1ELXA

E. coli alkaline phosphatase mutant (s102a)
Total Genus 153
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
153
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Kinetic and X-ray structural studies of three mutant E. coli alkaline phosphatases: insights into the catalytic mechanism without the nucleophile Ser102.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 153
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1998-02-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1elxA00
2W5WA 1KHKA 3BDHA 4LQYA 5EGEA 3NKOA 4TN0A 1ELYA 1AJBA 5GOVA 4ZG9A 1KH9A 1ZEFA 4CXSA 4CXKA 3IGYB 3NKPA 1ALKA 5EGHA 5IJSA 1KH5A 1URBA 3M8YA 5LIAA 3NVLA 2ANHA 3LXQA 5INHA 1E1ZP 4GTYA 3TX0A 4NWJA 2W5QA 4FDJA 3ED4A 1ED8A 5L0EA 3SZYA 4QAXA 3IGZB 4LREA 3MK1A 4LRBA 5LRMA 5IJQA 3E2DA 4ZG6A 1EW9A 3TWZA 3A52A 1E3CP 3Q3QA 4LR9A 1E33P 3M7VA 4LRCA 1ANIA 3T00A 3B5QA 3WAWA 2GLQA 3UO0A 1ALHA 4GTXA 1EQJA 3WAXA 4UORA 1KHNA 4YR1A 1E2SP 2GSNA 3CMRA 3OT9A 3NKQA 1ALIA 1SHQA 2W8SA 5C66A 1Y6VA 1EW8A 1HDHA 5LRNA 3T02A 2GSOA 5DLTA 1URAA 3UN2A 4CYRA 4MIVA 5L0BA 4UPLA 3MK2A 3UNYA 1KH7A 4LRDA 5TJ3A 1P49A 2W5SA 4KJGA 1KHJA 1FSUA 2W8DA 1N2LA 5K4PA 4CYSA 2IFYA 4LR8A 2QZUA 4UOOA 1AJCA 5AJ9A 3T01A 1ZEDA 3BDGB 1EW2A 1O99A 5LQQA 4LR2A 3BDGA 4KJDA 4N7TA 1HJKA 2IUCB 2W5VA 2IUCA 4KM4A 3TG0A 4B56A 2G9YA 1AJDA 2W5RA 4ZGAA 3M8WA 5L0KA 3NKNA 4FDIA 2GSUA 4GTWA 4ZG7A 3DPCA 2ZKTA 1KHLA 1Y7AA 1ANJA 4KAVA 3SZZA 3DYCA 4UOPA 4CXUA 2GA3A 3NKMA 1EI6A 1EJJA 3WAYA 5DLVA 5GRRA 1ELZA 2D1GA 1SHNA 1AJAA 3KD8A 3MK0A 5KXAA 1N2KA 4LRAA 3WAVA 3UN5A 4KAYA 4UPKA 5HRTA 4UPHA 3WBHA 1B8JA 4MY4A 1ED9A 1AUKA 2W5XA 1K7HA 1ZEBA 2X98A 3BDFA 4NWXA 3IDDA 5DLWA 3M8ZA 4GTZA 3NKRA 1KH4A 4LRFA 2XRGA 2VQRA 4MHXA 2RH6A 1HQAA 3UN3A 2W5TA 1ALJA 1O98A 4UPIA 4LR7A 2XR9A 1ELXA
chains in the Genus database with same CATH superfamily
