1HMWA

Active site of chondroitinase ac lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis
Total Genus 236
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
236
sequence length
674
structure length
674
Chain Sequence
GTAELIMKRVMLDLKKPLRNMDKVAEKNLNTLQPDGSWKDVPYKDDAMTNWLPNNHLLQLETIIQAYIEKDSHYYGDDKVFDQISKAFKYWYDSDPKSRNWWHNEIATPQALGEMLILMRYGKKPLDEALVHKLTERMKRGEPEKKTGANKTDIALHYFYRALLTSDEALLSFAVKELFYPVQFVHYEEGLQYDYSYLQHGPQLQISSYGAVFITGVLKLANYVRDTPYALSTEKLAIFSKYYRDSYLKAIRGSYMDFNVEGRGVSRPDILNKKAEKKRLLVAKMIDLKHTEEWADAIARTDSTVAAGYKIEPYHHQFWNGDYVQHLRPAYSFNVRMVSKRTRRSESGNKENLLGRYLSDGATNIQLRGPEYYNIMPVWEWDKIPGITSRDYLTDRPLTKLWGEQGSNDFAGGVSDGVYGASAYALDYDSLQAKKAWFFFDKEIVCLGAGINSNAPENITTTLNQSWLNGPVISTAGKTGRGKITTFKAQGQFWLLHDAIGYYFPEGANLSLSTQSQKGNWFHINNSHSKDEVSGDVFKLWINHGARPENAQYAYIVLPGINKPEEIKKYNGTAPKVLANTNQLQAVYHQQLDMVQAIFYTAGKLSVAGIEIETDKPCAVLIKHINGKQVIWAADPLQKEKTAVLSIRDLKTGKTNRVKIDFPQQEFAGATVEL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis.
pubmed doi rcsb
source organism Pedobacter heparinus
molecule tags Lyase
molecule keywords CHONDROITINASE AC
total genus 236
structure length 674
sequence length 674
ec nomenclature ec 4.2.2.5: Chondroitin AC lyase.
pdb deposition date 2000-12-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02278 Lyase_8 Polysaccharide lyase family 8, super-sandwich domain
A PF02884 Lyase_8_C Polysaccharide lyase family 8, C-terminal beta-sandwich domain
A PF08124 Lyase_8_N Polysaccharide lyase family 8, N terminal alpha-helical domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.50.10.100 Mainly Alpha Alpha/alpha barrel Glycosyltransferase Chondroitin AC/alginate lyase 1hmwA01
2.60.220.10 Mainly Beta Sandwich Chondroitinase Ac; Chain A, domain 3 Polysaccharide lyase family 8-like, C-terminal 1hmwA03
2.70.98.10 Mainly Beta Distorted Sandwich Beta-galactosidase; Chain A, domain 5 Beta-galactosidase; Chain A, domain 5 1hmwA02
1RWAA 2BRVX 1K1XA 4OZVA 1JZ4A 1HN1A 1MMXA 1C82A 2JKEA 1HM3A 1HV6A 4D6FA 3VD7A 2WCOA 1NS7A 3WFAA 1ULVA 1RW9A 3VSNA 3VD3A 3VDAA 5JMFA 4DUXA 2WDAA 1MMZA 1OJOA 2JKPA 4OZWA 1PX4A 4D6HA 1QAZA 3E80A 1NSSA 2WMIA 1UG9A 3OS7A 4E1YA 1NSRA 4RNLA 2D73A 2BRPA 3T0AA 1L7JA 1EGUA 1RWHA 1NSVA 1JZ6A 3I3BA 1JZ5A 4BZFA 1LF6A 1I8QA 1HM2A 1RWGA 1F1SA 1X1IA 3DYMA 3DCDA 3NREA 1JOVA 3DYOA 3T09A 3A24A 4OJZA 1F9GA 1LF9A 1SNZA 1NS0A 3BGAA 1HMUA 2WW0A 3ECQA 3Q1NA 3IMHA 1LXKA 2WMFA 1YQ2A 3OB8A 1JYXA 1MN0A 1NS8A 1OJPA 1N7OA 2FUTA 1L7KA 2WMHA 3I3EA 2CIQA 3VDBA 1NSXA 1N7NA 4FNVA 3I3DA 2WVXA 2CIRA 1LOHA 3K25A 3T0DA 3CZJA 2E24A 3SEPA 3NNBA 3T2OA 1JZ8A 2WW3A 1YGAA 4AQ0A 1JYNA 3MWXA 1DP0A 4TTGA 1RWFA 4D71A 1W3YA 1X1HA 1NSZA 2ZQ0A 4DUWA 4BZGA 2HTBA 1HN0A 4D6GA 1F4HA 4DUVA 4D6JA 2WW2A 3MUZ1 4OK2A 4D6IA 4D72A 1JYWA 1HMWA 1LURA 1Z45A 3T0BA 3J7HA 1OJMA 1N7RA 1K1YA 2WW1A 2X03A 2Q1FA 3VSMA 3NJXA 3VDCA 1RWCA 4BZEA 3MV01 3IAQA 3E7JA 3DECA 2WMJA 3MV11 3T2PA 1J0NA 1JZ3A 1NSUA 2WVYA 1SO0A 2JKAA 1N7PA 3A0OA 4F10A 4F13A 2WMIB 4D6DA 1PX3A 3NJVA 2E22A 4NEIA 4D6EA 1LXMA 5A1AA 4MMIA 1N7QA 1X1JA 3MUY1 3VD4A 2XHNA 3DYPA 2ZXQA 3E1F1 2WZSA 2WMKA 1MMUA 2HTAA 2BRWA 1NKGA 4BZHA 5E1QA 3OBAA 3T08A 1JZ7A 5JMDA 4OK4A 3IAPA 1NS4A 1NS2A 3VD5A 1F4AA 4MMHA 3VD9A 1CB8A 1OJNA 1MMYA 3AFLA 1NSMA 2CISA 2XSGA 1J0MA 1K1WA 1JZ2A 1JYVA 3T2QA 2WMGA 2FUQA 3NFVA 2WVXB 2WVZA 4D6CA 1TXKA
