1EW8A

Alkaline phosphatase (e.c. 3.1.3.1) complex with phosphonoacetic acid
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 155
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew8A00
1ED8A 3NKNA 1E2SP 2QZUA 2XR9A 1N2LA 4FDIA 4LRCA 1KHNA 3T02A 1Y6VA 4FDJA 3SZZA 5K4PA 3BDFA 5LIAA 3OT9A 1E3CP 3KD8A 5GRRA 4UORA 1B8JA 1ZEBA 3UN2A 2GLQA 2W8DA 2RH6A 1FSUA 4YR1A 3M8YA 4LRDA 4LQYA 3M8WA 1KHJA 1URAA 1HDHA 3NKMA 2ANHA 4LRFA 3WAYA 1ELXA 4CXKA 1ELZA 3NKOA 5DLWA 4UPLA 4UOPA 3UN3A 3CMRA 4UPHA 5LRNA 3NKQA 4CXSA 5HRTA 2W5VA 3LXQA 1AJDA 1O99A 2W8SA 1EI6A 2GSOA 2ZKTA 3Q3QA 3WAVA 1ANJA 2IFYA 3T00A 4CYSA 4LR8A 3NVLA 4LR2A 1EW9A 4MIVA 2XRGA 1KH7A 3M8ZA 3IDDA 4KJDA 2W5WA 4GTWA 4CXUA 3MK2A 5DLVA 2VQRA 5EGEA 5DLTA 3UO0A 1ALIA 1EW8A 4B56A 1AJAA 5IJSA 1URBA 1ALJA 4LR9A 1AJCA 1KH9A 5GOVA 4GTZA 4N7TA 2GSUA 2X98A 3MK0A 1P49A 1EJJA 3E2DA 1Y7AA 1ED9A 4LR7A 1KHKA 1HQAA 5IJQA 3A52A 1HJKA 4MHXA 4TN0A 4LREA 1SHQA 4MY4A 4ZGAA 3WBHA 2D1GA 2W5XA 3UN5A 3UNYA 3NKRA 3DPCA 2W5TA 2GA3A 2W5QA 3BDGB 1ZEDA 1ELYA 2IUCB 4LRBA 1ANIA 2IUCA 4UPIA 4KAVA 1ZEFA 2GSNA 5TJ3A 2G9YA 3TG0A 1ALKA 1O98A 4KJGA 5LRMA 4ZG6A 3ED4A 5EGHA 1AJBA 3T01A 1KHLA 3B5QA 1N2KA 4GTXA 5L0EA 3WAWA 1EQJA 5LQQA 5L0BA 4NWJA 3WAXA 5AJ9A 5KXAA 5C66A 1AUKA 4ZG7A 2W5SA 4UOOA 3IGZB 1E33P 4NWXA 1KH5A 1E1ZP 1SHNA 4QAXA 3TX0A 2W5RA 4KAYA 3BDGA 1K7HA 3M7VA 4KM4A 1EW2A 3IGYB 3MK1A 3NKPA 3TWZA 5L0KA 1KH4A 4ZG9A 4LRAA 3DYCA 4UPKA 3BDHA 5INHA 4GTYA 4CYRA 3SZYA 1ALHA
chains in the Genus database with same CATH superfamily
1ED8A 3NKNA 1E2SP 2QZUA 2XR9A 1N2LA 4FDIA 4LRCA 1KHNA 3T02A 1Y6VA 4FDJA 3SZZA 5K4PA 3BDFA 5LIAA 3OT9A 1E3CP 3KD8A 5GRRA 4UORA 1B8JA 1ZEBA 3UN2A 2GLQA 2W8DA 2RH6A 1FSUA 4YR1A 3M8YA 4LRDA 4LQYA 3M8WA 1KHJA 1URAA 1HDHA 3NKMA 2ANHA 4LRFA 3WAYA 1ELXA 4CXKA 1ELZA 3NKOA 5DLWA 4UPLA 4UOPA 3UN3A 3CMRA 4UPHA 5LRNA 3NKQA 4CXSA 5HRTA 2W5VA 3LXQA 1AJDA 1O99A 2W8SA 1EI6A 2GSOA 2ZKTA 3Q3QA 3WAVA 1ANJA 2IFYA 3T00A 4CYSA 4LR8A 3NVLA 4LR2A 1EW9A 4MIVA 2XRGA 1KH7A 3M8ZA 3IDDA 4KJDA 