1HM2A

Active site of chondroitinase ac lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis
Total Genus 239
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
239
sequence length
674
structure length
674
Chain Sequence
GTAELIMKRVMLDLKKPLRNMDKVAEKNLNTLQPDGSWKDVPYKDDAMTNWLPNNHLLQLETIIQAYIEKDSHYYGDDKVFDQISKAFKYWYDSDPKSRNWWHNEIATPQALGEMLILMRYGKKPLDEALVHKLTERMKRGEPEKKTGANKTDIALHYFYRALLTSDEALLSFAVKELFYPVQFVHYEEGLQYDYSYLQHGPQLQISSYGAVFITGVLKLANYVRDTPYALSTEKLAIFSKYYRDSYLKAIRGSYMDFNVEGRGVSRPDILNKKAEKKRLLVAKMIDLKHTEEWADAIARTDSTVAAGYKIEPYHHQFWNGDYVQHLRPAYSFNVRMVSKRTRRSESGNKENLLGRYLSDGATNIQLRGPEYYNIMPVWEWDKIPGITSRDYLTDRPLTKLWGEQGSNDFAGGVSDGVYGASAYALDYDSLQAKKAWFFFDKEIVCLGAGINSNAPENITTTLNQSWLNGPVISTAGKTGRGKITTFKAQGQFWLLHDAIGYYFPEGANLSLSTQSQKGNWFHINNSHSKDEVSGDVFKLWINHGARPENAQYAYIVLPGINKPEEIKKYNGTAPKVLANTNQLQAVYHQQLDMVQAIFYTAGKLSVAGIEIETDKPCAVLIKHINGKQVIWAADPLQKEKTAVLSIRDLKTGKTNRVKIDFPQQEFAGATVEL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis.
pubmed doi rcsb
source organism Pedobacter heparinus
molecule tags Lyase
molecule keywords CHONDROITINASE AC
total genus 239
structure length 674
sequence length 674
ec nomenclature ec 4.2.2.5: Chondroitin AC lyase.
pdb deposition date 2000-12-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02278 Lyase_8 Polysaccharide lyase family 8, super-sandwich domain
A PF02884 Lyase_8_C Polysaccharide lyase family 8, C-terminal beta-sandwich domain
A PF08124 Lyase_8_N Polysaccharide lyase family 8, N terminal alpha-helical domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.50.10.100 Mainly Alpha Alpha/alpha barrel Glycosyltransferase Chondroitin AC/alginate lyase 1hm2A01
2.60.220.10 Mainly Beta Sandwich Chondroitinase Ac; Chain A, domain 3 Polysaccharide lyase family 8-like, C-terminal 1hm2A03
2.70.98.10 Mainly Beta Distorted Sandwich Beta-galactosidase; Chain A, domain 5 Beta-galactosidase; Chain A, domain 5 1hm2A02
1HM3A 1HN1A 3T2OA 3J7HA 3T0DA 1JZ5A 2JKPA 3VD4A 1NSUA 2FUQA 1Z45A 1N7PA 2WVXA 2CIRA 1LOHA 5JMFA 1JZ4A 3DECA 1MMUA 1K1XA 1NS8A 3E1F1 1DP0A 1NSXA 4MMIA 2HTAA 2BRPA 2HTBA 1X1HA 1K1WA 2WCOA 4DUXA 3AFLA 4D6JA 5JMDA 1TXKA 1N7RA 1NSVA 1YGAA 1YQ2A 1JYVA 1JZ8A 2WW2A 2CIQA 2WW3A 2WMIB 3NREA 4DUVA 1F4HA 5E1QA 1I8QA 3IAPA 3NJXA 3MV01 3T2PA 3NNBA 1PX4A 2E22A 1CB8A 1QAZA 1RWAA 2D73A 3MUY1 3T09A 1RWFA 3T0AA 1K1YA 1NS0A 1JOVA 5A1AA 1NSZA 3ECQA 4D72A 2WMJA 3OS7A 1RW9A 1J0NA 2ZXQA 2FUTA 4OK2A 1F1SA 1JZ3A 1JZ7A 1JYWA 1LF9A 1PX3A 1RWGA 4BZEA 3BGAA 1JYNA 2X03A 2WVXB 3VD7A 4BZGA 1RWHA 3IMHA 2WVYA 3VDBA 3A24A 4NEIA 1HN0A 1MMYA 1NS4A 4AQ0A 1OJMA 4BZHA 4OZVA 1NSSA 1RWCA 1NS2A 3OB8A 1LURA 1NSMA 3IAQA 1HM2A 4OZWA 4D6GA 2BRVX 4D6EA 3DYMA 3T2QA 3VDAA 1JZ2A 3VSMA 4MMHA 3WFAA 3DCDA 2JKAA 1HMUA 2WDAA 2E24A 1HMWA 4D6IA 1N7NA 3SEPA 3K25A 2WZSA 4RNLA 1HV6A 3MV11 1N7OA 2XSGA 4BZFA 1L7KA 1LXKA 1F4AA 2BRWA 2WW0A 1W3YA 1NKGA 3I3DA 3I3BA 3MUZ1 3VDCA 1N7QA 3I3EA 1ULVA 4E1YA 1EGUA 1C82A 4F13A 3OBAA 3T0BA 2WMFA 1UG9A 2ZQ0A 1MMXA 3NFVA 3DYPA 3VD3A 3E7JA 1JZ6A 2WMKA 2WMGA 1SO0A 1LXMA 3E80A 2WMIA 1NS7A 1JYXA 1F9GA 1LF6A 1MMZA 2JKEA 2WW1A 4D6DA 4F10A 1OJPA 4D6HA 3MWXA 3VD5A 3VD9A 3T08A 1SNZA 4OJZA 2WVZA 3NJVA 1OJNA 1MN0A 2WMHA 1J0MA 1OJOA 3DYOA 1X1JA 2CISA 3A0OA 1L7JA 4D6CA 4DUWA 2XHNA 3VSNA 4OK4A 4FNVA 1X1IA 2Q1FA 3CZJA 4D71A 4TTGA 4D6FA 1NSRA 3Q1NA
