Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8x5z_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): GLU 3.A N GLU 3.A OE1 no hydrogen 2.806 N/A ILE 5.A N SER 1.A O no hydrogen 3.034 N/A LEU 6.A N ASP 2.A O no hydrogen 3.149 N/A GLU 7.A N GLU 3.A O no hydrogen 2.843 N/A LYS 8.A N GLU 4.A O no hydrogen 2.970 N/A LEU 9.A N ILE 5.A O no hydrogen 2.927 N/A ARG 10.A N LEU 6.A O no hydrogen 2.840 N/A ARG 10.A NE GLU 7.A OE1 no hydrogen 3.057 N/A ARG 10.A NH2 GLU 7.A OE2 no hydrogen 2.944 N/A SER 11.A N GLU 7.A O no hydrogen 3.113 N/A SER 11.A OG LYS 8.A O no hydrogen 2.600 N/A ILE 12.A N LYS 8.A O no hydrogen 3.233 N/A ILE 12.A N LEU 9.A O no hydrogen 2.980 N/A VAL 13.A N LEU 9.A O no hydrogen 3.048 N/A SER 14.A N SER 82.A O no hydrogen 2.962 N/A SER 14.A OG ASP 81.A OD1 no hydrogen 2.468 N/A SER 14.A OG ASP 81.A OD2 no hydrogen 3.467 N/A LYS 19.A N ASP 17.A OD1 no hydrogen 2.881 N/A LYS 21.A NZ ASP 81.A OD2 no hydrogen 3.343 N/A TYR 22.A N PRO 18.A O no hydrogen 3.263 N/A THR 23.A N MET 37.A O no hydrogen 2.920 N/A GLU 26.A N THR 35.A O no hydrogen 2.817 N/A ILE 28.A N VAL 33.A O no hydrogen 2.802 N/A THR 32.A N GLN 49.A O no hydrogen 2.893 N/A VAL 33.A N GLY 29.A O no hydrogen 3.060 N/A TYR 34.A N ILE 47.A O no hydrogen 2.732 N/A THR 35.A N GLU 26.A O no hydrogen 2.818 N/A ALA 36.A N VAL 45.A O no hydrogen 2.990 N/A MET 37.A N THR 23.A O no hydrogen 2.805 N/A ASP 38.A N GLN 43.A O no hydrogen 2.814 N/A VAL 39.A N LYS 21.A O no hydrogen 2.934 N/A ALA 40.A N ASP 38.A OD1 no hydrogen 2.721 N/A THR 41.A N ASP 38.A OD1 no hydrogen 2.822 N/A GLY 42.A N ASP 38.A O no hydrogen 2.946 N/A GLN 43.A N THR 41.A OG1 no hydrogen 3.225 N/A VAL 45.A N ALA 36.A O no hydrogen 2.809 N/A ALA 46.A N MET 93.A O no hydrogen 2.907 N/A ILE 47.A N TYR 34.A O no hydrogen 2.731 N/A ARG 48.A N VAL 91.A O no hydrogen 2.992 N/A ARG 48.A NH2 GLU 64.A OE1 no hydrogen 3.385 N/A ARG 48.A NH2 GLU 64.A OE2 no hydrogen 3.089 N/A GLN 49.A N THR 32.A O no hydrogen 2.723 N/A MET 50.A N LEU 89.A O no hydrogen 2.803 N/A LEU 52.A N ASP 87.A O no hydrogen 2.782 N/A GLN 53.A N ASN 51.A OD1 no hydrogen 3.032 N/A GLN 53.A NE2 ASP 87.A OD2 no hydrogen 2.957 N/A GLN 54.A N ASN 51.A O no hydrogen 3.017 N/A GLN 55.A N LEU 52.A O no hydrogen 3.199 N/A LYS 58.A NZ LEU 52.A O no hydrogen 2.926 N/A LYS 58.A NZ GLN 55.A O no hydrogen 3.092 N/A LEU 60.A N LYS 57.A O no hydrogen 3.115 N/A ILE 61.A N LYS 58.A O no hydrogen 2.942 N/A ILE 62.A N LYS 58.A O no hydrogen 3.105 N/A ASN 63.A N GLU 59.A O no hydrogen 2.993 N/A GLU 64.A N LEU 60.A O no hydrogen 2.816 N/A ILE 65.A N ILE 61.A O no hydrogen 3.040 N/A LEU 66.A N ILE 62.A O no hydrogen 3.008 N/A VAL 67.A N ASN 63.A O no hydrogen 2.894 N/A MET 68.A N GLU 64.A