1HMWA

Active site of chondroitinase ac lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis
Total Genus 236
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
236
sequence length
674
structure length
674
Chain Sequence
GTAELIMKRVMLDLKKPLRNMDKVAEKNLNTLQPDGSWKDVPYKDDAMTNWLPNNHLLQLETIIQAYIEKDSHYYGDDKVFDQISKAFKYWYDSDPKSRNWWHNEIATPQALGEMLILMRYGKKPLDEALVHKLTERMKRGEPEKKTGANKTDIALHYFYRALLTSDEALLSFAVKELFYPVQFVHYEEGLQYDYSYLQHGPQLQISSYGAVFITGVLKLANYVRDTPYALSTEKLAIFSKYYRDSYLKAIRGSYMDFNVEGRGVSRPDILNKKAEKKRLLVAKMIDLKHTEEWADAIARTDSTVAAGYKIEPYHHQFWNGDYVQHLRPAYSFNVRMVSKRTRRSESGNKENLLGRYLSDGATNIQLRGPEYYNIMPVWEWDKIPGITSRDYLTDRPLTKLWGEQGSNDFAGGVSDGVYGASAYALDYDSLQAKKAWFFFDKEIVCLGAGINSNAPENITTTLNQSWLNGPVISTAGKTGRGKITTFKAQGQFWLLHDAIGYYFPEGANLSLSTQSQKGNWFHINNSHSKDEVSGDVFKLWINHGARPENAQYAYIVLPGINKPEEIKKYNGTAPKVLANTNQLQAVYHQQLDMVQAIFYTAGKLSVAGIEIETDKPCAVLIKHINGKQVIWAADPLQKEKTAVLSIRDLKTGKTNRVKIDFPQQEFAGATVEL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis.
pubmed doi rcsb
molecule keywords CHONDROITINASE AC
molecule tags Lyase
source organism Pedobacter heparinus
total genus 236
structure length 674
sequence length 674
ec nomenclature ec 4.2.2.5: Chondroitin AC lyase.
pdb deposition date 2000-12-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02278 Lyase_8 Polysaccharide lyase family 8, super-sandwich domain
A PF02884 Lyase_8_C Polysaccharide lyase family 8, C-terminal beta-sandwich domain
A PF08124 Lyase_8_N Polysaccharide lyase family 8, N terminal alpha-helical domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.50.10.100 Mainly Alpha Alpha/alpha barrel Glycosyltransferase Chondroitin AC/alginate lyase 1hmwA01
2.60.220.10 Mainly Beta Sandwich Chondroitinase Ac; Chain A, domain 3 Polysaccharide lyase family 8-like, C-terminal 1hmwA03
2.70.98.10 Mainly Beta Distorted Sandwich Beta-galactosidase; Chain A, domain 5 Beta-galactosidase; Chain A, domain 5 1hmwA02
1N7OA 1L7KA 1HN0A 4AQ0A 3MV11 4D72A 1JZ2A 2E22A 3NREA 2ZQ0A 3I3EA 4MMIA 1JYVA 1NS8A 2JKEA 1JZ5A 1LURA 2WVXA 2BRWA 1NSSA 1X1IA 1Z45A 3OS7A 1MN0A 1JZ8A 2Q1FA 1F4AA 1JYXA 3OBAA 1OJOA 1OJNA 1DP0A 1NS7A 1QAZA 3IMHA 4DUXA 1UG9A 1JZ7A 3NNBA 2HTAA 1LXMA 1X1HA 2WMJA 2X03A 1NS2A 2XSGA 3IAQA 3VD5A 1HMUA 2ZXQA 1N7QA 3E7JA 1K1XA 2CISA 5E1QA 3T2OA 3VSNA 3VDAA 3WFAA 3VD3A 4FNVA 5JMFA 2WW1A 1J0MA 1HMWA 4D6CA 2XHNA 1JZ3A 1LF6A 4OJZA 1RWCA 1RWAA 1LF9A 1N7NA 1F4HA 4D6HA 1NSUA 5A1AA 2WMIA 1HV6A 2HTBA 3MUY1 2JKAA 1LOHA 1C82A 3BGAA 3VDCA 1JYWA 3AFLA 1CB8A 3VD7A 3VD4A 3T0DA 3NFVA 2JKPA 2BRVX 3DYMA 1TXKA 4D6EA 2E24A 2WMGA 1SO0A 2WDAA 3DYPA 4D6IA 4D71A 3T2QA 1I8QA 4BZGA 2WVXB 1JZ4A 1MMUA 2WVYA 1MMYA 2BRPA 2FUQA 3I3DA 1X1JA 3T09A 3Q1NA 1MMZA 1HM3A 2WW0A 1RWGA 3T0BA 3T2PA 1N7RA 3SEPA 3MV01 3MUZ1 2WW3A 3E1F1 2CIQA 3DECA 3K25A 2FUTA 4OZVA 3T0AA 4BZEA 3A0OA 4D6DA 4DUVA 4OK4A 4RNLA 2WVZA 3CZJA 3IAPA 4TTGA 4F13A 1NSVA 2WMFA 3NJXA 4F10A 2WMIB 1N7PA 1OJMA 1NSMA 3DYOA 1K1YA 4D6GA 1F9GA 3VDBA 3VD9A 4BZHA 1RWFA 1NSXA 1SNZA 3MWXA 2D73A 2CIRA 4MMHA 1RWHA 2WCOA 3E80A 1MMXA 1EGUA 1NKGA 1OJPA 1ULVA 1YQ2A 3OB8A 2WMKA 1NS0A 1JZ6A 4OK2A 4NEIA 1L7JA 1YGAA 1JOVA 4D6JA 4OZWA 1PX4A 3NJVA 4BZFA 1JYNA 1F1SA 3DCDA 1K1WA 1LXKA 1PX3A 3T08A 3I3BA 2WMHA 5JMDA 1HN1A 1J0NA 1NS4A 1NSZA 3J7HA 4DUWA 1HM2A 4D6FA 2WW2A 3ECQA 1W3YA 3A24A 3VSMA 2WZSA 4E1YA 1NSRA 1RW9A
