1EW8A

Alkaline phosphatase (e.c. 3.1.3.1) complex with phosphonoacetic acid
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
total genus 155
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew8A00
1KHKA 1Y7AA 2W5QA 3NKPA 2QZUA 1FSUA 3E2DA 4QAXA 1KH4A 1KH7A 5LRNA 1SHNA 5IJSA 1ALIA 4GTXA 2IUCB 3ED4A 5AJ9A 4MHXA 1Y6VA 2W5WA 1ED8A 5EGHA 4YR1A 4UORA 1P49A 2W5SA 2ZKTA 5K4PA 1EQJA 3MK2A 4GTWA 4CYSA 1ALHA 3TWZA 1ELZA 4LRDA 2D1GA 4KJGA 4UPHA 3DYCA 3NVLA 3WBHA 2GSNA 4MY4A 2G9YA 3LXQA 2W5TA 2VQRA 3IGYB 1ZEFA 5GRRA 4CXUA 2W8DA 2RH6A 4KJDA 3T01A 4CXKA 1N2LA 1B8JA 1K7HA 1URAA 3T02A 2GSUA 3B5QA 3CMRA 1KHJA 1AJAA 4LR2A 5LRMA 1HDHA 1KH9A 2GSOA 4MIVA 5DLTA 1E3CP 3UN2A 1SHQA 3M8ZA 3WAWA 1EI6A 4NWJA 4LR7A 3UN5A 2X98A 2W5XA 4UOPA 1ELXA 4KAVA 4KM4A 4GTZA 5L0KA 3UNYA 3WAVA 3MK1A 5LIAA 4LREA 4ZG6A 1E33P 3BDFA 3A52A 5TJ3A 3NKRA 4LRFA 3IDDA 1E2SP 1AJDA 1EW2A 1O98A 3KD8A 4LR8A 4NWXA 5LQQA 1ANIA 5GOVA 2ANHA 3BDGB 1KH5A 4ZG9A 4KAYA 2GLQA 5INHA 3UN3A 1HJKA 3M7VA 4CYRA 1KHNA 3T00A 3M8WA 4LR9A 5EGEA 1EW8A 3TG0A 1ZEDA 3NKMA 2XRGA 5IJQA 1O99A 4CXSA 4LRCA 4UOOA 1HQAA 5HRTA 5KXAA 1EJJA 3SZZA 5L0EA 4ZGAA 1KHLA 2GA3A 2XR9A 3Q3QA 4UPIA 3SZYA 1AJBA 3NKNA 4UPKA 5DLWA 4B56A 1URBA 3BDGA 4LQYA 4LRAA 1N2KA 4LRBA 3UO0A 5L0BA 3IGZB 3WAXA 1ALJA 3M8YA 4UPLA 3NKQA 2W5VA 2W8SA 1ALKA 4ZG7A 1E1ZP 2W5RA 3MK0A 3NKOA 1AUKA 4N7TA 5DLVA 1ELYA 3BDHA 1AJCA 4TN0A 3WAYA 3TX0A 2IUCA 5C66A 3OT9A 1ZEBA 1ED9A 3DPCA 4FDIA 1EW9A 4GTYA 2IFYA 1ANJA 4FDJA
chains in the Genus database with same CATH superfamily
1KHKA 1Y7AA 2W5QA 3NKPA 2QZUA 1FSUA 3E2DA 4QAXA 1KH4A 1KH7A 5LRNA 1SHNA 5IJSA 1ALIA 4GTXA 2IUCB 3ED4A 5AJ9A 4MHXA 1Y6VA 2W5WA 1ED8A 5EGHA 4YR1A 4UORA 1P49A 2W5SA 2ZKTA 5K4PA 1EQJA 3MK2A 4GTWA 4CYSA 1ALHA 3TWZA 1ELZA 4LRDA 2D1GA 4KJGA 4UPHA 3DYCA 3NVLA 3WBHA 2GSNA 4MY4A 2G9YA 3LXQA 2W5TA 2VQRA 3IGYB 1ZEFA 5GRRA 4CXUA 2W8DA 2RH6A 4KJDA 3T01A 4CXKA 1N2LA 1B8JA 1K7HA 1URAA 3T02A 2GSUA 3B5QA 3CMRA 1KHJA 1AJAA 4LR2A 5LRMA 1HDHA 1KH9A 2GSOA 4MIVA 5DLTA 1E3CP 