1HK2A

Human serum albumin mutant r218h complexed with thyroxine (3,3',5,5'-tetraiodo-l-thyronine)
Total Genus 210
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
210
sequence length
572
structure length
560
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTDCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVAHLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords SERUM ALBUMIN
publication title Structural Basis of Albumin-Thyroxine Interactions and Familial Dysalbuminemic Hyperthyroxinemia
pubmed doi rcsb
source organism Homo sapiens
molecule tags Plasma protein
total genus 210
structure length 560
sequence length 572
ec nomenclature
pdb deposition date 2003-03-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A05
1UORA 1O9XA 2XVVA 4LB9A 1E7AA 2I30A 4G03A 3LU8A 3JQZA 3JRYA 1E7BA 2BXLA 1E7HA 4F5TA 5DBYA 4LB2A 1KW2A 1LOTA 2XSIA 5IJFA 5ID7A 3CX9A 5IJ5A 1J78A 2BXPA 4K71A 4BKEA 1AO6A 4IW2A 2BXKA 5HOZA 1E7CA 5ID9A 1E7IA 3SQJA 4IW1A 4L8UA 4PO0A 2BXGA 4EMXA 2BXAA 1HK2A 3UIVA 2XW1A 1BJ5A 1E7FA 4F5VA 4JK4A 1HK3A 3B9LA 1GNJA 5IIHA 4HGMB 1KXPD 2YDFA 2VDBA 5IIXA 1BKEA 2VUFA 4N0UD 1E7EA 4OT2A 1E7GA 1HK4A 4F5SA 3V03A 4Z69A 2BXHA 2VUEA 2BXMA 1HK5A 4HGKA 4N0FD 3LU6A 4F5UA 3V09A 3V08A 4G04A 4L9KA 1J7EA 1H9ZA 4LUHA 2BXCA 3TDLA 1GNIA 1BM0A 3B9MA 5IFOA 4LA0A 2BXDA 2I2ZA 5DQFA 2XVQA 5IIUA 1E78A 2BXBA 3LU7A 4S1YA 5IJEA 1HA2A 5GHKA 2BXIA 4J2VA 4K2CA 3A73A 5FUOA 2BXOA 2XW0A 2BX8A 4LUFA 1TF0A 1HK1A 2BXEA 2BXQA 4E99A 1N5UA 2BXFA 2XVWA 2BXNA 4ZBQA 1MA9A 4L9QA 4ZBRA 2XVUA 4OR0A
chains in the Genus database with same CATH superfamily
2ROHA 3G9KD 1UORA 1O9XA 2XVVA 4LB9A 1E7AA 4FJCB 2I30A 2LXSA 4G03A 3LU8A 4N3ZA 3JQZA 3JRYA 1E7BA 2BXLA 1E7HA 2DYMA 2GUTA 2QMCA 3KIKA 5DBYA 4F5TA 2DYOA 4NAWB 4LB2A 4WA6B 3GQUA 3H37A 1KW2A 4FK5B 2DBXA 1LOTA 2XSIA 5IJFA 2LQIA 5ID7A 3CX9A 5IJ5A 1MM8A 1VFIA 4ZUXV 1J78A 2BXPA 3KJLA 4K71A 4BKEA 1AO6A 4IW2A 3WHSA 1H5WA 2BXKA 1VZSA 5HOZA 1MUSA 2E0XA 3NVMA 1E7CA 5ID9A 3NVIA 2AJEA 1E7IA 3SQJA 3WHRA 2DBWA 5GIOA 2DBUA 4IW1A 4L8UA 2NQOA 3SIVB 4ZBKA 4PO0A 2BXGA 3BPJA 4EMXA 