1CWWA

Solution structure of the caspase recruitment domain (card) from apaf-1
Total Genus 31
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
31
sequence length
102
structure length
102
Chain Sequence
GPLGSMDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Apoptosis
molecule keywords APOPTOTIC PROTEASE ACTIVATING FACTOR 1
total genus 31
structure length 102
sequence length 102
ec nomenclature
pdb deposition date 1999-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00619 CARD Caspase recruitment domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 1cwwA00
3CRDA 4LWDA 4O9LA 3MOPA 3T6PA 2A5YB 2LWDA 3MOPG 3J6JA 2KN6A 3J63A 2A9IA 4RHWE 4F42A 4N1LA 2M5VA 1A1ZA 3KATA 4DWNA 1E41A 2YGSA 2MN4A 2YQFA 3EZQB 4IZ5E 3EZQA 1WMGA 2D96A 1CWWA 2L9MA 2DBFA 2L6AA 2P1HA 2YVIA 1E3YA 1ICHA 2DO9A 1NGRA 4A2WA 2GF5A 2MS8A 2N7ZA 1FADA 4JUPA 4ZBWA 4E9MA 4F44A 1N3KA 2IB1A 2YU0A 4A2QA 4O6XA 1A1WA 3QF2A 4M9ZA 3YGSC 4M9SA 4I16A 2MB9A 1WH4A 2KM6A 1Z6TA 4N1KA 2N97A 2VGQA 2HM2Q 2BBRA 4FH0A 1PN5A 4M9XA 2OF5H 1C15A 4O9FA 4IZAB 3MOPK 2OF5A 4N1JA 2NZ7A 4P4HA 4NQKA 3CL3A 2DBGA 2MS7A 3LQRA 2O71A 4UZ0A 2BBZA 4JQWA 2DBHA 2G7RA 2NSNA 4QOBA 1DDFA 1YGOA 2N00A 1D2ZB 4IZ7B 1DGNA 2N80A 1D2ZA 2N83A 2DBDA 3YGSP 2LWEA 2MPCA 2NAQA 4P4HI 1CY5A 2LS7A 4D8OA 2N1FA 3LQQA 4EWIA 1WXPA 2B1WA 4O7QA 4RHWA 1UCPA 2F1SA
chains in the Genus database with same CATH superfamily
3CRDA 4LWDA 4O9LA 3MOPA 3T6PA 2A5YB 2LWDA 3MOPG 2XV9A 3J6JA 2KN6A 3J63A 2A9IA 4RHWE 4F42A 4N1LA 2M5VA 1A1ZA 3KATA 4DWNA 1E41A 2YGSA 2MN4A 2YQFA 3EZQB 4IZ5E 3EZQA 1WMGA 2D96A 1CWWA 2L9MA 2DBFA 2L6AA 2P1HA 2YVIA 1E3YA 1ICHA 2DO9A 1NGRA 4A2WA 2GF5A 2MS8A 2N7ZA 1FADA 4JUPA 4ZBWA 4E9MA 4F44A 1N3KA 2IB1A 2YU0A 4A2QA 2MJMA 4O6XA 1A1WA 3QF2A 4M9ZA 3YGSC 4M9SA 4I16A 2MB9A 1WH4A 2KM6A 1Z6TA 4N1KA 2N97A 2VGQA 2HM2Q 2BBRA 4FH0A 1PN5A 4M9XA 2OF5H 1C15A 4O9FA 4IZAB 3MOPK 2OF5A 4N1JA 2NZ7A 4P4HA 4NQKA 3CL3A 2DBGA 2MS7A 3LQRA 2O71A 4UZ0A 2BBZA 4JQWA 2DBHA 2G7RA 2NSNA 4QOBA 1DDFA 1YGOA 2N00A 1D2ZB 4IZ7B 1DGNA 2N80A 1D2ZA 2N83A 2DBDA 3YGSP 2LWEA 2MPCA 2NAQA 4P4HI 1CY5A 2LS7A 4D8OA 2N1FA 3LQQA 4EWIA 1WXPA 2B1WA 4O7QA 4RHWA 1UCPA 2F1SA
chains in the Genus database with same CATH topology
