1AJAA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
Knots found
sequence length
449
structure length
435
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Non specific mono-esterase
molecule keywords ALKALINE PHOSPHATASE
total genus 158
structure length 435
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajaA00
4UOOA 3B5QA 1EW8A 2XR9A 2W5SA 5AJ9A 1EW2A 4KAYA 4ZG9A 4UPLA 4FDJA 4UPHA 3T00A 1SHNA 1HJKA 2W5QA 4KM4A 3TWZA 3WBHA 1Y6VA 3BDFA 5DLWA 5L0KA 3UN5A 1ANJA 5L0EA 4CYSA 2W5XA 4GTXA 3E2DA 1EQJA 3SZZA 4UORA 5IJQA 4MHXA 5LRNA 4FDIA 1EI6A 5GRRA 3NKQA 1K7HA 4GTZA 3KD8A 4UOPA 1EJJA 3M8YA 5EGHA 1KH4A 1URBA 1HDHA 3IGYB 1KH5A 4LRCA 4LREA 3IDDA 3T02A 3LXQA 2IUCA 3NKOA 3WAVA 3NVLA 2GSOA 2W8SA 3BDGB 4LRAA 1E2SP 4GTYA 1AJBA 2X98A 4LR8A 1O98A 4GTWA 3MK1A 3CMRA 1ED8A 4LR7A 5INHA 1AUKA 1E33P 4UPKA 5LIAA 2IFYA 3NKMA 2G9YA 4B56A 3DPCA 4LRDA 2GSUA 5LQQA 1KH7A 1URAA 1ELZA 3M8ZA 4YR1A 1HQAA 4N7TA 1ELXA 5L0BA 2W5TA 1E3CP 3NKPA 4ZGAA 1N2LA 4LRBA 1O99A 3DYCA 4LQYA 2W5WA 3WAXA 2RH6A 3UN3A 3MK0A 4CXUA 3WAYA 2XRGA 4NWXA 3M8WA 1ALHA 3A52A 4KAVA 4TN0A 5C66A 4LRFA 4ZG6A 3UN2A 2GSNA 4CYRA 2W8DA 2GLQA 1P49A 1KH9A 5DLVA 5LRMA 3OT9A 1ALJA 1AJCA 4KJDA 4LR2A 2VQRA 4LR9A 5DLTA 1ALIA 1N2KA 1ELYA 5TJ3A 3WAWA 1AJDA 4NWJA 2ZKTA 3T01A 4UPIA 1KHJA 3UNYA 3M7VA 1ZEFA 2W5VA 1ZEBA 3BDGA 2D1GA 5EGEA 1KHKA 2IUCB 5KXAA 1AJAA 4CXKA 3BDHA 1FSUA 4QAXA 3UO0A 3TX0A 1EW9A 2ANHA 1E1ZP 3NKNA 3Q3QA 3ED4A 4CXSA 3NKRA 4ZG7A 5HRTA 1ANIA 5GOVA 1ALKA 3MK2A 4MY4A 1B8JA 1SHQA 1ED9A 4KJGA 3IGZB 5K4PA 1KHNA 1Y7AA 5IJSA 4MIVA 2W5RA 3TG0A 1KHLA 2GA3A 2QZUA 3SZYA 1ZEDA
chains in the Genus database with same CATH superfamily
4UOOA 3B5QA 1EW8A 2XR9A 2W5SA 5AJ9A 1EW2A 4KAYA 4ZG9A 4UPLA 4FDJA 4UPHA 3T00A 1SHNA 1HJKA 2W5QA 4KM4A 3TWZA 3WBHA 1Y6VA 3BDFA 5DLWA 5L0KA 3UN5A 1ANJA 5L0EA 4CYSA 2W5XA 4GTXA 3E2DA 1EQJA 3SZZA 4UORA 5IJQA 4MHXA 5LRNA 4FDIA 1EI6A 5GRRA 3NKQA 1K7HA 4GTZA 3KD8A 4UOPA 1EJJA 3M8YA 5EGHA 1KH4A 1URBA 1HDHA 3IGYB 1KH5A 4LRCA 4LREA 3IDDA 3T02A 3LXQA 2IUCA 3NKOA 3WAVA 