1EXTA

Extracellular domain of the 55kda tumor necrosis factor receptor. crystallized at ph3.7 in p 21 21 21.
Total Genus 29
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
160
structure length
160
Chain Sequence
SVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIEN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signalling protein
molecule keywords TUMOR NECROSIS FACTOR RECEPTOR
publication title Structures of the extracellular domain of the type I tumor necrosis factor receptor.
pubmed doi rcsb
source organism Homo sapiens
total genus 29
structure length 160
sequence length 160
chains with identical sequence B
ec nomenclature
pdb deposition date 1996-07-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1extA02
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1extA01
3URFZ 3QBQB 4MXWR 3ME2R 3K51B 4OD2S 3TJEF 1FT4A 3MI8D 4I9XC 3U3QA 3QO4A 1JMAB 3U3TA 3U3SA 1D4VA 2X10A 3ME4A 3U3VA 3IJ2X 4J6GC 2H9GR 4E4DR 5L36B 1ZA3R 4MSVB 1NCFA 3QD6R 3THMF 3MHDD 3ALQR 1TNRR 4BK4A 2HEYR 3MBWA 4N90R 4FHQA 4GIQR 4BK5A 5IHLA 1D0GR 5CIRE 3BUKC 4M4PA 4M4RA 5DMJA 1DU3A 3FL7A 3U3PA 3X3FA 1SG1X 4YN0A 4KGQC 1EXTA 5BNQR 4KGGC 4RSUD 3WVTA 2HEVR 2AW2B 2UWIA
chains in the Genus database with same CATH superfamily
3URFZ 3QBQB 4MXWR 3ME2R 2E4VA 3K51B 4OD2S 1FT4A 3MI8D 4I9XC 3TJEF 2E4UA 3U3QA 3QO4A 2E4YA 1JMAB 2QR6A 3U3TA 3U3SA 1D4VA 2X10A 3ME4A 3U3VA 3IJ2X 4J6GC 2H9GR 4E4DR 5L36B 1ZA3R 4MSVB 1NCFA 3QD6R 3THMF 3MHDD 3ALQR 1TNRR 2E4XA 2E4WA 4BK4A 2HEYR 3MBWA 4N90R 4FHQA 4GIQR 4BK5A 5IHLA 1D0GR 5CIRE 3BUKC 4M4PA 4M4RA 5DMJA 1DU3A 3FL7A 3U3PA 3X3FA 1SG1X 4YN0A 4KGQC 1EXTA 5BNQR 4KGGC 4RSUD 3WVTA 2HEVR 2AW2B 2UWIA
chains in the Genus database with same CATH topology
3URFZ 3QBQB 4MXWR 3ME2R 3K51B 4OD2S 3TJEF 1FT4A 3MI8D 4I9XC 3U3QA 3QO4A 1JMAB 3U3TA 3U3SA 1D4VA 2X10A 3ME4A 3U3VA 3IJ2X 4J6GC 2H9GR 4E4DR 5L36B 1ZA3R 4MSVB 1NCFA 3QD6R 3THMF 3MHDD 3ALQR 1TNRR 4BK4A 2HEYR 3MBWA 4N90R 4FHQA 4GIQR 4BK5A 5IHLA 1D0GR 5CIRE 3BUKC 4M4PA 4M4RA 5DMJA 1DU3A 3FL7A 3U3PA 3X3FA 1SG1X 4YN0A 4KGQC 1EXTA 5BNQR 4KGGC 4RSUD 3WVTA 2HEVR 2AW2B 2UWIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3URF Z;  3QBQ B;  4MXW R;  3ME2 R;  3K51 B;  4OD2 S;  3TJE F;  1FT4 A;  3MI8 D;  4I9X C;  3U3Q A;  3QO4 A;  1JMA B;  3U3T A;  3U3S A;  1D4V A;  2X10 A;  3ME4 A;  3U3V A;  3IJ2 X;  4J6G C;  2H9G R;  4E4D R;  5L36 B;  1ZA3 R;  4MSV B;  1NCF A;  3QD6 R;  3THM F;  3MHD D;  3ALQ R;  1TNR R;  4BK4 A;  2HEY R;  3MBW A;  4N90 R;  4FHQ A;  4GIQ R;  4BK5 A;  5IHL A;  1D0G R;  5CIR E;  3BUK C;  4M4P A;  4M4R A;  5DMJ A;  1DU3 A;  3FL7 A;  3U3P A;  3X3F A;  1SG1 X;  4YN0 A;  4KGQ C;  1EXT A;  5BNQ R;  4KGG C;  4RSU D;  3WVT A;  2HEV R;  2AW2 B;  2UWI A; 
#chains in the Genus database with same CATH topology
 3URF Z;  3QBQ B;  4MXW R;  3ME2 R;  2E4V A;  3K51 B;  4OD2 S;  1FT4 A;  3MI8 D;  4I9X C;  3TJE F;  2E4U A;  3U3Q A;  3QO4 A;  2E4Y A;  1JMA B;  2QR6 A;  3U3T A;  3U3S A;  1D4V A;  2X10 A;  3ME4 A;  3U3V A;  3IJ2 X;  4J6G C;  2H9G R;  4E4D R;  5L36 B;  1ZA3 R;  4MSV B;  1NCF A;  3QD6 R;  3THM F;  3MHD D;  3ALQ R;  1TNR R;  2E4X A;  2E4W A;  4BK4 A;  2HEY R;  3MBW A;  4N90 R;  4FHQ A;  4GIQ R;  4BK5 A;  5IHL A;  1D0G R;  5CIR E;  3BUK C;  4M4P A;  4M4R A;  5DMJ A;  1DU3 A;  3FL7 A;  3U3P A;  3X3F A;  1SG1 X;  4YN0 A;  4KGQ C;  1EXT A;  5BNQ R;  4KGG C;  4RSU D;  3WVT A;  2HEV R;  2AW2 B;  2UWI A; 
#chains in the Genus database with same CATH homology
 3URF Z;  3QBQ B;  4MXW R;  3ME2 R;  3K51 B;  4OD2 S;  3TJE F;  1FT4 A;  3MI8 D;  4I9X C;  3U3Q A;  3QO4 A;  1JMA B;  3U3T A;  3U3S A;  1D4V A;  2X10 A;  3ME4 A;  3U3V A;  3IJ2 X;  4J6G C;  2H9G R;  4E4D R;  5L36 B;  1ZA3 R;  4MSV B;  1NCF A;  3QD6 R;  3THM F;  3MHD D;  3ALQ R;  1TNR R;  4BK4 A;  2HEY R;  3MBW A;  4N90 R;  4FHQ A;  4GIQ R;  4BK5 A;  5IHL A;  1D0G R;  5CIR E;  3BUK C;  4M4P A;  4M4R A;  5DMJ A;  1DU3 A;  3FL7 A;  3U3P A;  3X3F A;  1SG1 X;  4YN0 A;  4KGQ C;  1EXT A;  5BNQ R;  4KGG C;  4RSU D;  3WVT A;  2HEV R;  2AW2 B;  2UWI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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