1EW8A

Alkaline phosphatase (e.c. 3.1.3.1) complex with phosphonoacetic acid
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
molecule keywords ALKALINE PHOSPHATASE
source organism Escherichia coli
molecule tags Hydrolase
total genus 155
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew8A00
1ALIA 4KAVA 1EJJA 3T00A 2ZKTA 5L0EA 3T02A 4N7TA 3NKOA 4KAYA 4GTXA 3UO0A 3KD8A 3BDHA 2W5VA 1E2SP 4GTWA 4KM4A 2W5QA 2IUCB 4LREA 3WAXA 1ED9A 5L0KA 3BDFA 5GOVA 3Q3QA 4LR9A 4MHXA 1ELYA 1ALJA 3NKNA 3DYCA 5IJQA 4CYRA 4CXSA 2GA3A 3B5QA 2X98A 1AJDA 1ELZA 3NKQA 3NKPA 4LRDA 3M7VA 1E1ZP 3DPCA 2G9YA 2XRGA 3BDGB 3NKRA 1P49A 4QAXA 1E3CP 3OT9A 5EGHA 1ZEFA 5DLWA 4ZG6A 5LQQA 1KH7A 4ZGAA 1EW9A 3E2DA 5DLTA 1K7HA 3TG0A 3WAVA 2IUCA 4MY4A 1EW8A 1O98A 1ANJA 5AJ9A 5HRTA 3UNYA 4UOOA 2VQRA 3WAYA 2GSNA 5C66A 4UPKA 3WBHA 3TWZA 5LRNA 5L0BA 1ED8A 1FSUA 1KH9A 2W5TA 4LQYA 3M8YA 4LRFA 1E33P 1SHNA 3BDGA 3UN2A 1AJBA 2W5SA 4KJDA 5DLVA 3CMRA 1Y7AA 4UPIA 3IDDA 4TN0A 4FDJA 5KXAA 5EGEA 1O99A 3A52A 4FDIA 4UPHA 2W8DA 1KHKA 1B8JA 3M8ZA 1KH4A 4LR2A 2RH6A 1KHNA 4CXUA 1N2KA 2ANHA 5K4PA 3M8WA 1ALKA 4GTYA 1HQAA 4MIVA 2W5WA 3MK0A 3SZYA 5LIAA 4UPLA 5INHA 1ANIA 5IJSA 1EQJA 3MK2A 1Y6VA 3UN3A 3UN5A 1AUKA 4LR8A 4LR7A 3LXQA 1ALHA 1HJKA 4ZG9A 4NWXA 4LRBA 3T01A 1KHLA 4CYSA 1EW2A 5LRMA 4B56A 4CXKA 1AJAA 4NWJA 4UORA 3SZZA 2W5XA 4GTZA 2GLQA 3NKMA 1ZEBA 1EI6A 1KH5A 1N2LA 5GRRA 2IFYA 1URAA 2XR9A 3MK1A 1URBA 3IGZB 1ZEDA 1AJCA 4KJGA 1ELXA 2D1GA 3WAWA 3ED4A 4LRCA 4LRAA 4UOPA 2W5RA 2W8SA 2GSUA 1HDHA 2GSOA 3NVLA 2QZUA 3IGYB 5TJ3A 4YR1A 1KHJA 1SHQA 3TX0A 4ZG7A
chains in the Genus database with same CATH superfamily
1ALIA 4KAVA 1EJJA 3T00A 2ZKTA 5L0EA 3T02A 4N7TA 3NKOA 4KAYA 4GTXA 3UO0A 3KD8A 3BDHA 2W5VA 1E2SP 4GTWA 4KM4A 2W5QA 2IUCB 4LREA 3WAXA 1ED9A 5L0KA 3BDFA 5GOVA 3Q3QA 4LR9A 4MHXA 1ELYA 1ALJA 3NKNA 3DYCA 5IJQA 4CYRA 4CXSA 2GA3A 3B5QA 2X98A 1AJDA 1ELZA 3NKQA 3NKPA 4LRDA 3M7VA 1E1ZP 3DPCA 2G9YA 2XRGA 3BDGB 3NKRA 1P49A 4QAXA 1E3CP 3OT9A 5EGHA 1ZEFA 5DLWA 4ZG6A 5LQQA 1KH7A 4ZGAA 1EW9A 3E2DA 