1HM2A

Active site of chondroitinase ac lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis
Total Genus 239
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
239
sequence length
674
structure length
674
Chain Sequence
GTAELIMKRVMLDLKKPLRNMDKVAEKNLNTLQPDGSWKDVPYKDDAMTNWLPNNHLLQLETIIQAYIEKDSHYYGDDKVFDQISKAFKYWYDSDPKSRNWWHNEIATPQALGEMLILMRYGKKPLDEALVHKLTERMKRGEPEKKTGANKTDIALHYFYRALLTSDEALLSFAVKELFYPVQFVHYEEGLQYDYSYLQHGPQLQISSYGAVFITGVLKLANYVRDTPYALSTEKLAIFSKYYRDSYLKAIRGSYMDFNVEGRGVSRPDILNKKAEKKRLLVAKMIDLKHTEEWADAIARTDSTVAAGYKIEPYHHQFWNGDYVQHLRPAYSFNVRMVSKRTRRSESGNKENLLGRYLSDGATNIQLRGPEYYNIMPVWEWDKIPGITSRDYLTDRPLTKLWGEQGSNDFAGGVSDGVYGASAYALDYDSLQAKKAWFFFDKEIVCLGAGINSNAPENITTTLNQSWLNGPVISTAGKTGRGKITTFKAQGQFWLLHDAIGYYFPEGANLSLSTQSQKGNWFHINNSHSKDEVSGDVFKLWINHGARPENAQYAYIVLPGINKPEEIKKYNGTAPKVLANTNQLQAVYHQQLDMVQAIFYTAGKLSVAGIEIETDKPCAVLIKHINGKQVIWAADPLQKEKTAVLSIRDLKTGKTNRVKIDFPQQEFAGATVEL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords CHONDROITINASE AC
publication title Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis.
pubmed doi rcsb
source organism Pedobacter heparinus
molecule tags Lyase
total genus 239
structure length 674
sequence length 674
ec nomenclature ec 4.2.2.5: Chondroitin AC lyase.
pdb deposition date 2000-12-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02278 Lyase_8 Polysaccharide lyase family 8, super-sandwich domain
A PF02884 Lyase_8_C Polysaccharide lyase family 8, C-terminal beta-sandwich domain
A PF08124 Lyase_8_N Polysaccharide lyase family 8, N terminal alpha-helical domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.50.10.100 Mainly Alpha Alpha/alpha barrel Glycosyltransferase Chondroitin AC/alginate lyase 1hm2A01
2.60.220.10 Mainly Beta Sandwich Chondroitinase Ac; Chain A, domain 3 Polysaccharide lyase family 8-like, C-terminal 1hm2A03
2.70.98.10 Mainly Beta Distorted Sandwich Beta-galactosidase; Chain A, domain 5 Beta-galactosidase; Chain A, domain 5 1hm2A02
2X03A 3DYPA 2WMJA 3CZJA 3VSMA 4MMHA 3VDCA 3VD7A 3IMHA 1X1IA 1RW9A 1JYXA 2WW3A 1HM2A 2Q1FA 3Q1NA 1HN1A 5JMDA 4OZWA 4RNLA 1OJOA 1RWCA 3VD3A 4MMIA 4DUVA 1MMYA 3T2PA 1RWHA 3MV11 3BGAA 4TTGA 3J7HA 3IAPA 1JZ4A 3NNBA 3T2QA 1NS4A 3DYMA 1DP0A 3DECA 4E1YA 4DUWA 2XSGA 1N7OA 1SO0A 3A0OA 5JMFA 2FUQA 1NSRA 2WVZA 3T0AA 1MMUA 3T2OA 1SNZA 1NS2A 4AQ0A 1JYNA 3E80A 1LOHA 2BRPA 2WVXA 3I3BA 1LURA 3T0BA 3E7JA 1K1WA 1EGUA 3MUZ1 1JZ3A 1J0NA 1PX3A 1LF9A 3NJXA 1X1HA 4OZVA 1JZ2A 3I3EA 2ZXQA 1RWFA 3IAQA 1F4HA 3A24A 1HMUA 2HTAA 3T09A 1LXKA 1HMWA 3I3DA 1JOVA 1L7KA 3ECQA 1UG9A 1YQ2A 1F1SA 4D71A 2D73A 2WVYA 2JKAA 2WMGA 1NSUA 1PX4A 2XHNA 1JYWA 2E22A 3OS7A 1ULVA 1N7QA 1JZ7A 1F9GA 1HM3A 2BRVX 4D6EA 1I8QA 2WVXB 2WW1A 1N7NA 1C82A 1Z45A 4BZHA 1K1YA 5E1QA 4D72A 3VSNA 2WZSA 2WW0A 3VDAA 3DCDA 4F10A 2CISA 3OBAA 1W3YA 4D6FA 3MV01 4BZGA 2WMFA 1JZ6A 2BRWA 4BZFA 3NREA 1MMZA 1JZ5A 4NEIA 3NJVA 4D6DA 4D6IA 2JKEA 1OJMA 