1EW8A

Alkaline phosphatase (e.c. 3.1.3.1) complex with phosphonoacetic acid
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 155
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew8A00
1ZEBA 4GTYA 4UORA 3WAWA 2RH6A 3MK2A 3DPCA 4LR2A 1EW2A 2W8DA 1ZEFA 1AJBA 4LREA 1URBA 1N2LA 4FDIA 1E1ZP 1ALIA 4KM4A 3MK1A 3UN2A 4CYSA 5LIAA 1ED9A 4GTXA 2G9YA 3NVLA 5L0EA 1KHLA 4ZG7A 3E2DA 3OT9A 3T02A 5LQQA 4CXUA 3ED4A 1EW8A 3BDFA 5DLVA 3IGZB 3NKOA 2GSOA 1ELZA 2IUCB 1P49A 1Y6VA 3M7VA 1ELXA 3BDHA 3BDGB 5K4PA 5KXAA 2W5SA 3WBHA 5L0KA 3WAVA 1KHJA 3IDDA 4CXSA 2ANHA 3SZZA 3T00A 2W5QA 3NKNA 1KHKA 4KAYA 3NKPA 1EW9A 4N7TA 5IJSA 5C66A 5EGHA 4KJGA 4GTZA 2IFYA 1URAA 3Q3QA 1AJDA 1E3CP 3M8YA 4FDJA 1AUKA 5HRTA 1B8JA 4QAXA 3TG0A 5EGEA 3T01A 4KAVA 4UPKA 4LRFA 4MHXA 3WAXA 4ZG6A 5GRRA 4YR1A 1KH9A 2W8SA 4NWXA 2W5VA 1O99A 3BDGA 3NKMA 3UO0A 1KH4A 3M8ZA 3NKRA 1KH5A 2GA3A 2GSUA 4UOPA 4LR8A 5DLWA 4MY4A 1AJAA 1ALKA 3WAYA 3M8WA 1K7HA 4LR7A 4LRCA 2GSNA 4LR9A 3SZYA 2W5RA 4GTWA 1KHNA 3LXQA 3CMRA 5DLTA 1HQAA 4LQYA 5TJ3A 1HJKA 2W5WA 3UN5A 4CXKA 3A52A 3UN3A 5GOVA 1ELYA 1EJJA 2IUCA 4UPHA 3MK0A 2ZKTA 1HDHA 1SHNA 3KD8A 4UPLA 1SHQA 1E33P 3DYCA 4UOOA 1ED8A 4B56A 4LRBA 1E2SP 5L0BA 1AJCA 2VQRA 2GLQA 5IJQA 2D1GA 4KJDA 4NWJA 3TWZA 3B5QA 1ANJA 1O98A 1ANIA 1FSUA 4CYRA 5LRMA 4LRAA 1ALHA 3IGYB 3TX0A 2W5TA 1Y7AA 2QZUA 2X98A 1EQJA 2W5XA 2XRGA 1KH7A 1EI6A 4ZG9A 2XR9A 5INHA 4ZGAA 3NKQA 5LRNA 3UNYA 4UPIA 5AJ9A 1ALJA 4LRDA 4TN0A 1ZEDA 4MIVA 1N2KA
chains in the Genus database with same CATH superfamily
1ZEBA 4GTYA 4UORA 3WAWA 2RH6A 3MK2A 3DPCA 4LR2A 1EW2A 2W8DA 1ZEFA 1AJBA 4LREA 1URBA 1N2LA 4FDIA 1E1ZP 1ALIA 4KM4A 3MK1A 3UN2A 4CYSA 5LIAA 1ED9A 4GTXA 2G9YA 3NVLA 5L0EA 1KHLA 4ZG7A 3E2DA 3OT9A 3T02A 5LQQA 4CXUA 3ED4A 1EW8A 3BDFA 5DLVA 3IGZB 3NKOA 2GSOA 1ELZA 2IUCB 1P49A 1Y6VA 3M7VA 1ELXA 3BDHA 3BDGB 5K4PA 5KXAA 2W5SA 3WBHA 5L0KA 3WAVA 1KHJA 3IDDA 4CXSA 2ANHA 3SZZA 3T00A 2W5QA 3NKNA 1KHKA 4KAYA 3NKPA 1EW9A 4N7TA 5IJSA 5C66A 5EGHA 4KJGA 4GTZA 2IFYA 1URAA 3Q3QA 1AJDA 