5DLTA 1K7HA 3TG0A 3WAVA 2IUCA 4MY4A 1EW8A 1O98A 1ANJA 5AJ9A 5HRTA 3UNYA 4UOOA 2VQRA 3WAYA 2GSNA 5C66A 4UPKA 3WBHA 3TWZA 5LRNA 5L0BA 1ED8A 1FSUA 1KH9A 2W5TA 4LQYA 3M8YA 4LRFA 1E33P 1SHNA 3BDGA 3UN2A 1AJBA 2W5SA 4KJDA 5DLVA 3CMRA 1Y7AA 4UPIA 3IDDA 4TN0A 4FDJA 5KXAA 5EGEA 1O99A 3A52A 4FDIA 4UPHA 2W8DA 1KHKA 1B8JA 3M8ZA 1KH4A 4LR2A 2RH6A 1KHNA 4CXUA 1N2KA 2ANHA 5K4PA 3M8WA 1ALKA 4GTYA 1HQAA 4MIVA 2W5WA 3MK0A 3SZYA 5LIAA 4UPLA 5INHA 1ANIA 5IJSA 1EQJA 3MK2A 1Y6VA 3UN3A 3UN5A 1AUKA 4LR8A 4LR7A 3LXQA 1ALHA 1HJKA 4ZG9A 4NWXA 4LRBA 3T01A 1KHLA 4CYSA 1EW2A 5LRMA 4B56A 4CXKA 1AJAA 4NWJA 4UORA 3SZZA 2W5XA 4GTZA 2GLQA 3NKMA 1ZEBA 1EI6A 1KH5A 1N2LA 5GRRA 2IFYA 1URAA 2XR9A 3MK1A 1URBA 3IGZB 1ZEDA 1AJCA 4KJGA 1ELXA 2D1GA 3WAWA 3ED4A 4LRCA 4LRAA 4UOPA 2W5RA 2W8SA 2GSUA 1HDHA 2GSOA 3NVLA 2QZUA 3IGYB 5TJ3A 4YR1A 1KHJA 1SHQA 3TX0A 4ZG7A
chains in the Genus database with same CATH topology
1ALIA 4KAVA 1EJJA 3T00A 2ZKTA 5L0EA 3T02A 4N7TA 3NKOA 4KAYA 4GTXA 3UO0A 3KD8A 3BDHA 2W5VA 1E2SP 4GTWA 4KM4A 2W5QA 2IUCB 4LREA 3WAXA 1ED9A 5L0KA 3BDFA 5GOVA 3Q3QA 4LR9A 4MHXA 1ELYA 1ALJA 3NKNA 3DYCA 5IJQA 4CYRA 4CXSA 2GA3A 3B5QA 2X98A 1AJDA 1ELZA 3NKQA 3NKPA 4LRDA 3M7VA 1E1ZP 3DPCA 2G9YA 2XRGA 3BDGB 3NKRA 1P49A 4QAXA 1E3CP 3OT9A 5EGHA 1ZEFA 5DLWA 4ZG6A 5LQQA 1KH7A 4ZGAA 1EW9A 3E2DA 5DLTA 1K7HA 3TG0A 3WAVA 2IUCA 4MY4A 1EW8A 1O98A 1ANJA 5AJ9A 5HRTA 3UNYA 4UOOA 2VQRA 3WAYA 2GSNA 5C66A 4UPKA 3WBHA 3TWZA 5LRNA 5L0BA 1ED8A 1FSUA 1KH9A 2W5TA 4LQYA 3M8YA 4LRFA 1E33P 1SHNA 3BDGA 3UN2A 1AJBA 2W5SA 4KJDA 5DLVA 3CMRA 1Y7AA 4UPIA 3IDDA 4TN0A 4FDJA 5KXAA 5EGEA 1O99A 3A52A 4FDIA 4UPHA 2W8DA 1KHKA 1B8JA 3M8ZA 1KH4A 4LR2A 2RH6A 1KHNA 4CXUA 1N2KA 2ANHA 5K4PA 3M8WA 1ALKA 4GTYA 1HQAA 4MIVA 2W5WA 3MK0A 3SZYA 5LIAA 4UPLA 5INHA 1ANIA 5IJSA 1EQJA 3MK2A 1Y6VA 3UN3A 3UN5A 1AUKA 4LR8A 4LR7A 3LXQA 1ALHA 1HJKA 4ZG9A 4NWXA 4LRBA 3T01A 1KHLA 4CYSA 1EW2A 5LRMA 4B56A 4CXKA 1AJAA 4NWJA 4UORA 3SZZA 2W5XA 4GTZA 2GLQA 3NKMA 1ZEBA 1EI6A 1KH5A 1N2LA 5GRRA 2IFYA 1URAA 2XR9A 3MK1A 1URBA 3IGZB 