1HK1A

Human serum albumin complexed with thyroxine (3,3',5,5'-tetraiodo-l-thyronine)
Total Genus 210
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
210
sequence length
565
structure length
553
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTDCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords SERUM ALBUMIN
publication title Structural Basis of Albumin-Thyroxine Interactions and Familial Dysalbuminemic Hyperthyroxinemia
pubmed doi rcsb
source organism Homo sapiens
molecule tags Plasma protein
total genus 210
structure length 553
sequence length 565
ec nomenclature
pdb deposition date 2003-03-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk1A03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk1A02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk1A04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk1A01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk1A06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk1A05
4LUHA 3B9MA 1KXPD 5DQFA 1J7EA 2BXGA 1GNIA 2BXMA 5IFOA 1AO6A 4F5UA 2I2ZA 2BXEA 1HK5A 4E99A 3A73A 4K2CA 4HGMB 4HGKA 5IJEA 4S1YA 2BXPA 4F5SA 3LU7A 3LU8A 1J78A 3JRYA 3LU6A 3V03A 4LB9A 1E7GA 1UORA 5IIHA 1E7AA 4ZBRA 2BXKA 4L9QA 2BXLA 1H9ZA 4F5TA 1E7EA 2BXIA 1E78A 1N5UA 1MA9A 2XVQA 2VDBA 1BJ5A 4Z69A 1HK4A 4JK4A 3B9LA 4L9KA 1LOTA 4LUFA 2BX8A 2XVVA 2XW0A 4LA0A 5FUOA 2YDFA 1E7BA 4EMXA 4F5VA 4PO0A 2BXAA 2XSIA 2XVWA 5HOZA 1O9XA 5ID7A 5ID9A 2BXOA 5IJ5A 3TDLA 3SQJA 2VUFA 3JQZA 1HA2A 5DBYA 3UIVA 1E7IA 1HK1A 4ZBQA 1HK3A 3V09A 1HK2A 4LB2A 2BXDA 4OT2A 2I30A 2BXFA 2VUEA 1E7FA 1GNJA 4BKEA 5IIUA 4IW2A 2BXQA 5IJFA 1BKEA 2BXNA 5GHKA 4G03A 1BM0A 1E7CA 4G04A 2BXBA 4N0FD 1TF0A 4J2VA 4IW1A 1E7HA 3V08A 4OR0A 4L8UA 2XW1A 2BXHA 1KW2A 2BXCA 4K71A 2XVUA 5IIXA 4N0UD 3CX9A
chains in the Genus database with same CATH superfamily