chains in the Genus database with same CATH superfamily
2F6DA 1RWAA 1WMPA 2BB5A 3Q75B 3S4DA 1N4PB 1JZ4A 3WA2X 1H37A 3DSWB 2JKEA 1W6GA 1HM3A 4FXKB 1K72A 2JG0A 2FV0A 3VD7A 3Q78B 1FO2A 1GLMA 4QT9A 3VSNA 4DI5A 3VD3A 1O5MB 2AFAA 3S4BA 3VDAA 2RDYA 5FO9B 1FBOA 4DUXA 3EZ8A 1N95B 5MEHA 3M7CA 3PYAA 1W6KA 4D6HA 4YDEB 1N4SB 2F7QA 1QAZA 2V8KA 4KFDA 2ZISB 3WIWA 3K7XA 1IVUA 3P2CA 5IK9A 1XWTA 1IVXA 1LVNA 2D73A 1G87A 2YX9A 1EGUA 1QWNA 1FT1B 3H7LA 4FNTA 2FUZA 3SDRA 1SQCA 3D51A 4BZFA 4FJQA 2OQEA 3E37B 3DCDA 3NREA 2XN2A 3A24A 1LTXB 1HMUA 2B39A 3Q7FB 1C3DA 1H14A 3OXUA 1LXKA 2WMFA 3ECQA 3EJQA 4EL8A 3TF4A 1YQ2A 4Q2BA 1OJPA 3VW5A 2WMHA 3I3EA 1QAFA 2BT3A 3W7WA 2DROA 3HIIA 1WU4A 3ANIA 4CJ0A 2W0QA 3K25A 5GW7A 3E6UA 2CWVA 3SEPA 1O6QA 5IKHA 4BTYA 3W5NA 1YGAA 1GAIA 5IK0A 1R34A 1AV4A 1DP0A 3PZ3B 4Z4LA 3DX4A 3HXDB 1FMIA 3QT9A 4BZGA 1HN0A 5IL3A 1W6CA 3U7VA 3X3YA 3T0UA 1KSDA 5ILDA 1TN6B 4ZG8A 3N9HA 1KZOB 3QSPA 1QBQB 1WMNA 1JYWA 4EHMB 1L1YA 1HXKA 1Z45A 1OJMA 2VN7A 2H6GB 3HXCB 4BZEA 3RSYA 3MV01 2WOFA 1QWUA 3KQ4A 4L0GA 3DRAB 2OW6A 1GHQA 1J0NA 4DOEA 3CV5A 1SO0A 5CD2A 2WMIB 4F13A 3PYBA 3GT5A 1H12A 3QT3A 4NEIA 2CG0A 1N1BA 4MMIA 1N7QA 3VD4A 3MUY1 2GZ6A 5AGDA 5ILYA 2WZSA 4KKJA 1N9EA 3SQCA 2ZL8A 4LNGB 3WIQA 3CIHA 3WC3A 2WMKA 2CFDA 1IQYA 2HTAA 2BRWA 3DX0A 1QQFA 2WY7A 2ZZRA 3IAPA 3VD5A 4MMHA 1GXOA 4C1SA 3P5RA 3PZ1B 3QR8A 3Q79B 4EV5A 3NFVA 5FO7B 3BUDA 4D6CA 3D5RA 5JPMB 1TXKA 1W4NA 1GXMA 1N23A 3BVVA 2BRVX 4BTWA 2V3NA 3CU7A 2J5CA 3W7UA 2EACA 2V8IA 1K1XA 1SPUA 3EJUA 4KFFA 4D4AA 1HN1A 3BUBA 3P5PA 1C82A 1V7VA 3BS6A 2IEJB 3BVXA 2XWBB 3KLSA 4D4DA 4D6FA 1KSIA 3F59A 2WCOA 3PMMA 2Y74A 1H3BA 2ONGA 2RI8A 1FO3A 2EADA 3M7EA 2G02A 1O1SB 4ZH1A 3Q73B 3WKFA 3HI7A 2BEDB 4AYRA 5KKBA 3SX1A 1NSSA 1TQUA 3QWTA 3BVUA 1TF4A 1GXNA 5DGRA 3D50A 3QDEA 4V1SA 3SFYB 1NSRA 1W5ZA 4D1IA 3MPHA 4RNQA 1JZ6A 3EJSA 3T33A 5ILZA 1HM2A 1I8QA 3ALAA 1F1SA 3HXEB 4AYQA 4CJ1A 4V1RA 2PMVA 1SNZA 2BBCA 2V8JA 1NS0A 2RGKA 3E32B 2OQEC 3Q1NA 3IMHA 1R76A 4GTVB 5JPNB 1JYXA 1MN0A 1NS8A 1CLCA 5EATA 1DCEB 3KBTC 2CIQA 3MUZ1 1N7NA 4FNVA 2BB6A 3I3DA 3PGBA 3WKGA 1KKTA 3W5MA 3DSXB 3T2OA 3GLYA 1V7XA 3QPFA 3MWXA 4TTGA 2XQWA 2F1AA 1S63B 4Q88A 1V7WA 2V3PA 4AYOA 3QXFA 2D5JA 3S9VA 1D8DB 3EUVB 1UMPA 2GH4A 4MBGB 1TN7B 4OK2A 1MZCB 4D4CA 5FO8B 4D6IA 1QAKA 2E2UA 1RJOA 1N4QB 3EJPA 1K1YA 1QALA 2YFOA 3LZ9A 3PZ2B 1SIHA 2OW7A 1JS4A 1SA5B 2G0DA 1H36A 2NVPA 1DOGA 3DECA 1N21A 1US1A 2RI9A 2WVYA 1H39A 3DX3A 1D8EB 5KBPA 5M7YA 4Z4JA 4F10A 4D6DA 2A8ZA 2PN5A 1TQTA 4LNVA 2F1BA 4FUSA 3NJVA 1WMOA 4D6EA 2FBAA 2E2VA 1LXMA 