1HMUA

Active site of chondroitinase ac lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis
Total Genus 244
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
244
sequence length
674
structure length
674
Chain Sequence
GTAELIMKRVMLDLKKPLRNMDKVAEKNLNTLQPDGSWKDVPYKDDAMTNWLPNNHLLQLETIIQAYIEKDSHYYGDDKVFDQISKAFKYWYDSDPKSRNWWHNEIATPQALGEMLILMRYGKKPLDEALVHKLTERMKRGEPEKKTGANKTDIALHYFYRALLTSDEALLSFAVKELFYPVQFVHYEEGLQYDYSYLQHGPQLQISSYGAVFITGVLKLANYVRDTPYALSTEKLAIFSKYYRDSYLKAIRGSYMDFNVEGRGVSRPDILNKKAEKKRLLVAKMIDLKHTEEWADAIARTDSTVAAGYKIEPYHHQFWNGDYVQHLRPAYSFNVRMVSKRTRRSESGNKENLLGRYLSDGATNIQLRGPEYYNIMPVWEWDKIPGITSRDYLTDRPLTKLWGEQGSNDFAGGVSDGVYGASAYALDYDSLQAKKAWFFFDKEIVCLGAGINSNAPENITTTLNQSWLNGPVISTAGKTGRGKITTFKAQGQFWLLHDAIGYYFPEGANLSLSTQSQKGNWFHINNSHSKDEVSGDVFKLWINHGARPENAQYAYIVLPGINKPEEIKKYNGTAPKVLANTNQLQAVYHQQLDMVQAIFYTAGKLSVAGIEIETDKPCAVLIKHINGKQVIWAADPLQKEKTAVLSIRDLKTGKTNRVKIDFPQQEFAGATVEL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords CHONDROITINASE AC
publication title Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis.
pubmed doi rcsb
source organism Pedobacter heparinus
molecule tags Lyase
total genus 244
structure length 674
sequence length 674
ec nomenclature ec 4.2.2.5: Chondroitin AC lyase.
pdb deposition date 2000-12-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02278 Lyase_8 Polysaccharide lyase family 8, super-sandwich domain
A PF02884 Lyase_8_C Polysaccharide lyase family 8, C-terminal beta-sandwich domain
A PF08124 Lyase_8_N Polysaccharide lyase family 8, N terminal alpha-helical domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.50.10.100 Mainly Alpha Alpha/alpha barrel Glycosyltransferase Chondroitin AC/alginate lyase 1hmuA01
2.60.220.10 Mainly Beta Sandwich Chondroitinase Ac; Chain A, domain 3 Polysaccharide lyase family 8-like, C-terminal 1hmuA03
2.70.98.10 Mainly Beta Distorted Sandwich Beta-galactosidase; Chain A, domain 5 Beta-galactosidase; Chain A, domain 5 1hmuA02
2WMIA 1NSSA 4D71A 1X1HA 2BRWA 1LOHA 1YQ2A 4OZWA 2WMHA 1LXKA 1N7OA 4OZVA 1X1JA 1NSZA 3VD5A 4D6GA 3BGAA 1QAZA 1HM2A 2CIQA 4OK2A 1HN0A 1F4HA 1N7RA 3AFLA 4D6HA 1SNZA 1NSMA 1JYXA 3VDAA 1RW9A 1NS8A 4D72A 2Q1FA 1DP0A 4DUXA 3DYMA 3I3EA 1HN1A 2X03A 5E1QA 2WVYA 2BRVX 1NKGA 1UG9A 2FUTA 1PX4A 1JZ2A 3NNBA 1HMWA 2WW2A 3T08A 3A0OA 1EGUA 1SO0A 2WDAA 1YGAA 3Q1NA 2WMIB 3VSMA 2WW1A 3IAQA 4BZHA 4D6FA 3OB8A 3VD7A 2ZQ0A 3VD3A 1JZ3A 3OS7A 1RWFA 2JKPA 3MUZ1 4D6JA 3WFAA 4DUVA 4DUWA 4D6DA 1K1XA 1NSRA 4F13A 1MMUA 2XHNA 5JMFA 3T0DA 2WVXA 3MUY1 1HM3A 1NS2A 3K25A 1OJMA 1RWAA 3A24A 1F1SA 3T2QA 5A1AA 4FNVA 2JKAA 1I8QA 1F4AA 2HTBA 1MMXA 1HV6A 2WW0A 1OJPA 2WVZA 3E1F1 3VD9A 2WMJA 1CB8A 1NS0A 3MWXA 3SEPA 1OJNA 3VDBA 1RWHA 1L7KA 2FUQA 4MMIA 4OJZA 1ULVA 4BZFA 3T0AA 3T0BA 4BZEA 3DECA 1TXKA 1LF6A 1X1IA 4D6IA 2WMFA 1J0MA 3VSNA 1K1WA 3T2PA 3VD4A 5JMDA 2HTAA 1K1YA 1C82A 2WVXB 1JZ5A 2E24A 1JOVA 1JZ8A 1RWGA 2JKEA 