1ANIA

Alkaline phosphatase (d153h, k328h)
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDHQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
molecule keywords ALKALINE PHOSPHATASE
total genus 161
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-09-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1aniA00
3NKNA 1O99A 3M7VA 4UPIA 4ZG6A 4KJDA 4KJGA 4UPKA 4GTWA 3UN2A 1KH5A 4CXUA 1ALKA 5DLTA 1SHQA 3MK2A 4GTYA 1ED8A 5DLWA 1P49A 3NKRA 2QZUA 4LR7A 4LR8A 3DYCA 1E1ZP 3ED4A 5K4PA 2XR9A 2GSOA 5KXAA 3WBHA 3NKOA 4LRDA 2IUCB 3IGYB 4MIVA 2W5SA 1URBA 1SHNA 2ZKTA 4CYSA 2W8DA 3MK1A 5INHA 3BDGB 3UN3A 4MY4A 5GOVA 2W5RA 5LIAA 2W5WA 3KD8A 1ZEFA 4YR1A 1HQAA 3DPCA 2ANHA 4LQYA 1Y7AA 2D1GA 3M8YA 3TX0A 3TWZA 2W5XA 4GTXA 5EGHA 1FSUA 1KHJA 3TG0A 2W5QA 4LRCA 3IGZB 1AJBA 1ELXA 2X98A 1KHKA 1E3CP 3NKQA 2G9YA 4CXKA 3SZYA 5LQQA 3BDGA 1ALIA 3BDHA 4NWJA 4UPLA 3M8ZA 4LRAA 4KAVA 5L0KA 3UO0A 1EI6A 2GA3A 3M8WA 2IUCA 2W5VA 4TN0A 3T02A 1N2KA 1EW2A 3OT9A 4LREA 3UN5A 1EJJA 1KH9A 1N2LA 4LRBA 1ANIA 5LRMA 5IJQA 2GLQA 4FDJA 3Q3QA 5HRTA 5C66A 4LRFA 3WAWA 1KH7A 1ELYA 3T00A 5AJ9A 4CYRA 2XRGA 3NVLA 5DLVA 4UOPA 3NKPA 3B5QA 3E2DA 3LXQA 4UORA 1ED9A 4LR2A 1KHNA 3SZZA 1ALJA 4KAYA 1AUKA 1B8JA 1AJCA 1ALHA 2GSNA 1E2SP 1KH4A 4QAXA 4KM4A 2RH6A 1AJDA 4NWXA 4N7TA 1ELZA 1ZEDA 3WAXA 1HJKA 4LR9A 2W5TA 4ZGAA 4FDIA 2W8SA 4GTZA 1E33P 3T01A 4ZG7A 3WAYA 1EW9A 2IFYA 5GRRA 1HDHA 4CXSA 4B56A 1ANJA 1URAA 1EW8A 2VQRA 5TJ3A 4UPHA 3WAVA 4MHXA 5LRNA 1KHLA 3BDFA 3UNYA 4ZG9A 1O98A 5IJSA 3MK0A 1AJAA 1EQJA 5L0BA 4UOOA 3CMRA 3IDDA 5L0EA 3A52A 3NKMA 5EGEA 2GSUA 1K7HA 1ZEBA 1Y6VA
chains in the Genus database with same CATH superfamily
3NKNA 1O99A 3M7VA 4UPIA 4ZG6A 4KJDA 4KJGA 4UPKA 4GTWA 3UN2A 1KH5A 4CXUA 1ALKA 5DLTA 1SHQA 3MK2A 4GTYA 1ED8A 5DLWA 1P49A 3NKRA 2QZUA 4LR7A 4LR8A 3DYCA 1E1ZP 3ED4A 5K4PA 2XR9A 2GSOA 5KXAA 3WBHA 3NKOA 4LRDA 2IUCB 3IGYB 4MIVA 2W5SA 1URBA 1SHNA 2ZKTA 4CYSA 2W8DA 3MK1A 5INHA 3BDGB 3UN3A 4MY4A 5GOVA 2W5RA 5LIAA 2W5WA 3KD8A 1ZEFA 4YR1A 1HQAA 3DPCA 2ANHA 4LQYA 1Y7AA 2D1GA 