3CRDA 4LWDA 4O9LA 3MOPA 3T6PA 2A5YB 2LWDA 3MOPG 2XV9A 3J6JA 2KN6A 3J63A 2A9IA 4RHWE 4F42A 4N1LA 2M5VA 1A1ZA 3KATA 4DWNA 1E41A 2YGSA 2MN4A 2YQFA 3EZQB 4IZ5E 3EZQA 1WMGA 2D96A 1CWWA 2L9MA 2DBFA 2L6AA 2P1HA 2YVIA 1E3YA 1ICHA 2DO9A 1NGRA 4A2WA 2GF5A 2MS8A 2N7ZA 1FADA 4JUPA 4ZBWA 4E9MA 4F44A 1N3KA 2IB1A 2YU0A 4A2QA 2MJMA 4O6XA 1A1WA 3QF2A 4M9ZA 3YGSC 4M9SA 4I16A 2MB9A 1WH4A 2KM6A 1Z6TA 4N1KA 2N97A 2VGQA 2HM2Q 2BBRA 4FH0A 1PN5A 4M9XA 2OF5H 1C15A 4O9FA 4IZAB 3MOPK 2OF5A 4N1JA 2NZ7A 4P4HA 4NQKA 3CL3A 2DBGA 2MS7A 3LQRA 2O71A 4UZ0A 2BBZA 4JQWA 2DBHA 2G7RA 2NSNA 4QOBA 1DDFA 1YGOA 2N00A 1D2ZB 4IZ7B 1DGNA 2N80A 1D2ZA 2N83A 2DBDA 3YGSP 2LWEA 2MPCA 2NAQA 4P4HI 1CY5A 2LS7A 4D8OA 2N1FA 3LQQA 4EWIA 1WXPA 2B1WA 4O7QA 4RHWA 1UCPA 2F1SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CRD A;  4LWD A;  4O9L A;  3MOP A;  3T6P A;  2A5Y B;  2LWD A;  3MOP G;  3J6J A;  2KN6 A;  3J63 A;  2A9I A;  4RHW E;  4F42 A;  4N1L A;  2M5V A;  1A1Z A;  3KAT A;  4DWN A;  1E41 A;  2YGS A;  2MN4 A;  2YQF A;  3EZQ B;  4IZ5 E;  3EZQ A;  1WMG A;  2D96 A;  1CWW A;  2L9M A;  2DBF A;  2L6A A;  2P1H A;  2YVI A;  1E3Y A;  1ICH A;  2DO9 A;  1NGR A;  4A2W A;  2GF5 A;  2MS8 A;  2N7Z A;  1FAD A;  4JUP A;  4ZBW A;  4E9M A;  4F44 A;  1N3K A;  2IB1 A;  2YU0 A;  4A2Q A;  4O6X A;  1A1W A;  3QF2 A;  4M9Z A;  3YGS C;  4M9S A;  4I16 A;  2MB9 A;  1WH4 A;  2KM6 A;  1Z6T A;  4N1K A;  2N97 A;  2VGQ A;  2HM2 Q;  2BBR A;  4FH0 A;  1PN5 A;  4M9X A;  2OF5 H;  1C15 A;  4O9F A;  4IZA B;  3MOP K;  2OF5 A;  4N1J A;  2NZ7 A;  4P4H A;  4NQK A;  3CL3 A;  2DBG A;  2MS7 A;  3LQR A;  2O71 A;  4UZ0 A;  2BBZ A;  4JQW A;  2DBH A;  2G7R A;  2NSN A;  4QOB A;  1DDF A;  1YGO A;  2N00 A;  1D2Z B;  4IZ7 B;  1DGN A;  2N80 A;  1D2Z A;  2N83 A;  2DBD A;  3YGS P;  2LWE A;  2MPC A;  2NAQ A;  4P4H I;  1CY5 A;  2LS7 A;  4D8O A;  2N1F A;  3LQQ A;  4EWI A;  1WXP A;  2B1W A;  4O7Q A;  4RHW A;  1UCP A;  2F1S A; 
#chains in the Genus database with same CATH topology
