1EW8A

Alkaline phosphatase (e.c. 3.1.3.1) complex with phosphonoacetic acid
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
total genus 155
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew8A00
1AJCA 5LIAA 1E2SP 4LR9A 1B8JA 1URBA 3TX0A 5DLWA 2IUCB 5DLVA 3UNYA 1EQJA 2ZKTA 1ED9A 1Y7AA 2ANHA 3WAWA 1KH7A 3M7VA 3MK2A 3NKQA 1KHKA 4MHXA 1E3CP 4GTYA 4UOOA 4KAVA 4GTWA 4KM4A 1Y6VA 4LRFA 5KXAA 3IGZB 4UPLA 5HRTA 1HDHA 4YR1A 5L0BA 1ANIA 2IUCA 4UORA 5LRNA 5AJ9A 1P49A 3CMRA 4KAYA 4LRBA 3NKRA 3UN3A 1KH4A 3M8ZA 3T00A 1ANJA 1KH5A 5LQQA 3SZYA 3SZZA 4CYRA 3WAVA 1EW9A 1HQAA 4GTXA 1E33P 4KJDA 4UPHA 1ZEFA 4FDJA 5K4PA 4LR2A 4UOPA 4LR8A 3NVLA 1ALKA 1KHLA 3M8WA 5DLTA 3DPCA 2RH6A 4LQYA 3DYCA 3BDGB 4NWJA 4CXUA 1SHQA 5EGEA 5TJ3A 2W5RA 4KJGA 3A52A 5C66A 3E2DA 4QAXA 3UN2A 2W5WA 4GTZA 5GOVA 3WAYA 3ED4A 2W5XA 3TWZA 2GSOA 1AJAA 5GRRA 3LXQA 1AJBA 1ED8A 5EGHA 1ALJA 1EJJA 3BDFA 4ZG6A 1EW8A 3UO0A 4LRAA 1ELXA 1E1ZP 1FSUA 1SHNA 4ZGAA 2D1GA 1ZEBA 2W5TA 4CYSA 1N2KA 3NKNA 2XR9A 1HJKA 1EI6A 3B5QA 3NKPA 2W8DA 4UPKA 1O99A 2GSUA 4ZG9A 2GLQA 2XRGA 1AJDA 1N2LA 1URAA 3T02A 2X98A 3IDDA 3OT9A 3MK0A 5LRMA 4B56A 5IJSA 3WAXA 1ELYA 3WBHA 4CXKA 2W5SA 4UPIA 2QZUA 2W8SA 2GA3A 1EW2A 1AUKA 3T01A 2G9YA 4MY4A 3TG0A 5INHA 3NKOA 3BDHA 4FDIA 3IGYB 3Q3QA 2GSNA 4N7TA 5IJQA 1KH9A 4ZG7A 1ALIA 1K7HA 4LR7A 2W5VA 4LRDA 1ELZA 2IFYA 4NWXA 5L0KA 4TN0A 1KHJA 1O98A 1KHNA 4MIVA 3NKMA 3MK1A 1ALHA 4CXSA 5L0EA 1ZEDA 2W5QA 4LREA 3BDGA 3M8YA 4LRCA 2VQRA 3UN5A 3KD8A
chains in the Genus database with same CATH superfamily
1AJCA 5LIAA 1E2SP 4LR9A 1B8JA 1URBA 3TX0A 5DLWA 2IUCB 5DLVA 3UNYA 1EQJA 2ZKTA 1ED9A 1Y7AA 2ANHA 3WAWA 1KH7A 3M7VA 3MK2A 3NKQA 1KHKA 4MHXA 1E3CP 4GTYA 4UOOA 4KAVA 4GTWA 4KM4A 1Y6VA 4LRFA 5KXAA 3IGZB 4UPLA 5HRTA 1HDHA 4YR1A 5L0BA 1ANIA 2IUCA 4UORA 5LRNA 5AJ9A 1P49A 3CMRA 4KAYA 4LRBA 3NKRA 3UN3A 1KH4A 3M8ZA 3T00A 1ANJA 1KH5A 5LQQA 3SZYA 3SZZA 4CYRA 3WAVA 1EW9A 1HQAA 4GTXA 1E33P 4KJDA 4UPHA 1ZEFA 4FDJA 5K4PA 4LR2A 4UOPA 4LR8A 3NVLA 1ALKA 1KHLA 3M8WA 5DLTA 