1HK2A

Human serum albumin mutant r218h complexed with thyroxine (3,3',5,5'-tetraiodo-l-thyronine)
Total Genus 210
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
210
sequence length
572
structure length
560
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTDCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVAHLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis of Albumin-Thyroxine Interactions and Familial Dysalbuminemic Hyperthyroxinemia
pubmed doi rcsb
molecule keywords SERUM ALBUMIN
molecule tags Plasma protein
source organism Homo sapiens
total genus 210
structure length 560
sequence length 572
ec nomenclature
pdb deposition date 2003-03-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A05
2BX8A 5DBYA 2BXHA 4K71A 1TF0A 3V09A 2XVQA 3LU7A 1LOTA 2BXKA 5FUOA 5DQFA 2XVUA 4E99A 2BXPA 5IJEA 1GNIA 3JRYA 4S1YA 1HK3A 1E7FA 4Z69A 5IIXA 4LB9A 1E7GA 1UORA 2XVVA 1E7CA 1J7EA 1BJ5A 2XW0A 5IFOA 4K2CA 1HK1A 2BXBA 1E7IA 5IJFA 5ID9A 2BXFA 4JK4A 4HGKA 2I30A 4EMXA 1GNJA 5HOZA 4L9KA 1E78A 3V08A 4G03A 1HK2A 4N0UD 2YDFA 1E7HA 4LA0A 4LUHA 4F5VA 5IIUA 4ZBQA 1HK4A 4G04A 2BXLA 4LUFA 1HK5A 2BXOA 2XW1A 4BKEA 5ID7A 2BXMA 4OR0A 4L8UA 3B9LA 2VDBA 4OT2A 1J78A 4LB2A 4L9QA 2BXAA 2BXQA 4IW2A 3SQJA 5IIHA 1BM0A 2BXGA 4PO0A 2BXDA 1E7AA 5IJ5A 4F5SA 3TDLA 2BXCA 3A73A 4ZBRA 1O9XA 3CX9A 3LU6A 1BKEA 2VUFA 4IW1A 1E7EA 1KW2A 2BXEA 3LU8A 5GHKA 1HA2A 2BXIA 1AO6A 1H9ZA 4HGMB 1KXPD 1N5UA 2XSIA 4N0FD 2I2ZA 4F5TA 1E7BA 3B9MA 1MA9A 3UIVA 2BXNA 3JQZA 4J2VA 3V03A 4F5UA 2VUEA 2XVWA
chains in the Genus database with same CATH superfamily
2LXSA 2BX8A 2DBXA 2QMCA 2AJEA 5DBYA 4NAWB 2BXHA 4ZUXV 4K71A 1TF0A 4FJCB 4MBEC 4OTTA 3V09A 2XVQA 3W1SA 3LU7A 1LOTA 2BXKA 4G01A 5FUOA 1IJGA 5DQFA 1MM8A 3MHSB 3GQUA 5GIPA 2XVUA 4E99A 2BXPA 5IJEA 1KDXA 3WHSA 2JUHA 4FK5B 1GNIA 4WA6B 4W4UB 5GIOA 3JRYA 4S1YA 3WHRA 1HK3A 3KJLA 4GG2A 1E7FA 4Z69A 5IIXA 4LB9A 4ZC6A 1E7GA 3WHQA 4C31B 1UORA 1MIWA 2XVVA 1E7CA 4GDXA 1J7EA 1BJ5A 4TQ0A 4DM0A 2KWFA 2XW0A 5IFOA 1MUHA 2V36A 3NVKA 3G9KD 1HK1A 2BXBA 1E7IA 2LXTA 4K2CA 5BPKA 2AGHB 5ID9A 2LOQA 2BXFA 