3M8YA 3TX0A 3TWZA 2W5XA 4GTXA 5EGHA 1FSUA 1KHJA 3TG0A 2W5QA 4LRCA 3IGZB 1AJBA 1ELXA 2X98A 1KHKA 1E3CP 3NKQA 2G9YA 4CXKA 3SZYA 5LQQA 3BDGA 1ALIA 3BDHA 4NWJA 4UPLA 3M8ZA 4LRAA 4KAVA 5L0KA 3UO0A 1EI6A 2GA3A 3M8WA 2IUCA 2W5VA 4TN0A 3T02A 1N2KA 1EW2A 3OT9A 4LREA 3UN5A 1EJJA 1KH9A 1N2LA 4LRBA 1ANIA 5LRMA 5IJQA 2GLQA 4FDJA 3Q3QA 5HRTA 5C66A 4LRFA 3WAWA 1KH7A 1ELYA 3T00A 5AJ9A 4CYRA 2XRGA 3NVLA 5DLVA 4UOPA 3NKPA 3B5QA 3E2DA 3LXQA 4UORA 1ED9A 4LR2A 1KHNA 3SZZA 1ALJA 4KAYA 1AUKA 1B8JA 1AJCA 1ALHA 2GSNA 1E2SP 1KH4A 4QAXA 4KM4A 2RH6A 1AJDA 4NWXA 4N7TA 1ELZA 1ZEDA 3WAXA 1HJKA 4LR9A 2W5TA 4ZGAA 4FDIA 2W8SA 4GTZA 1E33P 3T01A 4ZG7A 3WAYA 1EW9A 2IFYA 5GRRA 1HDHA 4CXSA 4B56A 1ANJA 1URAA 1EW8A 2VQRA 5TJ3A 4UPHA 3WAVA 4MHXA 5LRNA 1KHLA 3BDFA 3UNYA 4ZG9A 1O98A 5IJSA 3MK0A 1AJAA 1EQJA 5L0BA 4UOOA 3CMRA 3IDDA 5L0EA 3A52A 3NKMA 5EGEA 2GSUA 1K7HA 1ZEBA 1Y6VA
chains in the Genus database with same CATH topology
3NKNA 1O99A 3M7VA 4UPIA 4ZG6A 4KJDA 4KJGA 4UPKA 4GTWA 3UN2A 1KH5A 4CXUA 1ALKA 5DLTA 1SHQA 3MK2A 4GTYA 1ED8A 5DLWA 1P49A 3NKRA 2QZUA 4LR7A 4LR8A 3DYCA 1E1ZP 3ED4A 5K4PA 2XR9A 2GSOA 5KXAA 3WBHA 3NKOA 4LRDA 2IUCB 3IGYB 4MIVA 2W5SA 1URBA 1SHNA 2ZKTA 4CYSA 2W8DA 3MK1A 5INHA 3BDGB 3UN3A 4MY4A 5GOVA 2W5RA 5LIAA 2W5WA 3KD8A 1ZEFA 4YR1A 1HQAA 3DPCA 2ANHA 4LQYA 1Y7AA 2D1GA 3M8YA 3TX0A 3TWZA 2W5XA 4GTXA 5EGHA 1FSUA 1KHJA 3TG0A 2W5QA 4LRCA 3IGZB 1AJBA 1ELXA 2X98A 1KHKA 1E3CP 3NKQA 2G9YA 4CXKA 3SZYA 5LQQA 3BDGA 1ALIA 3BDHA 4NWJA 4UPLA 3M8ZA 4LRAA 4KAVA 5L0KA 3UO0A 1EI6A 2GA3A 3M8WA 2IUCA 2W5VA 4TN0A 3T02A 1N2KA 1EW2A 3OT9A 4LREA 3UN5A 1EJJA 1KH9A 1N2LA 4LRBA 1ANIA 5LRMA 5IJQA 2GLQA 4FDJA 3Q3QA 5HRTA 5C66A 4LRFA 3WAWA 1KH7A 1ELYA 3T00A 5AJ9A 4CYRA 2XRGA 3NVLA 5DLVA 4UOPA 3NKPA 3B5QA 3E2DA 3LXQA 4UORA 1ED9A 4LR2A 1KHNA 3SZZA 1ALJA 4KAYA 1AUKA 1B8JA 1AJCA 1ALHA 2GSNA 1E2SP 1KH4A 4QAXA 4KM4A 2RH6A 1AJDA 4NWXA 4N7TA 1ELZA 1ZEDA 3WAXA 1HJKA 4LR9A 2W5TA 4ZGAA 4FDIA 2W8SA 4GTZA 1E33P 3T01A 4ZG7A 3WAYA 1EW9A 2IFYA 5GRRA 1HDHA 4CXSA 4B56A 1ANJA 1URAA 1EW8A 2VQRA 