1CWWA

Solution structure of the caspase recruitment domain (card) from apaf-1
Total Genus 31
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
31
sequence length
102
structure length
102
Chain Sequence
GPLGSMDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1.
pubmed doi rcsb
molecule tags Apoptosis
source organism Homo sapiens
molecule keywords APOPTOTIC PROTEASE ACTIVATING FACTOR 1
total genus 31
structure length 102
sequence length 102
ec nomenclature
pdb deposition date 1999-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00619 CARD Caspase recruitment domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 1cwwA00
2LWEA 4I16A 4RHWA 4QOBA 2DBGA 3CL3A 4F44A 2L9MA 4O6XA 2MN4A 2DO9A 4E9MA 2G7RA 1WXPA 2KM6A 1DGNA 1WH4A 2DBFA 3YGSC 4O7QA 1D2ZB 2A9IA 1D2ZA 2LWDA 2DBHA 3MOPA 1CY5A 3EZQA 2YVIA 2N1FA 4NQKA 4IZ7B 4F42A 2BBRA 2GF5A 1Z6TA 2O71A 1DDFA 2IB1A 3T6PA 2N80A 1C15A 3YGSP 2MPCA 2OF5A 3CRDA 1PN5A 2NSNA 4IZAB 3QF2A 2A5YB 4JQWA 4P4HI 1UCPA 4M9ZA 2P1HA 4O9FA 2YU0A 2MB9A 4A2QA 2MS7A 3KATA 2F1SA 1E3YA 2VGQA 1YGOA 1ICHA 2HM2Q 4IZ5E 4M9SA 3J63A 2NAQA 4LWDA 2OF5H 1WMGA 2B1WA 2YGSA 4JUPA 1N3KA 3MOPG 4UZ0A 2N7ZA 4FH0A 2LS7A 2N97A 3LQRA 1E41A 2YQFA 3LQQA 4D8OA 4RHWE 2D96A 4N1LA 1A1WA 4N1KA 4O9LA 4ZBWA 1FADA 4A2WA 4EWIA 2N83A 2KN6A 4DWNA 4P4HA 2L6AA 2N00A 4N1JA 3EZQB 2DBDA 1CWWA 1NGRA 3MOPK 2MS8A 2M5VA 1A1ZA 3J6JA 4M9XA 2NZ7A 2BBZA
chains in the Genus database with same CATH superfamily
2LWEA 4I16A 4RHWA 4QOBA 2DBGA 3CL3A 4F44A 2L9MA 4O6XA 2MN4A 2DO9A 4E9MA 2G7RA 1WXPA 2KM6A 1DGNA 1WH4A 2DBFA 3YGSC 4O7QA 1D2ZB 2A9IA 1D2ZA 2LWDA 2DBHA 3MOPA 1CY5A 3EZQA 2YVIA 2N1FA 4NQKA 4IZ7B 4F42A 2BBRA 2GF5A 1Z6TA 2O71A 1DDFA 2IB1A 3T6PA 2N80A 1C15A 3YGSP 2MPCA 2OF5A 3CRDA 1PN5A 2NSNA 4IZAB 3QF2A 2A5YB 4JQWA 4P4HI 1UCPA 4M9ZA 2P1HA 4O9FA 2XV9A 2YU0A 2MB9A 4A2QA 2MS7A 3KATA 2F1SA 1E3YA 2VGQA 1YGOA 1ICHA 2HM2Q 4IZ5E 4M9SA 3J63A 2NAQA 4LWDA 2OF5H 1WMGA 2B1WA 2YGSA 4JUPA 1N3KA 3MOPG 4UZ0A 2N7ZA 4FH0A 2LS7A 2N97A 3LQRA 1E41A 2YQFA 3LQQA 4D8OA 2MJMA 4RHWE 2D96A 4N1LA 1A1WA 4N1KA 4O9LA 4ZBWA 1FADA 4A2WA 4EWIA 2N83A 2KN6A 4DWNA 4P4HA 2L6AA 2N00A 4N1JA 3EZQB 2DBDA 1CWWA 1NGRA 3MOPK 2MS8A 2M5VA 1A1ZA 3J6JA 4M9XA 2NZ7A 2BBZA
chains in the Genus database with same CATH topology