chains in the Genus database with same CATH superfamily
2AFAA 3PMMA 3GLYA 1IQYA 1OACA 1KRFA 3EQAA 1N21A 4C1SA 4WVCA 4YDEB 1QBQB 4AYPA 3PQIA 2OW6A 2WOHA 3BUDA 1TF4A 3KLSA 4JJJA 1C3DA 1N24A 1N20A 2DRQA 3Q7FB 3E1F1 5AGDA 1NSXA 1WMOA 3M73A 1TU5A 3HXBB 4WVAA 3QT3A 2HTAA 2HTBA 3K5TA 4DI5A 2RI9A 4DUXA 1GLMA 3AFJA 1N94B 1V7VA 3HXDB 4AYOA 2WW2A 5E2JA 1AGMA 2WMIB 1DCEB 5IKAA 5E1QA 1I8QA 3W7XA 1W6KA 1TQVA 4K35A 3M7BA 5DGQA 1N4RB 3M78A 3MUY1 2XN1A 1RWFA 2EABA 1UI8A 3C72B 5EASA 1JOVA 1LD8B 1IA7A 1HWWA 3T33A 5ILHA 2WGQA 3ON6A 2KXSA 5M7YA 3DDFA 1TQTA 1O1TB 1PX3A 1JYNA 3CIHA 2ONHA 4XUVA 1O6HA 1KSCA 1MMYA 1NS4A 1CLCA 4EHMB 1OJMA 2CFDA 4OZVA 3G4FA 1NSMA 1TN6B 2VN7A 4CE7A 4D6EA 1G6IA 5IK0A 1HXGA 2CQSA 3DPYB 3M76A 4K3AA 3DCDA 1H13A 1HMUA 5ILDA 1FPPB 1QWUA 2XN0A 3X42A 2E24A 1HMWA 1GAIA 3EUVB 4D6IA 1WU4A 3H3KA 3WC3A 2WZSA 3N0GA 3RENA 4D4DA 3DX3A 3K25A 3MV11 2EACA 3HXCB 1GXOA 3WIQA 3M7EA 1N4PB 2BB5A 2EAEA 4D1IA 3ALAA 2FUZA 3BS6A 1NKGA 1AYXA 1O1RB 2WINB 4YCRA 1X81B 3G6JB 3M7LA 3VDCA 3OBAA 3K7XA 4E1YA 2JJBA 3BLBA 2EADA 2WMFA 1UG9A 2AHFA 2ZQ0A 3DYPA 3Q79B 3EU5B 2F0YB 4L6XA 1NC5A 3M74A 2R2LB 3KSLB 1TNBB 1JZ6A 1SA5B 1DL2A 1G87A 5JPNB 1SO0A 3BVXA 3DX0A 1HXAA 1F9GA 2CFWA 2AHGA 1WMNA 2WW1A 4EV2A 2F6DA 3WA2X 1W7CA 4D4AA 2D1WA 5ILKA 3A3VA 2H6HB 2BB6A 3NBJA 3MWXA 1H35A 3SDUA 1JS4A 3WIRA 1H14A 3SDQA 1HXKA 4FNUA 1AV4A 1N1ZA 4J5TA 3WKGA 1G9GA 1UMPA 1J0MA 1OJOA 1R76A 4D4CA 5IM1A 2F7OA 1L7JA 4D6CA 1R33A 1H3AA 5IKHA 4FNRA 4DUWA 1X1IA 2A8ZA 4BOJA 1NL4B 1TNOB 3Q1NA 1HM3A 4LIXA 3DX2A 4GTTB 1IVUA 1HN1A 3J7HA 3HIGA 1R34A 1JCSB 3DX1A 3KBUC 1GAHA 1L2AA 2ONGA 2GH4A 2V3PA 3VD4A 3HXEB 3VXDA 2Y74A 2DRRA 1GXNA 2CIRA 3QR8A 5JMFA 1JZ4A 3E6UA 3AMOB 3DECA 1MMUA 1K1XA 1DP0A 3QFYA 4MMIA 1D6YA 1FT1B 4D1JA 4CJ1A 2A73B 3EJQA 1H3CA 3M75A 1TXKA 4FNQA 2WYHA 3DSXB 3LOYA 2G02A 1JYVA 2V8JA 3DSVB 2RGKA 3PZ1B 3MI6A 3PZ3B 3W5MA 4ONTA 2FYVA 4DODA 3NREA 1PU4A 1N95B 1QX1A 5CD2A 4AYQA 4BOKA 3T2PA 3NNBA 3X3XA 4BTWA 1PX4A 3D4ZA 2CG1A 4GTSB 2DRSA 1KSDA 1QSJA 1RWAA 2D73A 1NS0A 3W5NA 1G9JA 1N9EA 2DROA 2WMJA 4BTYA 1RW9A 1N22A 2FUTA 4MBGB 4OK2A 3SDVA 2VN4A 3ANIA 1JYWA 4D4BA 3BGAA 3G4DA 2X03A 2WVXB 3VD7A 5C05A 3DSTB 3IMHA 3VDBA 1AVLA 2CFKA 4KTRA 3A24A 1W6GA 3P5RA 5IL3A 1EKMA 1NS2A 1RWCA 3NBBA 1LURA 1HM2A 2WYIA 2ZBLA 1L1YA 3E37B 3ANJA 4OZWA 5GZKA 4D6GA 2YX9A 1N1BA 3KBTC 1N23A 1F9DA 1KZOB 2IEJB 4V1RA 4MMHA 2E2TA 3BVUA 2E2UA 1FO2A 4FUSA 1K72A 4KFFA 1W4NA 4Z4LA 4BZFA 1L7KA 2OKXA 3PGBA 1LXKA 3BVTA 3EJSA 1JCQB 2WW0A 2YFNA 1QALA 1WU6A 3I3DA 4FNTA 4FXKB 1N7QA 2OQEC 3WVFA 