1E3CP 3M8YA 4FDJA 1AUKA 5HRTA 1B8JA 4QAXA 3TG0A 5EGEA 3T01A 4KAVA 4UPKA 4LRFA 4MHXA 3WAXA 4ZG6A 5GRRA 4YR1A 1KH9A 2W8SA 4NWXA 2W5VA 1O99A 3BDGA 3NKMA 3UO0A 1KH4A 3M8ZA 3NKRA 1KH5A 2GA3A 2GSUA 4UOPA 4LR8A 5DLWA 4MY4A 1AJAA 1ALKA 3WAYA 3M8WA 1K7HA 4LR7A 4LRCA 2GSNA 4LR9A 3SZYA 2W5RA 4GTWA 1KHNA 3LXQA 3CMRA 5DLTA 1HQAA 4LQYA 5TJ3A 1HJKA 2W5WA 3UN5A 4CXKA 3A52A 3UN3A 5GOVA 1ELYA 1EJJA 2IUCA 4UPHA 3MK0A 2ZKTA 1HDHA 1SHNA 3KD8A 4UPLA 1SHQA 1E33P 3DYCA 4UOOA 1ED8A 4B56A 4LRBA 1E2SP 5L0BA 1AJCA 2VQRA 2GLQA 5IJQA 2D1GA 4KJDA 4NWJA 3TWZA 3B5QA 1ANJA 1O98A 1ANIA 1FSUA 4CYRA 5LRMA 4LRAA 1ALHA 3IGYB 3TX0A 2W5TA 1Y7AA 2QZUA 2X98A 1EQJA 2W5XA 2XRGA 1KH7A 1EI6A 4ZG9A 2XR9A 5INHA 4ZGAA 3NKQA 5LRNA 3UNYA 4UPIA 5AJ9A 1ALJA 4LRDA 4TN0A 1ZEDA 4MIVA 1N2KA
chains in the Genus database with same CATH topology
1ZEBA 4GTYA 4UORA 3WAWA 2RH6A 3MK2A 3DPCA 4LR2A 1EW2A 2W8DA 1ZEFA 1AJBA 4LREA 1URBA 1N2LA 4FDIA 1E1ZP 1ALIA 4KM4A 3MK1A 3UN2A 4CYSA 5LIAA 1ED9A 4GTXA 2G9YA 3NVLA 5L0EA 1KHLA 4ZG7A 3E2DA 3OT9A 3T02A 5LQQA 4CXUA 3ED4A 1EW8A 3BDFA 5DLVA 3IGZB 3NKOA 2GSOA 1ELZA 2IUCB 1P49A 1Y6VA 3M7VA 1ELXA 3BDHA 3BDGB 5K4PA 5KXAA 2W5SA 3WBHA 5L0KA 3WAVA 1KHJA 3IDDA 4CXSA 2ANHA 3SZZA 3T00A 2W5QA 3NKNA 1KHKA 4KAYA 3NKPA 1EW9A 4N7TA 5IJSA 5C66A 5EGHA 4KJGA 4GTZA 2IFYA 1URAA 3Q3QA 1AJDA 1E3CP 3M8YA 4FDJA 1AUKA 5HRTA 1B8JA 4QAXA 3TG0A 5EGEA 3T01A 4KAVA 4UPKA 4LRFA 4MHXA 3WAXA 4ZG6A 5GRRA 4YR1A 1KH9A 2W8SA 4NWXA 2W5VA 1O99A 3BDGA 3NKMA 3UO0A 1KH4A 3M8ZA 3NKRA 1KH5A 2GA3A 2GSUA 4UOPA 4LR8A 5DLWA 4MY4A 1AJAA 1ALKA 3WAYA 3M8WA 1K7HA 4LR7A 4LRCA 2GSNA 4LR9A 3SZYA 2W5RA 4GTWA 1KHNA 3LXQA 3CMRA 5DLTA 1HQAA 4LQYA 5TJ3A 1HJKA 2W5WA 3UN5A 4CXKA 3A52A 3UN3A 5GOVA 1ELYA 1EJJA 2IUCA 4UPHA 3MK0A 2ZKTA 1HDHA 1SHNA 3KD8A 4UPLA 1SHQA 1E33P 3DYCA 4UOOA 1ED8A 4B56A 4LRBA 1E2SP 5L0BA 1AJCA 2VQRA 2GLQA 5IJQA 2D1GA 4KJDA 4NWJA 3TWZA 3B5QA 1ANJA 1O98A 1ANIA 1FSUA 4CYRA 5LRMA 4LRAA 1ALHA 3IGYB 3TX0A 2W5TA 1Y7AA 2QZUA 2X98A 1EQJA 2W5XA 2XRGA 1KH7A 1EI6A 4ZG9A 2XR9A 