1C21A

E. coli methionine aminopeptidase: methionine complex
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
pubmed doi rcsb
molecule keywords METHIONINE AMINOPEPTIDASE
molecule tags Hydrolase
source organism Escherichia coli
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 1999-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1c21A00
2GA2A 3BIPA 4FLJA 2GG3A 1R5GA 2GU4A 1Y1NA 1C27A 3BIQA 2V3XA 1R5HA 1CHMA 1WN1A 1XGSA 3PKEA 5CDVA 4ZWOA 1MATA 1N51A 1WL9A 1XGNA 4IF7A 3RVAA 1W7VA 3BITA 2BHBA 5E5BA 2GG2A 4PV4A 2Q92A 2BH3A 5CLSA 3CTZA 1YVMA 4RGZ1 1YJ3A 4FLLA 1R58A 1BOAA 4Z7MA 1QXYA 2P99A 1WKMA 4U1BA 2P98A 1KQ0A 4FKCA 4S01A 2BWTA 2GG8A 1BN5A 2Q94A 2BWSA 4RZYA 1YW9A 2GU6A 4IU6A 1QXZA 2Q93A 1C22A 1C24A 3CB6A 2DFIA 1YW7A 4OOKA 5D6FA 3MATA 2Q8KA 3MX6A 2V6CA 2OAZA 1XGOA 2NQ6A 2GG9A 4S00A 2BHCA 2GG0A 3L24A 4S2RP 3IU7A 4FUKA 4U6WA 2BWVA 2BHDA 3FM3A 1XGMA 4MATA 3S6BA 4IKTA 1KQ9A 4KM3A 4ZNGA 3PKCA 2EA2A 2GZ5A 1WL6A 2BWUA 4FO7A 2EVCA 4FLKA 5CNXA 2EVMA 5FCHA 5CDEA 4U6CA 2NQ7A 4IDYA 3RORA 2EVOA 2GGBA 1A16A 1M35A 2V3ZA 4A6WA 4EGEA 3L7GA 2V3YA 3IG4A 1B59A 4S2TP 2BWWA 2B3HA 4FLIA 2GU5A 2Q96A 1QXWA 1WLRA 5JHUA 2B3LA 2BN7A 2GG5A 4RZZA 1W2MA 2ZSGA 4IECA 4B28A 1XNZA 2GTXA 1C23A 2ADUA 1KP0A 3MR1A 3PKDA 4U69A 2BHAA 2BB7A 5D6EA 4A6VA 4R60A 3TAVA 3TB5A 2IW2A 5FCFA 4U75A 1JAWA 4ZWPA 3FMQA 1YW8A 4U76A 4ZWUA 4IKSA 4U6EA 2B3KA 4U6JA 4PNCA 4U73A 3PKAA 4QR8A 1B6AA 5JFRA 2Q95A 4U70A 1O0XA 3IU9A 4U71A 4IPAA 3Q6DA 2G6PA 2MATA 2P9AA 5CDLA 2HOWA 4IKRA 5JI6A 4HXXA 2EA4A 1C21A 4IKUA 5CE6A 1PV9A 1WY2A 2GGCA 1QZYA 3CB5A 3PKBA 3FMRA 4U6ZA 2GG7A 5CIKA 1WBQA 2GU7A 2OKNA 3IU8A 4FO8A 3D27A 4JUQA 2BWYA 2BWXA
chains in the Genus database with same CATH superfamily
2GA2A 3BIPA 4FLJA 2GG3A 1R5GA 2GU4A 1Y1NA 1C27A 3BIQA 2V3XA 1R5HA 1CHMA 1WN1A 1XGSA 3PKEA 5CDVA 4ZWOA 1MATA 1N51A 1WL9A 1XGNA 4IF7A 3RVAA 1W7VA 3BITA 2BHBA 5E5BA 2GG2A 4PV4A 2Q92A 2BH3A 5CLSA 3CTZA 1YVMA 4RGZ1 1YJ3A 4FLLA 1R58A 1BOAA 4Z7MA 1QXYA 2P99A 1WKMA 4U1BA 2P98A 1KQ0A 4FKCA 4S01A 2BWTA 2GG8A 1BN5A 2Q94A 2BWSA 4RZYA 1YW9A 2GU6A 4IU6A 1QXZA 2Q93A 1C22A 