3BPJA 4JK4A 3ICXA 4HGKA 5IJFA 3ECPA 2E0XA 1MIVA 2I30A 4EMXA 1GNJA 5HOZA 4L9KA 1E78A 3V08A 5GINA 2LQHA 4G03A 1HK2A 4N0UD 4OTUA 2DG5A 4ZBKA 2NQOA 2YDFA 1E7HA 2EFHA 2Z8JA 4LA0A 1MIYA 2QM6A 4LUHA 4F5VA 5IIUA 1SB0A 1VZSA 4ZBQA 3VQIA 2EFCA 1HK4A 4G04A 2BXLA 4LUFA 1HK5A 4GDKB 2ROHA 2BXOA 2XW1A 3GQXA 4BKEA 5ID7A 2BXMA 4OR0A 3M99C 4L8UA 2QHBA 3B9LA 4ZCGA 2VDBA 4OT2A 1J78A 2CKXA 4LB2A 4L9QA 3NMUA 2BXAA 1FOUA 2BXQA 4IW2A 3SQJA 1MUSA 5IIHA 1BM0A 2BXGA 1JNBA 1NT2B 2DBWA 1VFIA 4PO0A 3NVIA 3SIVB 2BXDA 4BY9C 3MHHB 4TQ1A 3SIUB 2DBUA 1E7AA 5IJ5A 4F5SA 3FWCC 2BXCA 3TDLA 4I9OA 2DYMA 3A73A 4ZBRA 1O9XA 2E0YA 3CX9A 2OZBB 2DYOA 2LQIA 3A75A 2GUTA 3KIKA 3LU6A 3PLAA 4FIPB 4D7XA 1BKEA 2Z8IA 2VUFA 2EFEA 4IW1A 1LNSA 3NVMA 4DHXB 1E7EA 2EFDA 2OT3A 1KW2A 2Z8KA 1H5WA 2BXEA 3H3AA 3GA9L 3LU8A 5GHKA 1HA2A 2BXIA 3FNMA 4N3ZA 1AO6A 5B5TA 1H9ZA 2K0NA 1KXPD 4HGMB 2NNWA 1N5UA 2XSIA 4N0FD 1TXUA 2I2ZA 2XMOA 4F5TA 1E7BA 2KBZA 3B9MA 3FWBC 1MA9A 3UIVA 4M70B 2BXNA 3JQZA 4J2VA 3V03A 5D7GA 4Z9OA 4F5UA 3H37A 2VUEA 4GDLB 2XVWA
chains in the Genus database with same CATH topology
2BX8A 2DBXA 2QMCA 2AJEA 5DBYA 4NAWB 2BXHA 4ZUXV 4K71A 1TF0A 4FJCB 4MBEC 4OTTA 3V09A 2XVQA 3W1SA 3LU7A 1LOTA 2BXKA 4G01A 5FUOA 1IJGA 5DQFA 3MHSB 3GQUA 5GIPA 2XVUA 4E99A 2BXPA 5IJEA 3WHSA 2JUHA 4FK5B 1GNIA 4WA6B 4W4UB 5GIOA 3JRYA 4S1YA 3WHRA 1HK3A 3KJLA 4GG2A 1E7FA 4Z69A 5IIXA 4LB9A 4ZC6A 1E7GA 3WHQA 4C31B 1UORA 1MIWA 2XVVA 1E7CA 4GDXA 1J7EA 1BJ5A 4TQ0A 2XW0A 5IFOA 2V36A 3NVKA 3G9KD 1HK1A 2BXBA 1E7IA 4K2CA 5BPKA 5IJFA 5ID9A 2LOQA 2BXFA 4JK4A 3ICXA 4HGKA 2E0XA 1MIVA 2I30A 4EMXA 1GNJA 5HOZA 4L9KA 1E78A 3V08A 5GINA 4G03A 1HK2A 4N0UD 4OTUA 2DG5A 4ZBKA 2NQOA 2YDFA 1E7HA 2EFHA 2Z8JA 4LA0A 1MIYA 2QM6A 4LUHA 4F5VA 5IIUA 1VZSA 4ZBQA 3VQIA 2EFCA 1HK4A 4G04A 2BXLA 4LUFA 1HK5A 4GDKB 2ROHA 2BXOA 2XW1A 3GQXA 4BKEA 5ID7A 2BXMA 4OR0A 3M99C 4L8UA 2QHBA 3B9LA 4ZCGA 2VDBA 4OT2A 1J78A 2CKXA 4LB2A 4L9QA 3NMUA 2BXAA 1FOUA 2BXQA 4IW2A 3SQJA 5IIHA 1BM0A 2BXGA 1JNBA 1NT2B 2DBWA 1VFIA 4PO0A 3NVIA 3SIVB 2BXDA 4BY9C 3MHHB 4TQ1A 3SIUB 2DBUA 1E7AA 5IJ5A 4F5SA 3FWCC 2BXCA 3TDLA 2DYMA 