chains in the Genus database with same CATH superfamily
3K7XA 1N7OA 1L7KA 2FV1A 4YCRA 2ZIRB 1D6YA 2E22A 4TXTA 2FUZA 3LZ9A 1H35A 1IA7A 4KTPA 4ZG8A 3X41A 3ANKA 4AYPA 1UT9A 1NS8A 1LURA 2XN1A 3S4BA 2WVXA 1KREA 4FJQA 3RX5A 1Z45A 1IA6A 2JG0A 3DRAB 2EABA 3UD1A 1JZ8A 2YX9A 1HX9A 1O6HA 3BUIA 1O1TB 1OJNA 3C72B 4BOKA 1NS7A 2WY7A 1UG9A 3EJUA 2CG0A 1PU4A 3E30B 3QR8A 1HXKA 1FP3A 1VD5A 3M71A 1H37A 1X9DA 3NNBA 3D3IA 1IVUA 1X1HA 3IAQA 2ZXQA 1N7QA 1K1XA 2ZISB 3S4DA 3W5NA 3EZ8A 2ALWA 3VD3A 3WIQA 2ZZRA 1KSCA 2H6FB 2DRQA 1FBWA 5JMFA 1J0MA 2XHNA 3BUQA 3DX2A 1JZ3A 1LF6A 2ONGA 1GLMA 1RWCA 3D4YA 2BB6A 2YFOA 1JS4A 1N9AB 5DGRA 5IK6A 2NOJA 1NSUA 5A1AA 4D4DA 1JYWA 1LOHA 3CZNA 1N4RB 4DODA 1FMIA 1TN7B 4K3AA 1QBQB 1XWTA 2BRVX 3ACSA 3D5RA 4L6XA 2JKPA 4BTYA 2SQCA 1O6QA 1TXKA 1LTXB 3MPHA 4FXKB 3DSTB 1N1ZA 1QSJA 3QDEA 1FO3A 2WVXB 3EJRA 1JZ4A 3DX3A 2VN4A 4ZH5A 4D1JA 5IL8A 1KKTA 2CFDA 2FUQA 1LD8B 3HIIA 3SQCA 3T0BA 4Z4LA 3N9HA 1G9JA 2WW3A 3KBTC 1IU7A 3DPYB 3DECA 1AVLA 4D6DA 4OK4A 4AYRA 3M7EA 4RNLA 3IAPA 3K5TA 4TTGA 3EUVB 3BVTA 3DSSB 3W7TA 3DSWB 1WU5A 1CLCA 1N95B 4C1SA 1K1YA 4D6GA 1L1YA 5IK0A 4WU0A 3VDBA 2H6IB 3H3KA 1NSXA 1RWHA 5ILHA 1FBOA 2WCOA 2CFGA 3M73A 1D6ZA 1MMXA 3NBJA 1KFGA 1YQ2A 1H3CA 1N94B 4BTXA 3OB8A 3N0GA 1L7JA 1KZPB 1AV4A 1YGAA 1AGMA 4OZWA 3D4ZA 3H2WA 2ONHA 3PQIA 4JJJA 3DCDA 2EACA 3OXUA 4KFEA 2CFWA 1R34A 1PX3A 2NVPA 1O79A 1G9GA 1CEMA 1PS3A 1WZZA 1TNYB 3WA3A 5JMDA 3J7HA 4UFCA 2OOVA 2G02A 4DI5A 4GTRB 5KKBA 2WYIA 2KXRA 2FYVA 2OW7A 1HCUA 2OQEA 3HXEB 3P5PA 1O7DD 1H13A 2WY8A 3QG0A 2D5JA 4AQ0A 1JZ2A 2GZ6A 1V7WA 1AVKA 3NREA 3ACTA 3I3EA 2DRSA 2OKXA 2WYNA 1K72A 2EAEA 3WC3A 4GAXA 5M7YA 1FPPB 1NSSA 1H12A 1GXNA 1SIIA 3OS7A 2J5CA 2WOFA 3OBAA 3BVXA 1QAZA 1D6UA 3X3ZA 4Q2BA 1IVVA 3G6JB 5GY3A 3SFYB 2HTAA 3WVFA 1LXMA 1FO2A 1H36A 5DHIA 2H6HB 3M01A 3PZ1B 1HMUA 1TQUA 2F6DA 2CISA 5E1QA 1GXOA 4FUSA 5GZKA 2QNOA 1WMNA 5CZLA 3RX7A 4D6CA 2XWJB 1TNBB 2RDYA 3BVVA 1QQFA 3U7VA 5EASA 1RWAA 5ILJA 2CWTA 1US1A 3KLSA 2WMIA 1HV6A 2YFNA 3VDCA 3E34B 3AFLA 3T0DA 3NFVA 1HZFA 3P5RA 3LVTA 2WGQA 2XN0A 3OEDA 3KIIA 4KKJA 3SDVA 4AYQA 2PN5A 3M02A 4D6IA 1WMOA 1I8QA 1A2VA 3T2QA 3TY1A 4BZGA 1NL4B 1IQYA 5ILZA 3SDQA 1TNZB 3BUPA 3Q78B 1O1SB 4FNUA 2JJBA 1W5ZA 4ONTA 1RWGA 3T2PA 3SEPA 1QAFA 1WMPA 3D5SA 3W7XA 2PNCA 3QFZA 3E32B 1HXGA 1SA5B 1AYXA 3T0AA 4BZEA 4DUVA 3VW5A 3CZJA 1LD7B 1N4QB 1LVNA 1NSVA 2F7RA 2WMFA 3E37B 4F10A 2WMIB 3BLBA 1OJMA 3QPFA 1NSMA 3DYOA 4GTVB 3Q7AB 2XN2A 1F9GA 3Q7FB 1SIHA 1FT2B 4FNPA 2E2VA 3MWXA 1W6GA 3Q79B 2D73A 3WA2X 4MMHA 3MI6A 3N0FA 4L9PB 3WIRA 