1AJAA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
Knots found
sequence length
449
structure length
435
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule keywords ALKALINE PHOSPHATASE
molecule tags Non specific mono-esterase
source organism Escherichia coli
total genus 158
structure length 435
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajaA00
2D1GA 3SZYA 4UOPA 3BDFA 3ED4A 5AJ9A 1EW9A 2W5TA 1EI6A 1HQAA 4CYSA 4LQYA 3UNYA 4CXKA 5TJ3A 2IUCA 1N2KA 1SHNA 4KJDA 5INHA 4GTYA 3IGZB 2XR9A 4CXSA 3NKMA 1Y6VA 3NKRA 1SHQA 2W5RA 3OT9A 4UORA 3TG0A 1ELZA 4N7TA 5LRNA 1E33P 1ELXA 4CXUA 4LR8A 1AJAA 3UO0A 3NKQA 1HJKA 4FDJA 4GTWA 3IGYB 3NKPA 1ELYA 2W5VA 3UN2A 4MHXA 2XRGA 4NWJA 4LRAA 3IDDA 3LXQA 1AJDA 3WAXA 3UN3A 1AJBA 2W5QA 5L0EA 4ZGAA 1EJJA 5C66A 5LIAA 4KJGA 3Q3QA 4FDIA 5GOVA 4B56A 1K7HA 1AJCA 4LREA 2GSUA 4KAYA 4ZG7A 2IFYA 3MK1A 3MK2A 3BDHA 2GSNA 5DLTA 3WAVA 5LQQA 2W5SA 3DYCA 2G9YA 1ALKA 1ZEBA 1EW2A 1KH4A 3MK0A 5LRMA 2W5XA 5IJSA 1URAA 4UPKA 2GLQA 2W5WA 1ALJA 3A52A 4NWXA 4GTZA 1HDHA 4LR7A 4UPIA 5EGHA 2GA3A 2ANHA 4CYRA 3WBHA 5GRRA 1E1ZP 1KHLA 1FSUA 3CMRA 4GTXA 3KD8A 3T00A 3DPCA 3BDGB 3M8WA 1ANJA 3E2DA 1KHJA 4ZG6A 1E2SP 2QZUA 1ALIA 3NKNA 4LR9A 3TWZA 5DLWA 4MY4A 1B8JA 5L0KA 1AUKA 5IJQA 1ZEDA 3NVLA 4KAVA 1ALHA 2VQRA 4LRDA 4TN0A 5KXAA 5DLVA 1O99A 3TX0A 3WAWA 3BDGA 1ED9A 1KH5A 4ZG9A 1KH7A 4LR2A 4LRCA 4QAXA 3WAYA 1E3CP 1P49A 2W8SA 2X98A 1ANIA 1URBA 3T02A 4KM4A 4UOOA 1EQJA 1Y7AA 1N2LA 3B5QA 1EW8A 3UN5A 3NKOA 4LRBA 5K4PA 3M7VA 5L0BA 1KHKA 1ED8A 2ZKTA 3M8YA 2RH6A 4UPHA 1KH9A 1O98A 2W8DA 2IUCB 4LRFA 1ZEFA 2GSOA 5EGEA 3T01A 3SZZA 4UPLA 3M8ZA 4YR1A 4MIVA 5HRTA 1KHNA
chains in the Genus database with same CATH superfamily
2D1GA 3SZYA 4UOPA 3BDFA 3ED4A 5AJ9A 1EW9A 2W5TA 1EI6A 1HQAA 4CYSA 4LQYA 3UNYA 4CXKA 5TJ3A 2IUCA 1N2KA 1SHNA 4KJDA 5INHA 4GTYA 3IGZB 2XR9A 4CXSA 3NKMA 1Y6VA 3NKRA 1SHQA 2W5RA 3OT9A 4UORA 3TG0A 1ELZA 4N7TA 5LRNA 1E33P 1ELXA 4CXUA 4LR8A 1AJAA 3UO0A 3NKQA 1HJKA 4FDJA 4GTWA 3IGYB 3NKPA 1ELYA 2W5VA 3UN2A 4MHXA 2XRGA 4NWJA 4LRAA 3IDDA 