1ANIA

Alkaline phosphatase (d153h, k328h)
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
446
structure length
446
Chain Sequence
b'MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDHQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
total genus 161
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-09-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1aniA00
3A52A 3T01A 3CMRA 4LRDA 2GLQA 2D1GA 3BDGB 4UORA 4UPIA 4CYRA 1URAA 5INHA 1ED9A 3NKPA 2GSOA 2W5VA 3WAVA 3IDDA 1HJKA 1ELZA 1K7HA 1KH5A 5HRTA 1B8JA 1N2KA 2VQRA 5DLVA 1E33P 3T02A 4ZG7A 5IJQA 3NKQA 2W5TA 2IUCA 2W5RA 1Y6VA 4YR1A 3M7VA 5L0BA 2XRGA 1EI6A 1EW2A 5LIAA 3B5QA 4GTZA 4QAXA 1SHQA 2XR9A 1HQAA 2W5WA 1EW9A 3M8ZA 2W8SA 3WBHA 3WAYA 3NKRA 4GTXA 4LR9A 1KHKA 4CXUA 1KH7A 2GA3A 4KJDA 3DYCA 1ANJA 3NKNA 1ZEFA 3Q3QA 1KH9A 4LR7A 1ANIA 4CYSA 1AJCA 4LR8A 1KHNA 3KD8A 3SZYA 4UPHA 4KJGA 3MK2A 3T00A 4FDJA 4LR2A 4CXSA 1AJBA 1ZEDA 4B56A 2G9YA 5GOVA 1ELXA 1O99A 3DPCA 3M8WA 3NKOA 4N7TA 2GSNA 3UN3A 4UOOA 5LQQA 3BDHA 4ZG6A 3TX0A 3E2DA 1SHNA 4TN0A 3LXQA 4UPKA 1URBA 1KH4A 5IJSA 1AUKA 3IGYB 2QZUA 3MK0A 4LQYA 1P49A 3SZZA 2W5SA 5AJ9A 1Y7AA 3UN5A 2ANHA 5L0EA 4KM4A 1EJJA 2IUCB 1ZEBA 5LRNA 4LRFA 4ZGAA 5DLWA 3M8YA 3UNYA 3MK1A 5DLTA 3WAXA 1E2SP 4CXKA 4ZG9A 1ALJA 4UOPA 4NWJA 1ALKA 4MHXA 1KHLA 5EGHA 1ALHA 5K4PA 1EW8A 4GTWA 1E3CP 4FDIA 3ED4A 3TWZA 5TJ3A 3UO0A 1HDHA 5LRMA 3IGZB 3OT9A 5KXAA 3BDGA 3UN2A 3BDFA 1O98A 1ELYA 4UPLA 4LRCA 3NKMA 4GTYA 4NWXA 2W8DA 5L0KA 2GSUA 3TG0A 2W5QA 3WAWA 4LRAA 5GRRA 1E1ZP 4LRBA 4LREA 3NVLA 2X98A 2IFYA 1AJDA 4MY4A 5C66A 1FSUA 1KHJA 1AJAA 1ED8A 1EQJA 4KAVA 4MIVA 2RH6A 2W5XA 4KAYA 2ZKTA 5EGEA 1N2LA 1ALIA
chains in the Genus database with same CATH superfamily
3A52A 3T01A 3CMRA 4LRDA 2GLQA 2D1GA 3BDGB 4UORA 4UPIA 4CYRA 1URAA 5INHA 1ED9A 3NKPA 2GSOA 2W5VA 3WAVA 3IDDA 1HJKA 1ELZA 1K7HA 1KH5A 5HRTA 1B8JA 1N2KA 2VQRA 5DLVA 1E33P 3T02A 4ZG7A 5IJQA 3NKQA 2W5TA 2IUCA 2W5RA 1Y6VA 4YR1A 3M7VA 5L0BA 2XRGA 1EI6A 1EW2A 5LIAA 3B5QA 4GTZA 4QAXA 1SHQA 2XR9A 1HQAA 2W5WA 1EW9A 3M8ZA 2W8SA 