Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8x23_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ARG 5.A NE GLU 20.A OE2 no hydrogen 2.780 N/A ARG 5.A NH2 GLU 20.A OE2 no hydrogen 3.291 N/A LYS 6.A N PRO 93.A O no hydrogen 2.867 N/A LYS 6.A NZ THR 92.A O no hydrogen 2.813 N/A LYS 6.A NZ ALA 94.A O no hydrogen 2.724 N/A PHE 9.A N LYS 6.A O no hydrogen 3.307 N/A TYR 10.A N LEU 21.A O no hydrogen 2.840 N/A TYR 10.A OH TYR 25.A O no hydrogen 2.615 N/A GLN 12.A N TRP 19.A O no hydrogen 2.952 N/A VAL 14.A N THR 17.A O no hydrogen 2.761 N/A THR 17.A N VAL 14.A O no hydrogen 3.030 N/A THR 17.A OG1 VAL 14.A O no hydrogen 2.799 N/A TRP 19.A N GLN 12.A O no hydrogen 2.765 N/A GLU 20.A N TYR 104.A OH no hydrogen 2.892 N/A LEU 21.A N TYR 10.A O no hydrogen 2.929 N/A LYS 23.A N GLY 8.A O no hydrogen 2.769 N/A THR 24.A OG1 ASP 44.A OD1 no hydrogen 3.060 N/A TYR 25.A N PRO 22.A O no hydrogen 3.075 N/A TYR 25.A OH ASP 89.A OD2 no hydrogen 2.778 N/A VAL 26.A N ILE 43.A O no hydrogen 2.875 N/A THR 29.A N SER 41.A O no hydrogen 2.803 N/A THR 29.A OG1 SER 27.A O no hydrogen 3.020 N/A VAL 31.A N VAL 39.A O no hydrogen 2.931 N/A GLY 32.A N VAL 39.A O no hydrogen 3.143 N/A GLY 34.A N GLY 37.A O no hydrogen 2.860 N/A SER 38.A N LYS 55.A O no hydrogen 3.018 N/A VAL 39.A N GLY 32.A O no hydrogen 2.784 N/A CYS 40.A N ILE 53.A O no hydrogen 2.861 N/A CYS 40.A SG SER 41.A O no hydrogen 3.646 N/A SER 41.A N THR 29.A O no hydrogen 2.770 N/A ALA 42.A N VAL 51.A O no hydrogen 2.935 N/A ILE 43.A N VAL 26.A O no hydrogen 2.849 N/A ASP 44.A N GLU 49.A O no hydrogen 2.874 N/A LYS 45.A N THR 24.A O no hydrogen 2.826 N/A ARG 46.A N ASP 44.A OD1 no hydrogen 3.048 N/A ARG 46.A NE ASP 44.A OD1 no hydrogen 2.866 N/A ARG 46.A NE ASP 44.A OD2 no hydrogen 3.272 N/A ARG 46.A NH2 ASP 44.A OD2 no hydrogen 2.728 N/A SER 47.A N ASP 44.A O no hydrogen 3.067 N/A SER 47.A OG ASP 44.A O no hydrogen 3.563 N/A GLY 48.A N ASP 44.A O no hydrogen 2.713 N/A GLU 49.A N SER 47.A OG no hydrogen 3.264 N/A VAL 51.A N ALA 42.A O no hydrogen 2.781 N/A ALA 52.A N MET 107.A O no hydrogen 2.811 N/A ILE 53.A N CYS 40.A O no hydrogen 2.820 N/A LYS 54.A N LEU 105.A O no hydrogen 2.800 N/A LYS 55.A N SER 38.A O no hydrogen 2.824 N/A LYS 55.A NZ ALA 18.A O no hydrogen 2.863 N/A LEU 56.A N PHE 103.A O no hydrogen 2.950 N/A SER 57.A N TYR 36.A O no hydrogen 2.904 N/A GLN 61.A N ARG 58.A O no hydrogen 3.184 N/A GLN 61.A NE2 ARG 58.A O no hydrogen 2.856 N/A PHE 