2LWEA 4I16A 4RHWA 4QOBA 2DBGA 3CL3A 4F44A 2L9MA 4O6XA 2MN4A 2DO9A 4E9MA 2G7RA 1WXPA 2KM6A 1DGNA 1WH4A 2DBFA 3YGSC 4O7QA 1D2ZB 2A9IA 1D2ZA 2LWDA 2DBHA 3MOPA 1CY5A 3EZQA 2YVIA 2N1FA 4NQKA 4IZ7B 4F42A 2BBRA 2GF5A 1Z6TA 2O71A 1DDFA 2IB1A 3T6PA 2N80A 1C15A 3YGSP 2MPCA 2OF5A 3CRDA 1PN5A 2NSNA 4IZAB 3QF2A 2A5YB 4JQWA 4P4HI 1UCPA 4M9ZA 2P1HA 4O9FA 2XV9A 2YU0A 2MB9A 4A2QA 2MS7A 3KATA 2F1SA 1E3YA 2VGQA 1YGOA 1ICHA 2HM2Q 4IZ5E 4M9SA 3J63A 2NAQA 4LWDA 2OF5H 1WMGA 2B1WA 2YGSA 4JUPA 1N3KA 3MOPG 4UZ0A 2N7ZA 4FH0A 2LS7A 2N97A 3LQRA 1E41A 2YQFA 3LQQA 4D8OA 2MJMA 4RHWE 2D96A 4N1LA 1A1WA 4N1KA 4O9LA 4ZBWA 1FADA 4A2WA 4EWIA 2N83A 2KN6A 4DWNA 4P4HA 2L6AA 2N00A 4N1JA 3EZQB 2DBDA 1CWWA 1NGRA 3MOPK 2MS8A 2M5VA 1A1ZA 3J6JA 4M9XA 2NZ7A 2BBZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2LWE A;  4I16 A;  4RHW A;  4QOB A;  2DBG A;  3CL3 A;  4F44 A;  2L9M A;  4O6X A;  2MN4 A;  2DO9 A;  4E9M A;  2G7R A;  1WXP A;  2KM6 A;  1DGN A;  1WH4 A;  2DBF A;  3YGS C;  4O7Q A;  1D2Z B;  2A9I A;  1D2Z A;  2LWD A;  2DBH A;  3MOP A;  1CY5 A;  3EZQ A;  2YVI A;  2N1F A;  4NQK A;  4IZ7 B;  4F42 A;  2BBR A;  2GF5 A;  1Z6T A;  2O71 A;  1DDF A;  2IB1 A;  3T6P A;  2N80 A;  1C15 A;  3YGS P;  2MPC A;  2OF5 A;  3CRD A;  1PN5 A;  2NSN A;  4IZA B;  3QF2 A;  2A5Y B;  4JQW A;  4P4H I;  1UCP A;  4M9Z A;  2P1H A;  4O9F A;  2YU0 A;  2MB9 A;  4A2Q A;  2MS7 A;  3KAT A;  2F1S A;  1E3Y A;  2VGQ A;  1YGO A;  1ICH A;  2HM2 Q;  4IZ5 E;  4M9S A;  3J63 A;  2NAQ A;  4LWD A;  2OF5 H;  1WMG A;  2B1W A;  2YGS A;  4JUP A;  1N3K A;  3MOP G;  4UZ0 A;  2N7Z A;  4FH0 A;  2LS7 A;  2N97 A;  3LQR A;  1E41 A;  2YQF A;  3LQQ A;  4D8O A;  4RHW E;  2D96 A;  4N1L A;  1A1W A;  4N1K A;  4O9L A;  4ZBW A;  1FAD A;  4A2W A;  4EWI A;  2N83 A;  2KN6 A;  4DWN A;  4P4H A;  2L6A A;  2N00 A;  4N1J A;  3EZQ B;  2DBD A;  1CWW A;  1NGR A;  3MOP K;  2MS8 A;  2M5V A;  1A1Z A;  3J6J A;  4M9X A;  2NZ7 A;  2BBZ A; 
#chains in the Genus database with same CATH topology