2KWFA 2QHBA 2BXAA 3H3AA 1HK2A 2CKXA 3UIVA 2XW1A 3VQIA 1BJ5A 4C31B 2DG5A 1E7FA 3WHQA 4F5VA 1LNSA 3NMUA 2Z8IA 4JK4A 1HK3A 1NT2B 3B9LA 3FNMA 1GNJA 5IIHA 4TQ0A 5GINA 1TXUA 4HGMB 1SB0A 5GIPA 2QM6A 1KXPD 4DHXB 2YDFA 2VDBA 5IIXA 1IJGA 1BKEA 2VUFA 1MIWA 3ECPA 4OTTA 4ZCGA 4N0UD 1E7EA 4OT2A 1MIYA 1E7GA 3MHHB 1HK4A 3FWBC 3M99C 4F5SA 3V03A 4Z69A 5BPKA 2Z8KA 3PLAA 2BXHA 2VUEA 5B5TA 2BXMA 1MUHA 1HK5A 4DM0A 4HGKA 4N0FD 3LU6A 4F5UA 3V09A 3V08A 4G04A 4L9KA 3W1SA 1J7EA 2LQHA 1H9ZA 4LUHA 4MBEC 4GDLB 4D7XA 2BXCA 4I9OA 4G01A 4Z9OA 3TDLA 1GNIA 1JNBA 1BM0A 2OZBB 3B9MA 2LXTA 2Z8JA 5IFOA 3GQXA 4LA0A 2BXDA 2EFEA 3GA9L 5D7GA 3NVKA 3MHSB 3SIUB 2AGHB 2I2ZA 5DQFA 3ICXA 2XVQA 5IIUA 4GG2A 4FIPB 1E78A 1MIVA 2BXBA 3LU7A 2E0YA 2OT3A 4S1YA 4ZC6A 4GDKB 1HA2A 5GHKA 5IJEA 4TQ1A 2KBZA 2NNWA 3FWCC 2BXIA 2JUHA 2K0NA 4J2VA 4K2CA 1FOUA 2V36A 3A73A 2BXOA 2EFCA 5FUOA 2EFHA 2XW0A 2BX8A 2LOQA 4LUFA 1TF0A 1HK1A 2EFDA 4BY9C 2BXEA 2BXQA 2XMOA 4W4UB 4E99A 3A75A 1N5UA 2BXFA 4OTUA 2XVWA 2BXNA 4ZBQA 1MA9A 4L9QA 4ZBRA 4GDXA 1KDXA 2XVUA 4M70B 4OR0A
chains in the Genus database with same CATH topology
2ROHA 3G9KD 1UORA 1O9XA 2XVVA 4LB9A 1E7AA 4FJCB 2I30A 4G03A 3LU8A 4N3ZA 3JQZA 3JRYA 1E7BA 2BXLA 1E7HA 2DYMA 4F5TA 2QMCA 3KIKA 5DBYA 2DYOA 4NAWB 4LB2A 4WA6B 3GQUA 3H37A 1KW2A 4FK5B 2DBXA 1LOTA 2XSIA 5IJFA 5ID7A 3CX9A 5IJ5A 1VFIA 4ZUXV 1J78A 2BXPA 3KJLA 4K71A 4BKEA 1AO6A 4IW2A 3WHSA 1H5WA 2BXKA 1VZSA 5HOZA 2E0XA 3NVMA 1E7CA 5ID9A 3NVIA 2AJEA 1E7IA 3SQJA 3WHRA 2DBWA 5GIOA 2DBUA 4IW1A 4L8UA 2NQOA 3SIVB 4ZBKA 4PO0A 2BXGA 4EMXA 2QHBA 2BXAA 3H3AA 1HK2A 2CKXA 3UIVA 2XW1A 3VQIA 1BJ5A 4C31B 2DG5A 1E7FA 3WHQA 4F5VA 1LNSA 3NMUA 2Z8IA 4JK4A 1HK3A 1NT2B 3B9LA 3FNMA 1GNJA 5IIHA 4TQ0A 5GINA 1TXUA 4HGMB 5GIPA 2QM6A 1KXPD 4DHXB 2YDFA 2VDBA 5IIXA 1IJGA 1BKEA 2VUFA 1MIWA 4OTTA 4ZCGA 4N0UD 1E7EA 4OT2A 1MIYA 1E7GA 3MHHB 1HK4A 3FWBC 3M99C 4F5SA 3V03A 4Z69A 5BPKA 2Z8KA 3PLAA 2BXHA 2VUEA 5B5TA 2BXMA 1HK5A 4HGKA 4N0FD 3LU6A 4F5UA 3V09A 3V08A 4G04A 4L9KA 3W1SA 1J7EA 1H9ZA 4LUHA 4MBEC 4GDLB 2BXCA 4Z9OA 4G01A 3TDLA 1GNIA 1JNBA 1BM0A 2OZBB 3B9MA 2Z8JA 5IFOA 3GQXA 4LA0A 