1ALIA

Alkaline phosphatase mutant (h412n)
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQENTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Escherichia coli alkaline phosphatase: X-ray structural studies of a mutant enzyme (His-412-->Asn) at one of the catalytically important zinc binding sites.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolase (phosphoric monoester)
total genus 162
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1aliA00
1Y7AA 4MIVA 4UPIA 3BDGA 3DPCA 3NKOA 4GTXA 3BDHA 3OT9A 3MK1A 1E33P 1P49A 2W5XA 3B5QA 1KH4A 3NKQA 4FDJA 3Q3QA 3SZZA 3TX0A 1ZEFA 4ZG7A 4UPLA 3IGYB 1ELXA 1URBA 4ZGAA 5LRNA 1ED9A 3WAWA 1ELZA 4LRDA 3ED4A 1N2LA 4FDIA 1ZEDA 2IFYA 1KH5A 5K4PA 4LREA 2VQRA 2GA3A 4LR9A 2W5TA 3UN2A 5GRRA 5LQQA 3E2DA 4QAXA 1EQJA 2XR9A 2ANHA 4MY4A 1E1ZP 1AJBA 4KJGA 4UPKA 5C66A 2QZUA 1EW8A 1Y6VA 2W8SA 3WBHA 1EW2A 4KAVA 5IJSA 2G9YA 5L0EA 2W8DA 1KH7A 4KAYA 3M8ZA 3IGZB 4GTZA 5L0KA 3WAYA 3T00A 2GSNA 5AJ9A 5KXAA 3CMRA 1E3CP 3M7VA 4KM4A 4LR7A 4LRFA 1E2SP 2W5QA 2IUCB 4ZG9A 2IUCA 4LRBA 4MHXA 5DLWA 1KHNA 2GSUA 4UORA 4CYRA 3TWZA 3KD8A 3SZYA 1AJDA 3DYCA 3NKPA 4UOPA 5IJQA 3MK2A 1N2KA 5GOVA 4CXUA 4TN0A 3UN3A 1AJAA 4ZG6A 1FSUA 1AUKA 3IDDA 5HRTA 5EGHA 1O99A 3M8WA 1K7HA 4UOOA 3T01A 1ELYA 1HQAA 1URAA 1EI6A 1SHNA 1EW9A 1KHKA 3NKRA 1AJCA 4LR2A 2W5SA 3T02A 1ZEBA 3NKMA 2GSOA 2RH6A 2GLQA 1ALHA 3BDFA 5TJ3A 1B8JA 2W5VA 4LRAA 4LRCA 3TG0A 1ANJA 4KJDA 1ED8A 2ZKTA 4CYSA 2W5RA 2XRGA 1KHJA 2W5WA 1ANIA 4CXKA 1KHLA 1EJJA 3WAVA 1HDHA 1O98A 4N7TA 5EGEA 3M8YA 3UN5A 5LRMA 5INHA 4NWXA 3UO0A 5L0BA 3UNYA 5DLTA 3MK0A 4NWJA 4CXSA 3A52A 4LR8A 4GTWA 1ALKA 1SHQA 1KH9A 4LQYA 3WAXA 4B56A 4YR1A 4GTYA 3NVLA 2D1GA 1ALJA 1HJKA 3NKNA 5LIAA 4UPHA 5DLVA 2X98A 1ALIA 3LXQA 3BDGB
chains in the Genus database with same CATH superfamily
