 N/A ARG 170.A NE.A THR 195.A O no hydrogen 3.084 N/A ARG 170.A NE.B VAL 168.A O no hydrogen 2.880 N/A ARG 170.A NH1.A VAL 168.A O no hydrogen 2.679 N/A ARG 170.A NH1.B THR 195.A O no hydrogen 2.879 N/A GLN 171.A N GLU 166.A O no hydrogen 3.379 N/A GLN 171.A NE2 GLY 190.A O no hydrogen 2.952 N/A VAL 172.A N PHE 189.A O no hydrogen 2.927 N/A VAL 173.A N ALA 164.A O no hydrogen 2.827 N/A LEU 174.A N.A SER 187.A O no hydrogen 2.863 N/A LEU 174.A N.B SER 187.A O no hydrogen 2.870 N/A TYR 175.A N MET 162.A O no hydrogen 2.979 N/A LYS 176.A N GLU 184.A O no hydrogen 2.873 N/A SER 177.A N TRP 160.A O no hydrogen 2.917 N/A SER 177.A OG ALA 182.A O no hydrogen 2.718 N/A ASP 179.A N SER 177.A OG no hydrogen 3.073 N/A LEU 180.A N SER 177.A OG no hydrogen 2.881 N/A LYS 181.A N.A ASP 179.A OD1 no hydrogen 2.854 N/A LYS 181.A N.B ASP 179.A OD1 no hydrogen 2.854 N/A LYS 181.A NZ.A SER 86.A O no hydrogen 2.949 N/A LYS 181.A NZ.B SER 86.A O no hydrogen 2.878 N/A ALA 182.A N ASP 179.A OD1 no hydrogen 2.910 N/A TRP 183.A NE1 LEU 180.A O no hydrogen 2.873 N/A GLU 184.A N LYS 176.A O no hydrogen 2.851 N/A HIS 185.A NE2 THR 188.A OG1 no hydrogen 2.994 N/A LEU 186.A N LEU 174.A O.A no hydrogen 2.789 N/A LEU 186.A N LEU 174.A O.B no hydrogen 2.760 N/A SER 187.A N LEU 174.A O.A no hydrogen 3.460 N/A SER 187.A N LEU 174.A O.B no hydrogen 3.387 N/A SER 187.A OG VAL 245.A O no hydrogen 2.664 N/A THR 188.A OG1 HIS 185.A NE2 no hydrogen 2.994 N/A PHE 189.A N VAL 172.A O no hydrogen 2.805 N/A ASN 193.A N THR 254.A O no hydrogen 2.873 N/A ASN 193.A ND2 SER 251.A O no hydrogen 3.269 N/A ALA 194.A N GLN 236.A OE1 no hydrogen 3.009 N/A THR 195.A N GLN 258.A OE1 no hydrogen 2.859 N/A VAL 198.A N ASN 225.A O no hydrogen 2.931 N/A TRP 199.A N ALA 167.A O no hydrogen 3.124 N/A TRP 199.A NE1 ALA 194.A O no hydrogen 2.923 N/A GLU 200.A N ASN 223.A O no hydrogen 2.791 N/A CYS 201.A N ASP 146.A OD2 no hydrogen 2.901 N/A CYS 201.A SG ASP 18.A OD2 no hydrogen 3.256 N/A CYS 201.A SG ASP 146.A OD2 no hydrogen 3.631 N/A ASP 203.A N ILE 221.A O no hydrogen 3.108 N/A LEU 204.A N ASP 203.A OD1 no hydrogen 2.794 N/A PHE 205.A N VAL 219.A O no hydrogen 3.086 N/A LEU 207.A N ARG 217.A O no hydrogen 2.879 N/A VAL 209.A N ASP 215.A O no hydrogen 2.789 N/A ASP 210.A N LEU 322.A O no hydrogen 2.853 N/A ASN 212.A N VAL 209.A O no hydrogen 3.008 N/A GLU 214.A N ASN 212.A OD1 no hydrogen 2.891 N/A ASP 215.A N ASN 212.A O no hydrogen 3.015 N/A ASN 216.A ND2 PRO 213.A O no hydrogen 2.861 N/A ARG 217.A N LEU 207.A O no hydrogen 2.979 N/A ARG 217.A NH1 ASP 215.A OD1 no hydrogen 2.898 N/A ARG 217.A NH1 ASN 216.A O no hydrogen 2.934 N/A TRP 218.A N GLY 240.A O no hydrogen 2.839 N/A VAL 219.A N PHE 205.A