The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
79
|
sequence length |
315
|
structure length |
307
|
Chain Sequence |
RRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTV
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
publication title |
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.
pubmed doi rcsb |
molecule keywords |
PHOSPHOINOSITIDE PHOSPHATASE PTEN
|
molecule tags |
Hydrolase
|
source organism |
Homo sapiens
|
total genus |
79
|
structure length |
307
|
sequence length |
315
|
ec nomenclature |
ec
3.1.3.16: Protein-serine/threonine phosphatase. |
pdb deposition date | 1999-10-11 |
chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
---|---|---|---|
A | PF00782 | DSPc | Dual specificity phosphatase, catalytic domain |
A | PF10409 | PTEN_C2 | C2 domain of PTEN tumour-suppressor protein |
cath code
| Class | Architecture | Topology | Homology | Domain |
---|---|---|---|---|---|
Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulin-like | ||
Alpha Beta | Alpha-Beta Complex | Protein-Tyrosine Phosphatase; Chain A | Protein tyrosine phosphatase superfamily |