5TJ3A 4UPHA 3WAVA 4MHXA 5LRNA 1KHLA 3BDFA 3UNYA 4ZG9A 1O98A 5IJSA 3MK0A 1AJAA 1EQJA 5L0BA 4UOOA 3CMRA 3IDDA 5L0EA 3A52A 3NKMA 5EGEA 2GSUA 1K7HA 1ZEBA 1Y6VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NKN A;  1O99 A;  3M7V A;  4UPI A;  4ZG6 A;  4KJD A;  4KJG A;  4UPK A;  4GTW A;  3UN2 A;  1KH5 A;  4CXU A;  1ALK A;  5DLT A;  1SHQ A;  3MK2 A;  4GTY A;  1ED8 A;  5DLW A;  1P49 A;  3NKR A;  2QZU A;  4LR7 A;  4LR8 A;  3DYC A;  1E1Z P;  3ED4 A;  5K4P A;  2XR9 A;  2GSO A;  5KXA A;  3WBH A;  3NKO A;  4LRD A;  2IUC B;  3IGY B;  4MIV A;  2W5S A;  1URB A;  1SHN A;  2ZKT A;  4CYS A;  2W8D A;  3MK1 A;  5INH A;  3BDG B;  3UN3 A;  4MY4 A;  5GOV A;  2W5R A;  5LIA A;  2W5W A;  3KD8 A;  1ZEF A;  4YR1 A;  1HQA A;  3DPC A;  2ANH A;  4LQY A;  1Y7A A;  2D1G A;  3M8Y A;  3TX0 A;  3TWZ A;  2W5X A;  4GTX A;  5EGH A;  1FSU A;  1KHJ A;  3TG0 A;  2W5Q A;  4LRC A;  3IGZ B;  1AJB A;  1ELX A;  2X98 A;  1KHK A;  1E3C P;  3NKQ A;  2G9Y A;  4CXK A;  3SZY A;  5LQQ A;  3BDG A;  1ALI A;  3BDH A;  4NWJ A;  4UPL A;  3M8Z A;  4LRA A;  4KAV A;  5L0K A;  3UO0 A;  1EI6 A;  2GA3 A;  3M8W A;  2IUC A;  2W5V A;  4TN0 A;  3T02 A;  1N2K A;  1EW2 A;  3OT9 A;  4LRE A;  3UN5 A;  1EJJ A;  1KH9 A;  1N2L A;  4LRB A;  1ANI A;  5LRM A;  5IJQ A;  2GLQ A;  4FDJ A;  3Q3Q A;  5HRT A;  5C66 A;  4LRF A;  3WAW A;  1KH7 A;  1ELY A;  3T00 A;  5AJ9 A;  4CYR A;  2XRG A;  3NVL A;  5DLV A;  4UOP A;  3NKP A;  3B5Q A;  3E2D A;  3LXQ A;  4UOR A;  1ED9 A;  4LR2 A;  1KHN A;  3SZZ A;  1ALJ A;  4KAY A;  1AUK A;  1B8J A;  1AJC A;  1ALH A;  2GSN A;  1E2S P;  1KH4 A;  4QAX A;  4KM4 A;  2RH6 A;  1AJD A;  4NWX A;  4N7T A;  1ELZ A;  1ZED A;  3WAX A;  1HJK A;  4LR9 A;  2W5T A;  4ZGA A;  4FDI A;  2W8S A;  4GTZ A;  1E33 P;  3T01 A;  4ZG7 A;  3WAY A;  1EW9 A;  2IFY A;  5GRR A;  1HDH A;  4CXS A;  4B56 A;  1ANJ A;  1URA A;  1EW8 A;  2VQR A;  5TJ3 A;  4UPH A;  3WAV A;  4MHX A;  5LRN A;  1KHL A;  3BDF A;  3UNY A;  4ZG9 A;  1O98 A;  5IJS A;  3MK0 A;  1AJA A;  1EQJ A;  5L0B A;  4UOO A;  3CMR A;  3IDD A;  5L0E A;  3A52 A;  3NKM A;  5EGE A;  2GSU A;  1K7H A;  1ZEB A;  1Y6V A; 