2W5WA 4GTWA 4CXUA 3MK2A 5DLVA 2VQRA 5EGEA 5DLTA 3UO0A 1ALIA 1EW8A 4B56A 1AJAA 5IJSA 1URBA 1ALJA 4LR9A 1AJCA 1KH9A 5GOVA 4GTZA 4N7TA 2GSUA 2X98A 3MK0A 1P49A 1EJJA 3E2DA 1Y7AA 1ED9A 4LR7A 1KHKA 1HQAA 5IJQA 3A52A 1HJKA 4MHXA 4TN0A 4LREA 1SHQA 4MY4A 4ZGAA 3WBHA 2D1GA 2W5XA 3UN5A 3UNYA 3NKRA 3DPCA 2W5TA 2GA3A 2W5QA 3BDGB 1ZEDA 1ELYA 2IUCB 4LRBA 1ANIA 2IUCA 4UPIA 4KAVA 1ZEFA 2GSNA 5TJ3A 2G9YA 3TG0A 1ALKA 1O98A 4KJGA 5LRMA 4ZG6A 3ED4A 5EGHA 1AJBA 3T01A 1KHLA 3B5QA 1N2KA 4GTXA 5L0EA 3WAWA 1EQJA 5LQQA 5L0BA 4NWJA 3WAXA 5AJ9A 5KXAA 5C66A 1AUKA 4ZG7A 2W5SA 4UOOA 3IGZB 1E33P 4NWXA 1KH5A 1E1ZP 1SHNA 4QAXA 3TX0A 2W5RA 4KAYA 3BDGA 1K7HA 3M7VA 4KM4A 1EW2A 3IGYB 3MK1A 3NKPA 3TWZA 5L0KA 1KH4A 4ZG9A 4LRAA 3DYCA 4UPKA 3BDHA 5INHA 4GTYA 4CYRA 3SZYA 1ALHA
chains in the Genus database with same CATH topology
1ED8A 3NKNA 1E2SP 2QZUA 2XR9A 1N2LA 4FDIA 4LRCA 1KHNA 3T02A 1Y6VA 4FDJA 3SZZA 5K4PA 3BDFA 5LIAA 3OT9A 1E3CP 3KD8A 5GRRA 4UORA 1B8JA 1ZEBA 3UN2A 2GLQA 2W8DA 2RH6A 1FSUA 4YR1A 3M8YA 4LRDA 4LQYA 3M8WA 1KHJA 1URAA 1HDHA 3NKMA 2ANHA 4LRFA 3WAYA 1ELXA 4CXKA 1ELZA 3NKOA 5DLWA 4UPLA 4UOPA 3UN3A 3CMRA 4UPHA 5LRNA 3NKQA 4CXSA 5HRTA 2W5VA 3LXQA 1AJDA 1O99A 2W8SA 1EI6A 2GSOA 2ZKTA 3Q3QA 3WAVA 1ANJA 2IFYA 3T00A 4CYSA 4LR8A 3NVLA 4LR2A 1EW9A 4MIVA 2XRGA 1KH7A 3M8ZA 3IDDA 4KJDA 2W5WA 4GTWA 4CXUA 3MK2A 5DLVA 2VQRA 5EGEA 5DLTA 3UO0A 1ALIA 1EW8A 4B56A 1AJAA 5IJSA 1URBA 1ALJA 4LR9A 1AJCA 1KH9A 5GOVA 4GTZA 4N7TA 2GSUA 2X98A 3MK0A 1P49A 1EJJA 3E2DA 1Y7AA 1ED9A 4LR7A 1KHKA 1HQAA 5IJQA 3A52A 1HJKA 4MHXA 4TN0A 4LREA 1SHQA 4MY4A 4ZGAA 3WBHA 2D1GA 2W5XA 3UN5A 3UNYA 3NKRA 3DPCA 2W5TA 2GA3A 2W5QA 3BDGB 1ZEDA 1ELYA 2IUCB 4LRBA 1ANIA 2IUCA 4UPIA 4KAVA 1ZEFA 2GSNA 5TJ3A 2G9YA 3TG0A 1ALKA 1O98A 4KJGA 5LRMA 4ZG6A 3ED4A 5EGHA 1AJBA 3T01A 1KHLA 3B5QA 1N2KA 4GTXA 5L0EA 3WAWA 1EQJA 5LQQA 5L0BA 4NWJA 3WAXA 5AJ9A 5KXAA 5C66A 1AUKA 4ZG7A 2W5SA 4UOOA 3IGZB 1E33P 4NWXA 1KH5A 1E1ZP 1SHNA 4QAXA 3TX0A 2W5RA 4KAYA 3BDGA 1K7HA 3M7VA 4KM4A 1EW2A 3IGYB 3MK1A 3NKPA 