1ZEDA 1AJCA 4KJGA 1ELXA 2D1GA 3WAWA 3ED4A 4LRCA 4LRAA 4UOPA 2W5RA 2W8SA 2GSUA 1HDHA 2GSOA 3NVLA 2QZUA 3IGYB 5TJ3A 4YR1A 1KHJA 1SHQA 3TX0A 4ZG7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ALI A;  4KAV A;  1EJJ A;  3T00 A;  2ZKT A;  5L0E A;  3T02 A;  4N7T A;  3NKO A;  4KAY A;  4GTX A;  3UO0 A;  3KD8 A;  3BDH A;  2W5V A;  1E2S P;  4GTW A;  4KM4 A;  2W5Q A;  2IUC B;  4LRE A;  3WAX A;  1ED9 A;  5L0K A;  3BDF A;  5GOV A;  3Q3Q A;  4LR9 A;  4MHX A;  1ELY A;  1ALJ A;  3NKN A;  3DYC A;  5IJQ A;  4CYR A;  4CXS A;  2GA3 A;  3B5Q A;  2X98 A;  1AJD A;  1ELZ A;  3NKQ A;  3NKP A;  4LRD A;  3M7V A;  1E1Z P;  3DPC A;  2G9Y A;  2XRG A;  3BDG B;  3NKR A;  1P49 A;  4QAX A;  1E3C P;  3OT9 A;  5EGH A;  1ZEF A;  5DLW A;  4ZG6 A;  5LQQ A;  1KH7 A;  4ZGA A;  1EW9 A;  3E2D A;  5DLT A;  1K7H A;  3TG0 A;  3WAV A;  2IUC A;  4MY4 A;  1EW8 A;  1O98 A;  1ANJ A;  5AJ9 A;  5HRT A;  3UNY A;  4UOO A;  2VQR A;  3WAY A;  2GSN A;  5C66 A;  4UPK A;  3WBH A;  3TWZ A;  5LRN A;  5L0B A;  1ED8 A;  1FSU A;  1KH9 A;  2W5T A;  4LQY A;  3M8Y A;  4LRF A;  1E33 P;  1SHN A;  3BDG A;  3UN2 A;  1AJB A;  2W5S A;  4KJD A;  5DLV A;  3CMR A;  1Y7A A;  4UPI A;  3IDD A;  4TN0 A;  4FDJ A;  5KXA A;  5EGE A;  1O99 A;  3A52 A;  4FDI A;  4UPH A;  2W8D A;  1KHK A;  1B8J A;  3M8Z A;  1KH4 A;  4LR2 A;  2RH6 A;  1KHN A;  4CXU A;  1N2K A;  2ANH A;  5K4P A;  3M8W A;  1ALK A;  4GTY A;  1HQA A;  4MIV A;  2W5W A;  3MK0 A;  3SZY A;  5LIA A;  4UPL A;  5INH A;  1ANI A;  5IJS A;  1EQJ A;  3MK2 A;  1Y6V A;  3UN3 A;  3UN5 A;  1AUK A;  4LR8 A;  4LR7 A;  3LXQ A;  1ALH A;  1HJK A;  4ZG9 A;  4NWX A;  4LRB A;  3T01 A;  1KHL A;  4CYS A;  1EW2 A;  5LRM A;  4B56 A;  4CXK A;  1AJA A;  4NWJ A;  4UOR A;  3SZZ A;  2W5X A;  4GTZ A;  2GLQ A;  3NKM A;  1ZEB A;  1EI6 A;  1KH5 A;  1N2L A;  5GRR A;  2IFY A;  1URA A;  2XR9 A;  3MK1 A;  1URB A;  3IGZ B;  1ZED A;  1AJC A;  4KJG A;  1ELX A;  2D1G A;  3WAW A;  3ED4 A;  4LRC A;  4LRA A;  4UOP A;  2W5R A;  2W8S A;  2GSU A;  1HDH A;  2GSO A;  3NVL A;  2QZU A;  3IGY B;  5TJ3 A;  4YR1 A;  1KHJ A;  1SHQ A;  3TX0 A;  4ZG7 A; 