O no hydrogen 2.782 N/A LEU 220.A N PHE 238.A O no hydrogen 2.935 N/A ILE 221.A N ASP 203.A O no hydrogen 2.806 N/A VAL 222.A N GLN 236.A O no hydrogen 2.941 N/A ASN 223.A N GLU 200.A O no hydrogen 2.900 N/A ASN 223.A ND2 CYS 201.A O no hydrogen 2.855 N/A ASN 223.A ND2 ALA 279.A O no hydrogen 3.109 N/A ILE 224.A N ALA 234.A O no hydrogen 2.818 N/A ASN 225.A N VAL 198.A O no hydrogen 3.019 N/A GLY 228.A N GLY 232.A O no hydrogen 2.815 N/A GLY 231.A N GLY 228.A O no hydrogen 3.014 N/A SER 233.A N ASN 298.A OD1 no hydrogen 3.251 N/A ALA 234.A N ILE 224.A O no hydrogen 2.998 N/A GLN 236.A N VAL 222.A O no hydrogen 2.864 N/A GLN 236.A NE2 ALA 194.A O no hydrogen 2.960 N/A TYR 237.A N GLY 268.A O no hydrogen 2.782 N/A PHE 238.A N LEU 220.A O no hydrogen 2.843 N/A VAL 239.A N SER 251.A OG no hydrogen 2.903 N/A GLY 240.A N TRP 218.A O no hydrogen 2.820 N/A GLU 241.A N HIS 248.A O no hydrogen 2.908 N/A ASP 243.A N ALA 246.A O no hydrogen 3.060 N/A VAL 245.A N ASP 243.A OD1 no hydrogen 2.802 N/A ALA 246.A N ASP 243.A OD1 no hydrogen 2.803 N/A HIS 248.A N GLU 241.A O no hydrogen 2.719 N/A HIS 248.A NE2 ASP 243.A OD2 no hydrogen 2.666 N/A SER 249.A OG THR 252.A OG1 no hydrogen 2.780 N/A GLY 250.A N VAL 239.A O no hydrogen 2.718 N/A SER 251.A N SER 249.A OG no hydrogen 3.141 N/A THR 252.A OG1 SER 249.A OG no hydrogen 2.780 N/A VAL 253.A N ASN 193.A OD1 no hydrogen 2.726 N/A THR 254.A N ASN 193.A OD1 no hydrogen 3.249 N/A THR 254.A OG1 TYR 267.A OH no hydrogen 2.686 N/A GLY 256.A N PRO 191.A O no hydrogen 2.810 N/A GLN 258.A N THR 195.A OG1 no hydrogen 2.864 N/A GLN 258.A NE2 ASP 260.A O no hydrogen 2.983 N/A SER 262.A N ASP 260.A OD1 no hydrogen 2.902 N/A SER 262.A OG ASP 260.A OD1 no hydrogen 2.616 N/A ARG 263.A NE GLU 266.A OE1 no hydrogen 3.327 N/A ARG 263.A NE GLU 266.A OE2 no hydrogen 2.794 N/A ARG 263.A NH2 GLU 266.A OE1 no hydrogen 2.813 N/A MET 264.A N SER 261.A O no hydrogen 3.234 N/A ARG 265.A NH1 ALA 426.A O no hydrogen 2.968 N/A GLU 266.A N ARG 263.A O no hydrogen 2.891 N/A TYR 267.A N MET 264.A O no hydrogen 3.192 N/A TYR 267.A OH THR 254.A OG1 no hydrogen 2.686 N/A TRP 269.A NE1 MET 264.A O no hydrogen 2.863 N/A LEU 270.A N GLY 235.A O no hydrogen 2.859 N/A TRP 272.A N THR 457.A O no hydrogen 2.817 N/A GLY 273.A N ASP 271.A OD1 no hydrogen 2.739 N/A ARG 274.A N ASP 460.A OD1 no hydrogen 2.893 N/A ARG 274.A NE GLY 231.A O no hydrogen 2.967 N/A ARG 274.A NH1 THR 420.A O no hydrogen 2.901 N/A ARG 274.A NH1 PHE 421.A O no hydrogen 3.356 N/A ARG 274.A NH1 SER 423.A OG no hydrogen 2.947 N/A ARG 274.A NH2 ASP 300.A OD2 no hydrogen 2.888 N/A ARG 274.A NH2 THR 420.A O no hydrogen 2.863 N/A ASP 275.A N THR 459.A O no hydrogen 2.968 N/A TYR 277.A