3UN2A 1SHQA 3M8ZA 3WAWA 1EI6A 4NWJA 4LR7A 3UN5A 2X98A 2W5XA 4UOPA 1ELXA 4KAVA 4KM4A 4GTZA 5L0KA 3UNYA 3WAVA 3MK1A 5LIAA 4LREA 4ZG6A 1E33P 3BDFA 3A52A 5TJ3A 3NKRA 4LRFA 3IDDA 1E2SP 1AJDA 1EW2A 1O98A 3KD8A 4LR8A 4NWXA 5LQQA 1ANIA 5GOVA 2ANHA 3BDGB 1KH5A 4ZG9A 4KAYA 2GLQA 5INHA 3UN3A 1HJKA 3M7VA 4CYRA 1KHNA 3T00A 3M8WA 4LR9A 5EGEA 1EW8A 3TG0A 1ZEDA 3NKMA 2XRGA 5IJQA 1O99A 4CXSA 4LRCA 4UOOA 1HQAA 5HRTA 5KXAA 1EJJA 3SZZA 5L0EA 4ZGAA 1KHLA 2GA3A 2XR9A 3Q3QA 4UPIA 3SZYA 1AJBA 3NKNA 4UPKA 5DLWA 4B56A 1URBA 3BDGA 4LQYA 4LRAA 1N2KA 4LRBA 3UO0A 5L0BA 3IGZB 3WAXA 1ALJA 3M8YA 4UPLA 3NKQA 2W5VA 2W8SA 1ALKA 4ZG7A 1E1ZP 2W5RA 3MK0A 3NKOA 1AUKA 4N7TA 5DLVA 1ELYA 3BDHA 1AJCA 4TN0A 3WAYA 3TX0A 2IUCA 5C66A 3OT9A 1ZEBA 1ED9A 3DPCA 4FDIA 1EW9A 4GTYA 2IFYA 1ANJA 4FDJA
chains in the Genus database with same CATH topology
1KHKA 1Y7AA 2W5QA 3NKPA 2QZUA 1FSUA 3E2DA 4QAXA 1KH4A 1KH7A 5LRNA 1SHNA 5IJSA 1ALIA 4GTXA 2IUCB 3ED4A 5AJ9A 4MHXA 1Y6VA 2W5WA 1ED8A 5EGHA 4YR1A 4UORA 1P49A 2W5SA 2ZKTA 5K4PA 1EQJA 3MK2A 4GTWA 4CYSA 1ALHA 3TWZA 1ELZA 4LRDA 2D1GA 4KJGA 4UPHA 3DYCA 3NVLA 3WBHA 2GSNA 4MY4A 2G9YA 3LXQA 2W5TA 2VQRA 3IGYB 1ZEFA 5GRRA 4CXUA 2W8DA 2RH6A 4KJDA 3T01A 4CXKA 1N2LA 1B8JA 1K7HA 1URAA 3T02A 2GSUA 3B5QA 3CMRA 1KHJA 1AJAA 4LR2A 5LRMA 1HDHA 1KH9A 2GSOA 4MIVA 5DLTA 1E3CP 3UN2A 1SHQA 3M8ZA 3WAWA 1EI6A 4NWJA 4LR7A 3UN5A 2X98A 2W5XA 4UOPA 1ELXA 4KAVA 4KM4A 4GTZA 5L0KA 3UNYA 3WAVA 3MK1A 5LIAA 4LREA 4ZG6A 1E33P 3BDFA 3A52A 5TJ3A 3NKRA 4LRFA 3IDDA 1E2SP 1AJDA 1EW2A 1O98A 3KD8A 4LR8A 4NWXA 5LQQA 1ANIA 5GOVA 2ANHA 3BDGB 1KH5A 4ZG9A 4KAYA 2GLQA 5INHA 3UN3A 1HJKA 3M7VA 4CYRA 1KHNA 3T00A 3M8WA 4LR9A 5EGEA 1EW8A 3TG0A 1ZEDA 3NKMA 2XRGA 5IJQA 1O99A 4CXSA 4LRCA 4UOOA 1HQAA 5HRTA 5KXAA 1EJJA 3SZZA 5L0EA 4ZGAA 1KHLA 2GA3A 2XR9A 3Q3QA 4UPIA 3SZYA 1AJBA 3NKNA 4UPKA 5DLWA 4B56A 1URBA 3BDGA 4LQYA 4LRAA 1N2KA 4LRBA 3UO0A 5L0BA 3IGZB 3WAXA 1ALJA 3M8YA 4UPLA 3NKQA 2W5VA 2W8SA 1ALKA 4ZG7A 1E1ZP 2W5RA 3MK0A 3NKOA 1AUKA 4N7TA 5DLVA 1ELYA 3BDHA 1AJCA 4TN0A 