1B8JA

Alkaline phosphatase complexed with vanadate
Total Genus 163
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
Knots found
sequence length
449
structure length
448
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
publication title A model of the transition state in the alkaline phosphatase reaction.
pubmed doi rcsb
molecule keywords PROTEIN (ALKALINE PHOSPHATASE)
molecule tags Alkaline phosphatase
source organism Escherichia coli
total genus 163
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1999-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1b8jA00
3NKPA 3MK1A 3WBHA 1KHKA 3BDGA 3CMRA 3NVLA 2IUCB 4ZG9A 4CXSA 4LQYA 3T01A 1O99A 2GSUA 4UORA 3UN3A 4ZG6A 1O98A 1P49A 4CXKA 3T02A 2W5WA 3IDDA 5LRNA 1KHJA 4LR8A 1KHLA 3UO0A 2QZUA 3UNYA 4UPHA 5L0BA 4TN0A 3TG0A 1HDHA 5DLVA 1Y7AA 1FSUA 4GTWA 4UOOA 4FDJA 5TJ3A 1Y6VA 1ALIA 3BDGB 3Q3QA 1ANJA 4B56A 2GSOA 5LRMA 3NKMA 1AUKA 3M8YA 4GTXA 2XRGA 1ZEFA 1KHNA 1URBA 5IJQA 2G9YA 2XR9A 1EI6A 3WAWA 5DLWA 1EQJA 1EW9A 1AJBA 3WAYA 2W5VA 1KH7A 1HQAA 4FDIA 1E1ZP 4KAYA 4UOPA 4NWXA 4MIVA 2GA3A 2GSNA 5GRRA 2RH6A 3TWZA 5L0EA 3NKOA 2GLQA 4LRDA 4CYRA 1SHNA 2ANHA 1ZEDA 3IGZB 4UPLA 1K7HA 1SHQA 4N7TA 4UPIA 3NKQA 5EGHA 1AJDA 4LRFA 5IJSA 1ED9A 1EW8A 1AJCA 4YR1A 1ANIA 4NWJA 1E2SP 3IGYB 4KAVA 5EGEA 3B5QA 5GOVA 1EW2A 5L0KA 3DPCA 4LRCA 5KXAA 3SZYA 4UPKA 4LR2A 4MHXA 3WAXA 1ELXA 4LR7A 2IUCA 1KH4A 5C66A 3NKNA 4KJDA 3DYCA 3M7VA 5LQQA 1HJKA 1ZEBA 3NKRA 2W8SA 2W5SA 4MY4A 3TX0A 1ALHA 3WAVA 1ELYA 3A52A 3E2DA 3M8WA 3OT9A 3LXQA 4LRBA 3MK0A 1ALKA 2VQRA 2X98A 1KH9A 4CYSA 4LR9A 1URAA 5LIAA 1ALJA 4KJGA 1B8JA 1KH5A 3ED4A 1N2KA 3KD8A 4KM4A 2W5QA 5DLTA 2IFYA 1N2LA 4ZGAA 1EJJA 1AJAA 4GTZA 1ED8A 5K4PA 3M8ZA 2W8DA 3UN5A 4ZG7A 3T00A 3SZZA 2W5RA 1E33P 1ELZA 4QAXA 5AJ9A 4GTYA 5INHA 1E3CP 3BDHA 2W5XA 3BDFA 3MK2A 4LREA 2W5TA 5HRTA 2D1GA 4LRAA 3UN2A 4CXUA 2ZKTA
chains in the Genus database with same CATH superfamily