1C24A 3CB6A 2DFIA 1YW7A 4OOKA 5D6FA 3MATA 2Q8KA 3MX6A 2V6CA 2OAZA 1XGOA 2NQ6A 2GG9A 4S00A 2BHCA 2GG0A 3L24A 4S2RP 3IU7A 4FUKA 4U6WA 2BWVA 2BHDA 3FM3A 1XGMA 4MATA 3S6BA 4IKTA 1KQ9A 4KM3A 4ZNGA 3PKCA 2EA2A 2GZ5A 1WL6A 2BWUA 4FO7A 2EVCA 4FLKA 5CNXA 2EVMA 5FCHA 5CDEA 4U6CA 2NQ7A 4IDYA 3RORA 2EVOA 2GGBA 1A16A 1M35A 2V3ZA 4A6WA 4EGEA 3L7GA 2V3YA 3IG4A 1B59A 4S2TP 2BWWA 2B3HA 4FLIA 2GU5A 2Q96A 1QXWA 1WLRA 5JHUA 2B3LA 2BN7A 2GG5A 4RZZA 1W2MA 2ZSGA 4IECA 4B28A 1XNZA 2GTXA 1C23A 2ADUA 1KP0A 3MR1A 3PKDA 4U69A 2BHAA 2BB7A 5D6EA 4A6VA 4R60A 3TAVA 3TB5A 2IW2A 5FCFA 4U75A 1JAWA 4ZWPA 3FMQA 1YW8A 4U76A 4ZWUA 4IKSA 4U6EA 2B3KA 4U6JA 4PNCA 4U73A 3PKAA 4QR8A 1B6AA 5JFRA 2Q95A 4U70A 1O0XA 3IU9A 4U71A 4IPAA 3Q6DA 2G6PA 2MATA 2P9AA 5CDLA 2HOWA 4IKRA 5JI6A 4HXXA 2EA4A 1C21A 4IKUA 5CE6A 1PV9A 1WY2A 2GGCA 1QZYA 3CB5A 3PKBA 3FMRA 4U6ZA 2GG7A 5CIKA 1WBQA 2GU7A 2OKNA 3IU8A 4FO8A 3D27A 4JUQA 2BWYA 2BWXA
chains in the Genus database with same CATH topology
2GA2A 3BIPA 4FLJA 2GG3A 1R5GA 2GU4A 1Y1NA 1C27A 3BIQA 2V3XA 1R5HA 1CHMA 1WN1A 1XGSA 3PKEA 5CDVA 4ZWOA 1MATA 1N51A 1WL9A 1XGNA 4IF7A 3RVAA 1W7VA 3BITA 2BHBA 5E5BA 2GG2A 4PV4A 2Q92A 2BH3A 5CLSA 3CTZA 1YVMA 4RGZ1 1YJ3A 4FLLA 1R58A 1BOAA 4Z7MA 1QXYA 2P99A 1WKMA 4U1BA 2P98A 1KQ0A 4FKCA 4S01A 2BWTA 2GG8A 1BN5A 2Q94A 2BWSA 4RZYA 1YW9A 2GU6A 4IU6A 1QXZA 2Q93A 1C22A 1C24A 3CB6A 2DFIA 1YW7A 4OOKA 5D6FA 3MATA 2Q8KA 3MX6A 2V6CA 2OAZA 1XGOA 2NQ6A 2GG9A 4S00A 2BHCA 2GG0A 3L24A 4S2RP 3IU7A 4FUKA 4U6WA 2BWVA 2BHDA 3FM3A 1XGMA 4MATA 3S6BA 4IKTA 1KQ9A 4KM3A 4ZNGA 3PKCA 2EA2A 2GZ5A 1WL6A 2BWUA 4FO7A 2EVCA 4FLKA 5CNXA 2EVMA 5FCHA 5CDEA 4U6CA 2NQ7A 4IDYA 3RORA 2EVOA 2GGBA 1A16A 1M35A 2V3ZA 4A6WA 4EGEA 3L7GA 2V3YA 3IG4A 1B59A 4S2TP 2BWWA 2B3HA 4FLIA 2GU5A 2Q96A 1QXWA 1WLRA 5JHUA 2B3LA 2BN7A 2GG5A 4RZZA 1W2MA 2ZSGA 4IECA 4B28A 1XNZA 2GTXA 1C23A 2ADUA 1KP0A 3MR1A 3PKDA 4U69A 2BHAA 2BB7A 5D6EA 4A6VA 4R60A 3TAVA 3TB5A 2IW2A 5FCFA 4U75A 1JAWA 4ZWPA 3FMQA 1YW8A 4U76A 4ZWUA 4IKSA 4U6EA 2B3KA 4U6JA 4PNCA 4U73A 3PKAA 4QR8A 1B6AA 5JFRA 2Q95A 4U70A 1O0XA 3IU9A 4U71A 4IPAA 3Q6DA 2G6PA 2MATA 