1C22A

E. coli methionine aminopeptidase: trifluoromethionine complex
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords METHIONINE AMINOPEPTIDASE
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 1999-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1c22A00
1YVMA 2ADUA 2GU5A 2G6PA 1BOAA 3CB6A 1XGSA 4IKSA 4S01A 1WN1A 2P98A 4EGEA 2EA4A 5CDLA 2B3KA 2OKNA 3PKEA 2V3YA 2V3ZA 3MX6A 4FLLA 4FLIA 5CE6A 1YW7A 4B28A 1C27A 1R5GA 2GG0A 4U75A 2V6CA 3IU9A 4A6VA 4MATA 5D6EA 3BIQA 1WLRA 5CDEA 2GA2A 3RVAA 1KP0A 2GG2A 3PKAA 2GU7A 4A6WA 3FMQA 4FUKA 1A16A 2V3XA 5JI6A 5CNXA 2BWXA 4IPAA 1KQ0A 2BHBA 2Q94A 4RZZA 3PKDA 1XGOA 2BWVA 2DFIA 1M35A 2BWUA 3TB5A 3TAVA 2EVOA 4U71A 1WL9A 2GZ5A 3BITA 4U6CA 2GG7A 5JHUA 5E5BA 2NQ6A 1WKMA 2GG9A 3CTZA 3D27A 1XGMA 1YW8A 4ZNGA 2BWWA 4IKTA 2EVMA 1O0XA 2EVCA 1WL6A 4U73A 1YW9A 1WY2A 1QZYA 2HOWA 1YJ3A 3PKCA 4IKUA 1Y1NA 2Q92A 4R60A 4KM3A 4FLJA 1QXWA 2ZSGA 4FO7A 4U6EA 1C22A 2GU6A 1CHMA 2BHAA 2GU4A 4U69A 4U76A 2NQ7A 3L24A 2B3HA 2GGCA 4S00A 2BHCA 1C21A 4PV4A 4IKRA 5FCHA 5FCFA 1PV9A 1W2MA 2GG8A 3CB5A 4U1BA 4ZWUA 4RGZ1 1W7VA 4S2RP 1KQ9A 2GTXA 2BN7A 1MATA 2BHDA 2P99A 3PKBA 5CDVA 3BIPA 3Q6DA 4JUQA 4PNCA 2Q93A 2MATA 4FLKA 2GG3A 4Z7MA 1QXZA 5CIKA 1JAWA 3IU7A 4ZWOA 2BWYA 4S2TP 2Q95A 4QR8A 1BN5A 2OAZA 4IECA 2GGBA 3FMRA 4U70A 2IW2A 1R5HA 4HXXA 3L7GA 1C24A 2BB7A 4IU6A 2Q8KA 4U6ZA 2BWSA 3S6BA 2B3LA 4U6JA 2GG5A 3FM3A 4ZWPA 3MR1A 2BH3A 3IU8A 4FKCA 4IDYA 4IF7A 1R58A 4U6WA 1XGNA 1QXYA 2EA2A 4RZYA 3MATA 1N51A 1XNZA 5CLSA 2BWTA 3IG4A 4FO8A 1C23A 1B6AA 5D6FA 2Q96A 3RORA 4OOKA 2P9AA 5JFRA 1WBQA 1B59A
chains in the Genus database with same CATH superfamily
1YVMA 2ADUA 2GU5A 2G6PA 1BOAA 3CB6A 1XGSA 4IKSA 4S01A 1WN1A 2P98A 4EGEA 2EA4A 5CDLA 2B3KA 2OKNA 3PKEA 2V3YA 2V3ZA 3MX6A 4FLLA 4FLIA 5CE6A 1YW7A 4B28A 1C27A 1R5GA 2GG0A 4U75A 2V6CA 3IU9A 4A6VA 4MATA 5D6EA 3BIQA 1WLRA 5CDEA 2GA2A 3RVAA 1KP0A 2GG2A 3PKAA 2GU7A 4A6WA 3FMQA 4FUKA 1A16A 2V3XA 5JI6A 5CNXA 2BWXA 4IPAA 1KQ0A 2BHBA 2Q94A 4RZZA 3PKDA 1XGOA 2BWVA 2DFIA 1M35A 2BWUA 3TB5A 3TAVA 2EVOA 4U71A 1WL9A 2GZ5A 3BITA 4U6CA 2GG7A 