Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8v4x_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ALA 3.A N PRO 226.A O no hydrogen 2.851 N/A LYS 4.A N GLY 68.A O no hydrogen 3.034 N/A LYS 6.A N ASP 5.A OD1 no hydrogen 2.740 N/A LYS 6.A NZ LEU 39.A O no hydrogen 2.781 N/A LYS 6.A NZ LEU 223.A O no hydrogen 2.787 N/A LYS 6.A NZ ASP 225.A O no hydrogen 2.815 N/A VAL 7.A N TYR 70.A O no hydrogen 2.926 N/A ALA 8.A N LYS 42.A O no hydrogen 3.057 N/A LEU 9.A N LEU 72.A O no hydrogen 2.910 N/A LEU 10.A N VAL 44.A O no hydrogen 2.839 N/A ILE 11.A N TYR 74.A O no hydrogen 2.899 N/A GLY 12.A N LEU 46.A O no hydrogen 2.887 N/A ASN 13.A N ALA 76.A O no hydrogen 2.983 N/A ASN 13.A ND2 VAL 89.A O no hydrogen 3.462 N/A MET 14.A N ASP 48.A OD1 no hydrogen 2.802 N/A ASN 15.A N ASP 48.A OD1 no hydrogen 3.111 N/A TYR 16.A N MET 14.A O no hydrogen 2.919 N/A TYR 16.A OH VAL 89.A O no hydrogen 2.535 N/A ARG 17.A N VAL 91.A O no hydrogen 3.319 N/A HIS 19.A NE2 PRO 94.A O no hydrogen 2.914 N/A LYS 21.A NZ TYR 16.A O no hydrogen 2.749 N/A LEU 22.A N MET 14.A O no hydrogen 3.190 N/A LYS 23.A N GLU 163.A OE2 no hydrogen 3.179 N/A LYS 23.A NZ HIS 166.A O no hydrogen 3.453 N/A ALA 24.A N GLU 163.A OE2 no hydrogen 3.049 N/A ASP 28.A N ALA 24.A O no hydrogen 2.941 N/A VAL 29.A N PRO 25.A O no hydrogen 2.861 N/A TYR 30.A N LEU 26.A O no hydrogen 2.953 N/A GLU 31.A N VAL 27.A O no hydrogen 2.876 N/A LEU 32.A N ASP 28.A O no hydrogen 3.068 N/A THR 33.A N VAL 29.A O no hydrogen 2.912 N/A THR 33.A OG1 VAL 29.A O no hydrogen 2.847 N/A ASN 34.A N TYR 30.A O no hydrogen 3.388 N/A LEU 35.A N GLU 31.A O no hydrogen 3.081 N/A LEU 36.A N LEU 32.A O no hydrogen 2.943 N/A ARG 37.A N THR 33.A O no hydrogen 2.985 N/A GLN 38.A N ASN 34.A O no hydrogen 3.071 N/A ASP 40.A N ARG 37.A O no hydrogen 3.138 N/A PHE 41.A N LEU 36.A O no hydrogen 2.961 N/A LYS 42.A N LYS 6.A O no hydrogen 2.945 N/A LYS 42.A NZ ASP 5.A OD1 no hydrogen 2.747 N/A VAL 44.A N ALA 8.A O no hydrogen 3.152 N/A LEU 46.A N LEU 10.A O no hydrogen 2.798 N/A LEU 47.A N ASN 265.A OD1 no hydrogen 2.979 N/A ASP 48.A N GLY 12.A O no hydrogen 2.783 N/A LEU 49.A N ASN 13.A OD1 no hydrogen 3.014 N/A THR 50.A N GLU 53.A OE1 no hydrogen 3.304 N/A GLU 51.A N ASP 92.A OD1 no hydrogen 2.812 N/A MET 54.A N THR 50.A O no hydrogen 2.955 N/A ARG 55.A N GLU 51.A O no hydrogen 3.024 N/A ARG 55.A NE