1AJDA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 153
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
153
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE INTERMEDIATE II OF HOLO ENZYME
publication title Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Non specific mono-esterase
total genus 153
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-08-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajdA00
5IJSA 1ALJA 1SHNA 1K7HA 1KH5A 1AJDA 1ZEBA 3Q3QA 1URAA 1EW8A 4LRAA 3M8WA 3SZYA 5EGEA 1EW9A 1ELYA 1ANJA 4CYRA 1ZEDA 3UN3A 1KHNA 4KAYA 1ANIA 4GTZA 1ZEFA 5DLTA 1N2LA 5IJQA 3BDHA 5TJ3A 3E2DA 4ZG7A 3DYCA 5HRTA 2RH6A 3NKQA 5GOVA 1ELXA 2ZKTA 3UN2A 1AJAA 4TN0A 1SHQA 4ZG6A 1ALKA 3NKNA 2W8SA 4NWJA 1KH4A 3IGYB 4FDIA 3KD8A 2W5SA 1O99A 2W5TA 2X98A 1URBA 1Y7AA 2D1GA 5L0KA 1E2SP 2W5RA 4GTWA 1EW2A 4MY4A 4LR9A 1AUKA 1ELZA 4N7TA 1EJJA 3LXQA 3B5QA 4QAXA 1ALHA 2GSNA 2GSUA 3SZZA 3WAYA 5LRNA 4KJGA 1P49A 4YR1A 3NKPA 4KJDA 4B56A 5GRRA 4GTYA 1E1ZP 1KHJA 4KAVA 3WAWA 2XR9A 3M7VA 1Y6VA 3A52A 5INHA 4UOOA 4UOPA 1KH7A 3M8ZA 5L0BA 5C66A 1EI6A 2ANHA 4MHXA 3UNYA 5KXAA 1ALIA 3NKMA 3IGZB 5L0EA 3IDDA 4UPIA 2W5XA 2XRGA 3TX0A 4UPLA 5DLVA 3CMRA 4GTXA 5EGHA 5LIAA 5LRMA 3BDGB 4CXKA 3NKOA 3OT9A 4LQYA 2IFYA 1FSUA 5K4PA 3UN5A 1E3CP 3WAXA 1AJCA 1N2KA 1AJBA 3M8YA 3MK2A 3DPCA 4UORA 3T01A 4ZG9A 1E33P 3MK1A 3WAVA 1ED8A 1HDHA 4FDJA 4CXSA 4CYSA 2IUCB 4LRCA 2VQRA 3WBHA 3MK0A 3TWZA 2GA3A 2QZUA 4LRDA 4KM4A 3UO0A 4LRBA 3BDGA 3ED4A 4UPHA 4LRFA 2GSOA 5DLWA 2G9YA 5LQQA 1KH9A 4MIVA 1KHKA 4LR7A 1B8JA 1HQAA 2W5WA 3NVLA 4LR8A 4CXUA 3BDFA 3NKRA 2W5VA 3TG0A 1HJKA 2IUCA 4LREA 4ZGAA 2W5QA 1O98A 1KHLA 2W8DA 3T02A 1ED9A 4NWXA 4LR2A 2GLQA 5AJ9A 1EQJA 3T00A 4UPKA
chains in the Genus database with same CATH superfamily