1ULVA 3QSPA 3HIIA 1WZZA 3H7LA 3T0BA 3S4CA 3HI7A 4KKIA 2PNCA 2Y73A 2CG0A 3NFVA 3X17A 1V5DA 5KKBA 3E7JA 4ZRQA 2D8LA 3P5PA 2CWVA 3QWTA 1V7XA 4TXTA 1O7DD 3QG0A 5IL8A 1FMIA 1N4SB 1LF6A 1MMZA 1H12A 3WKFA 2OOVC 4L9PB 1KFGA 2CWUA 2OOVA 1W2ZA 3EJPA 3T08A 1SIHA 4CJ0A 3M02A 1IVXA 3QT9A 1MN0A 2WY8A 2G0DA 3A0OA 2GOXA 3VSNA 4OK4A 2Q1FA 5IK6A 3P2CA 3D5SA 4D71A 3M71A 3UD1A 1W5ZA 1FP3A 1O6QA 4ZH1A 3U7VA 2CFLA 4UFCA 1JZ5A 4DLOA 3BUPA 2ALWA 1NSUA 2FUQA 4Q2BA 1N7PA 3E73A 5DGRA 3RX5A 4WU0A 1WMPA 1MZCB 2V3NA 1NS8A 2V8KA 3QXFA 2F7RA 1WU5A 1N4QB 2C11A 3RJ3A 1TN8B 3AFLA 3EU8A 5JMDA 5FO7B 1FBOA 1NSVA 4KFEA 1YGAA 1TNYB 1YQ2A 3X41A 3OXUA 1JZ8A 2B4FA 2WW3A 3LZ9A 1XWTA 4FNPA 4DUVA 2ZL8A 1FT2B 3NJXA 3IAPA 3M72A 3MV01 2CQTA 5CZLA 2FV1A 5EAUA 3TF4A 1F9OA 1KS8A 5ILJA 1FO3A 3OEDA 2E22A 1CB8A 3M01A 3CZNA 3QFZA 3T0AA 2PN5A 3RSYA 3HXFB 1NSZA 3ECQA 2WIIB 3DSUB 3GT5A 4MU9A 1D8EB 4D72A 3OS7A 1FAEA 1J0NA 1X9DA 3E30B 2ZXQA 2RI8A 1HX9A 4Q88A 1F1SA 1JZ3A 1LF9A 1RWGA 3DRAB 4BZEA 3N0FA 5GY3A 4BZGA 1HN0A 1JCRB 1QAKA 4AQ0A 3BUQA 1RQ5A 1NSSA 3OB8A 3WKIA 4TF4A 1GHQA 3BVVA 3T0UA 1IU7A 1NXCA 2OQEA 3N9HA 1RKYA 3DSSB 3PZ4B 2BRVX 3DYMA 2E2VA 3T2QA 3VDAA 2BEDB 3VSMA 2Z07A 1H3BA 2XQWA 3RX7A 1IA6A 3M7CA 3M77A 4FXGB 1HV6A 3CV5A 5ILZA 1N7OA 2YIKA 2XWJB 1KZPB 4LNVA 2XSGA 1DOGA 4GL3A 2H6GB 3CU7A 2WY7A 1KKTA 1XWQA 4ZG8A 4GAXA 3D4YA 1TN7B 3X40A 3I3EA 3S4AA 1CEMA 2ZISB 1GXMA 1TQUA 1QQFA 2F7QA 4DOEA 2FBAA 5DHIA 1HTYA 3WA3A 1MMXA 5ILYA 3DSWB 3VD3A 4EL8A 5FOBB 3GZKA 2WMKA 3CZSA 3DX4A 3EZ8A 1FBWA 3E80A 2I07B 1JYXA 1O79A 1IQXA 2J5CA 3S4BA 4FJQA 3K11A 3ACSA 3QPFA 3ACTA 4F10A 1OJPA 4D6HA 3SXXA 1S64B 3VD9A 2D5JA 1SNZA 2NOJA 3SDRA 4OJZA 3NJVA 3D50A 1OJNA 3S9VA 2OW7A 3DYOA 1O6RA 2CISA 4Z4JA 3SQCA 1AVKA 1W6JA 4V1SA 3EJRA 4FNVA 3WUXA 1KSIA 4FNSA 5FO8B 3BLCA 2B39A 3CZJA 4D6FA 1NSRA 1W6CA 2JKAA 3D51A 1VD5A 3T2OA 3T0DA 2CWTA 4KTPA 2JKPA 2H6FB 3TY1A 4GTVB 1QAFA 1GSZA 1O1SB 1Z45A 5FO9B 4EV5A 4M76A 2WVXA 3BUBA 1LOHA 1D8DB 1SIIA 5ILIA 3KSQB 3QXQA 1JRQA 3QRYA 5GW7A 1IVVA 2BRPA 1X1HA 5IK9A 1K1WA 2F1BA 2WCOA 1D6ZA 2XWBB 3RRSA 4D6JA 1N7RA 4GTRB 2RDYA 2BBCA 2CIQA 1UI7A 3SFYB 3UD2A 4GTPB 1IVWA 1QWNA 5CA3A 3F59A 3EJUA 3X3ZA 3W7WA 4KFDA 1F4HA 1US1A 2ZIRB 1NI1B 5JPMB 3KN4A 2PMVA 1A2VA 3ANKA 1SQCA 3H2WA 2C10A 3Q73B 2JF4A 3E33B 1N9AB 3Q78B 1HXCA 3WKHA 1QAZA 1S63B 4ZH5A 2F1AA 3T09A 1SPUA 3D52A 5A1AA 1K1YA 4KKJA 1PS3A 4GTQB 3Q7AB 3D3IA 2WOFA 2QNOA 1D6UA 1XW2A 1TQWA 3MPHA 2W0QA 3LVTA 1JZ7A 3BVWA 1RWHA 1H54A 2WVYA 4NEIA 1LVNA 3E32B 3S4DA 4BZHA 2JG0A 2SQCA 4GTMB 1RJOA 2CFGA 3IAQA 3X3YA 1DYUA 4BTXA 3BUIA 1JZ2A 5DHKA 3WFAA 4D94A 1H39A 2BT3A 2WDAA 4LNBB 1IS9A 3EJTA 3W7TA 3SAEA 1N7NA 3SEPA 1HZFA 2KXRA 3QDEA 4RNLA 2WO0A 1SA4B 3RX8A 2ZZRA 1H37A 1UT9A 3SFXB 1F4AA 1TNUB 2BRWA 4LNGB 1W3YA 1KWFA 3M00A 3MUZ1 3I3BA 3VW5A 5M7IA 1FCEA 5KBPA 1EGUA 1C82A 4F13A 3D5RA 1V5CA 3KQ4A 3DDGA 3AMOA 1LTXB 3SX1A 3PYBA 2GZ6A 4YDOB 2WMGA 1TQSA 1LXMA 3KIIA 1NS7A 2WMIA 3E34B 1LD7B 4QT9A 4D8OA 1TNZB 2JKEA 4D6DA 2F18A 3PYAA 1V7WA 2V8IA 3VD5A 3WIWA 2FV0A 4AYRA 2WYNA 2NVPA 4DLQA 4ZRPA 2YFOA 3Q75B 2WVZA 1KREA 2P0VA 4RNQA 2H6IB 2WMHA 1O5MB 4L0GA 2XN2A 1H36A 1GA2A 1X1JA 3PZ2B 4GTOB 1HCUA 2XFGA 3SDTA 5MEHA 5EATA 2XHNA 4WVBA 3W7UA 4TTGA 3W7SA 2F7PA
