1CJAA

Actin-fragmin kinase, catalytic domain from physarum polycephalum
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
342
structure length
327
Chain Sequence
AGALWEIEKELFTKLPAPSSAINSHLQPAKPFKVDLSTAVSYNDIGDINWKNLQQFKGIERSEKGTEGLFFVETESGVFIVKRSTNIESETFCSLLCMRLGLHAPKVRVVSSNSEEGTNMLECLAAIDKSFRVITTLANQANILLMELVRGITLNKLTTTSAPEVLTKSTMQQLGSLMALDVIVNNSDRLPIAWTNEGNLDNIMLSERGATVVPIDSKIIPLDASHPHGERVRELLRTLIAHPGHESSQFHSIRDIITLYTGYDVGTEGSISMQEGFLATVRECASFDLDAFERELLSWQESLQKCHNLSISPQAIPFILRMLRIFH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The crystal structure of the Physarum polycephalum actin-fragmin kinase: an atypical protein kinase with a specialized substrate-binding domain.
pubmed doi rcsb
source organism Physarum polycephalum
molecule tags Transferase
molecule keywords PROTEIN (ACTIN-FRAGMIN KINASE)
total genus 99
structure length 327
sequence length 342
chains with identical sequence B
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 1999-04-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF09192 Act-Frag_cataly Actin-fragmin kinase, catalytic
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1070.11 Mainly Alpha Orthogonal Bundle Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5 Phosphatidylinositol 3-/4-kinase, catalytic domain 1cjaA02
3.30.1010.10 Alpha Beta 2-Layer Sandwich Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4 Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4 1cjaA01
2WXPA 2X6IA 4FA6A 2WXNA 2WXJA 4UWFA 4UWGA 3L08A 5G55A 4GB9A 4OVVA 4PS8A 4KZ0A 3R7RA 3PRZA 4HLEA 4FHJA 3QK0A 3L13A 4PH4B 3SD5A 4PS3A 4FADA 2CHXA 5T8IA 4G11A 3NZUA 2WXMA 4UWKA 3R7QA 3ZW3A 4EZLA 4F1SA 5EDSA 2X6FA 1E8WA 4XE0A 3PREA 3APFA 3QAQA 2X38A 3APCA 4XZ4A 2WXQA 3ML8A 2CHWA 2V4LA 3TL5A 2X6HA 3ZVVA 3CSTA 3QJZA 4FJZA 4UWLA 3ENEA 4TV3A 2CHZA 3PS6A 4AOFA 2WXLA 4ANUA 4EZJA 5JHAA 3ML9A 4FLHA 2WXHA 1E8YA 2WXKA 2Y3AA 3MJWA 4OYSA 3S2AA 2WXRA 3DPDA 3TJPA 5ANLA 4TUUA 3IHYA 4WAFA 5JHBA 2WXGA 4EZKA 4ANVA 4HVBA 4ANXA 4ANWA 3HIZA 5ENNA 4URKA 4WWPA 4A55A 3L54A 1HE8A 2WXFA 4UWHA 2X6KA 4WWNA 1E7UA 3OAWA 1E8XA 3ZIMA 3T8MA 5G2NA 3LJ3A 2RD0A 4L2YA 1E7VA 4PS7A 4FJYA 1CJAA 4FULA 2A4ZA 3HHMA 4OVUA 3QARA 3P2BA 3CSFA 4JPSA 4L1BA 3LS8A 4AJWA 3IBEA 4FHKA 4J6IA 2A5UA 1E90A 2WXIA 4WWOA 4DK5A 4L23A 4KZCA 4BFRA 3APDA 1E8ZA 2WXOA 3L16A 2X6JA 3L17A 3NZSA 3DBSA 4XX5A
