1CA1A

Alpha-toxin from clostridium perfringens
Total Genus 137
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
137
sequence length
370
structure length
370
Chain Sequence
WDGKIDGTGTHAMIVTQGVSILENDLSKNEPESVRKNLEILKENMHELQLGSTYPDYDKNAYDLYQDHFWDPDTDNNFSKDNSWYLAYSIPDTGESQIRKFSALARYEWQRGNYKQATFYLGEAMHYFGDIDTPYHPANVTAVDSAGHVKFETFAEERKEQYKINTVGCKTNEDFYADILKNKDFNAWSKEYARGFAKTGKSIYYSHASMSHSWDDWDYAAKVTLANSQKGTAGYIYRFLHDVSEGNDPSVGKNVKELVAYISTSGEKDAGTDDYMYFGIKTKDGKTQEWEMDNPGNDFMTGSKDTYTFKLKDENLKIDDIQNMWIRKRKYTAFPDAYKPENIKVIANGKVVVDKDINEWISGNSTYNIK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the key toxin in gas gangrene.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium perfringens
molecule keywords ALPHA-TOXIN
total genus 137
structure length 370
sequence length 370
ec nomenclature ec 3.1.4.3: Phospholipase C.
pdb deposition date 1998-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00882 Zn_dep_PLPC Zinc dependent phospholipase C
A PF01477 PLAT PLAT/LH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.575.10 Mainly Alpha Orthogonal Bundle P1 Nuclease P1 Nuclease 1ca1A01
2.60.60.20 Mainly Beta Sandwich Lipoxygenase-1 PLAT/LH2 domain 1ca1A02
1P6DA 1AH7A 4QWTA 1AK0A 5FB9A 1Y4KA 4JDGA 1N8SA 1RRLA 1W52X 5EEOA 5FBAA 1P6EA 4WFOA 1FGRA 1CA1A 1F8NA 2HUCA 4NREA 1GYGA 4CXVA 3O8YA 3V98A 5FBGA 1YGEA 4CWMA 5FBBA 1LOXA 3BNCA 3V92A 1LPBB 1FGQA 2FFZA 5FBFA 2WY6A 1RP1A 3W52A 1IK3A 2P0MA 3FG4A 2PVSA 1FGMA 1QMDA 1N8QA 1OLPA 3FG1A 3V99A 1FGTA 1P5XA 1JNQA 2OXEA 3BNEA 3SNGA 3CWZB 1QM6A 3FG3A 1HU9A 5FBCA 1ROVA 3PZWA 1NO3A 2IUJA 1FGOA 1GPLA 1LNHA 3BNDA 2FNQA 1BU8A 3BNBA 1KHOA 1ETHA 2WXTA 1LPAB 4DJ4A 2WXUA 3VF1A 1HPLA 1RRHA 2IUKA 4WHAA 2FGNA 2PPLA 4CXPA 4CXOA 5FBDA 2SBLA
chains in the Genus database with same CATH superfamily
1P6DA 1AH7A 4QEYA 4QWTA 1AK0A 5FB9A 1Y4KA 4JDGA 1N8SA 1RRLA 1W52X 5EEOA 2KXTA 5FBAA 1P6EA 4WFOA 1FGRA 2XHJA 1CA1A 1F8NA 2HUCA 4NREA 1GYGA 4CXVA 3O8YA 3V98A 5FBGA 3U6GA 1YGEA 4CWMA 5FBBA 1LOXA 3BNCA 3V92A 1LPBB 1FGQA 2FFZA 5FBFA 2WY6A 1RP1A 3W52A 1IK3A 2P0MA 3FG4A 2PVSA 2LRGA 1FGMA 1QMDA 1N8QA 1OLPA 3FG1A 3V99A 1FGTA 1P5XA 1JNQA 2QNGA 2LGEA 2OXEA 2XFEA 3BNEA 3SNGA 3IBZA 3CWZB 1QM6A 3FG3A 1HU9A 2XFDA 5FBCA 1ROVA 3PZWA 1NO3A 2IUJA 2LG7A 1FGOA 1GPLA 1LNHA 2QZ7A 3BNDA 2FNQA 1BU8A 3BNBA 1KHOA 1ETHA 2WXTA 1LPAB 4DJ4A 2WXUA 2KXVA 3VF1A 2XHHA 1HPLA 1RRHA 2IUKA 4WHAA 2FGNA 2PPLA 4CXPA 4CXOA 5FBDA 2SBLA
chains in the Genus database with same CATH topology