3MUY1 1HV6A 4OK4A 1JZ8A 3VD9A 1NSSA 4OJZA 4F13A 1RWAA 1NSMA 1LXMA 1NKGA 3OB8A 1N7PA 1JYVA 2HTBA 1NS8A 2WMIA 4D6CA 2JKPA 1NS7A 1TXKA 1YGAA 1OJNA 3DYOA 1MN0A 2WMHA 4D6HA 1MMXA 3E1F1 3WFAA 2CIRA 1NSVA 5A1AA 1LF6A 1NSZA 4OK2A 2WMKA 3T0DA 1CB8A 1NSXA 3T08A 3MWXA 3VDBA 3K25A 4FNVA 4BZEA 1L7JA 2WDAA 2ZQ0A 1RWGA 2FUTA 2WCOA 1F4AA 1N7RA 2WW2A 3AFLA 1OJPA 4D6GA 2E24A 2WMIB 1HN0A 3VD5A 1K1XA 1NS0A 3NFVA 4DUXA 3SEPA 2CIQA 4D6JA 1QAZA 3VD4A 1X1JA 1J0MA
chains in the Genus database with same CATH superfamily
1O6RA 3CZJA 1D8DB 2WY8A 4MMHA 1H3AA 3G6JB 1GXNA 1RW9A 1JYXA 3Q7AB 4D4DA 1L2AA 1HM2A 2A8ZA 2B4FA 2E2TA 1KWFA 3RENA 5IL3A 1N4SB 3DSTB 3DX1A 3SDQA 3W7TA 1HXKA 1RWCA 1QAKA 1HXAA 5IM1A 3HXFB 1MMYA 3LZ9A 4Q2BA 4BOJA 1US1A 3QDEA 3T2PA 1N4PB 4BTXA 4TTGA 2I07B 3PZ4B 1JCSB 1JCQB 5MEHA 1IVUA 3KBTC 1X81B 1NC5A 2EABA 3GLYA 3EJPA 5CD2A 1NS4A 4J5TA 3T2QA 3K5TA 1O5MB 1TF4A 3S4CA 4TF4A 3WKIA 3RX8A 4E1YA 1DP0A 3SXXA 1G9JA 1G87A 5CZLA 1N7OA 2WYNA 3A0OA 3RJ3A 1H14A 1LTXB 3PZ3B 5ILDA 1JYNA 3H3KA 1FBOA 4EHMB 1EKMA 4AYRA 3D4ZA 2PN5A 3CU7A 3E7JA 1N22A 2AHGA 1JZ3A 2OOVC 4GTSB 2ALWA 1LF9A 2CFLA 2BBCA 3WVFA 1JZ2A 4OZVA 1FO3A 3I3EA 3W7SA 1RWFA 2QNOA 3K11A 1IQYA 3A24A 3X40A 3ON6A 3RSYA 1HX9A 1HXCA 1KKTA 3EJRA 1TQSA 4ONTA 2WVYA 2DRSA 1N21A 2EACA 1HTYA 2YX9A 2OOVA 1JZ7A 1V7WA 2F7OA 3S4AA 1D6ZA 4GL3A 1IQXA 5M7IA 4RNQA 3G4DA 1R34A 1KSCA 3KBUC 5E1QA 5JPNB 2OKXA 1WMOA 2OW6A 3OBAA 3QFYA 4D6FA 3MV01 5CA3A 3BVXA 4BTYA 1JZ6A 2BB6A 5IKHA 3M73A 3K7XA 2D5JA 3NREA 2DRRA 1GAHA 4GTVB 2RGKA 2NOJA 1JZ8A 3DSSB 4F13A 1RWAA 4D4CA 1AV4A 1AVLA 4WVBA 3HI7A 5DGRA 5IK9A 3M02A 2WOFA 5ILYA 3M7LA 4V1RA 4D6CA 2JKPA 1HXGA 1TXKA 1YGAA 1OJNA 2WMHA 1V5DA 4D6HA 3DX3A 1W4NA 1AGMA 2EAEA 2XN0A 1OACA 2F1AA 1H3CA 1HWWA 3KSLB 1N4QB 5A1AA 2CFWA 3MWXA 3M75A 4FNUA 2GOXA 1JS4A 1O79A 3M00A 4AYOA 3KN4A 2WCOA 2WIIB 1GXOA 1S64B 3M72A 2WW2A 3HIIA 4D1IA 3Q73B 4DLOA 1UI8A 2WMIB 3DDGA 1K1XA 1TN7B 5FOBB 3SEPA 3NBJA 3E32B 4ZRQA 4D4BA 2H6IB 2F18A 1J0MA 4D1JA 2F7QA 1UT9A 3PGBA 1QQFA 3EU5B 2ZZRA 2WO0A 3D52A 3MI6A 3VDCA 3DX0A 1XWTA 3TF4A 1X1IA 2CG0A 3HXCB 1FO2A 1GA2A 2ZIRB 3HIGA 5ILKA 3M76A 1DYUA 1O1TB 3Q1NA 3X41A 5FO9B 1L1YA 1H35A 5JMDA 4OZWA 4RNLA 2JF4A 5FO7B 1NI1B 2RI8A 3OEDA 4D94A 4DOEA 1H36A 4DUVA 2V3NA 3E30B 1QX1A 1RWHA 1QAFA 3S4DA 1GLMA 2CFGA 1HZFA 1XW2A 2WYIA 1RQ5A 1O6QA 3IAPA 1JZ4A 3VW5A 3QRYA 5IK0A 3DYMA 3F59A 4DUWA 2XSGA 1SO0A 2ZL8A 2SQCA 5JMFA 5KBPA 3T0AA 4D4AA 2ZBLA 2BB5A 3X3ZA 5ILJA 3SFXB 3T2OA 3Q75B 1TQTA 1IU7A 1QSJA 3BVTA 2BRPA 3I3BA 5ILZA 3T0BA 1LURA 5DHKA 2OQEC 1K1WA 2CWTA 3RX5A 1J0NA 2JG0A 3VXDA 2FBAA 2CQTA 3ACTA 3ACSA 2WGQA 3WKHA 4ZH5A 5M7YA 3IAQA 3D3IA 4GTRB 1FMIA 5IKAA 4L9PB 1F4HA 2HTAA 3BUIA 5EATA 5JPMB 3DPYB 1LXKA 4L0GA 1L7KA 1UG9A 4V1SA 3N0GA 4ZH1A 2D73A 3WIWA 5ILHA 2JKAA 2WOHA 1W2ZA 4C1SA 2XFGA 1N95B 3BUBA 2XHNA 2OQEA 1IVWA 3P5PA 3W7UA 3PQIA 2Y74A 1N94B 4DI5A 2F1BA 1F9GA 2WVXB 2WW1A 1N7NA 1C82A 1Z45A 1F9OA 4BTWA 2G02A 3EUVB 3VSNA 3Q78B 4KTPA 4F10A 