1ANIA

Alkaline phosphatase (d153h, k328h)
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDHQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
total genus 161
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-09-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1aniA00
2ANHA 5KXAA 4LRCA 1AJDA 1EQJA 1N2LA 1ALIA 1AJAA 1O98A 3NKOA 5LIAA 1ELXA 1KH4A 4UPLA 4LRBA 4TN0A 2X98A 3MK1A 4KJDA 4QAXA 3UN5A 1ED8A 3NKRA 4CXKA 3LXQA 1KH7A 4KM4A 1EJJA 1KH9A 2XR9A 1FSUA 1O99A 4UPIA 4LRFA 1ELZA 4GTXA 4LR9A 4UPHA 3WAYA 3TWZA 3BDHA 2GSOA 3TX0A 2W8SA 5GOVA 5DLTA 4FDJA 1HJKA 1ALHA 4MHXA 1SHNA 1HQAA 5AJ9A 1ZEBA 3DPCA 4CYSA 3UO0A 3M8YA 3T02A 2XRGA 4LR8A 2IUCB 3ED4A 2W5WA 4ZG7A 2W8DA 5IJSA 4LRDA 5L0KA 2RH6A 1SHQA 5L0EA 1ANJA 1ANIA 5INHA 3T00A 5K4PA 4KAYA 5EGEA 3IGYB 4KAVA 3MK0A 3M8WA 3NKNA 3OT9A 3UN3A 1AUKA 1AJBA 4UORA 1Y7AA 5EGHA 4MY4A 3WAVA 5IJQA 5GRRA 4CXSA 4LRAA 1E1ZP 4GTZA 1HDHA 1EW8A 3SZYA 3WAXA 5L0BA 1ALJA 4ZGAA 1B8JA 3BDGA 1ED9A 1AJCA 3E2DA 4NWXA 4UPKA 4FDIA 3WBHA 3BDFA 1E3CP 3M8ZA 2ZKTA 4GTWA 4UOOA 2W5SA 1E33P 3CMRA 3DYCA 5LQQA 2VQRA 4LQYA 3IGZB 3A52A 4CYRA 3WAWA 2GLQA 5TJ3A 4LR7A 3UN2A 2W5RA 3NKQA 1KHLA 3Q3QA 3TG0A 1ZEFA 1Y6VA 2QZUA 4N7TA 2GSUA 4UOPA 3M7VA 4ZG9A 1EW2A 2W5XA 2W5QA 1E2SP 2D1GA 4CXUA 1URBA 3KD8A 5LRNA 5HRTA 3MK2A 1EW9A 4LR2A 5DLVA 3NVLA 4KJGA 1EI6A 2W5TA 5LRMA 1K7HA 3B5QA 4B56A 2IUCA 2IFYA 3NKMA 2GA3A 4NWJA 3T01A 4ZG6A 1ALKA 2G9YA 2W5VA 4LREA 1KHJA 5DLWA 1URAA 1KHNA 3BDGB 5C66A 1ELYA 3IDDA 1KHKA 3NKPA 4GTYA 3UNYA 1P49A 1N2KA 1KH5A 4MIVA 4YR1A 1ZEDA 2GSNA 3SZZA
chains in the Genus database with same CATH superfamily
2ANHA 5KXAA 4LRCA 1AJDA 1EQJA 1N2LA 1ALIA 1AJAA 1O98A 3NKOA 5LIAA 1ELXA 1KH4A 4UPLA 4LRBA 4TN0A 2X98A 3MK1A 4KJDA 4QAXA 3UN5A 1ED8A 3NKRA 4CXKA 3LXQA 1KH7A 4KM4A 1EJJA 1KH9A 2XR9A 1FSUA 1O99A 4UPIA 4LRFA 1ELZA 4GTXA 4LR9A 4UPHA 3WAYA 3TWZA 3BDHA 2GSOA 3TX0A 2W8SA 5GOVA 5DLTA 4FDJA 1HJKA 1ALHA 4MHXA 1SHNA 1HQAA 5AJ9A 1ZEBA 3DPCA 4CYSA 3UO0A 3M8YA 3T02A 2XRGA 4LR8A 2IUCB 3ED4A 2W5WA 4ZG7A 2W8DA 