3TWZA 5L0KA 1KH4A 4ZG9A 4LRAA 3DYCA 4UPKA 3BDHA 5INHA 4GTYA 4CYRA 3SZYA 1ALHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ED8 A;  3NKN A;  1E2S P;  2QZU A;  2XR9 A;  1N2L A;  4FDI A;  4LRC A;  1KHN A;  3T02 A;  1Y6V A;  4FDJ A;  3SZZ A;  5K4P A;  3BDF A;  5LIA A;  3OT9 A;  1E3C P;  3KD8 A;  5GRR A;  4UOR A;  1B8J A;  1ZEB A;  3UN2 A;  2GLQ A;  2W8D A;  2RH6 A;  1FSU A;  4YR1 A;  3M8Y A;  4LRD A;  4LQY A;  3M8W A;  1KHJ A;  1URA A;  1HDH A;  3NKM A;  2ANH A;  4LRF A;  3WAY A;  1ELX A;  4CXK A;  1ELZ A;  3NKO A;  5DLW A;  4UPL A;  4UOP A;  3UN3 A;  3CMR A;  4UPH A;  5LRN A;  3NKQ A;  4CXS A;  5HRT A;  2W5V A;  3LXQ A;  1AJD A;  1O99 A;  2W8S A;  1EI6 A;  2GSO A;  2ZKT A;  3Q3Q A;  3WAV A;  1ANJ A;  2IFY A;  3T00 A;  4CYS A;  4LR8 A;  3NVL A;  4LR2 A;  1EW9 A;  4MIV A;  2XRG A;  1KH7 A;  3M8Z A;  3IDD A;  4KJD A;  2W5W A;  4GTW A;  4CXU A;  3MK2 A;  5DLV A;  2VQR A;  5EGE A;  5DLT A;  3UO0 A;  1ALI A;  1EW8 A;  4B56 A;  1AJA A;  5IJS A;  1URB A;  1ALJ A;  4LR9 A;  1AJC A;  1KH9 A;  5GOV A;  4GTZ A;  4N7T A;  2GSU A;  2X98 A;  3MK0 A;  1P49 A;  1EJJ A;  3E2D A;  1Y7A A;  1ED9 A;  4LR7 A;  1KHK A;  1HQA A;  5IJQ A;  3A52 A;  1HJK A;  4MHX A;  4TN0 A;  4LRE A;  1SHQ A;  4MY4 A;  4ZGA A;  3WBH A;  2D1G A;  2W5X A;  3UN5 A;  3UNY A;  3NKR A;  3DPC A;  2W5T A;  2GA3 A;  2W5Q A;  3BDG B;  1ZED A;  1ELY A;  2IUC B;  4LRB A;  1ANI A;  2IUC A;  4UPI A;  4KAV A;  1ZEF A;  2GSN A;  5TJ3 A;  2G9Y A;  3TG0 A;  1ALK A;  1O98 A;  4KJG A;  5LRM A;  4ZG6 A;  3ED4 A;  5EGH A;  1AJB A;  3T01 A;  1KHL A;  3B5Q A;  1N2K A;  4GTX A;  5L0E A;  3WAW A;  1EQJ A;  5LQQ A;  5L0B A;  4NWJ A;  3WAX A;  5AJ9 A;  5KXA A;  5C66 A;  1AUK A;  4ZG7 A;  2W5S A;  4UOO A;  3IGZ B;  1E33 P;  4NWX A;  1KH5 A;  1E1Z P;  1SHN A;  4QAX A;  3TX0 A;  2W5R A;  4KAY A;  3BDG A;  1K7H A;  3M7V A;  4KM4 A;  1EW2 A;  3IGY B;  3MK1 A;  3NKP A;  3TWZ A;  5L0K A;  1KH4 A;  4ZG9 A;  4LRA A;  3DYC A;  4UPK A;  3BDH A;  5INH A;  4GTY A;  4CYR A;  3SZY A;  1ALH A; 
