1ED8A

Structure of e. coli alkaline phosphatase inhibited by the inorganic phosphate at 1.75a resolution
Total Genus 166
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
166
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A revised mechanism for the alkaline phosphatase reaction involving three metal ions.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
total genus 166
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-01-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ed8A00
5L0EA 1SHNA 1KH9A 1KH7A 1Y7AA 1EW9A 2W8SA 1KHKA 5DLVA 4UPHA 4ZGAA 5DLTA 5K4PA 2RH6A 1AJAA 1ELYA 4KM4A 4UPKA 2QZUA 3MK1A 2W5WA 5INHA 3E2DA 3NKQA 3A52A 5LRMA 1N2LA 1ZEDA 3M8ZA 2XR9A 3MK2A 3NKMA 2D1GA 3IDDA 2XRGA 3M8WA 4MHXA 5GOVA 5LQQA 3DPCA 4GTZA 2GLQA 3SZZA 4LRAA 1E2SP 1ZEBA 5L0BA 1EW2A 1FSUA 3OT9A 5IJSA 2ANHA 4GTWA 3TWZA 5GRRA 3UNYA 3SZYA 3BDGB 3DYCA 1KHJA 3Q3QA 4KJDA 1K7HA 4UPLA 1ELZA 4LR9A 5L0KA 1KHNA 4ZG9A 1EQJA 5LIAA 1E33P 2W5XA 3B5QA 3WAVA 2W5QA 5AJ9A 1ALHA 4FDIA 4ZG6A 2GA3A 4CXKA 4GTXA 1URAA 1URBA 3IGZB 3M8YA 3MK0A 4GTYA 1B8JA 4NWXA 4LRCA 4CXSA 4MIVA 1AUKA 2W8DA 1AJCA 1KH4A 4LRFA 1ANIA 4UORA 4FDJA 4LR8A 3T02A 1AJBA 3TX0A 1ZEFA 1ALKA 3WAXA 1N2KA 2GSNA 2ZKTA 3UN2A 3NKNA 5EGEA 4LRBA 1ED9A 4QAXA 4UOPA 3NKPA 2IUCB 3BDFA 2W5VA 5HRTA 4LRDA 4UOOA 1EJJA 4KAVA 3M7VA 3WBHA 3NKRA 4MY4A 3UN5A 2G9YA 3KD8A 3T00A 2W5SA 1ELXA 5TJ3A 1ED8A 2GSUA 4LR7A 5KXAA 3IGYB 2X98A 1HQAA 4LQYA 5IJQA 3WAYA 1EW8A 4CXUA 3CMRA 3TG0A 4KJGA 3T01A 1ALIA 4LR2A 4N7TA 4CYSA 4NWJA 1E3CP 3LXQA 3WAWA 2W5TA 3ED4A 4UPIA 3NVLA 5C66A 1O98A 4B56A 1SHQA 2VQRA 1AJDA 4KAYA 4CYRA 1EI6A 2W5RA 1P49A 1O99A 2IUCA 1KH5A 1KHLA 1HJKA 1ANJA 3BDGA 4TN0A 2GSOA 3NKOA 5EGHA 4LREA 4ZG7A 1E1ZP 1Y6VA 3UO0A 2IFYA 1HDHA 3BDHA 4YR1A 5LRNA 1ALJA 5DLWA 3UN3A
chains in the Genus database with same CATH superfamily