GLU 51.A OE2 no hydrogen 2.811 N/A ASN 56.A N TYR 52.A O no hydrogen 2.979 N/A ALA 57.A N GLU 53.A O no hydrogen 3.180 N/A VAL 58.A N MET 54.A O no hydrogen 2.913 N/A ASP 59.A N ARG 55.A O no hydrogen 3.093 N/A GLU 60.A N ASN 56.A O no hydrogen 3.155 N/A PHE 61.A N ALA 57.A O no hydrogen 3.089 N/A LEU 62.A N VAL 58.A O no hydrogen 3.138 N/A LEU 63.A N ASP 59.A O no hydrogen 3.230 N/A LEU 64.A N GLU 60.A O no hydrogen 3.327 N/A LEU 65.A N PHE 61.A O no hydrogen 3.249 N/A LEU 65.A N LEU 62.A O no hydrogen 3.096 N/A LYS 67.A N ASP 66.A OD2 no hydrogen 2.834 N/A VAL 69.A N ASP 66.A O no hydrogen 2.908 N/A TYR 70.A N ASP 5.A O no hydrogen 2.943 N/A TYR 70.A OH ASP 225.A OD2 no hydrogen 2.563 N/A GLY 71.A N LEU 119.A O no hydrogen 2.988 N/A LEU 72.A N VAL 7.A O no hydrogen 3.123 N/A LEU 73.A N VAL 121.A O no hydrogen 2.871 N/A TYR 74.A N LEU 9.A O no hydrogen 3.015 N/A TYR 74.A OH ASP 125.A OD2 no hydrogen 2.998 N/A TYR 75.A N LEU 123.A O no hydrogen 3.149 N/A TYR 75.A OH HIS 78.A O no hydrogen 2.876 N/A ALA 76.A N ILE 11.A O no hydrogen 3.121 N/A GLY 77.A N ASP 125.A O no hydrogen 3.469 N/A HIS 78.A N TYR 16.A OH no hydrogen 2.979 N/A HIS 78.A NE2 PRO 20.A O no hydrogen 2.775 N/A TYR 80.A N PHE 87.A O no hydrogen 3.220 N/A GLU 81.A N LYS 129.A O no hydrogen 3.109 N/A ASN 82.A N ASN 85.A O no hydrogen 3.061 N/A ASN 82.A ND2 ASN 131.A O no hydrogen 2.869 N/A ASN 82.A ND2 ASP 134.A OD2 no hydrogen 3.396 N/A ASN 85.A N ASN 82.A O no hydrogen 3.092 N/A ASN 85.A ND2 ASN 82.A O no hydrogen 3.378 N/A SER 86.A N GLN 106.A OE1 no hydrogen 3.317 N/A SER 86.A OG GLU 81.A OE1 no hydrogen 2.870 N/A PHE 87.A N TYR 80.A O no hydrogen 2.898 N/A MET 88.A N LEU 103.A O no hydrogen 2.887 N/A VAL 89.A N HIS 78.A O no hydrogen 2.924 N/A VAL 91.A N LEU 49.A O no hydrogen 3.211 N/A ALA 93.A N PRO 90.A O no hydrogen 3.078 N/A ASN 95.A N GLU 18.A OE1 no hydrogen 2.951 N/A ASN 95.A ND2 GLU 18.A O no hydrogen 2.980 N/A ARG 98.A N ASN 101.A OD1 no hydrogen 2.994 N/A SER 99.A N ASP 134.A OD1 no hydrogen 3.346 N/A SER 99.A OG ASP 134.A OD1 no hydrogen 3.354 N/A SER 99.A OG THR 136.A OG1 no hydrogen 3.399 N/A GLU 100.A N GLU 100.A OE1 no hydrogen 2.997 N/A ASN 101.A N ARG 98.A O no hydrogen 2.982 N/A CYS 102.A SG ARG 98.A O no hydrogen 3.554 N/A LEU 103.A N MET 88.A O no hydrogen 3.047 N/A CYS 104.A SG SER 86.A O no hydrogen 3.809 N/A VAL 105.A