#chains in the Genus database with same CATH topology
 1ED8 A;  3NKN A;  1E2S P;  2QZU A;  2XR9 A;  1N2L A;  4FDI A;  4LRC A;  1KHN A;  3T02 A;  1Y6V A;  4FDJ A;  3SZZ A;  5K4P A;  3BDF A;  5LIA A;  3OT9 A;  1E3C P;  3KD8 A;  5GRR A;  4UOR A;  1B8J A;  1ZEB A;  3UN2 A;  2GLQ A;  2W8D A;  2RH6 A;  1FSU A;  4YR1 A;  3M8Y A;  4LRD A;  4LQY A;  3M8W A;  1KHJ A;  1URA A;  1HDH A;  3NKM A;  2ANH A;  4LRF A;  3WAY A;  1ELX A;  4CXK A;  1ELZ A;  3NKO A;  5DLW A;  4UPL A;  4UOP A;  3UN3 A;  3CMR A;  4UPH A;  5LRN A;  3NKQ A;  4CXS A;  5HRT A;  2W5V A;  3LXQ A;  1AJD A;  1O99 A;  2W8S A;  1EI6 A;  2GSO A;  2ZKT A;  3Q3Q A;  3WAV A;  1ANJ A;  2IFY A;  3T00 A;  4CYS A;  4LR8 A;  3NVL A;  4LR2 A;  1EW9 A;  4MIV A;  2XRG A;  1KH7 A;  3M8Z A;  3IDD A;  4KJD A;  2W5W A;  4GTW A;  4CXU A;  3MK2 A;  5DLV A;  2VQR A;  5EGE A;  5DLT A;  3UO0 A;  1ALI A;  1EW8 A;  4B56 A;  1AJA A;  5IJS A;  1URB A;  1ALJ A;  4LR9 A;  1AJC A;  1KH9 A;  5GOV A;  4GTZ A;  4N7T A;  2GSU A;  2X98 A;  3MK0 A;  1P49 A;  1EJJ A;  3E2D A;  1Y7A A;  1ED9 A;  4LR7 A;  1KHK A;  1HQA A;  5IJQ A;  3A52 A;  1HJK A;  4MHX A;  4TN0 A;  4LRE A;  1SHQ A;  4MY4 A;  4ZGA A;  3WBH A;  2D1G A;  2W5X A;  3UN5 A;  3UNY A;  3NKR A;  3DPC A;  2W5T A;  2GA3 A;  2W5Q A;  3BDG B;  1ZED A;  1ELY A;  2IUC B;  4LRB A;  1ANI A;  2IUC A;  4UPI A;  4KAV A;  1ZEF A;  2GSN A;  5TJ3 A;  2G9Y A;  3TG0 A;  1ALK A;  1O98 A;  4KJG A;  5LRM A;  4ZG6 A;  3ED4 A;  5EGH A;  1AJB A;  3T01 A;  1KHL A;  3B5Q A;  1N2K A;  4GTX A;  5L0E A;  3WAW A;  1EQJ A;  5LQQ A;  5L0B A;  4NWJ A;  3WAX A;  5AJ9 A;  5KXA A;  5C66 A;  1AUK A;  4ZG7 A;  2W5S A;  4UOO A;  3IGZ B;  1E33 P;  4NWX A;  1KH5 A;  1E1Z P;  1SHN A;  4QAX A;  3TX0 A;  2W5R A;  4KAY A;  3BDG A;  1K7H A;  3M7V A;  4KM4 A;  1EW2 A;  3IGY B;  3MK1 A;  3NKP A;  3TWZ A;  5L0K A;  1KH4 A;  4ZG9 A;  4LRA A;  3DYC A;  4UPK A;  3BDH A;  5INH A;  4GTY A;  4CYR A;  3SZY A;  1ALH A; 
#chains in the Genus database with same CATH homology
