1AZYA

Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase
Total Genus 145
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
145
sequence length
440
structure length
440
Chain Sequence
LFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAAIKLADKAPESTPTVYRRISE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Glycosyltransferase
molecule keywords THYMIDINE PHOSPHORYLASE
publication title Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase.
pubmed doi rcsb
total genus 145
structure length 440
sequence length 440
chains with identical sequence B
ec nomenclature ec 2.4.2.4: Thymidine phosphorylase.
pdb deposition date 1997-11-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
A PF07831 PYNP_C Pyrimidine nucleoside phosphorylase C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 1azyA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 1azyA02
3.90.1170.30 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Pyrimidine nucleoside phosphorylase-like, C-terminal domain 1azyA03
3R6CA 4OWNA 1O17A 4IJ1A 2WK6A 4ZOJA 2WK5A 1VQUA 2TPTA 1GXBA 4YI7A 4GIUA 2BPQA 4N8QA 3QQSA 2DSJA 3TWPA 4X5AA 4X58A 4GTNA 5BNEA 4X5EA 1KGZA 4EADA 1ZVWA 1AZYA 2ELCA 4LHMA 1BRWA 4GA4A 4X59A 5EP8A 1KHDA 3QS8A 4X5CA 3R88A 4X5DA 4OWVA 5C1RA 5EY3A 2J0FA 5C7SA 3UU1A 5BO2A 4YEKA 4HKMA 2GVQA 4EAFA 3QSAA 4ZOKA 4MUOA 4OWUA 3QR9A 5BO3A 1V8GA 1ZXYA 4GA6A 1ZYKA 1UOUA 4ZTVA 4OWMA 4N93A 4GKMA 3GBRA 4YYYA 4OWQA 4X46A 4OWSA 4ZOFA 5C2LA 4X5BA 1OTPA 3H5QA 4GA5A 4M0RA 4OWOA 5BYTA 4N5VA 4XR5A
chains in the Genus database with same CATH superfamily
3R6CA 4OWNA 3WO1A 3CC7H 1RRZA 4C7YA 2WP4A 3AN1A 1FIQC 1ZXIB 5GAGN 1O17A 4IJ1A 3C2RA 1FO4A 1VLBA 2WK6A 2Q5WE 3B9JC 3NRZC 4WF9J 3G71H 4IOCJ 3NVWC 4US9A 4ZOJA 3PIOJ 3WO0A 2WK5A 1VQUA 1N5XA 3CCVH 1VQ6H 1K8AJ 3CXCH 3G4SH 1QPQA 1VQOH 5DM6J 1YJNH 2TPTA 5HL7J 1GXBA 2W54B 3AMZA 2QEXH 1KC8J 1FM0E 4YI7A 1N61B 3C2EA 5GAHN 2B7PA 4F3FC 1M1KJ 2W55B 4C80A 4AP8A 4GIUA 4KWVA 1YTDA 1VDVA 5AYYA 1V97A 5GADN 3CCLH 1Q7YJ 2ZJRJ 2BPQA 3EUB4 3CCMH 1FFVB 3BIIE 5AYZA 