2P9AA 5CDLA 2HOWA 4IKRA 5JI6A 4HXXA 2EA4A 1C21A 4IKUA 5CE6A 1PV9A 1WY2A 2GGCA 1QZYA 3CB5A 3PKBA 3FMRA 4U6ZA 2GG7A 5CIKA 1WBQA 2GU7A 2OKNA 3IU8A 4FO8A 3D27A 4JUQA 2BWYA 2BWXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GA2 A;  3BIP A;  4FLJ A;  2GG3 A;  1R5G A;  2GU4 A;  1Y1N A;  1C27 A;  3BIQ A;  2V3X A;  1R5H A;  1CHM A;  1WN1 A;  1XGS A;  3PKE A;  5CDV A;  4ZWO A;  1MAT A;  1N51 A;  1WL9 A;  1XGN A;  4IF7 A;  3RVA A;  1W7V A;  3BIT A;  2BHB A;  5E5B A;  2GG2 A;  4PV4 A;  2Q92 A;  2BH3 A;  5CLS A;  3CTZ A;  1YVM A;  4RGZ 1;  1YJ3 A;  4FLL A;  1R58 A;  1BOA A;  4Z7M A;  1QXY A;  2P99 A;  1WKM A;  4U1B A;  2P98 A;  1KQ0 A;  4FKC A;  4S01 A;  2BWT A;  2GG8 A;  1BN5 A;  2Q94 A;  2BWS A;  4RZY A;  1YW9 A;  2GU6 A;  4IU6 A;  1QXZ A;  2Q93 A;  1C22 A;  1C24 A;  3CB6 A;  2DFI A;  1YW7 A;  4OOK A;  5D6F A;  3MAT A;  2Q8K A;  3MX6 A;  2V6C A;  2OAZ A;  1XGO A;  2NQ6 A;  2GG9 A;  4S00 A;  2BHC A;  2GG0 A;  3L24 A;  4S2R P;  3IU7 A;  4FUK A;  4U6W A;  2BWV A;  2BHD A;  3FM3 A;  1XGM A;  4MAT A;  3S6B A;  4IKT A;  1KQ9 A;  4KM3 A;  4ZNG A;  3PKC A;  2EA2 A;  2GZ5 A;  1WL6 A;  2BWU A;  4FO7 A;  2EVC A;  4FLK A;  5CNX A;  2EVM A;  5FCH A;  5CDE A;  4U6C A;  2NQ7 A;  4IDY A;  3ROR A;  2EVO A;  2GGB A;  1A16 A;  1M35 A;  2V3Z A;  4A6W A;  4EGE A;  3L7G A;  2V3Y A;  3IG4 A;  1B59 A;  4S2T P;  2BWW A;  2B3H A;  4FLI A;  2GU5 A;  2Q96 A;  1QXW A;  1WLR A;  5JHU A;  2B3L A;  2BN7 A;  2GG5 A;  4RZZ A;  1W2M A;  2ZSG A;  4IEC A;  4B28 A;  1XNZ A;  2GTX A;  1C23 A;  2ADU A;  1KP0 A;  3MR1 A;  3PKD A;  4U69 A;  2BHA A;  2BB7 A;  5D6E A;  4A6V A;  4R60 A;  3TAV A;  3TB5 A;  2IW2 A;  5FCF A;  4U75 A;  1JAW A;  4ZWP A;  3FMQ A;  1YW8 A;  4U76 A;  4ZWU A;  4IKS A;  4U6E A;  2B3K A;  4U6J A;  4PNC A;  4U73 A;  3PKA A;  4QR8 A;  1B6A A;  5JFR A;  2Q95 A;  4U70 A;  1O0X A;  3IU9 A;  4U71 A;  4IPA A;  3Q6D A;  2G6P A;  2MAT A;  2P9A A;  5CDL A;  2HOW A;  4IKR A;  5JI6 A;  4HXX A;  2EA4 A;  1C21 A;  4IKU A;  5CE6 A;  1PV9 A;  1WY2 A;  2GGC A;  1QZY A;  3CB5 A;  3PKB A;  3FMR A;  4U6Z A;  2GG7 A;  5CIK A;  1WBQ A;  2GU7 A;  2OKN A;  3IU8 A;  4FO8 A;  3D27 A;  4JUQ A;  2BWY A;  2BWX A; 