1P6DA 1AH7A 4QWTA 1AK0A 5FB9A 1Y4KA 4JDGA 1N8SA 1RRLA 1W52X 5EEOA 5FBAA 1P6EA 4WFOA 1FGRA 1CA1A 1F8NA 2HUCA 4NREA 1GYGA 4CXVA 3O8YA 3V98A 5FBGA 1YGEA 4CWMA 5FBBA 1LOXA 3BNCA 3V92A 1LPBB 1FGQA 2FFZA 5FBFA 2WY6A 1RP1A 3W52A 1IK3A 2P0MA 3FG4A 2PVSA 1FGMA 1QMDA 1N8QA 1OLPA 3FG1A 3V99A 1FGTA 1P5XA 1JNQA 2OXEA 3BNEA 3SNGA 3CWZB 1QM6A 3FG3A 1HU9A 5FBCA 1ROVA 3PZWA 1NO3A 2IUJA 1FGOA 1GPLA 1LNHA 3BNDA 2FNQA 1BU8A 3BNBA 1KHOA 1ETHA 2WXTA 1LPAB 4DJ4A 2WXUA 3VF1A 1HPLA 1RRHA 2IUKA 4WHAA 2FGNA 2PPLA 4CXPA 4CXOA 5FBDA 2SBLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P6D A;  1AH7 A;  4QWT A;  1AK0 A;  5FB9 A;  1Y4K A;  4JDG A;  1N8S A;  1RRL A;  1W52 X;  5EEO A;  5FBA A;  1P6E A;  4WFO A;  1FGR A;  1CA1 A;  1F8N A;  2HUC A;  4NRE A;  1GYG A;  4CXV A;  3O8Y A;  3V98 A;  5FBG A;  1YGE A;  4CWM A;  5FBB A;  1LOX A;  3BNC A;  3V92 A;  1LPB B;  1FGQ A;  2FFZ A;  5FBF A;  2WY6 A;  1RP1 A;  3W52 A;  1IK3 A;  2P0M A;  3FG4 A;  2PVS A;  1FGM A;  1QMD A;  1N8Q A;  1OLP A;  3FG1 A;  3V99 A;  1FGT A;  1P5X A;  1JNQ A;  2OXE A;  3BNE A;  3SNG A;  3CWZ B;  1QM6 A;  3FG3 A;  1HU9 A;  5FBC A;  1ROV A;  3PZW A;  1NO3 A;  2IUJ A;  1FGO A;  1GPL A;  1LNH A;  3BND A;  2FNQ A;  1BU8 A;  3BNB A;  1KHO A;  1ETH A;  2WXT A;  1LPA B;  4DJ4 A;  2WXU A;  3VF1 A;  1HPL A;  1RRH A;  2IUK A;  4WHA A;  2FGN A;  2PPL A;  4CXP A;  4CXO A;  5FBD A;  2SBL A; 
#chains in the Genus database with same CATH topology
 1P6D A;  1AH7 A;  4QEY A;  4QWT A;  1AK0 A;  5FB9 A;  1Y4K A;  4JDG A;  1N8S A;  1RRL A;  1W52 X;  5EEO A;  2KXT A;  5FBA A;  1P6E A;  4WFO A;  1FGR A;  2XHJ A;  1CA1 A;  1F8N A;  2HUC A;  4NRE A;  1GYG A;  4CXV A;  3O8Y A;  3V98 A;  5FBG A;  3U6G A;  1YGE A;  4CWM A;  5FBB A;  1LOX A;  3BNC A;  3V92 A;  1LPB B;  1FGQ A;  2FFZ A;  5FBF A;  2WY6 A;  1RP1 A;  3W52 A;  1IK3 A;  2P0M A;  3FG4 A;  2PVS A;  2LRG A;  1FGM A;  1QMD A;  1N8Q A;  1OLP A;  3FG1 A;  3V99 A;  1FGT A;  1P5X A;  1JNQ A;  2QNG A;  2LGE A;  2OXE A;  2XFE A;  3BNE A;  3SNG A;  3IBZ A;  3CWZ B;  1QM6 A;  3FG3 A;  1HU9 A;  2XFD A;  5FBC A;  1ROV A;  3PZW A;  1NO3 A;  2IUJ A;  2LG7 A;  1FGO A;  1GPL A;  1LNH A;  2QZ7 A;  3BND A;  2FNQ A;  1BU8 A;  3BNB A;  1KHO A;  1ETH A;  2WXT A;  1LPA B;  4DJ4 A;  2WXU A;  2KXV A;  3VF1 A;  2XHH A;  1HPL A;  1RRH A;  2IUK A;  4WHA A;  2FGN A;  2PPL A;  4CXP A;  4CXO A;  5FBD A;  2SBL A; 
#chains in the Genus database with same CATH homology
 1P6D A;  1AH7 A;  4QWT A;  1AK0 A;  5FB9 A;  1Y4K A;  4JDG A;  1N8S A;  1RRL A;  1W52 X;  5EEO A;  5FBA A;  1P6E A;  4WFO A;  1FGR A;  1CA1 A;  1F8N A;  2HUC A;  4NRE A;  1GYG A;  4CXV A;  3O8Y A;  3V98 A;  5FBG A;  1YGE A;  4CWM A;  5FBB A;  1LOX A;  3BNC A;  3V92 A;  1LPB B;  1FGQ A;  2FFZ A;  5FBF A;  2WY6 A;  1RP1 A;  3W52 A;  1IK3 A;  2P0M A;  3FG4 A;  2PVS A;  1FGM A;  1QMD A;  1N8Q A;  1OLP A;  3FG1 A;  3V99 A;  1FGT A;  1P5X A;  1JNQ A;  2OXE A;  3BNE A;  3SNG A;  3CWZ B;  1QM6 A;  3FG3 A;  1HU9 A;  5FBC A;  1ROV A;  3PZW A;  1NO3 A;  2IUJ A;  1FGO A;  1GPL A;  1LNH A;  3BND A;  2FNQ A;  1BU8 A;  3BNB A;  1KHO A;  1ETH A;  2WXT A;  1LPA B;  4DJ4 A;  2WXU A;  3VF1 A;  1HPL A;  1RRH A;  2IUK A;  4WHA A;  2FGN A;  2PPL A;  4CXP A;  4CXO A;  5FBD A;  2SBL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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