3NVLA 2GSOA 2W8SA 3BDGB 4LRAA 1E2SP 4GTYA 1AJBA 2X98A 4LR8A 1O98A 4GTWA 3MK1A 3CMRA 1ED8A 4LR7A 5INHA 1AUKA 1E33P 4UPKA 5LIAA 2IFYA 3NKMA 2G9YA 4B56A 3DPCA 4LRDA 2GSUA 5LQQA 1KH7A 1URAA 1ELZA 3M8ZA 4YR1A 1HQAA 4N7TA 1ELXA 5L0BA 2W5TA 1E3CP 3NKPA 4ZGAA 1N2LA 4LRBA 1O99A 3DYCA 4LQYA 2W5WA 3WAXA 2RH6A 3UN3A 3MK0A 4CXUA 3WAYA 2XRGA 4NWXA 3M8WA 1ALHA 3A52A 4KAVA 4TN0A 5C66A 4LRFA 4ZG6A 3UN2A 2GSNA 4CYRA 2W8DA 2GLQA 1P49A 1KH9A 5DLVA 5LRMA 3OT9A 1ALJA 1AJCA 4KJDA 4LR2A 2VQRA 4LR9A 5DLTA 1ALIA 1N2KA 1ELYA 5TJ3A 3WAWA 1AJDA 4NWJA 2ZKTA 3T01A 4UPIA 1KHJA 3UNYA 3M7VA 1ZEFA 2W5VA 1ZEBA 3BDGA 2D1GA 5EGEA 1KHKA 2IUCB 5KXAA 1AJAA 4CXKA 3BDHA 1FSUA 4QAXA 3UO0A 3TX0A 1EW9A 2ANHA 1E1ZP 3NKNA 3Q3QA 3ED4A 4CXSA 3NKRA 4ZG7A 5HRTA 1ANIA 5GOVA 1ALKA 3MK2A 4MY4A 1B8JA 1SHQA 1ED9A 4KJGA 3IGZB 5K4PA 1KHNA 1Y7AA 5IJSA 4MIVA 2W5RA 3TG0A 1KHLA 2GA3A 2QZUA 3SZYA 1ZEDA
chains in the Genus database with same CATH topology
4UOOA 3B5QA 1EW8A 2XR9A 2W5SA 5AJ9A 1EW2A 4KAYA 4ZG9A 4UPLA 4FDJA 4UPHA 3T00A 1SHNA 1HJKA 2W5QA 4KM4A 3TWZA 3WBHA 1Y6VA 3BDFA 5DLWA 5L0KA 3UN5A 1ANJA 5L0EA 4CYSA 2W5XA 4GTXA 3E2DA 1EQJA 3SZZA 4UORA 5IJQA 4MHXA 5LRNA 4FDIA 1EI6A 5GRRA 3NKQA 1K7HA 4GTZA 3KD8A 4UOPA 1EJJA 3M8YA 5EGHA 1KH4A 1URBA 1HDHA 3IGYB 1KH5A 4LRCA 4LREA 3IDDA 3T02A 3LXQA 2IUCA 3NKOA 3WAVA 3NVLA 2GSOA 2W8SA 3BDGB 4LRAA 1E2SP 4GTYA 1AJBA 2X98A 4LR8A 1O98A 4GTWA 3MK1A 3CMRA 1ED8A 4LR7A 5INHA 1AUKA 1E33P 4UPKA 5LIAA 2IFYA 3NKMA 2G9YA 4B56A 3DPCA 4LRDA 2GSUA 5LQQA 1KH7A 1URAA 1ELZA 3M8ZA 4YR1A 1HQAA 4N7TA 1ELXA 5L0BA 2W5TA 1E3CP 3NKPA 4ZGAA 1N2LA 4LRBA 1O99A 3DYCA 4LQYA 2W5WA 3WAXA 2RH6A 3UN3A 3MK0A 4CXUA 3WAYA 2XRGA 4NWXA 3M8WA 1ALHA 3A52A 4KAVA 4TN0A 5C66A 4LRFA 4ZG6A 3UN2A 2GSNA 4CYRA 2W8DA 2GLQA 1P49A 1KH9A 5DLVA 5LRMA 3OT9A 1ALJA 1AJCA 4KJDA 4LR2A 2VQRA 4LR9A 5DLTA 1ALIA 1N2KA 1ELYA 5TJ3A 3WAWA 1AJDA 4NWJA 2ZKTA 3T01A 4UPIA 1KHJA 3UNYA 3M7VA 1ZEFA 2W5VA 1ZEBA 3BDGA 2D1GA 5EGEA 1KHKA 2IUCB 5KXAA 1AJAA 4CXKA 3BDHA 1FSUA 4QAXA 3UO0A 3TX0A 1EW9A 2ANHA 1E1ZP 3NKNA 3Q3QA 3ED4A 