1HEXA

Structure of 3-isopropylmalate dehydrogenase in complex with nad+: ligand-induced loop-closing and mechanism for cofactor specificity
Total Genus 114
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
114
sequence length
345
structure length
345
Chain Sequence
MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords 3-ISOPROPYLMALATE DEHYDROGENASE
publication title Structure of 3-isopropylmalate dehydrogenase in complex with NAD+: ligand-induced loop closing and mechanism for cofactor specificity.
pubmed doi rcsb
source organism Thermus thermophilus
total genus 114
structure length 345
sequence length 345
ec nomenclature ec 1.1.1.85: 3-isopropylmalate dehydrogenase.
pdb deposition date 1994-09-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 1hexA00
5HN3A 1IDEA 1AI3A 2UXQA 1GC8A 7ICDA 5L58A 2AYQA 1LWDA 4L03A 5GRHB 3VMKA 1SJSA 3FLKA 5HN4A 4AJ3A 2HI1A 1XGVA 3VL6A 1HEXA 4AJSA 1IPDA 1ISOA 3VL4A 1YCOA 3INMA 5J34A 1T0LA 4KZOA 3VMLA 3MARA 3TY3A 5J33A 2Y3ZA 1HQSA 3BLXA 5GREA 1CW1A 3U9EA 3UDUA 1CW7A 1GC9A 1XABA 3AH3A 2QFXA 5DE1A 5GRLA 5HN5A 2E0CA 1W0DA 5J32A 1CM7A 1OSIA 4AOUA 3BLVB 2D4VA 5GRFB 2QFYA 1IDCA 4AJCA 1HJ6A 3MASB 2G4OA 2E5MA 3U1HA 4UMYA 2DHTA 4P69C 1ZORA 6ICDA 2IV0A 1VLCA 3ASJA 5GRHA 4ATYA 5GRFA 1IDDA 3LXYA 4Y1PA 4AOYA 1BL5A 1V94A 1PS6A 1A05A 1PTMA 5GRIB 3TNGA 4AJAA 4I3LA 3TSNA 1GROA 1WPWA 4JA8A 4L04A 3MAPA 3VL2A 1V5BA 1DR0A 1TYOA 4XRXA 3WZYA 1YXOA 3VKZA 1X0LA 5L57A 2UXRA 3VL3A 4IWHA 1P8FA 1IDFA 1PS7A 3VL7A 4AJBA 5ICDA 5LGEA 3UDOA 3BLVA 5K10A 3WZWA 2QFWA 3VMJA 4UMXA 5HN6A 1CW4A 3MASA 3DMSA 1AI2A 1OSJA 4XXVA 1PB3A 5K11A 4XS3A 1CNZA 4AJRA 3ICDA 1IDMA 1GRPA 2QFVA 4HCXA 2D1CA 9ICDA 1XAAA 1PB1A 3R8WA 3FMXX 4YB4A 4L06A 4ICDA 4BNPA 2ZTWA 1V53A 4F7IA 1XACA 2Y40A 1R8KA 1WALA 3BLXB 1T09A 4JQPA 2Y41A 4I3KA 5GREB 3UF6A 1DR8A 3WZXA 5GRIA 8ICDA 5I95A 5I96A 3US8A 4AOVA 1IKAA 1XADA 3TY4A 5GRLB 4WUOA 1DPZA 1XKDA 2Y42A 1U7NA 1G2UA 3LCBC 1VI1A 3WZVA
chains in the Genus database with same CATH superfamily
5HN3A 1IDEA 1AI3A 2UXQA 1GC8A 7ICDA 5L58A 2AYQA 1LWDA 4L03A 5GRHB 3VMKA 1SJSA 3FLKA 5HN4A 4AJ3A 2HI1A 1XGVA 3VL6A 1HEXA 4AJSA 1IPDA 1ISOA 3VL4A 1YCOA 3INMA 5J34A 1T0LA 4KZOA 3VMLA 3MARA 3TY3A 5J33A 2Y3ZA 1HQSA 3BLXA 5GREA 1CW1A 3U9EA 3UDUA 1CW7A 1GC9A 1XABA 3AH3A 2QFXA 5DE1A 5GRLA 5HN5A 2E0CA 1W0DA 5J32A 1CM7A 1OSIA 4AOUA 3BLVB 2D4VA 5GRFB 2QFYA 1IDCA 4AJCA 1HJ6A 3MASB 2G4OA 2E5MA 3U1HA 4UMYA 2DHTA 4P69C 1ZORA 6ICDA 