1CW1A

Crystal structure of isocitrate dehydrogenase mutant k230m bound to isocitrate and mn2+
Total Genus 140
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
140
sequence length
415
structure length
415
Chain Sequence
ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHMGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords ISOCITRATE DEHYDROGENASE
publication title Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase.
pubmed doi rcsb
source organism Escherichia coli
total genus 140
structure length 415
sequence length 415
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 1999-08-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 1cw1A00
2QFYA 1XGVA 1PTMA 3UF6A 1W0DA 1OSJA 1XACA 2HI1A 2D4VA 4P69C 1U7NA 3WZWA 1AI3A 5ICDA 3VKZA 1AI2A 4XRXA 7ICDA 1IPDA 3BLVB 4YB4A 1VLCA 3VMKA 2E5MA 5J33A 4ICDA 4KZOA 1G2UA 1DPZA 1YCOA 1XABA 1ZORA 1WPWA 3ICDA 5L58A 3ASJA 4IWHA 2Y42A 5J32A 4AJCA 4I3LA 1GRPA 4AOYA 3BLVA 1V5BA 3AH3A 1IDDA 5J34A 2E0CA 4AOVA 1PB3A 1HQSA 1DR8A 3UDOA 5LGEA 1CW4A 3VL3A 1CW1A 1SJSA 1WALA 4L04A 1TYOA 3TY4A 3DMSA 1IKAA 2UXQA 9ICDA 2Y41A 5GRFB 2DHTA 3R8WA 3MASB 1LWDA 3VL2A 3U9EA 3MARA 2QFVA 1VI1A 4UMXA 3BLXB 1A05A 1XKDA 5HN5A 4WUOA 2AYQA 1BL5A 5GRFA 4XXVA 3U1HA 1R8KA 5HN3A 8ICDA 1PS6A 1CNZA 1GC9A 3MASA 1GC8A 5K11A 5I96A 1PB1A 1V53A 3BLXA 2IV0A 2ZTWA 5I95A 1GROA 4L03A 3FMXX 3LXYA 6ICDA 3WZYA 2UXRA 4UMYA 1HJ6A 5K10A 5HN4A 1YXOA 2D1CA 3US8A 3VMLA 4AJ3A 4AOUA 4HCXA 3VL6A 1T0LA 3VMJA 2Y40A 1XAAA 4I3KA 5GRIB 5L57A 1X0LA 2G4OA 1XADA 3MAPA 3LCBC 1HEXA 2QFWA 3WZXA 1DR0A 4JQPA 4AJSA 5GREA 3FLKA 3VL7A 1IDEA 4AJRA 1IDFA 3WZVA 5GRIA 4XS3A 4Y1PA 5GRHB 5GRLB 4ATYA 4L06A 4F7IA 1CM7A 1CW7A 3INMA 3TY3A 5DE1A 4AJAA 2QFXA 5HN6A 5GREB 3TNGA 4AJBA 1PS7A 3VL4A 1IDCA 2Y3ZA 5GRHA 1V94A 5GRLA 4JA8A 1T09A 3TSNA 3UDUA 1OSIA 1ISOA 1P8FA 1IDMA 4BNPA
chains in the Genus database with same CATH superfamily
2QFYA 1XGVA 1PTMA 3UF6A 1W0DA 1OSJA 1XACA 2HI1A 2D4VA 4P69C 1U7NA 3WZWA 1AI3A 5ICDA 3VKZA 1AI2A 4XRXA 7ICDA 1IPDA 3BLVB 4YB4A 1VLCA 3VMKA 2E5MA 5J33A 4ICDA 4KZOA 1G2UA 1DPZA 1YCOA 1XABA 1ZORA 1WPWA 3ICDA 5L58A 3ASJA 4IWHA 2Y42A 5J32A 4AJCA 4I3LA 1GRPA 4AOYA 3BLVA 1V5BA 3AH3A 1IDDA 5J34A 2E0CA 4AOVA 1PB3A 1HQSA 1DR8A 3UDOA 5LGEA 1CW4A 3VL3A 1CW1A 1SJSA 1WALA 4L04A 1TYOA 3TY4A 3DMSA 1IKAA 2UXQA 9ICDA 2Y41A 5GRFB 2DHTA 3R8WA 3MASB 1LWDA 3VL2A 3U9EA 3MARA 2QFVA 1VI1A 4UMXA 3BLXB 1A05A 1XKDA 5HN5A 