1JYNA 1W3YA 2WMGA 1J0NA 1L7JA 1NSUA 3CZJA 3OBAA 4BZGA 1N7PA 1LXMA 4NEIA 4F10A 1JYVA 1MN0A 1MMZA 1NS4A 4TTGA 1NS7A 3I3DA 4AQ0A 1JZ6A 3ECQA 1RWCA 4E1YA 1Z45A 2WCOA 2XSGA 3E80A 1NSXA 1N7QA 3MV11 2D73A 1F9GA 1LF9A 3DCDA 2BRPA 2CIRA 3T09A 3I3BA 1LURA 3E7JA 3DYOA 4D6CA 2CISA 3NJXA 1JZ4A 1N7NA 1NSVA 3IMHA 1PX3A 2WMKA 3IAPA 4RNLA 1JYWA 4MMHA 1MMYA 3NREA 1JZ7A 3J7HA 4D6EA 1OJOA 3VDCA 1HMUA 2WW3A 4OK4A 2ZXQA 3NJVA 3MV01 3DYPA 3T2OA 3NFVA 2WZSA 2E22A
chains in the Genus database with same CATH superfamily
3P5RA 5FO9B 3QPFA 5EAUA 5DGRA 3RENA 4OZWA 1X9DA 3AMOB 3EJQA 2WINB 4OZVA 3QT3A 3K11A 2WGQA 1NSZA 5GZKA 3DSVB 1HM2A 2CIQA 4GTPB 2WY8A 1UT9A 2ZZRA 1GXMA 4FNPA 1KSCA 1RW9A 3T0UA 1D8DB 1N22A 3E32B 4DLOA 1RJOA 3BUIA 2ZISB 3DYMA 4GTTB 3S4DA 3EQAA 1UMPA 3A3VA 3ACTA 2P0VA 2BRVX 1JZ2A 3E73A 3G4DA 1HWWA 1TF4A 1EGUA 2RGKA 4AYPA 2WDAA 1YGAA 3ACSA 3RRSA 5IL8A 2CWVA 3BVUA 3VD7A 4D4BA 4LNBB 1L2AA 2ZL8A 1N21A 4EHMB 3DX2A 3HIGA 2ONGA 1F9OA 4D6DA 1UI7A 1A2VA 2PN5A 2F0YB 3BUDA 3T0DA 3OXUA 4L9PB 2YIKA 3BUBA 4D1IA 2CQTA 3PMMA 3DRAB 4LNGB 3A24A 1FO3A 1F1SA 1QWUA 2HTBA 1MMXA 4D1JA 1WMNA 1O6RA 3VD9A 2V3PA 3BVTA 1XWTA 2OQEA 4YDEB 1KS8A 1KREA 3M7BA 5CD2A 3EU5B 3KBTC 1OJNA 1N95B 4XUVA 1FBOA 2FUQA 1G9GA 3F59A 3ANJA 1N4PB 1TXKA 4BTWA 1X1IA 5CZLA 2WMFA 1J0MA 3VD4A 4WVCA 3VXDA 3RX5A 3E6UA 5GY3A 3QG0A 2WVXB 3CV5A 1RWGA 2XWBB 2JKEA 2WMGA 1L7JA 1N7PA 1RKYA 4NEIA 2NOJA 1MN0A 1NS4A 3ANIA 4ZRPA 1W5ZA 5IKAA 2WYNA 4FJQA 2KXRA 3BUPA 2V8JA 1L1YA 3SDUA 1IVUA 1IA7A 2WCOA 3DPYB 2E2VA 3E80A 2RI8A 1KSIA 1N7QA 1F9GA 2AFAA 2BRPA 3HXFB 3I3BA 3E37B 1JCSB 3K7XA 4Q2BA 3PYAA 3QSPA 1N7NA 4ONTA 1NL4B 1DOGA 3CU7A 2WMKA 3QXFA 4RNLA 1WU4A 1JZ7A 3KLSA 4RNQA 2H6GB 3W5NA 1UI8A 1DCEB 4EL8A 4BTYA 3NJVA 4OK4A 3SFXB 3D51A 1HXAA 1AGMA 3Q78B 5ILZA 4BOKA 2WZSA 1GAIA 2WMIA 2WO0A 1X1HA 1SA4B 3EJSA 1FBWA 1TQUA 1LXKA 1N4QB 1H3CA 1HXGA 3VD5A 3BS6A 1QAZA 2FYVA 3WVFA 3HXEB 1HN0A 3QFYA 3EJUA 1GXOA 1NSMA 1JYXA 3VDAA 3X3XA 2F7OA 3M73A 1D6ZA 1NS8A 3DX3A 1HTYA 4TXTA 2Q1FA 3KSQB 3SAEA 2OW6A 3I3EA 5ILJA 3M7LA 4DOEA 4V1RA 1JCRB 1W6CA 1HCUA 3D5SA 2WVYA 2WIIB 2B4FA 4ZG8A 1AVLA 5GW7A 2FUTA 2XFGA 3HIIA 2GZ6A 5DGQA 1IQYA 2ALWA 1IA6A 2CFKA 3Q1NA 1V7WA 4CJ0A 3RX8A 2FBAA 5IK9A 3PQIA 1IVXA 2VN7A 4WVAA 4D6FA 3WA2X 4AYQA 3NBJA 2E2UA 1TNUB 4GTVB 1GA2A 1RWFA 3D4YA 2F1AA 1N1ZA 3QWTA 4LNVA 1NSRA 3WIQA 3HXDB 2XWJB 2XHNA 3Q7FB 2WYIA 5DHKA 4ZH1A 3HI7A 3WIWA 1TNOB 3MUY1 3DSSB 2FV0A 1AV4A 3GLYA 3MI6A 4V1SA 1OJMA 2J5CA 2DRSA 3W5MA 2WY7A 1JCQB 3PZ2B 1I8QA 2SQCA 1F4AA 2QNOA 2WW0A 1OJPA 1S63B 3M71A 3WIRA 1O6HA 3W7UA 2WMJA 2BT3A 2CG1A 1N4SB 1TQTA 1G87A 4D4CA 4EV5A 4CJ1A 3VDBA 1FO2A 4FNQA 3TF4A 1L7KA 1JS4A 4MMIA 3T33A 3D50A 5ILKA 4GL3A 4BZFA 1KKTA 5ILIA 2JG0A 3T2PA 3VSNA 1KZPB 2A73B 5ILHA 4CE7A 2D5JA 3DSTB 4Z4JA 1K1YA 1C82A 2WOFA 3QFZA 1JYNA 1W3YA 3EZ8A 3LOYA 1QAFA 3CZJA 4TTGA 1VD5A 3U7VA 1MMZA 2OOVC 3W7WA 1NS7A 1H35A 3I3DA 1R34A 2BB6A 1H12A 1H36A 2FUZA 4E1YA 1V7XA 2OW7A 4L6XA 1W6GA 3GZKA 2CIRA 