2BXDA 2EFEA 3GA9L 5D7GA 3NVKA 3MHSB 3SIUB 2I2ZA 5DQFA 3ICXA 2XVQA 5IIUA 4GG2A 4FIPB 1E78A 1MIVA 2BXBA 3LU7A 2E0YA 2OT3A 4S1YA 4ZC6A 4GDKB 1HA2A 5GHKA 5IJEA 4TQ1A 2KBZA 2NNWA 3FWCC 2BXIA 2JUHA 4J2VA 4K2CA 1FOUA 2V36A 3A73A 2BXOA 2EFCA 5FUOA 2EFHA 2XW0A 2BX8A 2LOQA 4LUFA 1TF0A 1HK1A 2EFDA 4BY9C 2BXEA 2BXQA 2XMOA 4W4UB 4E99A 3A75A 1N5UA 2BXFA 4OTUA 2XVWA 2BXNA 4ZBQA 1MA9A 4L9QA 4ZBRA 4GDXA 2XVUA 4M70B 4OR0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1UOR A;  1O9X A;  2XVV A;  4LB9 A;  1E7A A;  2I30 A;  4G03 A;  3LU8 A;  3JQZ A;  3JRY A;  1E7B A;  2BXL A;  1E7H A;  4F5T A;  5DBY A;  4LB2 A;  1KW2 A;  1LOT A;  2XSI A;  5IJF A;  5ID7 A;  3CX9 A;  5IJ5 A;  1J78 A;  2BXP A;  4K71 A;  4BKE A;  1AO6 A;  4IW2 A;  2BXK A;  5HOZ A;  1E7C A;  5ID9 A;  1E7I A;  3SQJ A;  4IW1 A;  4L8U A;  4PO0 A;  2BXG A;  4EMX A;  2BXA A;  1HK2 A;  3UIV A;  2XW1 A;  1BJ5 A;  1E7F A;  4F5V A;  4JK4 A;  1HK3 A;  3B9L A;  1GNJ A;  5IIH A;  4HGM B;  1KXP D;  2YDF A;  2VDB A;  5IIX A;  1BKE A;  2VUF A;  4N0U D;  1E7E A;  4OT2 A;  1E7G A;  1HK4 A;  4F5S A;  3V03 A;  4Z69 A;  2BXH A;  2VUE A;  2BXM A;  1HK5 A;  4HGK A;  4N0F D;  3LU6 A;  4F5U A;  3V09 A;  3V08 A;  4G04 A;  4L9K A;  1J7E A;  1H9Z A;  4LUH A;  2BXC A;  3TDL A;  1GNI A;  1BM0 A;  3B9M A;  5IFO A;  4LA0 A;  2BXD A;  2I2Z A;  5DQF A;  2XVQ A;  5IIU A;  1E78 A;  2BXB A;  3LU7 A;  4S1Y A;  5IJE A;  1HA2 A;  5GHK A;  2BXI A;  4J2V A;  4K2C A;  3A73 A;  5FUO A;  2BXO A;  2XW0 A;  2BX8 A;  4LUF A;  1TF0 A;  1HK1 A;  2BXE A;  2BXQ A;  4E99 A;  1N5U A;  2BXF A;  2XVW A;  2BXN A;  4ZBQ A;  1MA9 A;  4L9Q A;  4ZBR A;  2XVU A;  4OR0 A; 
#chains in the Genus database with same CATH topology
 2ROH A;  3G9K D;  1UOR A;  1O9X A;  2XVV A;  4LB9 A;  1E7A A;  4FJC B;  2I30 A;  2LXS A;  4G03 A;  3LU8 A;  4N3Z A;  3JQZ A;  3JRY A;  1E7B A;  2BXL A;  1E7H A;  2DYM A;  2GUT A;  2QMC A;  3KIK A;  5DBY A;  4F5T A;  2DYO A;  4NAW B;  4LB2 A;  4WA6 B;  3GQU A;  3H37 A;  1KW2 A;  4FK5 B;  2DBX A;  1LOT A;  2XSI A;  5IJF A;  2LQI A;  5ID7 A;  3CX9 A;  5IJ5 A;  1MM8 A;  1VFI