4N8QA 1N62B 5AYXA 3J7ZM 2B7QA 1QVGH 3QQSA 1VQKH 1VQNH 1KQSH 3C2OA 4US8A 1YJ9H 2DSJA 1O4UA 3TWPA 3CC4H 1SIJA 4X5AA 3I56H 1W2BH 4X58A 1RM6A 1VQ8H 3NVVC 3C2VA 4GTNA 2OTLH 5BNEA 4X5EA 1KGZA 1X1OA 4EADA 1FMAE 1JROB 3ETRC 4C7ZA 1ZVWA 2E3TA 1YITH 1VQ7H 5HUPA 5MLCO 3PIPJ 5JVGJ 1N60B 1QPRA 3CPWH 1M90J 1AZYA 1WKIA 3CCJH 2ELCA 4LHMA 3GNNA 3G6EH 1BRWA 3CC2H 3CCUH 1VQLH 4GA4A 4U67J 4WFNJ 1K9MJ 1Q81J 3RPFA 1NJIJ 3FAHA 5HULA 4UY8M 4X59A 4I9AA 5AN9F 5EP8A 2W3SB 3CF5J 1KHDA 1JJ2H 2PA2A 5JVHJ 3QS8A 4X5CA 3R88A 4X5DA 4OWVA 4ZOHA 5C1RA 1Y69K 3CMEH 3CMAH 5DM7J 1Q86J 4IOAJ 5HUOA 5EY3A 2J0FA 1K73J 2OTJH 5C7SA 2W3RB 1NVIE 1RF8B 1JRPB 3PAJA 3CCQH 3UU1A 5H1SO 5BO2A 4YEKA 4HKMA 2I1OA 4USAA 1DGJA 1N63B 2GVQA 4EAFA 3QSAA 3WNZA 4ZOKA 1S72H 4MUOA 4OWUA 3QR9A 5BO3A 1YJWH 1N8RJ 4WFAJ 1YHQH 1V8GA 1ZXYA 4GA6A 2I14A 3VMMA 4IO9J 1Q82J 3CCRH 1ZYKA 1QPNA 3DLLJ 1VQ5H 1UOUA 4ZTVA 4OWMA 2QA4H 1VQ4H 4N93A 3FC4A 1N5WB 3C2FA 3CD6H 4WCEJ 4GKMA 1QAPA 1VQPH 3GBRA 4KWWA 1YTKA 4YYYA 1WYGA 3OW2H 1FFUB 1YTEA 4OWQA 3TQVA 3SR6C 4X46A 2ZJPJ 3NVYC 4OWSA 4ZOFA 3NS1C 1SB3A 3AM9A 1QPOA 5C2LA 2ZJQJ 5GAEN 4X5BA 5MPOC 1KD1J 1OTPA 3CCSH 3H5QA 1VQMH 3NVZC 4GA5A 2QIEA 2B7NA 4M0RA 3L0GA 4WFBJ 1VQ9H 2JBMA 4OWOA 5BYTA 3CCEH 1YI2H 1NVJA 4N5VA 4XR5A 3I55H 1YIJH 2OMDA 1QVFH 3L4PA
chains in the Genus database with same CATH topology
3R6CA 4OWNA 1O17A 4IJ1A 2WK6A 4ZOJA 2WK5A 1VQUA 2TPTA 1GXBA 4YI7A 4GIUA 2BPQA 4N8QA 3QQSA 2DSJA 3TWPA 4X5AA 4X58A 4GTNA 5BNEA 4X5EA 1KGZA 4EADA 1ZVWA 1AZYA 2ELCA 4LHMA 1BRWA 4GA4A 4X59A 5EP8A 1KHDA 3QS8A 4X5CA 3R88A 4X5DA 4OWVA 5C1RA 5EY3A 2J0FA 5C7SA 3UU1A 5BO2A 4YEKA 4HKMA 2GVQA 4EAFA 3QSAA 4ZOKA 4MUOA 4OWUA 3QR9A 5BO3A 1V8GA 1ZXYA 4GA6A 1ZYKA 1UOUA 4ZTVA 4OWMA 4N93A 4GKMA 3GBRA 4YYYA 4OWQA 4X46A 4OWSA 4ZOFA 5C2LA 4X5BA 1OTPA 3H5QA 4GA5A 4M0RA 4OWOA 5BYTA 4N5VA 4XR5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3R6C A;  4OWN A;  1O17 A;  4IJ1 A;  2WK6 A;  4ZOJ A;  2WK5 A;  1VQU A;  2TPT A;  1GXB A;  4YI7 A;  4GIU A;  2BPQ A;  4N8Q A;  3QQS A;  2DSJ A;  3TWP A;  4X5A A;  4X58 A;  4GTN