3DPCA 2RH6A 4LQYA 3DYCA 3BDGB 4NWJA 4CXUA 1SHQA 5EGEA 5TJ3A 2W5RA 4KJGA 3A52A 5C66A 3E2DA 4QAXA 3UN2A 2W5WA 4GTZA 5GOVA 3WAYA 3ED4A 2W5XA 3TWZA 2GSOA 1AJAA 5GRRA 3LXQA 1AJBA 1ED8A 5EGHA 1ALJA 1EJJA 3BDFA 4ZG6A 1EW8A 3UO0A 4LRAA 1ELXA 1E1ZP 1FSUA 1SHNA 4ZGAA 2D1GA 1ZEBA 2W5TA 4CYSA 1N2KA 3NKNA 2XR9A 1HJKA 1EI6A 3B5QA 3NKPA 2W8DA 4UPKA 1O99A 2GSUA 4ZG9A 2GLQA 2XRGA 1AJDA 1N2LA 1URAA 3T02A 2X98A 3IDDA 3OT9A 3MK0A 5LRMA 4B56A 5IJSA 3WAXA 1ELYA 3WBHA 4CXKA 2W5SA 4UPIA 2QZUA 2W8SA 2GA3A 1EW2A 1AUKA 3T01A 2G9YA 4MY4A 3TG0A 5INHA 3NKOA 3BDHA 4FDIA 3IGYB 3Q3QA 2GSNA 4N7TA 5IJQA 1KH9A 4ZG7A 1ALIA 1K7HA 4LR7A 2W5VA 4LRDA 1ELZA 2IFYA 4NWXA 5L0KA 4TN0A 1KHJA 1O98A 1KHNA 4MIVA 3NKMA 3MK1A 1ALHA 4CXSA 5L0EA 1ZEDA 2W5QA 4LREA 3BDGA 3M8YA 4LRCA 2VQRA 3UN5A 3KD8A
chains in the Genus database with same CATH topology
1AJCA 5LIAA 1E2SP 4LR9A 1B8JA 1URBA 3TX0A 5DLWA 2IUCB 5DLVA 3UNYA 1EQJA 2ZKTA 1ED9A 1Y7AA 2ANHA 3WAWA 1KH7A 3M7VA 3MK2A 3NKQA 1KHKA 4MHXA 1E3CP 4GTYA 4UOOA 4KAVA 4GTWA 4KM4A 1Y6VA 4LRFA 5KXAA 3IGZB 4UPLA 5HRTA 1HDHA 4YR1A 5L0BA 1ANIA 2IUCA 4UORA 5LRNA 5AJ9A 1P49A 3CMRA 4KAYA 4LRBA 3NKRA 3UN3A 1KH4A 3M8ZA 3T00A 1ANJA 1KH5A 5LQQA 3SZYA 3SZZA 4CYRA 3WAVA 1EW9A 1HQAA 4GTXA 1E33P 4KJDA 4UPHA 1ZEFA 4FDJA 5K4PA 4LR2A 4UOPA 4LR8A 3NVLA 1ALKA 1KHLA 3M8WA 5DLTA 3DPCA 2RH6A 4LQYA 3DYCA 3BDGB 4NWJA 4CXUA 1SHQA 5EGEA 5TJ3A 2W5RA 4KJGA 3A52A 5C66A 3E2DA 4QAXA 3UN2A 2W5WA 4GTZA 5GOVA 3WAYA 3ED4A 2W5XA 3TWZA 2GSOA 1AJAA 5GRRA 3LXQA 1AJBA 1ED8A 5EGHA 1ALJA 1EJJA 3BDFA 4ZG6A 1EW8A 3UO0A 4LRAA 1ELXA 1E1ZP 1FSUA 1SHNA 4ZGAA 2D1GA 1ZEBA 2W5TA 4CYSA 1N2KA 3NKNA 2XR9A 1HJKA 1EI6A 3B5QA 3NKPA 2W8DA 4UPKA 1O99A 2GSUA 4ZG9A 2GLQA 2XRGA 1AJDA 1N2LA 1URAA 3T02A 2X98A 3IDDA 3OT9A 3MK0A 5LRMA 4B56A 5IJSA 3WAXA 1ELYA 3WBHA 4CXKA 2W5SA 4UPIA 2QZUA 2W8SA 2GA3A 1EW2A 1AUKA 3T01A 2G9YA 4MY4A 3TG0A 5INHA 3NKOA 3BDHA 4FDIA 3IGYB 3Q3QA 2GSNA 4N7TA 5IJQA 1KH9A 4ZG7A 1ALIA 1K7HA 4LR7A 2W5VA 4LRDA 1ELZA 2IFYA 4NWXA 5L0KA 4TN0A 1KHJA 1O98A 1KHNA 4MIVA 