chains in the Genus database with same CATH superfamily
2WXPA 2X6IA 4FA6A 2WXNA 2WXJA 4UWFA 4UWGA 3L08A 5G55A 4GB9A 4OVVA 4PS8A 4KZ0A 3R7RA 3PRZA 4HLEA 4FHJA 3QK0A 3L13A 4PH4B 3AKLA 3SD5A 4PS3A 4FADA 2CHXA 5T8IA 4G11A 3NZUA 2WXMA 4UWKA 3R7QA 3ZW3A 4EZLA 4F1SA 5EDSA 2X6FA 1E8WA 4XE0A 3PREA 3APFA 3QAQA 2X38A 3APCA 4XZ4A 2WXQA 3ML8A 2CHWA 2V4LA 3TL5A 2X6HA 3ZVVA 3CSTA 3QJZA 4FJZA 4UWLA 3ENEA 4TV3A 2CHZA 3PS6A 4AOFA 2WXLA 4ANUA 4EZJA 5JHAA 3ML9A 4FLHA 2WXHA 1E8YA 2WXKA 2Y3AA 3MJWA 4OYSA 3S2AA 2WXRA 3DPDA 3TJPA 5ANLA 4TUUA 3IHYA 4WAFA 5JHBA 2WXGA 4EZKA 4ANVA 4HVBA 4ANXA 4ANWA 3HIZA 5ENNA 4URKA 4WWPA 4A55A 3L54A 1HE8A 2WXFA 3AKJA 4UWHA 2X6KA 4WWNA 1E7UA 3OAWA 1E8XA 3ZIMA 3T8MA 5G2NA 3LJ3A 2RD0A 4L2YA 1E7VA 4PS7A 4FJYA 1CJAA 4FULA 2A4ZA 3HHMA 4OVUA 3QARA 3P2BA 3CSFA 4JPSA 4L1BA 3AKKA 3LS8A 4AJWA 3IBEA 4FHKA 4J6IA 2A5UA 1E90A 2WXIA 4WWOA 4DK5A 4L23A 4KZCA 4BFRA 3APDA 1E8ZA 2WXOA 3L16A 2X6JA 3L17A 3NZSA 3DBSA 4XX5A
chains in the Genus database with same CATH topology
2WXPA 2X6IA 4FA6A 2WXNA 2WXJA 4UWFA 4UWGA 3L08A 5G55A 4GB9A 4OVVA 4PS8A 4KZ0A 3R7RA 3PRZA 4HLEA 4FHJA 3QK0A 3L13A 4PH4B 3SD5A 4PS3A 4FADA 2CHXA 5T8IA 4G11A 3NZUA 2WXMA 4UWKA 3R7QA 3ZW3A 4EZLA 4F1SA 5EDSA 2X6FA 1E8WA 4XE0A 3PREA 3APFA 3QAQA 2X38A 3APCA 4XZ4A 2WXQA 3ML8A 2CHWA 2V4LA 3TL5A 2X6HA 3ZVVA 3CSTA 3QJZA 4FJZA 4UWLA 3ENEA 4TV3A 2CHZA 3PS6A 4AOFA 2WXLA 4ANUA 4EZJA 5JHAA 3ML9A 4FLHA 2WXHA 1E8YA 2WXKA 2Y3AA 3MJWA 4OYSA 3S2AA 2WXRA 3DPDA 3TJPA 5ANLA 4TUUA 3IHYA 4WAFA 5JHBA 2WXGA 4EZKA 4ANVA 4HVBA 4ANXA 4ANWA 3HIZA 5ENNA 4URKA 4WWPA 4A55A 3L54A 1HE8A 2WXFA 4UWHA 2X6KA 4WWNA 1E7UA 3OAWA 1E8XA 3ZIMA 3T8MA 5G2NA 3LJ3A 2RD0A 4L2YA 1E7VA 4PS7A 4FJYA 1CJAA 4FULA 2A4ZA 3HHMA 4OVUA 3QARA 3P2BA 3CSFA 4JPSA 4L1BA 3LS8A 4AJWA 3IBEA 4FHKA 4J6IA 2A5UA 1E90A 2WXIA 4WWOA 4DK5A 4L23A 4KZCA 4BFRA 3APDA 1E8ZA 2WXOA 3L16A 2X6JA 3L17A 3NZSA 3DBSA 