1HK5A

Human serum albumin mutant r218h complexed with thyroxine (3,3',5,5'-tetraiodo-l-thyronine) and myristic acid (tetradecanoic acid)
Total Genus 218
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
218
sequence length
582
structure length
582
Chain Sequence
HKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVAHLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords SERUM ALBUMIN
publication title Structural Basis of Albumin-Thyroxine Interactions and Familial Dysalbuminemic Hyperthyroxinemia
pubmed doi rcsb
source organism Homo sapiens
molecule tags Plasma protein
total genus 218
structure length 582
sequence length 582
ec nomenclature
pdb deposition date 2003-03-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk5A03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk5A02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk5A04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk5A01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk5A06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk5A05
3LU6A 2BXOA 1E78A 4JK4A 2BXQA 4F5UA 2BXKA 3JRYA 2BXGA 3UIVA 4F5VA 4BKEA 3A73A 2I30A 1E7BA 3SQJA 4PO0A 3LU8A 5IIXA 2I2ZA 4G03A 1HK2A 4IW2A 5HOZA 1O9XA 5GHKA 2BXDA 3B9LA 2VUFA 2BXNA 3CX9A 2XVWA 4LB2A 5IJEA 4HGKA 1HK1A 4ZBRA 4L8UA 2BXHA 4L9QA 2XW1A 5ID9A 3V03A 1J7EA 5DBYA 5ID7A 2BXBA 4OT2A 4IW1A 4K71A 1LOTA 4F5TA 4Z69A 1E7HA 2BXFA 4K2CA 1AO6A 2BXMA 1KXPD 2XVQA 4G04A 5IJFA 2BX8A 4S1YA 3LU7A 4LUFA 4LB9A 1HA2A 1KW2A 2BXLA 1MA9A 2BXEA 1BKEA 3V08A 1HK3A 4HGMB 1UORA 4ZBQA 1E7FA 1E7IA 4LUHA 1BJ5A 3JQZA 4EMXA 4L9KA 3V09A 1J78A 2XVUA 5DQFA 2XSIA 3B9MA 4F5SA 1TF0A 2VUEA 1E7EA 2XVVA 4OR0A 4N0UD 1N5UA 1E7GA 1H9ZA 1GNIA 3TDLA 5IFOA 1BM0A 1GNJA 1HK5A 2BXPA 2BXCA 2BXAA 5FUOA 4E99A 4J2VA 4LA0A 2VDBA 2YDFA 1E7CA 1E7AA 2XW0A 4N0FD 1HK4A 5IIUA 5IJ5A 2BXIA 5IIHA
chains in the Genus database with same CATH superfamily