5JHUA 5E5BA 2NQ6A 1WKMA 2GG9A 3CTZA 3D27A 1XGMA 1YW8A 4ZNGA 2BWWA 4IKTA 2EVMA 1O0XA 2EVCA 1WL6A 4U73A 1YW9A 1WY2A 1QZYA 2HOWA 1YJ3A 3PKCA 4IKUA 1Y1NA 2Q92A 4R60A 4KM3A 4FLJA 1QXWA 2ZSGA 4FO7A 4U6EA 1C22A 2GU6A 1CHMA 2BHAA 2GU4A 4U69A 4U76A 2NQ7A 3L24A 2B3HA 2GGCA 4S00A 2BHCA 1C21A 4PV4A 4IKRA 5FCHA 5FCFA 1PV9A 1W2MA 2GG8A 3CB5A 4U1BA 4ZWUA 4RGZ1 1W7VA 4S2RP 1KQ9A 2GTXA 2BN7A 1MATA 2BHDA 2P99A 3PKBA 5CDVA 3BIPA 3Q6DA 4JUQA 4PNCA 2Q93A 2MATA 4FLKA 2GG3A 4Z7MA 1QXZA 5CIKA 1JAWA 3IU7A 4ZWOA 2BWYA 4S2TP 2Q95A 4QR8A 1BN5A 2OAZA 4IECA 2GGBA 3FMRA 4U70A 2IW2A 1R5HA 4HXXA 3L7GA 1C24A 2BB7A 4IU6A 2Q8KA 4U6ZA 2BWSA 3S6BA 2B3LA 4U6JA 2GG5A 3FM3A 4ZWPA 3MR1A 2BH3A 3IU8A 4FKCA 4IDYA 4IF7A 1R58A 4U6WA 1XGNA 1QXYA 2EA2A 4RZYA 3MATA 1N51A 1XNZA 5CLSA 2BWTA 3IG4A 4FO8A 1C23A 1B6AA 5D6FA 2Q96A 3RORA 4OOKA 2P9AA 5JFRA 1WBQA 1B59A
chains in the Genus database with same CATH topology
1YVMA 2ADUA 2GU5A 2G6PA 1BOAA 3CB6A 1XGSA 4IKSA 4S01A 1WN1A 2P98A 4EGEA 2EA4A 5CDLA 2B3KA 2OKNA 3PKEA 2V3YA 2V3ZA 3MX6A 4FLLA 4FLIA 5CE6A 1YW7A 4B28A 1C27A 1R5GA 2GG0A 4U75A 2V6CA 3IU9A 4A6VA 4MATA 5D6EA 3BIQA 1WLRA 5CDEA 2GA2A 3RVAA 1KP0A 2GG2A 3PKAA 2GU7A 4A6WA 3FMQA 4FUKA 1A16A 2V3XA 5JI6A 5CNXA 2BWXA 4IPAA 1KQ0A 2BHBA 2Q94A 4RZZA 3PKDA 1XGOA 2BWVA 2DFIA 1M35A 2BWUA 3TB5A 3TAVA 2EVOA 4U71A 1WL9A 2GZ5A 3BITA 4U6CA 2GG7A 5JHUA 5E5BA 2NQ6A 1WKMA 2GG9A 3CTZA 3D27A 1XGMA 1YW8A 4ZNGA 2BWWA 4IKTA 2EVMA 1O0XA 2EVCA 1WL6A 4U73A 1YW9A 1WY2A 1QZYA 2HOWA 1YJ3A 3PKCA 4IKUA 1Y1NA 2Q92A 4R60A 4KM3A 4FLJA 1QXWA 2ZSGA 4FO7A 4U6EA 1C22A 2GU6A 1CHMA 2BHAA 2GU4A 4U69A 4U76A 2NQ7A 3L24A 2B3HA 2GGCA 4S00A 2BHCA 1C21A 4PV4A 4IKRA 5FCHA 5FCFA 1PV9A 1W2MA 2GG8A 3CB5A 4U1BA 4ZWUA 4RGZ1 1W7VA 4S2RP 1KQ9A 2GTXA 2BN7A 1MATA 2BHDA 2P99A 3PKBA 5CDVA 3BIPA 3Q6DA 4JUQA 4PNCA 2Q93A 2MATA 4FLKA 2GG3A 4Z7MA 1QXZA 5CIKA 1JAWA 3IU7A 4ZWOA 2BWYA 4S2TP 2Q95A 4QR8A 1BN5A 2OAZA 4IECA 2GGBA 3FMRA 4U70A 2IW2A 1R5HA 4HXXA 3L7GA 1C24A 2BB7A 4IU6A 2Q8KA 4U6ZA 2BWSA 3S6BA 2B3LA 4U6JA 2GG5A 3FM3A 4ZWPA 3MR1A 2BH3A 3IU8A 4FKCA 4IDYA 4IF7A 1R58A 4U6WA 