65.A N SER 62.A OG no hydrogen 3.092 N/A ALA 66.A N SER 62.A O no hydrogen 2.971 N/A LYS 67.A N GLU 63.A O no hydrogen 2.911 N/A LYS 67.A NZ GLU 323.A O no hydrogen 2.889 N/A LYS 67.A NZ GLU 325.A O no hydrogen 2.964 N/A ARG 68.A N ILE 64.A O no hydrogen 3.078 N/A ARG 68.A NH2 ASP 168.A OD1.B no hydrogen 2.827 N/A ALA 69.A N PHE 65.A O no hydrogen 3.013 N/A TYR 70.A N ALA 66.A O no hydrogen 3.040 N/A ARG 71.A N LYS 67.A O no hydrogen 2.928 N/A ARG 71.A NE GLY 170.A O no hydrogen 2.697 N/A ARG 71.A NH2 GLY 170.A O no hydrogen 3.069 N/A GLU 72.A N ARG 68.A O no hydrogen 2.852 N/A LEU 73.A N ALA 69.A O no hydrogen 3.097 N/A LEU 74.A N TYR 70.A O no hydrogen 3.019 N/A LEU 75.A N ARG 71.A O no hydrogen 2.852 N/A LEU 76.A N GLU 72.A O no hydrogen 2.949 N/A LYS 77.A N LEU 73.A O no hydrogen 3.091 N/A LYS 77.A NZ.A GLU 339.A O no hydrogen 3.305 N/A LYS 77.A NZ.A GLU 339.A OE2 no hydrogen 2.480 N/A LYS 77.A NZ.B GLU 339.A O no hydrogen 3.189 N/A LYS 77.A NZ.B GLU 339.A OE2 no hydrogen 2.533 N/A HIS 78.A N LEU 74.A O no hydrogen 2.959 N/A HIS 78.A NE2 GLN 316.A O no hydrogen 2.886 N/A MET 79.A N LEU 75.A O no hydrogen 3.260 N/A GLN 80.A N TYR 140.A OH no hydrogen 2.974 N/A ASN 83.A N HIS 81.A ND1 no hydrogen 2.903 N/A ASN 83.A ND2 GLN 133.A OE1 no hydrogen 3.246 N/A ASN 83.A ND2 LEU 164.A O no hydrogen 2.937 N/A VAL 84.A N HIS 81.A O no hydrogen 3.079 N/A ILE 85.A N ILE 166.A O no hydrogen 2.988 N/A LEU 88.A N VAL 106.A O no hydrogen 2.728 N/A ASP 89.A N VAL 106.A O no hydrogen 3.361 N/A VAL 90.A N ASP 89.A OD1 no hydrogen 2.892 N/A PHE 91.A N TYR 104.A O no hydrogen 3.034 N/A THR 92.A OG1 ASP 102.A O no hydrogen 2.797 N/A ALA 94.A N THR 92.A OG1 no hydrogen 3.244 N/A SER 95.A N ASN 99.A OD1 no hydrogen 2.933 N/A SER 96.A N ASN 99.A OD1 no hydrogen 3.024 N/A ARG 98.A N SER 96.A OG no hydrogen 3.131 N/A ASN 99.A ND2 ILE 4.A O no hydrogen 3.450 N/A ASN 99.A ND2 SER 95.A OG no hydrogen 2.864 N/A PHE 100.A N LEU 97.A O no hydrogen 3.246 N/A TYR 104.A N PHE 91.A O no hydrogen 2.822 N/A LEU 105.A N LYS 54.A O no hydrogen 2.874 N/A VAL 106.A N ASP 89.A O no hydrogen 2.839 N/A MET 107.A N ALA 52.A O no hydrogen 2.838 N/A THR 112.A N VAL 158.A O no hydrogen 2.898 N/A ASP 113.A N THR 112.A OG1 no hydrogen 2.752 N/A LEU 114.A N LEU 156.A O no hydrogen 2.894 N/A LYS 116.A N ASP 113.A OD1 no hydrogen 3.092 N/A ILE 117.A N LEU 114.A O no hydrogen 3.219 N/A PHE 122.A N MET 210.A O no hydrogen 2.968 N/A LYS 126.A N SER 123.A