4CXSA 3NKRA 4ZG7A 5HRTA 1ANIA 5GOVA 1ALKA 3MK2A 4MY4A 1B8JA 1SHQA 1ED9A 4KJGA 3IGZB 5K4PA 1KHNA 1Y7AA 5IJSA 4MIVA 2W5RA 3TG0A 1KHLA 2GA3A 2QZUA 3SZYA 1ZEDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UOO A;  3B5Q A;  1EW8 A;  2XR9 A;  2W5S A;  5AJ9 A;  1EW2 A;  4KAY A;  4ZG9 A;  4UPL A;  4FDJ A;  4UPH A;  3T00 A;  1SHN A;  1HJK A;  2W5Q A;  4KM4 A;  3TWZ A;  3WBH A;  1Y6V A;  3BDF A;  5DLW A;  5L0K A;  3UN5 A;  1ANJ A;  5L0E A;  4CYS A;  2W5X A;  4GTX A;  3E2D A;  1EQJ A;  3SZZ A;  4UOR A;  5IJQ A;  4MHX A;  5LRN A;  4FDI A;  1EI6 A;  5GRR A;  3NKQ A;  1K7H A;  4GTZ A;  3KD8 A;  4UOP A;  1EJJ A;  3M8Y A;  5EGH A;  1KH4 A;  1URB A;  1HDH A;  3IGY B;  1KH5 A;  4LRC A;  4LRE A;  3IDD A;  3T02 A;  3LXQ A;  2IUC A;  3NKO A;  3WAV A;  3NVL A;  2GSO A;  2W8S A;  3BDG B;  4LRA A;  1E2S P;  4GTY A;  1AJB A;  2X98 A;  4LR8 A;  1O98 A;  4GTW A;  3MK1 A;  3CMR A;  1ED8 A;  4LR7 A;  5INH A;  1AUK A;  1E33 P;  4UPK A;  5LIA A;  2IFY A;  3NKM A;  2G9Y A;  4B56 A;  3DPC A;  4LRD A;  2GSU A;  5LQQ A;  1KH7 A;  1URA A;  1ELZ A;  3M8Z A;  4YR1 A;  1HQA A;  4N7T A;  1ELX A;  5L0B A;  2W5T A;  1E3C P;  3NKP A;  4ZGA A;  1N2L A;  4LRB A;  1O99 A;  3DYC A;  4LQY A;  2W5W A;  3WAX A;  2RH6 A;  3UN3 A;  3MK0 A;  4CXU A;  3WAY A;  2XRG A;  4NWX A;  3M8W A;  1ALH A;  3A52 A;  4KAV A;  4TN0 A;  5C66 A;  4LRF A;  4ZG6 A;  3UN2 A;  2GSN A;  4CYR A;  2W8D A;  2GLQ A;  1P49 A;  1KH9 A;  5DLV A;  5LRM A;  3OT9 A;  1ALJ A;  1AJC A;  4KJD A;  4LR2 A;  2VQR A;  4LR9 A;  5DLT A;  1ALI A;  1N2K A;  1ELY A;  5TJ3 A;  3WAW A;  1AJD A;  4NWJ A;  2ZKT A;  3T01 A;  4UPI A;  1KHJ A;  3UNY A;  3M7V A;  1ZEF A;  2W5V A;  1ZEB A;  3BDG A;  2D1G A;  5EGE A;  1KHK A;  2IUC B;  5KXA A;  1AJA A;  4CXK A;  3BDH A;  1FSU A;  4QAX A;  3UO0 A;  3TX0 A;  1EW9 A;  2ANH A;  1E1Z P;  3NKN A;  3Q3Q A;  3ED4 A;  4CXS A;  3NKR A;  4ZG7 A;  5HRT A;  1ANI A;  5GOV A;  1ALK A;  3MK2 A;  4MY4 A;  1B8J A;  1SHQ A;  1ED9 A;  4KJG A;  3IGZ B;  5K4P A;  1KHN A;  1Y7A A;  5IJS A;  4MIV A;  2W5R A;  3TG0 A;  1KHL A;  2GA3 A;  2QZU A;  3SZY A;  1ZED A; 