3KSLB 1DYUA 4LIXA 2CISA 3M76A 3K5TA 1PX3A 3IAPA 1AVKA 1TQVA 1LTXB 4D94A 1V5DA 2F1BA 2V3NA 3X3YA 2XQWA 2AHGA 1OJOA 2DRRA 3LVTA 1HMUA 1KRFA 3Q73B 3UD2A 3KIIA 3PZ1B 3M77A 4JJJA 3DDGA 4Q88A 3Q75B 2Y73A 4KFDA 3SDRA 4J5TA 5C05A 3QRYA 4MBGB 4D71A 1NSSA 1LOHA 1YQ2A 1FT2B 3BLBA 3X3ZA 1LD8B 5CA3A 3EJPA 1HZFA 1X1JA 4ZH5A 1GSZA 3CZSA 4OK2A 3X40A 1O6QA 3PZ4B 1XWQA 1F4HA 2E2TA 1SNZA 4D6HA 4FNUA 2CG0A 3E30B 1US1A 4D72A 1DP0A 1N9EA 1KZOB 5JPMB 1FAEA 3Q79B 2X03A 1O7DD 1CLCA 1H39A 4WVBA 1UG9A 1PX4A 3NNBA 3DX0A 1X81B 4Z4LA 1SO0A 1TN6B 3CZNA 1OACA 3E34B 3TY1A 2WMIB 3P2CA 4KTPA 3VSMA 2WW1A 3IAQA 4KFFA 3OB8A 1TNZB 3HXCB 5EATA 2ZQ0A 3VD3A 3OS7A 2JKPA 4TF4A 4D6JA 3WFAA 2JJBA 1FMIA 2A8ZA 4KKJA 5E2JA 1K1XA 1H13A 3H7LA 3AFJA 3RJ3A 1TN8B 2CWUA 3DDFA 4D4DA 5JMFA 4YCRA 3OEDA 2OOVA 1S64B 1KSDA 1XW2A 5FOBB 2ZBLA 1QX1A 3K25A 3N0GA 3CIHA 1DL2A 3W7TA 1R33A 3M75A 1RWAA 1GXNA 1QWNA 1W2ZA 4QT9A 3N9HA 4FNVA 2VN4A 2JKAA 1N1BA 1V7VA 2CFGA 4FUSA 2ONHA 3KBUC 3BVXA 1HV6A 2F7RA 3RSYA 3NBBA 4WU0A 2CFDA 2WVZA 3E1F1 2BEDB 2YFOA 1CB8A 3M72A 4DI5A 3ANKA 3DSXB 1NS0A 2EABA 4FNRA 2F18A 3M7CA 1IVVA 3SEPA 1AYXA 1NXCA 1RWHA 4UFCA 1IQXA 3QT9A 4OJZA 2WOHA 3T0AA 4K35A 2CFWA 3DECA 2PMVA 3X17A 1K1WA 5JMDA 1WMOA 1O1TB 2D1WA 3EJRA 4GTQB 2I07B 2E24A 5JPNB 1KWFA 1NSUA 4BZGA 3M02A 2BB5A 3EJTA 1HXKA 2JF4A 3M74A 4L0GA 1LVNA 3RX7A 4GTRB 1JZ6A 3HXBB 2YFNA 1D6UA 3QXQA 3SDQA 5IK0A 1EKMA 3PZ3B 1PS3A 2NVPA 3QR8A 3AMOA 4GTMB 3MPHA 3MV11 2D73A 3DCDA 1WU6A 3BUQA 5ILDA 3S4BA 1D8EB 4GTOB 3E7JA 2Z07A 1SIIA 4D6CA 1R76A 3D4ZA 3DYOA 3PGBA 4FNTA 2R2LB 3S4AA 1O79A 5EASA 2XN1A 1H37A 5DHIA 1TN7B 3Q7AB 4BOJA 1JYWA 1SQCA 1QAKA 3KQ4A 1H54A 4DLQA 2C10A 3J7HA 3VDCA 2B39A 3M00A 1D6YA 1JRQA 2Y74A 2EADA 3BVVA 1QQFA 1O5MB 3M01A 2AHFA 3WKHA 3MV01 4D4AA 3DYPA 3T2OA 2ZIRB 1H14A 2DROA 3WKFA 2E22A 2RI9A 1TQSA 3D3IA 2BRWA 5KBPA 2XN0A 1N94B 1H3BA 2WMHA 1N7OA 3WUXA 2G02A 2RDYA 3DSWB 4M76A 4D6GA 3BGAA 2FV1A 1SA5B 1N7RA 3AFLA 3SXXA 2CWTA 1N24A 1IVWA 3H3KA 1LD7B 3DX4A 4DUXA 1RQ5A 1TNBB 3DX1A 1HN1A 1N9AB 5E1QA 1NKGA 1FT1B 1O1RB 5IK6A 3PYBA 2GH4A 5FO8B 1HMWA 1QSJA 1W7CA 2WW2A 3T08A 3A0OA 1SIHA 2OKXA 1N4RB 2D8LA 2YX9A 1IS9A 4FXGB 4DODA 1WU5A 3X41A 3G4FA 1F9DA 4EV2A 4BZHA 3M7EA 3UD1A 2CQSA 1JZ3A 1HX9A 3G6JB 1HXCA 3ALAA 3MUZ1 4DUVA 4K3AA 4DUWA 4FXKB 4BTXA 2H6FB 4ZRQA 1NC5A 4F13A 3C72B 1MMUA 2KXSA 1N23A 3SQCA 1H3AA 2WVXA 1HM3A 1FCEA 3S9VA 1NS2A 3SFYB 2WYHA 1TQWA 5KKBA 3T2QA 2G0DA 5IL3A 2XN2A 1NI1B 4AYRA 3WA3A 1QBQB 1WMPA 3MWXA 1TU5A 4AYOA 5ILYA 2F7QA 1PU4A 2BBCA 2H6HB 3GT5A 3EU8A 1ULVA 1O1SB 1IU7A 4GAXA 3T0BA 2EACA 2GOXA 4BZEA 1LF6A 4MU9A 2H6IB 4D6IA 4C1SA 3H2WA 1CEMA 3SX1A 2HTAA 3W7XA 3EUVB 1JZ8A 1JZ5A 1WZZA 1JOVA 3D52A 1FPPB 1J0NA 1KFGA 1GLMA 2F6DA 1GHQA 2IEJB 1LXMA 1C3DA 3N0FA 3VW5A 4F10A 3OBAA 1G6IA 1JYVA 1QALA 4KFEA 1TNYB 1MZCB 4YDOB 3P5PA 1FP3A 3M78A 4AQ0A 5IKHA 3S4CA 3WKIA 3ECQA 1RWCA 2C11A 3WKGA 3DSUB 1Z45A 3QDEA 4GTSB 4KKIA 2XSGA 1NSXA 3BLCA 3E33B 2F7PA 1LF9A 2EAEA 1N20A 5IM1A 2OQEC 3T09A 1LURA 3WC3A 3NJXA 5A1AA 1JZ4A 5MEHA 2PNCA 2W0QA 3LZ9A 3BVWA 1NSVA 1W4NA 3IMHA 2CFLA 1W6JA 3D5RA 4KTRA 5AGDA 4MMHA 3KN4A 2V8IA 1MMYA 3NREA 3ON6A 4D6EA 5M7IA 3X42A 1W6KA 5FO7B 2DRQA 3SDVA 1GAHA 1V5CA 4FNSA 2WW3A 2V8KA 2ZXQA 1G9JA 4D8OA 3NFVA 1SPUA 3SDTA 3W7SA 1K72A 5M7YA