4WVAA 1R76A 1NKGA 1OJPA 3SAEA 3CIHA 1QALA 4ZRQA 2H6GB 1NS0A 3ANIA 1V7VA 4D6JA 3PYBA 4RNQA 2WINB 1PX4A 5CA3A 1JCRB 1G87A 2F1AA 1JYNA 3AMOA 2ZL8A 1K1WA 2WYHA 1FCEA 1LXKA 1R33A 2A8ZA 4KFDA 1NI1B 1TN8B 1S64B 2F7OA 5FO7B 3DDFA 4FNTA 5EATA 3G4DA 2WMHA 1TQSA 2EADA 1SQCA 1W6KA 3M72A 1NSZA 2DROA 2KXSA 3M78A 3D50A 1RJOA 1W2ZA 2XFGA 5FO8B 1N24A 2WZSA 3HI7A 2OOVC 3DSXB 4E1YA 2W0QA 1S63B 2R2LB 1GAHA 5DGQA 4D94A 3TF4A 1HN0A 2WO0A 2OQEC 1O1RB 4D72A 4J5TA 1DOGA 3K11A 4D1IA 1L2AA 4GTMB 3SX1A 4MBGB 4AYOA 1JRQA 2V8KA 3HXDB 1JZ5A 1EKMA 2BRWA 2VN7A 1X1IA 2CWUA 2B4FA 1TN6B 1D8EB 3KBUC 4K35A 1OJOA 3IMHA 1DL2A 3EJPA 1N21A 1JZ7A 3BUDA 3RX8A 2Z07A 3EU5B 1HTYA 2WMJA 3H7LA 4KTRA 3A3VA 1NS2A 1W6CA 2XSGA 3AMOB 3SXXA 5GW7A 3NBBA 3E7JA 3VDAA 1KWFA 2C10A 3E73A 1HMWA 1H54A 1JCSB 3PZ3B 3RSYA 1LF9A 3X40A 4D6HA 3QT3A 3BLCA 1DCEB 1KS8A 1SA4B 2HTBA 1N9EA 2JKAA 3BGAA 1C82A 1N23A 3MUY1 3ALAA 3VD7A 3DYMA 3BS6A 2C11A 4D6EA 2E24A 1SO0A 2WDAA 4L0GA 1WU4A 3D52A 4KKIA 4GTPB 2BBCA 4ZH1A 5FOBB 3QSPA 2RGKA 3HXCB 3M77A 5JPMB 4CE7A 3W5MA 2WVYA 3UD2A 1NC5A 2BRPA 3W7SA 3BUBA 1KRFA 1N20A 1W4NA 3DSUB 1X81B 1HM3A 4M76A 1MMZA 1GAIA 1TNOB 1IS9A 2V8JA 5IK9A 1N7RA 1UI8A 3MV01 3M00A 3QRYA 1TNUB 4FXGB 3E1F1 3EJTA 1V5DA 3PMMA 2FUTA 3K25A 4WVBA 2D1WA 1KSDA 4QT9A 4F13A 2G0DA 2B39A 3NJXA 3EU8A 4LIXA 5ILKA 3M7CA 2BB5A 3W7UA 1D8DB 4GL3A 5EAUA 2F1BA 2AHFA 2GH4A 3WUXA 4BZHA 4D4BA 1SNZA 2CIRA 3BVUA 3QT9A 4GTOB 1H3BA 1TF4A 3E80A 1EGUA 4BTWA 2PMVA 3CU7A 3VXDA 1GXMA 4DLOA 3HXBB 4OK2A 4NEIA 1JZ6A 3M75A 5ILDA 3X3YA 5E2JA 1W7CA 2Y74A 3SFXB 3QXQA 3ON6A 1GSZA 1F1SA 5IKHA 5KBPA 1NXCA 3X3XA 3QFYA 1FT1B 3DX0A 2XQWA 5MEHA 2OW6A 3KSLB 3WKIA 4DLQA 3T33A 1HN1A 3E6UA 1NS4A 2ZBLA 3ANJA 3HIGA 4KFFA 1RKYA 1HXCA 1G6IA 1C3DA 3X42A 2RI9A 1FAEA 1W3YA 5CD2A 4Z4JA 2FV0A 1GA2A 1NSRA 1RW9A 4DOEA 2AFAA 5M7IA 1TQTA 4DUWA 3KSQB 3HXFB 3W7WA 3MV11 4FNSA 1V7XA 1N4SB 4TF4A 4Q88A 2ZQ0A 1GHQA 2F7PA 4MMIA 3M7BA 4EV2A 1JYVA 2JKEA 4EL8A 5FO9B 1MN0A 2Q1FA 4EHMB 1F4AA 3D51A 1JYXA 2F7QA 1DP0A 3S4CA 4DUXA 3WIWA 5JPNB 3WKFA 3EJSA 1WU6A 3PZ2B 3S4AA 3VD5A 3M7LA 2X03A 4D4AA 3M74A 1OACA 3T2OA 3P2CA 2RI8A 3VSNA 3WFAA 1H39A 2YIKA 2F0YB 4FNVA 2I07B 2WW1A 2P0VA 5IKAA 4OJZA 2JF4A 3AFJA 1N7NA 1F4HA 3RENA 3DX4A 3KN4A 4MU9A 5AGDA 1CB8A 3VD4A 1V5CA 1N1BA 1H3AA 4ZRPA 3BVWA 1TQVA 2D8LA 2GOXA 2WMGA 2V8IA 3DX1A 1QAKA 3DYPA 4BOJA 2WIIB 4D71A 3KQ4A 1N22A 5C05A 3RJ3A 1HWWA 3QXFA 4V1SA 2BT3A 1JCQB 5ILIA 3CZSA 4D8OA 1DYUA 3LOYA 1MZCB 1MMUA 2WOHA 4GTSB 4FNRA 4LNGB 1MMYA 4V1RA 1X1JA 3I3DA 4WVCA 1KZOB 3T09A 2E2UA 3Q1NA 1IVXA 1H14A 3X17A 3SDUA 2V3NA 2WW0A 2Y73A 4EV5A 3RRSA 3MUZ1 2CIQA 2FBAA 2CQSA 3GZKA 2A73B 3Q73B 4OZVA 3A0OA 3SDRA 1XW2A 5ILYA 1IVWA 4GTQB 3QWTA 2WVZA 3EQAA 2AHGA 2V3PA 4LNBB 1O5MB 1O6RA 1N7PA 3GLYA 5IM1A 3PZ4B 3CV5A 3DDGA 1SPUA 3E33B 3SDTA 2CFKA 3M76A 3PYAA 2CFLA 1RWFA 2CWVA 3WKHA 3VD9A 1F9DA 3G4FA 1TU5A 2CG1A 4CJ0A 2E2TA 4XUVA 1UMPA 3S9VA 4D4CA 3T0UA 1ULVA 1F9OA 2WMKA 2CQTA 5IL3A 2BEDB 3WKGA 1JOVA 1RQ5A 4LNVA 3PGBA 3NJVA 1HXAA 4BZFA 1QWUA 3GT5A 3Q75B 1KSIA 4GTTB 2F18A 3T08A 3EJQA 3DSVB 3F59A 4YDEB 2IEJB 1TQWA 3I3BA 4FNQA 4CJ1A 1QX1A 2DRRA 4YDOB 1J0NA 5DHKA 1IQXA 1HM2A 4D6FA 1UI7A 2WW2A 3ECQA 3A24A 3VSMA 1XWQA 1QWNA 1W6JA 2XWBB 1N4PB
