1FT4A

Photochemically-enhanced binding of small molecules to the tumor necrosis factor receptor-1
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
140
structure length
140
Chain Sequence
MDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENEC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR 1
publication title Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha.
pubmed doi rcsb
source organism Homo sapiens
total genus 20
structure length 140
sequence length 140
chains with identical sequence B
ec nomenclature
pdb deposition date 2000-09-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1ft4A02
2.10.50.10 Mainly Beta Ribbon Tumor Necrosis Factor Receptor, subunit A; domain 2 Tumor Necrosis Factor Receptor, subunit A, domain 2 1ft4A01
3THMF 1ZA3R 4RSUD 4FHQA 3URFZ 4BK5A 3U3SA 1DU3A 3ME4A 3U3PA 2H9GR 4N90R 5DMJA 3WVTA 4J6GC 5L36B 3K51B 3U3VA 4I9XC 1EXTA 4MSVB 1D0GR 3TJEF 3U3TA 5BNQR 1TNRR 3ALQR 1D4VA 2X10A 1SG1X 3IJ2X 3MHDD 3MI8D 4KGQC 3QO4A 1FT4A 2AW2B 1JMAB 3ME2R 1NCFA 3MBWA 4M4RA 2HEVR 3QBQB 4GIQR 4OD2S 4M4PA 3BUKC 3FL7A 3QD6R 4MXWR 2HEYR 2UWIA 4KGGC 5IHLA 4E4DR 3U3QA 4YN0A 5CIRE 3X3FA 4BK4A
chains in the Genus database with same CATH superfamily
3THMF 1ZA3R 4RSUD 4FHQA 3URFZ 4BK5A 3U3SA 1DU3A 2QR6A 3ME4A 3U3PA 2H9GR 4N90R 2E4WA 5DMJA 3WVTA 4J6GC 5L36B 3K51B 3U3VA 4I9XC 1EXTA 4MSVB 1D0GR 3TJEF 3U3TA 5BNQR 1TNRR 1D4VA 3ALQR 2X10A 1SG1X 3IJ2X 2E4XA 3MHDD 3MI8D 4KGQC 3QO4A 1FT4A 2AW2B 1JMAB 3ME2R 1NCFA 3MBWA 2E4VA 2HEVR 3QBQB 4GIQR 4M4RA 4M4PA 3BUKC 4OD2S 2E4YA 3FL7A 3QD6R 2E4UA 4MXWR 2HEYR 2UWIA 4KGGC 5IHLA 4E4DR 3U3QA 4YN0A 5CIRE 3X3FA 4BK4A
chains in the Genus database with same CATH topology
3THMF 1ZA3R 4RSUD 4FHQA 3URFZ 4BK5A 3U3SA 1DU3A 3ME4A 3U3PA 2H9GR 4N90R 5DMJA 3WVTA 4J6GC 5L36B 3K51B 3U3VA 4I9XC 1EXTA 4MSVB 1D0GR 3TJEF 3U3TA 5BNQR 1TNRR 3ALQR 1D4VA 2X10A 1SG1X 3IJ2X 3MHDD 3MI8D 4KGQC 3QO4A 1FT4A 2AW2B 1JMAB 3ME2R 1NCFA 3MBWA 4M4RA 2HEVR 3QBQB 4GIQR 4OD2S 4M4PA 3BUKC 3FL7A 3QD6R 4MXWR 2HEYR 2UWIA 4KGGC 5IHLA 4E4DR 3U3QA 4YN0A 5CIRE 3X3FA 4BK4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3THM F;  1ZA3 R;  4RSU D;  4FHQ A;  3URF Z;  4BK5 A;  3U3S A;  1DU3 A;  3ME4 A;  3U3P A;  2H9G R;  4N90 R;  5DMJ A;  3WVT A;  4J6G C;  5L36 B;  3K51 B;  3U3V A;  4I9X C;  1EXT A;  4MSV B;  1D0G R;  3TJE F;  3U3T A;  5BNQ R;  1TNR R;  3ALQ R;  1D4V A;  2X10 A;  1SG1 X;  3IJ2 X;  3MHD D;  3MI8 D;  4KGQ C;  3QO4 A;  1FT4 A;  2AW2 B;  1JMA B;  3ME2 R;  1NCF A;  3MBW A;  4M4R A;  2HEV R;  3QBQ B;  4GIQ R;  4OD2 S;  4M4P A;  3BUK C;  3FL7 A;  3QD6 R;  4MXW R;  2HEY R;  2UWI A;  4KGG C;  5IHL A;  4E4D R;  3U3Q A;  4YN0 A;  5CIR E;  3X3F A;  4BK4 A; 
#chains in the Genus database with same CATH topology
 3THM F;  1ZA3 R;  4RSU D;  4FHQ A;  3URF Z;  4BK5 A;  3U3S A;  1DU3 A;  2QR6 A;  3ME4 A;  3U3P A;  2H9G R;  4N90 R;  2E4W A;  5DMJ A;  3WVT A;  4J6G C;  5L36 B;  3K51 B;  3U3V A;  4I9X C;  1EXT A;  4MSV B;  1D0G R;  3TJE F;  3U3T A;  5BNQ R;  1TNR R;  1D4V A;  3ALQ R;  2X10 A;  1SG1 X;  3IJ2 X;  2E4X A;  3MHD D;  3MI8 D;  4KGQ C;  3QO4 A;  1FT4 A;  2AW2 B;  1JMA B;  3ME2 R;  1NCF A;  3MBW A;  2E4V A;  2HEV R;  3QBQ B;  4GIQ R;  4M4R A;  4M4P A;  3BUK C;  4OD2 S;  2E4Y A;  3FL7 A;  3QD6 R;  2E4U A;  4MXW R;  2HEY R;  2UWI A;  4KGG C;  5IHL A;  4E4D R;  3U3Q A;  4YN0 A;  5CIR E;  3X3F A;  4BK4 A; 
#chains in the Genus database with same CATH homology
 3THM F;  1ZA3 R;  4RSU D;  4FHQ A;  3URF Z;  4BK5 A;  3U3S A;  1DU3 A;  3ME4 A;  3U3P A;  2H9G R;  4N90 R;  5DMJ A;  3WVT A;  4J6G C;  5L36 B;  3K51 B;  3U3V A;  4I9X C;  1EXT A;  4MSV B;  1D0G R;  3TJE F;  3U3T A;  5BNQ R;  1TNR R;  3ALQ R;  1D4V A;  2X10 A;  1SG1 X;  3IJ2 X;  3MHD D;  3MI8 D;  4KGQ C;  3QO4 A;  1FT4 A;  2AW2 B;  1JMA B;  3ME2 R;  1NCF A;  3MBW A;  4M4R A;  2HEV R;  3QBQ B;  4GIQ R;  4OD2 S;  4M4P A;  3BUK C;  3FL7 A;  3QD6 R;  4MXW R;  2HEY R;  2UWI A;  4KGG C;  5IHL A;  4E4D R;  3U3Q A;  4YN0 A;  5CIR E;  3X3F A;  4BK4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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