3WAYA 3TX0A 2IUCA 5C66A 3OT9A 1ZEBA 1ED9A 3DPCA 4FDIA 1EW9A 4GTYA 2IFYA 1ANJA 4FDJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KHK A;  1Y7A A;  2W5Q A;  3NKP A;  2QZU A;  1FSU A;  3E2D A;  4QAX A;  1KH4 A;  1KH7 A;  5LRN A;  1SHN A;  5IJS A;  1ALI A;  4GTX A;  2IUC B;  3ED4 A;  5AJ9 A;  4MHX A;  1Y6V A;  2W5W A;  1ED8 A;  5EGH A;  4YR1 A;  4UOR A;  1P49 A;  2W5S A;  2ZKT A;  5K4P A;  1EQJ A;  3MK2 A;  4GTW A;  4CYS A;  1ALH A;  3TWZ A;  1ELZ A;  4LRD A;  2D1G A;  4KJG A;  4UPH A;  3DYC A;  3NVL A;  3WBH A;  2GSN A;  4MY4 A;  2G9Y A;  3LXQ A;  2W5T A;  2VQR A;  3IGY B;  1ZEF A;  5GRR A;  4CXU A;  2W8D A;  2RH6 A;  4KJD A;  3T01 A;  4CXK A;  1N2L A;  1B8J A;  1K7H A;  1URA A;  3T02 A;  2GSU A;  3B5Q A;  3CMR A;  1KHJ A;  1AJA A;  4LR2 A;  5LRM A;  1HDH A;  1KH9 A;  2GSO A;  4MIV A;  5DLT A;  1E3C P;  3UN2 A;  1SHQ A;  3M8Z A;  3WAW A;  1EI6 A;  4NWJ A;  4LR7 A;  3UN5 A;  2X98 A;  2W5X A;  4UOP A;  1ELX A;  4KAV A;  4KM4 A;  4GTZ A;  5L0K A;  3UNY A;  3WAV A;  3MK1 A;  5LIA A;  4LRE A;  4ZG6 A;  1E33 P;  3BDF A;  3A52 A;  5TJ3 A;  3NKR A;  4LRF A;  3IDD A;  1E2S P;  1AJD A;  1EW2 A;  1O98 A;  3KD8 A;  4LR8 A;  4NWX A;  5LQQ A;  1ANI A;  5GOV A;  2ANH A;  3BDG B;  1KH5 A;  4ZG9 A;  4KAY A;  2GLQ A;  5INH A;  3UN3 A;  1HJK A;  3M7V A;  4CYR A;  1KHN A;  3T00 A;  3M8W A;  4LR9 A;  5EGE A;  1EW8 A;  3TG0 A;  1ZED A;  3NKM A;  2XRG A;  5IJQ A;  1O99 A;  4CXS A;  4LRC A;  4UOO A;  1HQA A;  5HRT A;  5KXA A;  1EJJ A;  3SZZ A;  5L0E A;  4ZGA A;  1KHL A;  2GA3 A;  2XR9 A;  3Q3Q A;  4UPI A;  3SZY A;  1AJB A;  3NKN A;  4UPK A;  5DLW A;  4B56 A;  1URB A;  3BDG A;  4LQY A;  4LRA A;  1N2K A;  4LRB A;  3UO0 A;  5L0B A;  3IGZ B;  3WAX A;  1ALJ A;  3M8Y A;  4UPL A;  3NKQ A;  2W5V A;  2W8S A;  1ALK A;  4ZG7 A;  1E1Z P;  2W5R A;  3MK0 A;  3NKO A;  1AUK A;  4N7T A;  5DLV A;  1ELY A;  3BDH A;  1AJC A;  4TN0 A;  3WAY A;  3TX0 A;  2IUC A;  5C66 A;  3OT9 A;  1ZEB A;  1ED9 A;  3DPC A;  4FDI A;  1EW9 A;  4GTY A;  2IFY A;  1ANJ A;  4FDJ A; 