3H3AA 2LOQA 1VZSA 3LU6A 3BPJA 2BXOA 2DYOA 4I9OA 1E78A 4JK4A 3NVKA 2BXQA 2AGHB 3GQXA 4F5UA 2BXKA 3JRYA 1MIVA 2BXGA 4ZCGA 3UIVA 3PLAA 1SB0A 3VQIA 4F5VA 3ECPA 4BKEA 1FOUA 2I30A 1E7BA 3A73A 3SQJA 4PO0A 3LU8A 5IIXA 2I2ZA 4G03A 3G9KD 3NVMA 4C31B 1HK2A 4IW2A 2E0XA 2Z8JA 4ZUXV 5HOZA 1O9XA 1MIWA 5GHKA 2BXDA 3B9LA 2EFHA 2XMOA 2VUFA 2BXNA 4GDXA 3CX9A 4D7XA 2K0NA 2LQIA 2XVWA 4LB2A 5IJEA 3GQUA 4HGKA 1HK1A 3ICXA 4ZBRA 4L8UA 4BY9C 2BXHA 4L9QA 2XW1A 2EFCA 5ID9A 4FJCB 3V03A 1J7EA 5DBYA 1JNBA 4M70B 2QMCA 4ZBKA 5GINA 2DBXA 3KJLA 5ID7A 4G01A 2BXBA 4OT2A 4DM0A 4IW1A 4K71A 3MHHB 1H5WA 1LOTA 2QHBA 3NMUA 4F5TA 3SIVB 4Z69A 1E7HA 2BXFA 4W4UB 1MUSA 4K2CA 1AO6A 2GUTA 4GDKB 2KWFA 4GG2A 2OZBB 2BXMA 2JUHA 2NNWA 1KXPD 2XVQA 4G04A 5IJFA 2CKXA 3FWBC 2BX8A 3KIKA 4S1YA 3WHRA 2Z8IA 3LU7A 4LB9A 4LUFA 1HA2A 4Z9OA 2EFDA 1KW2A 2BXLA 1MA9A 2BXEA 1BKEA 3V08A 1HK3A 4HGMB 1UORA 4ZBQA 1E7FA 1E7IA 4LUHA 1BJ5A 1LNSA 1VFIA 3JQZA 1IJGA 4EMXA 2LXTA 4L9KA 4GDLB 3W1SA 5B5TA 3MHSB 3V09A 1J78A 2XVUA 5DQFA 3WHSA 4OTTA 5GIOA 3A75A 2NQOA 2XSIA 2ROHA 3SIUB 1MM8A 4NAWB 5GIPA 3B9MA 3M99C 3H37A 4F5SA 1TF0A 2EFEA 4OTUA 2QM6A 4MBEC 2OT3A 2VUEA 4ZC6A 5BPKA 1E7EA 2XVVA 4OR0A 4N0UD 2DG5A 4FIPB 1N5UA 2DBUA 3WHQA 2LXSA 4WA6B 2Z8KA 3NVIA 1E7GA 1H9ZA 1GNIA 2E0YA 2AJEA 1MIYA 5IFOA 1BM0A 1GNJA 3TDLA 1KDXA 1HK5A 2BXPA 3FWCC 2BXCA 2BXAA 2V36A 4FK5B 5FUOA 4TQ0A 5D7GA 1NT2B 2DBWA 2LQHA 4E99A 4J2VA 2DYMA 4LA0A 2VDBA 2YDFA 1E7CA 1E7AA 2XW0A 4N3ZA 3FNMA 4N0FD 1HK4A 3GA9L 1MUHA 5IIUA 1TXUA 2KBZA 5IJ5A 2BXIA 5IIHA 4DHXB 4TQ1A
chains in the Genus database with same CATH topology
3H3AA 2LOQA 1VZSA 3LU6A 2BXOA 2DYOA 1E78A 4JK4A 3NVKA 2BXQA 3GQXA 4F5UA 2BXKA 3JRYA 1MIVA 2BXGA 4ZCGA 3UIVA 3PLAA 3VQIA 4F5VA 4BKEA 1FOUA 2I30A 1E7BA 3A73A 3SQJA 4PO0A 3LU8A 5IIXA 2I2ZA 4G03A 3G9KD 3NVMA 4C31B 1HK2A 4IW2A 2E0XA 2Z8JA 4ZUXV 5HOZA 1O9XA 1MIWA 5GHKA 2BXDA 3B9LA 2EFHA 2XMOA 2VUFA 2BXNA 4GDXA 3CX9A 2XVWA 4LB2A 5IJEA 3GQUA 4HGKA 1HK1A 3ICXA 4ZBRA 4L8UA 4BY9C 2BXHA 4L9QA 2XW1A 2EFCA 5ID9A 4FJCB 3V03A 1J7EA 5DBYA 1JNBA 4M70B 2QMCA 4ZBKA 5GINA 2DBXA 3KJLA 5ID7A 4G01A 2BXBA 4OT2A 4IW1A 4K71A 3MHHB 1H5WA 1LOTA 2QHBA 3NMUA 4F5TA 3SIVB 4Z69A 1E7HA 2BXFA 4W4UB 4K2CA 1AO6A 4GDKB 4GG2A 2OZBB 2BXMA 2JUHA 2NNWA 1KXPD 2XVQA 4G04A 5IJFA 2CKXA 3FWBC 2BX8A 3KIKA 4S1YA 3WHRA 2Z8IA 3LU7A 4LB9A 4LUFA 1HA2A 4Z9OA 2EFDA 1KW2A 2BXLA 1MA9A 2BXEA 1BKEA 3V08A 1HK3A 4HGMB 1UORA 4ZBQA 