4YDOB 2OOVC 1H54A 2ZXQA 3E1F1 5DHKA 4M76A 1X81B 1MMUA 3M74A 1NKGA 3SFXB 1SIIA 1JCSB 3T08A 1H13A 1NS2A 1F4AA 1CB8A 1OJNA 1NSMA 2CG1A 3H3KA 1KZPB 2DRQA 2FYVA 1JYVA 2WOHA 4GTTB 3W7SA 2DRSA 1W6JA 1KS8A 5IL8A 3BVTA 1CEMA 2FUQA 2WVXB 1FAEA 2WO0A 5ILJA 3QXQA 3X40A 2F0YB 1NL4B 1XW2A 4OZVA 3TY1A 3VXDA 1X9DA 4KTRA 2F7OA 1MMXA 2F7PA 4BOKA 1HCUA 3RX7A 1UI8A 3E33B 1G9GA 1TQWA 3SDVA 3PZ4B 3DX1A 2OKXA 1TNZB 3ANKA 3C72B 3D5SA 3BUQA 1KSCA 2C11A 2DRRA 3E73A 5JMFA 2JKPA 4DLOA 1OJOA 4OZWA 1PX4A 1FBWA 3GZKA 2H6FB 3M00A 3E80A 3LVTA 1TU5A 1V5DA 2WMIA 3RX5A 4BTXA 4EV2A 2Y73A 1IU7A 2WYIA 4RNLA 2BRPA 2SQCA 2CFKA 3DPYB 1RWHA 2WIIB 1NSVA 3ACTA 3I3BA 1JZ5A 1F9DA 4KFEA 2WYHA 4D94A 1LF6A 1N1ZA 1RWGA 1X1IA 3DYMA 1WU5A 1JOVA 4LIXA 3DSTB 1LF9A 4OJZA 1N4RB 2CWUA 3KSQB 2WW0A 3NBJA 3M75A 3DX2A 3RRSA 4DODA 3OB8A 2CFLA 1IVVA 2YFNA 2H6HB 1L7KA 5IK6A 3RX8A 4J5TA 1NSXA 3VDBA 1H3AA 1TNOB 1QSJA 1G6IA 1LOHA 3UD1A 2CIRA 4GTRB 2R2LB 2E24A 5CA3A 3NNBA 1JZ8A 1N24A 1HWWA 2WW3A 4FNQA 3X3XA 5GZKA 3KN4A 2B4FA 5IKAA 2YIKA 1RWFA 3BLCA 3SDQA 4FNRA 4YCRA 1S64B 1NSZA 2E2TA 3AMOA 1WU6A 1A2VA 3AFJA 4D6GA 5FOBB 1PU4A 2ZIRB 5ILKA 3BLBA 2A73B 3EQAA 3X17A 3KBUC 1N9AB 2VN4A 1HMWA 1TQVA 4FNPA 3T0BA 3J7HA 1N7RA 5CZLA 2Q1FA 1O6HA 4DLQA 1W2ZA 2XFGA 3NJXA 3VDCA 1RWCA 1JCRB 3H2WA 2CQSA 5DHIA 1IS9A 2WGQA 3IAQA 2QNOA 3WUXA 3MV11 2WMJA 3M77A 5M7IA 4MU9A 1HTYA 3E30B 2ALWA 3M7LA 3NBBA 1NSUA 1JZ3A 1AYXA 1JCQB 2H6IB 2JKAA 1NXCA 1O6RA 3DSUB 3DSVB 1N7PA 4WU0A 1PX3A 2OOVA 4KTPA 4AYPA 1UI7A 1IQXA 1X1JA 2KXSA 3QG0A 4ZRQA 1KFGA 4D1JA 1GA2A 5E2JA 3X3ZA 5GY3A 3AMOB 4BZHA 5E1QA 4TXTA 4KKIA 5JMDA 4OK4A 1NS4A 1N22A 3M7BA 1R33A 2CFGA 2XSGA 1GAHA 4GTQB 3AFLA 4BOJA 2CISA 3QFZA 3CZNA 3N0GA 3SDTA 2C10A 3HXFB 1TQSA 3T2QA 3X41A 5EASA 2AHFA 3G4FA 1KRFA 3DDGA 1F9OA 3DDFA 4L6XA 1KREA 1HXGA 3EU5B 5EAUA 4K35A 1HV6A 3ANJA 3EJTA 1FPPB 1H35A 1HXCA 1NS7A 1QX1A 3QFYA 1ULVA 1EKMA 1RW9A 3WFAA 1OACA 1TN8B 3N0FA 1TNBB 2WDAA 1MMZA 4ZRPA 2WINB 5IM1A 5ILIA 1DL2A 1WZZA 2F18A 4WVBA 3G6JB 3M78A 4ONTA 3A3VA 3BUIA 1UG9A 2WY8A 3PQIA 3OS7A 1LD8B 5DGQA 1KWFA 4E1YA 2CWTA 1AGMA 3T0AA 3M01A 1L7JA 4XUVA 3EU8A 3LOYA 2Z07A 3BVWA 3KIIA 3M73A 4L9PB 3M02A 3D3IA 3DYOA 3T09A 3D52A 2D1WA 1F9GA 3E34B 1TNUB 1IA6A 3WKIA 3K11A 3BGAA 3D4ZA 3X42A 1FCEA 2F7RA 4GAXA 1N7OA 2EABA 2FUTA 1HXAA 1AVKA 1O1RB 2P0VA 2WVXA 1SA4B 4LNBB 2CQTA 3T0DA 3CZJA 1XWQA 1L2AA 1D6UA 4ZH5A 2CFWA 4AQ0A 1JYNA 4K3AA 3HXBB 2JJBA 2ONHA 1D6ZA 3SAEA 4D71A 1W3YA 1W7CA 3SXXA 1X1HA 2GOXA 2XWJB 2PNCA 2ZQ0A 4DUWA 3OEDA 4GTOB 4GTMB 1IVWA 2HTBA 1F4HA 4DUVA 1VD5A 2AHGA 4D6JA 4WVCA 2WW2A 1PS3A 3RJ3A 4D72A 5C05A 1O1TB 2JF4A 3WKHA 1LURA 1D6YA 2WW1A 1RKYA 2X03A 3G4DA 1UT9A 3VSMA 4FXGB 4GTSB 4UFCA 3HIGA 3M76A 4GTPB 3E7JA 4JJJA 3ON6A 3T2PA 2EAEA 2I07B 3UD2A 3ACSA 5ILHA 1FP3A 1NI1B 3M71A 3DSSB 1H3CA 3W7XA 2XN1A 1GSZA 3A0OA 3WIRA 1HX9A 1RQ5A 1TNYB 2E22A 2XN0A 1N94B 2NOJA 1FT2B 3SDUA 2D8LA 2FV1A 1N20A 1IA7A 3KSLB 5A1AA 1AVLA 2XHNA 3RENA 3DYPA 3QRYA 1LD7B 1V5CA 3S4AA 1NC5A 2WYNA 2KXRA 3S4CA 3BUPA 3WA3A 4GL3A 3W7TA 2ZBLA 4FNUA 3WVFA 1HZFA 4WVAA 3OBAA 1JZ7A 4D4BA 3CZSA 4CE7A 3K5TA 4D8OA 1JZ2A 1MMYA 3VD9A 3D4YA 1J0MA 1K1WA 4FNSA 1JRQA 3MI6A 4TF4A 3EJRA 3Q7AB 3M72A 2WMGA 1G9JA 2WVZA 1O79A 1O7DD 1DYUA