#chains in the Genus database with same CATH topology
 1KHK A;  1Y7A A;  2W5Q A;  3NKP A;  2QZU A;  1FSU A;  3E2D A;  4QAX A;  1KH4 A;  1KH7 A;  5LRN A;  1SHN A;  5IJS A;  1ALI A;  4GTX A;  2IUC B;  3ED4 A;  5AJ9 A;  4MHX A;  1Y6V A;  2W5W A;  1ED8 A;  5EGH A;  4YR1 A;  4UOR A;  1P49 A;  2W5S A;  2ZKT A;  5K4P A;  1EQJ A;  3MK2 A;  4GTW A;  4CYS A;  1ALH A;  3TWZ A;  1ELZ A;  4LRD A;  2D1G A;  4KJG A;  4UPH A;  3DYC A;  3NVL A;  3WBH A;  2GSN A;  4MY4 A;  2G9Y A;  3LXQ A;  2W5T A;  2VQR A;  3IGY B;  1ZEF A;  5GRR A;  4CXU A;  2W8D A;  2RH6 A;  4KJD A;  3T01 A;  4CXK A;  1N2L A;  1B8J A;  1K7H A;  1URA A;  3T02 A;  2GSU A;  3B5Q A;  3CMR A;  1KHJ A;  1AJA A;  4LR2 A;  5LRM A;  1HDH A;  1KH9 A;  2GSO A;  4MIV A;  5DLT A;  1E3C P;  3UN2 A;  1SHQ A;  3M8Z A;  3WAW A;  1EI6 A;  4NWJ A;  4LR7 A;  3UN5 A;  2X98 A;  2W5X A;  4UOP A;  1ELX A;  4KAV A;  4KM4 A;  4GTZ A;  5L0K A;  3UNY A;  3WAV A;  3MK1 A;  5LIA A;  4LRE A;  4ZG6 A;  1E33 P;  3BDF A;  3A52 A;  5TJ3 A;  3NKR A;  4LRF A;  3IDD A;  1E2S P;  1AJD A;  1EW2 A;  1O98 A;  3KD8 A;  4LR8 A;  4NWX A;  5LQQ A;  1ANI A;  5GOV A;  2ANH A;  3BDG B;  1KH5 A;  4ZG9 A;  4KAY A;  2GLQ A;  5INH A;  3UN3 A;  1HJK A;  3M7V A;  4CYR A;  1KHN A;  3T00 A;  3M8W A;  4LR9 A;  5EGE A;  1EW8 A;  3TG0 A;  1ZED A;  3NKM A;  2XRG A;  5IJQ A;  1O99 A;  4CXS A;  4LRC A;  4UOO A;  1HQA A;  5HRT A;  5KXA A;  1EJJ A;  3SZZ A;  5L0E A;  4ZGA A;  1KHL A;  2GA3 A;  2XR9 A;  3Q3Q A;  4UPI A;  3SZY A;  1AJB A;  3NKN A;  4UPK A;  5DLW A;  4B56 A;  1URB A;  3BDG A;  4LQY A;  4LRA A;  1N2K A;  4LRB A;  3UO0 A;  5L0B A;  3IGZ B;  3WAX A;  1ALJ A;  3M8Y A;  4UPL A;  3NKQ A;  2W5V A;  2W8S A;  1ALK A;  4ZG7 A;  1E1Z P;  2W5R A;  3MK0 A;  3NKO A;  1AUK A;  4N7T A;  5DLV A;  1ELY A;  3BDH A;  1AJC A;  4TN0 A;  3WAY A;  3TX0 A;  2IUC A;  5C66 A;  3OT9 A;  1ZEB A;  1ED9 A;  3DPC A;  4FDI A;  1EW9 A;  4GTY A;  2IFY A;  1ANJ A;  4FDJ A; 
#chains in the Genus database with same CATH homology