chains in the Genus database with same CATH topology
1N7OA 1L7KA 1HN0A 4AQ0A 3MV11 4D72A 1JZ2A 2E22A 4J5TA 3NREA 2ZQ0A 3I3EA 4MMIA 1JYVA 1NS8A 2JKEA 1JZ5A 1LURA 2WVXA 2BRWA 1NSSA 1X1IA 1Z45A 3OS7A 1MN0A 1JZ8A 2Q1FA 1F4AA 1JYXA 3OBAA 1OJOA 1OJNA 1DP0A 1NS7A 1QAZA 3IMHA 4DUXA 1UG9A 1JZ7A 3NNBA 2HTAA 3WVFA 1LXMA 1X1HA 2WMJA 2X03A 1NS2A 2XSGA 3IAQA 3VD5A 1HMUA 2ZXQA 1N7QA 3E7JA 1K1XA 2CISA 5E1QA 3T2OA 3VSNA 3VDAA 3WFAA 3VD3A 4FNVA 5JMFA 2WW1A 1J0MA 1HMWA 4D6CA 2XHNA 1JZ3A 1LF6A 4OJZA 1RWCA 1RWAA 1LF9A 1N7NA 1F4HA 4D6HA 1NSUA 3BLCA 2WMIA 1HV6A 5A1AA 2HTBA 3MUY1 2JKAA 1LOHA 1C82A 3BGAA 3VDCA 1JYWA 3AFLA 1CB8A 3VD7A 3VD4A 3T0DA 3NFVA 2JKPA 2BRVX 3BS6A 3DYMA 1TXKA 4D6EA 2E24A 2WMGA 1SO0A 2WDAA 3DYPA 4D6IA 4D71A 3T2QA 1I8QA 4BZGA 3TY1A 2WVXB 1JZ4A 1MMUA 2WVYA 1MMYA 2BRPA 2FUQA 3I3DA 1X1JA 3T09A 3Q1NA 1MMZA 1HM3A 2WW0A 1RWGA 3T0BA 3T2PA 1N7RA 3SEPA 3MV01 3MUZ1 2WW3A 3E1F1 2CIQA 3DECA 3K25A 2FUTA 4OZVA 3T0AA 4BZEA 3A0OA 4D6DA 4DUVA 4OK4A 4RNLA 2WVZA 3CZJA 3IAPA 4TTGA 4F13A 1NSVA 2WMFA 3NJXA 4F10A 2WMIB 1N7PA 1OJMA 1NSMA 3DYOA 1K1YA 4D6GA 1F9GA 3VDBA 3VD9A 4BZHA 1RWFA 1NSXA 1SNZA 3MWXA 2D73A 2CIRA 4MMHA 1RWHA 2WCOA 3E80A 1MMXA 1EGUA 1NKGA 1OJPA 1ULVA 1YQ2A 3OB8A 2WMKA 1NS0A 1JZ6A 4OK2A 4NEIA 1L7JA 1YGAA 1JOVA 4D6JA 4OZWA 1PX4A 3NJVA 4BZFA 1JYNA 1F1SA 3DCDA 1K1WA 1LXKA 1PX3A 3T08A 3I3BA 2WMHA 5JMDA 1HN1A 1J0NA 1NS4A 1NSZA 3J7HA 4DUWA 1HM2A 4D6FA 2WW2A 3ECQA 1W3YA 3A24A 3VSMA 2WZSA 4E1YA 1NSRA 1RW9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1N7O A;  1L7K A;  1HN0 A;  4AQ0 A;  3MV1 1;  4D72 A;  1JZ2 A;  2E22 A;  3NRE A;  2ZQ0 A;  3I3E A;  4MMI A;  1JYV A;  1NS8 A;  2JKE A;  1JZ5 A;  1LUR A;  2WVX A;  2BRW A;  1NSS A;  1X1I A;  1Z45 A;  3OS7 A;  1MN0 A;  1JZ8 A;  2Q1F A;  1F4A A;  1JYX A;  3OBA A;  1OJO A;  1OJN A;  1DP0 A;  1NS7 A;  1QAZ A;  3IMH A;  4DUX A;  1UG9 A;  1JZ7 A;  3NNB A;  2HTA A;  1LXM A;  1X1H A;  2WMJ A;  2X03 A;  1NS2 A;  2XSG A;  3IAQ A;  3VD5 A;  1HMU A;  2ZXQ A;  1N7Q A;  3E7J A;  1K1X A;  2CIS A;  5E1Q A;  3T2O A;  3VSN A;  3VDA A;  3WFA A;  3VD3 A;  4FNV A;  5JMF A;  2WW1 A;  1J0M A;  1HMW A;  4D6C A;  2XHN A;  1JZ3 A;  1LF6 A;  4OJZ A;  1RWC A;  1RWA A;  1LF9 A;  1N7N A;  1F4H A;  4D6H A;  1NSU A;  5A1A A;  2WMI A;  1HV6 A;  2HTB A;  3MUY 1;  2JKA A;  1LOH A;  1C82 A;  3BGA A;  3VDC A;  1JYW A;  3AFL A;  1CB8 A;  3VD7 A;  3VD4 A;  3T0D A;  3NFV A;  2JKP A;  2BRV X;  3DYM A;  1TXK A;  4D6E A;  2E24 A;  2WMG A;  1SO0 A;  2WDA A;  3DYP A;  4D6I A;  4D71 A;  3T2Q A;  1I8Q A;  4BZG A;  2WVX B;  1JZ4 A;  1MMU A;  2WVY A;  1MMY A;  2BRP A;  2FUQ A;  3I3D A;  1X1J A;  3T09 A;  3Q1N A;  1MMZ A;  1HM3 A;  2WW0 A;  1RWG