chains in the Genus database with same CATH topology
1RWAA 2BRVX 1K1XA 4OZVA 3TY1A 1JZ4A 1HN1A 1MMXA 1C82A 3BS6A 2JKEA 1HM3A 1HV6A 4D6FA 3VD7A 2WCOA 1NS7A 3WFAA 1ULVA 1RW9A 3VSNA 3VD3A 3VDAA 5JMFA 4DUXA 2WDAA 1MMZA 1OJOA 2JKPA 4OZWA 1PX4A 4D6HA 1QAZA 3E80A 1NSSA 2WMIA 1UG9A 3OS7A 4E1YA 1NSRA 4RNLA 2D73A 2BRPA 3T0AA 1L7JA 1EGUA 1RWHA 1NSVA 1JZ6A 3I3BA 1JZ5A 4BZFA 1LF6A 1I8QA 1HM2A 1RWGA 1F1SA 1X1IA 3DYMA 3DCDA 3NREA 1JOVA 3DYOA 3T09A 3A24A 4OJZA 1F9GA 1LF9A 1SNZA 1NS0A 3BGAA 1HMUA 2WW0A 3ECQA 3Q1NA 3IMHA 1LXKA 2WMFA 1YQ2A 3OB8A 1JYXA 1MN0A 1NS8A 1OJPA 1N7OA 2FUTA 1L7KA 2WMHA 3I3EA 2CIQA 4J5TA 1NSXA 3VDBA 1N7NA 4FNVA 3I3DA 2WVXA 2CIRA 1LOHA 3K25A 3T0DA 3CZJA 2E24A 3SEPA 3NNBA 3T2OA 1JZ8A 2WW3A 1YGAA 4AQ0A 1JYNA 3MWXA 1DP0A 4TTGA 1RWFA 3BLCA 4D71A 1W3YA 1X1HA 1NSZA 2ZQ0A 4DUWA 4BZGA 2HTBA 1HN0A 4D6GA 1F4HA 4DUVA 4D6JA 2WW2A 3MUZ1 4OK2A 4D6IA 4D72A 1JYWA 1HMWA 1LURA 1Z45A 3T0BA 3J7HA 1OJMA 1N7RA 1K1YA 2WW1A 2X03A 2Q1FA 3VSMA 3NJXA 3VDCA 1RWCA 4BZEA 3MV01 3IAQA 3E7JA 3DECA 2WMJA 3MV11 3T2PA 1J0NA 1JZ3A 1NSUA 2WVYA 1SO0A 2JKAA 1N7PA 3A0OA 4F10A 4F13A 2WMIB 4D6DA 1PX3A 3NJVA 2E22A 4NEIA 4D6EA 1LXMA 5A1AA 4MMIA 1N7QA 1X1JA 3MUY1 3VD4A 2XHNA 3DYPA 2ZXQA 3E1F1 2WZSA 2WMKA 1MMUA 2HTAA 2BRWA 1NKGA 3WVFA 4BZHA 5E1QA 3OBAA 3T08A 1JZ7A 5JMDA 4OK4A 3IAPA 1NS4A 1NS2A 3VD5A 1F4AA 4MMHA 3VD9A 1CB8A 1OJNA 1MMYA 3AFLA 1NSMA 2CISA 2XSGA 1J0MA 1K1WA 1JZ2A 1JYVA 3T2QA 2WMGA 2FUQA 3NFVA 2WVXB 2WVZA 4D6CA 1TXKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RWA A;  2BRV X;  1K1X A;  4OZV A;  1JZ4 A;  1HN1 A;  1MMX A;  1C82 A;  2JKE A;  1HM3 A;  1HV6 A;  4D6F A;  3VD7 A;  2WCO A;  1NS7 A;  3WFA A;  1ULV A;  1RW9 A;  3VSN A;  3VD3 A;  3VDA A;  5JMF A;  4DUX A;  2WDA A;  1MMZ A;  1OJO A;  2JKP A;  4OZW A;  1PX4 A;  4D6H A;  1QAZ A;  3E80 A;  1NSS A;  2WMI A;  1UG9 A;  3OS7 A;  4E1Y A;  1NSR A;  4RNL A;  2D73 A;  2BRP A;  3T0A A;  1L7J A;  1EGU A;  1RWH A;  1NSV A;  1JZ6 A;  3I3B A;  1JZ5 A;  4BZF A;  1LF6 A;  1I8Q A;  1HM2 A;  1RWG A;  1F1S A;  1X1I A;  3DYM A;  3DCD A;  3NRE A;  1JOV A;  3DYO A;  3T09 A;  3A24 A;  4OJZ A;  1F9G A;  1LF9 A;  1SNZ A;  1NS0 A;  3BGA A;  1HMU A;  2WW0 A;  3ECQ A;  3Q1N A;  3IMH A;  1LXK A;  2WMF A;  1YQ2 A;  3OB8 A;  1JYX A;  1MN0 A;  1NS8 A;  1OJP A;  1N7O A;  2FUT A;  1L7K A;  2WMH A;  3I3E A;  2CIQ A;  3VDB A;  1NSX A;  1N7N A;  4FNV A;  3I3D A;  2WVX A;  2CIR A;  1LOH A;  3K25 A;  3T0D A;  3CZJ A;  2E24 A;  3SEP A;  3NNB A;  3T2O A;  1JZ8 A;  2WW3 A;  1YGA A;  4AQ0 A;  1JYN A;  3MWX A;  1DP0 A;  4TTG A;  1RWF A;  4D71 A;  1W3Y A;  1X1H A;  1NSZ A;  2ZQ0 A;  4DUW A;  4BZG A;  2HTB A;  1HN0 A;  4D6G A;  1F4H A;  4DUV