2IV0A 1VLCA 3ASJA 5GRHA 4ATYA 5GRFA 1IDDA 3LXYA 4Y1PA 4AOYA 1BL5A 1V94A 1PS6A 1A05A 1PTMA 5GRIB 3TNGA 4AJAA 4I3LA 3TSNA 1GROA 1WPWA 4JA8A 4L04A 3MAPA 3VL2A 1V5BA 1DR0A 1TYOA 4XRXA 3WZYA 1YXOA 3VKZA 1X0LA 5L57A 2UXRA 3VL3A 4IWHA 1P8FA 1IDFA 1PS7A 3VL7A 4AJBA 5ICDA 5LGEA 3UDOA 3BLVA 5K10A 3WZWA 2QFWA 3VMJA 4UMXA 5HN6A 1CW4A 3MASA 3DMSA 1AI2A 1OSJA 4XXVA 1PB3A 5K11A 4XS3A 1CNZA 4AJRA 3ICDA 1IDMA 1GRPA 2QFVA 4HCXA 2D1CA 9ICDA 1XAAA 1PB1A 3R8WA 3FMXX 4YB4A 4L06A 4ICDA 4BNPA 2ZTWA 1V53A 4F7IA 1XACA 2Y40A 1R8KA 1WALA 3BLXB 1T09A 4JQPA 2Y41A 4I3KA 5GREB 3UF6A 1DR8A 3WZXA 5GRIA 8ICDA 5I95A 5I96A 3US8A 4AOVA 1IKAA 1XADA 3TY4A 5GRLB 4WUOA 1DPZA 1XKDA 2Y42A 1U7NA 1G2UA 3LCBC 1VI1A 3WZVA
chains in the Genus database with same CATH topology
5HN3A 1IDEA 1AI3A 2UXQA 1GC8A 7ICDA 5L58A 2AYQA 1LWDA 4L03A 5GRHB 3VMKA 1SJSA 3FLKA 5HN4A 4AJ3A 2HI1A 1XGVA 3VL6A 1HEXA 4AJSA 1IPDA 1ISOA 3VL4A 1YCOA 3INMA 5J34A 1T0LA 4KZOA 3VMLA 3MARA 3TY3A 5J33A 2Y3ZA 1HQSA 3BLXA 5GREA 1CW1A 3U9EA 3UDUA 1CW7A 1GC9A 1XABA 3AH3A 2QFXA 5DE1A 5GRLA 5HN5A 2E0CA 1W0DA 5J32A 1CM7A 1OSIA 4AOUA 3BLVB 2D4VA 5GRFB 2QFYA 1IDCA 4AJCA 1HJ6A 3MASB 2G4OA 2E5MA 3U1HA 4UMYA 2DHTA 4P69C 1ZORA 6ICDA 2IV0A 1VLCA 3ASJA 5GRHA 4ATYA 5GRFA 1IDDA 3LXYA 4Y1PA 4AOYA 1BL5A 1V94A 1PS6A 1A05A 1PTMA 5GRIB 3TNGA 4AJAA 4I3LA 3TSNA 1GROA 1WPWA 4JA8A 4L04A 3MAPA 3VL2A 1V5BA 1DR0A 1TYOA 4XRXA 3WZYA 1YXOA 3VKZA 1X0LA 5L57A 2UXRA 3VL3A 4IWHA 1P8FA 1IDFA 1PS7A 3VL7A 4AJBA 5ICDA 5LGEA 3UDOA 3BLVA 5K10A 3WZWA 2QFWA 3VMJA 4UMXA 5HN6A 1CW4A 3MASA 3DMSA 1AI2A 1OSJA 4XXVA 1PB3A 5K11A 4XS3A 1CNZA 4AJRA 3ICDA 1IDMA 1GRPA 2QFVA 4HCXA 2D1CA 9ICDA 1XAAA 1PB1A 3R8WA 3FMXX 4YB4A 4L06A 4ICDA 4BNPA 2ZTWA 1V53A 4F7IA 1XACA 2Y40A 1R8KA 1WALA 3BLXB 1T09A 4JQPA 2Y41A 4I3KA 5GREB 3UF6A 1DR8A 3WZXA 5GRIA 8ICDA 5I95A 5I96A 3US8A 4AOVA 1IKAA 1XADA 3TY4A 5GRLB 4WUOA 1DPZA 1XKDA 2Y42A 1U7NA 1G2UA 3LCBC 1VI1A 3WZVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HN3 A;  1IDE A;  1AI3 A;  2UXQ A;  1GC8 A;  7ICD A;  5L58 A;  2AYQ A;  1LWD A;  4L03 A;  5GRH B;  3VMK A;  1SJS A;  3FLK A;  5HN4 A;  4AJ3 A;  2HI1 A;  1XGV A;  3VL6 A;  1HEX A;  4AJS A;  1IPD A;  1ISO A;  3VL4 A;  1YCO A;  3INM A;  5J34 A;  1T0L A;  4KZO A;  3VML A;  3MAR A;  3TY3 A;  5J33 A;  2Y3Z A;  1HQS A;  3BLX A;  5GRE A;  1CW1 A;  3U9E A;  3UDU A;  1CW7 A;  1GC9 A;  1XAB A;  3AH3 A;  2QFX A;  5DE1 A;  5GRL A;  5HN5 A;  2E0C A;  1W0D A;  5J32 A;  1CM7 