O no hydrogen 2.997 N/A ARG 69.A N ILE 65.A O no hydrogen 2.845 N/A ARG 69.A NE GLU 70.A OE2 no hydrogen 2.945 N/A ARG 69.A NH2 GLU 70.A OE2 no hydrogen 3.366 N/A GLU 70.A N LEU 66.A O no hydrogen 3.164 N/A GLU 70.A N VAL 67.A O no hydrogen 3.275 N/A ASN 71.A N MET 68.A O no hydrogen 3.362 N/A ASN 71.A ND2 VAL 67.A O no hydrogen 2.911 N/A LYS 72.A NZ ASN 78.A OD1 no hydrogen 2.771 N/A LYS 72.A NZ TYR 79.A O no hydrogen 2.906 N/A ASN 75.A N ASN 73.A OD1 no hydrogen 2.998 N/A ASN 75.A ND2 GLU 121.A OE1 no hydrogen 2.843 N/A ASN 75.A ND2 VAL 152.A O no hydrogen 2.937 N/A ILE 76.A N ASN 73.A O no hydrogen 2.963 N/A VAL 77.A N LEU 154.A O no hydrogen 2.946 N/A ASN 78.A N GLU 94.A OE2 no hydrogen 2.826 N/A TYR 79.A OH SER 82.A OG no hydrogen 2.880 N/A LEU 80.A N VAL 92.A O no hydrogen 2.766 N/A ASP 81.A N VAL 92.A O no hydrogen 3.248 N/A SER 82.A N ASP 81.A OD1 no hydrogen 3.030 N/A SER 82.A OG TYR 79.A OH no hydrogen 2.880 N/A TYR 83.A N TRP 90.A O no hydrogen 2.992 N/A VAL 85.A N GLU 88.A O no hydrogen 2.820 N/A GLU 88.A N VAL 85.A O no hydrogen 3.020 N/A LEU 89.A N MET 50.A O no hydrogen 2.866 N/A TRP 90.A N TYR 83.A O no hydrogen 2.828 N/A TRP 90.A NE1 GLU 88.A OE1 no hydrogen 2.966 N/A VAL 91.A N ARG 48.A O no hydrogen 2.934 N/A VAL 92.A N ASP 81.A O no hydrogen 2.806 N/A MET 93.A N ALA 46.A O no hydrogen 2.914 N/A GLU 94.A N ASN 78.A O no hydrogen 2.885 N/A TYR 95.A N GLU 44.A O no hydrogen 3.305 N/A GLY 98.A N LEU 146.A O no hydrogen 2.809 N/A SER 100.A N ASP 103.A OD2 no hydrogen 3.175 N/A LEU 101.A N ILE 144.A O no hydrogen 2.838 N/A THR 102.A OG1 SER 141.A OG.A no hydrogen 2.480 N/A THR 102.A OG1 ASP 142.A OD1 no hydrogen 2.509 N/A VAL 104.A N SER 100.A O no hydrogen 3.434 N/A VAL 105.A N LEU 101.A O no hydrogen 2.865 N/A THR 106.A N THR 102.A O no hydrogen 2.983 N/A THR 106.A OG1 THR 102.A O no hydrogen 2.814 N/A THR 106.A OG1 ASP 103.A O no hydrogen 3.482 N/A GLU 107.A N ASP 103.A O no hydrogen 3.078 N/A GLU 107.A N VAL 104.A O no hydrogen 3.322 N/A THR 108.A N VAL 104.A O no hydrogen 2.886 N/A THR 108.A OG1 VAL 104.A O no hydrogen 2.653 N/A CYS 109.A SG.A MET 110.A O no hydrogen 4.049 N/A ASP 111.A N GLN 114.A OE1 no hydrogen 2.861 N/A GLN 114.A N ASP 111.A OD1 no hydrogen 2.876 N/A GLN 114.A NE2 SER 277.A O no hydrogen 3.047 N/A ILE 115.A N ASP 111.A O no hydrogen 2.883 N/A ALA 116.A N GLU 112.A O no hydrogen 2.809 N/A ALA 117.A N GLY 113.A O no hydrogen 3.258 N/A VAL 118.A N GLN 114.A O no hydrogen 3.140 N/A CYS 119.A N ILE 115.A O no hydrogen 2.878 N/A CYS 119.A SG ILE 115.A O no hydrogen 3.444 N/A ARG 120.A N ALA 116.A O no hydrogen 2.895 N/A ARG 120.A NE GLU 121.A OE2 no hydrogen 2.942 N/A ARG 120.A NH2 GLU 121.A OE2 no hydrogen 2.790 N/A GLU 121.A N ALA 117.A O no hydrogen 3.123 N/A CYS 122.A N VAL 118.A O no hydrogen 3.023 N/A CYS 122.A SG VAL 118.A O no hydrogen 3.370 N/A LEU 123.A N CYS 119.A O no hydrogen 2.880 N/A GLN 124.A N ARG 120.A O no hydrogen 2.933 N/A GLN 124.A NE2 ASN 75.A OD1 no hydrogen 2.891 N/A GLN 124.A NE2 GLU 121.A OE2 no hydrogen 3.281 N/A ALA 125.A N GLU 121.A O no hydrogen 3.266 N/A LEU 126.A N CYS 122.A O no hydrogen 3.006 N/A GLU 127.A N LEU 123.A O no hydrogen 2.793 N/A PHE 128.A N GLN 124.A O no hydrogen 3.233 N/A LEU 129.A N ALA 125.A O no hydrogen 2.946 N/A HIS 130.A N LEU 126.A O no hydrogen 2.759 N/A HIS 130.A NE2 ASP 194.A OD2 no hydrogen 2.897 N/A SER 131.A N GLU 127.A O no hydrogen 2.923 N/A SER 131.A OG GLU 127.A O no hydrogen 3.366 N/A SER 131.A OG PHE 128.A O no hydrogen 2.830 N/A ASN 132.A N PHE 128.A O no hydrogen 3.066 N/A ASN 132.A N LEU 129.A O no hydrogen 3.035 N/A ASN 132.A ND2 ASN 71.A OD1 no hydrogen 2.716 N/A GLN 133.A N HIS 130.A O no hydrogen 2.975 N/A VAL 134.A N LEU 129.A O no hydrogen 2.818 N/A ILE 135.A N ALA 161.A O no hydrogen 2.799 N/A HIS 136.A N ASP 194.A OD2 no hydrogen 2.803 N/A HIS 136.A NE2 THR 155.A O no hydrogen 2.818 N/A ARG 137.A N ASP 194.A OD1 no hydrogen 2.833 N/A ARG 137.A NE PHE 159.A O no hydrogen 2.697 N/A ARG 137.A NH1 TYR 189.A OH no hydrogen 2.790 N/A ARG 137.A NH2 PHE 159.A O no hydrogen 3.166 N/A ASP 138.A N HIS 136.A ND1 no hydrogen 3.025 N/A LYS 140.A NZ THR 175.A OG1 no hydrogen 2.834 N/A SER 141.A N GLU 204.A OE2 no hydrogen 3.374 N/A SER 141.A OG.A THR 102.A OG1 no hydrogen 2.480 N/A SER 141.A OG.A GLU 204.A OE1 no hydrogen 2.735 N/A SER 141.A OG.A GLU 204.A OE2 no hydrogen 3.397 N/A SER 141.A OG.B GLU 204.A OE2 no hydrogen 2.533 N/A ASN 143.A N LYS 140.A O no hydrogen 2.930 N/A ASN 143.A ND2 ASP 138.A O no hydrogen 2.881 N/A ILE 144.A N SER 141.A O no hydrogen 3.102 N/A LEU 145.A N LYS 153.A O no hydrogen 2.791 N/A LEU 146.A N GLY 99.A O no hydrogen 2.991 N/A GLY 147.A N SER 151.A O no hydrogen 2.976 N/A GLY 150.A N GLY 147.A O no hydrogen 3.029 N/A SER 151.A N ASP 149.A OD1 no hydrogen 2.991 N/A SER 151.A OG ASP 149.A OD1 no hydrogen 2.703 N/A SER 151.A OG ASP 149.A OD2 no hydrogen 3.281 N/A LYS 153.A N LEU 145.A O no hydrogen 2.972 N/A LYS 153.A NZ GLU 94.A OE1 no hydrogen 3.321 N/A LYS 153.A NZ GLU 94.A OE2 no hydrogen 2.940 N/A LEU 154.A N ASN 75.A O no hydrogen 2.783 N/A THR 155.A N ASN 143.A O no hydrogen 2.924 N/A ASP 156.A N THR 155.A OG1 no hydrogen 2.866 N/A GLY 158.A N ASP 156.A OD1 no hydrogen 2.930 N/A CYS 160.A SG PHE 157.A O no hydrogen 3.458 N/A ALA 161.A N ILE 135.A O no hydrogen 2.811 N/A GLN 162.A NE2 ASN 63.A OD1 no hydrogen 2.815 N/A ILE 163.A N GLN 133.A O no hydrogen 2.956 N/A THR 164.A N GLN 167.A O