A;  3T0B A;  3T2P A;  1N7R A;  3SEP A;  3MV0 1;  3MUZ 1;  2WW3 A;  3E1F 1;  2CIQ A;  3DEC A;  3K25 A;  2FUT A;  4OZV A;  3T0A A;  4BZE A;  3A0O A;  4D6D A;  4DUV A;  4OK4 A;  4RNL A;  2WVZ A;  3CZJ A;  3IAP A;  4TTG A;  4F13 A;  1NSV A;  2WMF A;  3NJX A;  4F10 A;  2WMI B;  1N7P A;  1OJM A;  1NSM A;  3DYO A;  1K1Y A;  4D6G A;  1F9G A;  3VDB A;  3VD9 A;  4BZH A;  1RWF A;  1NSX A;  1SNZ A;  3MWX A;  2D73 A;  2CIR A;  4MMH A;  1RWH A;  2WCO A;  3E80 A;  1MMX A;  1EGU A;  1NKG A;  1OJP A;  1ULV A;  1YQ2 A;  3OB8 A;  2WMK A;  1NS0 A;  1JZ6 A;  4OK2 A;  4NEI A;  1L7J A;  1YGA A;  1JOV A;  4D6J A;  4OZW A;  1PX4 A;  3NJV A;  4BZF A;  1JYN A;  1F1S A;  3DCD A;  1K1W A;  1LXK A;  1PX3 A;  3T08 A;  3I3B A;  2WMH A;  5JMD A;  1HN1 A;  1J0N A;  1NS4 A;  1NSZ A;  3J7H A;  4DUW A;  1HM2 A;  4D6F A;  2WW2 A;  3ECQ A;  1W3Y A;  3A24 A;  3VSM A;  2WZS A;  4E1Y A;  1NSR A;  1RW9 A; 
#chains in the Genus database with same CATH topology
 3K7X A;  1N7O A;  1L7K A;  2FV1 A;  4YCR A;  2ZIR B;  1D6Y A;  2E22 A;  4TXT A;  2FUZ A;  3LZ9 A;  1H35 A;  1IA7 A;  4KTP A;  4ZG8 A;  3X41 A;  3ANK A;  4AYP A;  1UT9 A;  1NS8 A;  1LUR A;  2XN1 A;  3S4B A;  2WVX A;  1KRE A;  4FJQ A;  3RX5 A;  1Z45 A;  1IA6 A;  2JG0 A;  3DRA B;  2EAB A;  3UD1 A;  1JZ8 A;  2YX9 A;  1HX9 A;  1O6H A;  3BUI A;  1O1T B;  1OJN A;  3C72 B;  4BOK A;  1NS7 A;  2WY7 A;  1UG9 A;  3EJU A;  2CG0 A;  1PU4 A;  3E30 B;  3QR8 A;  1HXK A;  1FP3 A;  1VD5 A;  3M71 A;  1H37 A;  1X9D A;  3NNB A;  3D3I A;  1IVU A;  1X1H A;  3IAQ A;  2ZXQ A;  1N7Q A;  1K1X A;  2ZIS B;  3S4D A;  3W5N A;  3EZ8 A;  2ALW A;  3VD3 A;  3WIQ A;  2ZZR A;  1KSC A;  2H6F B;  2DRQ A;  1FBW A;  5JMF A;  1J0M A;  2XHN A;  3BUQ A;  3DX2 A;  1JZ3 A;  1LF6 A;  2ONG A;  1GLM A;  1RWC A;  3D4Y A;  2BB6 A;  2YFO A;  1JS4 A;  1N9A B;  5DGR A;  5IK6 A;  2NOJ A;  1NSU A;  5A1A A;  4D4D A;  1JYW A;  1LOH A;  3CZN A;  1N4R B;  4DOD A;  1FMI A;  1TN7 B;  4K3A A;  1QBQ B;  1XWT A;  2BRV X;  3ACS A;  3D5R A;  4L6X A;  2JKP A;  4BTY A;  2SQC A;  1O6Q A;  1TXK A;  1LTX B;  3MPH A;  4FXK B;  3DST B;  1N1Z A;  1QSJ A;  3QDE A;  1FO3 A;  2WVX B;  3EJR A;  1JZ4 A;  3DX3 A;  2VN4 A;  4ZH5 A;  4D1J A;  5IL8 A;  1KKT A;  2CFD A;  2FUQ A;  1LD8 B;  3HII A;  3SQC A;  3T0B A;  4Z4L A;  3N9H A;  1G9J A;  2WW3 A;  3KBT C;  1IU7 A;  3DPY B;  3DEC A;  1AVL A;  4D6D A;  4OK4 A;  4AYR A;  3M7E A;  4RNL A;  3IAP A;  3K5T A;  4TTG A;  3EUV B;  3BVT A;  3DSS B;  3W7T A;  3DSW B;  1WU5 A;  1CLC A;  1N95 B;  4C1S A;  1K1Y A;  4D6G A;  1L1Y A;  5IK0 A;  4WU0 A;  3VDB A;  2H6I B;  3H3K A;  1NSX A;  1RWH A;  5ILH A;  1FBO A;  2WCO A;  2CFG A;  3M73 A;  1D6Z A;  1MMX A;  3NBJ A;  1KFG A;  1YQ2 A;  1H3C A;  1N94 B;  4BTX A;  3OB8 A;  3N0G A;  1L7J A;  1KZP B;  1AV4 A;  1YGA A;  1AGM A;  4OZW A;  3D4Z A;  3H2W A;  2ONH A;  3PQI A;  4JJJ A;  3DCD A;  2EAC A;  3OXU A;  4KFE A;  2CFW A;  1R34 A;  1PX3 A;  2NVP A;  1O79 