1DM5A

Annexin xii e105k homohexamer crystal structure
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
315
structure length
315
Chain Sequence
VVQGTVKPHASFNSREDAETLRKAMKGIGTDEKSITHILATRSNAQRQQIKTDYTTLFGKHLEDELKSELSGNYEAAALALLRKPDEFLAEQLHAAMKGLGTDKNALIDILCTQSNAQIHAIKAAFKLLYKEDLEKEIISETSGNFQRLLVSMLQGGRKEDEPVNAAHAAEDAAAIYQAGEGQIGTDESRFNAVLATRSYPQLHQIFHEYSKISNKTILQAIENEFSGDIKNGLLAIVKSVENRFAYFAERLHHAMKGLGTSDKTLIRILVSRSEIDLANIKETFQAMYGKSLYEFIADDCSGDYKDLLLQITGH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ANNEXIN XII E105K MUTANT HOMOHEXAMER
publication title Annexin XII E105K crystal structure: identification of a pH-dependent switch for mutant hexamerization.
pubmed doi rcsb
source organism Hydra vulgaris
molecule tags Unknown function
total genus 128
structure length 315
sequence length 315
chains with identical sequence B, C, D, E, F
ec nomenclature
pdb deposition date 1999-12-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1dm5A01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1dm5A04
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1dm5A02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1dm5A03
1N42A 2H0MA 1HVGA 1ANNA 1AXNA 2IE6A 1AIIA 2Q4CA 2ZHIA 1DM5A 1DK5A 1ANWA 1W7BA 2HYWA 1HM6A 1AEIA 2II2A 1BO9A 2ZHJA 1AOWA 1N00A 2HYUA 2IICA 1ALAA 1W3WA 1N44A 2H0LA 1YCNA 2RANA 1I4AA 1HAKA 1SAVA 1HVDA 1W45A 1AVRA 1G5NA 1YJ0A 4EVFA 1ANXA 1BCYA 1AVCA 1XJLA 1BC0A 1BCWA 1BCZA 4HREA 1YIIA 1HVEA 4EVHA 2ZOCA 4X9PA 3BRXA 2H0KA 1BC1A 1MCXA 1A8BA 2IE7A 2XO2A 4MDUA 1A8AA 4MDVA 1N41A 1AVHA 1BC3A 1HVFA 2XO3A 2HYVA 1M9IA
chains in the Genus database with same CATH superfamily
3SOHB 1N42A 1QC7A 1ANNA 4KN4X 2IE6A 4KMUX 3TW5A 3USYA 4Z21A 1ANWA 2R09A 3ABQA 4EVFA 4A4PA 1ANXA 2QEZA 4HREA 1YIIA 1XSZA 2K6XA 2HSNA 3AO0A 3ANYA 1AVHA 2OY9A 2HYWA 1RE0B 4JXHA 1UPTB 4JK1X 1AIIA 4OIYA 1KU1A 2Q4CA 1DM5A 1DK5A 2HYUA 1R8SE 3AJCA 1I4AA 4Q2SA 1HVDA 4JMOA 1AVRA 1XT0B 1YJ0A 1BCYA 1S9DE 1YGMA 4EVHA 4FHRB 3LTLA 3USWA 1A8BA 2IE7A 2XO2A 4MDUA 4MDVA 1N41A 1BC3A 2XO3A 1M9IA 3ABRA 1AXNA 4JWLA 1HM6A 1AEIA 1N00A 1ALAA 1N44A 2H0LA 1HAKA 4FQ0C 1LKVX 1W45A 1G5NA 1C1KA 3SWVA 1BC0A 1BCWA 1BCZA 4KN7X 1HVEA 1R8QE 3BRXA 1R4AE 2R0DA 2H0KA 4L5MA 4C0AA 3HJLA 1A8AA 1Q8DA 2H0MA 1HVGA 1PBVA 3ABOA 2ZHIA 1W7BA 2II2A 1BO9A 2ZHJA 1AOWA 2IICA 2RANA 1W3WA 1YCNA 1SAVA 3L8NA 1AVCA 3ABSA 1XJLA 4JMIA 1R8ME 2ZOCA 4X9PA 1BC9A 4C7PA 1BC1A 4D7RA 1MCXA 4D7QA 2VXGA 1HVFA 2HYVA
chains in the Genus database with same CATH topology