5L0EA 1SHNA 1KH9A 1KH7A 1Y7AA 1EW9A 2W8SA 1KHKA 5DLVA 4UPHA 4ZGAA 5DLTA 5K4PA 2RH6A 1AJAA 1ELYA 4KM4A 4UPKA 2QZUA 3MK1A 2W5WA 5INHA 3E2DA 3NKQA 3A52A 5LRMA 1N2LA 1ZEDA 3M8ZA 2XR9A 3MK2A 3NKMA 2D1GA 3IDDA 2XRGA 3M8WA 4MHXA 5GOVA 5LQQA 3DPCA 4GTZA 2GLQA 3SZZA 4LRAA 1E2SP 1ZEBA 5L0BA 1EW2A 1FSUA 3OT9A 5IJSA 2ANHA 4GTWA 3TWZA 5GRRA 3UNYA 3SZYA 3BDGB 3DYCA 1KHJA 3Q3QA 4KJDA 1K7HA 4UPLA 1ELZA 4LR9A 5L0KA 1KHNA 4ZG9A 1EQJA 5LIAA 1E33P 2W5XA 3B5QA 3WAVA 2W5QA 5AJ9A 1ALHA 4FDIA 4ZG6A 2GA3A 4CXKA 4GTXA 1URAA 1URBA 3IGZB 3M8YA 3MK0A 4GTYA 1B8JA 4NWXA 4LRCA 4CXSA 4MIVA 1AUKA 2W8DA 1AJCA 1KH4A 4LRFA 1ANIA 4UORA 4FDJA 4LR8A 3T02A 1AJBA 3TX0A 1ZEFA 1ALKA 3WAXA 1N2KA 2GSNA 2ZKTA 3UN2A 3NKNA 5EGEA 4LRBA 1ED9A 4QAXA 4UOPA 3NKPA 2IUCB 3BDFA 2W5VA 5HRTA 4LRDA 4UOOA 1EJJA 4KAVA 3M7VA 3WBHA 3NKRA 4MY4A 3UN5A 2G9YA 3KD8A 3T00A 2W5SA 1ELXA 5TJ3A 1ED8A 2GSUA 4LR7A 5KXAA 3IGYB 2X98A 1HQAA 4LQYA 5IJQA 3WAYA 1EW8A 4CXUA 3CMRA 3TG0A 4KJGA 3T01A 1ALIA 4LR2A 4N7TA 4CYSA 4NWJA 1E3CP 3LXQA 3WAWA 2W5TA 3ED4A 4UPIA 3NVLA 5C66A 1O98A 4B56A 1SHQA 2VQRA 1AJDA 4KAYA 4CYRA 1EI6A 2W5RA 1P49A 1O99A 2IUCA 1KH5A 1KHLA 1HJKA 1ANJA 3BDGA 4TN0A 2GSOA 3NKOA 5EGHA 4LREA 4ZG7A 1E1ZP 1Y6VA 3UO0A 2IFYA 1HDHA 3BDHA 4YR1A 5LRNA 1ALJA 5DLWA 3UN3A
chains in the Genus database with same CATH topology
5L0EA 1SHNA 1KH9A 1KH7A 1Y7AA 1EW9A 2W8SA 1KHKA 5DLVA 4UPHA 4ZGAA 5DLTA 5K4PA 2RH6A 1AJAA 1ELYA 4KM4A 4UPKA 2QZUA 3MK1A 2W5WA 5INHA 3E2DA 3NKQA 3A52A 5LRMA 1N2LA 1ZEDA 3M8ZA 2XR9A 3MK2A 3NKMA 2D1GA 3IDDA 2XRGA 3M8WA 4MHXA 5GOVA 5LQQA 3DPCA 4GTZA 2GLQA 3SZZA 4LRAA 1E2SP 1ZEBA 5L0BA 1EW2A 1FSUA 3OT9A 5IJSA 2ANHA 4GTWA 3TWZA 5GRRA 3UNYA 3SZYA 3BDGB 3DYCA 1KHJA 3Q3QA 4KJDA 1K7HA 4UPLA 1ELZA 4LR9A 5L0KA 1KHNA 4ZG9A 1EQJA 5LIAA 1E33P 2W5XA 3B5QA 3WAVA 2W5QA 5AJ9A 1ALHA 4FDIA 4ZG6A 2GA3A 4CXKA 4GTXA 1URAA 1URBA 3IGZB 3M8YA 3MK0A 4GTYA 1B8JA 4NWXA 4LRCA 4CXSA 4MIVA 1AUKA 2W8DA 1AJCA 1KH4A 4LRFA 1ANIA 4UORA 4FDJA 4LR8A 3T02A 1AJBA 3TX0A 1ZEFA 1ALKA 3WAXA 1N2KA 2GSNA 2ZKTA 3UN2A 3NKNA 5EGEA 4LRBA 1ED9A 4QAXA 4UOPA 3NKPA 2IUCB 3BDFA 2W5VA 5HRTA 4LRDA 4UOOA 1EJJA 4KAVA 3M7VA 3WBHA 3NKRA 4MY4A 3UN5A 2G9YA 3KD8A 3T00A 2W5SA 1ELXA 5TJ3A 1ED8A 2GSUA 4LR7A 5KXAA 3IGYB 2X98A 1HQAA 4LQYA 5IJQA 3WAYA 1EW8A 4CXUA 3CMRA 3TG0A 4KJGA 3T01A 1ALIA 4LR2A 4N7TA 