3EU8A 3QXFA 4BZGA 1CEMA 4KFDA 1O1SB 1N1BA 3WIRA 4FXKB 1MMZA 1JZ5A 3NJVA 3ANIA 4D6DA 1OJMA 2XQWA 5EAUA 4YDEB 2G0DA 1NSSA 1DCEB 2CWUA 3BLCA 1IVVA 1KS8A 3UD1A 3W7WA 1W6JA 2HTBA 2B39A 1WU4A 1FBWA 2WMIA 1GAIA 1TN6B 3MPHA 2CFKA 1MN0A 4LIXA 1LF6A 1MZCB 4OK2A 3D51A 1CB8A 1NSXA 3T08A 2FV0A 1X9DA 3VDBA 1W6CA 2V8IA 4BZEA 1TNUB 1QALA 2AFAA 1R76A 4LNGB 1TQVA 2XWBB 4FJQA 3SDVA 3SAEA 1QBQB 1RWGA 3OXUA 1WU5A 2XN1A 3M7BA 1H37A 2DRQA 3PYBA 4KTRA 3WUXA 2YFOA 2H6GB 3AFLA 4KFFA 3VD5A 4Z4JA 2ONHA 1TNZB 1NS0A 4AYPA 1SA5B 4GTMB 4MU9A 1S63B 4FNTA 2YIKA 3DYPA 1IA7A 3VSMA 2V8KA 3VD7A 2OW7A 5IK6A 3S4BA 2YFNA 1N4RB 3CZNA 3E33B 2Q1FA 1K72A 3M71A 4K35A 3DSWB 2WY7A 1V7VA 2FV1A 3BUQA 3VD3A 5GY3A 1LVNA 1XWQA 3BS6A 1N24A 2NVPA 5EASA 3EZ8A 3U7VA 2H6FB 1TQUA 3BGAA 2F0YB 3MV11 1G9GA 4ZRPA 1KFGA 4K3AA 3J7HA 3BVVA 1H54A 3M78A 2KXSA 3LVTA 1AYXA 3DECA 1N9AB 4EV5A 3NBBA 2DROA 3EQAA 2FUZA 3M77A 4GTOB 2FUQA 1NSRA 2WVZA 4UFCA 3DSUB 1SIHA 1H3BA 1TQWA 3SX1A 3E80A 4D8OA 1LOHA 2WVXA 1W5ZA 1EGUA 1X1HA 3D5SA 3DX4A 3WA2X 1V5CA 3AFJA 5KKBA 4L6XA 3QSPA 3M74A 3M7CA 3C72B 3T09A 3PMMA 1H12A 1JCRB 3I3DA 2R2LB 1JOVA 3ECQA 2CQSA 1YQ2A 2CFDA 1WZZA 2J5CA 2RDYA 3LOYA 3HXEB 4FXGB 2E22A 1W7CA 3OS7A 3GZKA 1ULVA 2BT3A 1JYWA 1N7QA 2KXRA 5IL8A 1HM3A 2BRVX 4D6EA 1I8QA 1GXMA 1D6YA 1TNOB 3DX2A 3EJTA 3S9VA 4BZHA 4EL8A 3W5MA 3CZSA 2CG1A 4D72A 1LD8B 4FNSA 3X42A 2WW0A 3VDAA 4DLQA 3SDUA 1W3YA 2Z07A 2WMFA 2PMVA 2BRWA 4BZFA 3KLSA 3ALAA 2JKEA 3QT9A 3MUY1 1HV6A 4OK4A 4DODA 4OJZA 2RI9A 1SPUA 2D1WA 1IA6A 1NSMA 3M7EA 3OB8A 1KZPB 1N7PA 2XWJB 4LNVA 5AGDA 3WKGA 1JYVA 1JRQA 3KIIA 1WU6A 1TU5A 1H39A 3BUDA 4WVCA 3DYOA 1KREA 3TY1A 2CIRA 5GZKA 1TNYB 3E34B 4LNBB 3BLBA 3N9HA 1IVXA 4KKJA 1SA4B 2W0QA 3T0DA 1V7XA 2ZISB 3DDFA 5ILIA 4AYQA 1KSIA 3WA3A 1VD5A 3WIQA 3K25A 3QWTA 2CWVA 3HXBB 3EJUA 3ANKA 3T33A 3E6UA 2ZQ0A 2FUTA 4GTTB 1FT2B 3PYAA 1LD7B 1N7RA 2H6HB 3W5NA 2D8LA 1R33A 1OJPA 2AHFA 1HN0A 4FUSA 3W7XA 3NFVA 4DUXA 1FP3A 1O6HA 4D6JA 1QAZA 2X03A 3WC3A 1HCUA 2WMJA 3CIHA 4FNRA 4WVAA 2Y73A 1C3DA 1KSDA 3IMHA 3RRSA 3Q7FB 4CJ0A 2WW3A 2V8JA 1QWUA 4FNQA 3AMOB 4ZG8A 3BVUA 1PS3A 3QFZA 1HN1A 1OJOA 5GW7A 3CV5A 3M01A 3Q79B 2PNCA 4MMIA 1D6UA 1N9EA 5C05A 1GHQA 2A73B 1RJOA 4GAXA 4XUVA 2WYHA 1A2VA 1CLCA 2XN2A 4BOKA 3NNBA 1IS9A 1DL2A 3QG0A 3A3VA 2IEJB 1NXCA 3DSVB 4KKIA 3EJSA 1MMUA 4EV2A 1SNZA 1W6GA 1TNBB 1NS2A 4AQ0A 2C10A 4YDOB 3H7LA 2F7RA 1UI7A 4Z4LA 4M76A 1KRFA 1WMPA 3MUZ1 5E2JA 1PX3A 3PZ1B 3NJXA 4QT9A 4JJJA 1F9DA 2ZXQA 3GT5A 3X3YA 1W6KA 1HMUA 1UMPA 2ONGA 3DSXB 2GH4A 1HMWA 3RX7A 5FO8B 2F7PA 3SQCA 2F6DA 3BVWA 1F1SA 1GSZA 1TN8B 4D71A 2FYVA 3SDRA 1FT1B 2C11A 2WMGA 2EADA 3DRAB 3QT3A 1NSUA 1PX4A 1DOGA 1WMNA 3QR8A 2VN4A 3KSQB 3PZ2B 3D5RA 1G6IA 2VN7A 4MBGB 1D8EB 3D4YA 1K1YA 4YCRA 1SIIA 3G4FA 1QWNA 3D50A 2WZSA 3BUPA 2JJBA 3DCDA 3EJQA 1RKYA 2CISA 1AVKA 1N23A 3P5RA 4CE7A 4Q88A 1SQCA 4NEIA 1KZOB 4D6IA 3VD9A 3X17A 3UD2A 4GTPB 3X3XA 1LXMA 1NKGA 1FAEA 3SFYB 1NS8A 3QXQA 3HXDB 1NS7A 1N1ZA 3SDTA 3E37B 1FPPB 3E73A 2P0VA 1MMXA 1NSVA 1N20A 3E1F1 3WFAA 3ANJA 1NSZA 1O7DD 4FNPA 2WMKA 3T0UA 4WU0A 1NL4B 1FCEA 1O1RB 4FNVA 1PU4A 3H2WA 3P2CA 1L7JA 5DGQA 4GTQB 1H13A 2WDAA 3QPFA 2E2UA 3AMOA 2WINB 1F4AA 4TXTA 4CJ1A 2BEDB 2E2VA 2V3PA 4D6GA 2E24A 2GZ6A 3N0FA 3WKFA 5DHIA 2CIQA 4KFEA 3KQ4A 3VD4A 1X1JA