3A73A 4ZBRA 1O9XA 2E0YA 3CX9A 2OZBB 2DYOA 3A75A 3KIKA 3LU6A 3PLAA 4FIPB 1BKEA 2Z8IA 2VUFA 2EFEA 4IW1A 1LNSA 3NVMA 4DHXB 1E7EA 2EFDA 2OT3A 1KW2A 2Z8KA 1H5WA 2BXEA 3H3AA 3GA9L 3LU8A 5GHKA 1HA2A 2BXIA 3FNMA 4N3ZA 1AO6A 5B5TA 1H9ZA 4HGMB 1KXPD 2NNWA 1N5UA 2XSIA 4N0FD 1TXUA 2I2ZA 2XMOA 4F5TA 1E7BA 2KBZA 3B9MA 3FWBC 1MA9A 3UIVA 4M70B 2BXNA 3JQZA 4J2VA 3V03A 5D7GA 4Z9OA 4F5UA 3H37A 2VUEA 4GDLB 2XVWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BX8 A;  5DBY A;  2BXH A;  4K71 A;  1TF0 A;  3V09 A;  2XVQ A;  3LU7 A;  1LOT A;  2BXK A;  5FUO A;  5DQF A;  2XVU A;  4E99 A;  2BXP A;  5IJE A;  1GNI A;  3JRY A;  4S1Y A;  1HK3 A;  1E7F A;  4Z69 A;  5IIX A;  4LB9 A;  1E7G A;  1UOR A;  2XVV A;  1E7C A;  1J7E A;  1BJ5 A;  2XW0 A;  5IFO A;  4K2C A;  1HK1 A;  2BXB A;  1E7I A;  5IJF A;  5ID9 A;  2BXF A;  4JK4 A;  4HGK A;  2I30 A;  4EMX A;  1GNJ A;  5HOZ A;  4L9K A;  1E78 A;  3V08 A;  4G03 A;  1HK2 A;  4N0U D;  2YDF A;  1E7H A;  4LA0 A;  4LUH A;  4F5V A;  5IIU A;  4ZBQ A;  1HK4 A;  4G04 A;  2BXL A;  4LUF A;  1HK5 A;  2BXO A;  2XW1 A;  4BKE A;  5ID7 A;  2BXM A;  4OR0 A;  4L8U A;  3B9L A;  2VDB A;  4OT2 A;  1J78 A;  4LB2 A;  4L9Q A;  2BXA A;  2BXQ A;  4IW2 A;  3SQJ A;  5IIH A;  1BM0 A;  2BXG A;  4PO0 A;  2BXD A;  1E7A A;  5IJ5 A;  4F5S A;  3TDL A;  2BXC A;  3A73 A;  4ZBR A;  1O9X A;  3CX9 A;  3LU6 A;  1BKE A;  2VUF A;  4IW1 A;  1E7E A;  1KW2 A;  2BXE A;  3LU8 A;  5GHK A;  1HA2 A;  2BXI A;  1AO6 A;  1H9Z A;  4HGM B;  1KXP D;  1N5U A;  2XSI A;  4N0F D;  2I2Z A;  4F5T A;  1E7B A;  3B9M A;  1MA9 A;  3UIV A;  2BXN A;  3JQZ A;  4J2V A;  3V03 A;  4F5U A;  2VUE A;  2XVW A; 
#chains in the Genus database with same CATH topology
 2LXS A;  2BX8 A;  2DBX A;  2QMC A;  2AJE A;  5DBY A;  4NAW B;  2BXH A;  4ZUX V;  4K71 A;  1TF0 A;  4FJC B;  4MBE C;  4OTT A;  3V09 A;  2XVQ A;  3W1S A;  3LU7 A;  1LOT A;  2BXK A;  4G01 A;  5FUO A;  1IJG A;  5DQF A;  1MM8 A;  3MHS B;  3GQU A;  5GIP A;  2XVU A;  4E99 A;  2BXP A;  5IJE A;  1KDX A;  3WHS A;  2JUH A;  4FK5 B;  1GNI A;  4WA6 B;  4W4U B;  5GIO A;  3JRY A;  4S1Y A;  3WHR