5IJSA 4LRDA 5L0KA 2RH6A 1SHQA 5L0EA 1ANJA 1ANIA 5INHA 3T00A 5K4PA 4KAYA 5EGEA 3IGYB 4KAVA 3MK0A 3M8WA 3NKNA 3OT9A 3UN3A 1AUKA 1AJBA 4UORA 1Y7AA 5EGHA 4MY4A 3WAVA 5IJQA 5GRRA 4CXSA 4LRAA 1E1ZP 4GTZA 1HDHA 1EW8A 3SZYA 3WAXA 5L0BA 1ALJA 4ZGAA 1B8JA 3BDGA 1ED9A 1AJCA 3E2DA 4NWXA 4UPKA 4FDIA 3WBHA 3BDFA 1E3CP 3M8ZA 2ZKTA 4GTWA 4UOOA 2W5SA 1E33P 3CMRA 3DYCA 5LQQA 2VQRA 4LQYA 3IGZB 3A52A 4CYRA 3WAWA 2GLQA 5TJ3A 4LR7A 3UN2A 2W5RA 3NKQA 1KHLA 3Q3QA 3TG0A 1ZEFA 1Y6VA 2QZUA 4N7TA 2GSUA 4UOPA 3M7VA 4ZG9A 1EW2A 2W5XA 2W5QA 1E2SP 2D1GA 4CXUA 1URBA 3KD8A 5LRNA 5HRTA 3MK2A 1EW9A 4LR2A 5DLVA 3NVLA 4KJGA 1EI6A 2W5TA 5LRMA 1K7HA 3B5QA 4B56A 2IUCA 2IFYA 3NKMA 2GA3A 4NWJA 3T01A 4ZG6A 1ALKA 2G9YA 2W5VA 4LREA 1KHJA 5DLWA 1URAA 1KHNA 3BDGB 5C66A 1ELYA 3IDDA 1KHKA 3NKPA 4GTYA 3UNYA 1P49A 1N2KA 1KH5A 4MIVA 4YR1A 1ZEDA 2GSNA 3SZZA
chains in the Genus database with same CATH topology
2ANHA 5KXAA 4LRCA 1AJDA 1EQJA 1N2LA 1ALIA 1AJAA 1O98A 3NKOA 5LIAA 1ELXA 1KH4A 4UPLA 4LRBA 4TN0A 2X98A 3MK1A 4KJDA 4QAXA 3UN5A 1ED8A 3NKRA 4CXKA 3LXQA 1KH7A 4KM4A 1EJJA 1KH9A 2XR9A 1FSUA 1O99A 4UPIA 4LRFA 1ELZA 4GTXA 4LR9A 4UPHA 3WAYA 3TWZA 3BDHA 2GSOA 3TX0A 2W8SA 5GOVA 5DLTA 4FDJA 1HJKA 1ALHA 4MHXA 1SHNA 1HQAA 5AJ9A 1ZEBA 3DPCA 4CYSA 3UO0A 3M8YA 3T02A 2XRGA 4LR8A 2IUCB 3ED4A 2W5WA 4ZG7A 2W8DA 5IJSA 4LRDA 5L0KA 2RH6A 1SHQA 5L0EA 1ANJA 1ANIA 5INHA 3T00A 5K4PA 4KAYA 5EGEA 3IGYB 4KAVA 3MK0A 3M8WA 3NKNA 3OT9A 3UN3A 1AUKA 1AJBA 4UORA 1Y7AA 5EGHA 4MY4A 3WAVA 5IJQA 5GRRA 4CXSA 4LRAA 1E1ZP 4GTZA 1HDHA 1EW8A 3SZYA 3WAXA 5L0BA 1ALJA 4ZGAA 1B8JA 3BDGA 1ED9A 1AJCA 3E2DA 4NWXA 4UPKA 4FDIA 3WBHA 3BDFA 1E3CP 3M8ZA 2ZKTA 4GTWA 4UOOA 2W5SA 1E33P 3CMRA 3DYCA 5LQQA 2VQRA 4LQYA 3IGZB 3A52A 4CYRA 3WAWA 2GLQA 5TJ3A 4LR7A 3UN2A 2W5RA 3NKQA 1KHLA 3Q3QA 3TG0A 1ZEFA 1Y6VA 2QZUA 4N7TA 2GSUA 4UOPA 3M7VA 4ZG9A 1EW2A 2W5XA 2W5QA 1E2SP 2D1GA 4CXUA 1URBA 3KD8A 5LRNA 5HRTA 3MK2A 1EW9A 4LR2A 5DLVA 3NVLA 4KJGA 1EI6A 2W5TA 5LRMA 1K7HA 3B5QA 4B56A 2IUCA 2IFYA 3NKMA 2GA3A 4NWJA 3T01A 4ZG6A 1ALKA 2G9YA 