chains in the Genus database with same CATH topology
2WMIA 1NSSA 4D71A 1X1HA 2BRWA 4J5TA 1LOHA 1YQ2A 4OZWA 2WMHA 1LXKA 1N7OA 4OZVA 1X1JA 1NSZA 3VD5A 3BS6A 4D6GA 3BGAA 1QAZA 3WVFA 1HM2A 2CIQA 4OK2A 1HN0A 1F4HA 1N7RA 3AFLA 4D6HA 1SNZA 1NSMA 1JYXA 3VDAA 1RW9A 1NS8A 4D72A 2Q1FA 1DP0A 4DUXA 3DYMA 3I3EA 1HN1A 2X03A 5E1QA 2WVYA 2BRVX 1NKGA 1UG9A 2FUTA 1PX4A 1JZ2A 3NNBA 1HMWA 2WW2A 3T08A 3A0OA 1EGUA 1SO0A 2WDAA 1YGAA 3Q1NA 3TY1A 2WMIB 3VSMA 2WW1A 3IAQA 4BZHA 4D6FA 3OB8A 3VD7A 2ZQ0A 3VD3A 1JZ3A 3OS7A 1RWFA 2JKPA 3MUZ1 4D6JA 3WFAA 4DUVA 4DUWA 4D6DA 1K1XA 1NSRA 4F13A 1MMUA 2XHNA 5JMFA 3T0DA 2WVXA 3MUY1 1HM3A 1NS2A 3K25A 1OJMA 1RWAA 3A24A 1F1SA 3T2QA 5A1AA 4FNVA 2JKAA 1I8QA 1F4AA 2HTBA 1MMXA 1HV6A 2WW0A 1OJPA 2WVZA 3E1F1 3VD9A 2WMJA 1CB8A 1NS0A 3MWXA 3SEPA 1OJNA 3VDBA 1RWHA 1L7KA 2FUQA 4MMIA 4OJZA 1ULVA 4BZFA 3T0AA 3T0BA 4BZEA 3DECA 1TXKA 1LF6A 1X1IA 4D6IA 2WMFA 1J0MA 3VSNA 1K1WA 3T2PA 3VD4A 5JMDA 2HTAA 1K1YA 1C82A 2WVXB 1JZ5A 2E24A 1JOVA 1JZ8A 1RWGA 2JKEA 1JYNA 1W3YA 2WMGA 1J0NA 1L7JA 1NSUA 3CZJA 3OBAA 4BZGA 1N7PA 1LXMA 4NEIA 4F10A 1JYVA 1MN0A 1MMZA 1NS4A 4TTGA 1NS7A 3I3DA 4AQ0A 1JZ6A 3ECQA 1RWCA 4E1YA 1Z45A 2WCOA 2XSGA 3E80A 1NSXA 3BLCA 1N7QA 3MV11 2D73A 1F9GA 1LF9A 3DCDA 2BRPA 2CIRA 3T09A 3I3BA 1LURA 3E7JA 3DYOA 4D6CA 2CISA 3NJXA 1JZ4A 1N7NA 1NSVA 3IMHA 1PX3A 2WMKA 3IAPA 4RNLA 1JYWA 4MMHA 1MMYA 3NREA 1JZ7A 3J7HA 4D6EA 1OJOA 3VDCA 1HMUA 2WW3A 4OK4A 2ZXQA 3NJVA 3MV01 3DYPA 3T2OA 3NFVA 2WZSA 2E22A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WMI A;  1NSS A;  4D71 A;  1X1H A;  2BRW A;  1LOH A;  1YQ2 A;  4OZW A;  2WMH A;  1LXK A;  1N7O A;  4OZV A;  1X1J A;  1NSZ A;  3VD5 A;  4D6G A;  3BGA A;  1QAZ A;  1HM2 A;  2CIQ A;  4OK2 A;  1HN0 A;  1F4H A;  1N7R A;  3AFL A;  4D6H A;  1SNZ A;  1NSM A;  1JYX A;  3VDA A;  1RW9 A;  1NS8 A;  4D72 A;  2Q1F A;  1DP0 A;  4DUX A;  3DYM A;  3I3E A;  1HN1 A;  2X03 A;  5E1Q A;  2WVY A;  2BRV X;  1NKG A;  1UG9 A;  2FUT A;  1PX4 A;  1JZ2 A;  3NNB A;  1HMW A;  2WW2 A;  3T08 A;  3A0O A;  1EGU A;  1SO0 A;  2WDA A;  1YGA A;  3Q1N A;  2WMI B;  3VSM A;  2WW1 A;  3IAQ A;  4BZH A;  4D6F A;  3OB8 A;  3VD7 A;  2ZQ0 A;  3VD3 A;  1JZ3 A;  3OS7 A;  1RWF A;  2JKP A;  3MUZ 1;  4D6J A;  3WFA A;  4DUV A;  4DUW A;  4D6D A;  1K1X A;  1NSR A;  4F13 A;  1MMU A;  2XHN A;  5JMF A;  3T0D A;  2WVX A;  3MUY 1;  1HM3 A;  1NS2 A;  3K25 A;  1OJM A;  1RWA A;  3A24 A;  1F1S A;  3T2Q A;  5A1A A;  4FNV A;  2JKA A;  1I8Q A;  1F4A A;  2HTB A;  1MMX A;  1HV6 A;  2WW0 A;  1OJP A;  2WVZ A;  3E1F 1;  3VD9 A;  2WMJ A;  1CB8 A;  1NS0 A;  3MWX A;  3SEP A;  1OJN A;  3VDB A;  1RWH A;  1L7K A;  2FUQ A;  4MMI A;  4OJZ A;  