1ALIA

Alkaline phosphatase mutant (h412n)
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQENTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Escherichia coli alkaline phosphatase: X-ray structural studies of a mutant enzyme (His-412-->Asn) at one of the catalytically important zinc binding sites.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolase (phosphoric monoester)
total genus 162
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1aliA00
3MK1A 4CXUA 1EQJA 4MHXA 1EI6A 4GTYA 4LRAA 3DPCA 4KM4A 1ZEBA 3MK0A 3T02A 5HRTA 2RH6A 1HJKA 2GSNA 3M7VA 4LRCA 3T01A 1E3CP 1EW2A 3UN2A 1P49A 1URAA 1ELXA 5DLWA 1O99A 3TWZA 2G9YA 1ALIA 1KH5A 4CYSA 4UORA 3UN5A 4TN0A 3NKRA 1N2KA 1E33P 4GTZA 1ANJA 4UOPA 5AJ9A 3WBHA 4CYRA 2X98A 4ZG9A 3E2DA 1KH9A 1KHJA 5GOVA 4FDJA 3WAXA 4NWXA 2GLQA 4LR7A 3MK2A 2XRGA 4LQYA 5LRMA 1ELZA 1HQAA 1ALKA 2ZKTA 1ELYA 3WAVA 1ED8A 3OT9A 4LRBA 3UN3A 4LR9A 4LR2A 3WAWA 5LRNA 5C66A 2ANHA 5IJSA 1KH7A 2VQRA 2IUCA 3T00A 3BDFA 1ZEDA 3LXQA 3DYCA 1B8JA 2W5QA 4ZGAA 3ED4A 2W5VA 1AJBA 1E1ZP 4KJGA 1ALJA 4MY4A 4MIVA 2GSOA 1Y6VA 3IGZB 2D1GA 3IDDA 5EGEA 2W5TA 4LR8A 1KHKA 5DLTA 1K7HA 3TX0A 5LQQA 1HDHA 1ALHA 1KHLA 2W5SA 1KHNA 1AUKA 3IGYB 3NKOA 1O98A 2W5WA 4LRFA 5KXAA 3KD8A 1E2SP 1FSUA 2GA3A 2W5XA 5EGHA 4UPLA 5L0EA 1SHNA 3NKPA 3SZYA 4KAYA 5DLVA 2GSUA 1URBA 3BDGA 4CXKA 5L0BA 2IFYA 4YR1A 2XR9A 1AJDA 3NKMA 1EW8A 1N2LA 3NVLA 4UPKA 2W8DA 4ZG7A 5L0KA 2QZUA 4UPIA 5GRRA 1ZEFA 3NKQA 3SZZA 5K4PA 4LRDA 1AJCA 4ZG6A 1ANIA 3M8YA 3M8WA 4KJDA 4QAXA 3M8ZA 5LIAA 4N7TA 3UNYA 4GTXA 4FDIA 3CMRA 1SHQA 4UPHA 5IJQA 1ED9A 3NKNA 2W5RA 1EJJA 4B56A 3WAYA 2W8SA 1EW9A 4KAVA 4NWJA 5TJ3A 4LREA 1AJAA 3UO0A 4UOOA 3A52A 5INHA 1Y7AA 4CXSA 3BDGB 3B5QA 1KH4A 3TG0A 3Q3QA 2IUCB 4GTWA 3BDHA
chains in the Genus database with same CATH superfamily