N SER 86.A O no hydrogen 2.921 N/A ILE 108.A N CYS 104.A O no hydrogen 3.153 N/A LEU 109.A N VAL 105.A O no hydrogen 3.087 N/A LYS 110.A N GLN 106.A O no hydrogen 3.441 N/A MET 112.A N ILE 108.A O no hydrogen 3.010 N/A GLN 113.A N LEU 109.A O no hydrogen 3.212 N/A GLN 113.A NE2 LYS 144.A O no hydrogen 2.898 N/A GLN 113.A NE2 THR 146.A OG1 no hydrogen 2.645 N/A GLU 114.A N LYS 110.A O no hydrogen 3.364 N/A LYS 115.A NZ LEU 63.A O no hydrogen 3.179 N/A LYS 115.A NZ LEU 65.A O no hydrogen 2.767 N/A GLU 116.A N GLN 113.A O no hydrogen 2.930 N/A THR 117.A OG1 MET 112.A O no hydrogen 2.801 N/A THR 117.A OG1 ASN 120.A OD1 no hydrogen 2.769 N/A GLY 118.A N VAL 69.A O no hydrogen 3.284 N/A ASN 120.A N ASN 148.A O no hydrogen 2.919 N/A VAL 121.A N GLY 71.A O no hydrogen 2.903 N/A PHE 122.A N VAL 150.A O no hydrogen 2.994 N/A LEU 123.A N LEU 73.A O no hydrogen 2.919 N/A LEU 124.A N GLY 152.A O no hydrogen 2.893 N/A ASP 125.A N TYR 75.A O no hydrogen 2.689 N/A CYS 127.A SG ALA 161.A O no hydrogen 3.770 N/A ARG 128.A N ALA 159.A O no hydrogen 2.881 N/A ARG 128.A NE GLU 81.A OE1 no hydrogen 2.927 N/A ARG 128.A NH1 THR 155.A O no hydrogen 2.991 N/A ARG 128.A NH1 GLU 212.A OE2 no hydrogen 2.806 N/A ARG 128.A NH2 GLU 81.A OE1 no hydrogen 3.230 N/A ARG 128.A NH2 GLU 81.A OE2 no hydrogen 3.150 N/A ARG 128.A NH2 GLU 212.A OE2 no hydrogen 3.287 N/A ARG 130.A NE ASP 132.A OD1 no hydrogen 3.298 N/A ASN 131.A N ASN 82.A OD1 no hydrogen 3.162 N/A ASN 131.A ND2 TYR 97.A O no hydrogen 3.120 N/A ASP 134.A N ASN 131.A O no hydrogen 3.300 N/A THR 136.A OG1 SER 99.A OG no hydrogen 3.399 N/A THR 136.A OG1 ASP 134.A OD1 no hydrogen 3.011 N/A LYS 144.A N GLN 113.A OE1 no hydrogen 3.292 N/A THR 146.A OG1 ASN 148.A OD1 no hydrogen 2.822 N/A ILE 149.A N SER 216.A OG no hydrogen 3.123 N/A VAL 150.A N ASN 120.A O no hydrogen 2.907 N/A PHE 151.A N ARG 214.A O no hydrogen 2.836 N/A GLY 152.A N PHE 122.A O no hydrogen 2.855 N/A TYR 153.A N GLU 212.A O no hydrogen 2.788 N/A ALA 154.A N LEU 124.A O no hydrogen 3.054 N/A THR 155.A OG1 GLU 160.A O no hydrogen 2.781 N/A CYS 156.A SG ALA 210.A O no hydrogen 3.537 N/A GLY 158.A N ARG 128.A O no hydrogen 2.997 N/A ALA 159.A N CYS 156.A O no hydrogen 3.232 N/A PHE 162.A N GLN 209.A OE1 no hydrogen 2.877 N/A SER 167.A OG GLN 165.A O no hydrogen 2.979 N/A ASN 171.A ND2 GLU 31.A OE1 no hydrogen 2.999 N/A GLY 