3LXQA 1AJDA 3WAXA 3UN3A 1AJBA 2W5QA 5L0EA 4ZGAA 1EJJA 5C66A 5LIAA 4KJGA 3Q3QA 4FDIA 5GOVA 4B56A 1K7HA 1AJCA 4LREA 2GSUA 4KAYA 4ZG7A 2IFYA 3MK1A 3MK2A 3BDHA 2GSNA 5DLTA 3WAVA 5LQQA 2W5SA 3DYCA 2G9YA 1ALKA 1ZEBA 1EW2A 1KH4A 3MK0A 5LRMA 2W5XA 5IJSA 1URAA 4UPKA 2GLQA 2W5WA 1ALJA 3A52A 4NWXA 4GTZA 1HDHA 4LR7A 4UPIA 5EGHA 2GA3A 2ANHA 4CYRA 3WBHA 5GRRA 1E1ZP 1KHLA 1FSUA 3CMRA 4GTXA 3KD8A 3T00A 3DPCA 3BDGB 3M8WA 1ANJA 3E2DA 1KHJA 4ZG6A 1E2SP 2QZUA 1ALIA 3NKNA 4LR9A 3TWZA 5DLWA 4MY4A 1B8JA 5L0KA 1AUKA 5IJQA 1ZEDA 3NVLA 4KAVA 1ALHA 2VQRA 4LRDA 4TN0A 5KXAA 5DLVA 1O99A 3TX0A 3WAWA 3BDGA 1ED9A 1KH5A 4ZG9A 1KH7A 4LR2A 4LRCA 4QAXA 3WAYA 1E3CP 1P49A 2W8SA 2X98A 1ANIA 1URBA 3T02A 4KM4A 4UOOA 1EQJA 1Y7AA 1N2LA 3B5QA 1EW8A 3UN5A 3NKOA 4LRBA 5K4PA 3M7VA 5L0BA 1KHKA 1ED8A 2ZKTA 3M8YA 2RH6A 4UPHA 1KH9A 1O98A 2W8DA 2IUCB 4LRFA 1ZEFA 2GSOA 5EGEA 3T01A 3SZZA 4UPLA 3M8ZA 4YR1A 4MIVA 5HRTA 1KHNA
chains in the Genus database with same CATH topology
2D1GA 3SZYA 4UOPA 3BDFA 3ED4A 5AJ9A 1EW9A 2W5TA 1EI6A 1HQAA 4CYSA 4LQYA 3UNYA 4CXKA 5TJ3A 2IUCA 1N2KA 1SHNA 4KJDA 5INHA 4GTYA 3IGZB 2XR9A 4CXSA 3NKMA 1Y6VA 3NKRA 1SHQA 2W5RA 3OT9A 4UORA 3TG0A 1ELZA 4N7TA 5LRNA 1E33P 1ELXA 4CXUA 4LR8A 1AJAA 3UO0A 3NKQA 1HJKA 4FDJA 4GTWA 3IGYB 3NKPA 1ELYA 2W5VA 3UN2A 4MHXA 2XRGA 4NWJA 4LRAA 3IDDA 3LXQA 1AJDA 3WAXA 3UN3A 1AJBA 2W5QA 5L0EA 4ZGAA 1EJJA 5C66A 5LIAA 4KJGA 3Q3QA 4FDIA 5GOVA 4B56A 1K7HA 1AJCA 4LREA 2GSUA 4KAYA 4ZG7A 2IFYA 3MK1A 3MK2A 3BDHA 2GSNA 5DLTA 3WAVA 5LQQA 2W5SA 3DYCA 2G9YA 1ALKA 1ZEBA 1EW2A 1KH4A 3MK0A 5LRMA 2W5XA 5IJSA 1URAA 4UPKA 2GLQA 2W5WA 1ALJA 3A52A 4NWXA 4GTZA 1HDHA 4LR7A 4UPIA 5EGHA 2GA3A 2ANHA 4CYRA 3WBHA 5GRRA 1E1ZP 1KHLA 1FSUA 3CMRA 4GTXA 3KD8A 3T00A 3DPCA 3BDGB 3M8WA 1ANJA 3E2DA 1KHJA 4ZG6A 1E2SP 2QZUA 1ALIA 3NKNA 4LR9A 3TWZA 5DLWA 4MY4A 1B8JA 5L0KA 1AUKA 5IJQA 1ZEDA 3NVLA 4KAVA 1ALHA 2VQRA 4LRDA 4TN0A 5KXAA 5DLVA 1O99A 3TX0A 3WAWA 3BDGA 1ED9A 1KH5A 4ZG9A 1KH7A 4LR2A 4LRCA 4QAXA 3WAYA 1E3CP 1P49A 2W8SA 2X98A 1ANIA 1URBA 3T02A 4KM4A 4UOOA 1EQJA 1Y7AA 1N2LA 