3MK1A 4CXUA 1EQJA 4MHXA 1EI6A 4GTYA 4LRAA 3DPCA 4KM4A 1ZEBA 3MK0A 3T02A 5HRTA 2RH6A 1HJKA 2GSNA 3M7VA 4LRCA 3T01A 1E3CP 1EW2A 3UN2A 1P49A 1URAA 1ELXA 5DLWA 1O99A 3TWZA 2G9YA 1ALIA 1KH5A 4CYSA 4UORA 3UN5A 4TN0A 3NKRA 1N2KA 1E33P 4GTZA 1ANJA 4UOPA 5AJ9A 3WBHA 4CYRA 2X98A 4ZG9A 3E2DA 1KH9A 1KHJA 5GOVA 4FDJA 3WAXA 4NWXA 2GLQA 4LR7A 3MK2A 2XRGA 4LQYA 5LRMA 1ELZA 1HQAA 1ALKA 2ZKTA 1ELYA 3WAVA 1ED8A 3OT9A 4LRBA 3UN3A 4LR9A 4LR2A 3WAWA 5LRNA 5C66A 2ANHA 5IJSA 1KH7A 2VQRA 2IUCA 3T00A 3BDFA 1ZEDA 3LXQA 3DYCA 1B8JA 2W5QA 4ZGAA 3ED4A 2W5VA 1AJBA 1E1ZP 4KJGA 1ALJA 4MY4A 4MIVA 2GSOA 1Y6VA 3IGZB 2D1GA 3IDDA 5EGEA 2W5TA 4LR8A 1KHKA 5DLTA 1K7HA 3TX0A 5LQQA 1HDHA 1ALHA 1KHLA 2W5SA 1KHNA 1AUKA 3IGYB 3NKOA 1O98A 2W5WA 4LRFA 5KXAA 3KD8A 1E2SP 1FSUA 2GA3A 2W5XA 5EGHA 4UPLA 5L0EA 1SHNA 3NKPA 3SZYA 4KAYA 5DLVA 2GSUA 1URBA 3BDGA 4CXKA 5L0BA 2IFYA 4YR1A 2XR9A 1AJDA 3NKMA 1EW8A 1N2LA 3NVLA 4UPKA 2W8DA 4ZG7A 5L0KA 2QZUA 4UPIA 5GRRA 1ZEFA 3NKQA 3SZZA 5K4PA 4LRDA 1AJCA 4ZG6A 1ANIA 3M8YA 3M8WA 4KJDA 4QAXA 3M8ZA 5LIAA 4N7TA 3UNYA 4GTXA 4FDIA 3CMRA 1SHQA 4UPHA 5IJQA 1ED9A 3NKNA 2W5RA 1EJJA 4B56A 3WAYA 2W8SA 1EW9A 4KAVA 4NWJA 5TJ3A 4LREA 1AJAA 3UO0A 4UOOA 3A52A 5INHA 1Y7AA 4CXSA 3BDGB 3B5QA 1KH4A 3TG0A 3Q3QA 2IUCB 4GTWA 3BDHA
chains in the Genus database with same CATH topology
3MK1A 4CXUA 1EQJA 4MHXA 1EI6A 4GTYA 4LRAA 3DPCA 4KM4A 1ZEBA 3MK0A 3T02A 5HRTA 2RH6A 1HJKA 2GSNA 3M7VA 4LRCA 3T01A 1E3CP 1EW2A 3UN2A 1P49A 1URAA 1ELXA 5DLWA 1O99A 3TWZA 2G9YA 1ALIA 1KH5A 4CYSA 4UORA 3UN5A 4TN0A 3NKRA 1N2KA 1E33P 4GTZA 1ANJA 4UOPA 5AJ9A 3WBHA 4CYRA 2X98A 4ZG9A 3E2DA 1KH9A 1KHJA 5GOVA 4FDJA 3WAXA 4NWXA 2GLQA 4LR7A 3MK2A 2XRGA 4LQYA 5LRMA 1ELZA 1HQAA 1ALKA 2ZKTA 1ELYA 3WAVA 1ED8A 3OT9A 4LRBA 3UN3A 4LR9A 4LR2A 3WAWA 5LRNA 5C66A 2ANHA 5IJSA 1KH7A 2VQRA 2IUCA 3T00A 3BDFA 1ZEDA 3LXQA 3DYCA 1B8JA 2W5QA 4ZGAA 3ED4A 2W5VA 1AJBA 1E1ZP 4KJGA 1ALJA 4MY4A 4MIVA 2GSOA 1Y6VA 3IGZB 2D1GA 3IDDA 5EGEA 2W5TA 4LR8A 1KHKA 5DLTA 1K7HA 3TX0A 5LQQA 1HDHA 1ALHA 1KHLA 2W5SA 1KHNA 1AUKA 3IGYB 3NKOA 1O98A 2W5WA 4LRFA 5KXAA 3KD8A 1E2SP 1FSUA 2GA3A 2W5XA 5EGHA 4UPLA 5L0EA 1SHNA 3NKPA 3SZYA 4KAYA 5DLVA 2GSUA 1URBA 3BDGA 4CXKA 5L0BA 2IFYA 4YR1A 2XR9A 1AJDA 3NKMA 1EW8A 1N2LA 3NVLA 4UPKA 2W8DA 4ZG7A 5L0KA 2QZUA 4UPIA 5GRRA 1ZEFA 3NKQA 3SZZA 5K4PA 4LRDA 1AJCA 4ZG6A 1ANIA 3M8YA 