1ULV A;  4BZF A;  3T0A A;  3T0B A;  4BZE A;  3DEC A;  1TXK A;  1LF6 A;  1X1I A;  4D6I A;  2WMF A;  1J0M A;  3VSN A;  1K1W A;  3T2P A;  3VD4 A;  5JMD A;  2HTA A;  1K1Y A;  1C82 A;  2WVX B;  1JZ5 A;  2E24 A;  1JOV A;  1JZ8 A;  1RWG A;  2JKE A;  1JYN A;  1W3Y A;  2WMG A;  1J0N A;  1L7J A;  1NSU A;  3CZJ A;  3OBA A;  4BZG A;  1N7P A;  1LXM A;  4NEI A;  4F10 A;  1JYV A;  1MN0 A;  1MMZ A;  1NS4 A;  4TTG A;  1NS7 A;  3I3D A;  4AQ0 A;  1JZ6 A;  3ECQ A;  1RWC A;  4E1Y A;  1Z45 A;  2WCO A;  2XSG A;  3E80 A;  1NSX A;  1N7Q A;  3MV1 1;  2D73 A;  1F9G A;  1LF9 A;  3DCD A;  2BRP A;  2CIR A;  3T09 A;  3I3B A;  1LUR A;  3E7J A;  3DYO A;  4D6C A;  2CIS A;  3NJX A;  1JZ4 A;  1N7N A;  1NSV A;  3IMH A;  1PX3 A;  2WMK A;  3IAP A;  4RNL A;  1JYW A;  4MMH A;  1MMY A;  3NRE A;  1JZ7 A;  3J7H A;  4D6E A;  1OJO A;  3VDC A;  1HMU A;  2WW3 A;  4OK4 A;  2ZXQ A;  3NJV A;  3MV0 1;  3DYP A;  3T2O A;  3NFV A;  2WZS A;  2E22 A; 
#chains in the Genus database with same CATH topology
 3P5R A;  5FO9 B;  3QPF A;  5EAU A;  5DGR A;  3REN A;  4OZW A;  1X9D A;  3AMO B;  3EJQ A;  2WIN B;  4OZV A;  3QT3 A;  3K11 A;  2WGQ A;  1NSZ A;  5GZK A;  3DSV B;  1HM2 A;  2CIQ A;  4GTP B;  2WY8 A;  1UT9 A;  2ZZR A;  1GXM A;  4FNP A;  1KSC A;  1RW9 A;  3T0U A;  1D8D B;  1N22 A;  3E32 B;  4DLO A;  1RJO A;  3BUI A;  2ZIS B;  3DYM A;  4GTT B;  3S4D A;  3EQA A;  1UMP A;  3A3V A;  3ACT A;  2P0V A;  2BRV X;  1JZ2 A;  3E73 A;  3G4D A;  1HWW A;  1TF4 A;  1EGU A;  2RGK A;  4AYP A;  2WDA A;  1YGA A;  3ACS A;  3RRS A;  5IL8 A;  2CWV A;  3BVU A;  3VD7 A;  4D4B A;  4LNB B;  1L2A A;  2ZL8 A;  1N21 A;  4EHM B;  3DX2 A;  3HIG A;  2ONG A;  1F9O A;  4D6D A;  1UI7 A;  1A2V A;  2PN5 A;  2F0Y B;  3BUD A;  3T0D A;  3OXU A;  4L9P B;  2YIK A;  3BUB A;  4D1I A;  2CQT A;  3PMM A;  3DRA B;  4LNG B;  3A24 A;  1FO3 A;  1F1S A;  1QWU A;  2HTB A;  1MMX A;  4D1J A;  1WMN A;  1O6R A;  3VD9 A;  2V3P A;  3BVT A;  1XWT A;  2OQE A;  4YDE B;  1KS8 A;  1KRE A;  3M7B A;  5CD2 A;  3EU5 B;  3KBT C;  1OJN A;  1N95 B;  4XUV A;  1FBO A;  2FUQ A;  1G9G A;  3F59 A;  3ANJ A;  1N4P B;  1TXK A;  4BTW A;  1X1I A;  5CZL A;  2WMF A;  1J0M A;  3VD4 A;  4WVC A;  3VXD A;  3RX5 A;  3E6U A;  5GY3 A;  3QG0 A;  2WVX B;  3CV5 A;  1RWG A;  2XWB B;  2JKE A;  2WMG A;  1L7J A;  1N7P A;  1RKY A;  4NEI A;  2NOJ A;  1MN0 A;  1NS4 A;  3ANI A;  4ZRP A;  1W5Z A;  5IKA A;  2WYN A;  4FJQ A;  2KXR A;  3BUP A;  2V8J A;  1L1Y A;  3SDU A;  1IVU A;  1IA7 A;  2WCO A;  3DPY B;  2E2V A;  3E80 A;  2RI8 A;  1KSI A;  1N7Q A;  1F9G A;  2AFA A;  2BRP A;  3HXF B;  3I3B A;  3E37 B;  1JCS B;  3K7X A;  4Q2B A;  3PYA A;  3QSP A;  1N7N A;  4ONT A;  1NL4 B;  1DOG A;  3CU7 A;  2WMK A;  3QXF A;  4RNL A;  1WU4 A;  1JZ7 A;  3KLS A;  4RNQ A;  2H6G B;  3W5N A;  1UI8 A;  1DCE B;  4EL8 A;  4BTY A;  3NJV A;  4OK4 A;  3SFX B;  3D51 A;  1HXA A;  1AGM A;  3Q78 B;  5ILZ A;  4BOK A;  2WZS A;  1GAI A;  2WMI A;  2WO0 A;  1X1H A;  1SA4 B;  