chains in the Genus database with same CATH topology
2X03A 3DYPA 2WMJA 3CZJA 3VSMA 4MMHA 3VDCA 3VD7A 3IMHA 1X1IA 1RW9A 1JYXA 2WW3A 1HM2A 2Q1FA 3Q1NA 1HN1A 5JMDA 4OZWA 4RNLA 1OJOA 1RWCA 3VD3A 4MMIA 4DUVA 1MMYA 3BS6A 3T2PA 1RWHA 3MV11 3BGAA 4TTGA 3J7HA 3IAPA 1JZ4A 3NNBA 3T2QA 1NS4A 4J5TA 3DYMA 1DP0A 3DECA 4E1YA 4DUWA 2XSGA 1N7OA 1SO0A 3A0OA 5JMFA 2FUQA 1NSRA 2WVZA 3T0AA 1MMUA 3T2OA 1SNZA 1NS2A 4AQ0A 1JYNA 3E80A 1LOHA 2BRPA 2WVXA 3I3BA 1LURA 3T0BA 3E7JA 1K1WA 1EGUA 3MUZ1 1JZ3A 1J0NA 1PX3A 1LF9A 3NJXA 3WVFA 1X1HA 4OZVA 1JZ2A 3I3EA 2ZXQA 1RWFA 3IAQA 1F4HA 3A24A 1HMUA 2HTAA 3T09A 1LXKA 1HMWA 3I3DA 1JOVA 1L7KA 3ECQA 1UG9A 1YQ2A 1F1SA 4D71A 2D73A 2WVYA 2JKAA 2WMGA 1NSUA 1PX4A 2XHNA 1JYWA 2E22A 3OS7A 1ULVA 1N7QA 1JZ7A 1F9GA 1HM3A 2BRVX 4D6EA 1I8QA 2WVXB 2WW1A 1N7NA 1C82A 1Z45A 4BZHA 1K1YA 5E1QA 4D72A 3VSNA 2WZSA 2WW0A 3VDAA 3DCDA 4F10A 2CISA 3OBAA 1W3YA 4D6FA 3MV01 4BZGA 2WMFA 1JZ6A 2BRWA 4BZFA 3NREA 1MMZA 1JZ5A 4NEIA 3NJVA 4D6DA 4D6IA 2JKEA 1OJMA 3MUY1 1HV6A 4OK4A 1JZ8A 3VD9A 1NSSA 3BLCA 4OJZA 4F13A 1RWAA 1NSMA 1LXMA 1NKGA 3OB8A 1N7PA 1JYVA 2HTBA 1NS8A 2WMIA 4D6CA 2JKPA 1NS7A 1TXKA 1YGAA 1OJNA 3TY1A 3DYOA 1MN0A 2WMHA 4D6HA 1MMXA 3E1F1 3WFAA 2CIRA 1NSVA 5A1AA 1LF6A 1NSZA 4OK2A 2WMKA 3T0DA 1CB8A 1NSXA 3T08A 3MWXA 3VDBA 3K25A 4FNVA 4BZEA 1L7JA 2WDAA 2ZQ0A 1RWGA 2FUTA 2WCOA 1F4AA 1N7RA 2WW2A 3AFLA 1OJPA 4D6GA 2E24A 2WMIB 1HN0A 3VD5A 1K1XA 1NS0A 3NFVA 4DUXA 3SEPA 2CIQA 4D6JA 1QAZA 3VD4A 1X1JA 1J0MA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2X03 A;  3DYP A;  2WMJ A;  3CZJ A;  3VSM A;  4MMH A;  3VDC A;  3VD7 A;  3IMH A;  1X1I A;  1RW9 A;  1JYX A;  2WW3 A;  1HM2 A;  2Q1F A;  3Q1N A;  1HN1 A;  5JMD A;  4OZW A;  4RNL A;  1OJO A;  1RWC A;  3VD3 A;  4MMI A;  4DUV A;  1MMY A;  3T2P A;  1RWH A;  3MV1 1;  3BGA A;  4TTG A;  3J7H A;  3IAP A;  1JZ4 A;  3NNB A;  3T2Q A;  1NS4 A;  3DYM A;  1DP0 A;  3DEC A;  4E1Y A;  4DUW A;  2XSG A;  1N7O A;  1SO0 A;  3A0O A;  5JMF A;  2FUQ A;  1NSR A;  2WVZ A;  3T0A A;  1MMU A;  3T2O A;  1SNZ A;  1NS2 A;  4AQ0 A;  1JYN A;  3E80 A;  1LOH A;  2BRP A;  2WVX A;  3I3B A;  1LUR A;  3T0B A;  3E7J A;  1K1W A;  1EGU A;  3MUZ 1;  1JZ3 A;  1J0N A;  1PX3 A;  1LF9 A;  3NJX A;  1X1H A;  4OZV A;  1JZ2 A;  3I3E A;  2ZXQ A;  1RWF A;  3IAQ A;  1F4H A;  3A24 A;  1HMU A;  2HTA A;  3T09 A;  1LXK A;  1HMW A;  3I3D A;  1JOV A;  1L7K A;  3ECQ A;  1UG9 A;  1YQ2 A;  1F1S A;  4D71 A;  2D73 A;  2WVY A;  2JKA A;  2WMG A;  1NSU A;  1PX4 A;  2XHN A;  1JYW A;  2E22 A;  3OS7 A;  1ULV A;  1N7Q A;  1JZ7 A;  1F9G A;  1HM3 A;  2BRV X;  4D6E A;  1I8Q A;  2WVX B;  2WW1 A;  1N7N A;  1C82 A;  1Z45 A;  4BZH A;  1K1Y A;  