#chains in the Genus database with same CATH topology
 1ALI A;  4KAV A;  1EJJ A;  3T00 A;  2ZKT A;  5L0E A;  3T02 A;  4N7T A;  3NKO A;  4KAY A;  4GTX A;  3UO0 A;  3KD8 A;  3BDH A;  2W5V A;  1E2S P;  4GTW A;  4KM4 A;  2W5Q A;  2IUC B;  4LRE A;  3WAX A;  1ED9 A;  5L0K A;  3BDF A;  5GOV A;  3Q3Q A;  4LR9 A;  4MHX A;  1ELY A;  1ALJ A;  3NKN A;  3DYC A;  5IJQ A;  4CYR A;  4CXS A;  2GA3 A;  3B5Q A;  2X98 A;  1AJD A;  1ELZ A;  3NKQ A;  3NKP A;  4LRD A;  3M7V A;  1E1Z P;  3DPC A;  2G9Y A;  2XRG A;  3BDG B;  3NKR A;  1P49 A;  4QAX A;  1E3C P;  3OT9 A;  5EGH A;  1ZEF A;  5DLW A;  4ZG6 A;  5LQQ A;  1KH7 A;  4ZGA A;  1EW9 A;  3E2D A;  5DLT A;  1K7H A;  3TG0 A;  3WAV A;  2IUC A;  4MY4 A;  1EW8 A;  1O98 A;  1ANJ A;  5AJ9 A;  5HRT A;  3UNY A;  4UOO A;  2VQR A;  3WAY A;  2GSN A;  5C66 A;  4UPK A;  3WBH A;  3TWZ A;  5LRN A;  5L0B A;  1ED8 A;  1FSU A;  1KH9 A;  2W5T A;  4LQY A;  3M8Y A;  4LRF A;  1E33 P;  1SHN A;  3BDG A;  3UN2 A;  1AJB A;  2W5S A;  4KJD A;  5DLV A;  3CMR A;  1Y7A A;  4UPI A;  3IDD A;  4TN0 A;  4FDJ A;  5KXA A;  5EGE A;  1O99 A;  3A52 A;  4FDI A;  4UPH A;  2W8D A;  1KHK A;  1B8J A;  3M8Z A;  1KH4 A;  4LR2 A;  2RH6 A;  1KHN A;  4CXU A;  1N2K A;  2ANH A;  5K4P A;  3M8W A;  1ALK A;  4GTY A;  1HQA A;  4MIV A;  2W5W A;  3MK0 A;  3SZY A;  5LIA A;  4UPL A;  5INH A;  1ANI A;  5IJS A;  1EQJ A;  3MK2 A;  1Y6V A;  3UN3 A;  3UN5 A;  1AUK A;  4LR8 A;  4LR7 A;  3LXQ A;  1ALH A;  1HJK A;  4ZG9 A;  4NWX A;  4LRB A;  3T01 A;  1KHL A;  4CYS A;  1EW2 A;  5LRM A;  4B56 A;  4CXK A;  1AJA A;  4NWJ A;  4UOR A;  3SZZ A;  2W5X A;  4GTZ A;  2GLQ A;  3NKM A;  1ZEB A;  1EI6 A;  1KH5 A;  1N2L A;  5GRR A;  2IFY A;  1URA A;  2XR9 A;  3MK1 A;  1URB A;  3IGZ B;  1ZED A;  1AJC A;  4KJG A;  1ELX A;  2D1G A;  3WAW A;  3ED4 A;  4LRC A;  4LRA A;  4UOP A;  2W5R A;  2W8S A;  2GSU A;  1HDH A;  2GSO A;  3NVL A;  2QZU A;  3IGY B;  5TJ3 A;  4YR1 A;  1KHJ A;  1SHQ A;  3TX0 A;  4ZG7 A; 