OG no hydrogen 2.980 N/A ILE 127.A N SER 123.A O no hydrogen 3.079 N/A GLN 128.A N GLU 124.A O no hydrogen 2.768 N/A GLN 128.A NE2 PHE 301.A O no hydrogen 2.699 N/A TYR 129.A N GLU 125.A O no hydrogen 2.990 N/A LEU 130.A N LYS 126.A O no hydrogen 2.956 N/A VAL 131.A N ILE 127.A O no hydrogen 2.869 N/A TYR 132.A N GLN 128.A O no hydrogen 2.901 N/A TYR 132.A OH GLU 311.A OE1 no hydrogen 2.645 N/A GLN 133.A N TYR 129.A O no hydrogen 3.204 N/A GLN 133.A NE2 TYR 129.A O no hydrogen 3.234 N/A GLN 133.A NE2 CYS 162.A O no hydrogen 2.848 N/A MET 134.A N LEU 130.A O no hydrogen 3.027 N/A LEU 135.A N VAL 131.A O no hydrogen 2.953 N/A LYS 136.A N TYR 132.A O no hydrogen 2.969 N/A LYS 136.A NZ GLU 310.A OE2 no hydrogen 2.759 N/A GLY 137.A N GLN 133.A O no hydrogen 3.064 N/A LEU 138.A N MET 134.A O no hydrogen 2.968 N/A LYS 139.A N LEU 135.A O no hydrogen 2.803 N/A LYS 139.A NZ GLU 311.A O no hydrogen 2.823 N/A TYR 140.A N LYS 136.A O no hydrogen 3.075 N/A ILE 141.A N GLY 137.A O no hydrogen 3.025 N/A HIS 142.A N LEU 138.A O no hydrogen 2.805 N/A HIS 142.A NE2 ASP 199.A OD2 no hydrogen 2.826 N/A SER 143.A N LYS 139.A O no hydrogen 2.925 N/A SER 143.A OG LYS 139.A O no hydrogen 3.447 N/A SER 143.A OG TYR 140.A O no hydrogen 2.583 N/A ALA 144.A N TYR 140.A O no hydrogen 3.262 N/A ALA 144.A N ILE 141.A O no hydrogen 2.942 N/A GLY 145.A N HIS 142.A O no hydrogen 2.883 N/A VAL 146.A N ILE 141.A O no hydrogen 2.997 N/A HIS 148.A N ASP 199.A OD2 no hydrogen 2.824 N/A HIS 148.A NE2 LEU 167.A O no hydrogen 2.803 N/A ARG 149.A N ASP 199.A OD1 no hydrogen 2.730 N/A ARG 149.A NH1 ARG 173.A O no hydrogen 3.417 N/A ASP 150.A N HIS 148.A ND1 no hydrogen 3.028 N/A LYS 152.A N ASN 155.A OD1 no hydrogen 2.883 N/A LYS 152.A NZ ASP 150.A OD2 no hydrogen 3.420 N/A ASN 155.A N LYS 152.A O no hydrogen 2.997 N/A ASN 155.A ND2 ASP 150.A O no hydrogen 2.779 N/A LEU 156.A N PRO 153.A O no hydrogen 3.113 N/A ALA 157.A N LYS 165.A O no hydrogen 2.887 N/A VAL 158.A N THR 112.A O no hydrogen 2.937 N/A ASN 159.A N GLU 163.A O no hydrogen 3.004 N/A ASN 159.A ND2 GLU 163.A OE1 no hydrogen 2.877 N/A CYS 162.A N ASN 159.A O no hydrogen 2.966 N/A GLU 163.A N ASN 159.A OD1 no hydrogen 2.889 N/A LEU 164.A N GLN 133.A OE1 no hydrogen 2.951 N/A LYS 165.A N ALA 157.A O no hydrogen 2.879 N/A LYS 165.A NZ GLU 82.A O no hydrogen 2.780 N/A ILE 166.A N ASN 83.A O no hydrogen 2.867 N/A LEU 167.A N ASN 155.A O no hydrogen 2.808 N/A THR 174.A OG1 TYR 176.A