A;  4D6J A;  2WW2 A;  3MUZ 1;  4OK2 A;  4D6I A;  4D72 A;  1JYW A;  1HMW A;  1LUR A;  1Z45 A;  3T0B A;  3J7H A;  1OJM A;  1N7R A;  1K1Y A;  2WW1 A;  2X03 A;  2Q1F A;  3VSM A;  3NJX A;  3VDC A;  1RWC A;  4BZE A;  3MV0 1;  3IAQ A;  3E7J A;  3DEC A;  2WMJ A;  3MV1 1;  3T2P A;  1J0N A;  1JZ3 A;  1NSU A;  2WVY A;  1SO0 A;  2JKA A;  1N7P A;  3A0O A;  4F10 A;  4F13 A;  2WMI B;  4D6D A;  1PX3 A;  3NJV A;  2E22 A;  4NEI A;  4D6E A;  1LXM A;  5A1A A;  4MMI A;  1N7Q A;  1X1J A;  3MUY 1;  3VD4 A;  2XHN A;  3DYP A;  2ZXQ A;  3E1F 1;  2WZS A;  2WMK A;  1MMU A;  2HTA A;  2BRW A;  1NKG A;  4BZH A;  5E1Q A;  3OBA A;  3T08 A;  1JZ7 A;  5JMD A;  4OK4 A;  3IAP A;  1NS4 A;  1NS2 A;  3VD5 A;  1F4A A;  4MMH A;  3VD9 A;  1CB8 A;  1OJN A;  1MMY A;  3AFL A;  1NSM A;  2CIS A;  2XSG A;  1J0M A;  1K1W A;  1JZ2 A;  1JYV A;  3T2Q A;  2WMG A;  2FUQ A;  3NFV A;  2WVX B;  2WVZ A;  4D6C A;  1TXK A; 
#chains in the Genus database with same CATH topology
 2F6D A;  1RWA A;  1WMP A;  2BB5 A;  3Q75 B;  3S4D A;  1N4P B;  1JZ4 A;  3WA2 X;  1H37 A;  3DSW B;  2JKE A;  1W6G A;  1HM3 A;  4FXK B;  1K72 A;  2JG0 A;  2FV0 A;  3VD7 A;  3Q78 B;  1FO2 A;  1GLM A;  4QT9 A;  3VSN A;  4DI5 A;  3VD3 A;  1O5M B;  2AFA A;  3S4B A;  3VDA A;  2RDY A;  5FO9 B;  1FBO A;  4DUX A;  3EZ8 A;  1N95 B;  5MEH A;  3M7C A;  3PYA A;  1W6K A;  4D6H A;  4YDE B;  1N4S B;  2F7Q A;  1QAZ A;  2V8K A;  4KFD A;  2ZIS B;  3WIW A;  3K7X A;  1IVU A;  3P2C A;  5IK9 A;  1XWT A;  1IVX A;  1LVN A;  2D73 A;  1G87 A;  2YX9 A;  1EGU A;  1QWN A;  1FT1 B;  3H7L A;  4FNT A;  2FUZ A;  3SDR A;  1SQC A;  3D51 A;  4BZF A;  4FJQ A;  2OQE A;  3E37 B;  3DCD A;  3NRE A;  2XN2 A;  3A24 A;  1LTX B;  1HMU A;  2B39 A;  3Q7F B;  1C3D A;  1H14 A;  3OXU A;  1LXK A;  2WMF A;  3ECQ A;  3EJQ A;  4EL8 A;  3TF4 A;  1YQ2 A;  4Q2B A;  1OJP A;  3VW5 A;  2WMH A;  3I3E A;  1QAF A;  2BT3 A;  3W7W A;  2DRO A;  3HII A;  1WU4 A;  3ANI A;  4CJ0 A;  2W0Q A;  3K25 A;  5GW7 A;  3E6U A;  2CWV A;  3SEP A;  1O6Q A;  5IKH A;  4BTY A;  3W5N A;  1YGA A;  1GAI A;  5IK0 A;  1R34 A;  1AV4 A;  1DP0 A;  3PZ3 B;  4Z4L A;  3DX4 A;  3HXD B;  1FMI A;  3QT9 A;  4BZG A;  1HN0 A;  5IL3 A;  1W6C A;  3U7V A;  3X3Y A;  3T0U A;  1KSD A;  5ILD A;  1TN6 B;  4ZG8 A;  3N9H A;  1KZO B;  3QSP A;  1QBQ B;  1WMN A;  1JYW A;  4EHM B;  1L1Y A;  1HXK A;  1Z45 A;  1OJM A;  2VN7 A;  2H6G B;  3HXC B;  4BZE A;  3RSY A;  3MV0 1;  2WOF A;  1QWU A;  3KQ4 A;  4L0G A;  3DRA B;  2OW6 A;  1GHQ A;  1J0N A;  4DOE A;  3CV5 A;  1SO0 A;  5CD2 A;  2WMI B;  4F13 A;  3PYB A;  3GT5 A;  1H12 A;  3QT3 A;  4NEI A;  2CG0 A;  1N1B A;  4MMI A;  1N7Q A;  3VD4 A;  3MUY 1;  2GZ6 A;  5AGD A;  5ILY A;  2WZS A;  4KKJ A;  1N9E A;  3SQC A;  2ZL8 A;  4LNG B;  3WIQ A;  3CIH A;  3WC3 A;  2WMK A;  2CFD A;  1IQY A;  2HTA A;  2BRW A;  3DX0 A;  1QQF A;  2WY7 A;  2ZZR A;  3IAP A;  3VD5 A;  4MMH A;  1GXO A;  4C1S A;  3P5R A;  3PZ1 B;  3QR8 A;  3Q79 B;  4EV5 A;  3NFV