4WUOA 2AYQA 1BL5A 5GRFA 4XXVA 3U1HA 1R8KA 5HN3A 8ICDA 1PS6A 1CNZA 1GC9A 3MASA 1GC8A 5K11A 5I96A 1PB1A 1V53A 3BLXA 2IV0A 2ZTWA 5I95A 1GROA 4L03A 3FMXX 3LXYA 6ICDA 3WZYA 2UXRA 4UMYA 1HJ6A 5K10A 5HN4A 1YXOA 2D1CA 3US8A 3VMLA 4AJ3A 4AOUA 4HCXA 3VL6A 1T0LA 3VMJA 2Y40A 1XAAA 4I3KA 5GRIB 5L57A 1X0LA 2G4OA 1XADA 3MAPA 3LCBC 1HEXA 2QFWA 3WZXA 1DR0A 4JQPA 4AJSA 5GREA 3FLKA 3VL7A 1IDEA 4AJRA 1IDFA 3WZVA 5GRIA 4XS3A 4Y1PA 5GRHB 5GRLB 4ATYA 4L06A 4F7IA 1CM7A 1CW7A 3INMA 3TY3A 5DE1A 4AJAA 2QFXA 5HN6A 5GREB 3TNGA 4AJBA 1PS7A 3VL4A 1IDCA 2Y3ZA 5GRHA 1V94A 5GRLA 4JA8A 1T09A 3TSNA 3UDUA 1OSIA 1ISOA 1P8FA 1IDMA 4BNPA
chains in the Genus database with same CATH topology
2QFYA 1XGVA 1PTMA 3UF6A 1W0DA 1OSJA 1XACA 2HI1A 2D4VA 4P69C 1U7NA 3WZWA 1AI3A 5ICDA 3VKZA 1AI2A 4XRXA 7ICDA 1IPDA 3BLVB 4YB4A 1VLCA 3VMKA 2E5MA 5J33A 4ICDA 4KZOA 1G2UA 1DPZA 1YCOA 1XABA 1ZORA 1WPWA 3ICDA 5L58A 3ASJA 4IWHA 2Y42A 5J32A 4AJCA 4I3LA 1GRPA 4AOYA 3BLVA 1V5BA 3AH3A 1IDDA 5J34A 2E0CA 4AOVA 1PB3A 1HQSA 1DR8A 3UDOA 5LGEA 1CW4A 3VL3A 1CW1A 1SJSA 1WALA 4L04A 1TYOA 3TY4A 3DMSA 1IKAA 2UXQA 9ICDA 2Y41A 5GRFB 2DHTA 3R8WA 3MASB 1LWDA 3VL2A 3U9EA 3MARA 2QFVA 1VI1A 4UMXA 3BLXB 1A05A 1XKDA 5HN5A 4WUOA 2AYQA 1BL5A 5GRFA 4XXVA 3U1HA 1R8KA 5HN3A 8ICDA 1PS6A 1CNZA 1GC9A 3MASA 1GC8A 5K11A 5I96A 1PB1A 1V53A 3BLXA 2IV0A 2ZTWA 5I95A 1GROA 4L03A 3FMXX 3LXYA 6ICDA 3WZYA 2UXRA 4UMYA 1HJ6A 5K10A 5HN4A 1YXOA 2D1CA 3US8A 3VMLA 4AJ3A 4AOUA 4HCXA 3VL6A 1T0LA 3VMJA 2Y40A 1XAAA 4I3KA 5GRIB 5L57A 1X0LA 2G4OA 1XADA 3MAPA 3LCBC 1HEXA 2QFWA 3WZXA 1DR0A 4JQPA 4AJSA 5GREA 3FLKA 3VL7A 1IDEA 4AJRA 1IDFA 3WZVA 5GRIA 4XS3A 4Y1PA 5GRHB 5GRLB 4ATYA 4L06A 4F7IA 1CM7A 1CW7A 3INMA 3TY3A 5DE1A 4AJAA 2QFXA 5HN6A 5GREB 3TNGA 4AJBA 1PS7A 3VL4A 1IDCA 2Y3ZA 5GRHA 1V94A 5GRLA 4JA8A 1T09A 3TSNA 3UDUA 1OSIA 1ISOA 1P8FA 1IDMA 4BNPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QFY A;  1XGV A;  1PTM A;  3UF6 A;  1W0D A;  1OSJ A;  1XAC A;  2HI1 A;  2D4V A;  4P69 C;  1U7N A;  3WZW A;  1AI3 A;  5ICD A;  3VKZ A;  1AI2 A;  4XRX A;  7ICD A;  1IPD A;  3BLV B;  4YB4 A;  1VLC A;  3VMK A;  2E5M A;  5J33 A;  4ICD A;  4KZO A;  1G2U A;  1DPZ A;  1YCO A;  1XAB A;  1ZOR A;  1WPW A;  3ICD A;  5L58 A;  3ASJ A;  4IWH A;  2Y42 A;  5J32 A;  4AJC A;  4I3L A;  1GRP A;  4AOY A;  3BLV A;  1V5B A;  3AH3 A;  1IDD A;  5J34 A;  2E0C A;  4AOV A;  1PB3 A;  1HQS A;  1DR8 A;  3UDO A;  5LGE A;  1CW4 A;  3VL3 A;  1CW1 