2W5WA 1KHKA 3BDHA 4LQYA 5EGEA 3NKOA 4TN0A 1ELYA 1AJBA 5GOVA 4ZG9A 1KH9A 1ZEFA 4CXSA 4CXKA 3IGYB 3NKPA 1ALKA 5EGHA 5IJSA 1KH5A 1URBA 3M8YA 5LIAA 3NVLA 2ANHA 3LXQA 5INHA 1E1ZP 4GTYA 3TX0A 4NWJA 2W5QA 4FDJA 3ED4A 1ED8A 5L0EA 3SZYA 4QAXA 3IGZB 4LREA 3MK1A 4LRBA 5LRMA 5IJQA 3E2DA 4ZG6A 1EW9A 3TWZA 3A52A 1E3CP 3Q3QA 4LR9A 1E33P 3M7VA 4LRCA 1ANIA 3T00A 3B5QA 3WAWA 2GLQA 3UO0A 1ALHA 4GTXA 1EQJA 3WAXA 4UORA 1KHNA 4YR1A 1E2SP 2GSNA 3CMRA 3OT9A 3NKQA 1ALIA 1SHQA 2W8SA 5C66A 1Y6VA 1EW8A 1HDHA 5LRNA 3T02A 2GSOA 5DLTA 1URAA 3UN2A 4CYRA 4MIVA 5L0BA 4UPLA 3MK2A 3UNYA 1KH7A 4LRDA 5TJ3A 1P49A 2W5SA 4KJGA 1KHJA 1FSUA 2W8DA 1N2LA 5K4PA 4CYSA 2IFYA 4LR8A 2QZUA 4UOOA 1AJCA 5AJ9A 3T01A 1ZEDA 3BDGB 1EW2A 1O99A 5LQQA 4LR2A 3BDGA 4KJDA 4N7TA 1HJKA 2IUCB 2W5VA 2IUCA 4KM4A 3TG0A 4B56A 2G9YA 1AJDA 2W5RA 4ZGAA 3M8WA 5L0KA 3NKNA 4FDIA 2GSUA 4GTWA 4ZG7A 3DPCA 2ZKTA 1KHLA 1Y7AA 1ANJA 4KAVA 3SZZA 3DYCA 4UOPA 4CXUA 2GA3A 3NKMA 1EI6A 1EJJA 3WAYA 5DLVA 5GRRA 1ELZA 2D1GA 1SHNA 1AJAA 3KD8A 3MK0A 5KXAA 1N2KA 4LRAA 3WAVA 3UN5A 4KAYA 4UPKA 5HRTA 4UPHA 3WBHA 1B8JA 4MY4A 1ED9A 1AUKA 2W5XA 1K7HA 1ZEBA 2X98A 3BDFA 4NWXA 3IDDA 5DLWA 3M8ZA 4GTZA 3NKRA 1KH4A 4LRFA 2XRGA 2VQRA 4MHXA 2RH6A 1HQAA 3UN3A 2W5TA 1ALJA 1O98A 4UPIA 4LR7A 2XR9A 1ELXA
chains in the Genus database with same CATH topology
2W5WA 1KHKA 3BDHA 4LQYA 5EGEA 3NKOA 4TN0A 1ELYA 1AJBA 5GOVA 4ZG9A 1KH9A 1ZEFA 4CXSA 4CXKA 3IGYB 3NKPA 1ALKA 5EGHA 5IJSA 1KH5A 1URBA 3M8YA 5LIAA 3NVLA 2ANHA 3LXQA 5INHA 1E1ZP 4GTYA 3TX0A 4NWJA 2W5QA 4FDJA 3ED4A 1ED8A 5L0EA 3SZYA 4QAXA 3IGZB 4LREA 3MK1A 4LRBA 5LRMA 5IJQA 3E2DA 4ZG6A 1EW9A 3TWZA 3A52A 1E3CP 3Q3QA 4LR9A 1E33P 3M7VA 4LRCA 1ANIA 3T00A 3B5QA 3WAWA 2GLQA 3UO0A 1ALHA 4GTXA 1EQJA 3WAXA 4UORA 1KHNA 4YR1A 1E2SP 2GSNA 3CMRA 3OT9A 3NKQA 1ALIA 1SHQA 2W8SA 5C66A 1Y6VA 1EW8A 1HDHA 5LRNA 3T02A 2GSOA 5DLTA 1URAA 3UN2A 4CYRA 4MIVA 5L0BA 4UPLA 3MK2A 3UNYA 1KH7A 4LRDA 5TJ3A 1P49A 2W5SA 4KJGA 1KHJA 1FSUA 2W8DA 1N2LA 5K4PA 4CYSA 2IFYA 4LR8A 2QZUA 4UOOA 1AJCA 5AJ9A 3T01A 1ZEDA 3BDGB 1EW2A 1O99A 5LQQA 4LR2A 3BDGA 4KJDA 4N7TA 1HJKA 2IUCB 2W5VA 2IUCA 4KM4A 3TG0A 4B56A 2G9YA 1AJDA 2W5RA 4ZGAA 3M8WA 5L0KA 3NKNA 4FDIA 2GSUA 4GTWA 4ZG7A 3DPCA 2ZKTA 1KHLA 1Y7AA 1ANJA 4KAVA 3SZZA 3DYCA 4UOPA 4CXUA 2GA3A 3NKMA 1EI6A 1EJJA 3WAYA 5DLVA 5GRRA 1ELZA 