1ALIA

Alkaline phosphatase mutant (h412n)
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQENTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Escherichia coli alkaline phosphatase: X-ray structural studies of a mutant enzyme (His-412-->Asn) at one of the catalytically important zinc binding sites.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolase (phosphoric monoester)
molecule keywords ALKALINE PHOSPHATASE
total genus 162
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1aliA00
4ZG7A 3DPCA 2GLQA 3M8YA 1KHKA 2W5VA 5GOVA 3A52A 5INHA 4UOPA 3WAXA 3SZYA 2IUCA 1KHNA 3UO0A 3M8ZA 4UPIA 2W8SA 3NKPA 4LRDA 1P49A 2IFYA 3BDFA 1Y6VA 1ANJA 1ED8A 3NKRA 3BDGA 4LREA 1ZEBA 4UPKA 3MK1A 4UORA 1E2SP 1EW9A 2W5WA 5DLTA 1ELYA 5LRNA 4UOOA 1AJCA 1KH5A 1KHJA 1ZEDA 3LXQA 5IJSA 4GTYA 3MK0A 3NKNA 4CXSA 3DYCA 2W8DA 3TG0A 4LRCA 5GRRA 2XRGA 5L0EA 4GTXA 2W5XA 5LQQA 4ZG6A 5DLVA 4LR7A 3IDDA 5LIAA 1ELXA 1ALKA 2GA3A 1AJAA 1N2LA 3ED4A 4LRBA 1ELZA 1N2KA 3E2DA 1ED9A 3UNYA 4UPLA 1Y7AA 4FDIA 2XR9A 4N7TA 5C66A 3T02A 5DLWA 3UN2A 2GSNA 1EQJA 1URBA 4LR8A 2W5QA 4FDJA 3WBHA 1E1ZP 4CXUA 1ALHA 3TWZA 4KAYA 5EGHA 2RH6A 4NWJA 4LRAA 3CMRA 1ALJA 3Q3QA 1URAA 5AJ9A 3TX0A 3IGZB 2IUCB 1SHNA 3NKQA 1KHLA 4LRFA 4MIVA 1E3CP 3T01A 5L0BA 3UN3A 2W5SA 4CYSA 4LR2A 1AJBA 4LQYA 4KAVA 1KH4A 4CYRA 1K7HA 4KJGA 4ZG9A 4QAXA 2GSOA 2ZKTA 3T00A 2QZUA 3BDGB 4LR9A 1HJKA 1O99A 3NKMA 1E33P 2G9YA 1B8JA 3MK2A 3WAWA 5KXAA 5LRMA 1EI6A 1KH9A 1AUKA 2ANHA 5L0KA 4GTZA 4ZGAA 4TN0A 4KJDA 4CXKA 1FSUA 2GSUA 1EW2A 2W5RA 1ALIA 4UPHA 5K4PA 3NVLA 2VQRA 1ZEFA 3M8WA 4B56A 4KM4A 1EJJA 3OT9A 1AJDA 1KH7A 4GTWA 5EGEA 5IJQA 3SZZA 4MHXA 3KD8A 2X98A 3B5QA 3M7VA 1HDHA 3IGYB 4NWXA 3WAVA 1EW8A 1O98A 5HRTA 3WAYA 1ANIA 4YR1A 2W5TA 4MY4A 3UN5A 5TJ3A 1HQAA 3BDHA 3NKOA 2D1GA 1SHQA
chains in the Genus database with same CATH superfamily