3EJS A;  1FBW A;  1TQU A;  1LXK A;  1N4Q B;  1H3C A;  1HXG A;  3VD5 A;  3BS6 A;  1QAZ A;  2FYV A;  3WVF A;  3HXE B;  1HN0 A;  3QFY A;  3EJU A;  1GXO A;  1NSM A;  1JYX A;  3VDA A;  3X3X A;  2F7O A;  3M73 A;  1D6Z A;  1NS8 A;  3DX3 A;  1HTY A;  4TXT A;  2Q1F A;  3KSQ B;  3SAE A;  2OW6 A;  3I3E A;  5ILJ A;  3M7L A;  4DOE A;  4V1R A;  1JCR B;  1W6C A;  1HCU A;  3D5S A;  2WVY A;  2WII B;  2B4F A;  4ZG8 A;  1AVL A;  5GW7 A;  2FUT A;  2XFG A;  3HII A;  2GZ6 A;  5DGQ A;  1IQY A;  2ALW A;  1IA6 A;  2CFK A;  3Q1N A;  1V7W A;  4CJ0 A;  3RX8 A;  2FBA A;  5IK9 A;  3PQI A;  1IVX A;  2VN7 A;  4WVA A;  4D6F A;  3WA2 X;  4AYQ A;  3NBJ A;  2E2U A;  1TNU B;  4GTV B;  1GA2 A;  1RWF A;  3D4Y A;  2F1A A;  1N1Z A;  3QWT A;  4LNV A;  1NSR A;  3WIQ A;  3HXD B;  2XWJ B;  2XHN A;  3Q7F B;  2WYI A;  5DHK A;  4ZH1 A;  3HI7 A;  3WIW A;  1TNO B;  3MUY 1;  3DSS B;  2FV0 A;  1AV4 A;  3GLY A;  3MI6 A;  4V1S A;  1OJM A;  2J5C A;  2DRS A;  3W5M A;  2WY7 A;  1JCQ B;  3PZ2 B;  1I8Q A;  2SQC A;  1F4A A;  2QNO A;  2WW0 A;  1OJP A;  1S63 B;  3M71 A;  3WIR A;  1O6H A;  3W7U A;  2WMJ A;  2BT3 A;  2CG1 A;  1N4S B;  1TQT A;  1G87 A;  4D4C A;  4EV5 A;  4CJ1 A;  3VDB A;  1FO2 A;  4FNQ A;  3TF4 A;  1L7K A;  1JS4 A;  4MMI A;  3T33 A;  3D50 A;  5ILK A;  4GL3 A;  4BZF A;  1KKT A;  5ILI A;  2JG0 A;  3T2P A;  3VSN A;  1KZP B;  2A73 B;  5ILH A;  4CE7 A;  2D5J A;  3DST B;  4Z4J A;  1K1Y A;  1C82 A;  2WOF A;  3QFZ A;  1JYN A;  1W3Y A;  3EZ8 A;  3LOY A;  1QAF A;  3CZJ A;  4TTG A;  1VD5 A;  3U7V A;  1MMZ A;  2OOV C;  3W7W A;  1NS7 A;  1H35 A;  3I3D A;  1R34 A;  2BB6 A;  1H12 A;  1H36 A;  2FUZ A;  4E1Y A;  1V7X A;  2OW7 A;  4L6X A;  1W6G A;  3GZK A;  2CIR A;  3KSL B;  1DYU A;  4LIX A;  2CIS A;  3M76 A;  3K5T A;  1PX3 A;  3IAP A;  1AVK A;  1TQV A;  1LTX B;  4D94 A;  1V5D A;  2F1B A;  2V3N A;  3X3Y A;  2XQW A;  2AHG A;  1OJO A;  2DRR A;  3LVT A;  1HMU A;  1KRF A;  3Q73 B;  3UD2 A;  3KII A;  3PZ1 B;  3M77 A;  4JJJ A;  3DDG A;  4Q88 A;  3Q75 B;  2Y73 A;  4KFD A;  3SDR A;  4J5T A;  5C05 A;  3QRY A;  4MBG B;  4D71 A;  1NSS A;  1LOH A;  1YQ2 A;  1FT2 B;  3BLB A;  3X3Z A;  1LD8 B;  5CA3 A;  3EJP A;  1HZF A;  1X1J A;  4ZH5 A;  1GSZ A;  3CZS A;  4OK2 A;  3X40 A;  1O6Q A;  3PZ4 B;  1XWQ A;  1F4H A;  2E2T A;  1SNZ A;  4D6H A;  4FNU A;  2CG0 A;  3E30 B;  1US1 A;  4D72 A;  1DP0 A;  1N9E A;  1KZO B;  5JPM B;  1FAE A;  3Q79 B;  2X03 A;  1O7D D;  1CLC A;  1H39 A;  4WVB A;  1UG9 A;  1PX4 A;  3NNB A;  3DX0 A;  1X81 B;  4Z4L A;  1SO0 A;  1TN6 B;  3CZN A;  1OAC A;  3E34 B;  3TY1 A;  2WMI B;  3P2C A;  4KTP A;  3VSM A;  2WW1 A;  3IAQ A;  4KFF A;  3OB8 A;  1TNZ B;  3HXC B;  5EAT A;  2ZQ0 A;  3VD3 A;  3OS7 A;  2JKP A;  4TF4 A;  4D6J A;  3WFA A;  2JJB A;  1FMI A;  2A8Z A;  4KKJ A;  5E2J A;  1K1X A;  1H13 A;  3H7L A;  3AFJ A;  3RJ3 A;  1TN8 B;  2CWU A;  3DDF A;  4D4D A;  5JMF A;  4YCR A;  3OED A;  2OOV A;  1S64 B;  1KSD A;  1XW2 A;  5FOB B;  2ZBL A;  1QX1 A;  3K25 