1XGNA 1QXYA 2EA2A 4RZYA 3MATA 1N51A 1XNZA 5CLSA 2BWTA 3IG4A 4FO8A 1C23A 1B6AA 5D6FA 2Q96A 3RORA 4OOKA 2P9AA 5JFRA 1WBQA 1B59A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YVM A;  2ADU A;  2GU5 A;  2G6P A;  1BOA A;  3CB6 A;  1XGS A;  4IKS A;  4S01 A;  1WN1 A;  2P98 A;  4EGE A;  2EA4 A;  5CDL A;  2B3K A;  2OKN A;  3PKE A;  2V3Y A;  2V3Z A;  3MX6 A;  4FLL A;  4FLI A;  5CE6 A;  1YW7 A;  4B28 A;  1C27 A;  1R5G A;  2GG0 A;  4U75 A;  2V6C A;  3IU9 A;  4A6V A;  4MAT A;  5D6E A;  3BIQ A;  1WLR A;  5CDE A;  2GA2 A;  3RVA A;  1KP0 A;  2GG2 A;  3PKA A;  2GU7 A;  4A6W A;  3FMQ A;  4FUK A;  1A16 A;  2V3X A;  5JI6 A;  5CNX A;  2BWX A;  4IPA A;  1KQ0 A;  2BHB A;  2Q94 A;  4RZZ A;  3PKD A;  1XGO A;  2BWV A;  2DFI A;  1M35 A;  2BWU A;  3TB5 A;  3TAV A;  2EVO A;  4U71 A;  1WL9 A;  2GZ5 A;  3BIT A;  4U6C A;  2GG7 A;  5JHU A;  5E5B A;  2NQ6 A;  1WKM A;  2GG9 A;  3CTZ A;  3D27 A;  1XGM A;  1YW8 A;  4ZNG A;  2BWW A;  4IKT A;  2EVM A;  1O0X A;  2EVC A;  1WL6 A;  4U73 A;  1YW9 A;  1WY2 A;  1QZY A;  2HOW A;  1YJ3 A;  3PKC A;  4IKU A;  1Y1N A;  2Q92 A;  4R60 A;  4KM3 A;  4FLJ A;  1QXW A;  2ZSG A;  4FO7 A;  4U6E A;  1C22 A;  2GU6 A;  1CHM A;  2BHA A;  2GU4 A;  4U69 A;  4U76 A;  2NQ7 A;  3L24 A;  2B3H A;  2GGC A;  4S00 A;  2BHC A;  1C21 A;  4PV4 A;  4IKR A;  5FCH A;  5FCF A;  1PV9 A;  1W2M A;  2GG8 A;  3CB5 A;  4U1B A;  4ZWU A;  4RGZ 1;  1W7V A;  4S2R P;  1KQ9 A;  2GTX A;  2BN7 A;  1MAT A;  2BHD A;  2P99 A;  3PKB A;  5CDV A;  3BIP A;  3Q6D A;  4JUQ A;  4PNC A;  2Q93 A;  2MAT A;  4FLK A;  2GG3 A;  4Z7M A;  1QXZ A;  5CIK A;  1JAW A;  3IU7 A;  4ZWO A;  2BWY A;  4S2T P;  2Q95 A;  4QR8 A;  1BN5 A;  2OAZ A;  4IEC A;  2GGB A;  3FMR A;  4U70 A;  2IW2 A;  1R5H A;  4HXX A;  3L7G A;  1C24 A;  2BB7 A;  4IU6 A;  2Q8K A;  4U6Z A;  2BWS A;  3S6B A;  2B3L A;  4U6J A;  2GG5 A;  3FM3 A;  4ZWP A;  3MR1 A;  2BH3 A;  3IU8 A;  4FKC A;  4IDY A;  4IF7 A;  1R58 A;  4U6W A;  1XGN A;  1QXY A;  2EA2 A;  4RZY A;  3MAT A;  1N51 A;  1XNZ A;  5CLS A;  2BWT A;  3IG4 A;  4FO8 A;  1C23 A;  1B6A A;  5D6F A;  2Q96 A;  3ROR A;  4OOK A;  2P9A A;  5JFR A;  1WBQ A;  1B59 A; 
