1CFAA

Solution structure of a semi-synthetic c5a receptor antagonist at ph 5.2, 303k, nmr, 20 structures
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
71
structure length
71
Chain Sequence
MLQKKIEEIAAKYKHSVVKKCCYDGASVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system/inhibitor
molecule keywords COMPLEMENT 5A SEMI-SYNTHETIC ANTAGONIST
publication title Solution structure of a unique C5a semi-synthetic antagonist: implications in receptor binding.
pubmed rcsb
source organism Homo sapiens
total genus 14
structure length 71
sequence length 71
ec nomenclature
pdb deposition date 1996-09-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01821 ANATO Anaphylotoxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.91.20 Mainly Alpha Up-down Bundle Influenza Virus Matrix Protein; Chain A, domain 1 Anaphylotoxins (complement system) 1cfaA00
4FXKB 4P39A 3KLSA 4P3BA 5JPNB 3CU7A 1C5AA 1KJSA 4WB3A 3HQAA 4WB2A 4HWJA 2A73B 2B39A 4HW5A 4UU9C 1CFAA 3HQBA 4P3AA 5B4PB 4I6OA
chains in the Genus database with same CATH superfamily
4FXKB 4P39A 4ITVA 4D9JA 5CQEA 4PUSA 4IQ4A 3KLSA 4P3BA 5JPNB 3CU7A 3VDXA 1C5AA 2Z16A 1KJSA 4WB3A 3MD2A 1AA7A 3HQAA 1EA3A 4WB2A 4HWJA 5JPMB 4FXGB 2A73B 2B39A 4HW5A 4UU9C 1CFAA 3HQBA 4P3AA 5B4PB 4I6OA
chains in the Genus database with same CATH topology
4FXKB 4P39A 3KLSA 4P3BA 5JPNB 3CU7A 1C5AA 1KJSA 4WB3A 3HQAA 4WB2A 4HWJA 2A73B 2B39A 4HW5A 4UU9C 1CFAA 3HQBA 4P3AA 5B4PB 4I6OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FXK B;  4P39 A;  3KLS A;  4P3B A;  5JPN B;  3CU7 A;  1C5A A;  1KJS A;  4WB3 A;  3HQA A;  4WB2 A;  4HWJ A;  2A73 B;  2B39 A;  4HW5 A;  4UU9 C;  1CFA A;  3HQB A;  4P3A A;  5B4P B;  4I6O A; 
#chains in the Genus database with same CATH topology
 4FXK B;  4P39 A;  4ITV A;  4D9J A;  5CQE A;  4PUS A;  4IQ4 A;  3KLS A;  4P3B A;  5JPN B;  3CU7 A;  3VDX A;  1C5A A;  2Z16 A;  1KJS A;  4WB3 A;  3MD2 A;  1AA7 A;  3HQA A;  1EA3 A;  4WB2 A;  4HWJ A;  5JPM B;  4FXG B;  2A73 B;  2B39 A;  4HW5 A;  4UU9 C;  1CFA A;  3HQB A;  4P3A A;  5B4P B;  4I6O A; 
#chains in the Genus database with same CATH homology
 4FXK B;  4P39 A;  3KLS A;  4P3B A;  5JPN B;  3CU7 A;  1C5A A;  1KJS A;  4WB3 A;  3HQA A;  4WB2 A;  4HWJ A;  2A73 B;  2B39 A;  4HW5 A;  4UU9 C;  1CFA A;  3HQB A;  4P3A A;  5B4P B;  4I6O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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