2W5VA 4LREA 1KHJA 5DLWA 1URAA 1KHNA 3BDGB 5C66A 1ELYA 3IDDA 1KHKA 3NKPA 4GTYA 3UNYA 1P49A 1N2KA 1KH5A 4MIVA 4YR1A 1ZEDA 2GSNA 3SZZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ANH A;  5KXA A;  4LRC A;  1AJD A;  1EQJ A;  1N2L A;  1ALI A;  1AJA A;  1O98 A;  3NKO A;  5LIA A;  1ELX A;  1KH4 A;  4UPL A;  4LRB A;  4TN0 A;  2X98 A;  3MK1 A;  4KJD A;  4QAX A;  3UN5 A;  1ED8 A;  3NKR A;  4CXK A;  3LXQ A;  1KH7 A;  4KM4 A;  1EJJ A;  1KH9 A;  2XR9 A;  1FSU A;  1O99 A;  4UPI A;  4LRF A;  1ELZ A;  4GTX A;  4LR9 A;  4UPH A;  3WAY A;  3TWZ A;  3BDH A;  2GSO A;  3TX0 A;  2W8S A;  5GOV A;  5DLT A;  4FDJ A;  1HJK A;  1ALH A;  4MHX A;  1SHN A;  1HQA A;  5AJ9 A;  1ZEB A;  3DPC A;  4CYS A;  3UO0 A;  3M8Y A;  3T02 A;  2XRG A;  4LR8 A;  2IUC B;  3ED4 A;  2W5W A;  4ZG7 A;  2W8D A;  5IJS A;  4LRD A;  5L0K A;  2RH6 A;  1SHQ A;  5L0E A;  1ANJ A;  1ANI A;  5INH A;  3T00 A;  5K4P A;  4KAY A;  5EGE A;  3IGY B;  4KAV A;  3MK0 A;  3M8W A;  3NKN A;  3OT9 A;  3UN3 A;  1AUK A;  1AJB A;  4UOR A;  1Y7A A;  5EGH A;  4MY4 A;  3WAV A;  5IJQ A;  5GRR A;  4CXS A;  4LRA A;  1E1Z P;  4GTZ A;  1HDH A;  1EW8 A;  3SZY A;  3WAX A;  5L0B A;  1ALJ A;  4ZGA A;  1B8J A;  3BDG A;  1ED9 A;  1AJC A;  3E2D A;  4NWX A;  4UPK A;  4FDI A;  3WBH A;  3BDF A;  1E3C P;  3M8Z A;  2ZKT A;  4GTW A;  4UOO A;  2W5S A;  1E33 P;  3CMR A;  3DYC A;  5LQQ A;  2VQR A;  4LQY A;  3IGZ B;  3A52 A;  4CYR A;  3WAW A;  2GLQ A;  5TJ3 A;  4LR7 A;  3UN2 A;  2W5R A;  3NKQ A;  1KHL A;  3Q3Q A;  3TG0 A;  1ZEF A;  1Y6V A;  2QZU A;  4N7T A;  2GSU A;  4UOP A;  3M7V A;  4ZG9 A;  1EW2 A;  2W5X A;  2W5Q A;  1E2S P;  2D1G A;  4CXU A;  1URB A;  3KD8 A;  5LRN A;  5HRT A;  3MK2 A;  1EW9 A;  4LR2 A;  5DLV A;  3NVL A;  4KJG A;  1EI6 A;  2W5T A;  5LRM A;  1K7H A;  3B5Q A;  4B56 A;  2IUC A;  2IFY A;  3NKM A;  2GA3 A;  4NWJ A;  3T01 A;  4ZG6 A;  1ALK A;  2G9Y A;  2W5V A;  4LRE A;  1KHJ A;  5DLW A;  1URA A;  1KHN A;  3BDG B;  5C66 A;  1ELY A;  3IDD A;  1KHK A;  3NKP A;  4GTY A;  3UNY A;  1P49 A;  1N2K A;  1KH5 A;  4MIV A;  4YR1 A;  1ZED A;  2GSN A;  3SZZ A; 