#chains in the Genus database with same CATH topology
 1YVM A;  2ADU A;  2GU5 A;  2G6P A;  1BOA A;  3CB6 A;  1XGS A;  4IKS A;  4S01 A;  1WN1 A;  2P98 A;  4EGE A;  2EA4 A;  5CDL A;  2B3K A;  2OKN A;  3PKE A;  2V3Y A;  2V3Z A;  3MX6 A;  4FLL A;  4FLI A;  5CE6 A;  1YW7 A;  4B28 A;  1C27 A;  1R5G A;  2GG0 A;  4U75 A;  2V6C A;  3IU9 A;  4A6V A;  4MAT A;  5D6E A;  3BIQ A;  1WLR A;  5CDE A;  2GA2 A;  3RVA A;  1KP0 A;  2GG2 A;  3PKA A;  2GU7 A;  4A6W A;  3FMQ A;  4FUK A;  1A16 A;  2V3X A;  5JI6 A;  5CNX A;  2BWX A;  4IPA A;  1KQ0 A;  2BHB A;  2Q94 A;  4RZZ A;  3PKD A;  1XGO A;  2BWV A;  2DFI A;  1M35 A;  2BWU A;  3TB5 A;  3TAV A;  2EVO A;  4U71 A;  1WL9 A;  2GZ5 A;  3BIT A;  4U6C A;  2GG7 A;  5JHU A;  5E5B A;  2NQ6 A;  1WKM A;  2GG9 A;  3CTZ A;  3D27 A;  1XGM A;  1YW8 A;  4ZNG A;  2BWW A;  4IKT A;  2EVM A;  1O0X A;  2EVC A;  1WL6 A;  4U73 A;  1YW9 A;  1WY2 A;  1QZY A;  2HOW A;  1YJ3 A;  3PKC A;  4IKU A;  1Y1N A;  2Q92 A;  4R60 A;  4KM3 A;  4FLJ A;  1QXW A;  2ZSG A;  4FO7 A;  4U6E A;  1C22 A;  2GU6 A;  1CHM A;  2BHA A;  2GU4 A;  4U69 A;  4U76 A;  2NQ7 A;  3L24 A;  2B3H A;  2GGC A;  4S00 A;  2BHC A;  1C21 A;  4PV4 A;  4IKR A;  5FCH A;  5FCF A;  1PV9 A;  1W2M A;  2GG8 A;  3CB5 A;  4U1B A;  4ZWU A;  4RGZ 1;  1W7V A;  4S2R P;  1KQ9 A;  2GTX A;  2BN7 A;  1MAT A;  2BHD A;  2P99 A;  3PKB A;  5CDV A;  3BIP A;  3Q6D A;  4JUQ A;  4PNC A;  2Q93 A;  2MAT A;  4FLK A;  2GG3 A;  4Z7M A;  1QXZ A;  5CIK A;  1JAW A;  3IU7 A;  4ZWO A;  2BWY A;  4S2T P;  2Q95 A;  4QR8 A;  1BN5 A;  2OAZ A;  4IEC A;  2GGB A;  3FMR A;  4U70 A;  2IW2 A;  1R5H A;  4HXX A;  3L7G A;  1C24 A;  2BB7 A;  4IU6 A;  2Q8K A;  4U6Z A;  2BWS A;  3S6B A;  2B3L A;  4U6J A;  2GG5 A;  3FM3 A;  4ZWP A;  3MR1 A;  2BH3 A;  3IU8 A;  4FKC A;  4IDY A;  4IF7 A;  1R58 A;  4U6W A;  1XGN A;  1QXY A;  2EA2 A;  4RZY A;  3MAT A;  1N51 A;  1XNZ A;  5CLS A;  2BWT A;  3IG4 A;  4FO8 A;  1C23 A;  1B6A A;  5D6F A;  2Q96 A;  3ROR A;  4OOK A;  2P9A A;  5JFR A;  1WBQ A;  1B59 A; 
#chains in the Genus database with same CATH homology