A;  1G9G A;  1CEM A;  1PS3 A;  1WZZ A;  1TNY B;  3WA3 A;  5JMD A;  3J7H A;  4UFC A;  2OOV A;  2G02 A;  4DI5 A;  4GTR B;  5KKB A;  2WYI A;  2KXR A;  2FYV A;  2OW7 A;  1HCU A;  2OQE A;  3HXE B;  3P5P A;  1O7D D;  1H13 A;  2WY8 A;  3QG0 A;  2D5J A;  4AQ0 A;  1JZ2 A;  2GZ6 A;  1V7W A;  1AVK A;  3NRE A;  3ACT A;  3I3E A;  2DRS A;  2OKX A;  2WYN A;  1K72 A;  2EAE A;  3WC3 A;  4GAX A;  5M7Y A;  1FPP B;  1NSS A;  1H12 A;  1GXN A;  1SII A;  3OS7 A;  2J5C A;  2WOF A;  3OBA A;  3BVX A;  1QAZ A;  1D6U A;  3X3Z A;  4Q2B A;  1IVV A;  3G6J B;  5GY3 A;  3SFY B;  2HTA A;  3WVF A;  1LXM A;  1FO2 A;  1H36 A;  5DHI A;  2H6H B;  3M01 A;  3PZ1 B;  1HMU A;  1TQU A;  2F6D A;  2CIS A;  5E1Q A;  1GXO A;  4FUS A;  5GZK A;  2QNO A;  1WMN A;  5CZL A;  3RX7 A;  4D6C A;  2XWJ B;  1TNB B;  2RDY A;  3BVV A;  1QQF A;  3U7V A;  5EAS A;  1RWA A;  5ILJ A;  2CWT A;  1US1 A;  3KLS A;  2WMI A;  1HV6 A;  2YFN A;  3VDC A;  3E34 B;  3AFL A;  3T0D A;  3NFV A;  1HZF A;  3P5R A;  3LVT A;  2WGQ A;  2XN0 A;  3OED A;  3KII A;  4KKJ A;  3SDV A;  4AYQ A;  2PN5 A;  3M02 A;  4D6I A;  1WMO A;  1I8Q A;  1A2V A;  3T2Q A;  3TY1 A;  4BZG A;  1NL4 B;  1IQY A;  5ILZ A;  3SDQ A;  1TNZ B;  3BUP A;  3Q78 B;  1O1S B;  4FNU A;  2JJB A;  1W5Z A;  4ONT A;  1RWG A;  3T2P A;  3SEP A;  1QAF A;  1WMP A;  3D5S A;  3W7X A;  2PNC A;  3QFZ A;  3E32 B;  1HXG A;  1SA5 B;  1AYX A;  3T0A A;  4BZE A;  4DUV A;  3VW5 A;  3CZJ A;  1LD7 B;  1N4Q B;  1LVN A;  1NSV A;  2F7R A;  2WMF A;  3E37 B;  4F10 A;  2WMI B;  3BLB A;  1OJM A;  3QPF A;  1NSM A;  3DYO A;  4GTV B;  3Q7A B;  2XN2 A;  1F9G A;  3Q7F B;  1SIH A;  1FT2 B;  4FNP A;  2E2V A;  3MWX A;  1W6G A;  3Q79 B;  2D73 A;  3WA2 X;  4MMH A;  3MI6 A;  3N0F A;  4L9P B;  3WIR A;  4WVA A;  1R76 A;  1NKG A;  1OJP A;  3SAE A;  3CIH A;  1QAL A;  4ZRQ A;  2H6G B;  1NS0 A;  3ANI A;  1V7V A;  4D6J A;  3PYB A;  4RNQ A;  2WIN B;  1PX4 A;  5CA3 A;  1JCR B;  1G87 A;  2F1A A;  1JYN A;  3AMO A;  2ZL8 A;  1K1W A;  2WYH A;  1FCE A;  1LXK A;  1R33 A;  2A8Z A;  4KFD A;  1NI1 B;  1TN8 B;  1S64 B;  2F7O A;  5FO7 B;  3DDF A;  4FNT A;  5EAT A;  3G4D A;  2WMH A;  1TQS A;  2EAD A;  1SQC A;  1W6K A;  3M72 A;  1NSZ A;  2DRO A;  2KXS A;  3M78 A;  3D50 A;  1RJO A;  1W2Z A;  2XFG A;  5FO8 B;  1N24 A;  2WZS A;  3HI7 A;  2OOV C;  3DSX B;  4E1Y A;  2W0Q A;  1S63 B;  2R2L B;  1GAH A;  5DGQ A;  4D94 A;  3TF4 A;  1HN0 A;  2WO0 A;  2OQE C;  1O1R B;  4D72 A;  4J5T A;  1DOG A;  3K11 A;  4D1I A;  1L2A A;  4GTM B;  3SX1 A;  4MBG B;  4AYO A;  1JRQ A;  2V8K A;  3HXD B;  1JZ5 A;  1EKM A;  2BRW A;  2VN7 A;  1X1I A;  2CWU A;  2B4F A;  1TN6 B;  1D8E B;  3KBU C;  4K35 A;  1OJO A;  3IMH A;  1DL2 A;  3EJP A;  1N21 A;  1JZ7 A;  3BUD A;  3RX8 A;  2Z07 A;  3EU5 B;  1HTY A;  2WMJ A;  3H7L A;  4KTR A;  3A3V A;  1NS2 A;  1W6C A;  2XSG A;  3AMO B;  3SXX A;  5GW7 A;  3NBB A;  3E7J A;  3VDA A;  1KWF A;  2C10 A;  3E73 A;  1HMW A;  1H54 A;  1JCS B;  3PZ3 B;  3RSY A;  