172.A N ASP 28.A OD1 no hydrogen 3.213 N/A GLY 172.A N ASP 28.A OD2 no hydrogen 3.316 N/A ILE 173.A N PHE 162.A O no hydrogen 2.885 N/A LYS 176.A N GLY 172.A O no hydrogen 3.020 N/A PHE 177.A N PHE 174.A O no hydrogen 3.438 N/A LEU 178.A N PHE 174.A O no hydrogen 3.007 N/A LYS 179.A N MET 175.A O no hydrogen 3.090 N/A LYS 179.A NZ GLU 31.A OE1 no hydrogen 3.229 N/A LYS 179.A NZ GLU 31.A OE2 no hydrogen 3.227 N/A LYS 179.A NZ ASN 171.A OD1 no hydrogen 2.770 N/A ASP 180.A N PHE 177.A O no hydrogen 3.089 N/A ARG 181.A N LEU 178.A O no hydrogen 3.154 N/A ARG 181.A NE ASP 198.A OD2 no hydrogen 2.932 N/A ARG 181.A NH1 GLU 184.A OE2 no hydrogen 2.928 N/A ARG 181.A NH2 ASP 198.A OD1 no hydrogen 3.198 N/A ARG 181.A NH2 ASP 198.A OD2 no hydrogen 3.536 N/A LEU 182.A N LEU 178.A O no hydrogen 2.938 N/A GLU 184.A N ARG 181.A O no hydrogen 3.008 N/A LYS 186.A NZ GLU 194.A OE2 no hydrogen 2.712 N/A LYS 187.A NZ LEU 217.A O no hydrogen 3.336 N/A ILE 188.A N ARG 221.A O no hydrogen 2.952 N/A LEU 191.A N LYS 187.A O no hydrogen 2.956 N/A LEU 192.A N ILE 188.A O no hydrogen 3.100 N/A ASP 193.A N THR 189.A O no hydrogen 3.042 N/A GLU 194.A N VAL 190.A O no hydrogen 3.006 N/A VAL 195.A N LEU 191.A O no hydrogen 3.157 N/A ALA 196.A N LEU 192.A O no hydrogen 3.033 N/A GLU 197.A N ASP 193.A O no hydrogen 3.336 N/A ASP 198.A N GLU 194.A O no hydrogen 3.030 N/A MET 199.A N VAL 195.A O no hydrogen 3.055 N/A GLY 200.A N ALA 196.A O no hydrogen 3.077 N/A LYS 201.A N ASP 198.A O no hydrogen 3.056 N/A CYS 202.A N MET 199.A O no hydrogen 3.091 N/A LYS 206.A NZ MET 199.A O no hydrogen 3.387 N/A LYS 206.A NZ CYS 202.A O no hydrogen 2.786 N/A LYS 206.A NZ THR 205.A O no hydrogen 3.492 N/A LYS 208.A NZ LEU 204.A O no hydrogen 2.793 N/A GLN 209.A NE2 ALA 154.A O no hydrogen 3.052 N/A GLU 212.A N TYR 153.A O no hydrogen 3.101 N/A ARG 214.A N PHE 151.A O no hydrogen 2.985 N/A ARG 214.A NE GLU 212.A OE1 no hydrogen 3.397 N/A SER 216.A N ILE 149.A O no hydrogen 2.889 N/A SER 216.A OG ILE 149.A O no hydrogen 3.535 N/A SER 218.A N ALA 147.A O no hydrogen 3.303 N/A SER 218.A OG ALA 147.A O no hydrogen 3.423 N/A SER 218.A OG GLU 219.A OE2 no hydrogen 3.273 N/A ARG 221.A N GLU 219.A O no hydrogen 2.917 N/A ARG 221.A NE GLU 219.A OE1 no hydrogen 3.192 N/A ARG 221.A NH1 LEU 2.A O no hydrogen 3.389 N/A ARG 221.A NH1 TYR 70.A OH no hydrogen 2.625 N/A ALA 222.A