1B8JA

Alkaline phosphatase complexed with vanadate
Total Genus 163
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
Knots found
sequence length
449
structure length
448
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PROTEIN (ALKALINE PHOSPHATASE)
publication title A model of the transition state in the alkaline phosphatase reaction.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
total genus 163
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1999-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1b8jA00
4LRBA 5INHA 1AJAA 4UPIA 5EGEA 5LIAA 4CYRA 1ELXA 2W5RA 5HRTA 3TX0A 3DPCA 4KJDA 4LR9A 1N2LA 5DLWA 3WAXA 1KHLA 1ALJA 4CXKA 3NKRA 3A52A 5L0EA 2QZUA 2RH6A 3MK1A 5GRRA 1ED8A 2G9YA 4MY4A 3UN5A 3NVLA 1ED9A 1ANJA 1EQJA 3M8YA 1ZEDA 2GSNA 3CMRA 4FDJA 3T01A 2XRGA 4ZG6A 4CYSA 3TG0A 2IFYA 4UORA 5LQQA 3DYCA 5IJQA 1HQAA 4LRAA 4UOPA 3NKNA 1URAA 2D1GA 2ZKTA 3WAYA 2IUCB 4N7TA 4UPKA 1O98A 4KAYA 4KAVA 2XR9A 1URBA 3BDFA 3LXQA 5DLTA 1EI6A 3UNYA 1K7HA 1KHNA 3Q3QA 3NKOA 3SZZA 4CXUA 4QAXA 2GSOA 2W5QA 4UPLA 3T02A 3E2DA 5IJSA 1AJDA 3M8WA 5L0BA 1E3CP 1KHJA 5K4PA 3BDGA 4MHXA 1O99A 1SHQA 3IDDA 3TWZA 3WAVA 5DLVA 3M7VA 4TN0A 3M8ZA 1Y7AA 5TJ3A 2GLQA 3SZYA 4LR8A 4LREA 3WAWA 3ED4A 3B5QA 1KH7A 2W5SA 1KHKA 5KXAA 4LQYA 5LRNA 1ZEFA 1E2SP 1EW2A 4ZG9A 1ELZA 2W8DA 2ANHA 1N2KA 3UN2A 3BDGB 4GTWA 4MIVA 1AUKA 4GTZA 3MK0A 4LRFA 4YR1A 5AJ9A 1ALIA 4B56A 3NKPA 5LRMA 4LR7A 1KH4A 2W5XA 3NKQA 1E33P 4ZGAA 5L0KA 3NKMA 2GA3A 5EGHA 4NWXA 3T00A 1KH9A 4UOOA 4LRDA 1ANIA 1ALHA 2X98A 4KJGA 3OT9A 1SHNA 1ZEBA 1P49A 5GOVA 1AJBA 2GSUA 2W5TA 1KH5A 3BDHA 1HJKA 3UO0A 5C66A 4CXSA 4UPHA 3MK2A 4LR2A 2W8SA 4GTYA 2IUCA 4NWJA 4LRCA 1HDHA 3IGZB 3WBHA 1FSUA 1EW9A 1ELYA 1AJCA 4KM4A 1EJJA 3UN3A 1EW8A 1ALKA 1B8JA 2VQRA 3IGYB 1E1ZP 4GTXA 4FDIA 4ZG7A 2W5VA 1Y6VA 2W5WA 3KD8A
chains in the Genus database with same CATH superfamily
