1HK4A

Human serum albumin complexed with thyroxine (3,3',5,5'-tetraiodo-l-thyronine) and myristic acid (tetradecanoic acid)
Total Genus 225
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
225
sequence length
582
structure length
582
Chain Sequence
HKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords SERUM ALBUMIN
publication title Structural Basis of Albumin-Thyroxine Interactions and Familial Dysalbuminemic Hyperthyroxinemia
pubmed doi rcsb
source organism Homo sapiens
molecule tags Plasma protein
total genus 225
structure length 582
sequence length 582
ec nomenclature
pdb deposition date 2003-03-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk4A03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk4A02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk4A04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk4A01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk4A06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk4A05
4ZBQA 4LUFA 3LU8A 1HK4A 1UORA 4Z69A 1E7AA 2BXLA 3JQZA 1BM0A 3LU6A 1TF0A 1BJ5A 2XW1A 3V08A 5IIUA 5FUOA 3B9LA 1O9XA 4IW2A 3UIVA 5ID9A 2I2ZA 1E7EA 1N5UA 2XVUA 1E7CA 3CX9A 1KXPD 1HK1A 2BXGA 2BXFA 1GNIA 2BXHA 4F5UA 1KW2A 4G04A 4HGMB 2XVWA 2BXNA 4E99A 2BXOA 5IJ5A 2BXAA 1MA9A 2XVVA 5IJFA 5IIHA 2BXBA 5HOZA 2VUFA 4LA0A 4LUHA 1J78A 3TDLA 2BXEA 5IJEA 4HGKA 4IW1A 2VDBA 2BXDA 4S1YA 2XVQA 2XW0A 4PO0A 1BKEA 4J2VA 1E7GA 1E7FA 2VUEA 1GNJA 5IIXA 1E7IA 3JRYA 3V03A 4K71A 4ZBRA 2YDFA 4F5TA 5DQFA 4L9QA 1LOTA 2BXPA 3LU7A 4LB2A 4F5SA 5ID7A 2BX8A 3B9MA 5GHKA 4EMXA 2BXKA 5IFOA 4LB9A 1E78A 4N0FD 2BXQA 1E7HA 1HK2A 1HK5A 1AO6A 1H9ZA 2BXIA 2I30A 4L9KA 4L8UA 1HK3A 1E7BA 4JK4A 3SQJA 4OT2A 5DBYA 3A73A 4OR0A 2BXMA 1J7EA 4F5VA 2XSIA 2BXCA 4G03A 4N0UD 4K2CA 3V09A 4BKEA 1HA2A
chains in the Genus database with same CATH superfamily