#chains in the Genus database with same CATH topology
 4UOO A;  3B5Q A;  1EW8 A;  2XR9 A;  2W5S A;  5AJ9 A;  1EW2 A;  4KAY A;  4ZG9 A;  4UPL A;  4FDJ A;  4UPH A;  3T00 A;  1SHN A;  1HJK A;  2W5Q A;  4KM4 A;  3TWZ A;  3WBH A;  1Y6V A;  3BDF A;  5DLW A;  5L0K A;  3UN5 A;  1ANJ A;  5L0E A;  4CYS A;  2W5X A;  4GTX A;  3E2D A;  1EQJ A;  3SZZ A;  4UOR A;  5IJQ A;  4MHX A;  5LRN A;  4FDI A;  1EI6 A;  5GRR A;  3NKQ A;  1K7H A;  4GTZ A;  3KD8 A;  4UOP A;  1EJJ A;  3M8Y A;  5EGH A;  1KH4 A;  1URB A;  1HDH A;  3IGY B;  1KH5 A;  4LRC A;  4LRE A;  3IDD A;  3T02 A;  3LXQ A;  2IUC A;  3NKO A;  3WAV A;  3NVL A;  2GSO A;  2W8S A;  3BDG B;  4LRA A;  1E2S P;  4GTY A;  1AJB A;  2X98 A;  4LR8 A;  1O98 A;  4GTW A;  3MK1 A;  3CMR A;  1ED8 A;  4LR7 A;  5INH A;  1AUK A;  1E33 P;  4UPK A;  5LIA A;  2IFY A;  3NKM A;  2G9Y A;  4B56 A;  3DPC A;  4LRD A;  2GSU A;  5LQQ A;  1KH7 A;  1URA A;  1ELZ A;  3M8Z A;  4YR1 A;  1HQA A;  4N7T A;  1ELX A;  5L0B A;  2W5T A;  1E3C P;  3NKP A;  4ZGA A;  1N2L A;  4LRB A;  1O99 A;  3DYC A;  4LQY A;  2W5W A;  3WAX A;  2RH6 A;  3UN3 A;  3MK0 A;  4CXU A;  3WAY A;  2XRG A;  4NWX A;  3M8W A;  1ALH A;  3A52 A;  4KAV A;  4TN0 A;  5C66 A;  4LRF A;  4ZG6 A;  3UN2 A;  2GSN A;  4CYR A;  2W8D A;  2GLQ A;  1P49 A;  1KH9 A;  5DLV A;  5LRM A;  3OT9 A;  1ALJ A;  1AJC A;  4KJD A;  4LR2 A;  2VQR A;  4LR9 A;  5DLT A;  1ALI A;  1N2K A;  1ELY A;  5TJ3 A;  3WAW A;  1AJD A;  4NWJ A;  2ZKT A;  3T01 A;  4UPI A;  1KHJ A;  3UNY A;  3M7V A;  1ZEF A;  2W5V A;  1ZEB A;  3BDG A;  2D1G A;  5EGE A;  1KHK A;  2IUC B;  5KXA A;  1AJA A;  4CXK A;  3BDH A;  1FSU A;  4QAX A;  3UO0 A;  3TX0 A;  1EW9 A;  2ANH A;  1E1Z P;  3NKN A;  3Q3Q A;  3ED4 A;  4CXS A;  3NKR A;  4ZG7 A;  5HRT A;  1ANI A;  5GOV A;  1ALK A;  3MK2 A;  4MY4 A;  1B8J A;  1SHQ A;  1ED9 A;  4KJG A;  3IGZ B;  5K4P A;  1KHN A;  1Y7A A;  5IJS A;  4MIV A;  2W5R A;  3TG0 A;  1KHL A;  2GA3 A;  2QZU A;  3SZY A;  1ZED A; 