N ASP 225.A OD2 no hydrogen 3.179 N/A THR 224.A OG1 ASP 185.A OD1 no hydrogen 2.624 N/A ASP 225.A N ALA 222.A O no hydrogen 3.051 N/A GLN 228.A N ALA 3.A O no hydrogen 3.374 N/A ARG 231.A NE LEU 64.A O no hydrogen 2.846 N/A ARG 231.A NH1 ASP 5.A OD2 no hydrogen 3.117 N/A ARG 231.A NH2 LEU 64.A O no hydrogen 3.024 N/A GLN 234.A N VAL 230.A O no hydrogen 3.198 N/A TRP 235.A N ARG 231.A O no hydrogen 3.088 N/A ALA 236.A N ASN 232.A O no hydrogen 2.976 N/A LYS 237.A N LEU 233.A O no hydrogen 3.261 N/A HIS 239.A N ALA 236.A O no hydrogen 3.160 N/A HIS 239.A ND1 TRP 235.A O no hydrogen 2.936 N/A SER 244.A OG GLN 256.A OE1 no hydrogen 2.612 N/A SER 244.A OG LEU 257.A O no hydrogen 3.133 N/A MET 245.A N LEU 257.A O no hydrogen 3.272 N/A CYS 246.A SG MET 245.A O no hydrogen 3.769 N/A CYS 246.A SG ILE 255.A O no hydrogen 4.018 N/A LEU 247.A N ILE 255.A O no hydrogen 2.883 N/A LYS 248.A NZ CYS 246.A O no hydrogen 3.237 N/A PHE 249.A N VAL 253.A O no hydrogen 2.864 N/A GLY 252.A N PHE 249.A O no hydrogen 2.964 N/A GLN 254.A N TYR 275.A O no hydrogen 3.173 N/A ILE 255.A N LEU 247.A O no hydrogen 3.031 N/A GLN 256.A N SER 272.A O no hydrogen 2.824 N/A LEU 257.A N MET 245.A O no hydrogen 3.271 N/A GLY 258.A N TYR 270.A O no hydrogen 3.047 N/A ALA 260.A N ILE 268.A O no hydrogen 2.874 N/A GLU 262.A N VAL 266.A O no hydrogen 3.003 N/A PHE 263.A N VAL 266.A O no hydrogen 3.089 N/A SER 264.A N SER 45.A O no hydrogen 2.843 N/A ASN 265.A ND2 LEU 47.A O no hydrogen 2.877 N/A ASN 265.A ND2 GLN 326.A OE1 no hydrogen 2.880 N/A VAL 266.A N PHE 263.A O no hydrogen 3.125 N/A MET 267.A N LEU 322.A O no hydrogen 3.181 N/A ILE 268.A N ALA 260.A O no hydrogen 2.899 N/A ILE 269.A N THR 320.A O no hydrogen 2.898 N/A TYR 270.A N GLY 258.A O no hydrogen 2.992 N/A THR 271.A N LEU 318.A O no hydrogen 3.162 N/A SER 272.A N GLN 256.A O no hydrogen 3.017 N/A SER 272.A OG LYS 315.A O no hydrogen 3.318 N/A VAL 274.A N GLN 254.A O no hydrogen 2.899 N/A TYR 275.A N GLN 254.A O no hydrogen 3.099 N/A GLU 279.A N GLU 279.A OE1 no hydrogen 2.842 N/A ILE 280.A N PRO 277.A O no hydrogen 3.178 N/A ILE 281.A N GLN 341.A O no hydrogen 3.155 N/A ASP 284.A N SER 339.A O no hydrogen 3.060 N/A TYR 286.A N CYS 337.A O no hydrogen 3.172 N/A THR 288.A N THR 335.A O no hydrogen 2.769 N/A LEU 294.A N PRO 291.A O no hydrogen 3.295 N/A ASP 300.A N ASP 297.A O no hydrogen 