1GO4A

Crystal structure of mad1-mad2 reveals a conserved mad2 binding motif in mad1 and cdc20.
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
196
structure length
196
Chain Sequence
EQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKDDSAPREKSQKAIQDEIRSVIAQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cell cycle
molecule keywords Mitotic spindle assembly checkpoint protein MAD2A
publication title Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint.
pubmed doi rcsb
source organism Homo sapiens
total genus 61
structure length 196
sequence length 196
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2001-10-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02301 HORMA HORMA domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.900.10 Alpha Beta 2-Layer Sandwich Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A HORMA domain 1go4A00
4TZMA 4TZOA 3ABEC 1DUJA 3GMHA 4TZQA 2QYFA 3ABDA 2V64D 1S2HA 4TRKA 5C50B 4GK5A 4YK8B 4TZJA 1KLQA 1GO4A 2VFXA 3VU7C 4FJOC 4J2GA 4TZLA 4AEZB 2V64A 4GK0A 4EXTC 4TZNA 4TZSA 5LCWZ
chains in the Genus database with same CATH superfamily
4TZMA 4TZOA 3ABEC 1DUJA 3GMHA 4TZQA 2QYFA 3ABDA 2V64D 1S2HA 4TRKA 5C50B 4GK5A 4YK8B 4TZJA 1KLQA 1GO4A 2VFXA 3VU7C 4FJOC 4J2GA 4TZLA 4AEZB 2V64A 2QYFB 4GK0A 4EXTC 4TZNA 4TZSA 5LCWZ
chains in the Genus database with same CATH topology
4TZMA 4TZOA 3ABEC 1DUJA 3GMHA 4TZQA 2QYFA 3ABDA 2V64D 1S2HA 4TRKA 5C50B 4GK5A 4YK8B 4TZJA 1KLQA 1GO4A 2VFXA 3VU7C 4FJOC 4J2GA 4TZLA 4AEZB 2V64A 4GK0A 4EXTC 4TZNA 4TZSA 5LCWZ
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TZM A;  4TZO A;  3ABE C;  1DUJ A;  3GMH A;  4TZQ A;  2QYF A;  3ABD A;  2V64 D;  1S2H A;  4TRK A;  5C50 B;  4GK5 A;  4YK8 B;  4TZJ A;  1KLQ A;  1GO4 A;  2VFX A;  3VU7 C;  4FJO C;  4J2G A;  4TZL A;  4AEZ B;  2V64 A;  4GK0 A;  4EXT C;  4TZN A;  4TZS A;  5LCW Z; 
#chains in the Genus database with same CATH topology
 4TZM A;  4TZO A;  3ABE C;  1DUJ A;  3GMH A;  4TZQ A;  2QYF A;  3ABD A;  2V64 D;  1S2H A;  4TRK A;  5C50 B;  4GK5 A;  4YK8 B;  4TZJ A;  1KLQ A;  1GO4 A;  2VFX A;  3VU7 C;  4FJO C;  4J2G A;  4TZL A;  4AEZ B;  2V64 A;  2QYF B;  4GK0 A;  4EXT C;  4TZN A;  4TZS A;  5LCW Z; 
#chains in the Genus database with same CATH homology
 4TZM A;  4TZO A;  3ABE C;  1DUJ A;  3GMH A;  4TZQ A;  2QYF A;  3ABD A;  2V64 D;  1S2H A;  4TRK A;  5C50 B;  4GK5 A;  4YK8 B;  4TZJ A;  1KLQ A;  1GO4 A;  2VFX A;  3VU7 C;  4FJO C;  4J2G A;  4TZL A;  4AEZ B;  2V64 A;  4GK0 A;  4EXT C;  4TZN A;  4TZS A;  5LCW Z; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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