3NKMA 3MK1A 1ALHA 4CXSA 5L0EA 1ZEDA 2W5QA 4LREA 3BDGA 3M8YA 4LRCA 2VQRA 3UN5A 3KD8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AJC A;  5LIA A;  1E2S P;  4LR9 A;  1B8J A;  1URB A;  3TX0 A;  5DLW A;  2IUC B;  5DLV A;  3UNY A;  1EQJ A;  2ZKT A;  1ED9 A;  1Y7A A;  2ANH A;  3WAW A;  1KH7 A;  3M7V A;  3MK2 A;  3NKQ A;  1KHK A;  4MHX A;  1E3C P;  4GTY A;  4UOO A;  4KAV A;  4GTW A;  4KM4 A;  1Y6V A;  4LRF A;  5KXA A;  3IGZ B;  4UPL A;  5HRT A;  1HDH A;  4YR1 A;  5L0B A;  1ANI A;  2IUC A;  4UOR A;  5LRN A;  5AJ9 A;  1P49 A;  3CMR A;  4KAY A;  4LRB A;  3NKR A;  3UN3 A;  1KH4 A;  3M8Z A;  3T00 A;  1ANJ A;  1KH5 A;  5LQQ A;  3SZY A;  3SZZ A;  4CYR A;  3WAV A;  1EW9 A;  1HQA A;  4GTX A;  1E33 P;  4KJD A;  4UPH A;  1ZEF A;  4FDJ A;  5K4P A;  4LR2 A;  4UOP A;  4LR8 A;  3NVL A;  1ALK A;  1KHL A;  3M8W A;  5DLT A;  3DPC A;  2RH6 A;  4LQY A;  3DYC A;  3BDG B;  4NWJ A;  4CXU A;  1SHQ A;  5EGE A;  5TJ3 A;  2W5R A;  4KJG A;  3A52 A;  5C66 A;  3E2D A;  4QAX A;  3UN2 A;  2W5W A;  4GTZ A;  5GOV A;  3WAY A;  3ED4 A;  2W5X A;  3TWZ A;  2GSO A;  1AJA A;  5GRR A;  3LXQ A;  1AJB A;  1ED8 A;  5EGH A;  1ALJ A;  1EJJ A;  3BDF A;  4ZG6 A;  1EW8 A;  3UO0 A;  4LRA A;  1ELX A;  1E1Z P;  1FSU A;  1SHN A;  4ZGA A;  2D1G A;  1ZEB A;  2W5T A;  4CYS A;  1N2K A;  3NKN A;  2XR9 A;  1HJK A;  1EI6 A;  3B5Q A;  3NKP A;  2W8D A;  4UPK A;  1O99 A;  2GSU A;  4ZG9 A;  2GLQ A;  2XRG A;  1AJD A;  1N2L A;  1URA A;  3T02 A;  2X98 A;  3IDD A;  3OT9 A;  3MK0 A;  5LRM A;  4B56 A;  5IJS A;  3WAX A;  1ELY A;  3WBH A;  4CXK A;  2W5S A;  4UPI A;  2QZU A;  2W8S A;  2GA3 A;  1EW2 A;  1AUK A;  3T01 A;  2G9Y A;  4MY4 A;  3TG0 A;  5INH A;  3NKO A;  3BDH A;  4FDI A;  3IGY B;  3Q3Q A;  2GSN A;  4N7T A;  5IJQ A;  1KH9 A;  4ZG7 A;  1ALI A;  1K7H A;  4LR7 A;  2W5V A;  4LRD A;  1ELZ A;  2IFY A;  4NWX A;  5L0K A;  4TN0 A;  1KHJ A;  1O98 A;  1KHN A;  4MIV A;  3NKM A;  3MK1 A;  1ALH A;  4CXS A;  5L0E A;  1ZED A;  2W5Q A;  4LRE A;  3BDG A;  3M8Y A;  4LRC A;  2VQR A;  3UN5 A;  3KD8 A; 