5INHA 4ZGAA 3NKQA 5LRNA 3UNYA 4UPIA 5AJ9A 1ALJA 4LRDA 4TN0A 1ZEDA 4MIVA 1N2KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZEB A;  4GTY A;  4UOR A;  3WAW A;  2RH6 A;  3MK2 A;  3DPC A;  4LR2 A;  1EW2 A;  2W8D A;  1ZEF A;  1AJB A;  4LRE A;  1URB A;  1N2L A;  4FDI A;  1E1Z P;  1ALI A;  4KM4 A;  3MK1 A;  3UN2 A;  4CYS A;  5LIA A;  1ED9 A;  4GTX A;  2G9Y A;  3NVL A;  5L0E A;  1KHL A;  4ZG7 A;  3E2D A;  3OT9 A;  3T02 A;  5LQQ A;  4CXU A;  3ED4 A;  1EW8 A;  3BDF A;  5DLV A;  3IGZ B;  3NKO A;  2GSO A;  1ELZ A;  2IUC B;  1P49 A;  1Y6V A;  3M7V A;  1ELX A;  3BDH A;  3BDG B;  5K4P A;  5KXA A;  2W5S A;  3WBH A;  5L0K A;  3WAV A;  1KHJ A;  3IDD A;  4CXS A;  2ANH A;  3SZZ A;  3T00 A;  2W5Q A;  3NKN A;  1KHK A;  4KAY A;  3NKP A;  1EW9 A;  4N7T A;  5IJS A;  5C66 A;  5EGH A;  4KJG A;  4GTZ A;  2IFY A;  1URA A;  3Q3Q A;  1AJD A;  1E3C P;  3M8Y A;  4FDJ A;  1AUK A;  5HRT A;  1B8J A;  4QAX A;  3TG0 A;  5EGE A;  3T01 A;  4KAV A;  4UPK A;  4LRF A;  4MHX A;  3WAX A;  4ZG6 A;  5GRR A;  4YR1 A;  1KH9 A;  2W8S A;  4NWX A;  2W5V A;  1O99 A;  3BDG A;  3NKM A;  3UO0 A;  1KH4 A;  3M8Z A;  3NKR A;  1KH5 A;  2GA3 A;  2GSU A;  4UOP A;  4LR8 A;  5DLW A;  4MY4 A;  1AJA A;  1ALK A;  3WAY A;  3M8W A;  1K7H A;  4LR7 A;  4LRC A;  2GSN A;  4LR9 A;  3SZY A;  2W5R A;  4GTW A;  1KHN A;  3LXQ A;  3CMR A;  5DLT A;  1HQA A;  4LQY A;  5TJ3 A;  1HJK A;  2W5W A;  3UN5 A;  4CXK A;  3A52 A;  3UN3 A;  5GOV A;  1ELY A;  1EJJ A;  2IUC A;  4UPH A;  3MK0 A;  2ZKT A;  1HDH A;  1SHN A;  3KD8 A;  4UPL A;  1SHQ A;  1E33 P;  3DYC A;  4UOO A;  1ED8 A;  4B56 A;  4LRB A;  1E2S P;  5L0B A;  1AJC A;  2VQR A;  2GLQ A;  5IJQ A;  2D1G A;  4KJD A;  4NWJ A;  3TWZ A;  3B5Q A;  1ANJ A;  1O98 A;  1ANI A;  1FSU A;  4CYR A;  5LRM A;  4LRA A;  1ALH A;  3IGY B;  3TX0 A;  2W5T A;  1Y7A A;  2QZU A;  2X98 A;  1EQJ A;  2W5X A;  2XRG A;  1KH7 A;  1EI6 A;  4ZG9 A;  2XR9 A;  5INH A;  4ZGA A;  3NKQ A;  5LRN A;  3UNY A;  4UPI A;  5AJ9 A;  1ALJ A;  4LRD A;  4TN0 A;  1ZED A;  4MIV A;  1N2K A; 