4CYSA 4NWJA 1E3CP 3LXQA 3WAWA 2W5TA 3ED4A 4UPIA 3NVLA 5C66A 1O98A 4B56A 1SHQA 2VQRA 1AJDA 4KAYA 4CYRA 1EI6A 2W5RA 1P49A 1O99A 2IUCA 1KH5A 1KHLA 1HJKA 1ANJA 3BDGA 4TN0A 2GSOA 3NKOA 5EGHA 4LREA 4ZG7A 1E1ZP 1Y6VA 3UO0A 2IFYA 1HDHA 3BDHA 4YR1A 5LRNA 1ALJA 5DLWA 3UN3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L0E A;  1SHN A;  1KH9 A;  1KH7 A;  1Y7A A;  1EW9 A;  2W8S A;  1KHK A;  5DLV A;  4UPH A;  4ZGA A;  5DLT A;  5K4P A;  2RH6 A;  1AJA A;  1ELY A;  4KM4 A;  4UPK A;  2QZU A;  3MK1 A;  2W5W A;  5INH A;  3E2D A;  3NKQ A;  3A52 A;  5LRM A;  1N2L A;  1ZED A;  3M8Z A;  2XR9 A;  3MK2 A;  3NKM A;  2D1G A;  3IDD A;  2XRG A;  3M8W A;  4MHX A;  5GOV A;  5LQQ A;  3DPC A;  4GTZ A;  2GLQ A;  3SZZ A;  4LRA A;  1E2S P;  1ZEB A;  5L0B A;  1EW2 A;  1FSU A;  3OT9 A;  5IJS A;  2ANH A;  4GTW A;  3TWZ A;  5GRR A;  3UNY A;  3SZY A;  3BDG B;  3DYC A;  1KHJ A;  3Q3Q A;  4KJD A;  1K7H A;  4UPL A;  1ELZ A;  4LR9 A;  5L0K A;  1KHN A;  4ZG9 A;  1EQJ A;  5LIA A;  1E33 P;  2W5X A;  3B5Q A;  3WAV A;  2W5Q A;  5AJ9 A;  1ALH A;  4FDI A;  4ZG6 A;  2GA3 A;  4CXK A;  4GTX A;  1URA A;  1URB A;  3IGZ B;  3M8Y A;  3MK0 A;  4GTY A;  1B8J A;  4NWX A;  4LRC A;  4CXS A;  4MIV A;  1AUK A;  2W8D A;  1AJC A;  1KH4 A;  4LRF A;  1ANI A;  4UOR A;  4FDJ A;  4LR8 A;  3T02 A;  1AJB A;  3TX0 A;  1ZEF A;  1ALK A;  3WAX A;  1N2K A;  2GSN A;  2ZKT A;  3UN2 A;  3NKN A;  5EGE A;  4LRB A;  1ED9 A;  4QAX A;  4UOP A;  3NKP A;  2IUC B;  3BDF A;  2W5V A;  5HRT A;  4LRD A;  4UOO A;  1EJJ A;  4KAV A;  3M7V A;  3WBH A;  3NKR A;  4MY4 A;  3UN5 A;  2G9Y A;  3KD8 A;  3T00 A;  2W5S A;  1ELX A;  5TJ3 A;  1ED8 A;  2GSU A;  4LR7 A;  5KXA A;  3IGY B;  2X98 A;  1HQA A;  4LQY A;  5IJQ A;  3WAY A;  1EW8 A;  4CXU A;  3CMR A;  3TG0 A;  4KJG A;  3T01 A;  1ALI A;  4LR2 A;  4N7T A;  4CYS A;  4NWJ A;  1E3C P;  3LXQ A;  3WAW A;  2W5T A;  3ED4 A;  4UPI A;  3NVL A;  5C66 A;  1O98 A;  4B56 A;  1SHQ A;  2VQR A;  1AJD A;  4KAY A;  4CYR A;  1EI6 A;  2W5R A;  1P49 A;  1O99 A;  2IUC A;  1KH5 A;  1KHL A;  1HJK A;  1ANJ A;  3BDG A;  4TN0 A;  2GSO A;  3NKO A;  5EGH A;  4LRE A;  4ZG7 A;  1E1Z P;  1Y6V A;  3UO0 A;  2IFY A;  1HDH A;  3BDH A;  4YR1 A;  5LRN A;  1ALJ A;  5DLW A;  3UN3 A; 