 1KHK A;  1Y7A A;  2W5Q A;  3NKP A;  2QZU A;  1FSU A;  3E2D A;  4QAX A;  1KH4 A;  1KH7 A;  5LRN A;  1SHN A;  5IJS A;  1ALI A;  4GTX A;  2IUC B;  3ED4 A;  5AJ9 A;  4MHX A;  1Y6V A;  2W5W A;  1ED8 A;  5EGH A;  4YR1 A;  4UOR A;  1P49 A;  2W5S A;  2ZKT A;  5K4P A;  1EQJ A;  3MK2 A;  4GTW A;  4CYS A;  1ALH A;  3TWZ A;  1ELZ A;  4LRD A;  2D1G A;  4KJG A;  4UPH A;  3DYC A;  3NVL A;  3WBH A;  2GSN A;  4MY4 A;  2G9Y A;  3LXQ A;  2W5T A;  2VQR A;  3IGY B;  1ZEF A;  5GRR A;  4CXU A;  2W8D A;  2RH6 A;  4KJD A;  3T01 A;  4CXK A;  1N2L A;  1B8J A;  1K7H A;  1URA A;  3T02 A;  2GSU A;  3B5Q A;  3CMR A;  1KHJ A;  1AJA A;  4LR2 A;  5LRM A;  1HDH A;  1KH9 A;  2GSO A;  4MIV A;  5DLT A;  1E3C P;  3UN2 A;  1SHQ A;  3M8Z A;  3WAW A;  1EI6 A;  4NWJ A;  4LR7 A;  3UN5 A;  2X98 A;  2W5X A;  4UOP A;  1ELX A;  4KAV A;  4KM4 A;  4GTZ A;  5L0K A;  3UNY A;  3WAV A;  3MK1 A;  5LIA A;  4LRE A;  4ZG6 A;  1E33 P;  3BDF A;  3A52 A;  5TJ3 A;  3NKR A;  4LRF A;  3IDD A;  1E2S P;  1AJD A;  1EW2 A;  1O98 A;  3KD8 A;  4LR8 A;  4NWX A;  5LQQ A;  1ANI A;  5GOV A;  2ANH A;  3BDG B;  1KH5 A;  4ZG9 A;  4KAY A;  2GLQ A;  5INH A;  3UN3 A;  1HJK A;  3M7V A;  4CYR A;  1KHN A;  3T00 A;  3M8W A;  4LR9 A;  5EGE A;  1EW8 A;  3TG0 A;  1ZED A;  3NKM A;  2XRG A;  5IJQ A;  1O99 A;  4CXS A;  4LRC A;  4UOO A;  1HQA A;  5HRT A;  5KXA A;  1EJJ A;  3SZZ A;  5L0E A;  4ZGA A;  1KHL A;  2GA3 A;  2XR9 A;  3Q3Q A;  4UPI A;  3SZY A;  1AJB A;  3NKN A;  4UPK A;  5DLW A;  4B56 A;  1URB A;  3BDG A;  4LQY A;  4LRA A;  1N2K A;  4LRB A;  3UO0 A;  5L0B A;  3IGZ B;  3WAX A;  1ALJ A;  3M8Y A;  4UPL A;  3NKQ A;  2W5V A;  2W8S A;  1ALK A;  4ZG7 A;  1E1Z P;  2W5R A;  3MK0 A;  3NKO A;  1AUK A;  4N7T A;  5DLV A;  1ELY A;  3BDH A;  1AJC A;  4TN0 A;  3WAY A;  3TX0 A;  2IUC A;  5C66 A;  3OT9 A;  1ZEB A;  1ED9 A;  3DPC A;  4FDI A;  1EW9 A;  4GTY A;  2IFY A;  1ANJ A;  4FDJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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