#chains in the Genus database with same CATH topology
 2ANH A;  5KXA A;  4LRC A;  1AJD A;  1EQJ A;  1N2L A;  1ALI A;  1AJA A;  1O98 A;  3NKO A;  5LIA A;  1ELX A;  1KH4 A;  4UPL A;  4LRB A;  4TN0 A;  2X98 A;  3MK1 A;  4KJD A;  4QAX A;  3UN5 A;  1ED8 A;  3NKR A;  4CXK A;  3LXQ A;  1KH7 A;  4KM4 A;  1EJJ A;  1KH9 A;  2XR9 A;  1FSU A;  1O99 A;  4UPI A;  4LRF A;  1ELZ A;  4GTX A;  4LR9 A;  4UPH A;  3WAY A;  3TWZ A;  3BDH A;  2GSO A;  3TX0 A;  2W8S A;  5GOV A;  5DLT A;  4FDJ A;  1HJK A;  1ALH A;  4MHX A;  1SHN A;  1HQA A;  5AJ9 A;  1ZEB A;  3DPC A;  4CYS A;  3UO0 A;  3M8Y A;  3T02 A;  2XRG A;  4LR8 A;  2IUC B;  3ED4 A;  2W5W A;  4ZG7 A;  2W8D A;  5IJS A;  4LRD A;  5L0K A;  2RH6 A;  1SHQ A;  5L0E A;  1ANJ A;  1ANI A;  5INH A;  3T00 A;  5K4P A;  4KAY A;  5EGE A;  3IGY B;  4KAV A;  3MK0 A;  3M8W A;  3NKN A;  3OT9 A;  3UN3 A;  1AUK A;  1AJB A;  4UOR A;  1Y7A A;  5EGH A;  4MY4 A;  3WAV A;  5IJQ A;  5GRR A;  4CXS A;  4LRA A;  1E1Z P;  4GTZ A;  1HDH A;  1EW8 A;  3SZY A;  3WAX A;  5L0B A;  1ALJ A;  4ZGA A;  1B8J A;  3BDG A;  1ED9 A;  1AJC A;  3E2D A;  4NWX A;  4UPK A;  4FDI A;  3WBH A;  3BDF A;  1E3C P;  3M8Z A;  2ZKT A;  4GTW A;  4UOO A;  2W5S A;  1E33 P;  3CMR A;  3DYC A;  5LQQ A;  2VQR A;  4LQY A;  3IGZ B;  3A52 A;  4CYR A;  3WAW A;  2GLQ A;  5TJ3 A;  4LR7 A;  3UN2 A;  2W5R A;  3NKQ A;  1KHL A;  3Q3Q A;  3TG0 A;  1ZEF A;  1Y6V A;  2QZU A;  4N7T A;  2GSU A;  4UOP A;  3M7V A;  4ZG9 A;  1EW2 A;  2W5X A;  2W5Q A;  1E2S P;  2D1G A;  4CXU A;  1URB A;  3KD8 A;  5LRN A;  5HRT A;  3MK2 A;  1EW9 A;  4LR2 A;  5DLV A;  3NVL A;  4KJG A;  1EI6 A;  2W5T A;  5LRM A;  1K7H A;  3B5Q A;  4B56 A;  2IUC A;  2IFY A;  3NKM A;  2GA3 A;  4NWJ A;  3T01 A;  4ZG6 A;  1ALK A;  2G9Y A;  2W5V A;  4LRE A;  1KHJ A;  5DLW A;  1URA A;  1KHN A;  3BDG B;  5C66 A;  1ELY A;  3IDD A;  1KHK A;  3NKP A;  4GTY A;  3UNY A;  1P49 A;  1N2K A;  1KH5 A;  4MIV A;  4YR1 A;  1ZED A;  2GSN A;  3SZZ A; 