3WBHA 3WAYA 3NKRA 4GTXA 4LR9A 1KHKA 4CXUA 1KH7A 2GA3A 4KJDA 3DYCA 1ANJA 3NKNA 1ZEFA 3Q3QA 1KH9A 4LR7A 1ANIA 4CYSA 1AJCA 4LR8A 1KHNA 3KD8A 3SZYA 4UPHA 4KJGA 3MK2A 3T00A 4FDJA 4LR2A 4CXSA 1AJBA 1ZEDA 4B56A 2G9YA 5GOVA 1ELXA 1O99A 3DPCA 3M8WA 3NKOA 4N7TA 2GSNA 3UN3A 4UOOA 5LQQA 3BDHA 4ZG6A 3TX0A 3E2DA 1SHNA 4TN0A 3LXQA 4UPKA 1URBA 1KH4A 5IJSA 1AUKA 3IGYB 2QZUA 3MK0A 4LQYA 1P49A 3SZZA 2W5SA 5AJ9A 1Y7AA 3UN5A 2ANHA 5L0EA 4KM4A 1EJJA 2IUCB 1ZEBA 5LRNA 4LRFA 4ZGAA 5DLWA 3M8YA 3UNYA 3MK1A 5DLTA 3WAXA 1E2SP 4CXKA 4ZG9A 1ALJA 4UOPA 4NWJA 1ALKA 4MHXA 1KHLA 5EGHA 1ALHA 5K4PA 1EW8A 4GTWA 1E3CP 4FDIA 3ED4A 3TWZA 5TJ3A 3UO0A 1HDHA 5LRMA 3IGZB 3OT9A 5KXAA 3BDGA 3UN2A 3BDFA 1O98A 1ELYA 4UPLA 4LRCA 3NKMA 4GTYA 4NWXA 2W8DA 5L0KA 2GSUA 3TG0A 2W5QA 3WAWA 4LRAA 5GRRA 1E1ZP 4LRBA 4LREA 3NVLA 2X98A 2IFYA 1AJDA 4MY4A 5C66A 1FSUA 1KHJA 1AJAA 1ED8A 1EQJA 4KAVA 4MIVA 2RH6A 2W5XA 4KAYA 2ZKTA 5EGEA 1N2LA 1ALIA
chains in the Genus database with same CATH topology
3A52A 3T01A 3CMRA 4LRDA 2GLQA 2D1GA 3BDGB 4UORA 4UPIA 4CYRA 1URAA 5INHA 1ED9A 3NKPA 2GSOA 2W5VA 3WAVA 3IDDA 1HJKA 1ELZA 1K7HA 1KH5A 5HRTA 1B8JA 1N2KA 2VQRA 5DLVA 1E33P 3T02A 4ZG7A 5IJQA 3NKQA 2W5TA 2IUCA 2W5RA 1Y6VA 4YR1A 3M7VA 5L0BA 2XRGA 1EI6A 1EW2A 5LIAA 3B5QA 4GTZA 4QAXA 1SHQA 2XR9A 1HQAA 2W5WA 1EW9A 3M8ZA 2W8SA 3WBHA 3WAYA 3NKRA 4GTXA 4LR9A 1KHKA 4CXUA 1KH7A 2GA3A 4KJDA 3DYCA 1ANJA 3NKNA 1ZEFA 3Q3QA 1KH9A 4LR7A 1ANIA 4CYSA 1AJCA 4LR8A 1KHNA 3KD8A 3SZYA 4UPHA 4KJGA 3MK2A 3T00A 4FDJA 4LR2A 4CXSA 1AJBA 1ZEDA 4B56A 2G9YA 5GOVA 1ELXA 1O99A 3DPCA 3M8WA 3NKOA 4N7TA 2GSNA 3UN3A 4UOOA 5LQQA 3BDHA 4ZG6A 3TX0A 3E2DA 1SHNA 4TN0A 3LXQA 4UPKA 1URBA 1KH4A 5IJSA 1AUKA 3IGYB 2QZUA 3MK0A 4LQYA 1P49A 3SZZA 2W5SA 5AJ9A 1Y7AA 3UN5A 2ANHA 5L0EA 4KM4A 1EJJA 2IUCB 1ZEBA 5LRNA 4LRFA 4ZGAA 5DLWA 3M8YA 3UNYA 3MK1A 5DLTA 3WAXA 1E2SP 4CXKA 4ZG9A 1ALJA 4UOPA 4NWJA 1ALKA 4MHXA 1KHLA 5EGHA 1ALHA 5K4PA 1EW8A 4GTWA 1E3CP 4FDIA 3ED4A 3TWZA 5TJ3A 3UO0A 1HDHA 5LRMA 3IGZB 3OT9A 5KXAA 3BDGA 3UN2A 3BDFA 1O98A 1ELYA 4UPLA 4LRCA 3NKMA 4GTYA 