3NKPA 3MK1A 3WBHA 1KHKA 3BDGA 3CMRA 3NVLA 2IUCB 4ZG9A 4CXSA 4LQYA 3T01A 1O99A 2GSUA 4UORA 3UN3A 4ZG6A 1O98A 1P49A 4CXKA 3T02A 2W5WA 3IDDA 5LRNA 1KHJA 4LR8A 1KHLA 3UO0A 2QZUA 3UNYA 4UPHA 5L0BA 4TN0A 3TG0A 1HDHA 5DLVA 1Y7AA 1FSUA 4GTWA 4UOOA 4FDJA 5TJ3A 1Y6VA 1ALIA 3BDGB 3Q3QA 1ANJA 4B56A 2GSOA 5LRMA 3NKMA 1AUKA 3M8YA 4GTXA 2XRGA 1ZEFA 1KHNA 1URBA 5IJQA 2G9YA 2XR9A 1EI6A 3WAWA 5DLWA 1EQJA 1EW9A 1AJBA 3WAYA 2W5VA 1KH7A 1HQAA 4FDIA 1E1ZP 4KAYA 4UOPA 4NWXA 4MIVA 2GA3A 2GSNA 5GRRA 2RH6A 3TWZA 5L0EA 3NKOA 2GLQA 4LRDA 4CYRA 1SHNA 2ANHA 1ZEDA 3IGZB 4UPLA 1K7HA 1SHQA 4N7TA 4UPIA 3NKQA 5EGHA 1AJDA 4LRFA 5IJSA 1ED9A 1EW8A 1AJCA 4YR1A 1ANIA 4NWJA 1E2SP 3IGYB 4KAVA 5EGEA 3B5QA 5GOVA 1EW2A 5L0KA 3DPCA 4LRCA 5KXAA 3SZYA 4UPKA 4LR2A 4MHXA 3WAXA 1ELXA 4LR7A 2IUCA 1KH4A 5C66A 3NKNA 4KJDA 3DYCA 3M7VA 5LQQA 1HJKA 1ZEBA 3NKRA 2W8SA 2W5SA 4MY4A 3TX0A 1ALHA 3WAVA 1ELYA 3A52A 3E2DA 3M8WA 3OT9A 3LXQA 4LRBA 3MK0A 1ALKA 2VQRA 2X98A 1KH9A 4CYSA 4LR9A 1URAA 5LIAA 1ALJA 4KJGA 1B8JA 1KH5A 3ED4A 1N2KA 3KD8A 4KM4A 2W5QA 5DLTA 2IFYA 1N2LA 4ZGAA 1EJJA 1AJAA 4GTZA 1ED8A 5K4PA 3M8ZA 2W8DA 3UN5A 4ZG7A 3T00A 3SZZA 2W5RA 1E33P 1ELZA 4QAXA 5AJ9A 4GTYA 5INHA 1E3CP 3BDHA 2W5XA 3BDFA 3MK2A 4LREA 2W5TA 5HRTA 2D1GA 4LRAA 3UN2A 4CXUA 2ZKTA
chains in the Genus database with same CATH topology
3NKPA 3MK1A 3WBHA 1KHKA 3BDGA 3CMRA 3NVLA 2IUCB 4ZG9A 4CXSA 4LQYA 3T01A 1O99A 2GSUA 4UORA 3UN3A 4ZG6A 1O98A 1P49A 4CXKA 3T02A 2W5WA 3IDDA 5LRNA 1KHJA 4LR8A 1KHLA 3UO0A 2QZUA 3UNYA 4UPHA 5L0BA 4TN0A 3TG0A 1HDHA 5DLVA 1Y7AA 1FSUA 4GTWA 4UOOA 4FDJA 5TJ3A 1Y6VA 1ALIA 3BDGB 3Q3QA 1ANJA 4B56A 2GSOA 5LRMA 3NKMA 1AUKA 3M8YA 4GTXA 2XRGA 1ZEFA 1KHNA 1URBA 5IJQA 2G9YA 2XR9A 1EI6A 3WAWA 5DLWA 1EQJA 1EW9A 1AJBA 3WAYA 2W5VA 1KH7A 1HQAA 4FDIA 1E1ZP 4KAYA 4UOPA 4NWXA 4MIVA 2GA3A 2GSNA 5GRRA 2RH6A 3TWZA 5L0EA 3NKOA 2GLQA 4LRDA 4CYRA 1SHNA 2ANHA 1ZEDA 3IGZB 4UPLA 1K7HA 1SHQA 4N7TA 4UPIA 3NKQA 5EGHA 1AJDA 4LRFA 5IJSA 1ED9A 1EW8A 1AJCA 4YR1A 1ANIA 4NWJA 1E2SP 3IGYB 4KAVA 5EGEA 3B5QA 5GOVA 1EW2A 5L0KA 3DPCA 4LRCA 5KXAA 3SZYA 4UPKA 4LR2A 4MHXA 3WAXA 1ELXA 4LR7A 2IUCA 1KH4A 5C66A 3NKNA 4KJDA 3DYCA 3M7VA 5LQQA 1HJKA 1ZEBA 3NKRA 2W8SA 2W5SA 4MY4A 3TX0A 1ALHA 3WAVA 1ELYA 3A52A 3E2DA 3M8WA 3OT9A 3LXQA 4LRBA 3MK0A 