1GC8A

The crystal structure of thermus thermophilus 3-isopropylmalate dehydrogenase mutated at 172th from ala to phe
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
345
structure length
345
Chain Sequence
MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEFARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Oxidoreductase
molecule keywords 3-ISOPROPYLMALATE DEHYDROGENASE
publication title Design, X-ray crystallography, molecular modelling and thermal stability studies of mutant enzymes at site 172 of 3-isopropylmalate dehydrogenase from Thermus thermophilus.
pubmed doi rcsb
source organism Thermus thermophilus
total genus 116
structure length 345
sequence length 345
chains with identical sequence B
ec nomenclature ec 1.1.1.85: 3-isopropylmalate dehydrogenase.
pdb deposition date 2000-07-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 1gc8A00
3WZWA 3UDOA 1PS6A 5GRFA 3VL7A 1ZORA 3TY4A 1GRPA 3LXYA 1PTMA 1V5BA 1V94A 2E5MA 3TNGA 2DHTA 1CM7A 2UXRA 3UDUA 4BNPA 9ICDA 1YXOA 3VKZA 3ASJA 1GC8A 3BLXB 2QFVA 1G2UA 2AYQA 1P8FA 5J33A 2HI1A 4L06A 3MASA 2QFXA 4AJBA 1X0LA 5GREB 2G4OA 2Y3ZA 2Y41A 3FLKA 5GRHA 1HJ6A 3AH3A 1R8KA 4KZOA 5HN3A 1U7NA 3TSNA 2UXQA 1DR0A 8ICDA 5GRIA 6ICDA 1IPDA 4ICDA 1DR8A 3VL2A 5LGEA 4XS3A 3MAPA 4AOVA 4YB4A 1CNZA 2D4VA 2Y42A 1IDFA 2D1CA 4AJCA 1IKAA 1A05A 1OSIA 3BLXA 4IWHA 5J34A 2Y40A 4AJRA 5J32A 2E0CA 1IDDA 1T0LA 3FMXX 1BL5A 1CW1A 1XACA 5GREA 4L03A 3TY3A 1GC9A 1AI2A 1V53A 4XXVA 5GRLB 3INMA 1LWDA 1DPZA 5HN5A 5HN4A 1OSJA 4AJAA 3U9EA 1PB1A 4WUOA 3WZYA 1IDMA 2IV0A 5I95A 1T09A 4AJ3A 4I3LA 4I3KA 4Y1PA 5DE1A 3US8A 4HCXA 2QFWA 4JA8A 1CW4A 5I96A 1PB3A 1XADA 3BLVB 1CW7A 1GROA 3MASB 2ZTWA 1VI1A 4AJSA 1XGVA 5ICDA 4UMYA 3R8WA 1WALA 1W0DA 5K10A 3UF6A 1IDCA 4JQPA 4XRXA 5GRLA 3VMLA 1XKDA 5GRFB 1XABA 1IDEA 1XAAA 5K11A 3MARA 3VMJA 3DMSA 5L57A 1ISOA 1AI3A 1VLCA 4UMXA 4AOYA 3LCBC 1HQSA 4L04A 5L58A 4P69C 1PS7A 3WZXA 1SJSA 3WZVA 7ICDA 3BLVA 1HEXA 3VL6A 3ICDA 3VL4A 3VL3A 4ATYA 4AOUA 1TYOA 5GRHB 3U1HA 5GRIB 1WPWA 3VMKA 2QFYA 1YCOA 4F7IA 5HN6A
chains in the Genus database with same CATH superfamily