N TRP 295.A O no hydrogen 2.964 N/A TYR 277.A OH GLU 200.A OE1 no hydrogen 2.729 N/A ALA 278.A N ASN 223.A OD1 no hydrogen 2.945 N/A VAL 280.A N ILE 293.A O.A no hydrogen 3.385 N/A VAL 280.A N ILE 293.A O.B no hydrogen 3.355 N/A SER 281.A N ASP 203.A OD2 no hydrogen 2.881 N/A SER 281.A OG ASP 203.A OD2 no hydrogen 2.651 N/A PHE 282.A N ILE 291.A O.A no hydrogen 2.951 N/A PHE 282.A N ILE 291.A O.B no hydrogen 2.958 N/A SER 283.A N LEU 22.A O no hydrogen 2.893 N/A ASN 284.A ND2 TYR 24.A O no hydrogen 2.834 N/A ARG 289.A N PRO 286.A O no hydrogen 3.237 N/A ARG 290.A NH1 SER 281.A OG no hydrogen 2.875 N/A MET 292.A N ARG 318.A O no hydrogen 2.880 N/A ILE 293.A N.A VAL 280.A O no hydrogen 3.219 N/A ILE 293.A N.B VAL 280.A O no hydrogen 3.224 N/A GLY 294.A N SER 315.A OG no hydrogen 2.960 N/A TRP 295.A N TYR 277.A O no hydrogen 2.771 N/A TRP 295.A NE1 SER 312.A OG no hydrogen 2.912 N/A MET 296.A N ALA 313.A O no hydrogen 2.932 N/A ASN 297.A ND2 THR 305.A OG1 no hydrogen 3.394 N/A ASN 297.A ND2 SER 312.A OG no hydrogen 2.892 N/A ASN 298.A N ASN 297.A OD1 no hydrogen 2.831 N/A ASN 298.A ND2 GLY 231.A O no hydrogen 3.095 N/A ASN 298.A ND2 ARG 274.A O no hydrogen 2.814 N/A TRP 299.A N SER 233.A OG no hydrogen 3.063 N/A ASP 300.A N ASN 298.A OD1 no hydrogen 2.782 N/A TYR 301.A N ASN 298.A O no hydrogen 3.098 N/A TYR 301.A OH ASP 275.A OD1 no hydrogen 2.535 N/A TYR 301.A OH ASP 275.A OD2 no hydrogen 3.122 N/A ALA 302.A N ASN 298.A O no hydrogen 2.837 N/A GLU 304.A N TYR 301.A O no hydrogen 2.916 N/A THR 305.A N ALA 302.A O no hydrogen 3.111 N/A THR 305.A OG1 ALA 302.A O no hydrogen 2.740 N/A THR 307.A N THR 305.A O no hydrogen 2.942 N/A THR 307.A OG1 TRP 310.A O no hydrogen 2.695 N/A TRP 310.A NE1 ASP 1.A OD1 no hydrogen 2.867 N/A ARG 311.A N.A ASN 14.A O no hydrogen 3.005 N/A ARG 311.A N.B ASN 14.A O no hydrogen 3.000 N/A ARG 311.A NE.A ARG 303.A O no hydrogen 3.305 N/A ARG 311.A NE.B ALA 40.A O no hydrogen 3.320 N/A ARG 311.A NH2.A GLY 308.A O no hydrogen 2.924 N/A ARG 311.A NH2.B THR 305.A O no hydrogen 2.855 N/A MET 314.A N TYR 9.A O no hydrogen 2.937 N/A SER 315.A N GLY 294.A O no hydrogen 2.816 N/A SER 315.A OG GLY 294.A O no hydrogen 3.434 N/A SER 315.A OG LEU 316.A O no hydrogen 2.835 N/A LEU 316.A N GLU 448.A OE2 no hydrogen 3.003 N/A ARG 318.A N MET 292.A O no hydrogen 2.811 N/A ARG 318.A NH1 ASP 271.A OD2 no hydrogen 2.907 N/A ARG 318.A NH2 LEU 270.A O no hydrogen 3.257 N/A ARG 318.A NH2 GLN 333.A OE1 no hydrogen 2.915 N/A ARG 318.A NH2 THR 457.A OG1 no hydrogen 3.033 N/A GLU 319.A N GLN 334.A O no hydrogen 2.795 N/A VAL 320.A N ARG 290.A O no hydrogen 2.881 N/A SER 321.A N ARG 332.A O no hydrogen 2.875 N/A THR 323.A N MET 330.A O no