#chains in the Genus database with same CATH topology
 1ZEB A;  4GTY A;  4UOR A;  3WAW A;  2RH6 A;  3MK2 A;  3DPC A;  4LR2 A;  1EW2 A;  2W8D A;  1ZEF A;  1AJB A;  4LRE A;  1URB A;  1N2L A;  4FDI A;  1E1Z P;  1ALI A;  4KM4 A;  3MK1 A;  3UN2 A;  4CYS A;  5LIA A;  1ED9 A;  4GTX A;  2G9Y A;  3NVL A;  5L0E A;  1KHL A;  4ZG7 A;  3E2D A;  3OT9 A;  3T02 A;  5LQQ A;  4CXU A;  3ED4 A;  1EW8 A;  3BDF A;  5DLV A;  3IGZ B;  3NKO A;  2GSO A;  1ELZ A;  2IUC B;  1P49 A;  1Y6V A;  3M7V A;  1ELX A;  3BDH A;  3BDG B;  5K4P A;  5KXA A;  2W5S A;  3WBH A;  5L0K A;  3WAV A;  1KHJ A;  3IDD A;  4CXS A;  2ANH A;  3SZZ A;  3T00 A;  2W5Q A;  3NKN A;  1KHK A;  4KAY A;  3NKP A;  1EW9 A;  4N7T A;  5IJS A;  5C66 A;  5EGH A;  4KJG A;  4GTZ A;  2IFY A;  1URA A;  3Q3Q A;  1AJD A;  1E3C P;  3M8Y A;  4FDJ A;  1AUK A;  5HRT A;  1B8J A;  4QAX A;  3TG0 A;  5EGE A;  3T01 A;  4KAV A;  4UPK A;  4LRF A;  4MHX A;  3WAX A;  4ZG6 A;  5GRR A;  4YR1 A;  1KH9 A;  2W8S A;  4NWX A;  2W5V A;  1O99 A;  3BDG A;  3NKM A;  3UO0 A;  1KH4 A;  3M8Z A;  3NKR A;  1KH5 A;  2GA3 A;  2GSU A;  4UOP A;  4LR8 A;  5DLW A;  4MY4 A;  1AJA A;  1ALK A;  3WAY A;  3M8W A;  1K7H A;  4LR7 A;  4LRC A;  2GSN A;  4LR9 A;  3SZY A;  2W5R A;  4GTW A;  1KHN A;  3LXQ A;  3CMR A;  5DLT A;  1HQA A;  4LQY A;  5TJ3 A;  1HJK A;  2W5W A;  3UN5 A;  4CXK A;  3A52 A;  3UN3 A;  5GOV A;  1ELY A;  1EJJ A;  2IUC A;  4UPH A;  3MK0 A;  2ZKT A;  1HDH A;  1SHN A;  3KD8 A;  4UPL A;  1SHQ A;  1E33 P;  3DYC A;  4UOO A;  1ED8 A;  4B56 A;  4LRB A;  1E2S P;  5L0B A;  1AJC A;  2VQR A;  2GLQ A;  5IJQ A;  2D1G A;  4KJD A;  4NWJ A;  3TWZ A;  3B5Q A;  1ANJ A;  1O98 A;  1ANI A;  1FSU A;  4CYR A;  5LRM A;  4LRA A;  1ALH A;  3IGY B;  3TX0 A;  2W5T A;  1Y7A A;  2QZU A;  2X98 A;  1EQJ A;  2W5X A;  2XRG A;  1KH7 A;  1EI6 A;  4ZG9 A;  2XR9 A;  5INH A;  4ZGA A;  3NKQ A;  5LRN A;  3UNY A;  4UPI A;  5AJ9 A;  1ALJ A;  4LRD A;  4TN0 A;  1ZED A;  4MIV A;  1N2K A; 
#chains in the Genus database with same CATH homology