A;  1SJS A;  1WAL A;  4L04 A;  1TYO A;  3TY4 A;  3DMS A;  1IKA A;  2UXQ A;  9ICD A;  2Y41 A;  5GRF B;  2DHT A;  3R8W A;  3MAS B;  1LWD A;  3VL2 A;  3U9E A;  3MAR A;  2QFV A;  1VI1 A;  4UMX A;  3BLX B;  1A05 A;  1XKD A;  5HN5 A;  4WUO A;  2AYQ A;  1BL5 A;  5GRF A;  4XXV A;  3U1H A;  1R8K A;  5HN3 A;  8ICD A;  1PS6 A;  1CNZ A;  1GC9 A;  3MAS A;  1GC8 A;  5K11 A;  5I96 A;  1PB1 A;  1V53 A;  3BLX A;  2IV0 A;  2ZTW A;  5I95 A;  1GRO A;  4L03 A;  3FMX X;  3LXY A;  6ICD A;  3WZY A;  2UXR A;  4UMY A;  1HJ6 A;  5K10 A;  5HN4 A;  1YXO A;  2D1C A;  3US8 A;  3VML A;  4AJ3 A;  4AOU A;  4HCX A;  3VL6 A;  1T0L A;  3VMJ A;  2Y40 A;  1XAA A;  4I3K A;  5GRI B;  5L57 A;  1X0L A;  2G4O A;  1XAD A;  3MAP A;  3LCB C;  1HEX A;  2QFW A;  3WZX A;  1DR0 A;  4JQP A;  4AJS A;  5GRE A;  3FLK A;  3VL7 A;  1IDE A;  4AJR A;  1IDF A;  3WZV A;  5GRI A;  4XS3 A;  4Y1P A;  5GRH B;  5GRL B;  4ATY A;  4L06 A;  4F7I A;  1CM7 A;  1CW7 A;  3INM A;  3TY3 A;  5DE1 A;  4AJA A;  2QFX A;  5HN6 A;  5GRE B;  3TNG A;  4AJB A;  1PS7 A;  3VL4 A;  1IDC A;  2Y3Z A;  5GRH A;  1V94 A;  5GRL A;  4JA8 A;  1T09 A;  3TSN A;  3UDU A;  1OSI A;  1ISO A;  1P8F A;  1IDM A;  4BNP A; 
#chains in the Genus database with same CATH topology
 2QFY A;  1XGV A;  1PTM A;  3UF6 A;  1W0D A;  1OSJ A;  1XAC A;  2HI1 A;  2D4V A;  4P69 C;  1U7N A;  3WZW A;  1AI3 A;  5ICD A;  3VKZ A;  1AI2 A;  4XRX A;  7ICD A;  1IPD A;  3BLV B;  4YB4 A;  1VLC A;  3VMK A;  2E5M A;  5J33 A;  4ICD A;  4KZO A;  1G2U A;  1DPZ A;  1YCO A;  1XAB A;  1ZOR A;  1WPW A;  3ICD A;  5L58 A;  3ASJ A;  4IWH A;  2Y42 A;  5J32 A;  4AJC A;  4I3L A;  1GRP A;  4AOY A;  3BLV A;  1V5B A;  3AH3 A;  1IDD A;  5J34 A;  2E0C A;  4AOV A;  1PB3 A;  1HQS A;  1DR8 A;  3UDO A;  5LGE A;  1CW4 A;  3VL3 A;  1CW1 A;  1SJS A;  1WAL A;  4L04 A;  1TYO A;  3TY4 A;  3DMS A;  1IKA A;  2UXQ A;  9ICD A;  2Y41 A;  5GRF B;  2DHT A;  3R8W A;  3MAS B;  1LWD A;  3VL2 A;  3U9E A;  3MAR A;  2QFV A;  1VI1 A;  4UMX A;  3BLX B;  1A05 A;  1XKD A;  5HN5 A;  4WUO A;  2AYQ A;  1BL5 A;  5GRF A;  4XXV A;  3U1H A;  1R8K A;  5HN3 A;  8ICD A;  1PS6 A;  1CNZ A;  1GC9 A;  3MAS A;  1GC8 A;  5K11 A;  5I96 A;  1PB1 A;  1V53 A;  3BLX A;  2IV0 A;  2ZTW A;  5I95 A;  1GRO A;  4L03 A;  3FMX X;  3LXY A;  6ICD A;  3WZY A;  2UXR A;  4UMY A;  1HJ6 A;  5K10 A;  5HN4 A;  1YXO A;  2D1C A;  3US8 A;  3VML A;  4AJ3 A;  4AOU A;  4HCX A;  3VL6 A;  1T0L A;  3VMJ A;  2Y40 