chains in the Genus database with same CATH topology
1HM3A 1HN1A 3T2OA 3J7HA 3T0DA 1JZ5A 2JKPA 3TY1A 3VD4A 1NSUA 2FUQA 1Z45A 1N7PA 2WVXA 2CIRA 1LOHA 5JMFA 1JZ4A 3DECA 1MMUA 1K1XA 1NS8A 3E1F1 1DP0A 1NSXA 4MMIA 2HTAA 2BRPA 2HTBA 1X1HA 1K1WA 2WCOA 4DUXA 3AFLA 4D6JA 5JMDA 1TXKA 1N7RA 1NSVA 1YGAA 1YQ2A 1JYVA 1JZ8A 2WW2A 2CIQA 2WW3A 2WMIB 3NREA 4DUVA 1F4HA 5E1QA 1I8QA 3IAPA 3NJXA 3MV01 3T2PA 3NNBA 1PX4A 2E22A 1CB8A 1QAZA 1RWAA 2D73A 3MUY1 3T09A 1RWFA 3T0AA 1K1YA 1NS0A 1JOVA 5A1AA 1NSZA 3ECQA 4D72A 2WMJA 3OS7A 1RW9A 1J0NA 2ZXQA 2FUTA 4OK2A 1F1SA 1JZ3A 1JZ7A 1JYWA 1LF9A 1PX3A 1RWGA 4BZEA 3BGAA 1JYNA 2X03A 2WVXB 3VD7A 4BZGA 1RWHA 3IMHA 2WVYA 3VDBA 3A24A 4NEIA 1HN0A 1MMYA 1NS4A 4AQ0A 1OJMA 4BZHA 4OZVA 1NSSA 1RWCA 1NS2A 3OB8A 1LURA 1NSMA 3IAQA 1HM2A 4OZWA 4D6GA 2BRVX 4D6EA 3DYMA 3T2QA 3VDAA 1JZ2A 3VSMA 4MMHA 3WFAA 3DCDA 2JKAA 1HMUA 2WDAA 2E24A 1HMWA 4D6IA 1N7NA 3SEPA 3K25A 2WZSA 4RNLA 1HV6A 3MV11 1N7OA 2XSGA 4BZFA 1L7KA 1LXKA 1F4AA 3BS6A 2BRWA 2WW0A 1W3YA 1NKGA 3I3DA 3I3BA 3MUZ1 3VDCA 1N7QA 3I3EA 3WVFA 1ULVA 4E1YA 1EGUA 1C82A 4F13A 3OBAA 3T0BA 2WMFA 1UG9A 2ZQ0A 1MMXA 3NFVA 3DYPA 3VD3A 3E7JA 1JZ6A 2WMKA 2WMGA 1SO0A 1LXMA 3E80A 2WMIA 1NS7A 1JYXA 1F9GA 1LF6A 1MMZA 2JKEA 2WW1A 4D6DA 4F10A 1OJPA 4D6HA 3MWXA 3VD5A 3VD9A 3T08A 1SNZA 4OJZA 2WVZA 3NJVA 1OJNA 4J5TA 1MN0A 2WMHA 1J0MA 1OJOA 3DYOA 1X1JA 2CISA 3A0OA 1L7JA 4D6CA 4DUWA 2XHNA 3VSNA 4OK4A 4FNVA 1X1IA 2Q1FA 3BLCA 3CZJA 4D71A 4TTGA 4D6FA 1NSRA 3Q1NA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HM3 A;  1HN1 A;  3T2O A;  3J7H A;  3T0D A;  1JZ5 A;  2JKP A;  3VD4 A;  1NSU A;  2FUQ A;  1Z45 A;  1N7P A;  2WVX A;  2CIR A;  1LOH A;  5JMF A;  1JZ4 A;  3DEC A;  1MMU A;  1K1X A;  1NS8 A;  3E1F 1;  1DP0 A;  1NSX A;  4MMI A;  2HTA A;  2BRP A;  2HTB A;  1X1H A;  1K1W A;  2WCO A;  4DUX A;  3AFL A;  4D6J A;  5JMD A;  1TXK A;  1N7R A;  1NSV A;  1YGA A;  1YQ2 A;  1JYV A;  1JZ8 A;  2WW2 A;  2CIQ A;  2WW3 A;  2WMI B;  3NRE A;  4DUV A;  1F4H A;  5E1Q A;  1I8Q A;  3IAP A;  3NJX A;  3MV0 1;  3T2P A;  3NNB A;  1PX4 A;  2E22 A;  1CB8 A;  1QAZ A;  1RWA A;  2D73 A;  3MUY 1;  3T09 A;  1RWF A;  3T0A A;  1K1Y A;  1NS0 A;  1JOV A;  5A1A A;  1NSZ A;  3ECQ A;  4D72 A;  2WMJ A;  3OS7 A;  1RW9 A;  1J0N A;  2ZXQ A;  2FUT A;  4OK2 A;  1F1S A;  1JZ3 A;  1JZ7 A;  1JYW A;  1LF9 A;  1PX3 A;  1RWG A;  4BZE A;  3BGA A;  1JYN A;  2X03 A;  2WVX B;  3VD7 A;  4BZG A;  1RWH A;  3IMH A;  2WVY A;  3VDB A;  3A24 A;  4NEI A;  1HN0 A;  1MMY A;  1NS4 A;  4AQ0 A;  1OJM A;  4BZH A;  4OZV A;  1NSS A;  1RWC A;  1NS2 A;  3OB8 A;  1LUR A;  1NSM A;  3IAQ A;  1HM2 A;  4OZW A;  4D6G A;  2BRV X;  4D6E A;  3DYM A;  3T2Q A;  3VDA A;  1JZ2 A;  3VSM