4LRBA 5INHA 1AJAA 4UPIA 5EGEA 5LIAA 4CYRA 1ELXA 2W5RA 5HRTA 3TX0A 3DPCA 4KJDA 4LR9A 1N2LA 5DLWA 3WAXA 1KHLA 1ALJA 4CXKA 3NKRA 3A52A 5L0EA 2QZUA 2RH6A 3MK1A 5GRRA 1ED8A 2G9YA 4MY4A 3UN5A 3NVLA 1ED9A 1ANJA 1EQJA 3M8YA 1ZEDA 2GSNA 3CMRA 4FDJA 3T01A 2XRGA 4ZG6A 4CYSA 3TG0A 2IFYA 4UORA 5LQQA 3DYCA 5IJQA 1HQAA 4LRAA 4UOPA 3NKNA 1URAA 2D1GA 2ZKTA 3WAYA 2IUCB 4N7TA 4UPKA 1O98A 4KAYA 4KAVA 2XR9A 1URBA 3BDFA 3LXQA 5DLTA 1EI6A 3UNYA 1K7HA 1KHNA 3Q3QA 3NKOA 3SZZA 4CXUA 4QAXA 2GSOA 2W5QA 4UPLA 3T02A 3E2DA 5IJSA 1AJDA 3M8WA 5L0BA 1E3CP 1KHJA 5K4PA 3BDGA 4MHXA 1O99A 1SHQA 3IDDA 3TWZA 3WAVA 5DLVA 3M7VA 4TN0A 3M8ZA 1Y7AA 5TJ3A 2GLQA 3SZYA 4LR8A 4LREA 3WAWA 3ED4A 3B5QA 1KH7A 2W5SA 1KHKA 5KXAA 4LQYA 5LRNA 1ZEFA 1E2SP 1EW2A 4ZG9A 1ELZA 2W8DA 2ANHA 1N2KA 3UN2A 3BDGB 4GTWA 4MIVA 1AUKA 4GTZA 3MK0A 4LRFA 4YR1A 5AJ9A 1ALIA 4B56A 3NKPA 5LRMA 4LR7A 1KH4A 2W5XA 3NKQA 1E33P 4ZGAA 5L0KA 3NKMA 2GA3A 5EGHA 4NWXA 3T00A 1KH9A 4UOOA 4LRDA 1ANIA 1ALHA 2X98A 4KJGA 3OT9A 1SHNA 1ZEBA 1P49A 5GOVA 1AJBA 2GSUA 2W5TA 1KH5A 3BDHA 1HJKA 3UO0A 5C66A 4CXSA 4UPHA 3MK2A 4LR2A 2W8SA 4GTYA 2IUCA 4NWJA 4LRCA 1HDHA 3IGZB 3WBHA 1FSUA 1EW9A 1ELYA 1AJCA 4KM4A 1EJJA 3UN3A 1EW8A 1ALKA 1B8JA 2VQRA 3IGYB 1E1ZP 4GTXA 4FDIA 4ZG7A 2W5VA 1Y6VA 2W5WA 3KD8A
chains in the Genus database with same CATH topology
4LRBA 5INHA 1AJAA 4UPIA 5EGEA 5LIAA 4CYRA 1ELXA 2W5RA 5HRTA 3TX0A 3DPCA 4KJDA 4LR9A 1N2LA 5DLWA 3WAXA 1KHLA 1ALJA 4CXKA 3NKRA 3A52A 5L0EA 2QZUA 2RH6A 3MK1A 5GRRA 1ED8A 2G9YA 4MY4A 3UN5A 3NVLA 1ED9A 1ANJA 1EQJA 3M8YA 1ZEDA 2GSNA 3CMRA 4FDJA 3T01A 2XRGA 4ZG6A 4CYSA 3TG0A 2IFYA 4UORA 5LQQA 3DYCA 5IJQA 1HQAA 4LRAA 4UOPA 3NKNA 1URAA 2D1GA 2ZKTA 3WAYA 2IUCB 4N7TA 4UPKA 1O98A 4KAYA 4KAVA 2XR9A 1URBA 3BDFA 3LXQA 5DLTA 1EI6A 3UNYA 1K7HA 1KHNA 3Q3QA 3NKOA 3SZZA 4CXUA 4QAXA 2GSOA 2W5QA 4UPLA 3T02A 3E2DA 5IJSA 1AJDA 3M8WA 5L0BA 1E3CP 1KHJA 5K4PA 3BDGA 4MHXA 1O99A 1SHQA 3IDDA 3TWZA 3WAVA 5DLVA 3M7VA 4TN0A 3M8ZA 1Y7AA 5TJ3A 2GLQA 3SZYA 4LR8A 4LREA 3WAWA 3ED4A 3B5QA 1KH7A 2W5SA 1KHKA 5KXAA 4LQYA 5LRNA 1ZEFA 1E2SP 1EW2A 4ZG9A 1ELZA 2W8DA 2ANHA 1N2KA 3UN2A 3BDGB 4GTWA 4MIVA 1AUKA 4GTZA 3MK0A 4LRFA 4YR1A 5AJ9A 1ALIA 4B56A 3NKPA 5LRMA 4LR7A 1KH4A 2W5XA 3NKQA 1E33P 4ZGAA 5L0KA 3NKMA 2GA3A 5EGHA 4NWXA 3T00A 1KH9A 4UOOA 4LRDA 1ANIA 1ALHA 