1CWWA

Solution structure of the caspase recruitment domain (card) from apaf-1
Total Genus 31
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
31
sequence length
102
structure length
102
Chain Sequence
GPLGSMDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Apoptosis
molecule keywords APOPTOTIC PROTEASE ACTIVATING FACTOR 1
total genus 31
structure length 102
sequence length 102
ec nomenclature
pdb deposition date 1999-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00619 CARD Caspase recruitment domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 1cwwA00
2M5VA 2MB9A 4IZ5E 2N97A 2BBRA 2L9MA 2LS7A 4N1KA 1A1WA 2DO9A 4RHWE 1C15A 3MOPG 4RHWA 2YGSA 2VGQA 2BBZA 4F42A 2HM2Q 1WMGA 1E3YA 2N80A 3EZQB 2NAQA 2NZ7A 4A2WA 2G7RA 1CWWA 2MS8A 2YU0A 3KATA 2DBHA 1UCPA 4LWDA 2DBDA 4P4HA 2N83A 1DGNA 4E9MA 4ZBWA 4O6XA 3T6PA 4P4HI 4UZ0A 4N1JA 4F44A 3LQRA 4NQKA 2B1WA 3YGSC 4O9FA 2KN6A 2N00A 2OF5H 2L6AA 2NSNA 2YQFA 2MPCA 1D2ZB 3MOPK 3CRDA 2MS7A 1DDFA 2P1HA 2LWEA 4JUPA 1NGRA 3MOPA 4M9ZA 2GF5A 4M9XA 2DBFA 1FADA 4I16A 2IB1A 2KM6A 2LWDA 2O71A 2F1SA 2A5YB 3LQQA 4IZAB 4JQWA 2OF5A 4FH0A 1PN5A 1CY5A 4IZ7B 4EWIA 4M9SA 2N1FA 1WH4A 2N7ZA 4QOBA 1WXPA 2DBGA 3EZQA 4O7QA 2D96A 1E41A 4DWNA 1Z6TA 1YGOA 3CL3A 1D2ZA 4O9LA 1ICHA 4N1LA 3J6JA 4D8OA 2YVIA 1A1ZA 3YGSP 3QF2A 1N3KA 4A2QA 3J63A 2MN4A 2A9IA
chains in the Genus database with same CATH superfamily
2M5VA 2MB9A 4IZ5E 2N97A 2BBRA 2L9MA 2LS7A 4N1KA 1A1WA 2DO9A 4RHWE 1C15A 3MOPG 4RHWA 2YGSA 2VGQA 2BBZA 4F42A 2HM2Q 1WMGA 1E3YA 2N80A 2XV9A 3EZQB 2NAQA 2NZ7A 4A2WA 2G7RA 1CWWA 2MS8A 2YU0A 3KATA 2DBHA 1UCPA 4LWDA 2DBDA 4P4HA 2N83A 1DGNA 4E9MA 4ZBWA 4O6XA 3T6PA 4P4HI 4UZ0A 4N1JA 4F44A 3LQRA 4NQKA 2B1WA 3YGSC 4O9FA 2KN6A 2N00A 2OF5H 2L6AA 2NSNA 2YQFA 2MPCA 1D2ZB 3MOPK 3CRDA 2MS7A 1DDFA 2P1HA 2LWEA 4JUPA 1NGRA 3MOPA 4M9ZA 2GF5A 4M9XA 2DBFA 1FADA 4I16A 2IB1A 2KM6A 2LWDA 2O71A 2F1SA 2A5YB 3LQQA 4IZAB 4JQWA 2OF5A 4FH0A 1PN5A 1CY5A 4IZ7B 4EWIA 4M9SA 2N1FA 1WH4A 2N7ZA 4QOBA 1WXPA 2DBGA 3EZQA 4O7QA 2D96A 1E41A 4DWNA 1Z6TA 1YGOA 3CL3A 1D2ZA 4O9LA 1ICHA 4N1LA 3J6JA 4D8OA 2YVIA 1A1ZA 3YGSP 3QF2A 1N3KA 4A2QA 3J63A 2MN4A 2A9IA 2MJMA
chains in the Genus database with same CATH topology