#chains in the Genus database with same CATH topology
 3NKN A;  1O99 A;  3M7V A;  4UPI A;  4ZG6 A;  4KJD A;  4KJG A;  4UPK A;  4GTW A;  3UN2 A;  1KH5 A;  4CXU A;  1ALK A;  5DLT A;  1SHQ A;  3MK2 A;  4GTY A;  1ED8 A;  5DLW A;  1P49 A;  3NKR A;  2QZU A;  4LR7 A;  4LR8 A;  3DYC A;  1E1Z P;  3ED4 A;  5K4P A;  2XR9 A;  2GSO A;  5KXA A;  3WBH A;  3NKO A;  4LRD A;  2IUC B;  3IGY B;  4MIV A;  2W5S A;  1URB A;  1SHN A;  2ZKT A;  4CYS A;  2W8D A;  3MK1 A;  5INH A;  3BDG B;  3UN3 A;  4MY4 A;  5GOV A;  2W5R A;  5LIA A;  2W5W A;  3KD8 A;  1ZEF A;  4YR1 A;  1HQA A;  3DPC A;  2ANH A;  4LQY A;  1Y7A A;  2D1G A;  3M8Y A;  3TX0 A;  3TWZ A;  2W5X A;  4GTX A;  5EGH A;  1FSU A;  1KHJ A;  3TG0 A;  2W5Q A;  4LRC A;  3IGZ B;  1AJB A;  1ELX A;  2X98 A;  1KHK A;  1E3C P;  3NKQ A;  2G9Y A;  4CXK A;  3SZY A;  5LQQ A;  3BDG A;  1ALI A;  3BDH A;  4NWJ A;  4UPL A;  3M8Z A;  4LRA A;  4KAV A;  5L0K A;  3UO0 A;  1EI6 A;  2GA3 A;  3M8W A;  2IUC A;  2W5V A;  4TN0 A;  3T02 A;  1N2K A;  1EW2 A;  3OT9 A;  4LRE A;  3UN5 A;  1EJJ A;  1KH9 A;  1N2L A;  4LRB A;  1ANI A;  5LRM A;  5IJQ A;  2GLQ A;  4FDJ A;  3Q3Q A;  5HRT A;  5C66 A;  4LRF A;  3WAW A;  1KH7 A;  1ELY A;  3T00 A;  5AJ9 A;  4CYR A;  2XRG A;  3NVL A;  5DLV A;  4UOP A;  3NKP A;  3B5Q A;  3E2D A;  3LXQ A;  4UOR A;  1ED9 A;  4LR2 A;  1KHN A;  3SZZ A;  1ALJ A;  4KAY A;  1AUK A;  1B8J A;  1AJC A;  1ALH A;  2GSN A;  1E2S P;  1KH4 A;  4QAX A;  4KM4 A;  2RH6 A;  1AJD A;  4NWX A;  4N7T A;  1ELZ A;  1ZED A;  3WAX A;  1HJK A;  4LR9 A;  2W5T A;  4ZGA A;  4FDI A;  2W8S A;  4GTZ A;  1E33 P;  3T01 A;  4ZG7 A;  3WAY A;  1EW9 A;  2IFY A;  5GRR A;  1HDH A;  4CXS A;  4B56 A;  1ANJ A;  1URA A;  1EW8 A;  2VQR A;  5TJ3 A;  4UPH A;  3WAV A;  4MHX A;  5LRN A;  1KHL A;  3BDF A;  3UNY A;  4ZG9 A;  1O98 A;  5IJS A;  3MK0 A;  1AJA A;  1EQJ A;  5L0B A;  4UOO A;  3CMR A;  3IDD A;  5L0E A;  3A52 A;  3NKM A;  5EGE A;  2GSU A;  1K7H A;  1ZEB A;  1Y6V A; 
