1GZYB

Human insulin-like growth factor; in-house data
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
64
structure length
57
Chain Sequence
ETLCGAELVDALQFVCGDRGFYFNKPTGYPQTGIVDECCFRSCDLRRLEMYCAPLKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Growth factor
molecule keywords INSULIN-LIKE GROWTH FACTOR I
publication title Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
pubmed doi rcsb
source organism Homo sapiens
total genus 15
structure length 57
sequence length 64
ec nomenclature
pdb deposition date 2002-06-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 1gzyB00
1EFEA 1GZYB 2KJIA 2DSPI 1WQJI 1GZRB 5L3MA 1H59A 1IGLA 2DSRI 3GF1A 3KR3D 1SJUA 2JZQA 1TGRA 2DSQC 4XSSB 1IMXA 2KQPA 5L3NA 1B9GA 2LWZA 2GF1A 1GZZB 1H02B 3LRIA 1ZEIA 1PMXA 2L29B 6INSE 5L3LA 1BQTA
chains in the Genus database with same CATH superfamily
1EFEA 1GZYB 2KJIA 2DSPI 1WQJI 1GZRB 5L3MA 1H59A 1IGLA 2DSRI 3GF1A 3KR3D 1SJUA 2JZQA 1TGRA 2DSQC 4XSSB 2L14B 1IMXA 2KQPA 5L3NA 1B9GA 2LWZA 2GF1A 1GZZB 1H02B 3F2BA 3LRIA 1ZEIA 1PMXA 3F2CA 2L29B 6INSE 5L3LA 1BQTA 3F2DA
chains in the Genus database with same CATH topology
1EFEA 1GZYB 2KJIA 2DSPI 1WQJI 1GZRB 5L3MA 1H59A 1IGLA 2DSRI 3GF1A 3KR3D 1SJUA 2JZQA 1TGRA 2DSQC 4XSSB 1IMXA 2KQPA 5L3NA 1B9GA 2LWZA 2GF1A 1GZZB 1H02B 3LRIA 1ZEIA 1PMXA 2L29B 6INSE 5L3LA 1BQTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EFE A;  1GZY B;  2KJI A;  2DSP I;  1WQJ I;  1GZR B;  5L3M A;  1H59 A;  1IGL A;  2DSR I;  3GF1 A;  3KR3 D;  1SJU A;  2JZQ A;  1TGR A;  2DSQ C;  4XSS B;  1IMX A;  2KQP A;  5L3N A;  1B9G A;  2LWZ A;  2GF1 A;  1GZZ B;  1H02 B;  3LRI A;  1ZEI A;  1PMX A;  2L29 B;  6INS E;  5L3L A;  1BQT A; 
#chains in the Genus database with same CATH topology
 1EFE A;  1GZY B;  2KJI A;  2DSP I;  1WQJ I;  1GZR B;  5L3M A;  1H59 A;  1IGL A;  2DSR I;  3GF1 A;  3KR3 D;  1SJU A;  2JZQ A;  1TGR A;  2DSQ C;  4XSS B;  2L14 B;  1IMX A;  2KQP A;  5L3N A;  1B9G A;  2LWZ A;  2GF1 A;  1GZZ B;  1H02 B;  3F2B A;  3LRI A;  1ZEI A;  1PMX A;  3F2C A;  2L29 B;  6INS E;  5L3L A;  1BQT A;  3F2D A; 
#chains in the Genus database with same CATH homology
 1EFE A;  1GZY B;  2KJI A;  2DSP I;  1WQJ I;  1GZR B;  5L3M A;  1H59 A;  1IGL A;  2DSR I;  3GF1 A;  3KR3 D;  1SJU A;  2JZQ A;  1TGR A;  2DSQ C;  4XSS B;  1IMX A;  2KQP A;  5L3N A;  1B9G A;  2LWZ A;  2GF1 A;  1GZZ B;  1H02 B;  3LRI A;  1ZEI A;  1PMX A;  2L29 B;  6INS E;  5L3L A;  1BQT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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