2M5VA 2MB9A 4IZ5E 2N97A 2BBRA 2L9MA 2LS7A 4N1KA 1A1WA 2DO9A 4RHWE 1C15A 3MOPG 4RHWA 2YGSA 2VGQA 2BBZA 4F42A 2HM2Q 1WMGA 1E3YA 2N80A 2XV9A 3EZQB 2NAQA 2NZ7A 4A2WA 2G7RA 1CWWA 2MS8A 2YU0A 3KATA 2DBHA 1UCPA 4LWDA 2DBDA 4P4HA 2N83A 1DGNA 4E9MA 4ZBWA 4O6XA 3T6PA 4P4HI 4UZ0A 4N1JA 4F44A 3LQRA 4NQKA 2B1WA 3YGSC 4O9FA 2KN6A 2N00A 2OF5H 2L6AA 2NSNA 2YQFA 2MPCA 1D2ZB 3MOPK 3CRDA 2MS7A 1DDFA 2P1HA 2LWEA 4JUPA 1NGRA 3MOPA 4M9ZA 2GF5A 4M9XA 2DBFA 1FADA 4I16A 2IB1A 2KM6A 2LWDA 2O71A 2F1SA 2A5YB 3LQQA 4IZAB 4JQWA 2OF5A 4FH0A 1PN5A 1CY5A 4IZ7B 4EWIA 4M9SA 2N1FA 1WH4A 2N7ZA 4QOBA 1WXPA 2DBGA 3EZQA 4O7QA 2D96A 1E41A 4DWNA 1Z6TA 1YGOA 3CL3A 1D2ZA 4O9LA 1ICHA 4N1LA 3J6JA 4D8OA 2YVIA 1A1ZA 3YGSP 3QF2A 1N3KA 4A2QA 3J63A 2MN4A 2A9IA 2MJMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2M5V A;  2MB9 A;  4IZ5 E;  2N97 A;  2BBR A;  2L9M A;  2LS7 A;  4N1K A;  1A1W A;  2DO9 A;  4RHW E;  1C15 A;  3MOP G;  4RHW A;  2YGS A;  2VGQ A;  2BBZ A;  4F42 A;  2HM2 Q;  1WMG A;  1E3Y A;  2N80 A;  3EZQ B;  2NAQ A;  2NZ7 A;  4A2W A;  2G7R A;  1CWW A;  2MS8 A;  2YU0 A;  3KAT A;  2DBH A;  1UCP A;  4LWD A;  2DBD A;  4P4H A;  2N83 A;  1DGN A;  4E9M A;  4ZBW A;  4O6X A;  3T6P A;  4P4H I;  4UZ0 A;  4N1J A;  4F44 A;  3LQR A;  4NQK A;  2B1W A;  3YGS C;  4O9F A;  2KN6 A;  2N00 A;  2OF5 H;  2L6A A;  2NSN A;  2YQF A;  2MPC A;  1D2Z B;  3MOP K;  3CRD A;  2MS7 A;  1DDF A;  2P1H A;  2LWE A;  4JUP A;  1NGR A;  3MOP A;  4M9Z A;  2GF5 A;  4M9X A;  2DBF A;  1FAD A;  4I16 A;  2IB1 A;  2KM6 A;  2LWD A;  2O71 A;  2F1S A;  2A5Y B;  3LQQ A;  4IZA B;  4JQW A;  2OF5 A;  4FH0 A;  1PN5 A;  1CY5 A;  4IZ7 B;  4EWI A;  4M9S A;  2N1F A;  1WH4 A;  2N7Z A;  4QOB A;  1WXP A;  2DBG A;  3EZQ A;  4O7Q A;  2D96 A;  1E41 A;  4DWN A;  1Z6T A;  1YGO A;  3CL3 A;  1D2Z A;  4O9L A;  1ICH A;  4N1L A;  3J6J A;  4D8O A;  2YVI A;  1A1Z A;  3YGS P;  3QF2 A;  1N3K A;  4A2Q A;  3J63 A;  2MN4 A;  2A9I A; 
#chains in the Genus database with same CATH topology