5IJSA 1ALJA 1SHNA 1K7HA 1KH5A 1AJDA 1ZEBA 3Q3QA 1URAA 1EW8A 4LRAA 3M8WA 3SZYA 5EGEA 1EW9A 1ELYA 1ANJA 4CYRA 1ZEDA 3UN3A 1KHNA 4KAYA 1ANIA 4GTZA 1ZEFA 5DLTA 1N2LA 5IJQA 3BDHA 5TJ3A 3E2DA 4ZG7A 3DYCA 5HRTA 2RH6A 3NKQA 5GOVA 1ELXA 2ZKTA 3UN2A 1AJAA 4TN0A 1SHQA 4ZG6A 1ALKA 3NKNA 2W8SA 4NWJA 1KH4A 3IGYB 4FDIA 3KD8A 2W5SA 1O99A 2W5TA 2X98A 1URBA 1Y7AA 2D1GA 5L0KA 1E2SP 2W5RA 4GTWA 1EW2A 4MY4A 4LR9A 1AUKA 1ELZA 4N7TA 1EJJA 3LXQA 3B5QA 4QAXA 1ALHA 2GSNA 2GSUA 3SZZA 3WAYA 5LRNA 4KJGA 1P49A 4YR1A 3NKPA 4KJDA 4B56A 5GRRA 4GTYA 1E1ZP 1KHJA 4KAVA 3WAWA 2XR9A 3M7VA 1Y6VA 3A52A 5INHA 4UOOA 4UOPA 1KH7A 3M8ZA 5L0BA 5C66A 1EI6A 2ANHA 4MHXA 3UNYA 5KXAA 1ALIA 3NKMA 3IGZB 5L0EA 3IDDA 4UPIA 2W5XA 2XRGA 3TX0A 4UPLA 5DLVA 3CMRA 4GTXA 5EGHA 5LIAA 5LRMA 3BDGB 4CXKA 3NKOA 3OT9A 4LQYA 2IFYA 1FSUA 5K4PA 3UN5A 1E3CP 3WAXA 1AJCA 1N2KA 1AJBA 3M8YA 3MK2A 3DPCA 4UORA 3T01A 4ZG9A 1E33P 3MK1A 3WAVA 1ED8A 1HDHA 4FDJA 4CXSA 4CYSA 2IUCB 4LRCA 2VQRA 3WBHA 3MK0A 3TWZA 2GA3A 2QZUA 4LRDA 4KM4A 3UO0A 4LRBA 3BDGA 3ED4A 4UPHA 4LRFA 2GSOA 5DLWA 2G9YA 5LQQA 1KH9A 4MIVA 1KHKA 4LR7A 1B8JA 1HQAA 2W5WA 3NVLA 4LR8A 4CXUA 3BDFA 3NKRA 2W5VA 3TG0A 1HJKA 2IUCA 4LREA 4ZGAA 2W5QA 1O98A 1KHLA 2W8DA 3T02A 1ED9A 4NWXA 4LR2A 2GLQA 5AJ9A 1EQJA 3T00A 4UPKA
chains in the Genus database with same CATH topology
5IJSA 1ALJA 1SHNA 1K7HA 1KH5A 1AJDA 1ZEBA 3Q3QA 1URAA 1EW8A 4LRAA 3M8WA 3SZYA 5EGEA 1EW9A 1ELYA 1ANJA 4CYRA 1ZEDA 3UN3A 1KHNA 4KAYA 1ANIA 4GTZA 1ZEFA 5DLTA 1N2LA 5IJQA 3BDHA 5TJ3A 3E2DA 4ZG7A 3DYCA 5HRTA 2RH6A 3NKQA 5GOVA 1ELXA 2ZKTA 3UN2A 1AJAA 4TN0A 1SHQA 4ZG6A 1ALKA 3NKNA 2W8SA 4NWJA 1KH4A 3IGYB 4FDIA 3KD8A 2W5SA 1O99A 2W5TA 2X98A 1URBA 1Y7AA 2D1GA 5L0KA 1E2SP 2W5RA 4GTWA 1EW2A 4MY4A 4LR9A 1AUKA 1ELZA 4N7TA 1EJJA 3LXQA 3B5QA 4QAXA 1ALHA 2GSNA 2GSUA 3SZZA 3WAYA 5LRNA 4KJGA 1P49A 4YR1A 3NKPA 4KJDA 4B56A 5GRRA 4GTYA 1E1ZP 1KHJA 4KAVA 3WAWA 2XR9A 3M7VA 1Y6VA 3A52A 5INHA 4UOOA 4UOPA 1KH7A 3M8ZA 5L0BA 5C66A 1EI6A 2ANHA 4MHXA 3UNYA 5KXAA 1ALIA 3NKMA 3IGZB 5L0EA 3IDDA 4UPIA 2W5XA 2XRGA 3TX0A 4UPLA 5DLVA 3CMRA 4GTXA 5EGHA 5LIAA 5LRMA 3BDGB 4CXKA 3NKOA 3OT9A 4LQYA 2IFYA 1FSUA 5K4PA 3UN5A 1E3CP 3WAXA 1AJCA 1N2KA 1AJBA 3M8YA 3MK2A 3DPCA 4UORA 3T01A 4ZG9A 1E33P 3MK1A 3WAVA 1ED8A 1HDHA 4FDJA 4CXSA 4CYSA 2IUCB 4LRCA 2VQRA 3WBHA 3MK0A 3TWZA 2GA3A 2QZUA 4LRDA 4KM4A 3UO0A 