hydrogen 2.931 N/A THR 323.A OG1 ASP 210.A OD1 no hydrogen 2.579 N/A ARG 324.A N ASP 210.A OD2 no hydrogen 2.753 N/A ARG 324.A NH1 ASP 215.A OD2 no hydrogen 2.822 N/A ARG 324.A NH2 ASP 215.A OD2 no hydrogen 3.152 N/A LYS 328.A N VAL 325.A O no hydrogen 3.421 N/A MET 330.A N THR 323.A O no hydrogen 2.851 N/A LEU 331.A N TYR 237.A OH no hydrogen 3.037 N/A ARG 332.A N SER 321.A O no hydrogen 2.809 N/A ARG 332.A NH1 ASP 453.A O no hydrogen 3.115 N/A ARG 332.A NH2 THR 323.A OG1 no hydrogen 3.113 N/A GLN 333.A N GLY 454.A O no hydrogen 2.933 N/A GLN 333.A NE2 LEU 270.A O no hydrogen 2.841 N/A GLN 334.A N GLU 319.A O no hydrogen 2.999 N/A ILE 336.A N PRO 317.A O no hydrogen 2.884 N/A LEU 339.A N ASP 337.A OD2 no hydrogen 3.024 N/A THR 344.A N GLU 341.A O no hydrogen 3.369 N/A THR 344.A OG1 PRO 340.A O no hydrogen 2.542 N/A THR 344.A OG1 GLU 341.A O no hydrogen 3.441 N/A GLY 345.A N GLY 489.A O no hydrogen 2.862 N/A HIS 346.A NE2 ASP 486.A OD1 no hydrogen 2.577 N/A VAL 347.A N VAL 487.A O no hydrogen 2.877 N/A ARG 348.A NE ASP 486.A OD1 no hydrogen 2.698 N/A ARG 348.A NH2 ASP 486.A OD1 no hydrogen 3.333 N/A LEU 349.A N LEU 485.A O no hydrogen 2.826 N/A GLN 352.A N LEU 482.A O no hydrogen 3.000 N/A LEU 354.A N ALA 480.A O no hydrogen 2.970 N/A SER 356.A N GLU 478.A OE2 no hydrogen 3.042 N/A GLY 357.A N ALA 475.A O no hydrogen 2.856 N/A LEU 359.A N ILE 473.A O no hydrogen 2.692 N/A VAL 361.A N LEU 471.A O no hydrogen 3.029 N/A ALA 363.A N VAL 361.A O no hydrogen 2.903 N/A ALA 365.A N THR 469.A O no hydrogen 2.857 N/A ALA 368.A N LEU 442.A O no hydrogen 2.875 N/A ARG 369.A N VAL 488.A O no hydrogen 2.885 N/A ARG 369.A NE ASP 371.A OD2 no hydrogen 2.869 N/A ARG 369.A NH2 ASP 337.A OD1 no hydrogen 2.907 N/A ARG 369.A NH2 LEU 339.A O no hydrogen 2.929 N/A ILE 370.A N VAL 440.A O no hydrogen 2.803 N/A ASP 371.A N ASP 486.A O no hydrogen 2.813 N/A VAL 372.A N LEU 438.A O no hydrogen 2.917 N/A GLU 373.A N VAL 484.A O no hydrogen 2.904 N/A LEU 374.A N LEU 436.A O no hydrogen 2.862 N/A GLU 375.A N HIS 481.A O no hydrogen 2.860 N/A ALA 379.A N PRO 376.A O no hydrogen 3.063 N/A ALA 380.A N GLU 476.A O no hydrogen 2.803 N/A VAL 382.A N TYR 398.A O no hydrogen 3.082 N/A GLY 383.A N PHE 474.A O no hydrogen 2.953 N/A LEU 384.A N LEU 396.A O no hydrogen 2.894 N/A VAL 385.A N ALA 472.A O no hydrogen 2.837 N/A LEU 386.A N THR 394.A O no hydrogen 2.804 N/A ARG 387.A NE SER 468.A O no hydrogen 2.840 N/A ARG 387.A NH1 ARG 444.A O no hydrogen 3.236 N/A ARG 387.A NH2 GLY 465.A O no hydrogen 3.431 N/A ALA 388.A N GLY 470.A O no hydrogen 3.012 N/A GLY 389.A N GLU 392.A O no hydrogen 2.842 N/A GLU 392.A N GLY 389.A O no hydrogen 3.351 N/A ARG 393.A N GLU 411.A O no hydrogen 