4NWXA 2W8DA 5L0KA 2GSUA 3TG0A 2W5QA 3WAWA 4LRAA 5GRRA 1E1ZP 4LRBA 4LREA 3NVLA 2X98A 2IFYA 1AJDA 4MY4A 5C66A 1FSUA 1KHJA 1AJAA 1ED8A 1EQJA 4KAVA 4MIVA 2RH6A 2W5XA 4KAYA 2ZKTA 5EGEA 1N2LA 1ALIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3A52 A;  3T01 A;  3CMR A;  4LRD A;  2GLQ A;  2D1G A;  3BDG B;  4UOR A;  4UPI A;  4CYR A;  1URA A;  5INH A;  1ED9 A;  3NKP A;  2GSO A;  2W5V A;  3WAV A;  3IDD A;  1HJK A;  1ELZ A;  1K7H A;  1KH5 A;  5HRT A;  1B8J A;  1N2K A;  2VQR A;  5DLV A;  1E33 P;  3T02 A;  4ZG7 A;  5IJQ A;  3NKQ A;  2W5T A;  2IUC A;  2W5R A;  1Y6V A;  4YR1 A;  3M7V A;  5L0B A;  2XRG A;  1EI6 A;  1EW2 A;  5LIA A;  3B5Q A;  4GTZ A;  4QAX A;  1SHQ A;  2XR9 A;  1HQA A;  2W5W A;  1EW9 A;  3M8Z A;  2W8S A;  3WBH A;  3WAY A;  3NKR A;  4GTX A;  4LR9 A;  1KHK A;  4CXU A;  1KH7 A;  2GA3 A;  4KJD A;  3DYC A;  1ANJ A;  3NKN A;  1ZEF A;  3Q3Q A;  1KH9 A;  4LR7 A;  1ANI A;  4CYS A;  1AJC A;  4LR8 A;  1KHN A;  3KD8 A;  3SZY A;  4UPH A;  4KJG A;  3MK2 A;  3T00 A;  4FDJ A;  4LR2 A;  4CXS A;  1AJB A;  1ZED A;  4B56 A;  2G9Y A;  5GOV A;  1ELX A;  1O99 A;  3DPC A;  3M8W A;  3NKO A;  4N7T A;  2GSN A;  3UN3 A;  4UOO A;  5LQQ A;  3BDH A;  4ZG6 A;  3TX0 A;  3E2D A;  1SHN A;  4TN0 A;  3LXQ A;  4UPK A;  1URB A;  1KH4 A;  5IJS A;  1AUK A;  3IGY B;  2QZU A;  3MK0 A;  4LQY A;  1P49 A;  3SZZ A;  2W5S A;  5AJ9 A;  1Y7A A;  3UN5 A;  2ANH A;  5L0E A;  4KM4 A;  1EJJ A;  2IUC B;  1ZEB A;  5LRN A;  4LRF A;  4ZGA A;  5DLW A;  3M8Y A;  3UNY A;  3MK1 A;  5DLT A;  3WAX A;  1E2S P;  4CXK A;  4ZG9 A;  1ALJ A;  4UOP A;  4NWJ A;  1ALK A;  4MHX A;  1KHL A;  5EGH A;  1ALH A;  5K4P A;  1EW8 A;  4GTW A;  1E3C P;  4FDI A;  3ED4 A;  3TWZ A;  5TJ3 A;  3UO0 A;  1HDH A;  5LRM A;  3IGZ B;  3OT9 A;  5KXA A;  3BDG A;  3UN2 A;  3BDF A;  1O98 A;  1ELY A;  4UPL A;  4LRC A;  3NKM A;  4GTY A;  4NWX A;  2W8D A;  5L0K A;  2GSU A;  3TG0 A;  2W5Q A;  3WAW A;  4LRA A;  5GRR A;  1E1Z P;  4LRB A;  4LRE A;  3NVL A;  2X98 A;  2IFY A;  1AJD A;  4MY4 A;  5C66 A;  1FSU A;  1KHJ A;  1AJA A;  1ED8 A;  1EQJ A;  4KAV A;  4MIV A;  2RH6 A;  2W5X A;  4KAY A;  2ZKT A;  5EGE A;  1N2L A;  1ALI A; 