4LRBA 3BDGA 3ED4A 4UPHA 4LRFA 2GSOA 5DLWA 2G9YA 5LQQA 1KH9A 4MIVA 1KHKA 4LR7A 1B8JA 1HQAA 2W5WA 3NVLA 4LR8A 4CXUA 3BDFA 3NKRA 2W5VA 3TG0A 1HJKA 2IUCA 4LREA 4ZGAA 2W5QA 1O98A 1KHLA 2W8DA 3T02A 1ED9A 4NWXA 4LR2A 2GLQA 5AJ9A 1EQJA 3T00A 4UPKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5IJS A;  1ALJ A;  1SHN A;  1K7H A;  1KH5 A;  1AJD A;  1ZEB A;  3Q3Q A;  1URA A;  1EW8 A;  4LRA A;  3M8W A;  3SZY A;  5EGE A;  1EW9 A;  1ELY A;  1ANJ A;  4CYR A;  1ZED A;  3UN3 A;  1KHN A;  4KAY A;  1ANI A;  4GTZ A;  1ZEF A;  5DLT A;  1N2L A;  5IJQ A;  3BDH A;  5TJ3 A;  3E2D A;  4ZG7 A;  3DYC A;  5HRT A;  2RH6 A;  3NKQ A;  5GOV A;  1ELX A;  2ZKT A;  3UN2 A;  1AJA A;  4TN0 A;  1SHQ A;  4ZG6 A;  1ALK A;  3NKN A;  2W8S A;  4NWJ A;  1KH4 A;  3IGY B;  4FDI A;  3KD8 A;  2W5S A;  1O99 A;  2W5T A;  2X98 A;  1URB A;  1Y7A A;  2D1G A;  5L0K A;  1E2S P;  2W5R A;  4GTW A;  1EW2 A;  4MY4 A;  4LR9 A;  1AUK A;  1ELZ A;  4N7T A;  1EJJ A;  3LXQ A;  3B5Q A;  4QAX A;  1ALH A;  2GSN A;  2GSU A;  3SZZ A;  3WAY A;  5LRN A;  4KJG A;  1P49 A;  4YR1 A;  3NKP A;  4KJD A;  4B56 A;  5GRR A;  4GTY A;  1E1Z P;  1KHJ A;  4KAV A;  3WAW A;  2XR9 A;  3M7V A;  1Y6V A;  3A52 A;  5INH A;  4UOO A;  4UOP A;  1KH7 A;  3M8Z A;  5L0B A;  5C66 A;  1EI6 A;  2ANH A;  4MHX A;  3UNY A;  5KXA A;  1ALI A;  3NKM A;  3IGZ B;  5L0E A;  3IDD A;  4UPI A;  2W5X A;  2XRG A;  3TX0 A;  4UPL A;  5DLV A;  3CMR A;  4GTX A;  5EGH A;  5LIA A;  5LRM A;  3BDG B;  4CXK A;  3NKO A;  3OT9 A;  4LQY A;  2IFY A;  1FSU A;  5K4P A;  3UN5 A;  1E3C P;  3WAX A;  1AJC A;  1N2K A;  1AJB A;  3M8Y A;  3MK2 A;  3DPC A;  4UOR A;  3T01 A;  4ZG9 A;  1E33 P;  3MK1 A;  3WAV A;  1ED8 A;  1HDH A;  4FDJ A;  4CXS A;  4CYS A;  2IUC B;  4LRC A;  2VQR A;  3WBH A;  3MK0 A;  3TWZ A;  2GA3 A;  2QZU A;  4LRD A;  4KM4 A;  3UO0 A;  4LRB A;  3BDG A;  3ED4 A;  4UPH A;  4LRF A;  2GSO A;  5DLW A;  2G9Y A;  5LQQ A;  1KH9 A;  4MIV A;  1KHK A;  4LR7 A;  1B8J A;  1HQA A;  2W5W A;  3NVL A;  4LR8 A;  4CXU A;  3BDF A;  3NKR A;  2W5V A;  3TG0 A;  1HJK A;  2IUC A;  4LRE A;  4ZGA A;  2W5Q A;  1O98 A;  1KHL A;  2W8D A;  3T02 A;  1ED9 A;  4NWX A;  4LR2 A;  2GLQ A;  5AJ9 A;  1EQJ A;  3T00 A;  4UPK A; 