A;  5BNE A;  4X5E A;  1KGZ A;  4EAD A;  1ZVW A;  1AZY A;  2ELC A;  4LHM A;  1BRW A;  4GA4 A;  4X59 A;  5EP8 A;  1KHD A;  3QS8 A;  4X5C A;  3R88 A;  4X5D A;  4OWV A;  5C1R A;  5EY3 A;  2J0F A;  5C7S A;  3UU1 A;  5BO2 A;  4YEK A;  4HKM A;  2GVQ A;  4EAF A;  3QSA A;  4ZOK A;  4MUO A;  4OWU A;  3QR9 A;  5BO3 A;  1V8G A;  1ZXY A;  4GA6 A;  1ZYK A;  1UOU A;  4ZTV A;  4OWM A;  4N93 A;  4GKM A;  3GBR A;  4YYY A;  4OWQ A;  4X46 A;  4OWS A;  4ZOF A;  5C2L A;  4X5B A;  1OTP A;  3H5Q A;  4GA5 A;  4M0R A;  4OWO A;  5BYT A;  4N5V A;  4XR5 A; 
#chains in the Genus database with same CATH topology
 3R6C A;  4OWN A;  3WO1 A;  3CC7 H;  1RRZ A;  4C7Y A;  2WP4 A;  3AN1 A;  1FIQ C;  1ZXI B;  5GAG N;  1O17 A;  4IJ1 A;  3C2R A;  1FO4 A;  1VLB A;  2WK6 A;  2Q5W E;  3B9J C;  3NRZ C;  4WF9 J;  3G71 H;  4IOC J;  3NVW C;  4US9 A;  4ZOJ A;  3PIO J;  3WO0 A;  2WK5 A;  1VQU A;  1N5X A;  3CCV H;  1VQ6 H;  1K8A J;  3CXC H;  3G4S H;  1QPQ A;  1VQO H;  5DM6 J;  1YJN H;  2TPT A;  5HL7 J;  1GXB A;  2W54 B;  3AMZ A;  2QEX H;  1KC8 J;  1FM0 E;  4YI7 A;  1N61 B;  3C2E A;  5GAH N;  2B7P A;  4F3F C;  1M1K J;  2W55 B;  4C80 A;  4AP8 A;  4GIU A;  4KWV A;  1YTD A;  1VDV A;  5AYY A;  1V97 A;  5GAD N;  3CCL H;  1Q7Y J;  2ZJR J;  2BPQ A;  3EUB 4;  3CCM H;  1FFV B;  3BII E;  5AYZ A;  4N8Q A;  1N62 B;  5AYX A;  3J7Z M;  2B7Q A;  1QVG H;  3QQS A;  1VQK H;  1VQN H;  1KQS H;  3C2O A;  4US8 A;  1YJ9 H;  2DSJ A;  1O4U A;  3TWP A;  3CC4 H;  1SIJ A;  4X5A A;  3I56 H;  1W2B H;  4X58 A;  1RM6 A;  1VQ8 H;  3NVV C;  3C2V A;  4GTN A;  2OTL H;  5BNE A;  4X5E A;  1KGZ A;  1X1O A;  4EAD A;  1FMA E;  1JRO B;  3ETR C;  4C7Z A;  1ZVW A;  2E3T A;  1YIT H;  1VQ7 H;  5HUP A;  5MLC O;  3PIP J;  5JVG J;  1N60 B;  1QPR A;  3CPW H;  1M90 J;  1AZY A;  1WKI A;  3CCJ H;  2ELC A;  4LHM A;  3GNN A;  3G6E H;  1BRW A;  3CC2 H;  3CCU H;  1VQL H;  4GA4 A;  4U67 J;  4WFN J;  1K9M J;  1Q81 J;  3RPF A;  1NJI J;  3FAH A;  5HUL A;  4UY8 M;  4X59 A;  4I9A A;  5AN9 F;  5EP8 A;  2W3S B;  3CF5 J;  1KHD A;  1JJ2 H;  2PA2 A;  5JVH J;  3QS8 A;  