#chains in the Genus database with same CATH homology
 2ANH A;  5KXA A;  4LRC A;  1AJD A;  1EQJ A;  1N2L A;  1ALI A;  1AJA A;  1O98 A;  3NKO A;  5LIA A;  1ELX A;  1KH4 A;  4UPL A;  4LRB A;  4TN0 A;  2X98 A;  3MK1 A;  4KJD A;  4QAX A;  3UN5 A;  1ED8 A;  3NKR A;  4CXK A;  3LXQ A;  1KH7 A;  4KM4 A;  1EJJ A;  1KH9 A;  2XR9 A;  1FSU A;  1O99 A;  4UPI A;  4LRF A;  1ELZ A;  4GTX A;  4LR9 A;  4UPH A;  3WAY A;  3TWZ A;  3BDH A;  2GSO A;  3TX0 A;  2W8S A;  5GOV A;  5DLT A;  4FDJ A;  1HJK A;  1ALH A;  4MHX A;  1SHN A;  1HQA A;  5AJ9 A;  1ZEB A;  3DPC A;  4CYS A;  3UO0 A;  3M8Y A;  3T02 A;  2XRG A;  4LR8 A;  2IUC B;  3ED4 A;  2W5W A;  4ZG7 A;  2W8D A;  5IJS A;  4LRD A;  5L0K A;  2RH6 A;  1SHQ A;  5L0E A;  1ANJ A;  1ANI A;  5INH A;  3T00 A;  5K4P A;  4KAY A;  5EGE A;  3IGY B;  4KAV A;  3MK0 A;  3M8W A;  3NKN A;  3OT9 A;  3UN3 A;  1AUK A;  1AJB A;  4UOR A;  1Y7A A;  5EGH A;  4MY4 A;  3WAV A;  5IJQ A;  5GRR A;  4CXS A;  4LRA A;  1E1Z P;  4GTZ A;  1HDH A;  1EW8 A;  3SZY A;  3WAX A;  5L0B A;  1ALJ A;  4ZGA A;  1B8J A;  3BDG A;  1ED9 A;  1AJC A;  3E2D A;  4NWX A;  4UPK A;  4FDI A;  3WBH A;  3BDF A;  1E3C P;  3M8Z A;  2ZKT A;  4GTW A;  4UOO A;  2W5S A;  1E33 P;  3CMR A;  3DYC A;  5LQQ A;  2VQR A;  4LQY A;  3IGZ B;  3A52 A;  4CYR A;  3WAW A;  2GLQ A;  5TJ3 A;  4LR7 A;  3UN2 A;  2W5R A;  3NKQ A;  1KHL A;  3Q3Q A;  3TG0 A;  1ZEF A;  1Y6V A;  2QZU A;  4N7T A;  2GSU A;  4UOP A;  3M7V A;  4ZG9 A;  1EW2 A;  2W5X A;  2W5Q A;  1E2S P;  2D1G A;  4CXU A;  1URB A;  3KD8 A;  5LRN A;  5HRT A;  3MK2 A;  1EW9 A;  4LR2 A;  5DLV A;  3NVL A;  4KJG A;  1EI6 A;  2W5T A;  5LRM A;  1K7H A;  3B5Q A;  4B56 A;  2IUC A;  2IFY A;  3NKM A;  2GA3 A;  4NWJ A;  3T01 A;  4ZG6 A;  1ALK A;  2G9Y A;  2W5V A;  4LRE A;  1KHJ A;  5DLW A;  1URA A;  1KHN A;  3BDG B;  5C66 A;  1ELY A;  3IDD A;  1KHK A;  3NKP A;  4GTY A;  3UNY A;  1P49 A;  1N2K A;  1KH5 A;  4MIV A;  4YR1 A;  1ZED A;  2GSN A;  3SZZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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