3B5QA 1EW8A 3UN5A 3NKOA 4LRBA 5K4PA 3M7VA 5L0BA 1KHKA 1ED8A 2ZKTA 3M8YA 2RH6A 4UPHA 1KH9A 1O98A 2W8DA 2IUCB 4LRFA 1ZEFA 2GSOA 5EGEA 3T01A 3SZZA 4UPLA 3M8ZA 4YR1A 4MIVA 5HRTA 1KHNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2D1G A;  3SZY A;  4UOP A;  3BDF A;  3ED4 A;  5AJ9 A;  1EW9 A;  2W5T A;  1EI6 A;  1HQA A;  4CYS A;  4LQY A;  3UNY A;  4CXK A;  5TJ3 A;  2IUC A;  1N2K A;  1SHN A;  4KJD A;  5INH A;  4GTY A;  3IGZ B;  2XR9 A;  4CXS A;  3NKM A;  1Y6V A;  3NKR A;  1SHQ A;  2W5R A;  3OT9 A;  4UOR A;  3TG0 A;  1ELZ A;  4N7T A;  5LRN A;  1E33 P;  1ELX A;  4CXU A;  4LR8 A;  1AJA A;  3UO0 A;  3NKQ A;  1HJK A;  4FDJ A;  4GTW A;  3IGY B;  3NKP A;  1ELY A;  2W5V A;  3UN2 A;  4MHX A;  2XRG A;  4NWJ A;  4LRA A;  3IDD A;  3LXQ A;  1AJD A;  3WAX A;  3UN3 A;  1AJB A;  2W5Q A;  5L0E A;  4ZGA A;  1EJJ A;  5C66 A;  5LIA A;  4KJG A;  3Q3Q A;  4FDI A;  5GOV A;  4B56 A;  1K7H A;  1AJC A;  4LRE A;  2GSU A;  4KAY A;  4ZG7 A;  2IFY A;  3MK1 A;  3MK2 A;  3BDH A;  2GSN A;  5DLT A;  3WAV A;  5LQQ A;  2W5S A;  3DYC A;  2G9Y A;  1ALK A;  1ZEB A;  1EW2 A;  1KH4 A;  3MK0 A;  5LRM A;  2W5X A;  5IJS A;  1URA A;  4UPK A;  2GLQ A;  2W5W A;  1ALJ A;  3A52 A;  4NWX A;  4GTZ A;  1HDH A;  4LR7 A;  4UPI A;  5EGH A;  2GA3 A;  2ANH A;  4CYR A;  3WBH A;  5GRR A;  1E1Z P;  1KHL A;  1FSU A;  3CMR A;  4GTX A;  3KD8 A;  3T00 A;  3DPC A;  3BDG B;  3M8W A;  1ANJ A;  3E2D A;  1KHJ A;  4ZG6 A;  1E2S P;  2QZU A;  1ALI A;  3NKN A;  4LR9 A;  3TWZ A;  5DLW A;  4MY4 A;  1B8J A;  5L0K A;  1AUK A;  5IJQ A;  1ZED A;  3NVL A;  4KAV A;  1ALH A;  2VQR A;  4LRD A;  4TN0 A;  5KXA A;  5DLV A;  1O99 A;  3TX0 A;  3WAW A;  3BDG A;  1ED9 A;  1KH5 A;  4ZG9 A;  1KH7 A;  4LR2 A;  4LRC A;  4QAX A;  3WAY A;  1E3C P;  1P49 A;  2W8S A;  2X98 A;  1ANI A;  1URB A;  3T02 A;  4KM4 A;  4UOO A;  1EQJ A;  1Y7A A;  1N2L A;  3B5Q A;  1EW8 A;  3UN5 A;  3NKO A;  4LRB A;  5K4P A;  3M7V A;  5L0B A;  1KHK A;  1ED8 A;  2ZKT A;  3M8Y A;  2RH6 A;  4UPH A;  1KH9 A;  1O98 A;  2W8D A;  2IUC B;  4LRF A;  1ZEF A;  2GSO A;  5EGE A;  3T01 A;  3SZZ A;  4UPL A;  3M8Z A;  4YR1 A;  4MIV A;  5HRT A;  1KHN A; 