A;  1XAA A;  4I3K A;  5GRI B;  5L57 A;  1X0L A;  2G4O A;  1XAD A;  3MAP A;  3LCB C;  1HEX A;  2QFW A;  3WZX A;  1DR0 A;  4JQP A;  4AJS A;  5GRE A;  3FLK A;  3VL7 A;  1IDE A;  4AJR A;  1IDF A;  3WZV A;  5GRI A;  4XS3 A;  4Y1P A;  5GRH B;  5GRL B;  4ATY A;  4L06 A;  4F7I A;  1CM7 A;  1CW7 A;  3INM A;  3TY3 A;  5DE1 A;  4AJA A;  2QFX A;  5HN6 A;  5GRE B;  3TNG A;  4AJB A;  1PS7 A;  3VL4 A;  1IDC A;  2Y3Z A;  5GRH A;  1V94 A;  5GRL A;  4JA8 A;  1T09 A;  3TSN A;  3UDU A;  1OSI A;  1ISO A;  1P8F A;  1IDM A;  4BNP A; 
#chains in the Genus database with same CATH homology
 2QFY A;  1XGV A;  1PTM A;  3UF6 A;  1W0D A;  1OSJ A;  1XAC A;  2HI1 A;  2D4V A;  4P69 C;  1U7N A;  3WZW A;  1AI3 A;  5ICD A;  3VKZ A;  1AI2 A;  4XRX A;  7ICD A;  1IPD A;  3BLV B;  4YB4 A;  1VLC A;  3VMK A;  2E5M A;  5J33 A;  4ICD A;  4KZO A;  1G2U A;  1DPZ A;  1YCO A;  1XAB A;  1ZOR A;  1WPW A;  3ICD A;  5L58 A;  3ASJ A;  4IWH A;  2Y42 A;  5J32 A;  4AJC A;  4I3L A;  1GRP A;  4AOY A;  3BLV A;  1V5B A;  3AH3 A;  1IDD A;  5J34 A;  2E0C A;  4AOV A;  1PB3 A;  1HQS A;  1DR8 A;  3UDO A;  5LGE A;  1CW4 A;  3VL3 A;  1CW1 A;  1SJS A;  1WAL A;  4L04 A;  1TYO A;  3TY4 A;  3DMS A;  1IKA A;  2UXQ A;  9ICD A;  2Y41 A;  5GRF B;  2DHT A;  3R8W A;  3MAS B;  1LWD A;  3VL2 A;  3U9E A;  3MAR A;  2QFV A;  1VI1 A;  4UMX A;  3BLX B;  1A05 A;  1XKD A;  5HN5 A;  4WUO A;  2AYQ A;  1BL5 A;  5GRF A;  4XXV A;  3U1H A;  1R8K A;  5HN3 A;  8ICD A;  1PS6 A;  1CNZ A;  1GC9 A;  3MAS A;  1GC8 A;  5K11 A;  5I96 A;  1PB1 A;  1V53 A;  3BLX A;  2IV0 A;  2ZTW A;  5I95 A;  1GRO A;  4L03 A;  3FMX X;  3LXY A;  6ICD A;  3WZY A;  2UXR A;  4UMY A;  1HJ6 A;  5K10 A;  5HN4 A;  1YXO A;  2D1C A;  3US8 A;  3VML A;  4AJ3 A;  4AOU A;  4HCX A;  3VL6 A;  1T0L A;  3VMJ A;  2Y40 A;  1XAA A;  4I3K A;  5GRI B;  5L57 A;  1X0L A;  2G4O A;  1XAD A;  3MAP A;  3LCB C;  1HEX A;  2QFW A;  3WZX A;  1DR0 A;  4JQP A;  4AJS A;  5GRE A;  3FLK A;  3VL7 A;  1IDE A;  4AJR A;  1IDF A;  3WZV A;  5GRI A;  4XS3 A;  4Y1P A;  5GRH B;  5GRL B;  4ATY A;  4L06 A;  4F7I A;  1CM7 A;  1CW7 A;  3INM A;  3TY3 A;  5DE1 A;  4AJA A;  2QFX A;  5HN6 A;  5GRE B;  3TNG A;  4AJB A;  1PS7 A;  3VL4 A;  1IDC A;  2Y3Z A;  5GRH A;  1V94 A;  5GRL A;  4JA8 A;  1T09 A;  3TSN A;  3UDU A;  1OSI A;  1ISO A;  1P8F A;  1IDM A;  4BNP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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