O no hydrogen 2.453 N/A TYR 176.A N THR 174.A OG1 no hydrogen 3.244 N/A TYR 182.A OH GLU 209.A OE1 no hydrogen 2.609 N/A ARG 183.A N ARG 180.A O no hydrogen 3.089 N/A ARG 183.A NE ASP 150.A OD1 no hydrogen 3.230 N/A GLU 186.A N GLU 186.A OE1 no hydrogen 2.841 N/A VAL 187.A N ALA 184.A O no hydrogen 2.963 N/A ILE 188.A N ALA 184.A O no hydrogen 3.131 N/A LEU 189.A N PRO 185.A O no hydrogen 2.889 N/A SER 190.A OG LEU 189.A O no hydrogen 2.914 N/A ASN 195.A ND2 VAL 287.A O no hydrogen 2.902 N/A GLN 196.A NE2 HIS 142.A O no hydrogen 2.885 N/A THR 197.A N ASN 195.A OD1 no hydrogen 2.940 N/A THR 197.A OG1 ASN 195.A OD1 no hydrogen 2.678 N/A THR 197.A OG1 VAL 287.A O no hydrogen 3.327 N/A VAL 198.A N ASN 195.A O no hydrogen 3.197 N/A ASP 199.A N GLN 196.A O no hydrogen 3.323 N/A ILE 200.A N THR 197.A O no hydrogen 2.914 N/A TRP 201.A N THR 197.A O no hydrogen 3.281 N/A SER 202.A OG TYR 182.A O no hydrogen 2.676 N/A VAL 203.A N ASP 199.A O no hydrogen 3.013 N/A GLY 204.A N ILE 200.A O no hydrogen 2.943 N/A CYS 205.A N TRP 201.A O no hydrogen 2.962 N/A CYS 205.A SG TRP 181.A O no hydrogen 3.914 N/A CYS 205.A SG TRP 201.A O no hydrogen 3.509 N/A ILE 206.A N SER 202.A O no hydrogen 2.935 N/A MET 207.A N VAL 203.A O no hydrogen 2.826 N/A ALA 208.A N GLY 204.A O no hydrogen 2.903 N/A GLU 209.A N CYS 205.A O no hydrogen 3.169 N/A MET 210.A N ILE 206.A O no hydrogen 2.971 N/A LEU 211.A N MET 207.A O no hydrogen 2.968 N/A THR 212.A N ALA 208.A O no hydrogen 2.978 N/A THR 212.A OG1 ALA 208.A O no hydrogen 3.125 N/A GLY 213.A N GLU 209.A O no hydrogen 2.720 N/A LYS 214.A N THR 212.A OG1 no hydrogen 2.978 N/A THR 215.A OG1 GLU 209.A OE2 no hydrogen 3.478 N/A LYS 218.A N GLN 228.A OE1 no hydrogen 2.888 N/A LYS 220.A N ASP 224.A OD2 no hydrogen 2.773 N/A ASP 224.A N ASP 221.A OD1 no hydrogen 2.983 N/A GLN 225.A N ASP 221.A O no hydrogen 2.969 N/A GLN 225.A NE2 ARG 180.A O no hydrogen 2.866 N/A LEU 226.A N TYR 222.A O no hydrogen 2.895 N/A THR 227.A N LEU 223.A O no hydrogen 2.934 N/A THR 227.A OG1 LEU 223.A O no hydrogen 2.965 N/A GLN 228.A N ASP 224.A O no hydrogen 3.054 N/A GLN 228.A NE2 ASP 224.A OD1 no hydrogen 3.369 N/A ILE 229.A N GLN 225.A O no hydrogen 2.854 N/A LEU 230.A N LEU 226.A O no hydrogen 2.836 N/A LYS 231.A N THR 227.A O no hydrogen 3.159 N/A VAL 232.A N ILE 229.A O no hydrogen 2.933 N/A THR 233.A N ILE 229.A O no hydrogen 2.877 N/A THR 233.A OG1 ILE 229.A O no hydrogen 3.306 N/A THR 233.A OG1 GLY 