4ZG7A 3DPCA 2GLQA 3M8YA 1KHKA 2W5VA 5GOVA 3A52A 5INHA 4UOPA 3WAXA 3SZYA 2IUCA 1KHNA 3UO0A 3M8ZA 4UPIA 2W8SA 3NKPA 4LRDA 1P49A 2IFYA 3BDFA 1Y6VA 1ANJA 1ED8A 3NKRA 3BDGA 4LREA 1ZEBA 4UPKA 3MK1A 4UORA 1E2SP 1EW9A 2W5WA 5DLTA 1ELYA 5LRNA 4UOOA 1AJCA 1KH5A 1KHJA 1ZEDA 3LXQA 5IJSA 4GTYA 3MK0A 3NKNA 4CXSA 3DYCA 2W8DA 3TG0A 4LRCA 5GRRA 2XRGA 5L0EA 4GTXA 2W5XA 5LQQA 4ZG6A 5DLVA 4LR7A 3IDDA 5LIAA 1ELXA 1ALKA 2GA3A 1AJAA 1N2LA 3ED4A 4LRBA 1ELZA 1N2KA 3E2DA 1ED9A 3UNYA 4UPLA 1Y7AA 4FDIA 2XR9A 4N7TA 5C66A 3T02A 5DLWA 3UN2A 2GSNA 1EQJA 1URBA 4LR8A 2W5QA 4FDJA 3WBHA 1E1ZP 4CXUA 1ALHA 3TWZA 4KAYA 5EGHA 2RH6A 4NWJA 4LRAA 3CMRA 1ALJA 3Q3QA 1URAA 5AJ9A 3TX0A 3IGZB 2IUCB 1SHNA 3NKQA 1KHLA 4LRFA 4MIVA 1E3CP 3T01A 5L0BA 3UN3A 2W5SA 4CYSA 4LR2A 1AJBA 4LQYA 4KAVA 1KH4A 4CYRA 1K7HA 4KJGA 4ZG9A 4QAXA 2GSOA 2ZKTA 3T00A 2QZUA 3BDGB 4LR9A 1HJKA 1O99A 3NKMA 1E33P 2G9YA 1B8JA 3MK2A 3WAWA 5KXAA 5LRMA 1EI6A 1KH9A 1AUKA 2ANHA 5L0KA 4GTZA 4ZGAA 4TN0A 4KJDA 4CXKA 1FSUA 2GSUA 1EW2A 2W5RA 1ALIA 4UPHA 5K4PA 3NVLA 2VQRA 1ZEFA 3M8WA 4B56A 4KM4A 1EJJA 3OT9A 1AJDA 1KH7A 4GTWA 5EGEA 5IJQA 3SZZA 4MHXA 3KD8A 2X98A 3B5QA 3M7VA 1HDHA 3IGYB 4NWXA 3WAVA 1EW8A 1O98A 5HRTA 3WAYA 1ANIA 4YR1A 2W5TA 4MY4A 3UN5A 5TJ3A 1HQAA 3BDHA 3NKOA 2D1GA 1SHQA
chains in the Genus database with same CATH topology
4ZG7A 3DPCA 2GLQA 3M8YA 1KHKA 2W5VA 5GOVA 3A52A 5INHA 4UOPA 3WAXA 3SZYA 2IUCA 1KHNA 3UO0A 3M8ZA 4UPIA 2W8SA 3NKPA 4LRDA 1P49A 2IFYA 3BDFA 1Y6VA 1ANJA 1ED8A 3NKRA 3BDGA 4LREA 1ZEBA 4UPKA 3MK1A 4UORA 1E2SP 1EW9A 2W5WA 5DLTA 1ELYA 5LRNA 4UOOA 1AJCA 1KH5A 1KHJA 1ZEDA 3LXQA 5IJSA 4GTYA 3MK0A 3NKNA 4CXSA 3DYCA 2W8DA 3TG0A 4LRCA 5GRRA 2XRGA 5L0EA 4GTXA 2W5XA 5LQQA 4ZG6A 5DLVA 4LR7A 3IDDA 5LIAA 1ELXA 1ALKA 2GA3A 1AJAA 1N2LA 3ED4A 4LRBA 1ELZA 1N2KA 3E2DA 1ED9A 3UNYA 4UPLA 1Y7AA 4FDIA 2XR9A 4N7TA 5C66A 3T02A 5DLWA 3UN2A 2GSNA 1EQJA 1URBA 4LR8A 2W5QA 4FDJA 3WBHA 1E1ZP 4CXUA 1ALHA 3TWZA 4KAYA 5EGHA 2RH6A 4NWJA 4LRAA 3CMRA 1ALJA 3Q3QA 1URAA 5AJ9A 3TX0A 3IGZB 2IUCB 1SHNA 3NKQA 1KHLA 4LRFA 4MIVA 1E3CP 3T01A 5L0BA 3UN3A 2W5SA 4CYSA 4LR2A 1AJBA 4LQYA 4KAVA 1KH4A 4CYRA 1K7HA 4KJGA 4ZG9A 4QAXA 2GSOA 2ZKTA 3T00A 2QZUA 3BDGB 4LR9A 1HJKA 1O99A 3NKMA 1E33P 2G9YA 1B8JA 3MK2A 3WAWA 5KXAA 5LRMA 1EI6A 1KH9A 1AUKA 2ANHA 5L0KA 4GTZA 4ZGAA 4TN0A 4KJDA 4CXKA 1FSUA 