#chains in the Genus database with same CATH topology
 5IJS A;  1ALJ A;  1SHN A;  1K7H A;  1KH5 A;  1AJD A;  1ZEB A;  3Q3Q A;  1URA A;  1EW8 A;  4LRA A;  3M8W A;  3SZY A;  5EGE A;  1EW9 A;  1ELY A;  1ANJ A;  4CYR A;  1ZED A;  3UN3 A;  1KHN A;  4KAY A;  1ANI A;  4GTZ A;  1ZEF A;  5DLT A;  1N2L A;  5IJQ A;  3BDH A;  5TJ3 A;  3E2D A;  4ZG7 A;  3DYC A;  5HRT A;  2RH6 A;  3NKQ A;  5GOV A;  1ELX A;  2ZKT A;  3UN2 A;  1AJA A;  4TN0 A;  1SHQ A;  4ZG6 A;  1ALK A;  3NKN A;  2W8S A;  4NWJ A;  1KH4 A;  3IGY B;  4FDI A;  3KD8 A;  2W5S A;  1O99 A;  2W5T A;  2X98 A;  1URB A;  1Y7A A;  2D1G A;  5L0K A;  1E2S P;  2W5R A;  4GTW A;  1EW2 A;  4MY4 A;  4LR9 A;  1AUK A;  1ELZ A;  4N7T A;  1EJJ A;  3LXQ A;  3B5Q A;  4QAX A;  1ALH A;  2GSN A;  2GSU A;  3SZZ A;  3WAY A;  5LRN A;  4KJG A;  1P49 A;  4YR1 A;  3NKP A;  4KJD A;  4B56 A;  5GRR A;  4GTY A;  1E1Z P;  1KHJ A;  4KAV A;  3WAW A;  2XR9 A;  3M7V A;  1Y6V A;  3A52 A;  5INH A;  4UOO A;  4UOP A;  1KH7 A;  3M8Z A;  5L0B A;  5C66 A;  1EI6 A;  2ANH A;  4MHX A;  3UNY A;  5KXA A;  1ALI A;  3NKM A;  3IGZ B;  5L0E A;  3IDD A;  4UPI A;  2W5X A;  2XRG A;  3TX0 A;  4UPL A;  5DLV A;  3CMR A;  4GTX A;  5EGH A;  5LIA A;  5LRM A;  3BDG B;  4CXK A;  3NKO A;  3OT9 A;  4LQY A;  2IFY A;  1FSU A;  5K4P A;  3UN5 A;  1E3C P;  3WAX A;  1AJC A;  1N2K A;  1AJB A;  3M8Y A;  3MK2 A;  3DPC A;  4UOR A;  3T01 A;  4ZG9 A;  1E33 P;  3MK1 A;  3WAV A;  1ED8 A;  1HDH A;  4FDJ A;  4CXS A;  4CYS A;  2IUC B;  4LRC A;  2VQR A;  3WBH A;  3MK0 A;  3TWZ A;  2GA3 A;  2QZU A;  4LRD A;  4KM4 A;  3UO0 A;  4LRB A;  3BDG A;  3ED4 A;  4UPH A;  4LRF A;  2GSO A;  5DLW A;  2G9Y A;  5LQQ A;  1KH9 A;  4MIV A;  1KHK A;  4LR7 A;  1B8J A;  1HQA A;  2W5W A;  3NVL A;  4LR8 A;  4CXU A;  3BDF A;  3NKR A;  2W5V A;  3TG0 A;  1HJK A;  2IUC A;  4LRE A;  4ZGA A;  2W5Q A;  1O98 A;  1KHL A;  2W8D A;  3T02 A;  1ED9 A;  4NWX A;  4LR2 A;  2GLQ A;  5AJ9 A;  1EQJ A;  3T00 A;  4UPK A; 