3M8WA 4KJDA 4QAXA 3M8ZA 5LIAA 4N7TA 3UNYA 4GTXA 4FDIA 3CMRA 1SHQA 4UPHA 5IJQA 1ED9A 3NKNA 2W5RA 1EJJA 4B56A 3WAYA 2W8SA 1EW9A 4KAVA 4NWJA 5TJ3A 4LREA 1AJAA 3UO0A 4UOOA 3A52A 5INHA 1Y7AA 4CXSA 3BDGB 3B5QA 1KH4A 3TG0A 3Q3QA 2IUCB 4GTWA 3BDHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MK1 A;  4CXU A;  1EQJ A;  4MHX A;  1EI6 A;  4GTY A;  4LRA A;  3DPC A;  4KM4 A;  1ZEB A;  3MK0 A;  3T02 A;  5HRT A;  2RH6 A;  1HJK A;  2GSN A;  3M7V A;  4LRC A;  3T01 A;  1E3C P;  1EW2 A;  3UN2 A;  1P49 A;  1URA A;  1ELX A;  5DLW A;  1O99 A;  3TWZ A;  2G9Y A;  1ALI A;  1KH5 A;  4CYS A;  4UOR A;  3UN5 A;  4TN0 A;  3NKR A;  1N2K A;  1E33 P;  4GTZ A;  1ANJ A;  4UOP A;  5AJ9 A;  3WBH A;  4CYR A;  2X98 A;  4ZG9 A;  3E2D A;  1KH9 A;  1KHJ A;  5GOV A;  4FDJ A;  3WAX A;  4NWX A;  2GLQ A;  4LR7 A;  3MK2 A;  2XRG A;  4LQY A;  5LRM A;  1ELZ A;  1HQA A;  1ALK A;  2ZKT A;  1ELY A;  3WAV A;  1ED8 A;  3OT9 A;  4LRB A;  3UN3 A;  4LR9 A;  4LR2 A;  3WAW A;  5LRN A;  5C66 A;  2ANH A;  5IJS A;  1KH7 A;  2VQR A;  2IUC A;  3T00 A;  3BDF A;  1ZED A;  3LXQ A;  3DYC A;  1B8J A;  2W5Q A;  4ZGA A;  3ED4 A;  2W5V A;  1AJB A;  1E1Z P;  4KJG A;  1ALJ A;  4MY4 A;  4MIV A;  2GSO A;  1Y6V A;  3IGZ B;  2D1G A;  3IDD A;  5EGE A;  2W5T A;  4LR8 A;  1KHK A;  5DLT A;  1K7H A;  3TX0 A;  5LQQ A;  1HDH A;  1ALH A;  1KHL A;  2W5S A;  1KHN A;  1AUK A;  3IGY B;  3NKO A;  1O98 A;  2W5W A;  4LRF A;  5KXA A;  3KD8 A;  1E2S P;  1FSU A;  2GA3 A;  2W5X A;  5EGH A;  4UPL A;  5L0E A;  1SHN A;  3NKP A;  3SZY A;  4KAY A;  5DLV A;  2GSU A;  1URB A;  3BDG A;  4CXK A;  5L0B A;  2IFY A;  4YR1 A;  2XR9 A;  1AJD A;  3NKM A;  1EW8 A;  1N2L A;  3NVL A;  4UPK A;  2W8D A;  4ZG7 A;  5L0K A;  2QZU A;  4UPI A;  5GRR A;  1ZEF A;  3NKQ A;  3SZZ A;  5K4P A;  4LRD A;  1AJC A;  4ZG6 A;  1ANI A;  3M8Y A;  3M8W A;  4KJD A;  4QAX A;  3M8Z A;  5LIA A;  4N7T A;  3UNY A;  4GTX A;  4FDI A;  3CMR A;  1SHQ A;  4UPH A;  5IJQ A;  1ED9 A;  3NKN A;  2W5R A;  1EJJ A;  4B56 A;  3WAY A;  2W8S A;  1EW9 A;  4KAV A;  4NWJ A;  5TJ3 A;  4LRE A;  1AJA A;  3UO0 A;  4UOO A;  3A52 A;  5INH A;  1Y7A A;  4CXS A;  3BDG B;  3B5Q A;  1KH4 A;  3TG0 A;  3Q3Q A;  2IUC B;  4GTW A;  3BDH A; 