1E7FA 1E7IA 4LUHA 1BJ5A 1LNSA 1VFIA 3JQZA 1IJGA 4EMXA 4L9KA 3W1SA 4GDLB 5B5TA 3MHSB 3V09A 1J78A 2XVUA 5DQFA 3WHSA 4OTTA 5GIOA 3A75A 2NQOA 2XSIA 2ROHA 3SIUB 4NAWB 5GIPA 3B9MA 3M99C 3H37A 4F5SA 1TF0A 2EFEA 4OTUA 2QM6A 4MBEC 2OT3A 2VUEA 4ZC6A 5BPKA 1E7EA 2XVVA 4OR0A 4N0UD 2DG5A 4FIPB 1N5UA 2DBUA 3WHQA 4WA6B 2Z8KA 3NVIA 1E7GA 1H9ZA 1GNIA 2E0YA 2AJEA 1MIYA 5IFOA 1BM0A 1GNJA 3TDLA 1HK5A 2BXPA 3FWCC 2BXCA 2BXAA 2V36A 4FK5B 5FUOA 4TQ0A 5D7GA 1NT2B 2DBWA 4E99A 4J2VA 2DYMA 4LA0A 2VDBA 2YDFA 1E7CA 1E7AA 2XW0A 4N3ZA 3FNMA 4N0FD 1HK4A 3GA9L 5IIUA 1TXUA 2KBZA 5IJ5A 2BXIA 5IIHA 4DHXB 4TQ1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LU6 A;  2BXO A;  1E78 A;  4JK4 A;  2BXQ A;  4F5U A;  2BXK A;  3JRY A;  2BXG A;  3UIV A;  4F5V A;  4BKE A;  3A73 A;  2I30 A;  1E7B A;  3SQJ A;  4PO0 A;  3LU8 A;  5IIX A;  2I2Z A;  4G03 A;  1HK2 A;  4IW2 A;  5HOZ A;  1O9X A;  5GHK A;  2BXD A;  3B9L A;  2VUF A;  2BXN A;  3CX9 A;  2XVW A;  4LB2 A;  5IJE A;  4HGK A;  1HK1 A;  4ZBR A;  4L8U A;  2BXH A;  4L9Q A;  2XW1 A;  5ID9 A;  3V03 A;  1J7E A;  5DBY A;  5ID7 A;  2BXB A;  4OT2 A;  4IW1 A;  4K71 A;  1LOT A;  4F5T A;  4Z69 A;  1E7H A;  2BXF A;  4K2C A;  1AO6 A;  2BXM A;  1KXP D;  2XVQ A;  4G04 A;  5IJF A;  2BX8 A;  4S1Y A;  3LU7 A;  4LUF A;  4LB9 A;  1HA2 A;  1KW2 A;  2BXL A;  1MA9 A;  2BXE A;  1BKE A;  3V08 A;  1HK3 A;  4HGM B;  1UOR A;  4ZBQ A;  1E7F A;  1E7I A;  4LUH A;  1BJ5 A;  3JQZ A;  4EMX A;  4L9K A;  3V09 A;  1J78 A;  2XVU A;  5DQF A;  2XSI A;  3B9M A;  4F5S A;  1TF0 A;  2VUE A;  1E7E A;  2XVV A;  4OR0 A;  4N0U D;  1N5U A;  1E7G A;  1H9Z A;  1GNI A;  3TDL A;  5IFO A;  1BM0 A;  1GNJ A;  1HK5 A;  2BXP A;  2BXC A;  2BXA A;  5FUO A;  4E99 A;  4J2V A;  4LA0 A;  2VDB A;  2YDF A;  1E7C A;  1E7A A;  2XW0 A;  4N0F D;  1HK4 A;  5IIU A;  5IJ5 A;  2BXI A;  5IIH A; 
#chains in the Genus database with same CATH topology