#chains in the Genus database with same CATH homology
 1ALI A;  4KAV A;  1EJJ A;  3T00 A;  2ZKT A;  5L0E A;  3T02 A;  4N7T A;  3NKO A;  4KAY A;  4GTX A;  3UO0 A;  3KD8 A;  3BDH A;  2W5V A;  1E2S P;  4GTW A;  4KM4 A;  2W5Q A;  2IUC B;  4LRE A;  3WAX A;  1ED9 A;  5L0K A;  3BDF A;  5GOV A;  3Q3Q A;  4LR9 A;  4MHX A;  1ELY A;  1ALJ A;  3NKN A;  3DYC A;  5IJQ A;  4CYR A;  4CXS A;  2GA3 A;  3B5Q A;  2X98 A;  1AJD A;  1ELZ A;  3NKQ A;  3NKP A;  4LRD A;  3M7V A;  1E1Z P;  3DPC A;  2G9Y A;  2XRG A;  3BDG B;  3NKR A;  1P49 A;  4QAX A;  1E3C P;  3OT9 A;  5EGH A;  1ZEF A;  5DLW A;  4ZG6 A;  5LQQ A;  1KH7 A;  4ZGA A;  1EW9 A;  3E2D A;  5DLT A;  1K7H A;  3TG0 A;  3WAV A;  2IUC A;  4MY4 A;  1EW8 A;  1O98 A;  1ANJ A;  5AJ9 A;  5HRT A;  3UNY A;  4UOO A;  2VQR A;  3WAY A;  2GSN A;  5C66 A;  4UPK A;  3WBH A;  3TWZ A;  5LRN A;  5L0B A;  1ED8 A;  1FSU A;  1KH9 A;  2W5T A;  4LQY A;  3M8Y A;  4LRF A;  1E33 P;  1SHN A;  3BDG A;  3UN2 A;  1AJB A;  2W5S A;  4KJD A;  5DLV A;  3CMR A;  1Y7A A;  4UPI A;  3IDD A;  4TN0 A;  4FDJ A;  5KXA A;  5EGE A;  1O99 A;  3A52 A;  4FDI A;  4UPH A;  2W8D A;  1KHK A;  1B8J A;  3M8Z A;  1KH4 A;  4LR2 A;  2RH6 A;  1KHN A;  4CXU A;  1N2K A;  2ANH A;  5K4P A;  3M8W A;  1ALK A;  4GTY A;  1HQA A;  4MIV A;  2W5W A;  3MK0 A;  3SZY A;  5LIA A;  4UPL A;  5INH A;  1ANI A;  5IJS A;  1EQJ A;  3MK2 A;  1Y6V A;  3UN3 A;  3UN5 A;  1AUK A;  4LR8 A;  4LR7 A;  3LXQ A;  1ALH A;  1HJK A;  4ZG9 A;  4NWX A;  4LRB A;  3T01 A;  1KHL A;  4CYS A;  1EW2 A;  5LRM A;  4B56 A;  4CXK A;  1AJA A;  4NWJ A;  4UOR A;  3SZZ A;  2W5X A;  4GTZ A;  2GLQ A;  3NKM A;  1ZEB A;  1EI6 A;  1KH5 A;  1N2L A;  5GRR A;  2IFY A;  1URA A;  2XR9 A;  3MK1 A;  1URB A;  3IGZ B;  1ZED A;  1AJC A;  4KJG A;  1ELX A;  2D1G A;  3WAW A;  3ED4 A;  4LRC A;  4LRA A;  4UOP A;  2W5R A;  2W8S A;  2GSU A;  1HDH A;  2GSO A;  3NVL A;  2QZU A;  3IGY B;  5TJ3 A;  4YR1 A;  1KHJ A;  1SHQ A;  3TX0 A;  4ZG7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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