A;  4MMH A;  3WFA A;  3DCD A;  2JKA A;  1HMU A;  2WDA A;  2E24 A;  1HMW A;  4D6I A;  1N7N A;  3SEP A;  3K25 A;  2WZS A;  4RNL A;  1HV6 A;  3MV1 1;  1N7O A;  2XSG A;  4BZF A;  1L7K A;  1LXK A;  1F4A A;  2BRW A;  2WW0 A;  1W3Y A;  1NKG A;  3I3D A;  3I3B A;  3MUZ 1;  3VDC A;  1N7Q A;  3I3E A;  1ULV A;  4E1Y A;  1EGU A;  1C82 A;  4F13 A;  3OBA A;  3T0B A;  2WMF A;  1UG9 A;  2ZQ0 A;  1MMX A;  3NFV A;  3DYP A;  3VD3 A;  3E7J A;  1JZ6 A;  2WMK A;  2WMG A;  1SO0 A;  1LXM A;  3E80 A;  2WMI A;  1NS7 A;  1JYX A;  1F9G A;  1LF6 A;  1MMZ A;  2JKE A;  2WW1 A;  4D6D A;  4F10 A;  1OJP A;  4D6H A;  3MWX A;  3VD5 A;  3VD9 A;  3T08 A;  1SNZ A;  4OJZ A;  2WVZ A;  3NJV A;  1OJN A;  1MN0 A;  2WMH A;  1J0M A;  1OJO A;  3DYO A;  1X1J A;  2CIS A;  3A0O A;  1L7J A;  4D6C A;  4DUW A;  2XHN A;  3VSN A;  4OK4 A;  4FNV A;  1X1I A;  2Q1F A;  3CZJ A;  4D71 A;  4TTG A;  4D6F A;  1NSR A;  3Q1N A; 
#chains in the Genus database with same CATH topology
 2AFA A;  3PMM A;  3GLY A;  1IQY A;  1OAC A;  1KRF A;  3EQA A;  1N21 A;  4C1S A;  4WVC A;  4YDE B;  1QBQ B;  4AYP A;  3PQI A;  2OW6 A;  2WOH A;  3BUD A;  1TF4 A;  3KLS A;  4JJJ A;  1C3D A;  1N24 A;  1N20 A;  2DRQ A;  3Q7F B;  3E1F 1;  5AGD A;  1NSX A;  1WMO A;  3M73 A;  1TU5 A;  3HXB B;  4WVA A;  3QT3 A;  2HTA A;  2HTB A;  3K5T A;  4DI5 A;  2RI9 A;  4DUX A;  1GLM A;  3AFJ A;  1N94 B;  1V7V A;  3HXD B;  4AYO A;  2WW2 A;  5E2J A;  1AGM A;  2WMI B;  1DCE B;  5IKA A;  5E1Q A;  1I8Q A;  3W7X A;  1W6K A;  1TQV A;  4K35 A;  3M7B A;  5DGQ A;  1N4R B;  3M78 A;  3MUY 1;  2XN1 A;  1RWF A;  2EAB A;  1UI8 A;  3C72 B;  5EAS A;  1JOV A;  1LD8 B;  1IA7 A;  1HWW A;  3T33 A;  5ILH A;  2WGQ A;  3ON6 A;  2KXS A;  5M7Y A;  3DDF A;  1TQT A;  1O1T B;  1PX3 A;  1JYN A;  3CIH A;  2ONH A;  4XUV A;  1O6H A;  1KSC A;  1MMY A;  1NS4 A;  1CLC A;  4EHM B;  1OJM A;  2CFD A;  4OZV A;  3G4F A;  1NSM A;  1TN6 B;  2VN7 A;  4CE7 A;  4D6E A;  1G6I A;  5IK0 A;  1HXG A;  2CQS A;  3DPY B;  3M76 A;  4K3A A;  3DCD A;  1H13 A;  1HMU A;  5ILD A;  1FPP B;  1QWU A;  2XN0 A;  3X42 A;  2E24 A;  1HMW A;  1GAI A;  3EUV B;  4D6I A;  1WU4 A;  3H3K A;  3WC3 A;  2WZS A;  3N0G A;  3REN A;  4D4D A;  3DX3 A;  3K25 A;  3MV1 1;  2EAC A;  3HXC B;  1GXO A;  3WIQ A;  3M7E A;  1N4P B;  2BB5 A;  2EAE A;  4D1I A;  3ALA A;  2FUZ A;  3BS6 A;  1NKG A;  1AYX A;  1O1R B;  2WIN B;  4YCR A;  1X81 B;  3G6J B;  3M7L A;  3VDC A;  3OBA A;  3K7X A;  4E1Y A;  2JJB A;  3BLB A;  2EAD A;  2WMF A;  1UG9 A;  2AHF A;  2ZQ0 A;  3DYP A;  3Q79 B;  3EU5 B;  2F0Y B;  4L6X A;  1NC5 A;  3M74 A;  2R2L B;  3KSL B;  1TNB B;  1JZ6 A;  1SA5 B;  1DL2 A;  1G87 A;  5JPN B;  1SO0 A;  3BVX A;  3DX0 A;  1HXA A;  1F9G A;  2CFW A;  2AHG A;  1WMN A;  2WW1 A;  4EV2 A;  2F6D A;  3WA2 X;  1W7C A;  4D4A A;  2D1W A;  5ILK A;  3A3V A;  2H6H B;  2BB6 A;  3NBJ A;  3MWX A;  1H35 A;  3SDU A;  1JS4 A;  3WIR A;  1H14 A;  3SDQ A;  1HXK A;  4FNU A;  1AV4 A;  1N1Z A;  4J5T