1LF9 A;  3X40 A;  4D6H A;  3QT3 A;  3BLC A;  1DCE B;  1KS8 A;  1SA4 B;  2HTB A;  1N9E A;  2JKA A;  3BGA A;  1C82 A;  1N23 A;  3MUY 1;  3ALA A;  3VD7 A;  3DYM A;  3BS6 A;  2C11 A;  4D6E A;  2E24 A;  1SO0 A;  2WDA A;  4L0G A;  1WU4 A;  3D52 A;  4KKI A;  4GTP B;  2BBC A;  4ZH1 A;  5FOB B;  3QSP A;  2RGK A;  3HXC B;  3M77 A;  5JPM B;  4CE7 A;  3W5M A;  2WVY A;  3UD2 A;  1NC5 A;  2BRP A;  3W7S A;  3BUB A;  1KRF A;  1N20 A;  1W4N A;  3DSU B;  1X81 B;  1HM3 A;  4M76 A;  1MMZ A;  1GAI A;  1TNO B;  1IS9 A;  2V8J A;  5IK9 A;  1N7R A;  1UI8 A;  3MV0 1;  3M00 A;  3QRY A;  1TNU B;  4FXG B;  3E1F 1;  3EJT A;  1V5D A;  3PMM A;  2FUT A;  3K25 A;  4WVB A;  2D1W A;  1KSD A;  4QT9 A;  4F13 A;  2G0D A;  2B39 A;  3NJX A;  3EU8 A;  4LIX A;  5ILK A;  3M7C A;  2BB5 A;  3W7U A;  1D8D B;  4GL3 A;  5EAU A;  2F1B A;  2AHF A;  2GH4 A;  3WUX A;  4BZH A;  4D4B A;  1SNZ A;  2CIR A;  3BVU A;  3QT9 A;  4GTO B;  1H3B A;  1TF4 A;  3E80 A;  1EGU A;  4BTW A;  2PMV A;  3CU7 A;  3VXD A;  1GXM A;  4DLO A;  3HXB B;  4OK2 A;  4NEI A;  1JZ6 A;  3M75 A;  5ILD A;  3X3Y A;  5E2J A;  1W7C A;  2Y74 A;  3SFX B;  3QXQ A;  3ON6 A;  1GSZ A;  1F1S A;  5IKH A;  5KBP A;  1NXC A;  3X3X A;  3QFY A;  1FT1 B;  3DX0 A;  2XQW A;  5MEH A;  2OW6 A;  3KSL B;  3WKI A;  4DLQ A;  3T33 A;  1HN1 A;  3E6U A;  1NS4 A;  2ZBL A;  3ANJ A;  3HIG A;  4KFF A;  1RKY A;  1HXC A;  1G6I A;  1C3D A;  3X42 A;  2RI9 A;  1FAE A;  1W3Y A;  5CD2 A;  4Z4J A;  2FV0 A;  1GA2 A;  1NSR A;  1RW9 A;  4DOE A;  2AFA A;  5M7I A;  1TQT A;  4DUW A;  3KSQ B;  3HXF B;  3W7W A;  3MV1 1;  4FNS A;  1V7X A;  1N4S B;  4TF4 A;  4Q88 A;  2ZQ0 A;  1GHQ A;  2F7P A;  4MMI A;  3M7B A;  4EV2 A;  1JYV A;  2JKE A;  4EL8 A;  5FO9 B;  1MN0 A;  2Q1F A;  4EHM B;  1F4A A;  3D51 A;  1JYX A;  2F7Q A;  1DP0 A;  3S4C A;  4DUX A;  3WIW A;  5JPN B;  3WKF A;  3EJS A;  1WU6 A;  3PZ2 B;  3S4A A;  3VD5 A;  3M7L A;  2X03 A;  4D4A A;  3M74 A;  1OAC A;  3T2O A;  3P2C A;  2RI8 A;  3VSN A;  3WFA A;  1H39 A;  2YIK A;  2F0Y B;  4FNV A;  2I07 B;  2WW1 A;  2P0V A;  5IKA A;  4OJZ A;  2JF4 A;  3AFJ A;  1N7N A;  1F4H A;  3REN A;  3DX4 A;  3KN4 A;  4MU9 A;  5AGD A;  1CB8 A;  3VD4 A;  1V5C A;  1N1B A;  1H3A A;  4ZRP A;  3BVW A;  1TQV A;  2D8L A;  2GOX A;  2WMG A;  2V8I A;  3DX1 A;  1QAK A;  3DYP A;  4BOJ A;  2WII B;  4D71 A;  3KQ4 A;  1N22 A;  5C05 A;  3RJ3 A;  1HWW A;  3QXF A;  4V1S A;  2BT3 A;  1JCQ B;  5ILI A;  3CZS A;  4D8O A;  1DYU A;  3LOY A;  1MZC B;  1MMU A;  2WOH A;  4GTS B;  4FNR A;  4LNG B;  1MMY A;  4V1R A;  1X1J A;  3I3D A;  4WVC A;  1KZO B;  3T09 A;  2E2U A;  3Q1N A;  1IVX A;  1H14 A;  3X17 A;  3SDU A;  2V3N A;  2WW0 A;  2Y73 A;  4EV5 A;  3RRS A;  3MUZ 1;  2CIQ A;  2FBA A;  2CQS A;  3GZK A;  2A73 B;  3Q73 B;  4OZV A;  3A0O A;  3SDR A;  1XW2 A;  5ILY A;  1IVW A;  4GTQ B;  3QWT A;  2WVZ A;  3EQA A;  2AHG A;  2V3P A;  4LNB B;  1O5M B;  1O6R A;  1N7P A;  3GLY A;  5IM1 A;  3PZ4 B;  3CV5 A;  3DDG A;  