#chains in the Genus database with same CATH topology
 3A52 A;  3T01 A;  3CMR A;  4LRD A;  2GLQ A;  2D1G A;  3BDG B;  4UOR A;  4UPI A;  4CYR A;  1URA A;  5INH A;  1ED9 A;  3NKP A;  2GSO A;  2W5V A;  3WAV A;  3IDD A;  1HJK A;  1ELZ A;  1K7H A;  1KH5 A;  5HRT A;  1B8J A;  1N2K A;  2VQR A;  5DLV A;  1E33 P;  3T02 A;  4ZG7 A;  5IJQ A;  3NKQ A;  2W5T A;  2IUC A;  2W5R A;  1Y6V A;  4YR1 A;  3M7V A;  5L0B A;  2XRG A;  1EI6 A;  1EW2 A;  5LIA A;  3B5Q A;  4GTZ A;  4QAX A;  1SHQ A;  2XR9 A;  1HQA A;  2W5W A;  1EW9 A;  3M8Z A;  2W8S A;  3WBH A;  3WAY A;  3NKR A;  4GTX A;  4LR9 A;  1KHK A;  4CXU A;  1KH7 A;  2GA3 A;  4KJD A;  3DYC A;  1ANJ A;  3NKN A;  1ZEF A;  3Q3Q A;  1KH9 A;  4LR7 A;  1ANI A;  4CYS A;  1AJC A;  4LR8 A;  1KHN A;  3KD8 A;  3SZY A;  4UPH A;  4KJG A;  3MK2 A;  3T00 A;  4FDJ A;  4LR2 A;  4CXS A;  1AJB A;  1ZED A;  4B56 A;  2G9Y A;  5GOV A;  1ELX A;  1O99 A;  3DPC A;  3M8W A;  3NKO A;  4N7T A;  2GSN A;  3UN3 A;  4UOO A;  5LQQ A;  3BDH A;  4ZG6 A;  3TX0 A;  3E2D A;  1SHN A;  4TN0 A;  3LXQ A;  4UPK A;  1URB A;  1KH4 A;  5IJS A;  1AUK A;  3IGY B;  2QZU A;  3MK0 A;  4LQY A;  1P49 A;  3SZZ A;  2W5S A;  5AJ9 A;  1Y7A A;  3UN5 A;  2ANH A;  5L0E A;  4KM4 A;  1EJJ A;  2IUC B;  1ZEB A;  5LRN A;  4LRF A;  4ZGA A;  5DLW A;  3M8Y A;  3UNY A;  3MK1 A;  5DLT A;  3WAX A;  1E2S P;  4CXK A;  4ZG9 A;  1ALJ A;  4UOP A;  4NWJ A;  1ALK A;  4MHX A;  1KHL A;  5EGH A;  1ALH A;  5K4P A;  1EW8 A;  4GTW A;  1E3C P;  4FDI A;  3ED4 A;  3TWZ A;  5TJ3 A;  3UO0 A;  1HDH A;  5LRM A;  3IGZ B;  3OT9 A;  5KXA A;  3BDG A;  3UN2 A;  3BDF A;  1O98 A;  1ELY A;  4UPL A;  4LRC A;  3NKM A;  4GTY A;  4NWX A;  2W8D A;  5L0K A;  2GSU A;  3TG0 A;  2W5Q A;  3WAW A;  4LRA A;  5GRR A;  1E1Z P;  4LRB A;  4LRE A;  3NVL A;  2X98 A;  2IFY A;  1AJD A;  4MY4 A;  5C66 A;  1FSU A;  1KHJ A;  1AJA A;  1ED8 A;  1EQJ A;  4KAV A;  4MIV A;  2RH6 A;  2W5X A;  4KAY A;  2ZKT A;  5EGE A;  1N2L A;  1ALI A; 