#chains in the Genus database with same CATH homology
 4UOO A;  3B5Q A;  1EW8 A;  2XR9 A;  2W5S A;  5AJ9 A;  1EW2 A;  4KAY A;  4ZG9 A;  4UPL A;  4FDJ A;  4UPH A;  3T00 A;  1SHN A;  1HJK A;  2W5Q A;  4KM4 A;  3TWZ A;  3WBH A;  1Y6V A;  3BDF A;  5DLW A;  5L0K A;  3UN5 A;  1ANJ A;  5L0E A;  4CYS A;  2W5X A;  4GTX A;  3E2D A;  1EQJ A;  3SZZ A;  4UOR A;  5IJQ A;  4MHX A;  5LRN A;  4FDI A;  1EI6 A;  5GRR A;  3NKQ A;  1K7H A;  4GTZ A;  3KD8 A;  4UOP A;  1EJJ A;  3M8Y A;  5EGH A;  1KH4 A;  1URB A;  1HDH A;  3IGY B;  1KH5 A;  4LRC A;  4LRE A;  3IDD A;  3T02 A;  3LXQ A;  2IUC A;  3NKO A;  3WAV A;  3NVL A;  2GSO A;  2W8S A;  3BDG B;  4LRA A;  1E2S P;  4GTY A;  1AJB A;  2X98 A;  4LR8 A;  1O98 A;  4GTW A;  3MK1 A;  3CMR A;  1ED8 A;  4LR7 A;  5INH A;  1AUK A;  1E33 P;  4UPK A;  5LIA A;  2IFY A;  3NKM A;  2G9Y A;  4B56 A;  3DPC A;  4LRD A;  2GSU A;  5LQQ A;  1KH7 A;  1URA A;  1ELZ A;  3M8Z A;  4YR1 A;  1HQA A;  4N7T A;  1ELX A;  5L0B A;  2W5T A;  1E3C P;  3NKP A;  4ZGA A;  1N2L A;  4LRB A;  1O99 A;  3DYC A;  4LQY A;  2W5W A;  3WAX A;  2RH6 A;  3UN3 A;  3MK0 A;  4CXU A;  3WAY A;  2XRG A;  4NWX A;  3M8W A;  1ALH A;  3A52 A;  4KAV A;  4TN0 A;  5C66 A;  4LRF A;  4ZG6 A;  3UN2 A;  2GSN A;  4CYR A;  2W8D A;  2GLQ A;  1P49 A;  1KH9 A;  5DLV A;  5LRM A;  3OT9 A;  1ALJ A;  1AJC A;  4KJD A;  4LR2 A;  2VQR A;  4LR9 A;  5DLT A;  1ALI A;  1N2K A;  1ELY A;  5TJ3 A;  3WAW A;  1AJD A;  4NWJ A;  2ZKT A;  3T01 A;  4UPI A;  1KHJ A;  3UNY A;  3M7V A;  1ZEF A;  2W5V A;  1ZEB A;  3BDG A;  2D1G A;  5EGE A;  1KHK A;  2IUC B;  5KXA A;  1AJA A;  4CXK A;  3BDH A;  1FSU A;  4QAX A;  3UO0 A;  3TX0 A;  1EW9 A;  2ANH A;  1E1Z P;  3NKN A;  3Q3Q A;  3ED4 A;  4CXS A;  3NKR A;  4ZG7 A;  5HRT A;  1ANI A;  5GOV A;  1ALK A;  3MK2 A;  4MY4 A;  1B8J A;  1SHQ A;  1ED9 A;  4KJG A;  3IGZ B;  5K4P A;  1KHN A;  1Y7A A;  5IJS A;  4MIV A;  2W5R A;  3TG0 A;  1KHL A;  2GA3 A;  2QZU A;  3SZY A;  1ZED A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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