1I4LA

Crystal structure analysis of rac1-gdp in complex with arfaptin (p41)
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
201
structure length
185
Chain Sequence
SRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords ARFAPTIN 2
total genus 81
structure length 185
sequence length 201
chains with identical sequence B
ec nomenclature
pdb deposition date 2001-02-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 1i4lA00
1I4DA 2X3XA 2Q13A 2RAIA 2X3VA 4WPCA 3SYVA 4AVMA 5C5BA 3QWEA 3CAZA 4I1QA 4FZSA 4AKVA 1ZWWA 2X3WA 1X03A 2C08A 3I2WA 3LLLA 1URUA 3HAJA 3QE6A 1X04A 2YKTA 3PLTA 3Q84A 3QNIA 5C5BB 4BNEA 2EFLA 2ELBA 2FICA 3ABHA 4ATMA 2Z0VA 2Z0OA 4DCNC 1I4LA 2D1LA 3M3WA 4NQIA 4WPEA 1Y2OA 3Q0KA 2D4CA 2Z0NA 2V0OA 3HAIA 2EFKA 2RAJA 3OK8A 3DYTA 4H8SA 1I49A 1WDZA 3ACOA 3G9GA 3SOGA 2Q12A 4DYLA 1I4TA 2RAKA 4NSWA 3HAHA
chains in the Genus database with same CATH superfamily
1LQ7A 2X3VA 1HWWA 1OAOA 1TQUA 5C5BB 4FZPA 3D50A 4NPHA 4AZCA 4WPEA 1R34A 3I39X 3BVUA 2YIVX 3DPQA 3A98A 1R33A 5E84A 2RAIA 3I01A 3F7WA 1W9MA 4JNFA 1URUA 2LM0A 3DX3A 4IM0A 2YIAA 4R5GA 2Z0NA 2EFKA 4E3CA 2F7PA 3B51X 3EJQA 3LVTA 4EZQA 1OA0A 5KBPA 2ALWA 4EZNA 3EJSA 3BVXA 2EWFA 4EZWA 3PLTA 4ATMA 4IWPA 1I4LA 2D1LA 3CZNA 3T4AG 3DX1A 4R5KA 2JNKA 2OBLA 2YIBA 4KIKB 4IM2A 4NSWA 3HAHA 3DPOA 2QXLA 4I1QA 4AZ6A 1X04A 3Q84A 2EFLA 2ELBA 3DX2A 2OZNB 1GN9A 1O7DC 4R5IA 1OA1A 1GNTA 4IM3A 3EJTA 3QWEA 4JWDA 4JWEA 2YL5A 4JLCA 2FICA 4EZUA 1SU8A 2YLLA 1TQWA 3LMFA 3B53X 3OK8A 3L3OM 3SOGA 1I4DA 2X3XA 2YL6A 4AZIA 2MI7A 3QE6A 2EX3B 4EZPA 1SU6A 3CVRA 3M3WA 4FM3A 2D4CA 2RAJA 4H8SA 4AZ7A 2GF4A 1QWNA 1DKZA 4AVMA 1GNLA 3I2WA 3QNIA 2Z8YA 3D4ZA 3O3OB 2FYVA 3VKHA 4UDXX 3T48A 1YWMA 3D52A 3UITA 4DYLA 1I4TA 1SU7A 3BVWA 5TKYA 1QX1A 2WYIA 2YKTA 1E2UA 3O3MB 2OBMA 2F7OA 4UDYX 1Y2OA 3RV0A 2V0OA 1I49A 4JWIA 3T49A 4AZCB 3RPMA 2YL9A 4HR1A 4JWCA 4AZBA 3ER9B 2JNSA 4M0MA 2Z0VA 3CKDA 4EZSA 4R5JA 2RT6A 1SUFA 2F7QA 4AZHA 3RV1A 3O3NB 4EZXA 4H6IA 4AZGA 4AKVA 3DDFA 3BUQA 3QA8A 4EZZA 3EJRA 5FLEX 3HAIA 3KAVA 2PMRA 1WDZA 3G9GA 3ER8C 3D2FA 3BUIA 2F1AA 2Q13A 1MJGA 3B52X 3DX4A 5FIGA 3EJUA 4HR1B 3VEBA 2LXYA 2Z0OA 4EZTA 2F7RA 3QNJA 1PS3A 3ACOA 2X5CA 3FD9A 3KAWA 3BLBA 3LLLA 