#chains in the Genus database with same CATH homology
 3A52 A;  3T01 A;  3CMR A;  4LRD A;  2GLQ A;  2D1G A;  3BDG B;  4UOR A;  4UPI A;  4CYR A;  1URA A;  5INH A;  1ED9 A;  3NKP A;  2GSO A;  2W5V A;  3WAV A;  3IDD A;  1HJK A;  1ELZ A;  1K7H A;  1KH5 A;  5HRT A;  1B8J A;  1N2K A;  2VQR A;  5DLV A;  1E33 P;  3T02 A;  4ZG7 A;  5IJQ A;  3NKQ A;  2W5T A;  2IUC A;  2W5R A;  1Y6V A;  4YR1 A;  3M7V A;  5L0B A;  2XRG A;  1EI6 A;  1EW2 A;  5LIA A;  3B5Q A;  4GTZ A;  4QAX A;  1SHQ A;  2XR9 A;  1HQA A;  2W5W A;  1EW9 A;  3M8Z A;  2W8S A;  3WBH A;  3WAY A;  3NKR A;  4GTX A;  4LR9 A;  1KHK A;  4CXU A;  1KH7 A;  2GA3 A;  4KJD A;  3DYC A;  1ANJ A;  3NKN A;  1ZEF A;  3Q3Q A;  1KH9 A;  4LR7 A;  1ANI A;  4CYS A;  1AJC A;  4LR8 A;  1KHN A;  3KD8 A;  3SZY A;  4UPH A;  4KJG A;  3MK2 A;  3T00 A;  4FDJ A;  4LR2 A;  4CXS A;  1AJB A;  1ZED A;  4B56 A;  2G9Y A;  5GOV A;  1ELX A;  1O99 A;  3DPC A;  3M8W A;  3NKO A;  4N7T A;  2GSN A;  3UN3 A;  4UOO A;  5LQQ A;  3BDH A;  4ZG6 A;  3TX0 A;  3E2D A;  1SHN A;  4TN0 A;  3LXQ A;  4UPK A;  1URB A;  1KH4 A;  5IJS A;  1AUK A;  3IGY B;  2QZU A;  3MK0 A;  4LQY A;  1P49 A;  3SZZ A;  2W5S A;  5AJ9 A;  1Y7A A;  3UN5 A;  2ANH A;  5L0E A;  4KM4 A;  1EJJ A;  2IUC B;  1ZEB A;  5LRN A;  4LRF A;  4ZGA A;  5DLW A;  3M8Y A;  3UNY A;  3MK1 A;  5DLT A;  3WAX A;  1E2S P;  4CXK A;  4ZG9 A;  1ALJ A;  4UOP A;  4NWJ A;  1ALK A;  4MHX A;  1KHL A;  5EGH A;  1ALH A;  5K4P A;  1EW8 A;  4GTW A;  1E3C P;  4FDI A;  3ED4 A;  3TWZ A;  5TJ3 A;  3UO0 A;  1HDH A;  5LRM A;  3IGZ B;  3OT9 A;  5KXA A;  3BDG A;  3UN2 A;  3BDF A;  1O98 A;  1ELY A;  4UPL A;  4LRC A;  3NKM A;  4GTY A;  4NWX A;  2W8D A;  5L0K A;  2GSU A;  3TG0 A;  2W5Q A;  3WAW A;  4LRA A;  5GRR A;  1E1Z P;  4LRB A;  4LRE A;  3NVL A;  2X98 A;  2IFY A;  1AJD A;  4MY4 A;  5C66 A;  1FSU A;  1KHJ A;  1AJA A;  1ED8 A;  1EQJ A;  4KAV A;  4MIV A;  2RH6 A;  2W5X A;  4KAY A;  2ZKT A;  5EGE A;  1N2L A;  1ALI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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