A;  3N0G A;  3CIH A;  1DL2 A;  3W7T A;  1R33 A;  3M75 A;  1RWA A;  1GXN A;  1QWN A;  1W2Z A;  4QT9 A;  3N9H A;  4FNV A;  2VN4 A;  2JKA A;  1N1B A;  1V7V A;  2CFG A;  4FUS A;  2ONH A;  3KBU C;  3BVX A;  1HV6 A;  2F7R A;  3RSY A;  3NBB A;  4WU0 A;  2CFD A;  2WVZ A;  3E1F 1;  2BED B;  2YFO A;  1CB8 A;  3M72 A;  4DI5 A;  3ANK A;  3DSX B;  1NS0 A;  2EAB A;  4FNR A;  2F18 A;  3M7C A;  1IVV A;  3SEP A;  1AYX A;  1NXC A;  1RWH A;  4UFC A;  1IQX A;  3QT9 A;  4OJZ A;  2WOH A;  3T0A A;  4K35 A;  2CFW A;  3DEC A;  2PMV A;  3X17 A;  1K1W A;  5JMD A;  1WMO A;  1O1T B;  2D1W A;  3EJR A;  4GTQ B;  2I07 B;  2E24 A;  5JPN B;  1KWF A;  1NSU A;  4BZG A;  3M02 A;  2BB5 A;  3EJT A;  1HXK A;  2JF4 A;  3M74 A;  4L0G A;  1LVN A;  3RX7 A;  4GTR B;  1JZ6 A;  3HXB B;  2YFN A;  1D6U A;  3QXQ A;  3SDQ A;  5IK0 A;  1EKM A;  3PZ3 B;  1PS3 A;  2NVP A;  3QR8 A;  3AMO A;  4GTM B;  3MPH A;  3MV1 1;  2D73 A;  3DCD A;  1WU6 A;  3BUQ A;  5ILD A;  3S4B A;  1D8E B;  4GTO B;  3E7J A;  2Z07 A;  1SII A;  4D6C A;  1R76 A;  3D4Z A;  3DYO A;  3PGB A;  4FNT A;  2R2L B;  3S4A A;  1O79 A;  5EAS A;  2XN1 A;  1H37 A;  5DHI A;  1TN7 B;  3Q7A B;  4BOJ A;  1JYW A;  1SQC A;  1QAK A;  3KQ4 A;  1H54 A;  4DLQ A;  2C10 A;  3J7H A;  3VDC A;  2B39 A;  3M00 A;  1D6Y A;  1JRQ A;  2Y74 A;  2EAD A;  3BVV A;  1QQF A;  1O5M B;  3M01 A;  2AHF A;  3WKH A;  3MV0 1;  4D4A A;  3DYP A;  3T2O A;  2ZIR B;  1H14 A;  2DRO A;  3WKF A;  2E22 A;  2RI9 A;  1TQS A;  3D3I A;  2BRW A;  5KBP A;  2XN0 A;  1N94 B;  1H3B A;  2WMH A;  1N7O A;  3WUX A;  2G02 A;  2RDY A;  3DSW B;  4M76 A;  4D6G A;  3BGA A;  2FV1 A;  1SA5 B;  1N7R A;  3AFL A;  3SXX A;  2CWT A;  1N24 A;  1IVW A;  3H3K A;  1LD7 B;  3DX4 A;  4DUX A;  1RQ5 A;  1TNB B;  3DX1 A;  1HN1 A;  1N9A B;  5E1Q A;  1NKG A;  1FT1 B;  1O1R B;  5IK6 A;  3PYB A;  2GH4 A;  5FO8 B;  1HMW A;  1QSJ A;  1W7C A;  2WW2 A;  3T08 A;  3A0O A;  1SIH A;  2OKX A;  1N4R B;  2D8L A;  2YX9 A;  1IS9 A;  4FXG B;  4DOD A;  1WU5 A;  3X41 A;  3G4F A;  1F9D A;  4EV2 A;  4BZH A;  3M7E A;  3UD1 A;  2CQS A;  1JZ3 A;  1HX9 A;  3G6J B;  1HXC A;  3ALA A;  3MUZ 1;  4DUV A;  4K3A A;  4DUW A;  4FXK B;  4BTX A;  2H6F B;  4ZRQ A;  1NC5 A;  4F13 A;  3C72 B;  1MMU A;  2KXS A;  1N23 A;  3SQC A;  1H3A A;  2WVX A;  1HM3 A;  1FCE A;  3S9V A;  1NS2 A;  3SFY B;  2WYH A;  1TQW A;  5KKB A;  3T2Q A;  2G0D A;  5IL3 A;  2XN2 A;  1NI1 B;  4AYR A;  3WA3 A;  1QBQ B;  1WMP A;  3MWX A;  1TU5 A;  4AYO A;  5ILY A;  2F7Q A;  1PU4 A;  2BBC A;  2H6H B;  3GT5 A;  3EU8 A;  1ULV A;  1O1S B;  1IU7 A;  4GAX A;  3T0B A;  2EAC A;  2GOX A;  4BZE A;  1LF6 A;  4MU9 A;  2H6I B;  4D6I A;  4C1S A;  3H2W A;  1CEM A;  3SX1 A;  2HTA A;  3W7X A;  3EUV B;  1JZ8 A;  1JZ5 A;  1WZZ A;  1JOV A;  3D52 A;  1FPP B;  1J0N A;  1KFG A;  1GLM A;  2F6D A;  1GHQ A;  2IEJ B;  1LXM A;  1C3D A;  3N0F A;  3VW5 A;  4F10 A;  3OBA A;  1G6I A;  1JYV A;  1QAL A;  4KFE A;  1TNY B;  1MZC B;  4YDO B;  3P5P A;  1FP3 