2X98A 4KJGA 3OT9A 1SHNA 1ZEBA 1P49A 5GOVA 1AJBA 2GSUA 2W5TA 1KH5A 3BDHA 1HJKA 3UO0A 5C66A 4CXSA 4UPHA 3MK2A 4LR2A 2W8SA 4GTYA 2IUCA 4NWJA 4LRCA 1HDHA 3IGZB 3WBHA 1FSUA 1EW9A 1ELYA 1AJCA 4KM4A 1EJJA 3UN3A 1EW8A 1ALKA 1B8JA 2VQRA 3IGYB 1E1ZP 4GTXA 4FDIA 4ZG7A 2W5VA 1Y6VA 2W5WA 3KD8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LRB A;  5INH A;  1AJA A;  4UPI A;  5EGE A;  5LIA A;  4CYR A;  1ELX A;  2W5R A;  5HRT A;  3TX0 A;  3DPC A;  4KJD A;  4LR9 A;  1N2L A;  5DLW A;  3WAX A;  1KHL A;  1ALJ A;  4CXK A;  3NKR A;  3A52 A;  5L0E A;  2QZU A;  2RH6 A;  3MK1 A;  5GRR A;  1ED8 A;  2G9Y A;  4MY4 A;  3UN5 A;  3NVL A;  1ED9 A;  1ANJ A;  1EQJ A;  3M8Y A;  1ZED A;  2GSN A;  3CMR A;  4FDJ A;  3T01 A;  2XRG A;  4ZG6 A;  4CYS A;  3TG0 A;  2IFY A;  4UOR A;  5LQQ A;  3DYC A;  5IJQ A;  1HQA A;  4LRA A;  4UOP A;  3NKN A;  1URA A;  2D1G A;  2ZKT A;  3WAY A;  2IUC B;  4N7T A;  4UPK A;  1O98 A;  4KAY A;  4KAV A;  2XR9 A;  1URB A;  3BDF A;  3LXQ A;  5DLT A;  1EI6 A;  3UNY A;  1K7H A;  1KHN A;  3Q3Q A;  3NKO A;  3SZZ A;  4CXU A;  4QAX A;  2GSO A;  2W5Q A;  4UPL A;  3T02 A;  3E2D A;  5IJS A;  1AJD A;  3M8W A;  5L0B A;  1E3C P;  1KHJ A;  5K4P A;  3BDG A;  4MHX A;  1O99 A;  1SHQ A;  3IDD A;  3TWZ A;  3WAV A;  5DLV A;  3M7V A;  4TN0 A;  3M8Z A;  1Y7A A;  5TJ3 A;  2GLQ A;  3SZY A;  4LR8 A;  4LRE A;  3WAW A;  3ED4 A;  3B5Q A;  1KH7 A;  2W5S A;  1KHK A;  5KXA A;  4LQY A;  5LRN A;  1ZEF A;  1E2S P;  1EW2 A;  4ZG9 A;  1ELZ A;  2W8D A;  2ANH A;  1N2K A;  3UN2 A;  3BDG B;  4GTW A;  4MIV A;  1AUK A;  4GTZ A;  3MK0 A;  4LRF A;  4YR1 A;  5AJ9 A;  1ALI A;  4B56 A;  3NKP A;  5LRM A;  4LR7 A;  1KH4 A;  2W5X A;  3NKQ A;  1E33 P;  4ZGA A;  5L0K A;  3NKM A;  2GA3 A;  5EGH A;  4NWX A;  3T00 A;  1KH9 A;  4UOO A;  4LRD A;  1ANI A;  1ALH A;  2X98 A;  4KJG A;  3OT9 A;  1SHN A;  1ZEB A;  1P49 A;  5GOV A;  1AJB A;  2GSU A;  2W5T A;  1KH5 A;  3BDH A;  1HJK A;  3UO0 A;  5C66 A;  4CXS A;  4UPH A;  3MK2 A;  4LR2 A;  2W8S A;  4GTY A;  2IUC A;  4NWJ A;  4LRC A;  1HDH A;  3IGZ B;  3WBH A;  1FSU A;  1EW9 A;  1ELY A;  1AJC A;  4KM4 A;  1EJJ A;  3UN3 A;  1EW8 A;  1ALK A;  1B8J A;  2VQR A;  3IGY B;  1E1Z P;  4GTX A;  4FDI A;  4ZG7 A;  2W5V A;  1Y6V A;  2W5W A;  3KD8 A; 