2.939 N/A ARG 393.A NH1 GLU 411.A OE1 no hydrogen 2.808 N/A THR 394.A N LEU 386.A O no hydrogen 2.904 N/A VAL 395.A N ASP 408.A O no hydrogen 3.104 N/A LEU 396.A N LEU 384.A O no hydrogen 2.916 N/A ARG 397.A N ARG 406.A O no hydrogen 2.835 N/A ARG 397.A NE GLU 476.A OE1 no hydrogen 3.251 N/A ARG 397.A NE GLU 476.A OE2 no hydrogen 2.847 N/A ARG 397.A NH1 ASP 399.A OD2 no hydrogen 2.990 N/A ARG 397.A NH2 GLU 476.A OE1 no hydrogen 2.826 N/A TYR 398.A N VAL 382.A O no hydrogen 2.766 N/A TYR 398.A OH VAL 429.A O no hydrogen 2.745 N/A ASP 399.A N MET 404.A O no hydrogen 2.935 N/A THR 400.A N ALA 380.A O no hydrogen 3.162 N/A THR 400.A OG1 ALA 379.A O no hydrogen 2.639 N/A THR 400.A OG1 ALA 380.A O no hydrogen 3.154 N/A SER 401.A N ASP 399.A OD1 no hydrogen 2.857 N/A SER 401.A OG ASP 399.A OD1 no hydrogen 2.620 N/A GLY 403.A N ASP 399.A O no hydrogen 2.824 N/A MET 404.A N ASP 402.A OD1 no hydrogen 3.204 N/A LEU 405.A N MET 427.A O no hydrogen 2.836 N/A ARG 406.A N ARG 397.A O no hydrogen 2.890 N/A ARG 406.A NH1 ASP 402.A OD2 no hydrogen 2.804 N/A ARG 406.A NH2 ASP 402.A OD1 no hydrogen 3.526 N/A ARG 406.A NH2 ASP 402.A OD2 no hydrogen 3.468 N/A LEU 407.A N GLU 425.A O no hydrogen 2.856 N/A ASP 408.A N VAL 395.A O no hydrogen 2.838 N/A ARG 409.A N SER 423.A O no hydrogen 3.033 N/A ARG 409.A NE PHE 421.A O no hydrogen 3.022 N/A ARG 409.A NH1 ASP 275.A OD2 no hydrogen 2.805 N/A ARG 409.A NH1 LEU 461.A O no hydrogen 2.904 N/A ARG 409.A NH2 TYR 301.A OH no hydrogen 2.836 N/A ARG 409.A NH2 PHE 421.A O no hydrogen 3.017 N/A ARG 410.A N.A ASP 408.A OD1 no hydrogen 2.899 N/A ARG 410.A N.B ASP 408.A OD1 no hydrogen 2.889 N/A ARG 410.A NE.A ASP 408.A OD2 no hydrogen 3.104 N/A ARG 410.A NH2.A ASP 408.A OD2 no hydrogen 2.813 N/A SER 412.A N ARG 409.A O no hydrogen 3.155 N/A SER 412.A OG ARG 409.A O no hydrogen 2.700 N/A GLN 414.A N.A PHE 463.A O no hydrogen 2.881 N/A GLN 414.A N.B PHE 463.A O no hydrogen 2.876 N/A GLU 419.A N GLU 419.A OE1 no hydrogen 2.772 N/A THR 420.A N HIS 418.A ND1 no hydrogen 3.103 N/A THR 420.A OG1 HIS 418.A ND1 no hydrogen 2.869 N/A PHE 421.A N HIS 418.A O no hydrogen 2.933 N/A SER 423.A OG PHE 421.A O no hydrogen 3.270 N/A SER 423.A OG GLU 425.A OE1 no hydrogen 2.742 N/A SER 423.A OG GLU 425.A OE2 no hydrogen 3.092 N/A GLU 425.A N LEU 407.A O no hydrogen 2.929 N/A MET 427.A N LEU 405.A O no hydrogen 2.925 N/A VAL 429.A N GLY 403.A O no hydrogen 3.015 N/A GLN 432.A N.A ARG 435.A O no hydrogen 2.951 N/A GLN 432.A N.B ARG 435.A O no hydrogen 2.957 N/A ARG 435.A N GLN 432.A O.A no hydrogen 2.908 N/A ARG 435.A N GLN 432.A O.B no hydrogen 2.988 N/A ARG 435.A NE GLU 375.A OE1 no hydrogen 3.111 N/A ARG 435.A NH1 GLU 373.A OE1 no hydrogen 