A;  3M78 A;  4AQ0 A;  5IKH A;  3S4C A;  3WKI A;  3ECQ A;  1RWC A;  2C11 A;  3WKG A;  3DSU B;  1Z45 A;  3QDE A;  4GTS B;  4KKI A;  2XSG A;  1NSX A;  3BLC A;  3E33 B;  2F7P A;  1LF9 A;  2EAE A;  1N20 A;  5IM1 A;  2OQE C;  3T09 A;  1LUR A;  3WC3 A;  3NJX A;  5A1A A;  1JZ4 A;  5MEH A;  2PNC A;  2W0Q A;  3LZ9 A;  3BVW A;  1NSV A;  1W4N A;  3IMH A;  2CFL A;  1W6J A;  3D5R A;  4KTR A;  5AGD A;  4MMH A;  3KN4 A;  2V8I A;  1MMY A;  3NRE A;  3ON6 A;  4D6E A;  5M7I A;  3X42 A;  1W6K A;  5FO7 B;  2DRQ A;  3SDV A;  1GAH A;  1V5C A;  4FNS A;  2WW3 A;  2V8K A;  2ZXQ A;  1G9J A;  4D8O A;  3NFV A;  1SPU A;  3SDT A;  3W7S A;  1K72 A;  5M7Y A; 
#chains in the Genus database with same CATH homology
 2WMI A;  1NSS A;  4D71 A;  1X1H A;  2BRW A;  4J5T A;  1LOH A;  1YQ2 A;  4OZW A;  2WMH A;  1LXK A;  1N7O A;  4OZV A;  1X1J A;  1NSZ A;  3VD5 A;  3BS6 A;  4D6G A;  3BGA A;  1QAZ A;  3WVF A;  1HM2 A;  2CIQ A;  4OK2 A;  1HN0 A;  1F4H A;  1N7R A;  3AFL A;  4D6H A;  1SNZ A;  1NSM A;  1JYX A;  3VDA A;  1RW9 A;  1NS8 A;  4D72 A;  2Q1F A;  1DP0 A;  4DUX A;  3DYM A;  3I3E A;  1HN1 A;  2X03 A;  5E1Q A;  2WVY A;  2BRV X;  1NKG A;  1UG9 A;  2FUT A;  1PX4 A;  1JZ2 A;  3NNB A;  1HMW A;  2WW2 A;  3T08 A;  3A0O A;  1EGU A;  1SO0 A;  2WDA A;  1YGA A;  3Q1N A;  3TY1 A;  2WMI B;  3VSM A;  2WW1 A;  3IAQ A;  4BZH A;  4D6F A;  3OB8 A;  3VD7 A;  2ZQ0 A;  3VD3 A;  1JZ3 A;  3OS7 A;  1RWF A;  2JKP A;  3MUZ 1;  4D6J A;  3WFA A;  4DUV A;  4DUW A;  4D6D A;  1K1X A;  1NSR A;  4F13 A;  1MMU A;  2XHN A;  5JMF A;  3T0D A;  2WVX A;  3MUY 1;  1HM3 A;  1NS2 A;  3K25 A;  1OJM A;  1RWA A;  3A24 A;  1F1S A;  3T2Q A;  5A1A A;  4FNV A;  2JKA A;  1I8Q A;  1F4A A;  2HTB A;  1MMX A;  1HV6 A;  2WW0 A;  1OJP A;  2WVZ A;  3E1F 1;  3VD9 A;  2WMJ A;  1CB8 A;  1NS0 A;  3MWX A;  3SEP A;  1OJN A;  3VDB A;  1RWH A;  1L7K A;  2FUQ A;  4MMI A;  4OJZ A;  1ULV A;  4BZF A;  3T0A A;  3T0B A;  4BZE A;  3DEC A;  1TXK A;  1LF6 A;  1X1I A;  4D6I A;  2WMF A;  1J0M A;  3VSN A;  1K1W A;  3T2P A;  3VD4 A;  5JMD A;  2HTA A;  1K1Y A;  1C82 A;  2WVX B;  1JZ5 A;  2E24 A;  1JOV A;  1JZ8 A;  1RWG A;  2JKE A;  1JYN A;  1W3Y A;  2WMG A;  1J0N A;  1L7J A;  1NSU A;  3CZJ A;  3OBA A;  4BZG A;  1N7P A;  1LXM A;  4NEI A;  4F10 A;  1JYV A;  1MN0 A;  1MMZ A;  1NS4 A;  4TTG A;  1NS7 A;  3I3D A;  4AQ0 A;  1JZ6 A;  3ECQ A;  1RWC A;  4E1Y A;  1Z45 A;  2WCO A;  2XSG A;  3E80 A;  1NSX A;  3BLC A;  1N7Q A;  3MV1 1;  2D73 A;  1F9G A;  1LF9 A;  3DCD A;  2BRP A;  2CIR A;  3T09 A;  3I3B A;  1LUR A;  3E7J A;  3DYO A;  4D6C A;  2CIS A;  3NJX A;  1JZ4 A;  1N7N A;  1NSV A;  3IMH A;  1PX3 A;  2WMK A;  3IAP A;  4RNL A;  1JYW A;  4MMH A;  1MMY A;  3NRE A;  1JZ7 A;  3J7H A;  4D6E A;  1OJO A;  3VDC A;  1HMU A;  2WW3 A;  4OK4 A;  2ZXQ A;  3NJV A;  3MV0 1;  3DYP A;  3T2O A;  3NFV A;  2WZS A;  2E22 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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