1MIYA 4LUHA 3B9MA 3SIUB 1KXPD 5DQFA 1J7EA 2DBWA 5D7GA 4TQ1A 4TQ0A 2QHBA 2BXGA 3GA9L 4W4UB 1GNIA 4DM0A 2BXMA 4FK5B 5IFOA 3H37A 1AO6A 4F5UA 2LQHA 3NMUA 2I2ZA 2DYOA 3ICXA 3PLAA 2BXEA 3H3AA 2JUHA 2Z8JA 1HK5A 2DG5A 4E99A 4G01A 2XMOA 3A73A 4K2CA 2OT3A 4HGMB 4HGKA 1VFIA 3W1SA 5IJEA 2LXSA 4S1YA 2BXPA 4F5SA 2LQIA 4FIPB 3LU7A 1SB0A 2DYMA 3LU8A 4BY9C 2OZBB 1MIWA 1J78A 3JRYA 3LU6A 3V03A 1JNBA 3NVKA 4OTTA 4LB9A 1E7GA 1UORA 4C31B 5IIHA 2EFDA 4FJCB 1E7AA 4ZBRA 2BXKA 4L9QA 1KDXA 2Z8IA 2E0XA 2BXLA 3NVIA 1H9ZA 4F5TA 1E7EA 4ZBKA 1VZSA 3FNMA 2ROHA 2BXIA 4ZCGA 1E78A 1N5UA 3NVMA 3VQIA 1MA9A 2XVQA 4N3ZA 2VDBA 1BJ5A 4Z69A 1HK4A 1TXUA 4ZUXV 4JK4A 3B9LA 4L9KA 1LOTA 4LUFA 2BX8A 2XVVA 2XW0A 4LA0A 5FUOA 2YDFA 1E7BA 5GINA 4EMXA 4F5VA 4PO0A 2BXAA 5B5TA 3SIVB 2XSIA 2XVWA 5HOZA 1O9XA 5ID7A 2Z8KA 5ID9A 2BXOA 2E0YA 5IJ5A 3TDLA 1LNSA 3WHSA 2EFCA 3FWCC 3MHSB 3SQJA 2VUFA 3M99C 5GIPA 3MHHB 3JQZA 2DBUA 2KBZA 1HA2A 5DBYA 1MUHA 3UIVA 2EFEA 2AGHB 1E7IA 3G9KD 2EFHA 1HK1A 4ZBQA 4DHXB 1HK3A 4M70B 3V09A 1HK2A 3WHQA 4LB2A 2BXDA 2K0NA 4GG2A 2QMCA 2DBXA 4GDLB 4OT2A 2I30A 3FWBC 2BXFA 1IJGA 2VUEA 4Z9OA 1E7FA 1GNJA 4BKEA 5IIUA 4IW2A 4WA6B 2QM6A 2CKXA 1MM8A 1MIVA 2BXQA 1MUSA 1H5WA 2KWFA 5IJFA 2NQOA 5BPKA 4I9OA 3WHRA 1BKEA 2BXNA 5GHKA 4G03A 2LOQA 5GIOA 4NAWB 1BM0A 1E7CA 1FOUA 3GQXA 4GDKB 2LXTA 4MBEC 4G04A 2BXBA 2GUTA 1TF0A 3KJLA 4N0FD 4ZC6A 3ECPA 4J2VA 4GDXA 4IW1A 2NNWA 1E7HA 3BPJA 3V08A 4OR0A 4OTUA 3GQUA 4L8UA 2XW1A 2BXHA 3KIKA 2V36A 1KW2A 3A75A 2BXCA 4K71A 2XVUA 5IIXA 4D7XA 1NT2B 4N0UD 3CX9A 2AJEA
chains in the Genus database with same CATH topology
1MIYA 4LUHA 3B9MA 3SIUB 1KXPD 5DQFA 1J7EA 2DBWA 5D7GA 4TQ1A 4TQ0A 2QHBA 2BXGA 3GA9L 4W4UB 1GNIA 2BXMA 4FK5B 5IFOA 3H37A 1AO6A 4F5UA 3NMUA 2I2ZA 2DYOA 3ICXA 3PLAA 2BXEA 3H3AA 2JUHA 2Z8JA 1HK5A 2DG5A 4E99A 4G01A 2XMOA 3A73A 4K2CA 2OT3A 4HGMB 4HGKA 1VFIA 3W1SA 5IJEA 4S1YA 2BXPA 4F5SA 4FIPB 3LU7A 2DYMA 3LU8A 4BY9C 2OZBB 1MIWA 1J78A 3JRYA 3LU6A 3V03A 1JNBA 3NVKA 4OTTA 4LB9A 1E7GA 1UORA 4C31B 5IIHA 2EFDA 4FJCB 1E7AA 4ZBRA 2BXKA 4L9QA 2Z8IA 2E0XA 2BXLA 3NVIA 1H9ZA 4F5TA 1E7EA 4ZBKA 1VZSA 3FNMA 2ROHA 2BXIA 4ZCGA 1E78A 1N5UA 3NVMA 3VQIA 1MA9A 2XVQA 4N3ZA 2VDBA 1BJ5A 4Z69A 1HK4A 1TXUA 4ZUXV 4JK4A 3B9LA 4L9KA 1LOTA 4LUFA 2BX8A 2XVVA 2XW0A 4LA0A 5FUOA 2YDFA 1E7BA 5GINA 4EMXA 4F5VA 4PO0A 2BXAA 5B5TA 3SIVB 2XSIA 2XVWA 5HOZA 1O9XA 5ID7A 2Z8KA 5ID9A 2BXOA 2E0YA 5IJ5A 3TDLA 1LNSA 3WHSA 2EFCA 3FWCC 3MHSB 3SQJA 2VUFA 3M99C 5GIPA 