no hydrogen 3.198 N/A THR 164.A OG1 GLU 166.A OE1 no hydrogen 2.973 N/A THR 164.A OG1 GLN 167.A OE1 no hydrogen 3.072 N/A GLN 167.A N THR 164.A OG1 no hydrogen 3.121 N/A ARG 170.A N TYR 189.A O no hydrogen 2.836 N/A THR 175.A N ASP 138.A OD1 no hydrogen 2.947 N/A THR 175.A OG1 ASP 138.A OD1 no hydrogen 2.702 N/A THR 175.A OG1 ASP 138.A OD2 no hydrogen 3.421 N/A TYR 177.A OH GLU 215.A O no hydrogen 2.628 N/A TRP 178.A N THR 175.A O no hydrogen 2.967 N/A TRP 178.A NE1 GLU 204.A OE2 no hydrogen 2.708 N/A MET 179.A N PRO 176.A O no hydrogen 3.041 N/A GLU 182.A N GLU 182.A OE1 no hydrogen 2.919 N/A VAL 183.A N ALA 180.A O no hydrogen 3.132 N/A VAL 184.A N PRO 181.A O no hydrogen 2.958 N/A THR 185.A N PRO 181.A O no hydrogen 2.984 N/A ARG 186.A N GLU 182.A O no hydrogen 2.908 N/A TYR 189.A N ARG 170.A O no hydrogen 2.846 N/A LYS 192.A NZ VAL 254.A O no hydrogen 3.008 N/A LYS 192.A NZ ARG 257.A O no hydrogen 2.941 N/A VAL 193.A N GLY 190.A O no hydrogen 3.091 N/A ASP 194.A N PRO 191.A O no hydrogen 2.950 N/A TRP 196.A N LYS 192.A O no hydrogen 3.111 N/A SER 197.A N VAL 193.A O no hydrogen 3.156 N/A SER 197.A OG TRP 178.A O no hydrogen 2.721 N/A SER 197.A OG VAL 193.A O no hydrogen 3.154 N/A LEU 198.A N ASP 194.A O no hydrogen 3.016 N/A GLY 199.A N ILE 195.A O no hydrogen 3.004 N/A ILE 200.A N TRP 196.A O no hydrogen 3.013 N/A MET 201.A N SER 197.A O no hydrogen 2.866 N/A ALA 202.A N LEU 198.A O no hydrogen 2.911 N/A ILE 203.A N GLY 199.A O no hydrogen 3.089 N/A GLU 204.A N ILE 200.A O no hydrogen 2.964 N/A MET 205.A N MET 201.A O no hydrogen 2.995 N/A ILE 206.A N ALA 202.A O no hydrogen 3.012 N/A GLU 207.A N ILE 203.A O no hydrogen 2.776 N/A GLY 208.A N GLU 204.A O no hydrogen 2.774 N/A GLU 215.A N TYR 212.A O no hydrogen 2.925 N/A LEU 218.A N ASN 216.A OD1 no hydrogen 3.055 N/A ARG 219.A N ASN 216.A O no hydrogen 2.863 N/A ALA 220.A N ASN 216.A O no hydrogen 2.946 N/A LEU 221.A N PRO 217.A O no hydrogen 3.072 N/A TYR 222.A N LEU 218.A O no hydrogen 3.387 N/A LEU 223.A N ARG 219.A O no hydrogen 2.870 N/A ILE 224.A N ALA 220.A O no hydrogen 2.819 N/A ALA 225.A N LEU 221.A O no hydrogen 3.034 N/A THR 226.A N TYR 222.A O no hydrogen 2.900 N/A THR 226.A OG1 TYR 222.A O no hydrogen 2.883 N/A THR 226.A OG1 LEU 223.A O no hydrogen 3.467 N/A ASN 227.A N LEU 223.A O no hydrogen 2.752 N/A ASN 227.A ND2 TYR 212.A OH no hydrogen 3.132 N/A GLY 228.A N ILE 224.A O no hydrogen 3.113 N/A THR 229.A OG1 LEU 250.A O no hydrogen 2.865 N/A GLN 233.A N GLU 207.A OE2 no hydrogen 2.802 N/A ASN 234.A ND2 GLU 236.A OE1 no hydrogen 3.378 N/A LYS 237.A N ASN 234.A O no hydrogen 3.097 N/A LEU 238.A N PRO 235.A O no hydrogen 2.939 N/A SER 239.A N GLU 112.A OE2 no hydrogen 2.843 N/A SER 239.A OG GLU 