1Y7AA 4MIVA 4UPIA 3BDGA 3DPCA 3NKOA 4GTXA 3BDHA 3OT9A 3MK1A 1E33P 1P49A 2W5XA 3B5QA 1KH4A 3NKQA 4FDJA 3Q3QA 3SZZA 3TX0A 1ZEFA 4ZG7A 4UPLA 3IGYB 1ELXA 1URBA 4ZGAA 5LRNA 1ED9A 3WAWA 1ELZA 4LRDA 3ED4A 1N2LA 4FDIA 1ZEDA 2IFYA 1KH5A 5K4PA 4LREA 2VQRA 2GA3A 4LR9A 2W5TA 3UN2A 5GRRA 5LQQA 3E2DA 4QAXA 1EQJA 2XR9A 2ANHA 4MY4A 1E1ZP 1AJBA 4KJGA 4UPKA 5C66A 2QZUA 1EW8A 1Y6VA 2W8SA 3WBHA 1EW2A 4KAVA 5IJSA 2G9YA 5L0EA 2W8DA 1KH7A 4KAYA 3M8ZA 3IGZB 4GTZA 5L0KA 3WAYA 3T00A 2GSNA 5AJ9A 5KXAA 3CMRA 1E3CP 3M7VA 4KM4A 4LR7A 4LRFA 1E2SP 2W5QA 2IUCB 4ZG9A 2IUCA 4LRBA 4MHXA 5DLWA 1KHNA 2GSUA 4UORA 4CYRA 3TWZA 3KD8A 3SZYA 1AJDA 3DYCA 3NKPA 4UOPA 5IJQA 3MK2A 1N2KA 5GOVA 4CXUA 4TN0A 3UN3A 1AJAA 4ZG6A 1FSUA 1AUKA 3IDDA 5HRTA 5EGHA 1O99A 3M8WA 1K7HA 4UOOA 3T01A 1ELYA 1HQAA 1URAA 1EI6A 1SHNA 1EW9A 1KHKA 3NKRA 1AJCA 4LR2A 2W5SA 3T02A 1ZEBA 3NKMA 2GSOA 2RH6A 2GLQA 1ALHA 3BDFA 5TJ3A 1B8JA 2W5VA 4LRAA 4LRCA 3TG0A 1ANJA 4KJDA 1ED8A 2ZKTA 4CYSA 2W5RA 2XRGA 1KHJA 2W5WA 1ANIA 4CXKA 1KHLA 1EJJA 3WAVA 1HDHA 1O98A 4N7TA 5EGEA 3M8YA 3UN5A 5LRMA 5INHA 4NWXA 3UO0A 5L0BA 3UNYA 5DLTA 3MK0A 4NWJA 4CXSA 3A52A 4LR8A 4GTWA 1ALKA 1SHQA 1KH9A 4LQYA 3WAXA 4B56A 4YR1A 4GTYA 3NVLA 2D1GA 1ALJA 1HJKA 3NKNA 5LIAA 4UPHA 5DLVA 2X98A 1ALIA 3LXQA 3BDGB
chains in the Genus database with same CATH topology
1Y7AA 4MIVA 4UPIA 3BDGA 3DPCA 3NKOA 4GTXA 3BDHA 3OT9A 3MK1A 1E33P 1P49A 2W5XA 3B5QA 1KH4A 3NKQA 4FDJA 3Q3QA 3SZZA 3TX0A 1ZEFA 4ZG7A 4UPLA 3IGYB 1ELXA 1URBA 4ZGAA 5LRNA 1ED9A 3WAWA 1ELZA 4LRDA 3ED4A 1N2LA 4FDIA 1ZEDA 2IFYA 1KH5A 5K4PA 4LREA 2VQRA 2GA3A 4LR9A 2W5TA 3UN2A 5GRRA 5LQQA 3E2DA 4QAXA 1EQJA 2XR9A 2ANHA 4MY4A 1E1ZP 1AJBA 4KJGA 4UPKA 5C66A 2QZUA 1EW8A 1Y6VA 2W8SA 3WBHA 1EW2A 4KAVA 5IJSA 2G9YA 5L0EA 2W8DA 1KH7A 4KAYA 3M8ZA 3IGZB 4GTZA 5L0KA 3WAYA 3T00A 2GSNA 5AJ9A 5KXAA 3CMRA 1E3CP 3M7VA 4KM4A 4LR7A 4LRFA 1E2SP 2W5QA 2IUCB 4ZG9A 2IUCA 4LRBA 4MHXA 5DLWA 1KHNA 2GSUA 4UORA 4CYRA 3TWZA 3KD8A 3SZYA 1AJDA 3DYCA 3NKPA 4UOPA 5IJQA 3MK2A 1N2KA 5GOVA 4CXUA 4TN0A 3UN3A 1AJAA 4ZG6A 1FSUA 1AUKA 3IDDA 5HRTA 5EGHA 1O99A 3M8WA 1K7HA 4UOOA 3T01A 1ELYA 1HQAA 1URAA 1EI6A 1SHNA 1EW9A 1KHKA 3NKRA 1AJCA 4LR2A 2W5SA 3T02A 1ZEBA 3NKMA 2GSOA 2RH6A 2GLQA 1ALHA 3BDFA 5TJ3A 1B8JA 2W5VA 4LRAA 4LRCA 3TG0A 1ANJA 4KJDA 1ED8A 2ZKTA 4CYSA 2W5RA 2XRGA 1KHJA 2W5WA 1ANIA 4CXKA 1KHLA 1EJJA 