#chains in the Genus database with same CATH topology
 2GA2 A;  3BIP A;  4FLJ A;  2GG3 A;  1R5G A;  2GU4 A;  1Y1N A;  1C27 A;  3BIQ A;  2V3X A;  1R5H A;  1CHM A;  1WN1 A;  1XGS A;  3PKE A;  5CDV A;  4ZWO A;  1MAT A;  1N51 A;  1WL9 A;  1XGN A;  4IF7 A;  3RVA A;  1W7V A;  3BIT A;  2BHB A;  5E5B A;  2GG2 A;  4PV4 A;  2Q92 A;  2BH3 A;  5CLS A;  3CTZ A;  1YVM A;  4RGZ 1;  1YJ3 A;  4FLL A;  1R58 A;  1BOA A;  4Z7M A;  1QXY A;  2P99 A;  1WKM A;  4U1B A;  2P98 A;  1KQ0 A;  4FKC A;  4S01 A;  2BWT A;  2GG8 A;  1BN5 A;  2Q94 A;  2BWS A;  4RZY A;  1YW9 A;  2GU6 A;  4IU6 A;  1QXZ A;  2Q93 A;  1C22 A;  1C24 A;  3CB6 A;  2DFI A;  1YW7 A;  4OOK A;  5D6F A;  3MAT A;  2Q8K A;  3MX6 A;  2V6C A;  2OAZ A;  1XGO A;  2NQ6 A;  2GG9 A;  4S00 A;  2BHC A;  2GG0 A;  3L24 A;  4S2R P;  3IU7 A;  4FUK A;  4U6W A;  2BWV A;  2BHD A;  3FM3 A;  1XGM A;  4MAT A;  3S6B A;  4IKT A;  1KQ9 A;  4KM3 A;  4ZNG A;  3PKC A;  2EA2 A;  2GZ5 A;  1WL6 A;  2BWU A;  4FO7 A;  2EVC A;  4FLK A;  5CNX A;  2EVM A;  5FCH A;  5CDE A;  4U6C A;  2NQ7 A;  4IDY A;  3ROR A;  2EVO A;  2GGB A;  1A16 A;  1M35 A;  2V3Z A;  4A6W A;  4EGE A;  3L7G A;  2V3Y A;  3IG4 A;  1B59 A;  4S2T P;  2BWW A;  2B3H A;  4FLI A;  2GU5 A;  2Q96 A;  1QXW A;  1WLR A;  5JHU A;  2B3L A;  2BN7 A;  2GG5 A;  4RZZ A;  1W2M A;  2ZSG A;  4IEC A;  4B28 A;  1XNZ A;  2GTX A;  1C23 A;  2ADU A;  1KP0 A;  3MR1 A;  3PKD A;  4U69 A;  2BHA A;  2BB7 A;  5D6E A;  4A6V A;  4R60 A;  3TAV A;  3TB5 A;  2IW2 A;  5FCF A;  4U75 A;  1JAW A;  4ZWP A;  3FMQ A;  1YW8 A;  4U76 A;  4ZWU A;  4IKS A;  4U6E A;  2B3K A;  4U6J A;  4PNC A;  4U73 A;  3PKA A;  4QR8 A;  1B6A A;  5JFR A;  2Q95 A;  4U70 A;  1O0X A;  3IU9 A;  4U71 A;  4IPA A;  3Q6D A;  2G6P A;  2MAT A;  2P9A A;  5CDL A;  2HOW A;  4IKR A;  5JI6 A;  4HXX A;  2EA4 A;  1C21 A;  4IKU A;  5CE6 A;  1PV9 A;  1WY2 A;  2GGC A;  1QZY A;  3CB5 A;  3PKB A;  3FMR A;  4U6Z A;  2GG7 A;  5CIK A;  1WBQ A;  2GU7 A;  2OKN A;  3IU8 A;  4FO8 A;  3D27 A;  4JUQ A;  2BWY A;  2BWX A; 