A;  5FO7 B;  3BUD A;  4D6C A;  3D5R A;  5JPM B;  1TXK A;  1W4N A;  1GXM A;  1N23 A;  3BVV A;  2BRV X;  4BTW A;  2V3N A;  3CU7 A;  2J5C A;  3W7U A;  2EAC A;  2V8I A;  1K1X A;  1SPU A;  3EJU A;  4KFF A;  4D4A A;  1HN1 A;  3BUB A;  3P5P A;  1C82 A;  1V7V A;  3BS6 A;  2IEJ B;  3BVX A;  2XWB B;  3KLS A;  4D4D A;  4D6F A;  1KSI A;  3F59 A;  2WCO A;  3PMM A;  2Y74 A;  1H3B A;  2ONG A;  2RI8 A;  1FO3 A;  2EAD A;  3M7E A;  2G02 A;  1O1S B;  4ZH1 A;  3Q73 B;  3WKF A;  3HI7 A;  2BED B;  4AYR A;  5KKB A;  3SX1 A;  1NSS A;  1TQU A;  3QWT A;  3BVU A;  1TF4 A;  1GXN A;  5DGR A;  3D50 A;  3QDE A;  4V1S A;  3SFY B;  1NSR A;  1W5Z A;  4D1I A;  3MPH A;  4RNQ A;  1JZ6 A;  3EJS A;  3T33 A;  5ILZ A;  1HM2 A;  1I8Q A;  3ALA A;  1F1S A;  3HXE B;  4AYQ A;  4CJ1 A;  4V1R A;  2PMV A;  1SNZ A;  2BBC A;  2V8J A;  1NS0 A;  2RGK A;  3E32 B;  2OQE C;  3Q1N A;  3IMH A;  1R76 A;  4GTV B;  5JPN B;  1JYX A;  1MN0 A;  1NS8 A;  1CLC A;  5EAT A;  1DCE B;  3KBT C;  2CIQ A;  3MUZ 1;  1N7N A;  4FNV A;  2BB6 A;  3I3D A;  3PGB A;  3WKG A;  1KKT A;  3W5M A;  3DSX B;  3T2O A;  3GLY A;  1V7X A;  3QPF A;  3MWX A;  4TTG A;  2XQW A;  2F1A A;  1S63 B;  4Q88 A;  1V7W A;  2V3P A;  4AYO A;  3QXF A;  2D5J A;  3S9V A;  1D8D B;  3EUV B;  1UMP A;  2GH4 A;  4MBG B;  1TN7 B;  4OK2 A;  1MZC B;  4D4C A;  5FO8 B;  4D6I A;  1QAK A;  2E2U A;  1RJO A;  1N4Q B;  3EJP A;  1K1Y A;  1QAL A;  2YFO A;  3LZ9 A;  3PZ2 B;  1SIH A;  2OW7 A;  1JS4 A;  1SA5 B;  2G0D A;  1H36 A;  2NVP A;  1DOG A;  3DEC A;  1N21 A;  1US1 A;  2RI9 A;  2WVY A;  1H39 A;  3DX3 A;  1D8E B;  5KBP A;  5M7Y A;  4Z4J A;  4F10 A;  4D6D A;  2A8Z A;  2PN5 A;  1TQT A;  4LNV A;  2F1B A;  4FUS A;  3NJV A;  1WMO A;  4D6E A;  2FBA A;  2E2V A;  1LXM A;  4YDO B;  2OOV C;  1H54 A;  2ZXQ A;  3E1F 1;  5DHK A;  4M76 A;  1X81 B;  1MMU A;  3M74 A;  1NKG A;  3SFX B;  1SII A;  1JCS B;  3T08 A;  1H13 A;  1NS2 A;  1F4A A;  1CB8 A;  1OJN A;  1NSM A;  2CG1 A;  3H3K A;  1KZP B;  2DRQ A;  2FYV A;  1JYV A;  2WOH A;  4GTT B;  3W7S A;  2DRS A;  1W6J A;  1KS8 A;  5IL8 A;  3BVT A;  1CEM A;  2FUQ A;  2WVX B;  1FAE A;  2WO0 A;  5ILJ A;  3QXQ A;  3X40 A;  2F0Y B;  1NL4 B;  1XW2 A;  4OZV A;  3TY1 A;  3VXD A;  1X9D A;  4KTR A;  2F7O A;  1MMX A;  2F7P A;  4BOK A;  1HCU A;  3RX7 A;  1UI8 A;  3E33 B;  1G9G A;  1TQW A;  3SDV A;  3PZ4 B;  3DX1 A;  2OKX A;  1TNZ B;  3ANK A;  3C72 B;  3D5S A;  3BUQ A;  1KSC A;  2C11 A;  2DRR A;  3E73 A;  5JMF A;  2JKP A;  4DLO A;  1OJO A;  4OZW A;  1PX4 A;  1FBW A;  3GZK A;  2H6F B;  3M00 A;  3E80 A;  3LVT A;  1TU5 A;  1V5D A;  2WMI A;  3RX5 A;  4BTX A;  4EV2 A;  2Y73 A;  1IU7 A;  2WYI A;  4RNL A;  2BRP A;  2SQC A;  2CFK A;  3DPY B;  1RWH A;  2WII B;  1NSV A;  3ACT A;  3I3B A;  1JZ5 A;  1F9D A;  4KFE A;  2WYH A;  4D94 A;  1LF6 A;  1N1Z A;  1RWG A;  1X1I A;  3DYM A;  1WU5 A;  1JOV A;  4LIX A;  3DST B;  1LF9 A;  4OJZ A;  1N4R B;  2CWU A;  3KSQ B;  2WW0 A;  3NBJ A;  3M75 A;  3DX2 A;  