2D1GA 1SHNA 1AJAA 3KD8A 3MK0A 5KXAA 1N2KA 4LRAA 3WAVA 3UN5A 4KAYA 4UPKA 5HRTA 4UPHA 3WBHA 1B8JA 4MY4A 1ED9A 1AUKA 2W5XA 1K7HA 1ZEBA 2X98A 3BDFA 4NWXA 3IDDA 5DLWA 3M8ZA 4GTZA 3NKRA 1KH4A 4LRFA 2XRGA 2VQRA 4MHXA 2RH6A 1HQAA 3UN3A 2W5TA 1ALJA 1O98A 4UPIA 4LR7A 2XR9A 1ELXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2W5W A;  1KHK A;  3BDH A;  4LQY A;  5EGE A;  3NKO A;  4TN0 A;  1ELY A;  1AJB A;  5GOV A;  4ZG9 A;  1KH9 A;  1ZEF A;  4CXS A;  4CXK A;  3IGY B;  3NKP A;  1ALK A;  5EGH A;  5IJS A;  1KH5 A;  1URB A;  3M8Y A;  5LIA A;  3NVL A;  2ANH A;  3LXQ A;  5INH A;  1E1Z P;  4GTY A;  3TX0 A;  4NWJ A;  2W5Q A;  4FDJ A;  3ED4 A;  1ED8 A;  5L0E A;  3SZY A;  4QAX A;  3IGZ B;  4LRE A;  3MK1 A;  4LRB A;  5LRM A;  5IJQ A;  3E2D A;  4ZG6 A;  1EW9 A;  3TWZ A;  3A52 A;  1E3C P;  3Q3Q A;  4LR9 A;  1E33 P;  3M7V A;  4LRC A;  1ANI A;  3T00 A;  3B5Q A;  3WAW A;  2GLQ A;  3UO0 A;  1ALH A;  4GTX A;  1EQJ A;  3WAX A;  4UOR A;  1KHN A;  4YR1 A;  1E2S P;  2GSN A;  3CMR A;  3OT9 A;  3NKQ A;  1ALI A;  1SHQ A;  2W8S A;  5C66 A;  1Y6V A;  1EW8 A;  1HDH A;  5LRN A;  3T02 A;  2GSO A;  5DLT A;  1URA A;  3UN2 A;  4CYR A;  4MIV A;  5L0B A;  4UPL A;  3MK2 A;  3UNY A;  1KH7 A;  4LRD A;  5TJ3 A;  1P49 A;  2W5S A;  4KJG A;  1KHJ A;  1FSU A;  2W8D A;  1N2L A;  5K4P A;  4CYS A;  2IFY A;  4LR8 A;  2QZU A;  4UOO A;  1AJC A;  5AJ9 A;  3T01 A;  1ZED A;  3BDG B;  1EW2 A;  1O99 A;  5LQQ A;  4LR2 A;  3BDG A;  4KJD A;  4N7T A;  1HJK A;  2IUC B;  2W5V A;  2IUC A;  4KM4 A;  3TG0 A;  4B56 A;  2G9Y A;  1AJD A;  2W5R A;  4ZGA A;  3M8W A;  5L0K A;  3NKN A;  4FDI A;  2GSU A;  4GTW A;  4ZG7 A;  3DPC A;  2ZKT A;  1KHL A;  1Y7A A;  1ANJ A;  4KAV A;  3SZZ A;  3DYC A;  4UOP A;  4CXU A;  2GA3 A;  3NKM A;  1EI6 A;  1EJJ A;  3WAY A;  5DLV A;  5GRR A;  1ELZ A;  2D1G A;  1SHN A;  1AJA A;  3KD8 A;  3MK0 A;  5KXA A;  1N2K A;  4LRA A;  3WAV A;  3UN5 A;  4KAY A;  4UPK A;  5HRT A;  4UPH A;  3WBH A;  1B8J A;  4MY4 A;  1ED9 A;  1AUK A;  2W5X A;  1K7H A;  1ZEB A;  2X98 A;  3BDF A;  4NWX A;  3IDD A;  5DLW A;  3M8Z A;  4GTZ A;  3NKR A;  1KH4 A;  4LRF A;  2XRG A;  2VQR A;  4MHX A;  2RH6 A;  1HQA A;  3UN3 A;  2W5T A;  1ALJ A;  1O98 A;  4UPI A;  4LR7 A;  2XR9 A;  1ELX A; 