3WZWA 3UDOA 1PS6A 5GRFA 3VL7A 1ZORA 3TY4A 1GRPA 3LXYA 1PTMA 1V5BA 1V94A 2E5MA 3TNGA 2DHTA 1CM7A 2UXRA 3UDUA 4BNPA 9ICDA 1YXOA 3VKZA 3ASJA 1GC8A 3BLXB 2QFVA 1G2UA 2AYQA 1P8FA 5J33A 2HI1A 4L06A 3MASA 2QFXA 4AJBA 1X0LA 5GREB 2G4OA 2Y3ZA 2Y41A 3FLKA 5GRHA 1HJ6A 3AH3A 1R8KA 4KZOA 5HN3A 1U7NA 3TSNA 2UXQA 1DR0A 8ICDA 5GRIA 6ICDA 1IPDA 4ICDA 1DR8A 3VL2A 5LGEA 4XS3A 3MAPA 4AOVA 4YB4A 1CNZA 2D4VA 2Y42A 1IDFA 2D1CA 4AJCA 1IKAA 1A05A 1OSIA 3BLXA 4IWHA 5J34A 2Y40A 4AJRA 5J32A 2E0CA 1IDDA 1T0LA 3FMXX 1BL5A 1CW1A 1XACA 5GREA 4L03A 3TY3A 1GC9A 1AI2A 1V53A 4XXVA 5GRLB 3INMA 1LWDA 1DPZA 5HN5A 5HN4A 1OSJA 4AJAA 3U9EA 1PB1A 4WUOA 3WZYA 1IDMA 2IV0A 5I95A 1T09A 4AJ3A 4I3LA 4I3KA 4Y1PA 5DE1A 3US8A 4HCXA 2QFWA 4JA8A 1CW4A 5I96A 1PB3A 1XADA 3BLVB 1CW7A 1GROA 3MASB 2ZTWA 1VI1A 4AJSA 1XGVA 5ICDA 4UMYA 3R8WA 1WALA 1W0DA 5K10A 3UF6A 1IDCA 4JQPA 4XRXA 5GRLA 3VMLA 1XKDA 5GRFB 1XABA 1IDEA 1XAAA 5K11A 3MARA 3VMJA 3DMSA 5L57A 1ISOA 1AI3A 1VLCA 4UMXA 4AOYA 3LCBC 1HQSA 4L04A 5L58A 4P69C 1PS7A 3WZXA 1SJSA 3WZVA 7ICDA 3BLVA 1HEXA 3VL6A 3ICDA 3VL4A 3VL3A 4ATYA 4AOUA 1TYOA 5GRHB 3U1HA 5GRIB 1WPWA 3VMKA 2QFYA 1YCOA 4F7IA 5HN6A
chains in the Genus database with same CATH topology
3WZWA 3UDOA 1PS6A 5GRFA 3VL7A 1ZORA 3TY4A 1GRPA 3LXYA 1PTMA 1V5BA 1V94A 2E5MA 3TNGA 2DHTA 1CM7A 2UXRA 3UDUA 4BNPA 9ICDA 1YXOA 3VKZA 3ASJA 1GC8A 3BLXB 2QFVA 1G2UA 2AYQA 1P8FA 5J33A 2HI1A 4L06A 3MASA 2QFXA 4AJBA 1X0LA 5GREB 2G4OA 2Y3ZA 2Y41A 3FLKA 5GRHA 1HJ6A 3AH3A 1R8KA 4KZOA 5HN3A 1U7NA 3TSNA 2UXQA 1DR0A 8ICDA 5GRIA 6ICDA 1IPDA 4ICDA 1DR8A 3VL2A 5LGEA 4XS3A 3MAPA 4AOVA 4YB4A 1CNZA 2D4VA 2Y42A 1IDFA 2D1CA 4AJCA 1IKAA 1A05A 1OSIA 3BLXA 4IWHA 5J34A 2Y40A 4AJRA 5J32A 2E0CA 1IDDA 1T0LA 3FMXX 1BL5A 1CW1A 1XACA 5GREA 4L03A 3TY3A 1GC9A 1AI2A 1V53A 4XXVA 5GRLB 3INMA 1LWDA 1DPZA 5HN5A 5HN4A 1OSJA 4AJAA 3U9EA 1PB1A 4WUOA 3WZYA 1IDMA 2IV0A 5I95A 1T09A 4AJ3A 4I3LA 4I3KA 4Y1PA 5DE1A 3US8A 4HCXA 2QFWA 4JA8A 1CW4A 5I96A 1PB3A 1XADA 3BLVB 1CW7A 1GROA 3MASB 2ZTWA 1VI1A 4AJSA 1XGVA 5ICDA 4UMYA 3R8WA 1WALA 1W0DA 5K10A 3UF6A 1IDCA 4JQPA 4XRXA 5GRLA 3VMLA 1XKDA 5GRFB 1XABA 1IDEA 1XAAA 5K11A 3MARA 3VMJA 3DMSA 5L57A 1ISOA 1AI3A 1VLCA 4UMXA 4AOYA 3LCBC 1HQSA 4L04A 5L58A 4P69C 1PS7A 3WZXA 1SJSA 3WZVA 7ICDA 3BLVA 1HEXA 3VL6A 3ICDA 3VL4A 3VL3A 4ATYA 4AOUA 1TYOA 5GRHB 3U1HA 5GRIB 1WPWA 3VMKA 2QFYA 1YCOA 4F7IA 5HN6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WZW A;  3UDO A;  1PS6 A;  5GRF A;  3VL7 A;  1ZOR A;  3TY4 A;  1GRP A;  3LXY A;  1PTM A;  1V5B A;  1V94 A;  2E5M A;  3TNG A;  2DHT A;  1CM7 A;  2UXR A;  3UDU A;  4BNP A;  9ICD A;  1YXO A;  3VKZ A;  3ASJ A;  1GC8 A;  3BLX B;  2QFV A;  1G2U A;  2AYQ A;  1P8F A;  5J33 A;  2HI1 A;  4L06 A;  3MAS A;  2QFX A;  4AJB A;  1X0L A;  5GRE B;  2G4O A;  2Y3Z A;  2Y41 A;  3FLK A;  5GRH A;  1HJ6 A;  3AH3 A;  1R8K A;  4KZO A;  5HN3 