#chains in the Genus database with same CATH homology
 3NKN A;  1O99 A;  3M7V A;  4UPI A;  4ZG6 A;  4KJD A;  4KJG A;  4UPK A;  4GTW A;  3UN2 A;  1KH5 A;  4CXU A;  1ALK A;  5DLT A;  1SHQ A;  3MK2 A;  4GTY A;  1ED8 A;  5DLW A;  1P49 A;  3NKR A;  2QZU A;  4LR7 A;  4LR8 A;  3DYC A;  1E1Z P;  3ED4 A;  5K4P A;  2XR9 A;  2GSO A;  5KXA A;  3WBH A;  3NKO A;  4LRD A;  2IUC B;  3IGY B;  4MIV A;  2W5S A;  1URB A;  1SHN A;  2ZKT A;  4CYS A;  2W8D A;  3MK1 A;  5INH A;  3BDG B;  3UN3 A;  4MY4 A;  5GOV A;  2W5R A;  5LIA A;  2W5W A;  3KD8 A;  1ZEF A;  4YR1 A;  1HQA A;  3DPC A;  2ANH A;  4LQY A;  1Y7A A;  2D1G A;  3M8Y A;  3TX0 A;  3TWZ A;  2W5X A;  4GTX A;  5EGH A;  1FSU A;  1KHJ A;  3TG0 A;  2W5Q A;  4LRC A;  3IGZ B;  1AJB A;  1ELX A;  2X98 A;  1KHK A;  1E3C P;  3NKQ A;  2G9Y A;  4CXK A;  3SZY A;  5LQQ A;  3BDG A;  1ALI A;  3BDH A;  4NWJ A;  4UPL A;  3M8Z A;  4LRA A;  4KAV A;  5L0K A;  3UO0 A;  1EI6 A;  2GA3 A;  3M8W A;  2IUC A;  2W5V A;  4TN0 A;  3T02 A;  1N2K A;  1EW2 A;  3OT9 A;  4LRE A;  3UN5 A;  1EJJ A;  1KH9 A;  1N2L A;  4LRB A;  1ANI A;  5LRM A;  5IJQ A;  2GLQ A;  4FDJ A;  3Q3Q A;  5HRT A;  5C66 A;  4LRF A;  3WAW A;  1KH7 A;  1ELY A;  3T00 A;  5AJ9 A;  4CYR A;  2XRG A;  3NVL A;  5DLV A;  4UOP A;  3NKP A;  3B5Q A;  3E2D A;  3LXQ A;  4UOR A;  1ED9 A;  4LR2 A;  1KHN A;  3SZZ A;  1ALJ A;  4KAY A;  1AUK A;  1B8J A;  1AJC A;  1ALH A;  2GSN A;  1E2S P;  1KH4 A;  4QAX A;  4KM4 A;  2RH6 A;  1AJD A;  4NWX A;  4N7T A;  1ELZ A;  1ZED A;  3WAX A;  1HJK A;  4LR9 A;  2W5T A;  4ZGA A;  4FDI A;  2W8S A;  4GTZ A;  1E33 P;  3T01 A;  4ZG7 A;  3WAY A;  1EW9 A;  2IFY A;  5GRR A;  1HDH A;  4CXS A;  4B56 A;  1ANJ A;  1URA A;  1EW8 A;  2VQR A;  5TJ3 A;  4UPH A;  3WAV A;  4MHX A;  5LRN A;  1KHL A;  3BDF A;  3UNY A;  4ZG9 A;  1O98 A;  5IJS A;  3MK0 A;  1AJA A;  1EQJ A;  5L0B A;  4UOO A;  3CMR A;  3IDD A;  5L0E A;  3A52 A;  3NKM A;  5EGE A;  2GSU A;  1K7H A;  1ZEB A;  1Y6V A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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