3ICXA 4ZBQA 4WA6B 4LUFA 3NVIA 4GDXA 2DYMA 3LU8A 1HK4A 1UORA 2Z8IA 4TQ1A 1E7AA 2BXLA 3FWCC 4ZCGA 3JQZA 4C31B 4Z69A 1BM0A 4Z9OA 3LU6A 1TF0A 3SIUB 5D7GA 1BJ5A 2XW1A 4G01A 3V08A 4TQ0A 5IIUA 4OTUA 2ROHA 2OZBB 5FUOA 3B9LA 1O9XA 4IW2A 1MUHA 3UIVA 5ID9A 2I2ZA 1LNSA 1E7EA 1N5UA 2XVUA 1E7CA 2CKXA 3CX9A 1H5WA 2EFDA 1KXPD 2XMOA 4BKEA 3VQIA 1HK1A 2LXTA 2BXGA 1IJGA 2BXFA 2Z8JA 4FJCB 4GDLB 3W1SA 1GNIA 1KDXA 2BXHA 2EFCA 4F5UA 1KW2A 4G04A 4HGMB 4OTTA 2XVWA 4ZC6A 3ECPA 2BXNA 4E99A 3MHHB 2BXOA 2GUTA 3KJLA 5IJ5A 2BXAA 1MA9A 5GIOA 2XVVA 5IJFA 5IIHA 2NQOA 4BY9C 2BXBA 2DBWA 5HOZA 2DBUA 2VUFA 4LA0A 4LUHA 4NAWB 1J78A 3TDLA 2LQHA 2BXEA 5IJEA 4HGKA 1TXUA 3FNMA 2LQIA 3H37A 1VFIA 3H3AA 1FOUA 3BPJA 4IW1A 3WHQA 2BXDA 2VDBA 4S1YA 3WHSA 2XVQA 2XW0A 4PO0A 2AJEA 1BKEA 4J2VA 1E7GA 1E7FA 2VUEA 3G9KD 3M99C 5B5TA 2QMCA 1GNJA 5IIXA 3A75A 4W4UB 1JNBA 4MBEC 2AGHB 1E7IA 3JRYA 3V03A 4N3ZA 2Z8KA 4K71A 4ZBRA 2YDFA 4F5TA 2KWFA 5DQFA 4L9QA 1MM8A 1LOTA 2BXPA 3LU7A 4LB2A 4F5SA 5ID7A 2BX8A 3B9MA 5GHKA 4EMXA 2BXKA 2QM6A 4I9OA 4ZBKA 4LB9A 5IFOA 1E78A 3SIVB 1MUSA 1NT2B 3GQXA 4N0FD 2BXQA 1MIWA 1E7HA 3PLAA 2E0YA 3NVMA 1HK2A 1HK5A 3GQUA 1AO6A 1H9ZA 2LXSA 2BXIA 2I30A 1MIYA 4L9KA 4DM0A 4L8UA 1HK3A 1E7BA 4GDKB 3WHRA 2KBZA 2DG5A 1SB0A 4D7XA 2JUHA 3NVKA 4JK4A 3SQJA 2K0NA 3MHSB 4OT2A 4GG2A 5DBYA 1VZSA 2NNWA 5GIPA 2OT3A 1MIVA 3A73A 4OR0A 4FIPB 2BXMA 2E0XA 5BPKA 1J7EA 2EFHA 4FK5B 4F5VA 2LOQA 2DYOA 2XSIA 2V36A 2BXCA 4ZUXV 3NMUA 4DHXB 3KIKA 5GINA 2QHBA 2EFEA 4G03A 4N0UD 4M70B 4K2CA 2DBXA 3GA9L 3V09A 3FWBC 1HA2A
chains in the Genus database with same CATH topology
3ICXA 4ZBQA 4WA6B 4LUFA 3NVIA 4GDXA 2DYMA 3LU8A 1HK4A 1UORA 2Z8IA 4TQ1A 1E7AA 2BXLA 3FWCC 4ZCGA 3JQZA 4C31B 4Z69A 1BM0A 4Z9OA 3LU6A 1TF0A 3SIUB 5D7GA 1BJ5A 2XW1A 4G01A 3V08A 4TQ0A 5IIUA 4OTUA 2ROHA 2OZBB 5FUOA 3B9LA 1O9XA 4IW2A 3UIVA 5ID9A 2I2ZA 1LNSA 1E7EA 1N5UA 2XVUA 1E7CA 2CKXA 3CX9A 1H5WA 2EFDA 1KXPD 2XMOA 4BKEA 3VQIA 1HK1A 4FJCB 2BXGA 1IJGA 2BXFA 2Z8JA 3W1SA 4GDLB 1GNIA 2BXHA 2EFCA 4F5UA 1KW2A 4G04A 4HGMB 4OTTA 2XVWA 4ZC6A 2BXNA 4E99A 3MHHB 2BXOA 3KJLA 5IJ5A 2BXAA 1MA9A 5GIOA 2XVVA 5IJFA 5IIHA 2NQOA 2BXBA 2DBWA 5HOZA 2DBUA 2VUFA 4LA0A 4LUHA 4NAWB 1J78A 3TDLA 2BXEA 5IJEA 4HGKA 1TXUA 3FNMA 3H37A 3H3AA 1VFIA 4BY9C 1FOUA 4IW1A 3WHQA 2BXDA 2VDBA 4S1YA 3WHSA 2XVQA 2XW0A 4PO0A 2AJEA 1BKEA 4J2VA 1E7GA 1E7FA 2VUEA 3G9KD 3M99C 5B5TA 2QMCA 1GNJA 5IIXA 3A75A 4W4UB 1JNBA 4MBEC 1E7IA 3JRYA 3V03A 4N3ZA 2Z8KA 4K71A 4ZBRA 