#chains in the Genus database with same CATH topology
 1AJC A;  5LIA A;  1E2S P;  4LR9 A;  1B8J A;  1URB A;  3TX0 A;  5DLW A;  2IUC B;  5DLV A;  3UNY A;  1EQJ A;  2ZKT A;  1ED9 A;  1Y7A A;  2ANH A;  3WAW A;  1KH7 A;  3M7V A;  3MK2 A;  3NKQ A;  1KHK A;  4MHX A;  1E3C P;  4GTY A;  4UOO A;  4KAV A;  4GTW A;  4KM4 A;  1Y6V A;  4LRF A;  5KXA A;  3IGZ B;  4UPL A;  5HRT A;  1HDH A;  4YR1 A;  5L0B A;  1ANI A;  2IUC A;  4UOR A;  5LRN A;  5AJ9 A;  1P49 A;  3CMR A;  4KAY A;  4LRB A;  3NKR A;  3UN3 A;  1KH4 A;  3M8Z A;  3T00 A;  1ANJ A;  1KH5 A;  5LQQ A;  3SZY A;  3SZZ A;  4CYR A;  3WAV A;  1EW9 A;  1HQA A;  4GTX A;  1E33 P;  4KJD A;  4UPH A;  1ZEF A;  4FDJ A;  5K4P A;  4LR2 A;  4UOP A;  4LR8 A;  3NVL A;  1ALK A;  1KHL A;  3M8W A;  5DLT A;  3DPC A;  2RH6 A;  4LQY A;  3DYC A;  3BDG B;  4NWJ A;  4CXU A;  1SHQ A;  5EGE A;  5TJ3 A;  2W5R A;  4KJG A;  3A52 A;  5C66 A;  3E2D A;  4QAX A;  3UN2 A;  2W5W A;  4GTZ A;  5GOV A;  3WAY A;  3ED4 A;  2W5X A;  3TWZ A;  2GSO A;  1AJA A;  5GRR A;  3LXQ A;  1AJB A;  1ED8 A;  5EGH A;  1ALJ A;  1EJJ A;  3BDF A;  4ZG6 A;  1EW8 A;  3UO0 A;  4LRA A;  1ELX A;  1E1Z P;  1FSU A;  1SHN A;  4ZGA A;  2D1G A;  1ZEB A;  2W5T A;  4CYS A;  1N2K A;  3NKN A;  2XR9 A;  1HJK A;  1EI6 A;  3B5Q A;  3NKP A;  2W8D A;  4UPK A;  1O99 A;  2GSU A;  4ZG9 A;  2GLQ A;  2XRG A;  1AJD A;  1N2L A;  1URA A;  3T02 A;  2X98 A;  3IDD A;  3OT9 A;  3MK0 A;  5LRM A;  4B56 A;  5IJS A;  3WAX A;  1ELY A;  3WBH A;  4CXK A;  2W5S A;  4UPI A;  2QZU A;  2W8S A;  2GA3 A;  1EW2 A;  1AUK A;  3T01 A;  2G9Y A;  4MY4 A;  3TG0 A;  5INH A;  3NKO A;  3BDH A;  4FDI A;  3IGY B;  3Q3Q A;  2GSN A;  4N7T A;  5IJQ A;  1KH9 A;  4ZG7 A;  1ALI A;  1K7H A;  4LR7 A;  2W5V A;  4LRD A;  1ELZ A;  2IFY A;  4NWX A;  5L0K A;  4TN0 A;  1KHJ A;  1O98 A;  1KHN A;  4MIV A;  3NKM A;  3MK1 A;  1ALH A;  4CXS A;  5L0E A;  1ZED A;  2W5Q A;  4LRE A;  3BDG A;  3M8Y A;  4LRC A;  2VQR A;  3UN5 A;  3KD8 A; 
#chains in the Genus database with same CATH homology