 2LWE A;  4I16 A;  4RHW A;  4QOB A;  2DBG A;  3CL3 A;  4F44 A;  2L9M A;  4O6X A;  2MN4 A;  2DO9 A;  4E9M A;  2G7R A;  1WXP A;  2KM6 A;  1DGN A;  1WH4 A;  2DBF A;  3YGS C;  4O7Q A;  1D2Z B;  2A9I A;  1D2Z A;  2LWD A;  2DBH A;  3MOP A;  1CY5 A;  3EZQ A;  2YVI A;  2N1F A;  4NQK A;  4IZ7 B;  4F42 A;  2BBR A;  2GF5 A;  1Z6T A;  2O71 A;  1DDF A;  2IB1 A;  3T6P A;  2N80 A;  1C15 A;  3YGS P;  2MPC A;  2OF5 A;  3CRD A;  1PN5 A;  2NSN A;  4IZA B;  3QF2 A;  2A5Y B;  4JQW A;  4P4H I;  1UCP A;  4M9Z A;  2P1H A;  4O9F A;  2XV9 A;  2YU0 A;  2MB9 A;  4A2Q A;  2MS7 A;  3KAT A;  2F1S A;  1E3Y A;  2VGQ A;  1YGO A;  1ICH A;  2HM2 Q;  4IZ5 E;  4M9S A;  3J63 A;  2NAQ A;  4LWD A;  2OF5 H;  1WMG A;  2B1W A;  2YGS A;  4JUP A;  1N3K A;  3MOP G;  4UZ0 A;  2N7Z A;  4FH0 A;  2LS7 A;  2N97 A;  3LQR A;  1E41 A;  2YQF A;  3LQQ A;  4D8O A;  2MJM A;  4RHW E;  2D96 A;  4N1L A;  1A1W A;  4N1K A;  4O9L A;  4ZBW A;  1FAD A;  4A2W A;  4EWI A;  2N83 A;  2KN6 A;  4DWN A;  4P4H A;  2L6A A;  2N00 A;  4N1J A;  3EZQ B;  2DBD A;  1CWW A;  1NGR A;  3MOP K;  2MS8 A;  2M5V A;  1A1Z A;  3J6J A;  4M9X A;  2NZ7 A;  2BBZ A; 
#chains in the Genus database with same CATH homology
 2LWE A;  4I16 A;  4RHW A;  4QOB A;  2DBG A;  3CL3 A;  4F44 A;  2L9M A;  4O6X A;  2MN4 A;  2DO9 A;  4E9M A;  2G7R A;  1WXP A;  2KM6 A;  1DGN A;  1WH4 A;  2DBF A;  3YGS C;  4O7Q A;  1D2Z B;  2A9I A;  1D2Z A;  2LWD A;  2DBH A;  3MOP A;  1CY5 A;  3EZQ A;  2YVI A;  2N1F A;  4NQK A;  4IZ7 B;  4F42 A;  2BBR A;  2GF5 A;  1Z6T A;  2O71 A;  1DDF A;  2IB1 A;  3T6P A;  2N80 A;  1C15 A;  3YGS P;  2MPC A;  2OF5 A;  3CRD A;  1PN5 A;  2NSN A;  4IZA B;  3QF2 A;  2A5Y B;  4JQW A;  4P4H I;  1UCP A;  4M9Z A;  2P1H A;  4O9F A;  2XV9 A;  2YU0 A;  2MB9 A;  4A2Q A;  2MS7 A;  3KAT A;  2F1S A;  1E3Y A;  2VGQ A;  1YGO A;  1ICH A;  2HM2 Q;  4IZ5 E;  4M9S A;  3J63 A;  2NAQ A;  4LWD A;  2OF5 H;  1WMG A;  2B1W A;  2YGS A;  4JUP A;  1N3K A;  3MOP G;  4UZ0 A;  2N7Z A;  4FH0 A;  2LS7 A;  2N97 A;  3LQR A;  1E41 A;  2YQF A;  3LQQ A;  4D8O A;  2MJM A;  4RHW E;  2D96 A;  4N1L A;  1A1W A;  4N1K A;  4O9L A;  4ZBW A;  1FAD A;  4A2W A;  4EWI A;  2N83 A;  2KN6 A;  4DWN A;  4P4H A;  2L6A A;  2N00 A;  4N1J A;  3EZQ B;  2DBD A;  1CWW A;  1NGR A;  3MOP K;  2MS8 A;  2M5V A;  1A1Z A;  3J6J A;  4M9X A;  2NZ7 A;  2BBZ A; 
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similar chains in the pdb database (?% sequence similarity)

 
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