5E1Q A;  4D72 A;  3VSN A;  2WZS A;  2WW0 A;  3VDA A;  3DCD A;  4F10 A;  2CIS A;  3OBA A;  1W3Y A;  4D6F A;  3MV0 1;  4BZG A;  2WMF A;  1JZ6 A;  2BRW A;  4BZF A;  3NRE A;  1MMZ A;  1JZ5 A;  4NEI A;  3NJV A;  4D6D A;  4D6I A;  2JKE A;  1OJM A;  3MUY 1;  1HV6 A;  4OK4 A;  1JZ8 A;  3VD9 A;  1NSS A;  4OJZ A;  4F13 A;  1RWA A;  1NSM A;  1LXM A;  1NKG A;  3OB8 A;  1N7P A;  1JYV A;  2HTB A;  1NS8 A;  2WMI A;  4D6C A;  2JKP A;  1NS7 A;  1TXK A;  1YGA A;  1OJN A;  3DYO A;  1MN0 A;  2WMH A;  4D6H A;  1MMX A;  3E1F 1;  3WFA A;  2CIR A;  1NSV A;  5A1A A;  1LF6 A;  1NSZ A;  4OK2 A;  2WMK A;  3T0D A;  1CB8 A;  1NSX A;  3T08 A;  3MWX A;  3VDB A;  3K25 A;  4FNV A;  4BZE A;  1L7J A;  2WDA A;  2ZQ0 A;  1RWG A;  2FUT A;  2WCO A;  1F4A A;  1N7R A;  2WW2 A;  3AFL A;  1OJP A;  4D6G A;  2E24 A;  2WMI B;  1HN0 A;  3VD5 A;  1K1X A;  1NS0 A;  3NFV A;  4DUX A;  3SEP A;  2CIQ A;  4D6J A;  1QAZ A;  3VD4 A;  1X1J A;  1J0M A; 
#chains in the Genus database with same CATH topology
 1O6R A;  3CZJ A;  1D8D B;  2WY8 A;  4MMH A;  1H3A A;  3G6J B;  1GXN A;  1RW9 A;  1JYX A;  3Q7A B;  4D4D A;  1L2A A;  1HM2 A;  2A8Z A;  2B4F A;  2E2T A;  1KWF A;  3REN A;  5IL3 A;  1N4S B;  3DST B;  3DX1 A;  3SDQ A;  3W7T A;  1HXK A;  1RWC A;  1QAK A;  1HXA A;  5IM1 A;  3HXF B;  1MMY A;  3LZ9 A;  4Q2B A;  4BOJ A;  1US1 A;  3QDE A;  3T2P A;  1N4P B;  4BTX A;  4TTG A;  2I07 B;  3PZ4 B;  1JCS B;  1JCQ B;  5MEH A;  1IVU A;  3KBT C;  1X81 B;  1NC5 A;  2EAB A;  3GLY A;  3EJP A;  5CD2 A;  1NS4 A;  4J5T A;  3T2Q A;  3K5T A;  1O5M B;  1TF4 A;  3S4C A;  4TF4 A;  3WKI A;  3RX8 A;  4E1Y A;  1DP0 A;  3SXX A;  1G9J A;  1G87 A;  5CZL A;  1N7O A;  2WYN A;  3A0O A;  3RJ3 A;  1H14 A;  1LTX B;  3PZ3 B;  5ILD A;  1JYN A;  3H3K A;  1FBO A;  4EHM B;  1EKM A;  4AYR A;  3D4Z A;  2PN5 A;  3CU7 A;  3E7J A;  1N22 A;  2AHG A;  1JZ3 A;  2OOV C;  4GTS B;  2ALW A;  1LF9 A;  2CFL A;  2BBC A;  3WVF A;  1JZ2 A;  4OZV A;  1FO3 A;  3I3E A;  3W7S A;  1RWF A;  2QNO A;  3K11 A;  1IQY A;  3A24 A;  3X40 A;  3ON6 A;  3RSY A;  1HX9 A;  1HXC A;  1KKT A;  3EJR A;  1TQS A;  4ONT A;  2WVY A;  2DRS A;  1N21 A;  2EAC A;  1HTY A;  2YX9 A;  2OOV A;  1JZ7 A;  1V7W A;  2F7O A;  3S4A A;  1D6Z A;  4GL3 A;  1IQX A;  5M7I A;  4RNQ A;  3G4D A;  1R34 A;  1KSC A;  3KBU C;  5E1Q A;  5JPN B;  2OKX A;  1WMO A;  2OW6 A;  3OBA A;  3QFY A;  4D6F A;  3MV0 1;  5CA3 A;  3BVX A;  4BTY A;  1JZ6 A;  2BB6 A;  5IKH A;  3M73 A;  3K7X A;  2D5J A;  3NRE A;  2DRR A;  1GAH A;  4GTV B;  2RGK A;  2NOJ A;  1JZ8 A;  3DSS B;  4F13 A;  1RWA A;  4D4C A;  1AV4 A;  1AVL A;  4WVB A;  3HI7 A;  5DGR A;  5IK9 A;  3M02 A;  2WOF A;  5ILY A;  3M7L A;  4V1R A;  4D6C A;  2JKP A;  1HXG A;  1TXK A;  1YGA A;  1OJN A;  2WMH A;  1V5D A;  4D6H A;  3DX3 A;  1W4N A;  1AGM A;  2EAE A;  2XN0 A;  1OAC A;  2F1A A;  1H3C A;  1HWW A;  3KSL B;  1N4Q B;  5A1A A;  2CFW A;  3MWX A;  3M75 A;  4FNU A;  2GOX A;  1JS4 A;  1O79 A;  3M00 A;  4AYO A;  