A;  3WKG A;  1G9G A;  1UMP A;  1J0M A;  1OJO A;  1R76 A;  4D4C A;  5IM1 A;  2F7O A;  1L7J A;  4D6C A;  1R33 A;  1H3A A;  5IKH A;  4FNR A;  4DUW A;  1X1I A;  2A8Z A;  4BOJ A;  1NL4 B;  1TNO B;  3Q1N A;  1HM3 A;  4LIX A;  3DX2 A;  4GTT B;  1IVU A;  1HN1 A;  3J7H A;  3HIG A;  1R34 A;  1JCS B;  3DX1 A;  3KBU C;  1GAH A;  1L2A A;  2ONG A;  2GH4 A;  2V3P A;  3VD4 A;  3HXE B;  3VXD A;  2Y74 A;  2DRR A;  1GXN A;  2CIR A;  3QR8 A;  5JMF A;  1JZ4 A;  3E6U A;  3AMO B;  3DEC A;  1MMU A;  1K1X A;  1DP0 A;  3QFY A;  4MMI A;  1D6Y A;  1FT1 B;  4D1J A;  4CJ1 A;  2A73 B;  3EJQ A;  1H3C A;  3M75 A;  1TXK A;  4FNQ A;  2WYH A;  3DSX B;  3LOY A;  2G02 A;  1JYV A;  2V8J A;  3DSV B;  2RGK A;  3PZ1 B;  3MI6 A;  3PZ3 B;  3W5M A;  4ONT A;  2FYV A;  4DOD A;  3NRE A;  1PU4 A;  1N95 B;  1QX1 A;  5CD2 A;  4AYQ A;  4BOK A;  3T2P A;  3NNB A;  3X3X A;  4BTW A;  1PX4 A;  3D4Z A;  2CG1 A;  4GTS B;  2DRS A;  1KSD A;  1QSJ A;  1RWA A;  2D73 A;  1NS0 A;  3W5N A;  1G9J A;  1N9E A;  2DRO A;  2WMJ A;  4BTY A;  1RW9 A;  1N22 A;  2FUT A;  4MBG B;  4OK2 A;  3SDV A;  2VN4 A;  3ANI A;  1JYW A;  4D4B A;  3BGA A;  3G4D A;  2X03 A;  2WVX B;  3VD7 A;  5C05 A;  3DST B;  3IMH A;  3VDB A;  1AVL A;  2CFK A;  4KTR A;  3A24 A;  1W6G A;  3P5R A;  5IL3 A;  1EKM A;  1NS2 A;  1RWC A;  3NBB A;  1LUR A;  1HM2 A;  2WYI A;  2ZBL A;  1L1Y A;  3E37 B;  3ANJ A;  4OZW A;  5GZK A;  4D6G A;  2YX9 A;  1N1B A;  3KBT C;  1N23 A;  1F9D A;  1KZO B;  2IEJ B;  4V1R A;  4MMH A;  2E2T A;  3BVU A;  2E2U A;  1FO2 A;  4FUS A;  1K72 A;  4KFF A;  1W4N A;  4Z4L A;  4BZF A;  1L7K A;  2OKX A;  3PGB A;  1LXK A;  3BVT A;  3EJS A;  1JCQ B;  2WW0 A;  2YFN A;  1QAL A;  1WU6 A;  3I3D A;  4FNT A;  4FXK B;  1N7Q A;  2OQE C;  3WVF A;  1ULV A;  3QSP A;  3HII A;  1WZZ A;  3H7L A;  3T0B A;  3S4C A;  3HI7 A;  4KKI A;  2PNC A;  2Y73 A;  2CG0 A;  3NFV A;  3X17 A;  1V5D A;  5KKB A;  3E7J A;  4ZRQ A;  2D8L A;  3P5P A;  2CWV A;  3QWT A;  1V7X A;  4TXT A;  1O7D D;  3QG0 A;  5IL8 A;  1FMI A;  1N4S B;  1LF6 A;  1MMZ A;  1H12 A;  3WKF A;  2OOV C;  4L9P B;  1KFG A;  2CWU A;  2OOV A;  1W2Z A;  3EJP A;  3T08 A;  1SIH A;  4CJ0 A;  3M02 A;  1IVX A;  3QT9 A;  1MN0 A;  2WY8 A;  2G0D A;  3A0O A;  2GOX A;  3VSN A;  4OK4 A;  2Q1F A;  5IK6 A;  3P2C A;  3D5S A;  4D71 A;  3M71 A;  3UD1 A;  1W5Z A;  1FP3 A;  1O6Q A;  4ZH1 A;  3U7V A;  2CFL A;  4UFC A;  1JZ5 A;  4DLO A;  3BUP A;  2ALW A;  1NSU A;  2FUQ A;  4Q2B A;  1N7P A;  3E73 A;  5DGR A;  3RX5 A;  4WU0 A;  1WMP A;  1MZC B;  2V3N A;  1NS8 A;  2V8K A;  3QXF A;  2F7R A;  1WU5 A;  1N4Q B;  2C11 A;  3RJ3 A;  1TN8 B;  3AFL A;  3EU8 A;  5JMD A;  5FO7 B;  1FBO A;  1NSV A;  4KFE A;  1YGA A;  1TNY B;  1YQ2 A;  3X41 A;  3OXU A;  1JZ8 A;  2B4F A;  2WW3 A;  3LZ9 A;  1XWT A;  4FNP A;  4DUV A;  2ZL8 A;  1FT2 B;  3NJX A;  3IAP A;  3M72 A;  3MV0 1;  2CQT A;  5CZL A;  2FV1 A;  5EAU A;  3TF4 A;  1F9O A;  1KS8 A;  5ILJ A;  1FO3 A;  3OED A;  2E22 A;  1CB8 A;  