#chains in the Genus database with same CATH topology
 5L0E A;  1SHN A;  1KH9 A;  1KH7 A;  1Y7A A;  1EW9 A;  2W8S A;  1KHK A;  5DLV A;  4UPH A;  4ZGA A;  5DLT A;  5K4P A;  2RH6 A;  1AJA A;  1ELY A;  4KM4 A;  4UPK A;  2QZU A;  3MK1 A;  2W5W A;  5INH A;  3E2D A;  3NKQ A;  3A52 A;  5LRM A;  1N2L A;  1ZED A;  3M8Z A;  2XR9 A;  3MK2 A;  3NKM A;  2D1G A;  3IDD A;  2XRG A;  3M8W A;  4MHX A;  5GOV A;  5LQQ A;  3DPC A;  4GTZ A;  2GLQ A;  3SZZ A;  4LRA A;  1E2S P;  1ZEB A;  5L0B A;  1EW2 A;  1FSU A;  3OT9 A;  5IJS A;  2ANH A;  4GTW A;  3TWZ A;  5GRR A;  3UNY A;  3SZY A;  3BDG B;  3DYC A;  1KHJ A;  3Q3Q A;  4KJD A;  1K7H A;  4UPL A;  1ELZ A;  4LR9 A;  5L0K A;  1KHN A;  4ZG9 A;  1EQJ A;  5LIA A;  1E33 P;  2W5X A;  3B5Q A;  3WAV A;  2W5Q A;  5AJ9 A;  1ALH A;  4FDI A;  4ZG6 A;  2GA3 A;  4CXK A;  4GTX A;  1URA A;  1URB A;  3IGZ B;  3M8Y A;  3MK0 A;  4GTY A;  1B8J A;  4NWX A;  4LRC A;  4CXS A;  4MIV A;  1AUK A;  2W8D A;  1AJC A;  1KH4 A;  4LRF A;  1ANI A;  4UOR A;  4FDJ A;  4LR8 A;  3T02 A;  1AJB A;  3TX0 A;  1ZEF A;  1ALK A;  3WAX A;  1N2K A;  2GSN A;  2ZKT A;  3UN2 A;  3NKN A;  5EGE A;  4LRB A;  1ED9 A;  4QAX A;  4UOP A;  3NKP A;  2IUC B;  3BDF A;  2W5V A;  5HRT A;  4LRD A;  4UOO A;  1EJJ A;  4KAV A;  3M7V A;  3WBH A;  3NKR A;  4MY4 A;  3UN5 A;  2G9Y A;  3KD8 A;  3T00 A;  2W5S A;  1ELX A;  5TJ3 A;  1ED8 A;  2GSU A;  4LR7 A;  5KXA A;  3IGY B;  2X98 A;  1HQA A;  4LQY A;  5IJQ A;  3WAY A;  1EW8 A;  4CXU A;  3CMR A;  3TG0 A;  4KJG A;  3T01 A;  1ALI A;  4LR2 A;  4N7T A;  4CYS A;  4NWJ A;  1E3C P;  3LXQ A;  3WAW A;  2W5T A;  3ED4 A;  4UPI A;  3NVL A;  5C66 A;  1O98 A;  4B56 A;  1SHQ A;  2VQR A;  1AJD A;  4KAY A;  4CYR A;  1EI6 A;  2W5R A;  1P49 A;  1O99 A;  2IUC A;  1KH5 A;  1KHL A;  1HJK A;  1ANJ A;  3BDG A;  4TN0 A;  2GSO A;  3NKO A;  5EGH A;  4LRE A;  4ZG7 A;  1E1Z P;  1Y6V A;  3UO0 A;  2IFY A;  1HDH A;  3BDH A;  4YR1 A;  5LRN A;  1ALJ A;  5DLW A;  3UN3 A; 