4XX5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WXP A;  2X6I A;  4FA6 A;  2WXN A;  2WXJ A;  4UWF A;  4UWG A;  3L08 A;  5G55 A;  4GB9 A;  4OVV A;  4PS8 A;  4KZ0 A;  3R7R A;  3PRZ A;  4HLE A;  4FHJ A;  3QK0 A;  3L13 A;  4PH4 B;  3SD5 A;  4PS3 A;  4FAD A;  2CHX A;  5T8I A;  4G11 A;  3NZU A;  2WXM A;  4UWK A;  3R7Q A;  3ZW3 A;  4EZL A;  4F1S A;  5EDS A;  2X6F A;  1E8W A;  4XE0 A;  3PRE A;  3APF A;  3QAQ A;  2X38 A;  3APC A;  4XZ4 A;  2WXQ A;  3ML8 A;  2CHW A;  2V4L A;  3TL5 A;  2X6H A;  3ZVV A;  3CST A;  3QJZ A;  4FJZ A;  4UWL A;  3ENE A;  4TV3 A;  2CHZ A;  3PS6 A;  4AOF A;  2WXL A;  4ANU A;  4EZJ A;  5JHA A;  3ML9 A;  4FLH A;  2WXH A;  1E8Y A;  2WXK A;  2Y3A A;  3MJW A;  4OYS A;  3S2A A;  2WXR A;  3DPD A;  3TJP A;  5ANL A;  4TUU A;  3IHY A;  4WAF A;  5JHB A;  2WXG A;  4EZK A;  4ANV A;  4HVB A;  4ANX A;  4ANW A;  3HIZ A;  5ENN A;  4URK A;  4WWP A;  4A55 A;  3L54 A;  1HE8 A;  2WXF A;  4UWH A;  2X6K A;  4WWN A;  1E7U A;  3OAW A;  1E8X A;  3ZIM A;  3T8M A;  5G2N A;  3LJ3 A;  2RD0 A;  4L2Y A;  1E7V A;  4PS7 A;  4FJY A;  1CJA A;  4FUL A;  2A4Z A;  3HHM A;  4OVU A;  3QAR A;  3P2B A;  3CSF A;  4JPS A;  4L1B A;  3LS8 A;  4AJW A;  3IBE A;  4FHK A;  4J6I A;  2A5U A;  1E90 A;  2WXI A;  4WWO A;  4DK5 A;  4L23 A;  4KZC A;  4BFR A;  3APD A;  1E8Z A;  2WXO A;  3L16 A;  2X6J A;  3L17 A;  3NZS A;  3DBS A;  4XX5 A; 
#chains in the Genus database with same CATH topology
 2WXP A;  2X6I A;  4FA6 A;  2WXN A;  2WXJ A;  4UWF A;  4UWG A;  3L08 A;  5G55 A;  4GB9 A;  4OVV A;  4PS8 A;  4KZ0 A;  3R7R A;  3PRZ A;  4HLE A;  4FHJ A;  3QK0 A;  3L13 A;  4PH4 B;  3AKL A;  3SD5 A;  4PS3 A;  4FAD A;  2CHX A;  5T8I A;  4G11 A;  3NZU A;  2WXM A;  4UWK A;  3R7Q A;  3ZW3 A;  4EZL A;  4F1S A;  5EDS A;  2X6F A;  1E8W A;  4XE0 A;  3PRE A;  3APF A;  3QAQ A;  2X38 A;  3APC A;  4XZ4 A;  2WXQ A;  3ML8 A;  2CHW A;  2V4L A;  3TL5 A;  2X6H A;  3ZVV A;  3CST A;  3QJZ A;  4FJZ A;  4UWL A;  3ENE A;  4TV3 A;  2CHZ A;  3PS6 A;  4AOF A;  2WXL A;  4ANU A;  4EZJ A;  5JHA A;  3ML9 A;  4FLH A;  2WXH A;  1E8Y A;  2WXK A;  2Y3A A;  3MJW A;  4OYS A;  3S2A A;  2WXR A;  3DPD