3MHHB 3JQZA 2DBUA 2KBZA 1HA2A 5DBYA 3UIVA 2EFEA 1E7IA 3G9KD 2EFHA 1HK1A 4ZBQA 4DHXB 1HK3A 4M70B 3V09A 1HK2A 3WHQA 4LB2A 2BXDA 4GG2A 2QMCA 2DBXA 4GDLB 4OT2A 2I30A 3FWBC 2BXFA 1IJGA 2VUEA 4Z9OA 1E7FA 1GNJA 4BKEA 5IIUA 4IW2A 4WA6B 2QM6A 2CKXA 1MIVA 2BXQA 1H5WA 5IJFA 2NQOA 5BPKA 3WHRA 1BKEA 2BXNA 5GHKA 4G03A 2LOQA 5GIOA 4NAWB 1BM0A 1E7CA 1FOUA 3GQXA 4GDKB 4MBEC 4G04A 2BXBA 3KJLA 1TF0A 4N0FD 4ZC6A 4J2VA 4GDXA 4IW1A 2NNWA 1E7HA 3V08A 4OR0A 4OTUA 3GQUA 4L8UA 2XW1A 2BXHA 3KIKA 2V36A 1KW2A 3A75A 2BXCA 4K71A 2XVUA 5IIXA 1NT2B 4N0UD 3CX9A 2AJEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LUH A;  3B9M A;  1KXP D;  5DQF A;  1J7E A;  2BXG A;  1GNI A;  2BXM A;  5IFO A;  1AO6 A;  4F5U A;  2I2Z A;  2BXE A;  1HK5 A;  4E99 A;  3A73 A;  4K2C A;  4HGM B;  4HGK A;  5IJE A;  4S1Y A;  2BXP A;  4F5S A;  3LU7 A;  3LU8 A;  1J78 A;  3JRY A;  3LU6 A;  3V03 A;  4LB9 A;  1E7G A;  1UOR A;  5IIH A;  1E7A A;  4ZBR A;  2BXK A;  4L9Q A;  2BXL A;  1H9Z A;  4F5T A;  1E7E A;  2BXI A;  1E78 A;  1N5U A;  1MA9 A;  2XVQ A;  2VDB A;  1BJ5 A;  4Z69 A;  1HK4 A;  4JK4 A;  3B9L A;  4L9K A;  1LOT A;  4LUF A;  2BX8 A;  2XVV A;  2XW0 A;  4LA0 A;  5FUO A;  2YDF A;  1E7B A;  4EMX A;  4F5V A;  4PO0 A;  2BXA A;  2XSI A;  2XVW A;  5HOZ A;  1O9X A;  5ID7 A;  5ID9 A;  2BXO A;  5IJ5 A;  3TDL A;  3SQJ A;  2VUF A;  3JQZ A;  1HA2 A;  5DBY A;  3UIV A;  1E7I A;  1HK1 A;  4ZBQ A;  1HK3 A;  3V09 A;  1HK2 A;  4LB2 A;  2BXD A;  4OT2 A;  2I30 A;  2BXF A;  2VUE A;  1E7F A;  1GNJ A;  4BKE A;  5IIU A;  4IW2 A;  2BXQ A;  5IJF A;  1BKE A;  2BXN A;  5GHK A;  4G03 A;  1BM0 A;  1E7C A;  4G04 A;  2BXB A;  4N0F D;  1TF0 A;  4J2V A;  4IW1 A;  1E7H A;  3V08 A;  4OR0 A;  4L8U A;  2XW1 A;  2BXH A;  1KW2 A;  2BXC A;  4K71 A;  2XVU A;  5IIX A;  4N0U D;  3CX9 A; 
#chains in the Genus database with same CATH topology