#chains in the Genus database with same CATH homology
 5L0E A;  1SHN A;  1KH9 A;  1KH7 A;  1Y7A A;  1EW9 A;  2W8S A;  1KHK A;  5DLV A;  4UPH A;  4ZGA A;  5DLT A;  5K4P A;  2RH6 A;  1AJA A;  1ELY A;  4KM4 A;  4UPK A;  2QZU A;  3MK1 A;  2W5W A;  5INH A;  3E2D A;  3NKQ A;  3A52 A;  5LRM A;  1N2L A;  1ZED A;  3M8Z A;  2XR9 A;  3MK2 A;  3NKM A;  2D1G A;  3IDD A;  2XRG A;  3M8W A;  4MHX A;  5GOV A;  5LQQ A;  3DPC A;  4GTZ A;  2GLQ A;  3SZZ A;  4LRA A;  1E2S P;  1ZEB A;  5L0B A;  1EW2 A;  1FSU A;  3OT9 A;  5IJS A;  2ANH A;  4GTW A;  3TWZ A;  5GRR A;  3UNY A;  3SZY A;  3BDG B;  3DYC A;  1KHJ A;  3Q3Q A;  4KJD A;  1K7H A;  4UPL A;  1ELZ A;  4LR9 A;  5L0K A;  1KHN A;  4ZG9 A;  1EQJ A;  5LIA A;  1E33 P;  2W5X A;  3B5Q A;  3WAV A;  2W5Q A;  5AJ9 A;  1ALH A;  4FDI A;  4ZG6 A;  2GA3 A;  4CXK A;  4GTX A;  1URA A;  1URB A;  3IGZ B;  3M8Y A;  3MK0 A;  4GTY A;  1B8J A;  4NWX A;  4LRC A;  4CXS A;  4MIV A;  1AUK A;  2W8D A;  1AJC A;  1KH4 A;  4LRF A;  1ANI A;  4UOR A;  4FDJ A;  4LR8 A;  3T02 A;  1AJB A;  3TX0 A;  1ZEF A;  1ALK A;  3WAX A;  1N2K A;  2GSN A;  2ZKT A;  3UN2 A;  3NKN A;  5EGE A;  4LRB A;  1ED9 A;  4QAX A;  4UOP A;  3NKP A;  2IUC B;  3BDF A;  2W5V A;  5HRT A;  4LRD A;  4UOO A;  1EJJ A;  4KAV A;  3M7V A;  3WBH A;  3NKR A;  4MY4 A;  3UN5 A;  2G9Y A;  3KD8 A;  3T00 A;  2W5S A;  1ELX A;  5TJ3 A;  1ED8 A;  2GSU A;  4LR7 A;  5KXA A;  3IGY B;  2X98 A;  1HQA A;  4LQY A;  5IJQ A;  3WAY A;  1EW8 A;  4CXU A;  3CMR A;  3TG0 A;  4KJG A;  3T01 A;  1ALI A;  4LR2 A;  4N7T A;  4CYS A;  4NWJ A;  1E3C P;  3LXQ A;  3WAW A;  2W5T A;  3ED4 A;  4UPI A;  3NVL A;  5C66 A;  1O98 A;  4B56 A;  1SHQ A;  2VQR A;  1AJD A;  4KAY A;  4CYR A;  1EI6 A;  2W5R A;  1P49 A;  1O99 A;  2IUC A;  1KH5 A;  1KHL A;  1HJK A;  1ANJ A;  3BDG A;  4TN0 A;  2GSO A;  3NKO A;  5EGH A;  4LRE A;  4ZG7 A;  1E1Z P;  1Y6V A;  3UO0 A;  2IFY A;  1HDH A;  3BDH A;  4YR1 A;  5LRN A;  1ALJ A;  5DLW A;  3UN3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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