3M01 A;  3CZN A;  3QFZ A;  3T0A A;  2PN5 A;  3RSY A;  3HXF B;  1NSZ A;  3ECQ A;  2WII B;  3DSU B;  3GT5 A;  4MU9 A;  1D8E B;  4D72 A;  3OS7 A;  1FAE A;  1J0N A;  1X9D A;  3E30 B;  2ZXQ A;  2RI8 A;  1HX9 A;  4Q88 A;  1F1S A;  1JZ3 A;  1LF9 A;  1RWG A;  3DRA B;  4BZE A;  3N0F A;  5GY3 A;  4BZG A;  1HN0 A;  1JCR B;  1QAK A;  4AQ0 A;  3BUQ A;  1RQ5 A;  1NSS A;  3OB8 A;  3WKI A;  4TF4 A;  1GHQ A;  3BVV A;  3T0U A;  1IU7 A;  1NXC A;  2OQE A;  3N9H A;  1RKY A;  3DSS B;  3PZ4 B;  2BRV X;  3DYM A;  2E2V A;  3T2Q A;  3VDA A;  2BED B;  3VSM A;  2Z07 A;  1H3B A;  2XQW A;  3RX7 A;  1IA6 A;  3M7C A;  3M77 A;  4FXG B;  1HV6 A;  3CV5 A;  5ILZ A;  1N7O A;  2YIK A;  2XWJ B;  1KZP B;  4LNV A;  2XSG A;  1DOG A;  4GL3 A;  2H6G B;  3CU7 A;  2WY7 A;  1KKT A;  1XWQ A;  4ZG8 A;  4GAX A;  3D4Y A;  1TN7 B;  3X40 A;  3I3E A;  3S4A A;  1CEM A;  2ZIS B;  1GXM A;  1TQU A;  1QQF A;  2F7Q A;  4DOE A;  2FBA A;  5DHI A;  1HTY A;  3WA3 A;  1MMX A;  5ILY A;  3DSW B;  3VD3 A;  4EL8 A;  5FOB B;  3GZK A;  2WMK A;  3CZS A;  3DX4 A;  3EZ8 A;  1FBW A;  3E80 A;  2I07 B;  1JYX A;  1O79 A;  1IQX A;  2J5C A;  3S4B A;  4FJQ A;  3K11 A;  3ACS A;  3QPF A;  3ACT A;  4F10 A;  1OJP A;  4D6H A;  3SXX A;  1S64 B;  3VD9 A;  2D5J A;  1SNZ A;  2NOJ A;  3SDR A;  4OJZ A;  3NJV A;  3D50 A;  1OJN A;  3S9V A;  2OW7 A;  3DYO A;  1O6R A;  2CIS A;  4Z4J A;  3SQC A;  1AVK A;  1W6J A;  4V1S A;  3EJR A;  4FNV A;  3WUX A;  1KSI A;  4FNS A;  5FO8 B;  3BLC A;  2B39 A;  3CZJ A;  4D6F A;  1NSR A;  1W6C A;  2JKA A;  3D51 A;  1VD5 A;  3T2O A;  3T0D A;  2CWT A;  4KTP A;  2JKP A;  2H6F B;  3TY1 A;  4GTV B;  1QAF A;  1GSZ A;  1O1S B;  1Z45 A;  5FO9 B;  4EV5 A;  4M76 A;  2WVX A;  3BUB A;  1LOH A;  1D8D B;  1SII A;  5ILI A;  3KSQ B;  3QXQ A;  1JRQ A;  3QRY A;  5GW7 A;  1IVV A;  2BRP A;  1X1H A;  5IK9 A;  1K1W A;  2F1B A;  2WCO A;  1D6Z A;  2XWB B;  3RRS A;  4D6J A;  1N7R A;  4GTR B;  2RDY A;  2BBC A;  2CIQ A;  1UI7 A;  3SFY B;  3UD2 A;  4GTP B;  1IVW A;  1QWN A;  5CA3 A;  3F59 A;  3EJU A;  3X3Z A;  3W7W A;  4KFD A;  1F4H A;  1US1 A;  2ZIR B;  1NI1 B;  5JPM B;  3KN4 A;  2PMV A;  1A2V A;  3ANK A;  1SQC A;  3H2W A;  2C10 A;  3Q73 B;  2JF4 A;  3E33 B;  1N9A B;  3Q78 B;  1HXC A;  3WKH A;  1QAZ A;  1S63 B;  4ZH5 A;  2F1A A;  3T09 A;  1SPU A;  3D52 A;  5A1A A;  1K1Y A;  4KKJ A;  1PS3 A;  4GTQ B;  3Q7A B;  3D3I A;  2WOF A;  2QNO A;  1D6U A;  1XW2 A;  1TQW A;  3MPH A;  2W0Q A;  3LVT A;  1JZ7 A;  3BVW A;  1RWH A;  1H54 A;  2WVY A;  4NEI A;  1LVN A;  3E32 B;  3S4D A;  4BZH A;  2JG0 A;  2SQC A;  4GTM B;  1RJO A;  2CFG A;  3IAQ A;  3X3Y A;  1DYU A;  4BTX A;  3BUI A;  1JZ2 A;  5DHK A;  3WFA A;  4D94 A;  1H39 A;  2BT3 A;  2WDA A;  4LNB B;  1IS9 A;  3EJT A;  3W7T A;  3SAE A;  1N7N A;  3SEP A;  1HZF A;  2KXR A;  3QDE A;  4RNL A;  2WO0 A;  1SA4 B;  3RX8 A;  2ZZR A;  1H37 A;  1UT9 A;  3SFX B;  1F4A A;  1TNU B;  2BRW A;  4LNG B;  1W3Y A;  1KWF A;  3M00 A;  3MUZ 1;  