 3H3A A;  2LOQ A;  1VZS A;  3LU6 A;  3BPJ A;  2BXO A;  2DYO A;  4I9O A;  1E78 A;  4JK4 A;  3NVK A;  2BXQ A;  2AGH B;  3GQX A;  4F5U A;  2BXK A;  3JRY A;  1MIV A;  2BXG A;  4ZCG A;  3UIV A;  3PLA A;  1SB0 A;  3VQI A;  4F5V A;  3ECP A;  4BKE A;  1FOU A;  2I30 A;  1E7B A;  3A73 A;  3SQJ A;  4PO0 A;  3LU8 A;  5IIX A;  2I2Z A;  4G03 A;  3G9K D;  3NVM A;  4C31 B;  1HK2 A;  4IW2 A;  2E0X A;  2Z8J A;  4ZUX V;  5HOZ A;  1O9X A;  1MIW A;  5GHK A;  2BXD A;  3B9L A;  2EFH A;  2XMO A;  2VUF A;  2BXN A;  4GDX A;  3CX9 A;  4D7X A;  2K0N A;  2LQI A;  2XVW A;  4LB2 A;  5IJE A;  3GQU A;  4HGK A;  1HK1 A;  3ICX A;  4ZBR A;  4L8U A;  4BY9 C;  2BXH A;  4L9Q A;  2XW1 A;  2EFC A;  5ID9 A;  4FJC B;  3V03 A;  1J7E A;  5DBY A;  1JNB A;  4M70 B;  2QMC A;  4ZBK A;  5GIN A;  2DBX A;  3KJL A;  5ID7 A;  4G01 A;  2BXB A;  4OT2 A;  4DM0 A;  4IW1 A;  4K71 A;  3MHH B;  1H5W A;  1LOT A;  2QHB A;  3NMU A;  4F5T A;  3SIV B;  4Z69 A;  1E7H A;  2BXF A;  4W4U B;  1MUS A;  4K2C A;  1AO6 A;  2GUT A;  4GDK B;  2KWF A;  4GG2 A;  2OZB B;  2BXM A;  2JUH A;  2NNW A;  1KXP D;  2XVQ A;  4G04 A;  5IJF A;  2CKX A;  3FWB C;  2BX8 A;  3KIK A;  4S1Y A;  3WHR A;  2Z8I A;  3LU7 A;  4LB9 A;  4LUF A;  1HA2 A;  4Z9O A;  2EFD A;  1KW2 A;  2BXL A;  1MA9 A;  2BXE A;  1BKE A;  3V08 A;  1HK3 A;  4HGM B;  1UOR A;  4ZBQ A;  1E7F A;  1E7I A;  4LUH A;  1BJ5 A;  1LNS A;  1VFI A;  3JQZ A;  1IJG A;  4EMX A;  2LXT A;  4L9K A;  4GDL B;  3W1S A;  5B5T A;  3MHS B;  3V09 A;  1J78 A;  2XVU A;  5DQF A;  3WHS A;  4OTT A;  5GIO A;  3A75 A;  2NQO A;  2XSI A;  2ROH A;  3SIU B;  1MM8 A;  4NAW B;  5GIP A;  3B9M A;  3M99 C;  3H37 A;  4F5S A;  1TF0 A;  2EFE A;  4OTU A;  2QM6 A;  4MBE C;  2OT3 A;  2VUE A;  4ZC6 A;  5BPK A;  1E7E A;  2XVV A;  4OR0 A;  4N0U D;  2DG5 A;  4FIP B;  1N5U A;  2DBU A;  3WHQ A;  2LXS A;  4WA6 B;  2Z8K A;  3NVI A;  1E7G A;  1H9Z A;  1GNI A;  2E0Y A;  2AJE A;  1MIY A;  5IFO A;  1BM0 A;  1GNJ A;  3TDL A;  1KDX A;  1HK5 A;  2BXP A;  3FWC C;  2BXC A;  2BXA A;  2V36 A;  4FK5 B;  5FUO A;  4TQ0 A;  5D7G A;  1NT2 B;  2DBW A;  2LQH A;  4E99 A;  4J2V A;  2DYM A;  4LA0 A;  2VDB A;  2YDF A;  1E7C A;  1E7A A;  2XW0 A;  4N3Z A;  3FNM A;  4N0F D;  1HK4 A;  3GA9 L;  1MUH A;  5IIU A;  1TXU A;  2KBZ A;  5IJ5 A;  2BXI A;  5IIH A;  4DHX B;  4TQ1 A; 
#chains in the Genus database with same CATH homology