3RRS A;  4DOD A;  3OB8 A;  2CFL A;  1IVV A;  2YFN A;  2H6H B;  1L7K A;  5IK6 A;  3RX8 A;  4J5T A;  1NSX A;  3VDB A;  1H3A A;  1TNO B;  1QSJ A;  1G6I A;  1LOH A;  3UD1 A;  2CIR A;  4GTR B;  2R2L B;  2E24 A;  5CA3 A;  3NNB A;  1JZ8 A;  1N24 A;  1HWW A;  2WW3 A;  4FNQ A;  3X3X A;  5GZK A;  3KN4 A;  2B4F A;  5IKA A;  2YIK A;  1RWF A;  3BLC A;  3SDQ A;  4FNR A;  4YCR A;  1S64 B;  1NSZ A;  2E2T A;  3AMO A;  1WU6 A;  1A2V A;  3AFJ A;  4D6G A;  5FOB B;  1PU4 A;  2ZIR B;  5ILK A;  3BLB A;  2A73 B;  3EQA A;  3X17 A;  3KBU C;  1N9A B;  2VN4 A;  1HMW A;  1TQV A;  4FNP A;  3T0B A;  3J7H A;  1N7R A;  5CZL A;  2Q1F A;  1O6H A;  4DLQ A;  1W2Z A;  2XFG A;  3NJX A;  3VDC A;  1RWC A;  1JCR B;  3H2W A;  2CQS A;  5DHI A;  1IS9 A;  2WGQ A;  3IAQ A;  2QNO A;  3WUX A;  3MV1 1;  2WMJ A;  3M77 A;  5M7I A;  4MU9 A;  1HTY A;  3E30 B;  2ALW A;  3M7L A;  3NBB A;  1NSU A;  1JZ3 A;  1AYX A;  1JCQ B;  2H6I B;  2JKA A;  1NXC A;  1O6R A;  3DSU B;  3DSV B;  1N7P A;  4WU0 A;  1PX3 A;  2OOV A;  4KTP A;  4AYP A;  1UI7 A;  1IQX A;  1X1J A;  2KXS A;  3QG0 A;  4ZRQ A;  1KFG A;  4D1J A;  1GA2 A;  5E2J A;  3X3Z A;  5GY3 A;  3AMO B;  4BZH A;  5E1Q A;  4TXT A;  4KKI A;  5JMD A;  4OK4 A;  1NS4 A;  1N22 A;  3M7B A;  1R33 A;  2CFG A;  2XSG A;  1GAH A;  4GTQ B;  3AFL A;  4BOJ A;  2CIS A;  3QFZ A;  3CZN A;  3N0G A;  3SDT A;  2C10 A;  3HXF B;  1TQS A;  3T2Q A;  3X41 A;  5EAS A;  2AHF A;  3G4F A;  1KRF A;  3DDG A;  1F9O A;  3DDF A;  4L6X A;  1KRE A;  1HXG A;  3EU5 B;  5EAU A;  4K35 A;  1HV6 A;  3ANJ A;  3EJT A;  1FPP B;  1H35 A;  1HXC A;  1NS7 A;  1QX1 A;  3QFY A;  1ULV A;  1EKM A;  1RW9 A;  3WFA A;  1OAC A;  1TN8 B;  3N0F A;  1TNB B;  2WDA A;  1MMZ A;  4ZRP A;  2WIN B;  5IM1 A;  5ILI A;  1DL2 A;  1WZZ A;  2F18 A;  4WVB A;  3G6J B;  3M78 A;  4ONT A;  3A3V A;  3BUI A;  1UG9 A;  2WY8 A;  3PQI A;  3OS7 A;  1LD8 B;  5DGQ A;  1KWF A;  4E1Y A;  2CWT A;  1AGM A;  3T0A A;  3M01 A;  1L7J A;  4XUV A;  3EU8 A;  3LOY A;  2Z07 A;  3BVW A;  3KII A;  3M73 A;  4L9P B;  3M02 A;  3D3I A;  3DYO A;  3T09 A;  3D52 A;  2D1W A;  1F9G A;  3E34 B;  1TNU B;  1IA6 A;  3WKI A;  3K11 A;  3BGA A;  3D4Z A;  3X42 A;  1FCE A;  2F7R A;  4GAX A;  1N7O A;  2EAB A;  2FUT A;  1HXA A;  1AVK A;  1O1R B;  2P0V A;  2WVX A;  1SA4 B;  4LNB B;  2CQT A;  3T0D A;  3CZJ A;  1XWQ A;  1L2A A;  1D6U A;  4ZH5 A;  2CFW A;  4AQ0 A;  1JYN A;  4K3A A;  3HXB B;  2JJB A;  2ONH A;  1D6Z A;  3SAE A;  4D71 A;  1W3Y A;  1W7C A;  3SXX A;  1X1H A;  2GOX A;  2XWJ B;  2PNC A;  2ZQ0 A;  4DUW A;  3OED A;  4GTO B;  4GTM B;  1IVW A;  2HTB A;  1F4H A;  4DUV A;  1VD5 A;  2AHG A;  4D6J A;  4WVC A;  2WW2 A;  1PS3 A;  3RJ3 A;  4D72 A;  5C05 A;  1O1T B;  2JF4 A;  3WKH A;  1LUR A;  1D6Y A;  2WW1 A;  1RKY A;  2X03 A;  3G4D A;  1UT9 A;  3VSM A;  4FXG B;  4GTS B;  4UFC A;  3HIG A;  3M76 A;  4GTP B;  3E7J A;  4JJJ A;  3ON6 A;  3T2P A;  2EAE A;  2I07 B;  3UD2 A;  3ACS A;  5ILH A;  1FP3 A;  1NI1 B;  