A;  1HK3 A;  3KJL A;  4GG2 A;  1E7F A;  4Z69 A;  5IIX A;  4LB9 A;  4ZC6 A;  1E7G A;  3WHQ A;  4C31 B;  1UOR A;  1MIW A;  2XVV A;  1E7C A;  4GDX A;  1J7E A;  1BJ5 A;  4TQ0 A;  4DM0 A;  2KWF A;  2XW0 A;  5IFO A;  1MUH A;  2V36 A;  3NVK A;  3G9K D;  1HK1 A;  2BXB A;  1E7I A;  2LXT A;  4K2C A;  5BPK A;  2AGH B;  5ID9 A;  2LOQ A;  2BXF A;  3BPJ A;  4JK4 A;  3ICX A;  4HGK A;  5IJF A;  3ECP A;  2E0X A;  1MIV A;  2I30 A;  4EMX A;  1GNJ A;  5HOZ A;  4L9K A;  1E78 A;  3V08 A;  5GIN A;  2LQH A;  4G03 A;  1HK2 A;  4N0U D;  4OTU A;  2DG5 A;  4ZBK A;  2NQO A;  2YDF A;  1E7H A;  2EFH A;  2Z8J A;  4LA0 A;  1MIY A;  2QM6 A;  4LUH A;  4F5V A;  5IIU A;  1SB0 A;  1VZS A;  4ZBQ A;  3VQI A;  2EFC A;  1HK4 A;  4G04 A;  2BXL A;  4LUF A;  1HK5 A;  4GDK B;  2ROH A;  2BXO A;  2XW1 A;  3GQX A;  4BKE A;  5ID7 A;  2BXM A;  4OR0 A;  3M99 C;  4L8U A;  2QHB A;  3B9L A;  4ZCG A;  2VDB A;  4OT2 A;  1J78 A;  2CKX A;  4LB2 A;  4L9Q A;  3NMU A;  2BXA A;  1FOU A;  2BXQ A;  4IW2 A;  3SQJ A;  1MUS A;  5IIH A;  1BM0 A;  2BXG A;  1JNB A;  1NT2 B;  2DBW A;  1VFI A;  4PO0 A;  3NVI A;  3SIV B;  2BXD A;  4BY9 C;  3MHH B;  4TQ1 A;  3SIU B;  2DBU A;  1E7A A;  5IJ5 A;  4F5S A;  3FWC C;  2BXC A;  3TDL A;  4I9O A;  2DYM A;  3A73 A;  4ZBR A;  1O9X A;  2E0Y A;  3CX9 A;  2OZB B;  2DYO A;  2LQI A;  3A75 A;  2GUT A;  3KIK A;  3LU6 A;  3PLA A;  4FIP B;  4D7X A;  1BKE A;  2Z8I A;  2VUF A;  2EFE A;  4IW1 A;  1LNS A;  3NVM A;  4DHX B;  1E7E A;  2EFD A;  2OT3 A;  1KW2 A;  2Z8K A;  1H5W A;  2BXE A;  3H3A A;  3GA9 L;  3LU8 A;  5GHK A;  1HA2 A;  2BXI A;  3FNM A;  4N3Z A;  1AO6 A;  5B5T A;  1H9Z A;  2K0N A;  1KXP D;  4HGM B;  2NNW A;  1N5U A;  2XSI A;  4N0F D;  1TXU A;  2I2Z A;  2XMO A;  4F5T A;  1E7B A;  2KBZ A;  3B9M A;  3FWB C;  1MA9 A;  3UIV A;  4M70 B;  2BXN A;  3JQZ A;  4J2V A;  3V03 A;  5D7G A;  4Z9O A;  4F5U A;  3H37 A;  2VUE A;  4GDL B;  2XVW A; 
#chains in the Genus database with same CATH homology