A;  4ZUX V;  1J78 A;  2BXP A;  3KJL A;  4K71 A;  4BKE A;  1AO6 A;  4IW2 A;  3WHS A;  1H5W A;  2BXK A;  1VZS A;  5HOZ A;  1MUS A;  2E0X A;  3NVM A;  1E7C A;  5ID9 A;  3NVI A;  2AJE A;  1E7I A;  3SQJ A;  3WHR A;  2DBW A;  5GIO A;  2DBU A;  4IW1 A;  4L8U A;  2NQO A;  3SIV B;  4ZBK A;  4PO0 A;  2BXG A;  3BPJ A;  4EMX A;  2KWF A;  2QHB A;  2BXA A;  3H3A A;  1HK2 A;  2CKX A;  3UIV A;  2XW1 A;  3VQI A;  1BJ5 A;  4C31 B;  2DG5 A;  1E7F A;  3WHQ A;  4F5V A;  1LNS A;  3NMU A;  2Z8I A;  4JK4 A;  1HK3 A;  1NT2 B;  3B9L A;  3FNM A;  1GNJ A;  5IIH A;  4TQ0 A;  5GIN A;  1TXU A;  4HGM B;  1SB0 A;  5GIP A;  2QM6 A;  1KXP D;  4DHX B;  2YDF A;  2VDB A;  5IIX A;  1IJG A;  1BKE A;  2VUF A;  1MIW A;  3ECP A;  4OTT A;  4ZCG A;  4N0U D;  1E7E A;  4OT2 A;  1MIY A;  1E7G A;  3MHH B;  1HK4 A;  3FWB C;  3M99 C;  4F5S A;  3V03 A;  4Z69 A;  5BPK A;  2Z8K A;  3PLA A;  2BXH A;  2VUE A;  5B5T A;  2BXM A;  1MUH A;  1HK5 A;  4DM0 A;  4HGK A;  4N0F D;  3LU6 A;  4F5U A;  3V09 A;  3V08 A;  4G04 A;  4L9K A;  3W1S A;  1J7E A;  2LQH A;  1H9Z A;  4LUH A;  4MBE C;  4GDL B;  4D7X A;  2BXC A;  4I9O A;  4G01 A;  4Z9O A;  3TDL A;  1GNI A;  1JNB A;  1BM0 A;  2OZB B;  3B9M A;  2LXT A;  2Z8J A;  5IFO A;  3GQX A;  4LA0 A;  2BXD A;  2EFE A;  3GA9 L;  5D7G A;  3NVK A;  3MHS B;  3SIU B;  2AGH B;  2I2Z A;  5DQF A;  3ICX A;  2XVQ A;  5IIU A;  4GG2 A;  4FIP B;  1E78 A;  1MIV A;  2BXB A;  3LU7 A;  2E0Y A;  2OT3 A;  4S1Y A;  4ZC6 A;  4GDK B;  1HA2 A;  5GHK A;  5IJE A;  4TQ1 A;  2KBZ A;  2NNW A;  3FWC C;  2BXI A;  2JUH A;  2K0N A;  4J2V A;  4K2C A;  1FOU A;  2V36 A;  3A73 A;  2BXO A;  2EFC A;  5FUO A;  2EFH A;  2XW0 A;  2BX8 A;  2LOQ A;  4LUF A;  1TF0 A;  1HK1 A;  2EFD A;  4BY9 C;  2BXE A;  2BXQ A;  2XMO A;  4W4U B;  4E99 A;  3A75 A;  1N5U A;  2BXF A;  4OTU A;  2XVW A;  2BXN A;  4ZBQ A;  1MA9 A;  4L9Q A;  4ZBR A;  4GDX A;  1KDX A;  2XVU A;  4M70 B;  4OR0 A; 
#chains in the Genus database with same CATH homology