 3H3A A;  2LOQ A;  1VZS A;  3LU6 A;  2BXO A;  2DYO A;  1E78 A;  4JK4 A;  3NVK A;  2BXQ A;  3GQX A;  4F5U A;  2BXK A;  3JRY A;  1MIV A;  2BXG A;  4ZCG A;  3UIV A;  3PLA A;  3VQI A;  4F5V A;  4BKE A;  1FOU A;  2I30 A;  1E7B A;  3A73 A;  3SQJ A;  4PO0 A;  3LU8 A;  5IIX A;  2I2Z A;  4G03 A;  3G9K D;  3NVM A;  4C31 B;  1HK2 A;  4IW2 A;  2E0X A;  2Z8J A;  4ZUX V;  5HOZ A;  1O9X A;  1MIW A;  5GHK A;  2BXD A;  3B9L A;  2EFH A;  2XMO A;  2VUF A;  2BXN A;  4GDX A;  3CX9 A;  2XVW A;  4LB2 A;  5IJE A;  3GQU A;  4HGK A;  1HK1 A;  3ICX A;  4ZBR A;  4L8U A;  4BY9 C;  2BXH A;  4L9Q A;  2XW1 A;  2EFC A;  5ID9 A;  4FJC B;  3V03 A;  1J7E A;  5DBY A;  1JNB A;  4M70 B;  2QMC A;  4ZBK A;  5GIN A;  2DBX A;  3KJL A;  5ID7 A;  4G01 A;  2BXB A;  4OT2 A;  4IW1 A;  4K71 A;  3MHH B;  1H5W A;  1LOT A;  2QHB A;  3NMU A;  4F5T A;  3SIV B;  4Z69 A;  1E7H A;  2BXF A;  4W4U B;  4K2C A;  1AO6 A;  4GDK B;  4GG2 A;  2OZB B;  2BXM A;  2JUH A;  2NNW A;  1KXP D;  2XVQ A;  4G04 A;  5IJF A;  2CKX A;  3FWB C;  2BX8 A;  3KIK A;  4S1Y A;  3WHR A;  2Z8I A;  3LU7 A;  4LB9 A;  4LUF A;  1HA2 A;  4Z9O A;  2EFD A;  1KW2 A;  2BXL A;  1MA9 A;  2BXE A;  1BKE A;  3V08 A;  1HK3 A;  4HGM B;  1UOR A;  4ZBQ A;  1E7F A;  1E7I A;  4LUH A;  1BJ5 A;  1LNS A;  1VFI A;  3JQZ A;  1IJG A;  4EMX A;  4L9K A;  3W1S A;  4GDL B;  5B5T A;  3MHS B;  3V09 A;  1J78 A;  2XVU A;  5DQF A;  3WHS A;  4OTT A;  5GIO A;  3A75 A;  2NQO A;  2XSI A;  2ROH A;  3SIU B;  4NAW B;  5GIP A;  3B9M A;  3M99 C;  3H37 A;  4F5S A;  1TF0 A;  2EFE A;  4OTU A;  2QM6 A;  4MBE C;  2OT3 A;  2VUE A;  4ZC6 A;  5BPK A;  1E7E A;  2XVV A;  4OR0 A;  4N0U D;  2DG5 A;  4FIP B;  1N5U A;  2DBU A;  3WHQ A;  4WA6 B;  2Z8K A;  3NVI A;  1E7G A;  1H9Z A;  1GNI A;  2E0Y A;  2AJE A;  1MIY A;  5IFO A;  1BM0 A;  1GNJ A;  3TDL A;  1HK5 A;  2BXP A;  3FWC C;  2BXC A;  2BXA A;  2V36 A;  4FK5 B;  5FUO A;  4TQ0 A;  5D7G A;  1NT2 B;  2DBW A;  4E99 A;  4J2V A;  2DYM A;  4LA0 A;  2VDB A;  2YDF A;  1E7C A;  1E7A A;  2XW0 A;  4N3Z A;  3FNM A;  4N0F D;  1HK4 A;  3GA9 L;  5IIU A;  1TXU A;  2KBZ A;  5IJ5 A;  2BXI A;  5IIH A;  4DHX B;  4TQ1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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