 1ED8 A;  3NKN A;  1E2S P;  2QZU A;  2XR9 A;  1N2L A;  4FDI A;  4LRC A;  1KHN A;  3T02 A;  1Y6V A;  4FDJ A;  3SZZ A;  5K4P A;  3BDF A;  5LIA A;  3OT9 A;  1E3C P;  3KD8 A;  5GRR A;  4UOR A;  1B8J A;  1ZEB A;  3UN2 A;  2GLQ A;  2W8D A;  2RH6 A;  1FSU A;  4YR1 A;  3M8Y A;  4LRD A;  4LQY A;  3M8W A;  1KHJ A;  1URA A;  1HDH A;  3NKM A;  2ANH A;  4LRF A;  3WAY A;  1ELX A;  4CXK A;  1ELZ A;  3NKO A;  5DLW A;  4UPL A;  4UOP A;  3UN3 A;  3CMR A;  4UPH A;  5LRN A;  3NKQ A;  4CXS A;  5HRT A;  2W5V A;  3LXQ A;  1AJD A;  1O99 A;  2W8S A;  1EI6 A;  2GSO A;  2ZKT A;  3Q3Q A;  3WAV A;  1ANJ A;  2IFY A;  3T00 A;  4CYS A;  4LR8 A;  3NVL A;  4LR2 A;  1EW9 A;  4MIV A;  2XRG A;  1KH7 A;  3M8Z A;  3IDD A;  4KJD A;  2W5W A;  4GTW A;  4CXU A;  3MK2 A;  5DLV A;  2VQR A;  5EGE A;  5DLT A;  3UO0 A;  1ALI A;  1EW8 A;  4B56 A;  1AJA A;  5IJS A;  1URB A;  1ALJ A;  4LR9 A;  1AJC A;  1KH9 A;  5GOV A;  4GTZ A;  4N7T A;  2GSU A;  2X98 A;  3MK0 A;  1P49 A;  1EJJ A;  3E2D A;  1Y7A A;  1ED9 A;  4LR7 A;  1KHK A;  1HQA A;  5IJQ A;  3A52 A;  1HJK A;  4MHX A;  4TN0 A;  4LRE A;  1SHQ A;  4MY4 A;  4ZGA A;  3WBH A;  2D1G A;  2W5X A;  3UN5 A;  3UNY A;  3NKR A;  3DPC A;  2W5T A;  2GA3 A;  2W5Q A;  3BDG B;  1ZED A;  1ELY A;  2IUC B;  4LRB A;  1ANI A;  2IUC A;  4UPI A;  4KAV A;  1ZEF A;  2GSN A;  5TJ3 A;  2G9Y A;  3TG0 A;  1ALK A;  1O98 A;  4KJG A;  5LRM A;  4ZG6 A;  3ED4 A;  5EGH A;  1AJB A;  3T01 A;  1KHL A;  3B5Q A;  1N2K A;  4GTX A;  5L0E A;  3WAW A;  1EQJ A;  5LQQ A;  5L0B A;  4NWJ A;  3WAX A;  5AJ9 A;  5KXA A;  5C66 A;  1AUK A;  4ZG7 A;  2W5S A;  4UOO A;  3IGZ B;  1E33 P;  4NWX A;  1KH5 A;  1E1Z P;  1SHN A;  4QAX A;  3TX0 A;  2W5R A;  4KAY A;  3BDG A;  1K7H A;  3M7V A;  4KM4 A;  1EW2 A;  3IGY B;  3MK1 A;  3NKP A;  3TWZ A;  5L0K A;  1KH4 A;  4ZG9 A;  4LRA A;  3DYC A;  4UPK A;  3BDH A;  5INH A;  4GTY A;  4CYR A;  3SZY A;  1ALH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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