3WAVA 1HDHA 1O98A 4N7TA 5EGEA 3M8YA 3UN5A 5LRMA 5INHA 4NWXA 3UO0A 5L0BA 3UNYA 5DLTA 3MK0A 4NWJA 4CXSA 3A52A 4LR8A 4GTWA 1ALKA 1SHQA 1KH9A 4LQYA 3WAXA 4B56A 4YR1A 4GTYA 3NVLA 2D1GA 1ALJA 1HJKA 3NKNA 5LIAA 4UPHA 5DLVA 2X98A 1ALIA 3LXQA 3BDGB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Y7A A;  4MIV A;  4UPI A;  3BDG A;  3DPC A;  3NKO A;  4GTX A;  3BDH A;  3OT9 A;  3MK1 A;  1E33 P;  1P49 A;  2W5X A;  3B5Q A;  1KH4 A;  3NKQ A;  4FDJ A;  3Q3Q A;  3SZZ A;  3TX0 A;  1ZEF A;  4ZG7 A;  4UPL A;  3IGY B;  1ELX A;  1URB A;  4ZGA A;  5LRN A;  1ED9 A;  3WAW A;  1ELZ A;  4LRD A;  3ED4 A;  1N2L A;  4FDI A;  1ZED A;  2IFY A;  1KH5 A;  5K4P A;  4LRE A;  2VQR A;  2GA3 A;  4LR9 A;  2W5T A;  3UN2 A;  5GRR A;  5LQQ A;  3E2D A;  4QAX A;  1EQJ A;  2XR9 A;  2ANH A;  4MY4 A;  1E1Z P;  1AJB A;  4KJG A;  4UPK A;  5C66 A;  2QZU A;  1EW8 A;  1Y6V A;  2W8S A;  3WBH A;  1EW2 A;  4KAV A;  5IJS A;  2G9Y A;  5L0E A;  2W8D A;  1KH7 A;  4KAY A;  3M8Z A;  3IGZ B;  4GTZ A;  5L0K A;  3WAY A;  3T00 A;  2GSN A;  5AJ9 A;  5KXA A;  3CMR A;  1E3C P;  3M7V A;  4KM4 A;  4LR7 A;  4LRF A;  1E2S P;  2W5Q A;  2IUC B;  4ZG9 A;  2IUC A;  4LRB A;  4MHX A;  5DLW A;  1KHN A;  2GSU A;  4UOR A;  4CYR A;  3TWZ A;  3KD8 A;  3SZY A;  1AJD A;  3DYC A;  3NKP A;  4UOP A;  5IJQ A;  3MK2 A;  1N2K A;  5GOV A;  4CXU A;  4TN0 A;  3UN3 A;  1AJA A;  4ZG6 A;  1FSU A;  1AUK A;  3IDD A;  5HRT A;  5EGH A;  1O99 A;  3M8W A;  1K7H A;  4UOO A;  3T01 A;  1ELY A;  1HQA A;  1URA A;  1EI6 A;  1SHN A;  1EW9 A;  1KHK A;  3NKR A;  1AJC A;  4LR2 A;  2W5S A;  3T02 A;  1ZEB A;  3NKM A;  2GSO A;  2RH6 A;  2GLQ A;  1ALH A;  3BDF A;  5TJ3 A;  1B8J A;  2W5V A;  4LRA A;  4LRC A;  3TG0 A;  1ANJ A;  4KJD A;  1ED8 A;  2ZKT A;  4CYS A;  2W5R A;  2XRG A;  1KHJ A;  2W5W A;  1ANI A;  4CXK A;  1KHL A;  1EJJ A;  3WAV A;  1HDH A;  1O98 A;  4N7T A;  5EGE A;  3M8Y A;  3UN5 A;  5LRM A;  5INH A;  4NWX A;  3UO0 A;  5L0B A;  3UNY A;  5DLT A;  3MK0 A;  4NWJ A;  4CXS A;  3A52 A;  4LR8 A;  4GTW A;  1ALK A;  1SHQ A;  1KH9 A;  4LQY A;  3WAX A;  4B56 A;  4YR1 A;  4GTY A;  3NVL A;  2D1G A;  1ALJ A;  1HJK A;  3NKN A;  5LIA A;  4UPH A;  5DLV A;  2X98 A;  1ALI A;  3LXQ A;  3BDG B; 