 2ROH A;  3G9K D;  1UOR A;  1O9X A;  2XVV A;  4LB9 A;  1E7A A;  4FJC B;  2I30 A;  4G03 A;  3LU8 A;  4N3Z A;  3JQZ A;  3JRY A;  1E7B A;  2BXL A;  1E7H A;  2DYM A;  4F5T A;  2QMC A;  3KIK A;  5DBY A;  2DYO A;  4NAW B;  4LB2 A;  4WA6 B;  3GQU A;  3H37 A;  1KW2 A;  4FK5 B;  2DBX A;  1LOT A;  2XSI A;  5IJF A;  5ID7 A;  3CX9 A;  5IJ5 A;  1VFI A;  4ZUX V;  1J78 A;  2BXP A;  3KJL A;  4K71 A;  4BKE A;  1AO6 A;  4IW2 A;  3WHS A;  1H5W A;  2BXK A;  1VZS A;  5HOZ A;  2E0X A;  3NVM A;  1E7C A;  5ID9 A;  3NVI A;  2AJE A;  1E7I A;  3SQJ A;  3WHR A;  2DBW A;  5GIO A;  2DBU A;  4IW1 A;  4L8U A;  2NQO A;  3SIV B;  4ZBK A;  4PO0 A;  2BXG A;  4EMX A;  2QHB A;  2BXA A;  3H3A A;  1HK2 A;  2CKX A;  3UIV A;  2XW1 A;  3VQI A;  1BJ5 A;  4C31 B;  2DG5 A;  1E7F A;  3WHQ A;  4F5V A;  1LNS A;  3NMU A;  2Z8I A;  4JK4 A;  1HK3 A;  1NT2 B;  3B9L A;  3FNM A;  1GNJ A;  5IIH A;  4TQ0 A;  5GIN A;  1TXU A;  4HGM B;  5GIP A;  2QM6 A;  1KXP D;  4DHX B;  2YDF A;  2VDB A;  5IIX A;  1IJG A;  1BKE A;  2VUF A;  1MIW A;  4OTT A;  4ZCG A;  4N0U D;  1E7E A;  4OT2 A;  1MIY A;  1E7G A;  3MHH B;  1HK4 A;  3FWB C;  3M99 C;  4F5S A;  3V03 A;  4Z69 A;  5BPK A;  2Z8K A;  3PLA A;  2BXH A;  2VUE A;  5B5T A;  2BXM A;  1HK5 A;  4HGK A;  4N0F D;  3LU6 A;  4F5U A;  3V09 A;  3V08 A;  4G04 A;  4L9K A;  3W1S A;  1J7E A;  1H9Z A;  4LUH A;  4MBE C;  4GDL B;  2BXC A;  4Z9O A;  4G01 A;  3TDL A;  1GNI A;  1JNB A;  1BM0 A;  2OZB B;  3B9M A;  2Z8J A;  5IFO A;  3GQX A;  4LA0 A;  2BXD A;  2EFE A;  3GA9 L;  5D7G A;  3NVK A;  3MHS B;  3SIU B;  2I2Z A;  5DQF A;  3ICX A;  2XVQ A;  5IIU A;  4GG2 A;  4FIP B;  1E78 A;  1MIV A;  2BXB A;  3LU7 A;  2E0Y A;  2OT3 A;  4S1Y A;  4ZC6 A;  4GDK B;  1HA2 A;  5GHK A;  5IJE A;  4TQ1 A;  2KBZ A;  2NNW A;  3FWC C;  2BXI A;  2JUH A;  4J2V A;  4K2C A;  1FOU A;  2V36 A;  3A73 A;  2BXO A;  2EFC A;  5FUO A;  2EFH A;  2XW0 A;  2BX8 A;  2LOQ A;  4LUF A;  1TF0 A;  1HK1 A;  2EFD A;  4BY9 C;  2BXE A;  2BXQ A;  2XMO A;  4W4U B;  4E99 A;  3A75 A;  1N5U A;  2BXF A;  4OTU A;  2XVW A;  2BXN A;  4ZBQ A;  1MA9 A;  4L9Q A;  4ZBR A;  4GDX A;  2XVU A;  4M70 B;  4OR0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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