A;  1OSI A;  4AOU A;  3BLV B;  2D4V A;  5GRF B;  2QFY A;  1IDC A;  4AJC A;  1HJ6 A;  3MAS B;  2G4O A;  2E5M A;  3U1H A;  4UMY A;  2DHT A;  4P69 C;  1ZOR A;  6ICD A;  2IV0 A;  1VLC A;  3ASJ A;  5GRH A;  4ATY A;  5GRF A;  1IDD A;  3LXY A;  4Y1P A;  4AOY A;  1BL5 A;  1V94 A;  1PS6 A;  1A05 A;  1PTM A;  5GRI B;  3TNG A;  4AJA A;  4I3L A;  3TSN A;  1GRO A;  1WPW A;  4JA8 A;  4L04 A;  3MAP A;  3VL2 A;  1V5B A;  1DR0 A;  1TYO A;  4XRX A;  3WZY A;  1YXO A;  3VKZ A;  1X0L A;  5L57 A;  2UXR A;  3VL3 A;  4IWH A;  1P8F A;  1IDF A;  1PS7 A;  3VL7 A;  4AJB A;  5ICD A;  5LGE A;  3UDO A;  3BLV A;  5K10 A;  3WZW A;  2QFW A;  3VMJ A;  4UMX A;  5HN6 A;  1CW4 A;  3MAS A;  3DMS A;  1AI2 A;  1OSJ A;  4XXV A;  1PB3 A;  5K11 A;  4XS3 A;  1CNZ A;  4AJR A;  3ICD A;  1IDM A;  1GRP A;  2QFV A;  4HCX A;  2D1C A;  9ICD A;  1XAA A;  1PB1 A;  3R8W A;  3FMX X;  4YB4 A;  4L06 A;  4ICD A;  4BNP A;  2ZTW A;  1V53 A;  4F7I A;  1XAC A;  2Y40 A;  1R8K A;  1WAL A;  3BLX B;  1T09 A;  4JQP A;  2Y41 A;  4I3K A;  5GRE B;  3UF6 A;  1DR8 A;  3WZX A;  5GRI A;  8ICD A;  5I95 A;  5I96 A;  3US8 A;  4AOV A;  1IKA A;  1XAD A;  3TY4 A;  5GRL B;  4WUO A;  1DPZ A;  1XKD A;  2Y42 A;  1U7N A;  1G2U A;  3LCB C;  1VI1 A;  3WZV A; 
#chains in the Genus database with same CATH topology
 5HN3 A;  1IDE A;  1AI3 A;  2UXQ A;  1GC8 A;  7ICD A;  5L58 A;  2AYQ A;  1LWD A;  4L03 A;  5GRH B;  3VMK A;  1SJS A;  3FLK A;  5HN4 A;  4AJ3 A;  2HI1 A;  1XGV A;  3VL6 A;  1HEX A;  4AJS A;  1IPD A;  1ISO A;  3VL4 A;  1YCO A;  3INM A;  5J34 A;  1T0L A;  4KZO A;  3VML A;  3MAR A;  3TY3 A;  5J33 A;  2Y3Z A;  1HQS A;  3BLX A;  5GRE A;  1CW1 A;  3U9E A;  3UDU A;  1CW7 A;  1GC9 A;  1XAB A;  3AH3 A;  2QFX A;  5DE1 A;  5GRL A;  5HN5 A;  2E0C A;  1W0D A;  5J32 A;  1CM7 A;  1OSI A;  4AOU A;  3BLV B;  2D4V A;  5GRF B;  2QFY A;  1IDC A;  4AJC A;  1HJ6 A;  3MAS B;  2G4O A;  2E5M A;  3U1H A;  4UMY A;  2DHT A;  4P69 C;  1ZOR A;  6ICD A;  2IV0 A;  1VLC A;  3ASJ A;  5GRH A;  4ATY A;  5GRF A;  1IDD A;  3LXY A;  4Y1P A;  4AOY A;  1BL5 A;  1V94 A;  1PS6 A;  1A05 A;  1PTM A;  5GRI B;  3TNG A;  4AJA A;  4I3L A;  3TSN A;  1GRO A;  1WPW A;  4JA8 A;  4L04 A;  3MAP A;  3VL2 A;  1V5B A;  1DR0 A;  1TYO A;  4XRX A;  3WZY A;  1YXO A;  3VKZ A;  1X0L A;  5L57 A;  2UXR A;  3VL3 A;  4IWH A;  1P8F A;  1IDF A;  1PS7 A;  3VL7 A;  4AJB A;  5ICD A;  5LGE A;  3UDO A;  3BLV A;  5K10 A;  3WZW A;  2QFW A;  3VMJ A;  4UMX A;  5HN6 A;  1CW4 