2GSUA 1EW2A 2W5RA 1ALIA 4UPHA 5K4PA 3NVLA 2VQRA 1ZEFA 3M8WA 4B56A 4KM4A 1EJJA 3OT9A 1AJDA 1KH7A 4GTWA 5EGEA 5IJQA 3SZZA 4MHXA 3KD8A 2X98A 3B5QA 3M7VA 1HDHA 3IGYB 4NWXA 3WAVA 1EW8A 1O98A 5HRTA 3WAYA 1ANIA 4YR1A 2W5TA 4MY4A 3UN5A 5TJ3A 1HQAA 3BDHA 3NKOA 2D1GA 1SHQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZG7 A;  3DPC A;  2GLQ A;  3M8Y A;  1KHK A;  2W5V A;  5GOV A;  3A52 A;  5INH A;  4UOP A;  3WAX A;  3SZY A;  2IUC A;  1KHN A;  3UO0 A;  3M8Z A;  4UPI A;  2W8S A;  3NKP A;  4LRD A;  1P49 A;  2IFY A;  3BDF A;  1Y6V A;  1ANJ A;  1ED8 A;  3NKR A;  3BDG A;  4LRE A;  1ZEB A;  4UPK A;  3MK1 A;  4UOR A;  1E2S P;  1EW9 A;  2W5W A;  5DLT A;  1ELY A;  5LRN A;  4UOO A;  1AJC A;  1KH5 A;  1KHJ A;  1ZED A;  3LXQ A;  5IJS A;  4GTY A;  3MK0 A;  3NKN A;  4CXS A;  3DYC A;  2W8D A;  3TG0 A;  4LRC A;  5GRR A;  2XRG A;  5L0E A;  4GTX A;  2W5X A;  5LQQ A;  4ZG6 A;  5DLV A;  4LR7 A;  3IDD A;  5LIA A;  1ELX A;  1ALK A;  2GA3 A;  1AJA A;  1N2L A;  3ED4 A;  4LRB A;  1ELZ A;  1N2K A;  3E2D A;  1ED9 A;  3UNY A;  4UPL A;  1Y7A A;  4FDI A;  2XR9 A;  4N7T A;  5C66 A;  3T02 A;  5DLW A;  3UN2 A;  2GSN A;  1EQJ A;  1URB A;  4LR8 A;  2W5Q A;  4FDJ A;  3WBH A;  1E1Z P;  4CXU A;  1ALH A;  3TWZ A;  4KAY A;  5EGH A;  2RH6 A;  4NWJ A;  4LRA A;  3CMR A;  1ALJ A;  3Q3Q A;  1URA A;  5AJ9 A;  3TX0 A;  3IGZ B;  2IUC B;  1SHN A;  3NKQ A;  1KHL A;  4LRF A;  4MIV A;  1E3C P;  3T01 A;  5L0B A;  3UN3 A;  2W5S A;  4CYS A;  4LR2 A;  1AJB A;  4LQY A;  4KAV A;  1KH4 A;  4CYR A;  1K7H A;  4KJG A;  4ZG9 A;  4QAX A;  2GSO A;  2ZKT A;  3T00 A;  2QZU A;  3BDG B;  4LR9 A;  1HJK A;  1O99 A;  3NKM A;  1E33 P;  2G9Y A;  1B8J A;  3MK2 A;  3WAW A;  5KXA A;  5LRM A;  1EI6 A;  1KH9 A;  1AUK A;  2ANH A;  5L0K A;  4GTZ A;  4ZGA A;  4TN0 A;  4KJD A;  4CXK A;  1FSU A;  2GSU A;  1EW2 A;  2W5R A;  1ALI A;  4UPH A;  5K4P A;  3NVL A;  2VQR A;  1ZEF A;  3M8W A;  4B56 A;  4KM4 A;  1EJJ A;  3OT9 A;  1AJD A;  1KH7 A;  4GTW A;  5EGE A;  5IJQ A;  3SZZ A;  4MHX A;  3KD8 A;  2X98 A;  3B5Q A;  3M7V A;  1HDH A;  3IGY B;  4NWX A;  3WAV A;  1EW8 A;  1O98 A;  5HRT A;  3WAY A;  1ANI A;  4YR1 A;  2W5T A;  4MY4 A;  3UN5 A;  5TJ3 A;  1HQA A;  3BDH A;  3NKO A;  2D1G A;  1SHQ A; 