#chains in the Genus database with same CATH homology
 2GA2 A;  3BIP A;  4FLJ A;  2GG3 A;  1R5G A;  2GU4 A;  1Y1N A;  1C27 A;  3BIQ A;  2V3X A;  1R5H A;  1CHM A;  1WN1 A;  1XGS A;  3PKE A;  5CDV A;  4ZWO A;  1MAT A;  1N51 A;  1WL9 A;  1XGN A;  4IF7 A;  3RVA A;  1W7V A;  3BIT A;  2BHB A;  5E5B A;  2GG2 A;  4PV4 A;  2Q92 A;  2BH3 A;  5CLS A;  3CTZ A;  1YVM A;  4RGZ 1;  1YJ3 A;  4FLL A;  1R58 A;  1BOA A;  4Z7M A;  1QXY A;  2P99 A;  1WKM A;  4U1B A;  2P98 A;  1KQ0 A;  4FKC A;  4S01 A;  2BWT A;  2GG8 A;  1BN5 A;  2Q94 A;  2BWS A;  4RZY A;  1YW9 A;  2GU6 A;  4IU6 A;  1QXZ A;  2Q93 A;  1C22 A;  1C24 A;  3CB6 A;  2DFI A;  1YW7 A;  4OOK A;  5D6F A;  3MAT A;  2Q8K A;  3MX6 A;  2V6C A;  2OAZ A;  1XGO A;  2NQ6 A;  2GG9 A;  4S00 A;  2BHC A;  2GG0 A;  3L24 A;  4S2R P;  3IU7 A;  4FUK A;  4U6W A;  2BWV A;  2BHD A;  3FM3 A;  1XGM A;  4MAT A;  3S6B A;  4IKT A;  1KQ9 A;  4KM3 A;  4ZNG A;  3PKC A;  2EA2 A;  2GZ5 A;  1WL6 A;  2BWU A;  4FO7 A;  2EVC A;  4FLK A;  5CNX A;  2EVM A;  5FCH A;  5CDE A;  4U6C A;  2NQ7 A;  4IDY A;  3ROR A;  2EVO A;  2GGB A;  1A16 A;  1M35 A;  2V3Z A;  4A6W A;  4EGE A;  3L7G A;  2V3Y A;  3IG4 A;  1B59 A;  4S2T P;  2BWW A;  2B3H A;  4FLI A;  2GU5 A;  2Q96 A;  1QXW A;  1WLR A;  5JHU A;  2B3L A;  2BN7 A;  2GG5 A;  4RZZ A;  1W2M A;  2ZSG A;  4IEC A;  4B28 A;  1XNZ A;  2GTX A;  1C23 A;  2ADU A;  1KP0 A;  3MR1 A;  3PKD A;  4U69 A;  2BHA A;  2BB7 A;  5D6E A;  4A6V A;  4R60 A;  3TAV A;  3TB5 A;  2IW2 A;  5FCF A;  4U75 A;  1JAW A;  4ZWP A;  3FMQ A;  1YW8 A;  4U76 A;  4ZWU A;  4IKS A;  4U6E A;  2B3K A;  4U6J A;  4PNC A;  4U73 A;  3PKA A;  4QR8 A;  1B6A A;  5JFR A;  2Q95 A;  4U70 A;  1O0X A;  3IU9 A;  4U71 A;  4IPA A;  3Q6D A;  2G6P A;  2MAT A;  2P9A A;  5CDL A;  2HOW A;  4IKR A;  5JI6 A;  4HXX A;  2EA4 A;  1C21 A;  4IKU A;  5CE6 A;  1PV9 A;  1WY2 A;  2GGC A;  1QZY A;  3CB5 A;  3PKB A;  3FMR A;  4U6Z A;  2GG7 A;  5CIK A;  1WBQ A;  2GU7 A;  2OKN A;  3IU8 A;  4FO8 A;  3D27 A;  4JUQ A;  2BWY A;  2BWX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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