A;  3MAS A;  3DMS A;  1AI2 A;  1OSJ A;  4XXV A;  1PB3 A;  5K11 A;  4XS3 A;  1CNZ A;  4AJR A;  3ICD A;  1IDM A;  1GRP A;  2QFV A;  4HCX A;  2D1C A;  9ICD A;  1XAA A;  1PB1 A;  3R8W A;  3FMX X;  4YB4 A;  4L06 A;  4ICD A;  4BNP A;  2ZTW A;  1V53 A;  4F7I A;  1XAC A;  2Y40 A;  1R8K A;  1WAL A;  3BLX B;  1T09 A;  4JQP A;  2Y41 A;  4I3K A;  5GRE B;  3UF6 A;  1DR8 A;  3WZX A;  5GRI A;  8ICD A;  5I95 A;  5I96 A;  3US8 A;  4AOV A;  1IKA A;  1XAD A;  3TY4 A;  5GRL B;  4WUO A;  1DPZ A;  1XKD A;  2Y42 A;  1U7N A;  1G2U A;  3LCB C;  1VI1 A;  3WZV A; 
#chains in the Genus database with same CATH homology
 5HN3 A;  1IDE A;  1AI3 A;  2UXQ A;  1GC8 A;  7ICD A;  5L58 A;  2AYQ A;  1LWD A;  4L03 A;  5GRH B;  3VMK A;  1SJS A;  3FLK A;  5HN4 A;  4AJ3 A;  2HI1 A;  1XGV A;  3VL6 A;  1HEX A;  4AJS A;  1IPD A;  1ISO A;  3VL4 A;  1YCO A;  3INM A;  5J34 A;  1T0L A;  4KZO A;  3VML A;  3MAR A;  3TY3 A;  5J33 A;  2Y3Z A;  1HQS A;  3BLX A;  5GRE A;  1CW1 A;  3U9E A;  3UDU A;  1CW7 A;  1GC9 A;  1XAB A;  3AH3 A;  2QFX A;  5DE1 A;  5GRL A;  5HN5 A;  2E0C A;  1W0D A;  5J32 A;  1CM7 A;  1OSI A;  4AOU A;  3BLV B;  2D4V A;  5GRF B;  2QFY A;  1IDC A;  4AJC A;  1HJ6 A;  3MAS B;  2G4O A;  2E5M A;  3U1H A;  4UMY A;  2DHT A;  4P69 C;  1ZOR A;  6ICD A;  2IV0 A;  1VLC A;  3ASJ A;  5GRH A;  4ATY A;  5GRF A;  1IDD A;  3LXY A;  4Y1P A;  4AOY A;  1BL5 A;  1V94 A;  1PS6 A;  1A05 A;  1PTM A;  5GRI B;  3TNG A;  4AJA A;  4I3L A;  3TSN A;  1GRO A;  1WPW A;  4JA8 A;  4L04 A;  3MAP A;  3VL2 A;  1V5B A;  1DR0 A;  1TYO A;  4XRX A;  3WZY A;  1YXO A;  3VKZ A;  1X0L A;  5L57 A;  2UXR A;  3VL3 A;  4IWH A;  1P8F A;  1IDF A;  1PS7 A;  3VL7 A;  4AJB A;  5ICD A;  5LGE A;  3UDO A;  3BLV A;  5K10 A;  3WZW A;  2QFW A;  3VMJ A;  4UMX A;  5HN6 A;  1CW4 A;  3MAS A;  3DMS A;  1AI2 A;  1OSJ A;  4XXV A;  1PB3 A;  5K11 A;  4XS3 A;  1CNZ A;  4AJR A;  3ICD A;  1IDM A;  1GRP A;  2QFV A;  4HCX A;  2D1C A;  9ICD A;  1XAA A;  1PB1 A;  3R8W A;  3FMX X;  4YB4 A;  4L06 A;  4ICD A;  4BNP A;  2ZTW A;  1V53 A;  4F7I A;  1XAC A;  2Y40 A;  1R8K A;  1WAL A;  3BLX B;  1T09 A;  4JQP A;  2Y41 A;  4I3K A;  5GRE B;  3UF6 A;  1DR8 A;  3WZX A;  5GRI A;  8ICD A;  5I95 A;  5I96 A;  3US8 A;  4AOV A;  1IKA A;  1XAD A;  3TY4 A;  5GRL B;  4WUO A;  1DPZ A;  1XKD A;  2Y42 A;  1U7N A;  1G2U A;  3LCB C;  1VI1 A;  3WZV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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