#chains in the Genus database with same CATH topology
 4ZG7 A;  3DPC A;  2GLQ A;  3M8Y A;  1KHK A;  2W5V A;  5GOV A;  3A52 A;  5INH A;  4UOP A;  3WAX A;  3SZY A;  2IUC A;  1KHN A;  3UO0 A;  3M8Z A;  4UPI A;  2W8S A;  3NKP A;  4LRD A;  1P49 A;  2IFY A;  3BDF A;  1Y6V A;  1ANJ A;  1ED8 A;  3NKR A;  3BDG A;  4LRE A;  1ZEB A;  4UPK A;  3MK1 A;  4UOR A;  1E2S P;  1EW9 A;  2W5W A;  5DLT A;  1ELY A;  5LRN A;  4UOO A;  1AJC A;  1KH5 A;  1KHJ A;  1ZED A;  3LXQ A;  5IJS A;  4GTY A;  3MK0 A;  3NKN A;  4CXS A;  3DYC A;  2W8D A;  3TG0 A;  4LRC A;  5GRR A;  2XRG A;  5L0E A;  4GTX A;  2W5X A;  5LQQ A;  4ZG6 A;  5DLV A;  4LR7 A;  3IDD A;  5LIA A;  1ELX A;  1ALK A;  2GA3 A;  1AJA A;  1N2L A;  3ED4 A;  4LRB A;  1ELZ A;  1N2K A;  3E2D A;  1ED9 A;  3UNY A;  4UPL A;  1Y7A A;  4FDI A;  2XR9 A;  4N7T A;  5C66 A;  3T02 A;  5DLW A;  3UN2 A;  2GSN A;  1EQJ A;  1URB A;  4LR8 A;  2W5Q A;  4FDJ A;  3WBH A;  1E1Z P;  4CXU A;  1ALH A;  3TWZ A;  4KAY A;  5EGH A;  2RH6 A;  4NWJ A;  4LRA A;  3CMR A;  1ALJ A;  3Q3Q A;  1URA A;  5AJ9 A;  3TX0 A;  3IGZ B;  2IUC B;  1SHN A;  3NKQ A;  1KHL A;  4LRF A;  4MIV A;  1E3C P;  3T01 A;  5L0B A;  3UN3 A;  2W5S A;  4CYS A;  4LR2 A;  1AJB A;  4LQY A;  4KAV A;  1KH4 A;  4CYR A;  1K7H A;  4KJG A;  4ZG9 A;  4QAX A;  2GSO A;  2ZKT A;  3T00 A;  2QZU A;  3BDG B;  4LR9 A;  1HJK A;  1O99 A;  3NKM A;  1E33 P;  2G9Y A;  1B8J A;  3MK2 A;  3WAW A;  5KXA A;  5LRM A;  1EI6 A;  1KH9 A;  1AUK A;  2ANH A;  5L0K A;  4GTZ A;  4ZGA A;  4TN0 A;  4KJD A;  4CXK A;  1FSU A;  2GSU A;  1EW2 A;  2W5R A;  1ALI A;  4UPH A;  5K4P A;  3NVL A;  2VQR A;  1ZEF A;  3M8W A;  4B56 A;  4KM4 A;  1EJJ A;  3OT9 A;  1AJD A;  1KH7 A;  4GTW A;  5EGE A;  5IJQ A;  3SZZ A;  4MHX A;  3KD8 A;  2X98 A;  3B5Q A;  3M7V A;  1HDH A;  3IGY B;  4NWX A;  3WAV A;  1EW8 A;  1O98 A;  5HRT A;  3WAY A;  1ANI A;  4YR1 A;  2W5T A;  4MY4 A;  3UN5 A;  5TJ3 A;  1HQA A;  3BDH A;  3NKO A;  2D1G A;  1SHQ A; 