1ALKA 2VQRA 2X98A 1KH9A 4CYSA 4LR9A 1URAA 5LIAA 1ALJA 4KJGA 1B8JA 1KH5A 3ED4A 1N2KA 3KD8A 4KM4A 2W5QA 5DLTA 2IFYA 1N2LA 4ZGAA 1EJJA 1AJAA 4GTZA 1ED8A 5K4PA 3M8ZA 2W8DA 3UN5A 4ZG7A 3T00A 3SZZA 2W5RA 1E33P 1ELZA 4QAXA 5AJ9A 4GTYA 5INHA 1E3CP 3BDHA 2W5XA 3BDFA 3MK2A 4LREA 2W5TA 5HRTA 2D1GA 4LRAA 3UN2A 4CXUA 2ZKTA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3NKP A;  3MK1 A;  3WBH A;  1KHK A;  3BDG A;  3CMR A;  3NVL A;  2IUC B;  4ZG9 A;  4CXS A;  4LQY A;  3T01 A;  1O99 A;  2GSU A;  4UOR A;  3UN3 A;  4ZG6 A;  1O98 A;  1P49 A;  4CXK A;  3T02 A;  2W5W A;  3IDD A;  5LRN A;  1KHJ A;  4LR8 A;  1KHL A;  3UO0 A;  2QZU A;  3UNY A;  4UPH A;  5L0B A;  4TN0 A;  3TG0 A;  1HDH A;  5DLV A;  1Y7A A;  1FSU A;  4GTW A;  4UOO A;  4FDJ A;  5TJ3 A;  1Y6V A;  1ALI A;  3BDG B;  3Q3Q A;  1ANJ A;  4B56 A;  2GSO A;  5LRM A;  3NKM A;  1AUK A;  3M8Y A;  4GTX A;  2XRG A;  1ZEF A;  1KHN A;  1URB A;  5IJQ A;  2G9Y A;  2XR9 A;  1EI6 A;  3WAW A;  5DLW A;  1EQJ A;  1EW9 A;  1AJB A;  3WAY A;  2W5V A;  1KH7 A;  1HQA A;  4FDI A;  1E1Z P;  4KAY A;  4UOP A;  4NWX A;  4MIV A;  2GA3 A;  2GSN A;  5GRR A;  2RH6 A;  3TWZ A;  5L0E A;  3NKO A;  2GLQ A;  4LRD A;  4CYR A;  1SHN A;  2ANH A;  1ZED A;  3IGZ B;  4UPL A;  1K7H A;  1SHQ A;  4N7T A;  4UPI A;  3NKQ A;  5EGH A;  1AJD A;  4LRF A;  5IJS A;  1ED9 A;  1EW8 A;  1AJC A;  4YR1 A;  1ANI A;  4NWJ A;  1E2S P;  3IGY B;  4KAV A;  5EGE A;  3B5Q A;  5GOV A;  1EW2 A;  5L0K A;  3DPC A;  4LRC A;  5KXA A;  3SZY A;  4UPK A;  4LR2 A;  4MHX A;  3WAX A;  1ELX A;  4LR7 A;  2IUC A;  1KH4 A;  5C66 A;  3NKN A;  4KJD A;  3DYC A;  3M7V A;  5LQQ A;  1HJK A;  1ZEB A;  3NKR A;  2W8S A;  2W5S A;  4MY4 A;  3TX0 A;  1ALH A;  3WAV A;  1ELY A;  3A52 A;  3E2D A;  3M8W A;  3OT9 A;  3LXQ A;  4LRB A;  3MK0 A;  1ALK A;  2VQR A;  2X98 A;  1KH9 A;  4CYS A;  4LR9 A;  1URA A;  5LIA A;  1ALJ A;  4KJG A;  1B8J A;  1KH5 A;  3ED4 A;  1N2K A;  3KD8 A;  4KM4 A;  2W5Q A;  5DLT A;  2IFY A;  1N2L A;  4ZGA A;  1EJJ A;  1AJA A;  4GTZ A;  1ED8 A;  5K4P A;  3M8Z A;  2W8D A;  3UN5 A;  4ZG7 A;  3T00 A;  3SZZ A;  2W5R A;  1E33 P;  1ELZ A;  4QAX A;  5AJ9 A;  4GTY A;  5INH A;  1E3C P;  3BDH A;  2W5X A;  3BDF A;  3MK2 A;  4LRE A;  2W5T A;  5HRT A;  2D1G A;  4LRA A;  3UN2 A;  4CXU A;  2ZKT A; 