#chains in the Genus database with same CATH topology
 4LRB A;  5INH A;  1AJA A;  4UPI A;  5EGE A;  5LIA A;  4CYR A;  1ELX A;  2W5R A;  5HRT A;  3TX0 A;  3DPC A;  4KJD A;  4LR9 A;  1N2L A;  5DLW A;  3WAX A;  1KHL A;  1ALJ A;  4CXK A;  3NKR A;  3A52 A;  5L0E A;  2QZU A;  2RH6 A;  3MK1 A;  5GRR A;  1ED8 A;  2G9Y A;  4MY4 A;  3UN5 A;  3NVL A;  1ED9 A;  1ANJ A;  1EQJ A;  3M8Y A;  1ZED A;  2GSN A;  3CMR A;  4FDJ A;  3T01 A;  2XRG A;  4ZG6 A;  4CYS A;  3TG0 A;  2IFY A;  4UOR A;  5LQQ A;  3DYC A;  5IJQ A;  1HQA A;  4LRA A;  4UOP A;  3NKN A;  1URA A;  2D1G A;  2ZKT A;  3WAY A;  2IUC B;  4N7T A;  4UPK A;  1O98 A;  4KAY A;  4KAV A;  2XR9 A;  1URB A;  3BDF A;  3LXQ A;  5DLT A;  1EI6 A;  3UNY A;  1K7H A;  1KHN A;  3Q3Q A;  3NKO A;  3SZZ A;  4CXU A;  4QAX A;  2GSO A;  2W5Q A;  4UPL A;  3T02 A;  3E2D A;  5IJS A;  1AJD A;  3M8W A;  5L0B A;  1E3C P;  1KHJ A;  5K4P A;  3BDG A;  4MHX A;  1O99 A;  1SHQ A;  3IDD A;  3TWZ A;  3WAV A;  5DLV A;  3M7V A;  4TN0 A;  3M8Z A;  1Y7A A;  5TJ3 A;  2GLQ A;  3SZY A;  4LR8 A;  4LRE A;  3WAW A;  3ED4 A;  3B5Q A;  1KH7 A;  2W5S A;  1KHK A;  5KXA A;  4LQY A;  5LRN A;  1ZEF A;  1E2S P;  1EW2 A;  4ZG9 A;  1ELZ A;  2W8D A;  2ANH A;  1N2K A;  3UN2 A;  3BDG B;  4GTW A;  4MIV A;  1AUK A;  4GTZ A;  3MK0 A;  4LRF A;  4YR1 A;  5AJ9 A;  1ALI A;  4B56 A;  3NKP A;  5LRM A;  4LR7 A;  1KH4 A;  2W5X A;  3NKQ A;  1E33 P;  4ZGA A;  5L0K A;  3NKM A;  2GA3 A;  5EGH A;  4NWX A;  3T00 A;  1KH9 A;  4UOO A;  4LRD A;  1ANI A;  1ALH A;  2X98 A;  4KJG A;  3OT9 A;  1SHN A;  1ZEB A;  1P49 A;  5GOV A;  1AJB A;  2GSU A;  2W5T A;  1KH5 A;  3BDH A;  1HJK A;  3UO0 A;  5C66 A;  4CXS A;  4UPH A;  3MK2 A;  4LR2 A;  2W8S A;  4GTY A;  2IUC A;  4NWJ A;  4LRC A;  1HDH A;  3IGZ B;  3WBH A;  1FSU A;  1EW9 A;  1ELY A;  1AJC A;  4KM4 A;  1EJJ A;  3UN3 A;  1EW8 A;  1ALK A;  1B8J A;  2VQR A;  3IGY B;  1E1Z P;  4GTX A;  4FDI A;  4ZG7 A;  2W5V A;  1Y6V A;  2W5W A;  3KD8 A; 