#chains in the Genus database with same CATH topology
 2D1G A;  3SZY A;  4UOP A;  3BDF A;  3ED4 A;  5AJ9 A;  1EW9 A;  2W5T A;  1EI6 A;  1HQA A;  4CYS A;  4LQY A;  3UNY A;  4CXK A;  5TJ3 A;  2IUC A;  1N2K A;  1SHN A;  4KJD A;  5INH A;  4GTY A;  3IGZ B;  2XR9 A;  4CXS A;  3NKM A;  1Y6V A;  3NKR A;  1SHQ A;  2W5R A;  3OT9 A;  4UOR A;  3TG0 A;  1ELZ A;  4N7T A;  5LRN A;  1E33 P;  1ELX A;  4CXU A;  4LR8 A;  1AJA A;  3UO0 A;  3NKQ A;  1HJK A;  4FDJ A;  4GTW A;  3IGY B;  3NKP A;  1ELY A;  2W5V A;  3UN2 A;  4MHX A;  2XRG A;  4NWJ A;  4LRA A;  3IDD A;  3LXQ A;  1AJD A;  3WAX A;  3UN3 A;  1AJB A;  2W5Q A;  5L0E A;  4ZGA A;  1EJJ A;  5C66 A;  5LIA A;  4KJG A;  3Q3Q A;  4FDI A;  5GOV A;  4B56 A;  1K7H A;  1AJC A;  4LRE A;  2GSU A;  4KAY A;  4ZG7 A;  2IFY A;  3MK1 A;  3MK2 A;  3BDH A;  2GSN A;  5DLT A;  3WAV A;  5LQQ A;  2W5S A;  3DYC A;  2G9Y A;  1ALK A;  1ZEB A;  1EW2 A;  1KH4 A;  3MK0 A;  5LRM A;  2W5X A;  5IJS A;  1URA A;  4UPK A;  2GLQ A;  2W5W A;  1ALJ A;  3A52 A;  4NWX A;  4GTZ A;  1HDH A;  4LR7 A;  4UPI A;  5EGH A;  2GA3 A;  2ANH A;  4CYR A;  3WBH A;  5GRR A;  1E1Z P;  1KHL A;  1FSU A;  3CMR A;  4GTX A;  3KD8 A;  3T00 A;  3DPC A;  3BDG B;  3M8W A;  1ANJ A;  3E2D A;  1KHJ A;  4ZG6 A;  1E2S P;  2QZU A;  1ALI A;  3NKN A;  4LR9 A;  3TWZ A;  5DLW A;  4MY4 A;  1B8J A;  5L0K A;  1AUK A;  5IJQ A;  1ZED A;  3NVL A;  4KAV A;  1ALH A;  2VQR A;  4LRD A;  4TN0 A;  5KXA A;  5DLV A;  1O99 A;  3TX0 A;  3WAW A;  3BDG A;  1ED9 A;  1KH5 A;  4ZG9 A;  1KH7 A;  4LR2 A;  4LRC A;  4QAX A;  3WAY A;  1E3C P;  1P49 A;  2W8S A;  2X98 A;  1ANI A;  1URB A;  3T02 A;  4KM4 A;  4UOO A;  1EQJ A;  1Y7A A;  1N2L A;  3B5Q A;  1EW8 A;  3UN5 A;  3NKO A;  4LRB A;  5K4P A;  3M7V A;  5L0B A;  1KHK A;  1ED8 A;  2ZKT A;  3M8Y A;  2RH6 A;  4UPH A;  1KH9 A;  1O98 A;  2W8D A;  2IUC B;  4LRF A;  1ZEF A;  2GSO A;  5EGE A;  3T01 A;  3SZZ A;  4UPL A;  3M8Z A;  4YR1 A;  4MIV A;  5HRT A;  1KHN A; 