#chains in the Genus database with same CATH topology
 2W5W A;  1KHK A;  3BDH A;  4LQY A;  5EGE A;  3NKO A;  4TN0 A;  1ELY A;  1AJB A;  5GOV A;  4ZG9 A;  1KH9 A;  1ZEF A;  4CXS A;  4CXK A;  3IGY B;  3NKP A;  1ALK A;  5EGH A;  5IJS A;  1KH5 A;  1URB A;  3M8Y A;  5LIA A;  3NVL A;  2ANH A;  3LXQ A;  5INH A;  1E1Z P;  4GTY A;  3TX0 A;  4NWJ A;  2W5Q A;  4FDJ A;  3ED4 A;  1ED8 A;  5L0E A;  3SZY A;  4QAX A;  3IGZ B;  4LRE A;  3MK1 A;  4LRB A;  5LRM A;  5IJQ A;  3E2D A;  4ZG6 A;  1EW9 A;  3TWZ A;  3A52 A;  1E3C P;  3Q3Q A;  4LR9 A;  1E33 P;  3M7V A;  4LRC A;  1ANI A;  3T00 A;  3B5Q A;  3WAW A;  2GLQ A;  3UO0 A;  1ALH A;  4GTX A;  1EQJ A;  3WAX A;  4UOR A;  1KHN A;  4YR1 A;  1E2S P;  2GSN A;  3CMR A;  3OT9 A;  3NKQ A;  1ALI A;  1SHQ A;  2W8S A;  5C66 A;  1Y6V A;  1EW8 A;  1HDH A;  5LRN A;  3T02 A;  2GSO A;  5DLT A;  1URA A;  3UN2 A;  4CYR A;  4MIV A;  5L0B A;  4UPL A;  3MK2 A;  3UNY A;  1KH7 A;  4LRD A;  5TJ3 A;  1P49 A;  2W5S A;  4KJG A;  1KHJ A;  1FSU A;  2W8D A;  1N2L A;  5K4P A;  4CYS A;  2IFY A;  4LR8 A;  2QZU A;  4UOO A;  1AJC A;  5AJ9 A;  3T01 A;  1ZED A;  3BDG B;  1EW2 A;  1O99 A;  5LQQ A;  4LR2 A;  3BDG A;  4KJD A;  4N7T A;  1HJK A;  2IUC B;  2W5V A;  2IUC A;  4KM4 A;  3TG0 A;  4B56 A;  2G9Y A;  1AJD A;  2W5R A;  4ZGA A;  3M8W A;  5L0K A;  3NKN A;  4FDI A;  2GSU A;  4GTW A;  4ZG7 A;  3DPC A;  2ZKT A;  1KHL A;  1Y7A A;  1ANJ A;  4KAV A;  3SZZ A;  3DYC A;  4UOP A;  4CXU A;  2GA3 A;  3NKM A;  1EI6 A;  1EJJ A;  3WAY A;  5DLV A;  5GRR A;  1ELZ A;  2D1G A;  1SHN A;  1AJA A;  3KD8 A;  3MK0 A;  5KXA A;  1N2K A;  4LRA A;  3WAV A;  3UN5 A;  4KAY A;  4UPK A;  5HRT A;  4UPH A;  3WBH A;  1B8J A;  4MY4 A;  1ED9 A;  1AUK A;  2W5X A;  1K7H A;  1ZEB A;  2X98 A;  3BDF A;  4NWX A;  3IDD A;  5DLW A;  3M8Z A;  4GTZ A;  3NKR A;  1KH4 A;  4LRF A;  2XRG A;  2VQR A;  4MHX A;  2RH6 A;  1HQA A;  3UN3 A;  2W5T A;  1ALJ A;  1O98 A;  4UPI A;  4LR7 A;  2XR9 A;  1ELX A; 