#chains in the Genus database with same CATH topology
 3MK1 A;  4CXU A;  1EQJ A;  4MHX A;  1EI6 A;  4GTY A;  4LRA A;  3DPC A;  4KM4 A;  1ZEB A;  3MK0 A;  3T02 A;  5HRT A;  2RH6 A;  1HJK A;  2GSN A;  3M7V A;  4LRC A;  3T01 A;  1E3C P;  1EW2 A;  3UN2 A;  1P49 A;  1URA A;  1ELX A;  5DLW A;  1O99 A;  3TWZ A;  2G9Y A;  1ALI A;  1KH5 A;  4CYS A;  4UOR A;  3UN5 A;  4TN0 A;  3NKR A;  1N2K A;  1E33 P;  4GTZ A;  1ANJ A;  4UOP A;  5AJ9 A;  3WBH A;  4CYR A;  2X98 A;  4ZG9 A;  3E2D A;  1KH9 A;  1KHJ A;  5GOV A;  4FDJ A;  3WAX A;  4NWX A;  2GLQ A;  4LR7 A;  3MK2 A;  2XRG A;  4LQY A;  5LRM A;  1ELZ A;  1HQA A;  1ALK A;  2ZKT A;  1ELY A;  3WAV A;  1ED8 A;  3OT9 A;  4LRB A;  3UN3 A;  4LR9 A;  4LR2 A;  3WAW A;  5LRN A;  5C66 A;  2ANH A;  5IJS A;  1KH7 A;  2VQR A;  2IUC A;  3T00 A;  3BDF A;  1ZED A;  3LXQ A;  3DYC A;  1B8J A;  2W5Q A;  4ZGA A;  3ED4 A;  2W5V A;  1AJB A;  1E1Z P;  4KJG A;  1ALJ A;  4MY4 A;  4MIV A;  2GSO A;  1Y6V A;  3IGZ B;  2D1G A;  3IDD A;  5EGE A;  2W5T A;  4LR8 A;  1KHK A;  5DLT A;  1K7H A;  3TX0 A;  5LQQ A;  1HDH A;  1ALH A;  1KHL A;  2W5S A;  1KHN A;  1AUK A;  3IGY B;  3NKO A;  1O98 A;  2W5W A;  4LRF A;  5KXA A;  3KD8 A;  1E2S P;  1FSU A;  2GA3 A;  2W5X A;  5EGH A;  4UPL A;  5L0E A;  1SHN A;  3NKP A;  3SZY A;  4KAY A;  5DLV A;  2GSU A;  1URB A;  3BDG A;  4CXK A;  5L0B A;  2IFY A;  4YR1 A;  2XR9 A;  1AJD A;  3NKM A;  1EW8 A;  1N2L A;  3NVL A;  4UPK A;  2W8D A;  4ZG7 A;  5L0K A;  2QZU A;  4UPI A;  5GRR A;  1ZEF A;  3NKQ A;  3SZZ A;  5K4P A;  4LRD A;  1AJC A;  4ZG6 A;  1ANI A;  3M8Y A;  3M8W A;  4KJD A;  4QAX A;  3M8Z A;  5LIA A;  4N7T A;  3UNY A;  4GTX A;  4FDI A;  3CMR A;  1SHQ A;  4UPH A;  5IJQ A;  1ED9 A;  3NKN A;  2W5R A;  1EJJ A;  4B56 A;  3WAY A;  2W8S A;  1EW9 A;  4KAV A;  4NWJ A;  5TJ3 A;  4LRE A;  1AJA A;  3UO0 A;  4UOO A;  3A52 A;  5INH A;  1Y7A A;  4CXS A;  3BDG B;  3B5Q A;  1KH4 A;  3TG0 A;  3Q3Q A;  2IUC B;  4GTW A;  3BDH A; 