 2BX8 A;  2DBX A;  2QMC A;  2AJE A;  5DBY A;  4NAW B;  2BXH A;  4ZUX V;  4K71 A;  1TF0 A;  4FJC B;  4MBE C;  4OTT A;  3V09 A;  2XVQ A;  3W1S A;  3LU7 A;  1LOT A;  2BXK A;  4G01 A;  5FUO A;  1IJG A;  5DQF A;  3MHS B;  3GQU A;  5GIP A;  2XVU A;  4E99 A;  2BXP A;  5IJE A;  3WHS A;  2JUH A;  4FK5 B;  1GNI A;  4WA6 B;  4W4U B;  5GIO A;  3JRY A;  4S1Y A;  3WHR A;  1HK3 A;  3KJL A;  4GG2 A;  1E7F A;  4Z69 A;  5IIX A;  4LB9 A;  4ZC6 A;  1E7G A;  3WHQ A;  4C31 B;  1UOR A;  1MIW A;  2XVV A;  1E7C A;  4GDX A;  1J7E A;  1BJ5 A;  4TQ0 A;  2XW0 A;  5IFO A;  2V36 A;  3NVK A;  3G9K D;  1HK1 A;  2BXB A;  1E7I A;  4K2C A;  5BPK A;  5IJF A;  5ID9 A;  2LOQ A;  2BXF A;  4JK4 A;  3ICX A;  4HGK A;  2E0X A;  1MIV A;  2I30 A;  4EMX A;  1GNJ A;  5HOZ A;  4L9K A;  1E78 A;  3V08 A;  5GIN A;  4G03 A;  1HK2 A;  4N0U D;  4OTU A;  2DG5 A;  4ZBK A;  2NQO A;  2YDF A;  1E7H A;  2EFH A;  2Z8J A;  4LA0 A;  1MIY A;  2QM6 A;  4LUH A;  4F5V A;  5IIU A;  1VZS A;  4ZBQ A;  3VQI A;  2EFC A;  1HK4 A;  4G04 A;  2BXL A;  4LUF A;  1HK5 A;  4GDK B;  2ROH A;  2BXO A;  2XW1 A;  3GQX A;  4BKE A;  5ID7 A;  2BXM A;  4OR0 A;  3M99 C;  4L8U A;  2QHB A;  3B9L A;  4ZCG A;  2VDB A;  4OT2 A;  1J78 A;  2CKX A;  4LB2 A;  4L9Q A;  3NMU A;  2BXA A;  1FOU A;  2BXQ A;  4IW2 A;  3SQJ A;  5IIH A;  1BM0 A;  2BXG A;  1JNB A;  1NT2 B;  2DBW A;  1VFI A;  4PO0 A;  3NVI A;  3SIV B;  2BXD A;  4BY9 C;  3MHH B;  4TQ1 A;  3SIU B;  2DBU A;  1E7A A;  5IJ5 A;  4F5S A;  3FWC C;  2BXC A;  3TDL A;  2DYM A;  3A73 A;  4ZBR A;  1O9X A;  2E0Y A;  3CX9 A;  2OZB B;  2DYO A;  3A75 A;  3KIK A;  3LU6 A;  3PLA A;  4FIP B;  1BKE A;  2Z8I A;  2VUF A;  2EFE A;  4IW1 A;  1LNS A;  3NVM A;  4DHX B;  1E7E A;  2EFD A;  2OT3 A;  1KW2 A;  2Z8K A;  1H5W A;  2BXE A;  3H3A A;  3GA9 L;  3LU8 A;  5GHK A;  1HA2 A;  2BXI A;  3FNM A;  4N3Z A;  1AO6 A;  5B5T A;  1H9Z A;  4HGM B;  1KXP D;  2NNW A;  1N5U A;  2XSI A;  4N0F D;  1TXU A;  2I2Z A;  2XMO A;  4F5T A;  1E7B A;  2KBZ A;  3B9M A;  3FWB C;  1MA9 A;  3UIV A;  4M70 B;  2BXN A;  3JQZ A;  4J2V A;  3V03 A;  5D7G A;  4Z9O A;  4F5U A;  3H37 A;  2VUE A;  4GDL B;  2XVW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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