 1AJC A;  5LIA A;  1E2S P;  4LR9 A;  1B8J A;  1URB A;  3TX0 A;  5DLW A;  2IUC B;  5DLV A;  3UNY A;  1EQJ A;  2ZKT A;  1ED9 A;  1Y7A A;  2ANH A;  3WAW A;  1KH7 A;  3M7V A;  3MK2 A;  3NKQ A;  1KHK A;  4MHX A;  1E3C P;  4GTY A;  4UOO A;  4KAV A;  4GTW A;  4KM4 A;  1Y6V A;  4LRF A;  5KXA A;  3IGZ B;  4UPL A;  5HRT A;  1HDH A;  4YR1 A;  5L0B A;  1ANI A;  2IUC A;  4UOR A;  5LRN A;  5AJ9 A;  1P49 A;  3CMR A;  4KAY A;  4LRB A;  3NKR A;  3UN3 A;  1KH4 A;  3M8Z A;  3T00 A;  1ANJ A;  1KH5 A;  5LQQ A;  3SZY A;  3SZZ A;  4CYR A;  3WAV A;  1EW9 A;  1HQA A;  4GTX A;  1E33 P;  4KJD A;  4UPH A;  1ZEF A;  4FDJ A;  5K4P A;  4LR2 A;  4UOP A;  4LR8 A;  3NVL A;  1ALK A;  1KHL A;  3M8W A;  5DLT A;  3DPC A;  2RH6 A;  4LQY A;  3DYC A;  3BDG B;  4NWJ A;  4CXU A;  1SHQ A;  5EGE A;  5TJ3 A;  2W5R A;  4KJG A;  3A52 A;  5C66 A;  3E2D A;  4QAX A;  3UN2 A;  2W5W A;  4GTZ A;  5GOV A;  3WAY A;  3ED4 A;  2W5X A;  3TWZ A;  2GSO A;  1AJA A;  5GRR A;  3LXQ A;  1AJB A;  1ED8 A;  5EGH A;  1ALJ A;  1EJJ A;  3BDF A;  4ZG6 A;  1EW8 A;  3UO0 A;  4LRA A;  1ELX A;  1E1Z P;  1FSU A;  1SHN A;  4ZGA A;  2D1G A;  1ZEB A;  2W5T A;  4CYS A;  1N2K A;  3NKN A;  2XR9 A;  1HJK A;  1EI6 A;  3B5Q A;  3NKP A;  2W8D A;  4UPK A;  1O99 A;  2GSU A;  4ZG9 A;  2GLQ A;  2XRG A;  1AJD A;  1N2L A;  1URA A;  3T02 A;  2X98 A;  3IDD A;  3OT9 A;  3MK0 A;  5LRM A;  4B56 A;  5IJS A;  3WAX A;  1ELY A;  3WBH A;  4CXK A;  2W5S A;  4UPI A;  2QZU A;  2W8S A;  2GA3 A;  1EW2 A;  1AUK A;  3T01 A;  2G9Y A;  4MY4 A;  3TG0 A;  5INH A;  3NKO A;  3BDH A;  4FDI A;  3IGY B;  3Q3Q A;  2GSN A;  4N7T A;  5IJQ A;  1KH9 A;  4ZG7 A;  1ALI A;  1K7H A;  4LR7 A;  2W5V A;  4LRD A;  1ELZ A;  2IFY A;  4NWX A;  5L0K A;  4TN0 A;  1KHJ A;  1O98 A;  1KHN A;  4MIV A;  3NKM A;  3MK1 A;  1ALH A;  4CXS A;  5L0E A;  1ZED A;  2W5Q A;  4LRE A;  3BDG A;  3M8Y A;  4LRC A;  2VQR A;  3UN5 A;  3KD8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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