2YDFA 4F5TA 5DQFA 4L9QA 1LOTA 2BXPA 3LU7A 4LB2A 4F5SA 5ID7A 2BX8A 3B9MA 5GHKA 4EMXA 2BXKA 2QM6A 4ZBKA 5IFOA 4LB9A 1E78A 3SIVB 1NT2B 3GQXA 4N0FD 2BXQA 1MIWA 1E7HA 3PLAA 2E0YA 3NVMA 1HK2A 1HK5A 3GQUA 1AO6A 1H9ZA 2BXIA 2I30A 1MIYA 4L9KA 4L8UA 1HK3A 1E7BA 4GDKB 3WHRA 2KBZA 2DG5A 2JUHA 3NVKA 4JK4A 3SQJA 3MHSB 4OT2A 4GG2A 5DBYA 1VZSA 2NNWA 5GIPA 2OT3A 1MIVA 3A73A 4OR0A 4FIPB 2BXMA 2E0XA 5BPKA 1J7EA 2EFHA 4FK5B 4F5VA 2LOQA 2DYOA 2XSIA 2V36A 2BXCA 4ZUXV 3NMUA 4DHXB 3KIKA 5GINA 2QHBA 2EFEA 4G03A 4N0UD 4M70B 4K2CA 2DBXA 3GA9L 3V09A 3FWBC 1HA2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZBQ A;  4LUF A;  3LU8 A;  1HK4 A;  1UOR A;  4Z69 A;  1E7A A;  2BXL A;  3JQZ A;  1BM0 A;  3LU6 A;  1TF0 A;  1BJ5 A;  2XW1 A;  3V08 A;  5IIU A;  5FUO A;  3B9L A;  1O9X A;  4IW2 A;  3UIV A;  5ID9 A;  2I2Z A;  1E7E A;  1N5U A;  2XVU A;  1E7C A;  3CX9 A;  1KXP D;  1HK1 A;  2BXG A;  2BXF A;  1GNI A;  2BXH A;  4F5U A;  1KW2 A;  4G04 A;  4HGM B;  2XVW A;  2BXN A;  4E99 A;  2BXO A;  5IJ5 A;  2BXA A;  1MA9 A;  2XVV A;  5IJF A;  5IIH A;  2BXB A;  5HOZ A;  2VUF A;  4LA0 A;  4LUH A;  1J78 A;  3TDL A;  2BXE A;  5IJE A;  4HGK A;  4IW1 A;  2VDB A;  2BXD A;  4S1Y A;  2XVQ A;  2XW0 A;  4PO0 A;  1BKE A;  4J2V A;  1E7G A;  1E7F A;  2VUE A;  1GNJ A;  5IIX A;  1E7I A;  3JRY A;  3V03 A;  4K71 A;  4ZBR A;  2YDF A;  4F5T A;  5DQF A;  4L9Q A;  1LOT A;  2BXP A;  3LU7 A;  4LB2 A;  4F5S A;  5ID7 A;  2BX8 A;  3B9M A;  5GHK A;  4EMX A;  2BXK A;  5IFO A;  4LB9 A;  1E78 A;  4N0F D;  2BXQ A;  1E7H A;  1HK2 A;  1HK5 A;  1AO6 A;  1H9Z A;  2BXI A;  2I30 A;  4L9K A;  4L8U A;  1HK3 A;  1E7B A;  4JK4 A;  3SQJ A;  4OT2 A;  5DBY A;  3A73 A;  4OR0 A;  2BXM A;  1J7E A;  4F5V A;  2XSI A;  2BXC A;  4G03 A;  4N0U D;  4K2C A;  3V09 A;  4BKE A;  1HA2 A; 
#chains in the Genus database with same CATH topology