#chains in the Genus database with same CATH topology
 1Y7A A;  4MIV A;  4UPI A;  3BDG A;  3DPC A;  3NKO A;  4GTX A;  3BDH A;  3OT9 A;  3MK1 A;  1E33 P;  1P49 A;  2W5X A;  3B5Q A;  1KH4 A;  3NKQ A;  4FDJ A;  3Q3Q A;  3SZZ A;  3TX0 A;  1ZEF A;  4ZG7 A;  4UPL A;  3IGY B;  1ELX A;  1URB A;  4ZGA A;  5LRN A;  1ED9 A;  3WAW A;  1ELZ A;  4LRD A;  3ED4 A;  1N2L A;  4FDI A;  1ZED A;  2IFY A;  1KH5 A;  5K4P A;  4LRE A;  2VQR A;  2GA3 A;  4LR9 A;  2W5T A;  3UN2 A;  5GRR A;  5LQQ A;  3E2D A;  4QAX A;  1EQJ A;  2XR9 A;  2ANH A;  4MY4 A;  1E1Z P;  1AJB A;  4KJG A;  4UPK A;  5C66 A;  2QZU A;  1EW8 A;  1Y6V A;  2W8S A;  3WBH A;  1EW2 A;  4KAV A;  5IJS A;  2G9Y A;  5L0E A;  2W8D A;  1KH7 A;  4KAY A;  3M8Z A;  3IGZ B;  4GTZ A;  5L0K A;  3WAY A;  3T00 A;  2GSN A;  5AJ9 A;  5KXA A;  3CMR A;  1E3C P;  3M7V A;  4KM4 A;  4LR7 A;  4LRF A;  1E2S P;  2W5Q A;  2IUC B;  4ZG9 A;  2IUC A;  4LRB A;  4MHX A;  5DLW A;  1KHN A;  2GSU A;  4UOR A;  4CYR A;  3TWZ A;  3KD8 A;  3SZY A;  1AJD A;  3DYC A;  3NKP A;  4UOP A;  5IJQ A;  3MK2 A;  1N2K A;  5GOV A;  4CXU A;  4TN0 A;  3UN3 A;  1AJA A;  4ZG6 A;  1FSU A;  1AUK A;  3IDD A;  5HRT A;  5EGH A;  1O99 A;  3M8W A;  1K7H A;  4UOO A;  3T01 A;  1ELY A;  1HQA A;  1URA A;  1EI6 A;  1SHN A;  1EW9 A;  1KHK A;  3NKR A;  1AJC A;  4LR2 A;  2W5S A;  3T02 A;  1ZEB A;  3NKM A;  2GSO A;  2RH6 A;  2GLQ A;  1ALH A;  3BDF A;  5TJ3 A;  1B8J A;  2W5V A;  4LRA A;  4LRC A;  3TG0 A;  1ANJ A;  4KJD A;  1ED8 A;  2ZKT A;  4CYS A;  2W5R A;  2XRG A;  1KHJ A;  2W5W A;  1ANI A;  4CXK A;  1KHL A;  1EJJ A;  3WAV A;  1HDH A;  1O98 A;  4N7T A;  5EGE A;  3M8Y A;  3UN5 A;  5LRM A;  5INH A;  4NWX A;  3UO0 A;  5L0B A;  3UNY A;  5DLT A;  3MK0 A;  4NWJ A;  4CXS A;  3A52 A;  4LR8 A;  4GTW A;  1ALK A;  1SHQ A;  1KH9 A;  4LQY A;  3WAX A;  4B56 A;  4YR1 A;  4GTY A;  3NVL A;  2D1G A;  1ALJ A;  1HJK A;  3NKN A;  5LIA A;  4UPH A;  5DLV A;  2X98 A;  1ALI A;  3LXQ A;  3BDG B; 