#chains in the Genus database with same CATH homology
 2W5W A;  1KHK A;  3BDH A;  4LQY A;  5EGE A;  3NKO A;  4TN0 A;  1ELY A;  1AJB A;  5GOV A;  4ZG9 A;  1KH9 A;  1ZEF A;  4CXS A;  4CXK A;  3IGY B;  3NKP A;  1ALK A;  5EGH A;  5IJS A;  1KH5 A;  1URB A;  3M8Y A;  5LIA A;  3NVL A;  2ANH A;  3LXQ A;  5INH A;  1E1Z P;  4GTY A;  3TX0 A;  4NWJ A;  2W5Q A;  4FDJ A;  3ED4 A;  1ED8 A;  5L0E A;  3SZY A;  4QAX A;  3IGZ B;  4LRE A;  3MK1 A;  4LRB A;  5LRM A;  5IJQ A;  3E2D A;  4ZG6 A;  1EW9 A;  3TWZ A;  3A52 A;  1E3C P;  3Q3Q A;  4LR9 A;  1E33 P;  3M7V A;  4LRC A;  1ANI A;  3T00 A;  3B5Q A;  3WAW A;  2GLQ A;  3UO0 A;  1ALH A;  4GTX A;  1EQJ A;  3WAX A;  4UOR A;  1KHN A;  4YR1 A;  1E2S P;  2GSN A;  3CMR A;  3OT9 A;  3NKQ A;  1ALI A;  1SHQ A;  2W8S A;  5C66 A;  1Y6V A;  1EW8 A;  1HDH A;  5LRN A;  3T02 A;  2GSO A;  5DLT A;  1URA A;  3UN2 A;  4CYR A;  4MIV A;  5L0B A;  4UPL A;  3MK2 A;  3UNY A;  1KH7 A;  4LRD A;  5TJ3 A;  1P49 A;  2W5S A;  4KJG A;  1KHJ A;  1FSU A;  2W8D A;  1N2L A;  5K4P A;  4CYS A;  2IFY A;  4LR8 A;  2QZU A;  4UOO A;  1AJC A;  5AJ9 A;  3T01 A;  1ZED A;  3BDG B;  1EW2 A;  1O99 A;  5LQQ A;  4LR2 A;  3BDG A;  4KJD A;  4N7T A;  1HJK A;  2IUC B;  2W5V A;  2IUC A;  4KM4 A;  3TG0 A;  4B56 A;  2G9Y A;  1AJD A;  2W5R A;  4ZGA A;  3M8W A;  5L0K A;  3NKN A;  4FDI A;  2GSU A;  4GTW A;  4ZG7 A;  3DPC A;  2ZKT A;  1KHL A;  1Y7A A;  1ANJ A;  4KAV A;  3SZZ A;  3DYC A;  4UOP A;  4CXU A;  2GA3 A;  3NKM A;  1EI6 A;  1EJJ A;  3WAY A;  5DLV A;  5GRR A;  1ELZ A;  2D1G A;  1SHN A;  1AJA A;  3KD8 A;  3MK0 A;  5KXA A;  1N2K A;  4LRA A;  3WAV A;  3UN5 A;  4KAY A;  4UPK A;  5HRT A;  4UPH A;  3WBH A;  1B8J A;  4MY4 A;  1ED9 A;  1AUK A;  2W5X A;  1K7H A;  1ZEB A;  2X98 A;  3BDF A;  4NWX A;  3IDD A;  5DLW A;  3M8Z A;  4GTZ A;  3NKR A;  1KH4 A;  4LRF A;  2XRG A;  2VQR A;  4MHX A;  2RH6 A;  1HQA A;  3UN3 A;  2W5T A;  1ALJ A;  1O98 A;  4UPI A;  4LR7 A;  2XR9 A;  1ELX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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