 3ICX A;  4ZBQ A;  4WA6 B;  4LUF A;  3NVI A;  4GDX A;  2DYM A;  3LU8 A;  1HK4 A;  1UOR A;  2Z8I A;  4TQ1 A;  1E7A A;  2BXL A;  3FWC C;  4ZCG A;  3JQZ A;  4C31 B;  4Z69 A;  1BM0 A;  4Z9O A;  3LU6 A;  1TF0 A;  3SIU B;  5D7G A;  1BJ5 A;  2XW1 A;  4G01 A;  3V08 A;  4TQ0 A;  5IIU A;  4OTU A;  2ROH A;  2OZB B;  5FUO A;  3B9L A;  1O9X A;  4IW2 A;  1MUH A;  3UIV A;  5ID9 A;  2I2Z A;  1LNS A;  1E7E A;  1N5U A;  2XVU A;  1E7C A;  2CKX A;  3CX9 A;  1H5W A;  2EFD A;  1KXP D;  2XMO A;  4BKE A;  3VQI A;  1HK1 A;  2LXT A;  2BXG A;  1IJG A;  2BXF A;  2Z8J A;  4FJC B;  4GDL B;  3W1S A;  1GNI A;  1KDX A;  2BXH A;  2EFC A;  4F5U A;  1KW2 A;  4G04 A;  4HGM B;  4OTT A;  2XVW A;  4ZC6 A;  3ECP A;  2BXN A;  4E99 A;  3MHH B;  2BXO A;  2GUT A;  3KJL A;  5IJ5 A;  2BXA A;  1MA9 A;  5GIO A;  2XVV A;  5IJF A;  5IIH A;  2NQO A;  4BY9 C;  2BXB A;  2DBW A;  5HOZ A;  2DBU A;  2VUF A;  4LA0 A;  4LUH A;  4NAW B;  1J78 A;  3TDL A;  2LQH A;  2BXE A;  5IJE A;  4HGK A;  1TXU A;  3FNM A;  2LQI A;  3H37 A;  1VFI A;  3H3A A;  1FOU A;  3BPJ A;  4IW1 A;  3WHQ A;  2BXD A;  2VDB A;  4S1Y A;  3WHS A;  2XVQ A;  2XW0 A;  4PO0 A;  2AJE A;  1BKE A;  4J2V A;  1E7G A;  1E7F A;  2VUE A;  3G9K D;  3M99 C;  5B5T A;  2QMC A;  1GNJ A;  5IIX A;  3A75 A;  4W4U B;  1JNB A;  4MBE C;  2AGH B;  1E7I A;  3JRY A;  3V03 A;  4N3Z A;  2Z8K A;  4K71 A;  4ZBR A;  2YDF A;  4F5T A;  2KWF A;  5DQF A;  4L9Q A;  1MM8 A;  1LOT A;  2BXP A;  3LU7 A;  4LB2 A;  4F5S A;  5ID7 A;  2BX8 A;  3B9M A;  5GHK A;  4EMX A;  2BXK A;  2QM6 A;  4I9O A;  4ZBK A;  4LB9 A;  5IFO A;  1E78 A;  3SIV B;  1MUS A;  1NT2 B;  3GQX A;  4N0F D;  2BXQ A;  1MIW A;  1E7H A;  3PLA A;  2E0Y A;  3NVM A;  1HK2 A;  1HK5 A;  3GQU A;  1AO6 A;  1H9Z A;  2LXS A;  2BXI A;  2I30 A;  1MIY A;  4L9K A;  4DM0 A;  4L8U A;  1HK3 A;  1E7B A;  4GDK B;  3WHR A;  2KBZ A;  2DG5 A;  1SB0 A;  4D7X A;  2JUH A;  3NVK A;  4JK4 A;  3SQJ A;  2K0N A;  3MHS B;  4OT2 A;  4GG2 A;  5DBY A;  1VZS A;  2NNW A;  5GIP A;  2OT3 A;  1MIV A;  3A73 A;  4OR0 A;  4FIP B;  2BXM A;  2E0X A;  5BPK A;  1J7E A;  2EFH A;  4FK5 B;  4F5V A;  2LOQ A;  2DYO A;  2XSI A;  2V36 A;  2BXC A;  4ZUX V;  3NMU A;  4DHX B;  3KIK A;  5GIN A;  2QHB A;  2EFE A;  4G03 A;  4N0U D;  4M70 B;  4K2C A;  2DBX A;  3GA9 L;  3V09 A;  3FWB C;  1HA2 A; 
#chains in the Genus database with same CATH homology