A;  3TJP A;  5ANL A;  4TUU A;  3IHY A;  4WAF A;  5JHB A;  2WXG A;  4EZK A;  4ANV A;  4HVB A;  4ANX A;  4ANW A;  3HIZ A;  5ENN A;  4URK A;  4WWP A;  4A55 A;  3L54 A;  1HE8 A;  2WXF A;  3AKJ A;  4UWH A;  2X6K A;  4WWN A;  1E7U A;  3OAW A;  1E8X A;  3ZIM A;  3T8M A;  5G2N A;  3LJ3 A;  2RD0 A;  4L2Y A;  1E7V A;  4PS7 A;  4FJY A;  1CJA A;  4FUL A;  2A4Z A;  3HHM A;  4OVU A;  3QAR A;  3P2B A;  3CSF A;  4JPS A;  4L1B A;  3AKK A;  3LS8 A;  4AJW A;  3IBE A;  4FHK A;  4J6I A;  2A5U A;  1E90 A;  2WXI A;  4WWO A;  4DK5 A;  4L23 A;  4KZC A;  4BFR A;  3APD A;  1E8Z A;  2WXO A;  3L16 A;  2X6J A;  3L17 A;  3NZS A;  3DBS A;  4XX5 A; 
#chains in the Genus database with same CATH homology
 2WXP A;  2X6I A;  4FA6 A;  2WXN A;  2WXJ A;  4UWF A;  4UWG A;  3L08 A;  5G55 A;  4GB9 A;  4OVV A;  4PS8 A;  4KZ0 A;  3R7R A;  3PRZ A;  4HLE A;  4FHJ A;  3QK0 A;  3L13 A;  4PH4 B;  3SD5 A;  4PS3 A;  4FAD A;  2CHX A;  5T8I A;  4G11 A;  3NZU A;  2WXM A;  4UWK A;  3R7Q A;  3ZW3 A;  4EZL A;  4F1S A;  5EDS A;  2X6F A;  1E8W A;  4XE0 A;  3PRE A;  3APF A;  3QAQ A;  2X38 A;  3APC A;  4XZ4 A;  2WXQ A;  3ML8 A;  2CHW A;  2V4L A;  3TL5 A;  2X6H A;  3ZVV A;  3CST A;  3QJZ A;  4FJZ A;  4UWL A;  3ENE A;  4TV3 A;  2CHZ A;  3PS6 A;  4AOF A;  2WXL A;  4ANU A;  4EZJ A;  5JHA A;  3ML9 A;  4FLH A;  2WXH A;  1E8Y A;  2WXK A;  2Y3A A;  3MJW A;  4OYS A;  3S2A A;  2WXR A;  3DPD A;  3TJP A;  5ANL A;  4TUU A;  3IHY A;  4WAF A;  5JHB A;  2WXG A;  4EZK A;  4ANV A;  4HVB A;  4ANX A;  4ANW A;  3HIZ A;  5ENN A;  4URK A;  4WWP A;  4A55 A;  3L54 A;  1HE8 A;  2WXF A;  4UWH A;  2X6K A;  4WWN A;  1E7U A;  3OAW A;  1E8X A;  3ZIM A;  3T8M A;  5G2N A;  3LJ3 A;  2RD0 A;  4L2Y A;  1E7V A;  4PS7 A;  4FJY A;  1CJA A;  4FUL A;  2A4Z A;  3HHM A;  4OVU A;  3QAR A;  3P2B A;  3CSF A;  4JPS A;  4L1B A;  3LS8 A;  4AJW A;  3IBE A;  4FHK A;  4J6I A;  2A5U A;  1E90 A;  2WXI A;  4WWO A;  4DK5 A;  4L23 A;  4KZC A;  4BFR A;  3APD A;  1E8Z A;  2WXO A;  3L16 A;  2X6J A;  3L17 A;  3NZS A;  3DBS A;  4XX5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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