 1YVM A;  2ADU A;  2GU5 A;  2G6P A;  1BOA A;  3CB6 A;  1XGS A;  4IKS A;  4S01 A;  1WN1 A;  2P98 A;  4EGE A;  2EA4 A;  5CDL A;  2B3K A;  2OKN A;  3PKE A;  2V3Y A;  2V3Z A;  3MX6 A;  4FLL A;  4FLI A;  5CE6 A;  1YW7 A;  4B28 A;  1C27 A;  1R5G A;  2GG0 A;  4U75 A;  2V6C A;  3IU9 A;  4A6V A;  4MAT A;  5D6E A;  3BIQ A;  1WLR A;  5CDE A;  2GA2 A;  3RVA A;  1KP0 A;  2GG2 A;  3PKA A;  2GU7 A;  4A6W A;  3FMQ A;  4FUK A;  1A16 A;  2V3X A;  5JI6 A;  5CNX A;  2BWX A;  4IPA A;  1KQ0 A;  2BHB A;  2Q94 A;  4RZZ A;  3PKD A;  1XGO A;  2BWV A;  2DFI A;  1M35 A;  2BWU A;  3TB5 A;  3TAV A;  2EVO A;  4U71 A;  1WL9 A;  2GZ5 A;  3BIT A;  4U6C A;  2GG7 A;  5JHU A;  5E5B A;  2NQ6 A;  1WKM A;  2GG9 A;  3CTZ A;  3D27 A;  1XGM A;  1YW8 A;  4ZNG A;  2BWW A;  4IKT A;  2EVM A;  1O0X A;  2EVC A;  1WL6 A;  4U73 A;  1YW9 A;  1WY2 A;  1QZY A;  2HOW A;  1YJ3 A;  3PKC A;  4IKU A;  1Y1N A;  2Q92 A;  4R60 A;  4KM3 A;  4FLJ A;  1QXW A;  2ZSG A;  4FO7 A;  4U6E A;  1C22 A;  2GU6 A;  1CHM A;  2BHA A;  2GU4 A;  4U69 A;  4U76 A;  2NQ7 A;  3L24 A;  2B3H A;  2GGC A;  4S00 A;  2BHC A;  1C21 A;  4PV4 A;  4IKR A;  5FCH A;  5FCF A;  1PV9 A;  1W2M A;  2GG8 A;  3CB5 A;  4U1B A;  4ZWU A;  4RGZ 1;  1W7V A;  4S2R P;  1KQ9 A;  2GTX A;  2BN7 A;  1MAT A;  2BHD A;  2P99 A;  3PKB A;  5CDV A;  3BIP A;  3Q6D A;  4JUQ A;  4PNC A;  2Q93 A;  2MAT A;  4FLK A;  2GG3 A;  4Z7M A;  1QXZ A;  5CIK A;  1JAW A;  3IU7 A;  4ZWO A;  2BWY A;  4S2T P;  2Q95 A;  4QR8 A;  1BN5 A;  2OAZ A;  4IEC A;  2GGB A;  3FMR A;  4U70 A;  2IW2 A;  1R5H A;  4HXX A;  3L7G A;  1C24 A;  2BB7 A;  4IU6 A;  2Q8K A;  4U6Z A;  2BWS A;  3S6B A;  2B3L A;  4U6J A;  2GG5 A;  3FM3 A;  4ZWP A;  3MR1 A;  2BH3 A;  3IU8 A;  4FKC A;  4IDY A;  4IF7 A;  1R58 A;  4U6W A;  1XGN A;  1QXY A;  2EA2 A;  4RZY A;  3MAT A;  1N51 A;  1XNZ A;  5CLS A;  2BWT A;  3IG4 A;  4FO8 A;  1C23 A;  1B6A A;  5D6F A;  2Q96 A;  3ROR A;  4OOK A;  2P9A A;  5JFR A;  1WBQ A;  1B59 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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