3KN4 A;  2WCO A;  2WII B;  1GXO A;  1S64 B;  3M72 A;  2WW2 A;  3HII A;  4D1I A;  3Q73 B;  4DLO A;  1UI8 A;  2WMI B;  3DDG A;  1K1X A;  1TN7 B;  5FOB B;  3SEP A;  3NBJ A;  3E32 B;  4ZRQ A;  4D4B A;  2H6I B;  2F18 A;  1J0M A;  4D1J A;  2F7Q A;  1UT9 A;  3PGB A;  1QQF A;  3EU5 B;  2ZZR A;  2WO0 A;  3D52 A;  3MI6 A;  3VDC A;  3DX0 A;  1XWT A;  3TF4 A;  1X1I A;  2CG0 A;  3HXC B;  1FO2 A;  1GA2 A;  2ZIR B;  3HIG A;  5ILK A;  3M76 A;  1DYU A;  1O1T B;  3Q1N A;  3X41 A;  5FO9 B;  1L1Y A;  1H35 A;  5JMD A;  4OZW A;  4RNL A;  2JF4 A;  5FO7 B;  1NI1 B;  2RI8 A;  3OED A;  4D94 A;  4DOE A;  1H36 A;  4DUV A;  2V3N A;  3E30 B;  1QX1 A;  1RWH A;  1QAF A;  3S4D A;  1GLM A;  2CFG A;  1HZF A;  1XW2 A;  2WYI A;  1RQ5 A;  1O6Q A;  3IAP A;  1JZ4 A;  3VW5 A;  3QRY A;  5IK0 A;  3DYM A;  3F59 A;  4DUW A;  2XSG A;  1SO0 A;  2ZL8 A;  2SQC A;  5JMF A;  5KBP A;  3T0A A;  4D4A A;  2ZBL A;  2BB5 A;  3X3Z A;  5ILJ A;  3SFX B;  3T2O A;  3Q75 B;  1TQT A;  1IU7 A;  1QSJ A;  3BVT A;  2BRP A;  3I3B A;  5ILZ A;  3T0B A;  1LUR A;  5DHK A;  2OQE C;  1K1W A;  2CWT A;  3RX5 A;  1J0N A;  2JG0 A;  3VXD A;  2FBA A;  2CQT A;  3ACT A;  3ACS A;  2WGQ A;  3WKH A;  4ZH5 A;  5M7Y A;  3IAQ A;  3D3I A;  4GTR B;  1FMI A;  5IKA A;  4L9P B;  1F4H A;  2HTA A;  3BUI A;  5EAT A;  5JPM B;  3DPY B;  1LXK A;  4L0G A;  1L7K A;  1UG9 A;  4V1S A;  3N0G A;  4ZH1 A;  2D73 A;  3WIW A;  5ILH A;  2JKA A;  2WOH A;  1W2Z A;  4C1S A;  2XFG A;  1N95 B;  3BUB A;  2XHN A;  2OQE A;  1IVW A;  3P5P A;  3W7U A;  3PQI A;  2Y74 A;  1N94 B;  4DI5 A;  2F1B A;  1F9G A;  2WVX B;  2WW1 A;  1N7N A;  1C82 A;  1Z45 A;  1F9O A;  4BTW A;  2G02 A;  3EUV B;  3VSN A;  3Q78 B;  4KTP A;  4F10 A;  3EU8 A;  3QXF A;  4BZG A;  1CEM A;  4KFD A;  1O1S B;  1N1B A;  3WIR A;  4FXK B;  1MMZ A;  1JZ5 A;  3NJV A;  3ANI A;  4D6D A;  1OJM A;  2XQW A;  5EAU A;  4YDE B;  2G0D A;  1NSS A;  1DCE B;  2CWU A;  3BLC A;  1IVV A;  1KS8 A;  3UD1 A;  3W7W A;  1W6J A;  2HTB A;  2B39 A;  1WU4 A;  1FBW A;  2WMI A;  1GAI A;  1TN6 B;  3MPH A;  2CFK A;  1MN0 A;  4LIX A;  1LF6 A;  1MZC B;  4OK2 A;  3D51 A;  1CB8 A;  1NSX A;  3T08 A;  2FV0 A;  1X9D A;  3VDB A;  1W6C A;  2V8I A;  4BZE A;  1TNU B;  1QAL A;  2AFA A;  1R76 A;  4LNG B;  1TQV A;  2XWB B;  4FJQ A;  3SDV A;  3SAE A;  1QBQ B;  1RWG A;  3OXU A;  1WU5 A;  2XN1 A;  3M7B A;  1H37 A;  2DRQ A;  3PYB A;  4KTR A;  3WUX A;  2YFO A;  2H6G B;  3AFL A;  4KFF A;  3VD5 A;  4Z4J A;  2ONH A;  1TNZ B;  1NS0 A;  4AYP A;  1SA5 B;  4GTM B;  4MU9 A;  1S63 B;  4FNT A;  2YIK A;  3DYP A;  1IA7 A;  3VSM A;  2V8K A;  3VD7 A;  2OW7 A;  5IK6 A;  3S4B A;  2YFN A;  1N4R B;  3CZN A;  3E33 B;  2Q1F A;  1K72 A;  3M71 A;  4K35 A;  3DSW B;  2WY7 A;  1V7V A;  2FV1 A;  3BUQ A;  3VD3 A;  5GY3 A;  1LVN A;  1XWQ A;  3BS6 A;  1N24 A;  2NVP A;  5EAS A;  3EZ8 A;  3U7V A;  2H6F B;  1TQU A;  3BGA A;  2F0Y B;  3MV1 1;  1G9G A;  4ZRP A;  1KFG A;  4K3A A;  3J7H A;  3BVV A;  1H54 A;  3M78 A;  2KXS