#chains in the Genus database with same CATH topology
 3NKP A;  3MK1 A;  3WBH A;  1KHK A;  3BDG A;  3CMR A;  3NVL A;  2IUC B;  4ZG9 A;  4CXS A;  4LQY A;  3T01 A;  1O99 A;  2GSU A;  4UOR A;  3UN3 A;  4ZG6 A;  1O98 A;  1P49 A;  4CXK A;  3T02 A;  2W5W A;  3IDD A;  5LRN A;  1KHJ A;  4LR8 A;  1KHL A;  3UO0 A;  2QZU A;  3UNY A;  4UPH A;  5L0B A;  4TN0 A;  3TG0 A;  1HDH A;  5DLV A;  1Y7A A;  1FSU A;  4GTW A;  4UOO A;  4FDJ A;  5TJ3 A;  1Y6V A;  1ALI A;  3BDG B;  3Q3Q A;  1ANJ A;  4B56 A;  2GSO A;  5LRM A;  3NKM A;  1AUK A;  3M8Y A;  4GTX A;  2XRG A;  1ZEF A;  1KHN A;  1URB A;  5IJQ A;  2G9Y A;  2XR9 A;  1EI6 A;  3WAW A;  5DLW A;  1EQJ A;  1EW9 A;  1AJB A;  3WAY A;  2W5V A;  1KH7 A;  1HQA A;  4FDI A;  1E1Z P;  4KAY A;  4UOP A;  4NWX A;  4MIV A;  2GA3 A;  2GSN A;  5GRR A;  2RH6 A;  3TWZ A;  5L0E A;  3NKO A;  2GLQ A;  4LRD A;  4CYR A;  1SHN A;  2ANH A;  1ZED A;  3IGZ B;  4UPL A;  1K7H A;  1SHQ A;  4N7T A;  4UPI A;  3NKQ A;  5EGH A;  1AJD A;  4LRF A;  5IJS A;  1ED9 A;  1EW8 A;  1AJC A;  4YR1 A;  1ANI A;  4NWJ A;  1E2S P;  3IGY B;  4KAV A;  5EGE A;  3B5Q A;  5GOV A;  1EW2 A;  5L0K A;  3DPC A;  4LRC A;  5KXA A;  3SZY A;  4UPK A;  4LR2 A;  4MHX A;  3WAX A;  1ELX A;  4LR7 A;  2IUC A;  1KH4 A;  5C66 A;  3NKN A;  4KJD A;  3DYC A;  3M7V A;  5LQQ A;  1HJK A;  1ZEB A;  3NKR A;  2W8S A;  2W5S A;  4MY4 A;  3TX0 A;  1ALH A;  3WAV A;  1ELY A;  3A52 A;  3E2D A;  3M8W A;  3OT9 A;  3LXQ A;  4LRB A;  3MK0 A;  1ALK A;  2VQR A;  2X98 A;  1KH9 A;  4CYS A;  4LR9 A;  1URA A;  5LIA A;  1ALJ A;  4KJG A;  1B8J A;  1KH5 A;  3ED4 A;  1N2K A;  3KD8 A;  4KM4 A;  2W5Q A;  5DLT A;  2IFY A;  1N2L A;  4ZGA A;  1EJJ A;  1AJA A;  4GTZ A;  1ED8 A;  5K4P A;  3M8Z A;  2W8D A;  3UN5 A;  4ZG7 A;  3T00 A;  3SZZ A;  2W5R A;  1E33 P;  1ELZ A;  4QAX A;  5AJ9 A;  4GTY A;  5INH A;  1E3C P;  3BDH A;  2W5X A;  3BDF A;  3MK2 A;  4LRE A;  2W5T A;  5HRT A;  2D1G A;  4LRA A;  3UN2 A;  4CXU A;  2ZKT A; 