#chains in the Genus database with same CATH homology
 1Y7A A;  4MIV A;  4UPI A;  3BDG A;  3DPC A;  3NKO A;  4GTX A;  3BDH A;  3OT9 A;  3MK1 A;  1E33 P;  1P49 A;  2W5X A;  3B5Q A;  1KH4 A;  3NKQ A;  4FDJ A;  3Q3Q A;  3SZZ A;  3TX0 A;  1ZEF A;  4ZG7 A;  4UPL A;  3IGY B;  1ELX A;  1URB A;  4ZGA A;  5LRN A;  1ED9 A;  3WAW A;  1ELZ A;  4LRD A;  3ED4 A;  1N2L A;  4FDI A;  1ZED A;  2IFY A;  1KH5 A;  5K4P A;  4LRE A;  2VQR A;  2GA3 A;  4LR9 A;  2W5T A;  3UN2 A;  5GRR A;  5LQQ A;  3E2D A;  4QAX A;  1EQJ A;  2XR9 A;  2ANH A;  4MY4 A;  1E1Z P;  1AJB A;  4KJG A;  4UPK A;  5C66 A;  2QZU A;  1EW8 A;  1Y6V A;  2W8S A;  3WBH A;  1EW2 A;  4KAV A;  5IJS A;  2G9Y A;  5L0E A;  2W8D A;  1KH7 A;  4KAY A;  3M8Z A;  3IGZ B;  4GTZ A;  5L0K A;  3WAY A;  3T00 A;  2GSN A;  5AJ9 A;  5KXA A;  3CMR A;  1E3C P;  3M7V A;  4KM4 A;  4LR7 A;  4LRF A;  1E2S P;  2W5Q A;  2IUC B;  4ZG9 A;  2IUC A;  4LRB A;  4MHX A;  5DLW A;  1KHN A;  2GSU A;  4UOR A;  4CYR A;  3TWZ A;  3KD8 A;  3SZY A;  1AJD A;  3DYC A;  3NKP A;  4UOP A;  5IJQ A;  3MK2 A;  1N2K A;  5GOV A;  4CXU A;  4TN0 A;  3UN3 A;  1AJA A;  4ZG6 A;  1FSU A;  1AUK A;  3IDD A;  5HRT A;  5EGH A;  1O99 A;  3M8W A;  1K7H A;  4UOO A;  3T01 A;  1ELY A;  1HQA A;  1URA A;  1EI6 A;  1SHN A;  1EW9 A;  1KHK A;  3NKR A;  1AJC A;  4LR2 A;  2W5S A;  3T02 A;  1ZEB A;  3NKM A;  2GSO A;  2RH6 A;  2GLQ A;  1ALH A;  3BDF A;  5TJ3 A;  1B8J A;  2W5V A;  4LRA A;  4LRC A;  3TG0 A;  1ANJ A;  4KJD A;  1ED8 A;  2ZKT A;  4CYS A;  2W5R A;  2XRG A;  1KHJ A;  2W5W A;  1ANI A;  4CXK A;  1KHL A;  1EJJ A;  3WAV A;  1HDH A;  1O98 A;  4N7T A;  5EGE A;  3M8Y A;  3UN5 A;  5LRM A;  5INH A;  4NWX A;  3UO0 A;  5L0B A;  3UNY A;  5DLT A;  3MK0 A;  4NWJ A;  4CXS A;  3A52 A;  4LR8 A;  4GTW A;  1ALK A;  1SHQ A;  1KH9 A;  4LQY A;  3WAX A;  4B56 A;  4YR1 A;  4GTY A;  3NVL A;  2D1G A;  1ALJ A;  1HJK A;  3NKN A;  5LIA A;  4UPH A;  5DLV A;  2X98 A;  1ALI A;  3LXQ A;  3BDG B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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