2.973 N/A ALA 301.A N PRO 298.A O no hydrogen 3.400 N/A ASN 302.A N THR 320.A OG1 no hydrogen 3.303 N/A ASN 302.A ND2 VAL 287.A O no hydrogen 3.390 N/A LYS 303.A N TYR 319.A O no hydrogen 2.917 N/A LYS 303.A NZ LYS 299.A O no hydrogen 2.756 N/A THR 305.A OG1 GLU 308.A OE2 no hydrogen 3.185 N/A GLU 308.A N THR 305.A O no hydrogen 3.344 N/A THR 309.A N PRO 306.A O no hydrogen 3.160 N/A THR 309.A OG1 PRO 306.A O no hydrogen 2.376 N/A GLY 310.A N GLU 307.A O no hydrogen 3.434 N/A SER 311.A N PRO 306.A O no hydrogen 3.155 N/A SER 311.A OG GLU 262.A OE1 no hydrogen 2.786 N/A TYR 312.A N GLU 262.A OE1 no hydrogen 2.846 N/A LEU 313.A N SER 311.A OG no hydrogen 3.205 N/A CYS 317.A SG TYR 319.A OH no hydrogen 3.501 N/A LEU 318.A N THR 271.A O no hydrogen 3.298 N/A TYR 319.A N LYS 303.A O no hydrogen 2.834 N/A THR 320.A N ILE 269.A O no hydrogen 2.987 N/A ARG 321.A NE GLU 262.A OE2 no hydrogen 3.194 N/A ARG 321.A NH2 GLU 262.A OE2 no hydrogen 3.222 N/A LEU 322.A N MET 267.A O no hydrogen 2.816 N/A LEU 325.A N ASN 265.A O no hydrogen 3.126 N/A GLN 326.A N GLN 326.A OE1 no hydrogen 2.901 N/A GLN 326.A NE2 GLU 53.A OE1 no hydrogen 2.658 N/A LYS 327.A N SER 324.A O no hydrogen 2.881 N/A LYS 327.A NZ GLU 53.A OE2 no hydrogen 3.448 N/A LEU 328.A N LEU 325.A O no hydrogen 3.252 N/A LYS 329.A N ASP 293.A OD2 no hydrogen 3.290 N/A LEU 332.A N GLY 358.A O no hydrogen 2.686 N/A PHE 334.A N VAL 355.A O no hydrogen 3.150 N/A THR 335.A N THR 288.A O no hydrogen 2.889 N/A VAL 336.A N GLN 353.A O no hydrogen 2.902 N/A CYS 337.A N TYR 286.A O no hydrogen 3.013 N/A SER 339.A N ASP 284.A O no hydrogen 3.444 N/A TYR 340.A N VAL 349.A O no hydrogen 3.194 N/A GLN 341.A N MET 282.A O no hydrogen 2.882 N/A GLN 341.A NE2 LEU 345.A O no hydrogen 3.350 N/A SER 343.A N GLU 279.A O no hydrogen 2.965 N/A SER 343.A OG GLU 279.A O no hydrogen 3.511 N/A VAL 349.A N TYR 340.A O no hydrogen 2.795 N/A ASP 351.A N LEU 338.A O no hydrogen 3.046 N/A GLN 353.A NE2 LYS 248.A O no hydrogen 3.680 N/A VAL 355.A N PHE 334.A O no hydrogen 2.855 N/A VAL 357.A N LEU 332.A O no hydrogen 2.884 N/A LYS 359.A NZ LYS 329.A O no hydrogen 3.119 N/A LYS 359.A NZ GLU 330.A O no hydrogen 3.122 N/A LEU 361.A N GLU 240.A O no hydrogen 2.952 N/A ILE 362.A N SER 264.A O no hydrogen 3.206 N/A ALA 363.A N PRO 360.A O no hydrogen 3.077 N/A LEU 365.A N ILE 362.A O no hydrogen 3.052 N/A