#chains in the Genus database with same CATH homology
 2D1G A;  3SZY A;  4UOP A;  3BDF A;  3ED4 A;  5AJ9 A;  1EW9 A;  2W5T A;  1EI6 A;  1HQA A;  4CYS A;  4LQY A;  3UNY A;  4CXK A;  5TJ3 A;  2IUC A;  1N2K A;  1SHN A;  4KJD A;  5INH A;  4GTY A;  3IGZ B;  2XR9 A;  4CXS A;  3NKM A;  1Y6V A;  3NKR A;  1SHQ A;  2W5R A;  3OT9 A;  4UOR A;  3TG0 A;  1ELZ A;  4N7T A;  5LRN A;  1E33 P;  1ELX A;  4CXU A;  4LR8 A;  1AJA A;  3UO0 A;  3NKQ A;  1HJK A;  4FDJ A;  4GTW A;  3IGY B;  3NKP A;  1ELY A;  2W5V A;  3UN2 A;  4MHX A;  2XRG A;  4NWJ A;  4LRA A;  3IDD A;  3LXQ A;  1AJD A;  3WAX A;  3UN3 A;  1AJB A;  2W5Q A;  5L0E A;  4ZGA A;  1EJJ A;  5C66 A;  5LIA A;  4KJG A;  3Q3Q A;  4FDI A;  5GOV A;  4B56 A;  1K7H A;  1AJC A;  4LRE A;  2GSU A;  4KAY A;  4ZG7 A;  2IFY A;  3MK1 A;  3MK2 A;  3BDH A;  2GSN A;  5DLT A;  3WAV A;  5LQQ A;  2W5S A;  3DYC A;  2G9Y A;  1ALK A;  1ZEB A;  1EW2 A;  1KH4 A;  3MK0 A;  5LRM A;  2W5X A;  5IJS A;  1URA A;  4UPK A;  2GLQ A;  2W5W A;  1ALJ A;  3A52 A;  4NWX A;  4GTZ A;  1HDH A;  4LR7 A;  4UPI A;  5EGH A;  2GA3 A;  2ANH A;  4CYR A;  3WBH A;  5GRR A;  1E1Z P;  1KHL A;  1FSU A;  3CMR A;  4GTX A;  3KD8 A;  3T00 A;  3DPC A;  3BDG B;  3M8W A;  1ANJ A;  3E2D A;  1KHJ A;  4ZG6 A;  1E2S P;  2QZU A;  1ALI A;  3NKN A;  4LR9 A;  3TWZ A;  5DLW A;  4MY4 A;  1B8J A;  5L0K A;  1AUK A;  5IJQ A;  1ZED A;  3NVL A;  4KAV A;  1ALH A;  2VQR A;  4LRD A;  4TN0 A;  5KXA A;  5DLV A;  1O99 A;  3TX0 A;  3WAW A;  3BDG A;  1ED9 A;  1KH5 A;  4ZG9 A;  1KH7 A;  4LR2 A;  4LRC A;  4QAX A;  3WAY A;  1E3C P;  1P49 A;  2W8S A;  2X98 A;  1ANI A;  1URB A;  3T02 A;  4KM4 A;  4UOO A;  1EQJ A;  1Y7A A;  1N2L A;  3B5Q A;  1EW8 A;  3UN5 A;  3NKO A;  4LRB A;  5K4P A;  3M7V A;  5L0B A;  1KHK A;  1ED8 A;  2ZKT A;  3M8Y A;  2RH6 A;  4UPH A;  1KH9 A;  1O98 A;  2W8D A;  2IUC B;  4LRF A;  1ZEF A;  2GSO A;  5EGE A;  3T01 A;  3SZZ A;  4UPL A;  3M8Z A;  4YR1 A;  4MIV A;  5HRT A;  1KHN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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