 1MIY A;  4LUH A;  3B9M A;  3SIU B;  1KXP D;  5DQF A;  1J7E A;  2DBW A;  5D7G A;  4TQ1 A;  4TQ0 A;  2QHB A;  2BXG A;  3GA9 L;  4W4U B;  1GNI A;  4DM0 A;  2BXM A;  4FK5 B;  5IFO A;  3H37 A;  1AO6 A;  4F5U A;  2LQH A;  3NMU A;  2I2Z A;  2DYO A;  3ICX A;  3PLA A;  2BXE A;  3H3A A;  2JUH A;  2Z8J A;  1HK5 A;  2DG5 A;  4E99 A;  4G01 A;  2XMO A;  3A73 A;  4K2C A;  2OT3 A;  4HGM B;  4HGK A;  1VFI A;  3W1S A;  5IJE A;  2LXS A;  4S1Y A;  2BXP A;  4F5S A;  2LQI A;  4FIP B;  3LU7 A;  1SB0 A;  2DYM A;  3LU8 A;  4BY9 C;  2OZB B;  1MIW A;  1J78 A;  3JRY A;  3LU6 A;  3V03 A;  1JNB A;  3NVK A;  4OTT A;  4LB9 A;  1E7G A;  1UOR A;  4C31 B;  5IIH A;  2EFD A;  4FJC B;  1E7A A;  4ZBR A;  2BXK A;  4L9Q A;  1KDX A;  2Z8I A;  2E0X A;  2BXL A;  3NVI A;  1H9Z A;  4F5T A;  1E7E A;  4ZBK A;  1VZS A;  3FNM A;  2ROH A;  2BXI A;  4ZCG A;  1E78 A;  1N5U A;  3NVM A;  3VQI A;  1MA9 A;  2XVQ A;  4N3Z A;  2VDB A;  1BJ5 A;  4Z69 A;  1HK4 A;  1TXU A;  4ZUX V;  4JK4 A;  3B9L A;  4L9K A;  1LOT A;  4LUF A;  2BX8 A;  2XVV A;  2XW0 A;  4LA0 A;  5FUO A;  2YDF A;  1E7B A;  5GIN A;  4EMX A;  4F5V A;  4PO0 A;  2BXA A;  5B5T A;  3SIV B;  2XSI A;  2XVW A;  5HOZ A;  1O9X A;  5ID7 A;  2Z8K A;  5ID9 A;  2BXO A;  2E0Y A;  5IJ5 A;  3TDL A;  1LNS A;  3WHS A;  2EFC A;  3FWC C;  3MHS B;  3SQJ A;  2VUF A;  3M99 C;  5GIP A;  3MHH B;  3JQZ A;  2DBU A;  2KBZ A;  1HA2 A;  5DBY A;  1MUH A;  3UIV A;  2EFE A;  2AGH B;  1E7I A;  3G9K D;  2EFH A;  1HK1 A;  4ZBQ A;  4DHX B;  1HK3 A;  4M70 B;  3V09 A;  1HK2 A;  3WHQ A;  4LB2 A;  2BXD A;  2K0N A;  4GG2 A;  2QMC A;  2DBX A;  4GDL B;  4OT2 A;  2I30 A;  3FWB C;  2BXF A;  1IJG A;  2VUE A;  4Z9O A;  1E7F A;  1GNJ A;  4BKE A;  5IIU A;  4IW2 A;  4WA6 B;  2QM6 A;  2CKX A;  1MM8 A;  1MIV A;  2BXQ A;  1MUS A;  1H5W A;  2KWF A;  5IJF A;  2NQO A;  5BPK A;  4I9O A;  3WHR A;  1BKE A;  2BXN A;  5GHK A;  4G03 A;  2LOQ A;  5GIO A;  4NAW B;  1BM0 A;  1E7C A;  1FOU A;  3GQX A;  4GDK B;  2LXT A;  4MBE C;  4G04 A;  2BXB A;  2GUT A;  1TF0 A;  3KJL A;  4N0F D;  4ZC6 A;  3ECP A;  4J2V A;  4GDX A;  4IW1 A;  2NNW A;  1E7H A;  3BPJ A;  3V08 A;  4OR0 A;  4OTU A;  3GQU A;  4L8U A;  2XW1 A;  2BXH A;  3KIK A;  2V36 A;  1KW2 A;  3A75 A;  2BXC A;  4K71 A;  2XVU A;  5IIX A;  4D7X A;  1NT2 B;  4N0U D;  3CX9 A;  2AJE A; 
#chains in the Genus database with same CATH homology