#chains in the Genus database with same CATH homology
 4ZG7 A;  3DPC A;  2GLQ A;  3M8Y A;  1KHK A;  2W5V A;  5GOV A;  3A52 A;  5INH A;  4UOP A;  3WAX A;  3SZY A;  2IUC A;  1KHN A;  3UO0 A;  3M8Z A;  4UPI A;  2W8S A;  3NKP A;  4LRD A;  1P49 A;  2IFY A;  3BDF A;  1Y6V A;  1ANJ A;  1ED8 A;  3NKR A;  3BDG A;  4LRE A;  1ZEB A;  4UPK A;  3MK1 A;  4UOR A;  1E2S P;  1EW9 A;  2W5W A;  5DLT A;  1ELY A;  5LRN A;  4UOO A;  1AJC A;  1KH5 A;  1KHJ A;  1ZED A;  3LXQ A;  5IJS A;  4GTY A;  3MK0 A;  3NKN A;  4CXS A;  3DYC A;  2W8D A;  3TG0 A;  4LRC A;  5GRR A;  2XRG A;  5L0E A;  4GTX A;  2W5X A;  5LQQ A;  4ZG6 A;  5DLV A;  4LR7 A;  3IDD A;  5LIA A;  1ELX A;  1ALK A;  2GA3 A;  1AJA A;  1N2L A;  3ED4 A;  4LRB A;  1ELZ A;  1N2K A;  3E2D A;  1ED9 A;  3UNY A;  4UPL A;  1Y7A A;  4FDI A;  2XR9 A;  4N7T A;  5C66 A;  3T02 A;  5DLW A;  3UN2 A;  2GSN A;  1EQJ A;  1URB A;  4LR8 A;  2W5Q A;  4FDJ A;  3WBH A;  1E1Z P;  4CXU A;  1ALH A;  3TWZ A;  4KAY A;  5EGH A;  2RH6 A;  4NWJ A;  4LRA A;  3CMR A;  1ALJ A;  3Q3Q A;  1URA A;  5AJ9 A;  3TX0 A;  3IGZ B;  2IUC B;  1SHN A;  3NKQ A;  1KHL A;  4LRF A;  4MIV A;  1E3C P;  3T01 A;  5L0B A;  3UN3 A;  2W5S A;  4CYS A;  4LR2 A;  1AJB A;  4LQY A;  4KAV A;  1KH4 A;  4CYR A;  1K7H A;  4KJG A;  4ZG9 A;  4QAX A;  2GSO A;  2ZKT A;  3T00 A;  2QZU A;  3BDG B;  4LR9 A;  1HJK A;  1O99 A;  3NKM A;  1E33 P;  2G9Y A;  1B8J A;  3MK2 A;  3WAW A;  5KXA A;  5LRM A;  1EI6 A;  1KH9 A;  1AUK A;  2ANH A;  5L0K A;  4GTZ A;  4ZGA A;  4TN0 A;  4KJD A;  4CXK A;  1FSU A;  2GSU A;  1EW2 A;  2W5R A;  1ALI A;  4UPH A;  5K4P A;  3NVL A;  2VQR A;  1ZEF A;  3M8W A;  4B56 A;  4KM4 A;  1EJJ A;  3OT9 A;  1AJD A;  1KH7 A;  4GTW A;  5EGE A;  5IJQ A;  3SZZ A;  4MHX A;  3KD8 A;  2X98 A;  3B5Q A;  3M7V A;  1HDH A;  3IGY B;  4NWX A;  3WAV A;  1EW8 A;  1O98 A;  5HRT A;  3WAY A;  1ANI A;  4YR1 A;  2W5T A;  4MY4 A;  3UN5 A;  5TJ3 A;  1HQA A;  3BDH A;  3NKO A;  2D1G A;  1SHQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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