3I3B A;  3VW5 A;  5M7I A;  1FCE A;  5KBP A;  1EGU A;  1C82 A;  4F13 A;  3D5R A;  1V5C A;  3KQ4 A;  3DDG A;  3AMO A;  1LTX B;  3SX1 A;  3PYB A;  2GZ6 A;  4YDO B;  2WMG A;  1TQS A;  1LXM A;  3KII A;  1NS7 A;  2WMI A;  3E34 B;  1LD7 B;  4QT9 A;  4D8O A;  1TNZ B;  2JKE A;  4D6D A;  2F18 A;  3PYA A;  1V7W A;  2V8I A;  3VD5 A;  3WIW A;  2FV0 A;  4AYR A;  2WYN A;  2NVP A;  4DLQ A;  4ZRP A;  2YFO A;  3Q75 B;  2WVZ A;  1KRE A;  2P0V A;  4RNQ A;  2H6I B;  2WMH A;  1O5M B;  4L0G A;  2XN2 A;  1H36 A;  1GA2 A;  1X1J A;  3PZ2 B;  4GTO B;  1HCU A;  2XFG A;  3SDT A;  5MEH A;  5EAT A;  2XHN A;  4WVB A;  3W7U A;  4TTG A;  3W7S A;  2F7P A; 
#chains in the Genus database with same CATH homology
 1HM3 A;  1HN1 A;  3T2O A;  3J7H A;  3T0D A;  1JZ5 A;  2JKP A;  3TY1 A;  3VD4 A;  1NSU A;  2FUQ A;  1Z45 A;  1N7P A;  2WVX A;  2CIR A;  1LOH A;  5JMF A;  1JZ4 A;  3DEC A;  1MMU A;  1K1X A;  1NS8 A;  3E1F 1;  1DP0 A;  1NSX A;  4MMI A;  2HTA A;  2BRP A;  2HTB A;  1X1H A;  1K1W A;  2WCO A;  4DUX A;  3AFL A;  4D6J A;  5JMD A;  1TXK A;  1N7R A;  1NSV A;  1YGA A;  1YQ2 A;  1JYV A;  1JZ8 A;  2WW2 A;  2CIQ A;  2WW3 A;  2WMI B;  3NRE A;  4DUV A;  1F4H A;  5E1Q A;  1I8Q A;  3IAP A;  3NJX A;  3MV0 1;  3T2P A;  3NNB A;  1PX4 A;  2E22 A;  1CB8 A;  1QAZ A;  1RWA A;  2D73 A;  3MUY 1;  3T09 A;  1RWF A;  3T0A A;  1K1Y A;  1NS0 A;  1JOV A;  5A1A A;  1NSZ A;  3ECQ A;  4D72 A;  2WMJ A;  3OS7 A;  1RW9 A;  1J0N A;  2ZXQ A;  2FUT A;  4OK2 A;  1F1S A;  1JZ3 A;  1JZ7 A;  1JYW A;  1LF9 A;  1PX3 A;  1RWG A;  4BZE A;  3BGA A;  1JYN A;  2X03 A;  2WVX B;  3VD7 A;  4BZG A;  1RWH A;  3IMH A;  2WVY A;  3VDB A;  3A24 A;  4NEI A;  1HN0 A;  1MMY A;  1NS4 A;  4AQ0 A;  1OJM A;  4BZH A;  4OZV A;  1NSS A;  1RWC A;  1NS2 A;  3OB8 A;  1LUR A;  1NSM A;  3IAQ A;  1HM2 A;  4OZW A;  4D6G A;  2BRV X;  4D6E A;  3DYM A;  3T2Q A;  3VDA A;  1JZ2 A;  3VSM A;  4MMH A;  3WFA A;  3DCD A;  2JKA A;  1HMU A;  2WDA A;  2E24 A;  1HMW A;  4D6I A;  1N7N A;  3SEP A;  3K25 A;  2WZS A;  4RNL A;  1HV6 A;  3MV1 1;  1N7O A;  2XSG A;  4BZF A;  1L7K A;  1LXK A;  1F4A A;  3BS6 A;  2BRW A;  2WW0 A;  1W3Y A;  1NKG A;  3I3D A;  3I3B A;  3MUZ 1;  3VDC A;  1N7Q A;  3I3E A;  3WVF A;  1ULV A;  4E1Y A;  1EGU A;  1C82 A;  4F13 A;  3OBA A;  3T0B A;  2WMF A;  1UG9 A;  2ZQ0 A;  1MMX A;  3NFV A;  3DYP A;  3VD3 A;  3E7J A;  1JZ6 A;  2WMK A;  2WMG A;  1SO0 A;  1LXM A;  3E80 A;  2WMI A;  1NS7 A;  1JYX A;  1F9G A;  1LF6 A;  1MMZ A;  2JKE A;  2WW1 A;  4D6D A;  4F10 A;  1OJP A;  4D6H A;  3MWX A;  3VD5 A;  3VD9 A;  3T08 A;  1SNZ A;  4OJZ A;  2WVZ A;  3NJV A;  1OJN A;  4J5T A;  1MN0 A;  2WMH A;  1J0M A;  1OJO A;  3DYO A;  1X1J A;  2CIS A;  3A0O A;  1L7J A;  4D6C A;  4DUW A;  2XHN A;  3VSN A;  4OK4 A;  4FNV A;  1X1I A;  2Q1F A;  3BLC A;  3CZJ A;  4D71 A;  4TTG A;  4D6F A;  1NSR A;  3Q1N A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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