 3ICX A;  4ZBQ A;  4WA6 B;  4LUF A;  3NVI A;  4GDX A;  2DYM A;  3LU8 A;  1HK4 A;  1UOR A;  2Z8I A;  4TQ1 A;  1E7A A;  2BXL A;  3FWC C;  4ZCG A;  3JQZ A;  4C31 B;  4Z69 A;  1BM0 A;  4Z9O A;  3LU6 A;  1TF0 A;  3SIU B;  5D7G A;  1BJ5 A;  2XW1 A;  4G01 A;  3V08 A;  4TQ0 A;  5IIU A;  4OTU A;  2ROH A;  2OZB B;  5FUO A;  3B9L A;  1O9X A;  4IW2 A;  3UIV A;  5ID9 A;  2I2Z A;  1LNS A;  1E7E A;  1N5U A;  2XVU A;  1E7C A;  2CKX A;  3CX9 A;  1H5W A;  2EFD A;  1KXP D;  2XMO A;  4BKE A;  3VQI A;  1HK1 A;  4FJC B;  2BXG A;  1IJG A;  2BXF A;  2Z8J A;  3W1S A;  4GDL B;  1GNI A;  2BXH A;  2EFC A;  4F5U A;  1KW2 A;  4G04 A;  4HGM B;  4OTT A;  2XVW A;  4ZC6 A;  2BXN A;  4E99 A;  3MHH B;  2BXO A;  3KJL A;  5IJ5 A;  2BXA A;  1MA9 A;  5GIO A;  2XVV A;  5IJF A;  5IIH A;  2NQO A;  2BXB A;  2DBW A;  5HOZ A;  2DBU A;  2VUF A;  4LA0 A;  4LUH A;  4NAW B;  1J78 A;  3TDL A;  2BXE A;  5IJE A;  4HGK A;  1TXU A;  3FNM A;  3H37 A;  3H3A A;  1VFI A;  4BY9 C;  1FOU A;  4IW1 A;  3WHQ A;  2BXD A;  2VDB A;  4S1Y A;  3WHS A;  2XVQ A;  2XW0 A;  4PO0 A;  2AJE A;  1BKE A;  4J2V A;  1E7G A;  1E7F A;  2VUE A;  3G9K D;  3M99 C;  5B5T A;  2QMC A;  1GNJ A;  5IIX A;  3A75 A;  4W4U B;  1JNB A;  4MBE C;  1E7I A;  3JRY A;  3V03 A;  4N3Z A;  2Z8K A;  4K71 A;  4ZBR A;  2YDF A;  4F5T A;  5DQF A;  4L9Q A;  1LOT A;  2BXP A;  3LU7 A;  4LB2 A;  4F5S A;  5ID7 A;  2BX8 A;  3B9M A;  5GHK A;  4EMX A;  2BXK A;  2QM6 A;  4ZBK A;  5IFO A;  4LB9 A;  1E78 A;  3SIV B;  1NT2 B;  3GQX A;  4N0F D;  2BXQ A;  1MIW A;  1E7H A;  3PLA A;  2E0Y A;  3NVM A;  1HK2 A;  1HK5 A;  3GQU A;  1AO6 A;  1H9Z A;  2BXI A;  2I30 A;  1MIY A;  4L9K A;  4L8U A;  1HK3 A;  1E7B A;  4GDK B;  3WHR A;  2KBZ A;  2DG5 A;  2JUH A;  3NVK A;  4JK4 A;  3SQJ A;  3MHS B;  4OT2 A;  4GG2 A;  5DBY A;  1VZS A;  2NNW A;  5GIP A;  2OT3 A;  1MIV A;  3A73 A;  4OR0 A;  4FIP B;  2BXM A;  2E0X A;  5BPK A;  1J7E A;  2EFH A;  4FK5 B;  4F5V A;  2LOQ A;  2DYO A;  2XSI A;  2V36 A;  2BXC A;  4ZUX V;  3NMU A;  4DHX B;  3KIK A;  5GIN A;  2QHB A;  2EFE A;  4G03 A;  4N0U D;  4M70 B;  4K2C A;  2DBX A;  3GA9 L;  3V09 A;  3FWB C;  1HA2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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