 2M5V A;  2MB9 A;  4IZ5 E;  2N97 A;  2BBR A;  2L9M A;  2LS7 A;  4N1K A;  1A1W A;  2DO9 A;  4RHW E;  1C15 A;  3MOP G;  4RHW A;  2YGS A;  2VGQ A;  2BBZ A;  4F42 A;  2HM2 Q;  1WMG A;  1E3Y A;  2N80 A;  2XV9 A;  3EZQ B;  2NAQ A;  2NZ7 A;  4A2W A;  2G7R A;  1CWW A;  2MS8 A;  2YU0 A;  3KAT A;  2DBH A;  1UCP A;  4LWD A;  2DBD A;  4P4H A;  2N83 A;  1DGN A;  4E9M A;  4ZBW A;  4O6X A;  3T6P A;  4P4H I;  4UZ0 A;  4N1J A;  4F44 A;  3LQR A;  4NQK A;  2B1W A;  3YGS C;  4O9F A;  2KN6 A;  2N00 A;  2OF5 H;  2L6A A;  2NSN A;  2YQF A;  2MPC A;  1D2Z B;  3MOP K;  3CRD A;  2MS7 A;  1DDF A;  2P1H A;  2LWE A;  4JUP A;  1NGR A;  3MOP A;  4M9Z A;  2GF5 A;  4M9X A;  2DBF A;  1FAD A;  4I16 A;  2IB1 A;  2KM6 A;  2LWD A;  2O71 A;  2F1S A;  2A5Y B;  3LQQ A;  4IZA B;  4JQW A;  2OF5 A;  4FH0 A;  1PN5 A;  1CY5 A;  4IZ7 B;  4EWI A;  4M9S A;  2N1F A;  1WH4 A;  2N7Z A;  4QOB A;  1WXP A;  2DBG A;  3EZQ A;  4O7Q A;  2D96 A;  1E41 A;  4DWN A;  1Z6T A;  1YGO A;  3CL3 A;  1D2Z A;  4O9L A;  1ICH A;  4N1L A;  3J6J A;  4D8O A;  2YVI A;  1A1Z A;  3YGS P;  3QF2 A;  1N3K A;  4A2Q A;  3J63 A;  2MN4 A;  2A9I A;  2MJM A; 
#chains in the Genus database with same CATH homology
 2M5V A;  2MB9 A;  4IZ5 E;  2N97 A;  2BBR A;  2L9M A;  2LS7 A;  4N1K A;  1A1W A;  2DO9 A;  4RHW E;  1C15 A;  3MOP G;  4RHW A;  2YGS A;  2VGQ A;  2BBZ A;  4F42 A;  2HM2 Q;  1WMG A;  1E3Y A;  2N80 A;  2XV9 A;  3EZQ B;  2NAQ A;  2NZ7 A;  4A2W A;  2G7R A;  1CWW A;  2MS8 A;  2YU0 A;  3KAT A;  2DBH A;  1UCP A;  4LWD A;  2DBD A;  4P4H A;  2N83 A;  1DGN A;  4E9M A;  4ZBW A;  4O6X A;  3T6P A;  4P4H I;  4UZ0 A;  4N1J A;  4F44 A;  3LQR A;  4NQK A;  2B1W A;  3YGS C;  4O9F A;  2KN6 A;  2N00 A;  2OF5 H;  2L6A A;  2NSN A;  2YQF A;  2MPC A;  1D2Z B;  3MOP K;  3CRD A;  2MS7 A;  1DDF A;  2P1H A;  2LWE A;  4JUP A;  1NGR A;  3MOP A;  4M9Z A;  2GF5 A;  4M9X A;  2DBF A;  1FAD A;  4I16 A;  2IB1 A;  2KM6 A;  2LWD A;  2O71 A;  2F1S A;  2A5Y B;  3LQQ A;  4IZA B;  4JQW A;  2OF5 A;  4FH0 A;  1PN5 A;  1CY5 A;  4IZ7 B;  4EWI A;  4M9S A;  2N1F A;  1WH4 A;  2N7Z A;  4QOB A;  1WXP A;  2DBG A;  3EZQ A;  4O7Q A;  2D96 A;  1E41 A;  4DWN A;  1Z6T A;  1YGO A;  3CL3 A;  1D2Z A;  4O9L A;  1ICH A;  4N1L A;  3J6J A;  4D8O A;  2YVI A;  1A1Z A;  3YGS P;  3QF2 A;  1N3K A;  4A2Q A;  3J63 A;  2MN4 A;  2A9I A;  2MJM A; 
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similar chains in the pdb database (?% sequence similarity)

 
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