234.A O no hydrogen 2.881 N/A GLY 234.A N LEU 230.A O no hydrogen 2.813 N/A VAL 235.A N THR 259.A O no hydrogen 2.850 N/A PHE 240.A N GLY 237.A O no hydrogen 3.172 N/A VAL 241.A N GLY 237.A O no hydrogen 2.989 N/A GLN 242.A N THR 238.A O no hydrogen 3.221 N/A LYS 243.A N PHE 240.A O no hydrogen 2.869 N/A LYS 243.A NZ ASP 286.A OD1 no hydrogen 3.208 N/A LYS 243.A NZ ASP 286.A OD2 no hydrogen 2.731 N/A LEU 244.A N VAL 241.A O no hydrogen 3.193 N/A ASN 245.A N TRP 191.A O no hydrogen 2.789 N/A ALA 249.A N ASP 246.A OD1 no hydrogen 3.018 N/A LYS 250.A N ASP 246.A O no hydrogen 2.969 N/A SER 251.A N LYS 247.A O no hydrogen 2.955 N/A TYR 252.A N ALA 248.A O no hydrogen 2.957 N/A ILE 253.A N ALA 249.A O no hydrogen 2.961 N/A GLN 254.A N LYS 250.A O no hydrogen 2.904 N/A SER 255.A N TYR 252.A O no hydrogen 3.130 N/A SER 255.A OG SER 251.A O no hydrogen 2.705 N/A LEU 256.A N ILE 253.A O no hydrogen 3.224 N/A GLN 258.A NE2 ILE 253.A O no hydrogen 2.844 N/A GLN 258.A NE2 LEU 256.A O no hydrogen 2.869 N/A THR 259.A N PRO 257.A O no hydrogen 2.964 N/A THR 259.A OG1 PRO 257.A O no hydrogen 3.499 N/A ARG 261.A NE GLU 280.A OE2 no hydrogen 2.772 N/A ARG 261.A NH1 THR 233.A O no hydrogen 2.968 N/A ARG 261.A NH2 GLU 280.A OE2 no hydrogen 3.138 N/A ARG 261.A NH2 LEU 283.A O no hydrogen 2.898 N/A LYS 262.A NZ LYS 231.A O no hydrogen 2.536 N/A THR 265.A N ASP 263.A OD1 no hydrogen 3.204 N/A THR 265.A OG1 ASP 263.A OD1 no hydrogen 2.961 N/A THR 265.A OG1 ASP 263.A OD2 no hydrogen 3.242 N/A GLN 266.A N ASP 263.A O no hydrogen 2.915 N/A LEU 267.A N ASP 263.A O no hydrogen 2.901 N/A PHE 268.A N PHE 264.A O no hydrogen 2.762 N/A ALA 271.A N PHE 268.A O no hydrogen 3.017 N/A SER 272.A N GLU 124.A OE2 no hydrogen 2.864 N/A SER 272.A OG GLU 124.A OE1 no hydrogen 2.806 N/A ALA 275.A N SER 272.A OG no hydrogen 3.030 N/A ALA 276.A N SER 272.A O no hydrogen 2.978 N/A ASP 277.A N PRO 273.A O no hydrogen 2.912 N/A LEU 278.A N GLN 274.A O no hydrogen 3.019 N/A LEU 279.A N ALA 275.A O no hydrogen 3.000 N/A GLU 280.A N ALA 276.A O no hydrogen 2.931 N/A LYS 281.A N ASP 277.A O no hydrogen 3.188 N/A LYS 281.A N LEU 278.A O no hydrogen 3.034 N/A LYS 281.A NZ ASP 277.A OD2 no hydrogen 2.814 N/A MET 282.A N LEU 278.A O no hydrogen 2.993 N/A MET 282.A N LEU 279.A O no hydrogen 3.220 N/A LEU 283.A N LEU 279.A O no hydrogen 2.830 N/A ASP 286.A N GLU 284.A OE2 no hydrogen 2.923 N/A ASP 288.A N ASP 286.A OD1 no hydrogen 2.896 N/A LYS 289.A N ASP 