 3CRD A;  4LWD A;  4O9L A;  3MOP A;  3T6P A;  2A5Y B;  2LWD A;  3MOP G;  2XV9 A;  3J6J A;  2KN6 A;  3J63 A;  2A9I A;  4RHW E;  4F42 A;  4N1L A;  2M5V A;  1A1Z A;  3KAT A;  4DWN A;  1E41 A;  2YGS A;  2MN4 A;  2YQF A;  3EZQ B;  4IZ5 E;  3EZQ A;  1WMG A;  2D96 A;  1CWW A;  2L9M A;  2DBF A;  2L6A A;  2P1H A;  2YVI A;  1E3Y A;  1ICH A;  2DO9 A;  1NGR A;  4A2W A;  2GF5 A;  2MS8 A;  2N7Z A;  1FAD A;  4JUP A;  4ZBW A;  4E9M A;  4F44 A;  1N3K A;  2IB1 A;  2YU0 A;  4A2Q A;  2MJM A;  4O6X A;  1A1W A;  3QF2 A;  4M9Z A;  3YGS C;  4M9S A;  4I16 A;  2MB9 A;  1WH4 A;  2KM6 A;  1Z6T A;  4N1K A;  2N97 A;  2VGQ A;  2HM2 Q;  2BBR A;  4FH0 A;  1PN5 A;  4M9X A;  2OF5 H;  1C15 A;  4O9F A;  4IZA B;  3MOP K;  2OF5 A;  4N1J A;  2NZ7 A;  4P4H A;  4NQK A;  3CL3 A;  2DBG A;  2MS7 A;  3LQR A;  2O71 A;  4UZ0 A;  2BBZ A;  4JQW A;  2DBH A;  2G7R A;  2NSN A;  4QOB A;  1DDF A;  1YGO A;  2N00 A;  1D2Z B;  4IZ7 B;  1DGN A;  2N80 A;  1D2Z A;  2N83 A;  2DBD A;  3YGS P;  2LWE A;  2MPC A;  2NAQ A;  4P4H I;  1CY5 A;  2LS7 A;  4D8O A;  2N1F A;  3LQQ A;  4EWI A;  1WXP A;  2B1W A;  4O7Q A;  4RHW A;  1UCP A;  2F1S A; 
#chains in the Genus database with same CATH homology
 3CRD A;  4LWD A;  4O9L A;  3MOP A;  3T6P A;  2A5Y B;  2LWD A;  3MOP G;  2XV9 A;  3J6J A;  2KN6 A;  3J63 A;  2A9I A;  4RHW E;  4F42 A;  4N1L A;  2M5V A;  1A1Z A;  3KAT A;  4DWN A;  1E41 A;  2YGS A;  2MN4 A;  2YQF A;  3EZQ B;  4IZ5 E;  3EZQ A;  1WMG A;  2D96 A;  1CWW A;  2L9M A;  2DBF A;  2L6A A;  2P1H A;  2YVI A;  1E3Y A;  1ICH A;  2DO9 A;  1NGR A;  4A2W A;  2GF5 A;  2MS8 A;  2N7Z A;  1FAD A;  4JUP A;  4ZBW A;  4E9M A;  4F44 A;  1N3K A;  2IB1 A;  2YU0 A;  4A2Q A;  2MJM A;  4O6X A;  1A1W A;  3QF2 A;  4M9Z A;  3YGS C;  4M9S A;  4I16 A;  2MB9 A;  1WH4 A;  2KM6 A;  1Z6T A;  4N1K A;  2N97 A;  2VGQ A;  2HM2 Q;  2BBR A;  4FH0 A;  1PN5 A;  4M9X A;  2OF5 H;  1C15 A;  4O9F A;  4IZA B;  3MOP K;  2OF5 A;  4N1J A;  2NZ7 A;  4P4H A;  4NQK A;  3CL3 A;  2DBG A;  2MS7 A;  3LQR A;  2O71 A;  4UZ0 A;  2BBZ A;  4JQW A;  2DBH A;  2G7R A;  2NSN A;  4QOB A;  1DDF A;  1YGO A;  2N00 A;  1D2Z B;  4IZ7 B;  1DGN A;  2N80 A;  1D2Z A;  2N83 A;  2DBD A;  3YGS P;  2LWE A;  2MPC A;  2NAQ A;  4P4H I;  1CY5 A;  2LS7 A;  4D8O A;  2N1F A;  3LQQ A;  4EWI A;  1WXP A;  2B1W A;  4O7Q A;  4RHW A;  1UCP A;  2F1S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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