2.981 N/A LEU 436.A N LEU 374.A O no hydrogen 2.836 N/A ARG 437.A N GLN 452.A OE1 no hydrogen 2.820 N/A ARG 437.A NE ASP 453.A OD2 no hydrogen 2.819 N/A ARG 437.A NH1 GLU 373.A OE2 no hydrogen 3.018 N/A ARG 437.A NH2 ASP 453.A OD1 no hydrogen 3.023 N/A LEU 438.A N VAL 372.A O no hydrogen 2.890 N/A ARG 439.A N PHE 450.A O no hydrogen 2.907 N/A ARG 439.A NE ASP 371.A OD1 no hydrogen 2.725 N/A ARG 439.A NH2 ASP 371.A OD1 no hydrogen 3.360 N/A ARG 439.A NH2 ASP 371.A OD2 no hydrogen 3.280 N/A VAL 440.A N ILE 370.A O no hydrogen 2.787 N/A TYR 441.A N GLU 448.A O no hydrogen 2.833 N/A TYR 441.A OH ASP 337.A OD1 no hydrogen 2.535 N/A LEU 442.A N ALA 368.A O no hydrogen 2.822 N/A ASP 443.A N SER 446.A O no hydrogen 3.076 N/A ARG 444.A N ASP 443.A OD1 no hydrogen 2.747 N/A ARG 444.A NH1 ARG 4.A O no hydrogen 2.778 N/A CYS 445.A SG TYR 3.A O no hydrogen 3.503 N/A SER 446.A N ASP 443.A O no hydrogen 3.127 N/A VAL 447.A N ASP 460.A O no hydrogen 2.853 N/A GLU 448.A N TYR 441.A O no hydrogen 2.987 N/A VAL 449.A N LEU 458.A O no hydrogen 2.824 N/A PHE 450.A N ARG 439.A O no hydrogen 2.796 N/A ALA 451.A N ALA 456.A O no hydrogen 2.789 N/A GLN 452.A N ARG 437.A O no hydrogen 2.829 N/A GLN 452.A NE2 PRO 430.A O no hydrogen 2.918 N/A GLN 452.A NE2 ARG 435.A O no hydrogen 3.115 N/A GLY 454.A N ALA 451.A O no hydrogen 3.040 N/A LEU 455.A N ALA 451.A O no hydrogen 3.085 N/A THR 457.A OG1 LEU 270.A O no hydrogen 3.151 N/A THR 457.A OG1 ASP 271.A OD2 no hydrogen 2.757 N/A LEU 458.A N VAL 449.A O no hydrogen 2.894 N/A THR 459.A N ASP 271.A OD1 no hydrogen 2.838 N/A THR 459.A OG1 ASP 271.A OD2 no hydrogen 2.830 N/A ASP 460.A N VAL 447.A O no hydrogen 2.967 N/A LEU 461.A N ASP 275.A OD2 no hydrogen 2.754 N/A VAL 462.A N CYS 445.A O no hydrogen 3.011 N/A GLY 465.A N GLU 392.A OE1 no hydrogen 2.738 N/A SER 468.A N GLY 465.A O no hydrogen 2.959 N/A SER 468.A OG GLU 392.A OE1 no hydrogen 2.600 N/A THR 469.A N ALA 467.A O no hydrogen 3.028 N/A GLY 470.A N ALA 388.A O no hydrogen 2.883 N/A ALA 472.A N VAL 385.A O no hydrogen 3.071 N/A ILE 473.A N LEU 359.A O no hydrogen 2.871 N/A PHE 474.A N GLY 383.A O no hydrogen 2.908 N/A ALA 475.A N GLY 357.A O no hydrogen 3.022 N/A GLU 476.A N GLY 381.A O no hydrogen 2.815 N/A GLY 477.A N SER 356.A OG no hydrogen 2.954 N/A HIS 481.A N GLU 375.A O no hydrogen 2.873 N/A LEU 482.A N GLN 352.A O no hydrogen 2.812 N/A VAL 483.A N GLU 373.A O no hydrogen 2.892 N/A VAL 484.A N GLU 373.A O no hydrogen 3.413 N/A LEU 485.A N LEU 349.A O no hydrogen 2.950 N/A ASP 486.A N ASP 371.A O no hydrogen 2.787 N/A VAL 487.A N VAL 347.A O no hydrogen 2.878 N/A VAL 488.A N ARG 369.A O no hydrogen 2.929 N/A GLY 489.A N GLY 345.A O no hydrogen 3.074 N/A