A;  3LVT A;  1AYX A;  3DEC A;  1N9A B;  4EV5 A;  3NBB A;  2DRO A;  3EQA A;  2FUZ A;  3M77 A;  4GTO B;  2FUQ A;  1NSR A;  2WVZ A;  4UFC A;  3DSU B;  1SIH A;  1H3B A;  1TQW A;  3SX1 A;  3E80 A;  4D8O A;  1LOH A;  2WVX A;  1W5Z A;  1EGU A;  1X1H A;  3D5S A;  3DX4 A;  3WA2 X;  1V5C A;  3AFJ A;  5KKB A;  4L6X A;  3QSP A;  3M74 A;  3M7C A;  3C72 B;  3T09 A;  3PMM A;  1H12 A;  1JCR B;  3I3D A;  2R2L B;  1JOV A;  3ECQ A;  2CQS A;  1YQ2 A;  2CFD A;  1WZZ A;  2J5C A;  2RDY A;  3LOY A;  3HXE B;  4FXG B;  2E22 A;  1W7C A;  3OS7 A;  3GZK A;  1ULV A;  2BT3 A;  1JYW A;  1N7Q A;  2KXR A;  5IL8 A;  1HM3 A;  2BRV X;  4D6E A;  1I8Q A;  1GXM A;  1D6Y A;  1TNO B;  3DX2 A;  3EJT A;  3S9V A;  4BZH A;  4EL8 A;  3W5M A;  3CZS A;  2CG1 A;  4D72 A;  1LD8 B;  4FNS A;  3X42 A;  2WW0 A;  3VDA A;  4DLQ A;  3SDU A;  1W3Y A;  2Z07 A;  2WMF A;  2PMV A;  2BRW A;  4BZF A;  3KLS A;  3ALA A;  2JKE A;  3QT9 A;  3MUY 1;  1HV6 A;  4OK4 A;  4DOD A;  4OJZ A;  2RI9 A;  1SPU A;  2D1W A;  1IA6 A;  1NSM A;  3M7E A;  3OB8 A;  1KZP B;  1N7P A;  2XWJ B;  4LNV A;  5AGD A;  3WKG A;  1JYV A;  1JRQ A;  3KII A;  1WU6 A;  1TU5 A;  1H39 A;  3BUD A;  4WVC A;  3DYO A;  1KRE A;  3TY1 A;  2CIR A;  5GZK A;  1TNY B;  3E34 B;  4LNB B;  3BLB A;  3N9H A;  1IVX A;  4KKJ A;  1SA4 B;  2W0Q A;  3T0D A;  1V7X A;  2ZIS B;  3DDF A;  5ILI A;  4AYQ A;  1KSI A;  3WA3 A;  1VD5 A;  3WIQ A;  3K25 A;  3QWT A;  2CWV A;  3HXB B;  3EJU A;  3ANK A;  3T33 A;  3E6U A;  2ZQ0 A;  2FUT A;  4GTT B;  1FT2 B;  3PYA A;  1LD7 B;  1N7R A;  2H6H B;  3W5N A;  2D8L A;  1R33 A;  1OJP A;  2AHF A;  1HN0 A;  4FUS A;  3W7X A;  3NFV A;  4DUX A;  1FP3 A;  1O6H A;  4D6J A;  1QAZ A;  2X03 A;  3WC3 A;  1HCU A;  2WMJ A;  3CIH A;  4FNR A;  4WVA A;  2Y73 A;  1C3D A;  1KSD A;  3IMH A;  3RRS A;  3Q7F B;  4CJ0 A;  2WW3 A;  2V8J A;  1QWU A;  4FNQ A;  3AMO B;  4ZG8 A;  3BVU A;  1PS3 A;  3QFZ A;  1HN1 A;  1OJO A;  5GW7 A;  3CV5 A;  3M01 A;  3Q79 B;  2PNC A;  4MMI A;  1D6U A;  1N9E A;  5C05 A;  1GHQ A;  2A73 B;  1RJO A;  4GAX A;  4XUV A;  2WYH A;  1A2V A;  1CLC A;  2XN2 A;  4BOK A;  3NNB A;  1IS9 A;  1DL2 A;  3QG0 A;  3A3V A;  2IEJ B;  1NXC A;  3DSV B;  4KKI A;  3EJS A;  1MMU A;  4EV2 A;  1SNZ A;  1W6G A;  1TNB B;  1NS2 A;  4AQ0 A;  2C10 A;  4YDO B;  3H7L A;  2F7R A;  1UI7 A;  4Z4L A;  4M76 A;  1KRF A;  1WMP A;  3MUZ 1;  5E2J A;  1PX3 A;  3PZ1 B;  3NJX A;  4QT9 A;  4JJJ A;  1F9D A;  2ZXQ A;  3GT5 A;  3X3Y A;  1W6K A;  1HMU A;  1UMP A;  2ONG A;  3DSX B;  2GH4 A;  1HMW A;  3RX7 A;  5FO8 B;  2F7P A;  3SQC A;  2F6D A;  3BVW A;  1F1S A;  1GSZ A;  1TN8 B;  4D71 A;  2FYV A;  3SDR A;  1FT1 B;  2C11 A;  2WMG A;  2EAD A;  3DRA B;  3QT3 A;  1NSU A;  1PX4 A;  1DOG A;  1WMN A;  3QR8 A;  2VN4 A;  3KSQ B;  3PZ2 B;  3D5R A;  1G6I A;  2VN7 A;  4MBG B;  1D8E B;  3D4Y A;  1K1Y A;  4YCR A;  1SII A;  3G4F A;  1QWN A;  3D50 A;  2WZS A;  3BUP A;  2JJB A;  3DCD A;  3EJQ A;  1RKY A;  2CIS A;  1AVK A;  1N23 A;  3P5R