 1ZEB A;  4GTY A;  4UOR A;  3WAW A;  2RH6 A;  3MK2 A;  3DPC A;  4LR2 A;  1EW2 A;  2W8D A;  1ZEF A;  1AJB A;  4LRE A;  1URB A;  1N2L A;  4FDI A;  1E1Z P;  1ALI A;  4KM4 A;  3MK1 A;  3UN2 A;  4CYS A;  5LIA A;  1ED9 A;  4GTX A;  2G9Y A;  3NVL A;  5L0E A;  1KHL A;  4ZG7 A;  3E2D A;  3OT9 A;  3T02 A;  5LQQ A;  4CXU A;  3ED4 A;  1EW8 A;  3BDF A;  5DLV A;  3IGZ B;  3NKO A;  2GSO A;  1ELZ A;  2IUC B;  1P49 A;  1Y6V A;  3M7V A;  1ELX A;  3BDH A;  3BDG B;  5K4P A;  5KXA A;  2W5S A;  3WBH A;  5L0K A;  3WAV A;  1KHJ A;  3IDD A;  4CXS A;  2ANH A;  3SZZ A;  3T00 A;  2W5Q A;  3NKN A;  1KHK A;  4KAY A;  3NKP A;  1EW9 A;  4N7T A;  5IJS A;  5C66 A;  5EGH A;  4KJG A;  4GTZ A;  2IFY A;  1URA A;  3Q3Q A;  1AJD A;  1E3C P;  3M8Y A;  4FDJ A;  1AUK A;  5HRT A;  1B8J A;  4QAX A;  3TG0 A;  5EGE A;  3T01 A;  4KAV A;  4UPK A;  4LRF A;  4MHX A;  3WAX A;  4ZG6 A;  5GRR A;  4YR1 A;  1KH9 A;  2W8S A;  4NWX A;  2W5V A;  1O99 A;  3BDG A;  3NKM A;  3UO0 A;  1KH4 A;  3M8Z A;  3NKR A;  1KH5 A;  2GA3 A;  2GSU A;  4UOP A;  4LR8 A;  5DLW A;  4MY4 A;  1AJA A;  1ALK A;  3WAY A;  3M8W A;  1K7H A;  4LR7 A;  4LRC A;  2GSN A;  4LR9 A;  3SZY A;  2W5R A;  4GTW A;  1KHN A;  3LXQ A;  3CMR A;  5DLT A;  1HQA A;  4LQY A;  5TJ3 A;  1HJK A;  2W5W A;  3UN5 A;  4CXK A;  3A52 A;  3UN3 A;  5GOV A;  1ELY A;  1EJJ A;  2IUC A;  4UPH A;  3MK0 A;  2ZKT A;  1HDH A;  1SHN A;  3KD8 A;  4UPL A;  1SHQ A;  1E33 P;  3DYC A;  4UOO A;  1ED8 A;  4B56 A;  4LRB A;  1E2S P;  5L0B A;  1AJC A;  2VQR A;  2GLQ A;  5IJQ A;  2D1G A;  4KJD A;  4NWJ A;  3TWZ A;  3B5Q A;  1ANJ A;  1O98 A;  1ANI A;  1FSU A;  4CYR A;  5LRM A;  4LRA A;  1ALH A;  3IGY B;  3TX0 A;  2W5T A;  1Y7A A;  2QZU A;  2X98 A;  1EQJ A;  2W5X A;  2XRG A;  1KH7 A;  1EI6 A;  4ZG9 A;  2XR9 A;  5INH A;  4ZGA A;  3NKQ A;  5LRN A;  3UNY A;  4UPI A;  5AJ9 A;  1ALJ A;  4LRD A;  4TN0 A;  1ZED A;  4MIV A;  1N2K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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