286.A O no hydrogen 3.083 N/A LYS 289.A NZ GLU 239.A OE1 no hydrogen 2.782 N/A ARG 290.A N ASP 286.A O no hydrogen 2.940 N/A ARG 290.A NE GLU 284.A O no hydrogen 2.749 N/A ARG 290.A NH1 GLU 186.A OE2 no hydrogen 2.782 N/A ARG 290.A NH1 THR 197.A O no hydrogen 3.013 N/A ARG 290.A NH2 GLU 186.A OE1 no hydrogen 2.921 N/A ARG 290.A NH2 GLU 186.A OE2 no hydrogen 3.539 N/A ARG 290.A NH2 GLU 284.A O no hydrogen 2.866 N/A LEU 291.A N LYS 281.A O no hydrogen 3.245 N/A THR 292.A N GLN 295.A OE1 no hydrogen 3.016 N/A GLN 295.A N THR 292.A OG1 no hydrogen 3.094 N/A ALA 296.A N THR 292.A O no hydrogen 2.937 N/A LEU 297.A N ALA 293.A O no hydrogen 3.010 N/A THR 298.A N GLN 295.A O no hydrogen 3.041 N/A THR 298.A OG1 GLN 295.A O no hydrogen 2.669 N/A HIS 299.A N ALA 296.A O no hydrogen 2.996 N/A HIS 299.A NE2 ASP 277.A OD2 no hydrogen 2.735 N/A PHE 301.A N HIS 299.A ND1 no hydrogen 2.994 N/A PHE 302.A N HIS 299.A O no hydrogen 3.012 N/A GLU 303.A N PRO 300.A O no hydrogen 2.977 N/A PHE 305.A N PHE 302.A O no hydrogen 2.933 N/A ARG 306.A NE GLU 311.A OE1 no hydrogen 2.917 N/A ARG 306.A NH2 GLU 311.A OE2 no hydrogen 2.913 N/A ASP 307.A N TYR 132.A OH no hydrogen 2.879 N/A GLU 309.A N ASP 307.A OD1 no hydrogen 3.184 N/A GLU 310.A N ASP 307.A O no hydrogen 2.836 N/A GLU 311.A N PRO 308.A O no hydrogen 3.072 N/A ALA 314.A N SER 143.A OG no hydrogen 2.744 N/A GLN 316.A NE2 GLN 315.A OE1 no hydrogen 3.073 N/A PHE 318.A N ALA 144.A O no hydrogen 2.830 N/A LEU 322.A N ASP 320.A OD1 no hydrogen 2.938 N/A GLU 323.A N ASP 320.A O no hydrogen 3.109 N/A GLU 325.A N LEU 322.A O no hydrogen 3.164 N/A LYS 326.A NZ GLU 63.A OE1 no hydrogen 2.747 N/A THR 328.A N GLU 331.A OE1 no hydrogen 2.764 N/A THR 328.A OG1 GLU 331.A OE1 no hydrogen 3.133 N/A GLU 331.A N THR 328.A OG1 no hydrogen 3.065 N/A TRP 332.A N THR 328.A O no hydrogen 2.998 N/A LYS 333.A N VAL 329.A O no hydrogen 2.803 N/A LYS 333.A NZ ASP 330.A OD1 no hydrogen 3.281 N/A GLN 334.A N ASP 330.A O no hydrogen 2.944 N/A GLN 334.A NE2 ASP 330.A OD2 no hydrogen 2.657 N/A HIS 335.A N GLU 331.A O no hydrogen 3.049 N/A ILE 336.A N TRP 332.A O no hydrogen 2.982 N/A TYR 337.A N LYS 333.A O no hydrogen 2.912 N/A LYS 338.A N GLN 334.A O no hydrogen 3.111 N/A GLU 339.A N HIS 335.A O no hydrogen 2.966 N/A ILE 340.A N ILE 336.A O no hydrogen 2.994 N/A VAL 341.A N TYR 337.A O no hydrogen 3.100 N/A ASN 342.A N LYS 338.A O no hydrogen 2.887 N/A PHE 343.A N ILE 340.A O no hydrogen 3.050 N/A