1SPU A;  3E33 B;  3SDT A;  2CFK A;  3M76 A;  3PYA A;  2CFL A;  1RWF A;  2CWV A;  3WKH A;  3VD9 A;  1F9D A;  3G4F A;  1TU5 A;  2CG1 A;  4CJ0 A;  2E2T A;  4XUV A;  1UMP A;  3S9V A;  4D4C A;  3T0U A;  1ULV A;  1F9O A;  2WMK A;  2CQT A;  5IL3 A;  2BED B;  3WKG A;  1JOV A;  1RQ5 A;  4LNV A;  3PGB A;  3NJV A;  1HXA A;  4BZF A;  1QWU A;  3GT5 A;  3Q75 B;  1KSI A;  4GTT B;  2F18 A;  3T08 A;  3EJQ A;  3DSV B;  3F59 A;  4YDE B;  2IEJ B;  1TQW A;  3I3B A;  4FNQ A;  4CJ1 A;  1QX1 A;  2DRR A;  4YDO B;  1J0N A;  5DHK A;  1IQX A;  1HM2 A;  4D6F A;  1UI7 A;  2WW2 A;  3ECQ A;  3A24 A;  3VSM A;  1XWQ A;  1QWN A;  1W6J A;  2XWB B;  1N4P B; 
#chains in the Genus database with same CATH homology
 1N7O A;  1L7K A;  1HN0 A;  4AQ0 A;  3MV1 1;  4D72 A;  1JZ2 A;  2E22 A;  4J5T A;  3NRE A;  2ZQ0 A;  3I3E A;  4MMI A;  1JYV A;  1NS8 A;  2JKE A;  1JZ5 A;  1LUR A;  2WVX A;  2BRW A;  1NSS A;  1X1I A;  1Z45 A;  3OS7 A;  1MN0 A;  1JZ8 A;  2Q1F A;  1F4A A;  1JYX A;  3OBA A;  1OJO A;  1OJN A;  1DP0 A;  1NS7 A;  1QAZ A;  3IMH A;  4DUX A;  1UG9 A;  1JZ7 A;  3NNB A;  2HTA A;  3WVF A;  1LXM A;  1X1H A;  2WMJ A;  2X03 A;  1NS2 A;  2XSG A;  3IAQ A;  3VD5 A;  1HMU A;  2ZXQ A;  1N7Q A;  3E7J A;  1K1X A;  2CIS A;  5E1Q A;  3T2O A;  3VSN A;  3VDA A;  3WFA A;  3VD3 A;  4FNV A;  5JMF A;  2WW1 A;  1J0M A;  1HMW A;  4D6C A;  2XHN A;  1JZ3 A;  1LF6 A;  4OJZ A;  1RWC A;  1RWA A;  1LF9 A;  1N7N A;  1F4H A;  4D6H A;  1NSU A;  3BLC A;  2WMI A;  1HV6 A;  5A1A A;  2HTB A;  3MUY 1;  2JKA A;  1LOH A;  1C82 A;  3BGA A;  3VDC A;  1JYW A;  3AFL A;  1CB8 A;  3VD7 A;  3VD4 A;  3T0D A;  3NFV A;  2JKP A;  2BRV X;  3BS6 A;  3DYM A;  1TXK A;  4D6E A;  2E24 A;  2WMG A;  1SO0 A;  2WDA A;  3DYP A;  4D6I A;  4D71 A;  3T2Q A;  1I8Q A;  4BZG A;  3TY1 A;  2WVX B;  1JZ4 A;  1MMU A;  2WVY A;  1MMY A;  2BRP A;  2FUQ A;  3I3D A;  1X1J A;  3T09 A;  3Q1N A;  1MMZ A;  1HM3 A;  2WW0 A;  1RWG A;  3T0B A;  3T2P A;  1N7R A;  3SEP A;  3MV0 1;  3MUZ 1;  2WW3 A;  3E1F 1;  2CIQ A;  3DEC A;  3K25 A;  2FUT A;  4OZV A;  3T0A A;  4BZE A;  3A0O A;  4D6D A;  4DUV A;  4OK4 A;  4RNL A;  2WVZ A;  3CZJ A;  3IAP A;  4TTG A;  4F13 A;  1NSV A;  2WMF A;  3NJX A;  4F10 A;  2WMI B;  1N7P A;  1OJM A;  1NSM A;  3DYO A;  1K1Y A;  4D6G A;  1F9G A;  3VDB A;  3VD9 A;  4BZH A;  1RWF A;  1NSX A;  1SNZ A;  3MWX A;  2D73 A;  2CIR A;  4MMH A;  1RWH A;  2WCO A;  3E80 A;  1MMX A;  1EGU A;  1NKG A;  1OJP A;  1ULV A;  1YQ2 A;  3OB8 A;  2WMK A;  1NS0 A;  1JZ6 A;  4OK2 A;  4NEI A;  1L7J A;  1YGA A;  1JOV A;  4D6J A;  4OZW A;  1PX4 A;  3NJV A;  4BZF A;  1JYN A;  1F1S A;  3DCD A;  1K1W A;  1LXK A;  1PX3 A;  3T08 A;  3I3B A;  2WMH A;  5JMD A;  1HN1 A;  1J0N A;  1NS4 A;  1NSZ A;  3J7H A;  4DUW A;  1HM2 A;  4D6F A;  2WW2 A;  3ECQ A;  1W3Y A;  3A24 A;  3VSM A;  2WZS A;  4E1Y A;  1NSR A;  1RW9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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