#chains in the Genus database with same CATH homology
 3NKP A;  3MK1 A;  3WBH A;  1KHK A;  3BDG A;  3CMR A;  3NVL A;  2IUC B;  4ZG9 A;  4CXS A;  4LQY A;  3T01 A;  1O99 A;  2GSU A;  4UOR A;  3UN3 A;  4ZG6 A;  1O98 A;  1P49 A;  4CXK A;  3T02 A;  2W5W A;  3IDD A;  5LRN A;  1KHJ A;  4LR8 A;  1KHL A;  3UO0 A;  2QZU A;  3UNY A;  4UPH A;  5L0B A;  4TN0 A;  3TG0 A;  1HDH A;  5DLV A;  1Y7A A;  1FSU A;  4GTW A;  4UOO A;  4FDJ A;  5TJ3 A;  1Y6V A;  1ALI A;  3BDG B;  3Q3Q A;  1ANJ A;  4B56 A;  2GSO A;  5LRM A;  3NKM A;  1AUK A;  3M8Y A;  4GTX A;  2XRG A;  1ZEF A;  1KHN A;  1URB A;  5IJQ A;  2G9Y A;  2XR9 A;  1EI6 A;  3WAW A;  5DLW A;  1EQJ A;  1EW9 A;  1AJB A;  3WAY A;  2W5V A;  1KH7 A;  1HQA A;  4FDI A;  1E1Z P;  4KAY A;  4UOP A;  4NWX A;  4MIV A;  2GA3 A;  2GSN A;  5GRR A;  2RH6 A;  3TWZ A;  5L0E A;  3NKO A;  2GLQ A;  4LRD A;  4CYR A;  1SHN A;  2ANH A;  1ZED A;  3IGZ B;  4UPL A;  1K7H A;  1SHQ A;  4N7T A;  4UPI A;  3NKQ A;  5EGH A;  1AJD A;  4LRF A;  5IJS A;  1ED9 A;  1EW8 A;  1AJC A;  4YR1 A;  1ANI A;  4NWJ A;  1E2S P;  3IGY B;  4KAV A;  5EGE A;  3B5Q A;  5GOV A;  1EW2 A;  5L0K A;  3DPC A;  4LRC A;  5KXA A;  3SZY A;  4UPK A;  4LR2 A;  4MHX A;  3WAX A;  1ELX A;  4LR7 A;  2IUC A;  1KH4 A;  5C66 A;  3NKN A;  4KJD A;  3DYC A;  3M7V A;  5LQQ A;  1HJK A;  1ZEB A;  3NKR A;  2W8S A;  2W5S A;  4MY4 A;  3TX0 A;  1ALH A;  3WAV A;  1ELY A;  3A52 A;  3E2D A;  3M8W A;  3OT9 A;  3LXQ A;  4LRB A;  3MK0 A;  1ALK A;  2VQR A;  2X98 A;  1KH9 A;  4CYS A;  4LR9 A;  1URA A;  5LIA A;  1ALJ A;  4KJG A;  1B8J A;  1KH5 A;  3ED4 A;  1N2K A;  3KD8 A;  4KM4 A;  2W5Q A;  5DLT A;  2IFY A;  1N2L A;  4ZGA A;  1EJJ A;  1AJA A;  4GTZ A;  1ED8 A;  5K4P A;  3M8Z A;  2W8D A;  3UN5 A;  4ZG7 A;  3T00 A;  3SZZ A;  2W5R A;  1E33 P;  1ELZ A;  4QAX A;  5AJ9 A;  4GTY A;  5INH A;  1E3C P;  3BDH A;  2W5X A;  3BDF A;  3MK2 A;  4LRE A;  2W5T A;  5HRT A;  2D1G A;  4LRA A;  3UN2 A;  4CXU A;  2ZKT A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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