4X5C A;  3R88 A;  4X5D A;  4OWV A;  4ZOH A;  5C1R A;  1Y69 K;  3CME H;  3CMA H;  5DM7 J;  1Q86 J;  4IOA J;  5HUO A;  5EY3 A;  2J0F A;  1K73 J;  2OTJ H;  5C7S A;  2W3R B;  1NVI E;  1RF8 B;  1JRP B;  3PAJ A;  3CCQ H;  3UU1 A;  5H1S O;  5BO2 A;  4YEK A;  4HKM A;  2I1O A;  4USA A;  1DGJ A;  1N63 B;  2GVQ A;  4EAF A;  3QSA A;  3WNZ A;  4ZOK A;  1S72 H;  4MUO A;  4OWU A;  3QR9 A;  5BO3 A;  1YJW H;  1N8R J;  4WFA J;  1YHQ H;  1V8G A;  1ZXY A;  4GA6 A;  2I14 A;  3VMM A;  4IO9 J;  1Q82 J;  3CCR H;  1ZYK A;  1QPN A;  3DLL J;  1VQ5 H;  1UOU A;  4ZTV A;  4OWM A;  2QA4 H;  1VQ4 H;  4N93 A;  3FC4 A;  1N5W B;  3C2F A;  3CD6 H;  4WCE J;  4GKM A;  1QAP A;  1VQP H;  3GBR A;  4KWW A;  1YTK A;  4YYY A;  1WYG A;  3OW2 H;  1FFU B;  1YTE A;  4OWQ A;  3TQV A;  3SR6 C;  4X46 A;  2ZJP J;  3NVY C;  4OWS A;  4ZOF A;  3NS1 C;  1SB3 A;  3AM9 A;  1QPO A;  5C2L A;  2ZJQ J;  5GAE N;  4X5B A;  5MPO C;  1KD1 J;  1OTP A;  3CCS H;  3H5Q A;  1VQM H;  3NVZ C;  4GA5 A;  2QIE A;  2B7N A;  4M0R A;  3L0G A;  4WFB J;  1VQ9 H;  2JBM A;  4OWO A;  5BYT A;  3CCE H;  1YI2 H;  1NVJ A;  4N5V A;  4XR5 A;  3I55 H;  1YIJ H;  2OMD A;  1QVF H;  3L4P A; 
#chains in the Genus database with same CATH homology
 3R6C A;  4OWN A;  1O17 A;  4IJ1 A;  2WK6 A;  4ZOJ A;  2WK5 A;  1VQU A;  2TPT A;  1GXB A;  4YI7 A;  4GIU A;  2BPQ A;  4N8Q A;  3QQS A;  2DSJ A;  3TWP A;  4X5A A;  4X58 A;  4GTN A;  5BNE A;  4X5E A;  1KGZ A;  4EAD A;  1ZVW A;  1AZY A;  2ELC A;  4LHM A;  1BRW A;  4GA4 A;  4X59 A;  5EP8 A;  1KHD A;  3QS8 A;  4X5C A;  3R88 A;  4X5D A;  4OWV A;  5C1R A;  5EY3 A;  2J0F A;  5C7S A;  3UU1 A;  5BO2 A;  4YEK A;  4HKM A;  2GVQ A;  4EAF A;  3QSA A;  4ZOK A;  4MUO A;  4OWU A;  3QR9 A;  5BO3 A;  1V8G A;  1ZXY A;  4GA6 A;  1ZYK A;  1UOU A;  4ZTV A;  4OWM A;  4N93 A;  4GKM A;  3GBR A;  4YYY A;  4OWQ A;  4X46 A;  4OWS A;  4ZOF A;  5C2L A;  4X5B A;  1OTP A;  3H5Q A;  4GA5 A;  4M0R A;  4OWO A;  5BYT A;  4N5V A;  4XR5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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