#chains in the Genus database with same CATH homology
 5IJS A;  1ALJ A;  1SHN A;  1K7H A;  1KH5 A;  1AJD A;  1ZEB A;  3Q3Q A;  1URA A;  1EW8 A;  4LRA A;  3M8W A;  3SZY A;  5EGE A;  1EW9 A;  1ELY A;  1ANJ A;  4CYR A;  1ZED A;  3UN3 A;  1KHN A;  4KAY A;  1ANI A;  4GTZ A;  1ZEF A;  5DLT A;  1N2L A;  5IJQ A;  3BDH A;  5TJ3 A;  3E2D A;  4ZG7 A;  3DYC A;  5HRT A;  2RH6 A;  3NKQ A;  5GOV A;  1ELX A;  2ZKT A;  3UN2 A;  1AJA A;  4TN0 A;  1SHQ A;  4ZG6 A;  1ALK A;  3NKN A;  2W8S A;  4NWJ A;  1KH4 A;  3IGY B;  4FDI A;  3KD8 A;  2W5S A;  1O99 A;  2W5T A;  2X98 A;  1URB A;  1Y7A A;  2D1G A;  5L0K A;  1E2S P;  2W5R A;  4GTW A;  1EW2 A;  4MY4 A;  4LR9 A;  1AUK A;  1ELZ A;  4N7T A;  1EJJ A;  3LXQ A;  3B5Q A;  4QAX A;  1ALH A;  2GSN A;  2GSU A;  3SZZ A;  3WAY A;  5LRN A;  4KJG A;  1P49 A;  4YR1 A;  3NKP A;  4KJD A;  4B56 A;  5GRR A;  4GTY A;  1E1Z P;  1KHJ A;  4KAV A;  3WAW A;  2XR9 A;  3M7V A;  1Y6V A;  3A52 A;  5INH A;  4UOO A;  4UOP A;  1KH7 A;  3M8Z A;  5L0B A;  5C66 A;  1EI6 A;  2ANH A;  4MHX A;  3UNY A;  5KXA A;  1ALI A;  3NKM A;  3IGZ B;  5L0E A;  3IDD A;  4UPI A;  2W5X A;  2XRG A;  3TX0 A;  4UPL A;  5DLV A;  3CMR A;  4GTX A;  5EGH A;  5LIA A;  5LRM A;  3BDG B;  4CXK A;  3NKO A;  3OT9 A;  4LQY A;  2IFY A;  1FSU A;  5K4P A;  3UN5 A;  1E3C P;  3WAX A;  1AJC A;  1N2K A;  1AJB A;  3M8Y A;  3MK2 A;  3DPC A;  4UOR A;  3T01 A;  4ZG9 A;  1E33 P;  3MK1 A;  3WAV A;  1ED8 A;  1HDH A;  4FDJ A;  4CXS A;  4CYS A;  2IUC B;  4LRC A;  2VQR A;  3WBH A;  3MK0 A;  3TWZ A;  2GA3 A;  2QZU A;  4LRD A;  4KM4 A;  3UO0 A;  4LRB A;  3BDG A;  3ED4 A;  4UPH A;  4LRF A;  2GSO A;  5DLW A;  2G9Y A;  5LQQ A;  1KH9 A;  4MIV A;  1KHK A;  4LR7 A;  1B8J A;  1HQA A;  2W5W A;  3NVL A;  4LR8 A;  4CXU A;  3BDF A;  3NKR A;  2W5V A;  3TG0 A;  1HJK A;  2IUC A;  4LRE A;  4ZGA A;  2W5Q A;  1O98 A;  1KHL A;  2W8D A;  3T02 A;  1ED9 A;  4NWX A;  4LR2 A;  2GLQ A;  5AJ9 A;  1EQJ A;  3T00 A;  4UPK A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...