 1MIY A;  4LUH A;  3B9M A;  3SIU B;  1KXP D;  5DQF A;  1J7E A;  2DBW A;  5D7G A;  4TQ1 A;  4TQ0 A;  2QHB A;  2BXG A;  3GA9 L;  4W4U B;  1GNI A;  2BXM A;  4FK5 B;  5IFO A;  3H37 A;  1AO6 A;  4F5U A;  3NMU A;  2I2Z A;  2DYO A;  3ICX A;  3PLA A;  2BXE A;  3H3A A;  2JUH A;  2Z8J A;  1HK5 A;  2DG5 A;  4E99 A;  4G01 A;  2XMO A;  3A73 A;  4K2C A;  2OT3 A;  4HGM B;  4HGK A;  1VFI A;  3W1S A;  5IJE A;  4S1Y A;  2BXP A;  4F5S A;  4FIP B;  3LU7 A;  2DYM A;  3LU8 A;  4BY9 C;  2OZB B;  1MIW A;  1J78 A;  3JRY A;  3LU6 A;  3V03 A;  1JNB A;  3NVK A;  4OTT A;  4LB9 A;  1E7G A;  1UOR A;  4C31 B;  5IIH A;  2EFD A;  4FJC B;  1E7A A;  4ZBR A;  2BXK A;  4L9Q A;  2Z8I A;  2E0X A;  2BXL A;  3NVI A;  1H9Z A;  4F5T A;  1E7E A;  4ZBK A;  1VZS A;  3FNM A;  2ROH A;  2BXI A;  4ZCG A;  1E78 A;  1N5U A;  3NVM A;  3VQI A;  1MA9 A;  2XVQ A;  4N3Z A;  2VDB A;  1BJ5 A;  4Z69 A;  1HK4 A;  1TXU A;  4ZUX V;  4JK4 A;  3B9L A;  4L9K A;  1LOT A;  4LUF A;  2BX8 A;  2XVV A;  2XW0 A;  4LA0 A;  5FUO A;  2YDF A;  1E7B A;  5GIN A;  4EMX A;  4F5V A;  4PO0 A;  2BXA A;  5B5T A;  3SIV B;  2XSI A;  2XVW A;  5HOZ A;  1O9X A;  5ID7 A;  2Z8K A;  5ID9 A;  2BXO A;  2E0Y A;  5IJ5 A;  3TDL A;  1LNS A;  3WHS A;  2EFC A;  3FWC C;  3MHS B;  3SQJ A;  2VUF A;  3M99 C;  5GIP A;  3MHH B;  3JQZ A;  2DBU A;  2KBZ A;  1HA2 A;  5DBY A;  3UIV A;  2EFE A;  1E7I A;  3G9K D;  2EFH A;  1HK1 A;  4ZBQ A;  4DHX B;  1HK3 A;  4M70 B;  3V09 A;  1HK2 A;  3WHQ A;  4LB2 A;  2BXD A;  4GG2 A;  2QMC A;  2DBX A;  4GDL B;  4OT2 A;  2I30 A;  3FWB C;  2BXF A;  1IJG A;  2VUE A;  4Z9O A;  1E7F A;  1GNJ A;  4BKE A;  5IIU A;  4IW2 A;  4WA6 B;  2QM6 A;  2CKX A;  1MIV A;  2BXQ A;  1H5W A;  5IJF A;  2NQO A;  5BPK A;  3WHR A;  1BKE A;  2BXN A;  5GHK A;  4G03 A;  2LOQ A;  5GIO A;  4NAW B;  1BM0 A;  1E7C A;  1FOU A;  3GQX A;  4GDK B;  4MBE C;  4G04 A;  2BXB A;  3KJL A;  1TF0 A;  4N0F D;  4ZC6 A;  4J2V A;  4GDX A;  4IW1 A;  2NNW A;  1E7H A;  3V08 A;  4OR0 A;  4OTU A;  3GQU A;  4L8U A;  2XW1 A;  2BXH A;  3KIK A;  2V36 A;  1KW2 A;  3A75 A;  2BXC A;  4K71 A;  2XVU A;  5IIX A;  1NT2 B;  4N0U D;  3CX9 A;  2AJE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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