#chains in the Genus database with same CATH homology
 4LRB A;  5INH A;  1AJA A;  4UPI A;  5EGE A;  5LIA A;  4CYR A;  1ELX A;  2W5R A;  5HRT A;  3TX0 A;  3DPC A;  4KJD A;  4LR9 A;  1N2L A;  5DLW A;  3WAX A;  1KHL A;  1ALJ A;  4CXK A;  3NKR A;  3A52 A;  5L0E A;  2QZU A;  2RH6 A;  3MK1 A;  5GRR A;  1ED8 A;  2G9Y A;  4MY4 A;  3UN5 A;  3NVL A;  1ED9 A;  1ANJ A;  1EQJ A;  3M8Y A;  1ZED A;  2GSN A;  3CMR A;  4FDJ A;  3T01 A;  2XRG A;  4ZG6 A;  4CYS A;  3TG0 A;  2IFY A;  4UOR A;  5LQQ A;  3DYC A;  5IJQ A;  1HQA A;  4LRA A;  4UOP A;  3NKN A;  1URA A;  2D1G A;  2ZKT A;  3WAY A;  2IUC B;  4N7T A;  4UPK A;  1O98 A;  4KAY A;  4KAV A;  2XR9 A;  1URB A;  3BDF A;  3LXQ A;  5DLT A;  1EI6 A;  3UNY A;  1K7H A;  1KHN A;  3Q3Q A;  3NKO A;  3SZZ A;  4CXU A;  4QAX A;  2GSO A;  2W5Q A;  4UPL A;  3T02 A;  3E2D A;  5IJS A;  1AJD A;  3M8W A;  5L0B A;  1E3C P;  1KHJ A;  5K4P A;  3BDG A;  4MHX A;  1O99 A;  1SHQ A;  3IDD A;  3TWZ A;  3WAV A;  5DLV A;  3M7V A;  4TN0 A;  3M8Z A;  1Y7A A;  5TJ3 A;  2GLQ A;  3SZY A;  4LR8 A;  4LRE A;  3WAW A;  3ED4 A;  3B5Q A;  1KH7 A;  2W5S A;  1KHK A;  5KXA A;  4LQY A;  5LRN A;  1ZEF A;  1E2S P;  1EW2 A;  4ZG9 A;  1ELZ A;  2W8D A;  2ANH A;  1N2K A;  3UN2 A;  3BDG B;  4GTW A;  4MIV A;  1AUK A;  4GTZ A;  3MK0 A;  4LRF A;  4YR1 A;  5AJ9 A;  1ALI A;  4B56 A;  3NKP A;  5LRM A;  4LR7 A;  1KH4 A;  2W5X A;  3NKQ A;  1E33 P;  4ZGA A;  5L0K A;  3NKM A;  2GA3 A;  5EGH A;  4NWX A;  3T00 A;  1KH9 A;  4UOO A;  4LRD A;  1ANI A;  1ALH A;  2X98 A;  4KJG A;  3OT9 A;  1SHN A;  1ZEB A;  1P49 A;  5GOV A;  1AJB A;  2GSU A;  2W5T A;  1KH5 A;  3BDH A;  1HJK A;  3UO0 A;  5C66 A;  4CXS A;  4UPH A;  3MK2 A;  4LR2 A;  2W8S A;  4GTY A;  2IUC A;  4NWJ A;  4LRC A;  1HDH A;  3IGZ B;  3WBH A;  1FSU A;  1EW9 A;  1ELY A;  1AJC A;  4KM4 A;  1EJJ A;  3UN3 A;  1EW8 A;  1ALK A;  1B8J A;  2VQR A;  3IGY B;  1E1Z P;  4GTX A;  4FDI A;  4ZG7 A;  2W5V A;  1Y6V A;  2W5W A;  3KD8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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