1N42A 2H0MA 1HVGA 1ANNA 1AXNA 2IE6A 1AIIA 2Q4CA 2ZHIA 1DM5A 1DK5A 1ANWA 1W7BA 2HYWA 1HM6A 1AEIA 2II2A 1BO9A 2ZHJA 1AOWA 1N00A 2HYUA 2IICA 1ALAA 1W3WA 1N44A 2H0LA 1YCNA 2RANA 1I4AA 1HAKA 1SAVA 1HVDA 1W45A 1AVRA 1G5NA 1YJ0A 4EVFA 1ANXA 1BCYA 1AVCA 1XJLA 1BC0A 1BCWA 1BCZA 4HREA 1YIIA 1HVEA 4EVHA 2ZOCA 4X9PA 3BRXA 2H0KA 1BC1A 1MCXA 1A8BA 2IE7A 2XO2A 4MDUA 1A8AA 4MDVA 1N41A 1AVHA 1BC3A 1HVFA 2XO3A 2HYVA 1M9IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1N42 A;  2H0M A;  1HVG A;  1ANN A;  1AXN A;  2IE6 A;  1AII A;  2Q4C A;  2ZHI A;  1DM5 A;  1DK5 A;  1ANW A;  1W7B A;  2HYW A;  1HM6 A;  1AEI A;  2II2 A;  1BO9 A;  2ZHJ A;  1AOW A;  1N00 A;  2HYU A;  2IIC A;  1ALA A;  1W3W A;  1N44 A;  2H0L A;  1YCN A;  2RAN A;  1I4A A;  1HAK A;  1SAV A;  1HVD A;  1W45 A;  1AVR A;  1G5N A;  1YJ0 A;  4EVF A;  1ANX A;  1BCY A;  1AVC A;  1XJL A;  1BC0 A;  1BCW A;  1BCZ A;  4HRE A;  1YII A;  1HVE A;  4EVH A;  2ZOC A;  4X9P A;  3BRX A;  2H0K A;  1BC1 A;  1MCX A;  1A8B A;  2IE7 A;  2XO2 A;  4MDU A;  1A8A A;  4MDV A;  1N41 A;  1AVH A;  1BC3 A;  1HVF A;  2XO3 A;  2HYV A;  1M9I A; 
#chains in the Genus database with same CATH topology
 3SOH B;  1N42 A;  1QC7 A;  1ANN A;  4KN4 X;  2IE6 A;  4KMU X;  3TW5 A;  3USY A;  4Z21 A;  1ANW A;  2R09 A;  3ABQ A;  4EVF A;  4A4P A;  1ANX A;  2QEZ A;  4HRE A;  1YII A;  1XSZ A;  2K6X A;  2HSN A;  3AO0 A;  3ANY A;  1AVH A;  2OY9 A;  2HYW A;  1RE0 B;  4JXH A;  1UPT B;  4JK1 X;  1AII A;  4OIY A;  1KU1 A;  2Q4C A;  1DM5 A;  1DK5 A;  2HYU A;  1R8S E;  3AJC A;  1I4A A;  4Q2S A;  1HVD A;  4JMO A;  1AVR A;  1XT0 B;  1YJ0 A;  1BCY A;  1S9D E;  1YGM A;  4EVH A;  4FHR B;  3LTL A;  3USW A;  1A8B A;  2IE7 A;  2XO2 A;  4MDU A;  4MDV A;  1N41 A;  1BC3 A;  2XO3 A;  1M9I A;  3ABR A;  1AXN A;  4JWL A;  1HM6 A;  1AEI A;  1N00 A;  1ALA A;  1N44 A;  2H0L A;  1HAK A;  4FQ0 C;  1LKV X;  1W45 A;  1G5N A;  1C1K A;  3SWV A;  1BC0 A;  1BCW A;  1BCZ A;  4KN7 X;  1HVE A;  1R8Q E;  3BRX A;  1R4A E;  2R0D A;  2H0K A;  4L5M A;  4C0A A;  3HJL A;  1A8A A;  1Q8D A;  2H0M A;  1HVG A;  1PBV A;  3ABO A;  2ZHI A;  1W7B A;  2II2 A;  1BO9 A;  2ZHJ A;  1AOW A;  2IIC A;  2RAN A;  1W3W A;  1YCN A;  1SAV A;  3L8N A;  1AVC A;  3ABS A;  1XJL A;  4JMI A;  1R8M E;  2ZOC A;  4X9P A;  1BC9 A;  4C7P A;  1BC1 A;  4D7R A;  1MCX A;  4D7Q A;  2VXG A;  1HVF A;  2HYV A; 
#chains in the Genus database with same CATH homology
 1N42 A;  2H0M A;  1HVG A;  1ANN A;  1AXN A;  2IE6 A;  1AII A;  2Q4C A;  2ZHI A;  1DM5 A;  1DK5 A;  1ANW A;  1W7B A;  2HYW A;  1HM6 A;  1AEI A;  2II2 A;  1BO9 A;  2ZHJ A;  1AOW A;  1N00 A;  2HYU A;  2IIC A;  1ALA A;  1W3W A;  1N44 A;  2H0L A;  1YCN A;  2RAN A;  1I4A A;  1HAK A;  1SAV A;  1HVD A;  1W45 A;  1AVR A;  1G5N A;  1YJ0 A;  4EVF A;  1ANX A;  1BCY A;  1AVC A;  1XJL A;  1BC0 A;  1BCW A;  1BCZ A;  4HRE A;  1YII A;  1HVE A;  4EVH A;  2ZOC A;  4X9P A;  3BRX A;  2H0K A;  1BC1 A;  1MCX A;  1A8B A;  2IE7 A;  2XO2 A;  4MDU A;  1A8A A;  4MDV A;  1N41 A;  1AVH A;  1BC3 A;  1HVF A;  2XO3 A;  2HYV A;  1M9I A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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