#chains in the Genus database with same CATH homology
 3MK1 A;  4CXU A;  1EQJ A;  4MHX A;  1EI6 A;  4GTY A;  4LRA A;  3DPC A;  4KM4 A;  1ZEB A;  3MK0 A;  3T02 A;  5HRT A;  2RH6 A;  1HJK A;  2GSN A;  3M7V A;  4LRC A;  3T01 A;  1E3C P;  1EW2 A;  3UN2 A;  1P49 A;  1URA A;  1ELX A;  5DLW A;  1O99 A;  3TWZ A;  2G9Y A;  1ALI A;  1KH5 A;  4CYS A;  4UOR A;  3UN5 A;  4TN0 A;  3NKR A;  1N2K A;  1E33 P;  4GTZ A;  1ANJ A;  4UOP A;  5AJ9 A;  3WBH A;  4CYR A;  2X98 A;  4ZG9 A;  3E2D A;  1KH9 A;  1KHJ A;  5GOV A;  4FDJ A;  3WAX A;  4NWX A;  2GLQ A;  4LR7 A;  3MK2 A;  2XRG A;  4LQY A;  5LRM A;  1ELZ A;  1HQA A;  1ALK A;  2ZKT A;  1ELY A;  3WAV A;  1ED8 A;  3OT9 A;  4LRB A;  3UN3 A;  4LR9 A;  4LR2 A;  3WAW A;  5LRN A;  5C66 A;  2ANH A;  5IJS A;  1KH7 A;  2VQR A;  2IUC A;  3T00 A;  3BDF A;  1ZED A;  3LXQ A;  3DYC A;  1B8J A;  2W5Q A;  4ZGA A;  3ED4 A;  2W5V A;  1AJB A;  1E1Z P;  4KJG A;  1ALJ A;  4MY4 A;  4MIV A;  2GSO A;  1Y6V A;  3IGZ B;  2D1G A;  3IDD A;  5EGE A;  2W5T A;  4LR8 A;  1KHK A;  5DLT A;  1K7H A;  3TX0 A;  5LQQ A;  1HDH A;  1ALH A;  1KHL A;  2W5S A;  1KHN A;  1AUK A;  3IGY B;  3NKO A;  1O98 A;  2W5W A;  4LRF A;  5KXA A;  3KD8 A;  1E2S P;  1FSU A;  2GA3 A;  2W5X A;  5EGH A;  4UPL A;  5L0E A;  1SHN A;  3NKP A;  3SZY A;  4KAY A;  5DLV A;  2GSU A;  1URB A;  3BDG A;  4CXK A;  5L0B A;  2IFY A;  4YR1 A;  2XR9 A;  1AJD A;  3NKM A;  1EW8 A;  1N2L A;  3NVL A;  4UPK A;  2W8D A;  4ZG7 A;  5L0K A;  2QZU A;  4UPI A;  5GRR A;  1ZEF A;  3NKQ A;  3SZZ A;  5K4P A;  4LRD A;  1AJC A;  4ZG6 A;  1ANI A;  3M8Y A;  3M8W A;  4KJD A;  4QAX A;  3M8Z A;  5LIA A;  4N7T A;  3UNY A;  4GTX A;  4FDI A;  3CMR A;  1SHQ A;  4UPH A;  5IJQ A;  1ED9 A;  3NKN A;  2W5R A;  1EJJ A;  4B56 A;  3WAY A;  2W8S A;  1EW9 A;  4KAV A;  4NWJ A;  5TJ3 A;  4LRE A;  1AJA A;  3UO0 A;  4UOO A;  3A52 A;  5INH A;  1Y7A A;  4CXS A;  3BDG B;  3B5Q A;  1KH4 A;  3TG0 A;  3Q3Q A;  2IUC B;  4GTW A;  3BDH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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