A;  4CE7 A;  4Q88 A;  1SQC A;  4NEI A;  1KZO B;  4D6I A;  3VD9 A;  3X17 A;  3UD2 A;  4GTP B;  3X3X A;  1LXM A;  1NKG A;  1FAE A;  3SFY B;  1NS8 A;  3QXQ A;  3HXD B;  1NS7 A;  1N1Z A;  3SDT A;  3E37 B;  1FPP B;  3E73 A;  2P0V A;  1MMX A;  1NSV A;  1N20 A;  3E1F 1;  3WFA A;  3ANJ A;  1NSZ A;  1O7D D;  4FNP A;  2WMK A;  3T0U A;  4WU0 A;  1NL4 B;  1FCE A;  1O1R B;  4FNV A;  1PU4 A;  3H2W A;  3P2C A;  1L7J A;  5DGQ A;  4GTQ B;  1H13 A;  2WDA A;  3QPF A;  2E2U A;  3AMO A;  2WIN B;  1F4A A;  4TXT A;  4CJ1 A;  2BED B;  2E2V A;  2V3P A;  4D6G A;  2E24 A;  2GZ6 A;  3N0F A;  3WKF A;  5DHI A;  2CIQ A;  4KFE A;  3KQ4 A;  3VD4 A;  1X1J A; 
#chains in the Genus database with same CATH homology
 2X03 A;  3DYP A;  2WMJ A;  3CZJ A;  3VSM A;  4MMH A;  3VDC A;  3VD7 A;  3IMH A;  1X1I A;  1RW9 A;  1JYX A;  2WW3 A;  1HM2 A;  2Q1F A;  3Q1N A;  1HN1 A;  5JMD A;  4OZW A;  4RNL A;  1OJO A;  1RWC A;  3VD3 A;  4MMI A;  4DUV A;  1MMY A;  3BS6 A;  3T2P A;  1RWH A;  3MV1 1;  3BGA A;  4TTG A;  3J7H A;  3IAP A;  1JZ4 A;  3NNB A;  3T2Q A;  1NS4 A;  4J5T A;  3DYM A;  1DP0 A;  3DEC A;  4E1Y A;  4DUW A;  2XSG A;  1N7O A;  1SO0 A;  3A0O A;  5JMF A;  2FUQ A;  1NSR A;  2WVZ A;  3T0A A;  1MMU A;  3T2O A;  1SNZ A;  1NS2 A;  4AQ0 A;  1JYN A;  3E80 A;  1LOH A;  2BRP A;  2WVX A;  3I3B A;  1LUR A;  3T0B A;  3E7J A;  1K1W A;  1EGU A;  3MUZ 1;  1JZ3 A;  1J0N A;  1PX3 A;  1LF9 A;  3NJX A;  3WVF A;  1X1H A;  4OZV A;  1JZ2 A;  3I3E A;  2ZXQ A;  1RWF A;  3IAQ A;  1F4H A;  3A24 A;  1HMU A;  2HTA A;  3T09 A;  1LXK A;  1HMW A;  3I3D A;  1JOV A;  1L7K A;  3ECQ A;  1UG9 A;  1YQ2 A;  1F1S A;  4D71 A;  2D73 A;  2WVY A;  2JKA A;  2WMG A;  1NSU A;  1PX4 A;  2XHN A;  1JYW A;  2E22 A;  3OS7 A;  1ULV A;  1N7Q A;  1JZ7 A;  1F9G A;  1HM3 A;  2BRV X;  4D6E A;  1I8Q A;  2WVX B;  2WW1 A;  1N7N A;  1C82 A;  1Z45 A;  4BZH A;  1K1Y A;  5E1Q A;  4D72 A;  3VSN A;  2WZS A;  2WW0 A;  3VDA A;  3DCD A;  4F10 A;  2CIS A;  3OBA A;  1W3Y A;  4D6F A;  3MV0 1;  4BZG A;  2WMF A;  1JZ6 A;  2BRW A;  4BZF A;  3NRE A;  1MMZ A;  1JZ5 A;  4NEI A;  3NJV A;  4D6D A;  4D6I A;  2JKE A;  1OJM A;  3MUY 1;  1HV6 A;  4OK4 A;  1JZ8 A;  3VD9 A;  1NSS A;  3BLC A;  4OJZ A;  4F13 A;  1RWA A;  1NSM A;  1LXM A;  1NKG A;  3OB8 A;  1N7P A;  1JYV A;  2HTB A;  1NS8 A;  2WMI A;  4D6C A;  2JKP A;  1NS7 A;  1TXK A;  1YGA A;  1OJN A;  3TY1 A;  3DYO A;  1MN0 A;  2WMH A;  4D6H A;  1MMX A;  3E1F 1;  3WFA A;  2CIR A;  1NSV A;  5A1A A;  1LF6 A;  1NSZ A;  4OK2 A;  2WMK A;  3T0D A;  1CB8 A;  1NSX A;  3T08 A;  3MWX A;  3VDB A;  3K25 A;  4FNV A;  4BZE A;  1L7J A;  2WDA A;  2ZQ0 A;  1RWG A;  2FUT A;  2WCO A;  1F4A A;  1N7R A;  2WW2 A;  3AFL A;  1OJP A;  4D6G A;  2E24 A;  2WMI B;  1HN0 A;  3VD5 A;  1K1X A;  1NS0 A;  3NFV A;  4DUX A;  3SEP A;  2CIQ A;  4D6J A;  1QAZ A;  3VD4 A;  1X1J A;  1J0M A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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