3M71 A;  3DSS B;  1H3C A;  3W7X A;  2XN1 A;  1GSZ A;  3A0O A;  3WIR A;  1HX9 A;  1RQ5 A;  1TNY B;  2E22 A;  2XN0 A;  1N94 B;  2NOJ A;  1FT2 B;  3SDU A;  2D8L A;  2FV1 A;  1N20 A;  1IA7 A;  3KSL B;  5A1A A;  1AVL A;  2XHN A;  3REN A;  3DYP A;  3QRY A;  1LD7 B;  1V5C A;  3S4A A;  1NC5 A;  2WYN A;  2KXR A;  3S4C A;  3BUP A;  3WA3 A;  4GL3 A;  3W7T A;  2ZBL A;  4FNU A;  3WVF A;  1HZF A;  4WVA A;  3OBA A;  1JZ7 A;  4D4B A;  3CZS A;  4CE7 A;  3K5T A;  4D8O A;  1JZ2 A;  1MMY A;  3VD9 A;  3D4Y A;  1J0M A;  1K1W A;  4FNS A;  1JRQ A;  3MI6 A;  4TF4 A;  3EJR A;  3Q7A B;  3M72 A;  2WMG A;  1G9J A;  2WVZ A;  1O79 A;  1O7D D;  1DYU A; 
#chains in the Genus database with same CATH homology
 1RWA A;  2BRV X;  1K1X A;  4OZV A;  3TY1 A;  1JZ4 A;  1HN1 A;  1MMX A;  1C82 A;  3BS6 A;  2JKE A;  1HM3 A;  1HV6 A;  4D6F A;  3VD7 A;  2WCO A;  1NS7 A;  3WFA A;  1ULV A;  1RW9 A;  3VSN A;  3VD3 A;  3VDA A;  5JMF A;  4DUX A;  2WDA A;  1MMZ A;  1OJO A;  2JKP A;  4OZW A;  1PX4 A;  4D6H A;  1QAZ A;  3E80 A;  1NSS A;  2WMI A;  1UG9 A;  3OS7 A;  4E1Y A;  1NSR A;  4RNL A;  2D73 A;  2BRP A;  3T0A A;  1L7J A;  1EGU A;  1RWH A;  1NSV A;  1JZ6 A;  3I3B A;  1JZ5 A;  4BZF A;  1LF6 A;  1I8Q A;  1HM2 A;  1RWG A;  1F1S A;  1X1I A;  3DYM A;  3DCD A;  3NRE A;  1JOV A;  3DYO A;  3T09 A;  3A24 A;  4OJZ A;  1F9G A;  1LF9 A;  1SNZ A;  1NS0 A;  3BGA A;  1HMU A;  2WW0 A;  3ECQ A;  3Q1N A;  3IMH A;  1LXK A;  2WMF A;  1YQ2 A;  3OB8 A;  1JYX A;  1MN0 A;  1NS8 A;  1OJP A;  1N7O A;  2FUT A;  1L7K A;  2WMH A;  3I3E A;  2CIQ A;  4J5T A;  1NSX A;  3VDB A;  1N7N A;  4FNV A;  3I3D A;  2WVX A;  2CIR A;  1LOH A;  3K25 A;  3T0D A;  3CZJ A;  2E24 A;  3SEP A;  3NNB A;  3T2O A;  1JZ8 A;  2WW3 A;  1YGA A;  4AQ0 A;  1JYN A;  3MWX A;  1DP0 A;  4TTG A;  1RWF A;  3BLC A;  4D71 A;  1W3Y A;  1X1H A;  1NSZ A;  2ZQ0 A;  4DUW A;  4BZG A;  2HTB A;  1HN0 A;  4D6G A;  1F4H A;  4DUV A;  4D6J A;  2WW2 A;  3MUZ 1;  4OK2 A;  4D6I A;  4D72 A;  1JYW A;  1HMW A;  1LUR A;  1Z45 A;  3T0B A;  3J7H A;  1OJM A;  1N7R A;  1K1Y A;  2WW1 A;  2X03 A;  2Q1F A;  3VSM A;  3NJX A;  3VDC A;  1RWC A;  4BZE A;  3MV0 1;  3IAQ A;  3E7J A;  3DEC A;  2WMJ A;  3MV1 1;  3T2P A;  1J0N A;  1JZ3 A;  1NSU A;  2WVY A;  1SO0 A;  2JKA A;  1N7P A;  3A0O A;  4F10 A;  4F13 A;  2WMI B;  4D6D A;  1PX3 A;  3NJV A;  2E22 A;  4NEI A;  4D6E A;  1LXM A;  5A1A A;  4MMI A;  1N7Q A;  1X1J A;  3MUY 1;  3VD4 A;  2XHN A;  3DYP A;  2ZXQ A;  3E1F 1;  2WZS A;  2WMK A;  1MMU A;  2HTA A;  2BRW A;  1NKG A;  3WVF A;  4BZH A;  5E1Q A;  3OBA A;  3T08 A;  1JZ7 A;  5JMD A;  4OK4 A;  3IAP A;  1NS4 A;  1NS2 A;  3VD5 A;  1F4A A;  4MMH A;  3VD9 A;  1CB8 A;  1OJN A;  1MMY A;  3AFL A;  1NSM A;  2CIS A;  2XSG A;  1J0M A;  1K1W A;  1JZ2 A;  1JYV A;  3T2Q A;  2WMG A;  2FUQ A;  3NFV A;  2WVX B;  2WVZ A;  4D6C A;  1TXK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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