112.A OE1 no hydrogen 2.568 N/A SER 239.A OG GLU 112.A OE2 no hydrogen 3.519 N/A PHE 242.A N SER 239.A OG no hydrogen 3.135 N/A ARG 243.A N SER 239.A O no hydrogen 3.003 N/A ARG 243.A NH1 PRO 235.A O no hydrogen 3.101 N/A ASP 244.A N ALA 240.A O no hydrogen 2.982 N/A PHE 245.A N ILE 241.A O no hydrogen 2.983 N/A LEU 246.A N PHE 242.A O no hydrogen 2.945 N/A ASN 247.A N ARG 243.A O no hydrogen 3.018 N/A ARG 248.A N ASP 244.A O no hydrogen 3.062 N/A CYS 249.A N PHE 245.A O no hydrogen 3.058 N/A CYS 249.A SG PHE 245.A O no hydrogen 3.558 N/A LEU 250.A N LEU 246.A O no hydrogen 2.868 N/A ASP 253.A N ASP 251.A OD1 no hydrogen 2.884 N/A LYS 256.A N ASP 253.A O no hydrogen 3.091 N/A LYS 256.A N ASP 253.A OD1 no hydrogen 3.345 N/A ARG 257.A N ASP 253.A O no hydrogen 2.916 N/A ARG 257.A NE ASP 251.A O no hydrogen 2.846 N/A ARG 257.A NH1 GLU 182.A OE2 no hydrogen 2.667 N/A ARG 257.A NH1 LYS 192.A O no hydrogen 2.993 N/A ARG 257.A NH2 GLU 182.A OE1 no hydrogen 2.840 N/A ARG 257.A NH2 GLU 182.A OE2 no hydrogen 3.426 N/A ARG 257.A NH2 ASP 251.A O no hydrogen 2.998 N/A GLY 258.A N ARG 248.A O no hydrogen 2.915 N/A SER 259.A N GLU 262.A OE1 no hydrogen 3.023 N/A LYS 261.A NZ GLU 127.A OE2 no hydrogen 2.566 N/A GLU 262.A N SER 259.A OG no hydrogen 3.055 N/A LEU 263.A N SER 259.A O no hydrogen 2.936 N/A LEU 264.A N ALA 260.A O no hydrogen 2.983 N/A GLN 265.A N GLU 262.A O no hydrogen 3.078 N/A HIS 266.A N LEU 263.A O no hydrogen 2.983 N/A HIS 266.A NE2 ASP 244.A OD2 no hydrogen 2.824 N/A PHE 268.A N HIS 266.A ND1 no hydrogen 2.974 N/A LEU 269.A N HIS 266.A O no hydrogen 3.138 N/A LYS 270.A N GLN 267.A O no hydrogen 2.985 N/A ILE 271.A N PHE 268.A O no hydrogen 3.231 N/A ALA 272.A N LEU 269.A O no hydrogen 3.061 N/A LYS 273.A N GLY 113.A O no hydrogen 2.974 N/A LYS 273.A NZ ASP 111.A OD2 no hydrogen 2.656 N/A SER 277.A N PRO 274.A O no hydrogen 2.940 N/A SER 277.A OG PRO 274.A O no hydrogen 2.837 N/A LEU 278.A N LEU 275.A O no hydrogen 2.954 N/A THR 279.A N SER 276.A O no hydrogen 3.115 N/A THR 279.A OG1 MET 148.A O no hydrogen 2.864 N/A THR 279.A OG1 SER 276.A O no hydrogen 3.316 N/A ILE 282.A N LEU 278.A O no hydrogen 2.990 N/A ALA 283.A N THR 279.A O no hydrogen 2.836 N/A ALA 284.A N PRO 280.A O no hydrogen 2.861 N/A ALA 285.A N LEU 281.A O no hydrogen 2.798 N/A LYS 286.A N ILE 282.A O no hydrogen 2.972 N/A LYS 286.A NZ ALA 97.A O no hydrogen 3.042 N/A GLU 287.A N ALA 283.A O no hydrogen 3.052 N/A ALA 288.A N ALA 284.A O no hydrogen 3.073 N/A THR 289.A N LYS 286.A O no hydrogen 3.273 N/A THR 289.A OG1 ALA 285.A O no hydrogen 2.750 N/A THR 289.A OG1 LYS 286.A O no hydrogen 3.379 N/A LYS 290.A NZ GLU 287.A O no hydrogen 3.359 N/A LYS 290.A NZ GLU 287.A OE2 no hydrogen 3.093 N/A