A;  1U7N A;  3TSN A;  2UXQ A;  1DR0 A;  8ICD A;  5GRI A;  6ICD A;  1IPD A;  4ICD A;  1DR8 A;  3VL2 A;  5LGE A;  4XS3 A;  3MAP A;  4AOV A;  4YB4 A;  1CNZ A;  2D4V A;  2Y42 A;  1IDF A;  2D1C A;  4AJC A;  1IKA A;  1A05 A;  1OSI A;  3BLX A;  4IWH A;  5J34 A;  2Y40 A;  4AJR A;  5J32 A;  2E0C A;  1IDD A;  1T0L A;  3FMX X;  1BL5 A;  1CW1 A;  1XAC A;  5GRE A;  4L03 A;  3TY3 A;  1GC9 A;  1AI2 A;  1V53 A;  4XXV A;  5GRL B;  3INM A;  1LWD A;  1DPZ A;  5HN5 A;  5HN4 A;  1OSJ A;  4AJA A;  3U9E A;  1PB1 A;  4WUO A;  3WZY A;  1IDM A;  2IV0 A;  5I95 A;  1T09 A;  4AJ3 A;  4I3L A;  4I3K A;  4Y1P A;  5DE1 A;  3US8 A;  4HCX A;  2QFW A;  4JA8 A;  1CW4 A;  5I96 A;  1PB3 A;  1XAD A;  3BLV B;  1CW7 A;  1GRO A;  3MAS B;  2ZTW A;  1VI1 A;  4AJS A;  1XGV A;  5ICD A;  4UMY A;  3R8W A;  1WAL A;  1W0D A;  5K10 A;  3UF6 A;  1IDC A;  4JQP A;  4XRX A;  5GRL A;  3VML A;  1XKD A;  5GRF B;  1XAB A;  1IDE A;  1XAA A;  5K11 A;  3MAR A;  3VMJ A;  3DMS A;  5L57 A;  1ISO A;  1AI3 A;  1VLC A;  4UMX A;  4AOY A;  3LCB C;  1HQS A;  4L04 A;  5L58 A;  4P69 C;  1PS7 A;  3WZX A;  1SJS A;  3WZV A;  7ICD A;  3BLV A;  1HEX A;  3VL6 A;  3ICD A;  3VL4 A;  3VL3 A;  4ATY A;  4AOU A;  1TYO A;  5GRH B;  3U1H A;  5GRI B;  1WPW A;  3VMK A;  2QFY A;  1YCO A;  4F7I A;  5HN6 A; 
#chains in the Genus database with same CATH topology
 3WZW A;  3UDO A;  1PS6 A;  5GRF A;  3VL7 A;  1ZOR A;  3TY4 A;  1GRP A;  3LXY A;  1PTM A;  1V5B A;  1V94 A;  2E5M A;  3TNG A;  2DHT A;  1CM7 A;  2UXR A;  3UDU A;  4BNP A;  9ICD A;  1YXO A;  3VKZ A;  3ASJ A;  1GC8 A;  3BLX B;  2QFV A;  1G2U A;  2AYQ A;  1P8F A;  5J33 A;  2HI1 A;  4L06 A;  3MAS A;  2QFX A;  4AJB A;  1X0L A;  5GRE B;  2G4O A;  2Y3Z A;  2Y41 A;  3FLK A;  5GRH A;  1HJ6 A;  3AH3 A;  1R8K A;  4KZO A;  5HN3 A;  1U7N A;  3TSN A;  2UXQ A;  1DR0 A;  8ICD A;  5GRI A;  6ICD A;  1IPD A;  4ICD A;  1DR8 A;  3VL2 A;  5LGE A;  4XS3 A;  3MAP A;  4AOV A;  4YB4 A;  1CNZ A;  2D4V A;  2Y42 A;  1IDF A;  2D1C A;  4AJC A;  1IKA A;  1A05 A;  1OSI A;  3BLX A;  4IWH A;  5J34 A;  2Y40 A;  4AJR A;  5J32 A;  2E0C A;  1IDD A;  1T0L A;  3FMX X;  1BL5 A;  1CW1 A;  1XAC A;  5GRE A;  4L03 A;  3TY3 A;  1GC9 A;  1AI2 A;  1V53 A;  4XXV A;  5GRL B;  3INM A;  1LWD A;  1DPZ A;  5HN5 A;  5HN4 A;  1OSJ A;  4AJA A;  3U9E A;  1PB1 A;  4WUO A;  3WZY A;  1IDM A;  2IV0 A;  5I95 A;  1T09 A;  4AJ3 A;  4I3L A;  4I3K A;  4Y1P A;  5DE1 A;  3US8 A;  4HCX A;  2QFW A;  4JA8 A;  1CW4 A;  5I96 A;  1PB3 A;  1XAD A;  3BLV B;  1CW7 A;  1GRO A;  3MAS B;  2ZTW A;  1VI1 A;  4AJS A;  1XGV A;  5ICD A;  4UMY A;  3R8W A;  1WAL A;  1W0D A;  5K10 A;  3UF6 A;  1IDC A;  4JQP A;  4XRX A;  5GRL A;  3VML A;  1XKD A;  5GRF B;  1XAB A;  1IDE A;  1XAA A;  5K11 A;  3MAR A;  3VMJ A;  3DMS A;  5L57 A;  1ISO A;  1AI3 A;  1VLC A;  4UMX A;  4AOY A;  3LCB C;  1HQS A;  4L04 A;  5L58 A;  4P69 C;  1PS7 A;  3WZX A;  1SJS A;  3WZV A;  7ICD A;  3BLV A;  1HEX A;  3VL6 A;  3ICD A;  3VL4 A;  3VL3 A;  4ATY A;  4AOU A;  1TYO A;  5GRH B;  3U1H A;  5GRI B;  1WPW A;  3VMK A;  2QFY A;  1YCO A;  4F7I A;  5HN6 A; 
#chains in the Genus database with same CATH homology
 3WZW A;  3UDO A;  1PS6 A;  5GRF A;  3VL7 A;  1ZOR A;  3TY4 A;  1GRP A;  3LXY A;  1PTM A;  1V5B A;  1V94 A;  2E5M A;  3TNG A;  2DHT A;  1CM7 A;  2UXR A;  3UDU A;  4BNP A;  9ICD A;  1YXO A;  3VKZ A;  3ASJ A;  1GC8 A;  3BLX B;  2QFV A;  1G2U A;  2AYQ A;  1P8F A;  5J33 A;  2HI1 A;  4L06 A;  3MAS A;  2QFX A;  4AJB A;  1X0L A;  5GRE B;  2G4O A;  2Y3Z A;  2Y41 A;  3FLK A;  5GRH A;  1HJ6 A;  3AH3 A;  1R8K A;  4KZO A;  5HN3 A;  1U7N A;  3TSN A;  2UXQ A;  1DR0 A;  8ICD A;  5GRI A;  6ICD A;  1IPD A;  4ICD A;  1DR8 A;  3VL2 A;  5LGE A;  4XS3 A;  3MAP A;  4AOV A;  4YB4 A;  1CNZ A;  2D4V A;  2Y42 A;  1IDF A;  2D1C A;  4AJC A;  1IKA A;  1A05 A;  1OSI A;  3BLX A;  4IWH A;  5J34 A;  2Y40 A;  4AJR A;  5J32 A;  2E0C A;  1IDD A;  1T0L A;  3FMX X;  1BL5 A;  1CW1 A;  1XAC A;  5GRE A;  4L03 A;  3TY3 A;  1GC9 A;  1AI2 A;  1V53 A;  4XXV A;  5GRL B;  3INM A;  1LWD A;  1DPZ A;  5HN5 A;  5HN4 A;  1OSJ A;  4AJA A;  3U9E A;  1PB1 A;  4WUO A;  3WZY A;  1IDM A;  2IV0 A;  5I95 A;  1T09 A;  4AJ3 A;  4I3L A;  4I3K A;  4Y1P A;  5DE1 A;  3US8 A;  4HCX A;  2QFW A;  4JA8 A;  1CW4 A;  5I96 A;  1PB3 A;  1XAD A;  3BLV B;  1CW7 A;  1GRO A;  3MAS B;  2ZTW A;  1VI1 A;  4AJS A;  1XGV A;  5ICD A;  4UMY A;  3R8W A;  1WAL A;  1W0D A;  5K10 A;  3UF6 A;  1IDC A;  4JQP A;  4XRX A;  5GRL A;  3VML A;  1XKD A;  5GRF B;  1XAB A;  1IDE A;  1XAA A;  5K11 A;  3MAR A;  3VMJ A;  3DMS A;  5L57 A;  1ISO A;  1AI3 A;  1VLC A;  4UMX A;  4AOY A;  3LCB C;  1HQS A;  4L04 A;  5L58 A;  4P69 C;  1PS7 A;  3WZX A;  1SJS A;  3WZV A;  7ICD A;  3BLV A;  1HEX A;  3VL6 A;  3ICD A;  3VL4 A;  3VL3 A;  4ATY A;  4AOU A;  1TYO A;  5GRH B;  3U1H A;  5GRI B;  1WPW A;  3VMK A;  2QFY A;  1YCO A;  4F7I A;  5HN6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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