1TQTA 4EZOA 2OO2A 2C08A 4E81A 3OHXM 4IWQA 4H6HA 1HTYA 4PO2A 4DCNC 3ERCC 1JQKA 3BUDA 4KIKA 3T46A 2F18A 1QWUA 3Q0KA 3C7NA 1TQSA 2Q12A 3DDGA 2YI9A 3SYVA 4F00A 4IWOA 4FZSA 1UPXA 4D8JA 3BVVA 1ZWWA 1DKYA 1HXKA 1R5EA 4B9QA 4R5LA 1ZYLA 4JN4A 2KHOA 4HYBA 3DYTA 3ZEDA 1DKXA 4JL9A 2GA9D 2YL8A 2OW6A 3L3PA 2X3WA 3D4YA 3BVTA 2PY6A 4EZVA 2O0I1 4FZOA 4G6QA 2F1BA 2YI8A 2NCZA 3DX0A 3I04A 2RAKA 1TQVA 4EZYA 5C5BA 3CAZA 3CZSA 1X03A 3CV5A 3HAJA 4F01A 2ND0A 4JNEA 1E9VA 3GI7A 3ABHA 2YLAA 3T47A 4NQIA 2GAFD 2QKWA 2OW7A 4EZRA 3BUPA 4HY9A 3EJPA 4AZ5A 3KDRA 4WPCA 4IW0A 2ND1A 2N3KA 2WYHA 3OWGA 1O7DB 3VEAA 2WINM 1E1DA 3D51A 3BUBA 1U00A 2QFFA 2ZXQA 3D2EA 4BNEA 3DPPA
chains in the Genus database with same CATH topology
1I4DA 2X3XA 2Q13A 2RAIA 2X3VA 4WPCA 3SYVA 4AVMA 5C5BA 3QWEA 3CAZA 4I1QA 4FZSA 4AKVA 1ZWWA 2X3WA 1X03A 2C08A 3I2WA 3LLLA 1URUA 3HAJA 3QE6A 1X04A 2YKTA 3PLTA 3Q84A 3QNIA 5C5BB 4BNEA 2EFLA 2ELBA 2FICA 3ABHA 4ATMA 2Z0VA 2Z0OA 4DCNC 1I4LA 2D1LA 3M3WA 4NQIA 4WPEA 1Y2OA 3Q0KA 2D4CA 2Z0NA 2V0OA 3HAIA 2EFKA 2RAJA 3OK8A 3DYTA 4H8SA 1I49A 1WDZA 3ACOA 3G9GA 3SOGA 2Q12A 4DYLA 1I4TA 2RAKA 4NSWA 3HAHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I4D A;  2X3X A;  2Q13 A;  2RAI A;  2X3V A;  4WPC A;  3SYV A;  4AVM A;  5C5B A;  3QWE A;  3CAZ A;  4I1Q A;  4FZS A;  4AKV A;  1ZWW A;  2X3W A;  1X03 A;  2C08 A;  3I2W A;  3LLL A;  1URU A;  3HAJ A;  3QE6 A;  1X04 A;  2YKT A;  3PLT A;  3Q84 A;  3QNI A;  5C5B B;  4BNE A;  2EFL A;  2ELB A;  2FIC A;  3ABH A;  4ATM A;  2Z0V A;  2Z0O A;  4DCN C;  1I4L A;  2D1L A;  3M3W A;  4NQI A;  4WPE A;  1Y2O A;  3Q0K A;  2D4C A;  2Z0N A;  2V0O A;  3HAI A;  2EFK A;  2RAJ A;  3OK8 A;  3DYT A;  4H8S A;  1I49 A;  1WDZ A;  3ACO A;  3G9G A;  3SOG A;  2Q12 A;  4DYL A;  1I4T A;  2RAK A;  4NSW A;  3HAH A; 
#chains in the Genus database with same CATH topology
 1LQ7 A;  2X3V A;  1HWW A;  1OAO A;  1TQU A;  5C5B B;  4FZP A;  3D50 A;  4NPH A;  4AZC A;  4WPE A;  1R34 A;  3I39 X;  3BVU A;  2YIV X;  3DPQ A;  3A98 A;  1R33 A;  5E84 A;  2RAI A;  3I01 A;  3F7W A;  1W9M A;  4JNF A;  1URU A;  2LM0 A;  3DX3 A;  4IM0 A;  2YIA A;  4R5G A;  2Z0N A;  2EFK A;  4E3C A;  2F7P A;  3B51 X;  3EJQ A;  3LVT A;  4EZQ A;  1OA0 A;  5KBP A;  2ALW A;  4EZN A;  3EJS A;  3BVX A;  2EWF A;  4EZW A;  3PLT A;  4ATM A;  4IWP A;  1I4L A;  2D1L A;  3CZN A;  3T4A G;  3DX1 A;  4R5K A;  2JNK A;  2OBL A;  2YIB A;  4KIK B;  4IM2 A;  4NSW A;  3HAH A;  3DPO A;  2QXL A;  4I1Q A;  4AZ6 A;  1X04 A;  3Q84 A;  2EFL A;  2ELB A;  3DX2 A;  2OZN B;  1GN9 A;  1O7D C;  4R5I A;  1OA1 A;  1GNT A;  4IM3 A;  3EJT A;  3QWE A;  4JWD A;  4JWE A;  2YL5 A;  4JLC A;  2FIC A;  4EZU A;  1SU8 A;  2YLL A;  1TQW A;  3LMF A;  3B53 X;  3OK8 A;  3L3O M;  3SOG A;  1I4D A;  2X3X A;  2YL6 A;  4AZI A;  2MI7 A;  3QE6 A;  2EX3 B;  4EZP A;  1SU6 A;  3CVR A;  3M3W A;  4FM3 A;  2D4C A;  2RAJ A;  4H8S A;  4AZ7 A;  2GF4 A;  1QWN A;  1DKZ A;  4AVM A;  1GNL A;  3I2W A;  3QNI A;  2Z8Y A;  3D4Z A;  3O3O B;  2FYV A;  3VKH A;  4UDX X;  3T48 A;  1YWM A;  3D52 A;  3UIT A;  4DYL A;  1I4T A;  1SU7 A;  3BVW A;  5TKY A;  1QX1 A;  2WYI A;  2YKT A;  1E2U A;  3O3M B;  2OBM A;  2F7O A;  4UDY X;  1Y2O A;  3RV0 A;  2V0O A;  1I49 A;  4JWI A;  3T49 A;  4AZC B;  3RPM A;  2YL9 A;  4HR1 A;  4JWC A;  4AZB A;  3ER9 B;  2JNS A;  4M0M A;  2Z0V A;  3CKD A;  4EZS A;  4R5J A;  2RT6 A;  1SUF A;  2F7Q A;  4AZH A;  3RV1 A;  3O3N B;  4EZX A;  4H6I A;  4AZG A;  4AKV A;  3DDF A;  3BUQ A;  3QA8 A;  4EZZ A;  3EJR A;  5FLE X;  3HAI A;  3KAV A;  2PMR A;  1WDZ A;  3G9G A;  3ER8 C;  3D2F A;  3BUI A;  2F1A A;  2Q13 A;  1MJG A;  3B52 X;  3DX4 A;  5FIG A;  3EJU A;  4HR1 B;  3VEB A;  2LXY A;  2Z0O A;  4EZT A;  2F7R A;  3QNJ A;  1PS3 A;  3ACO A;  2X5C A;  3FD9 A;  3KAW A;  3BLB A;  3LLL A;  1TQT A;  4EZO A;  2OO2 A;  2C08 A;  4E81 A;  3OHX M;  4IWQ A;  4H6H A;  1HTY A;  4PO2 A;  4DCN C;  3ERC C;  1JQK A;  3BUD A;  4KIK A;  3T46 A;  2F18 A;  1QWU A;  3Q0K A;  3C7N A;  1TQS A;  2Q12 A;  3DDG A;  2YI9 A;  3SYV A;  4F00 A;  4IWO A;  4FZS A;  1UPX A;  4D8J A;  3BVV A;  1ZWW A;  1DKY A;  1HXK A;  1R5E A;  4B9Q A;  4R5L A;  1ZYL A;  4JN4 A;  2KHO A;  4HYB A;  3DYT A;  3ZED A;  1DKX A;  4JL9 A;  2GA9 D;  2YL8 A;  2OW6 A;  3L3P A;  2X3W A;  3D4Y A;  3BVT A;  2PY6 A;  4EZV A;  2O0I 1;  4FZO A;  4G6Q A;  2F1B A;  2YI8 A;  2NCZ A;  3DX0 A;  3I04 A;  2RAK A;  1TQV A;  4EZY A;  5C5B A;  3CAZ A;  3CZS A;  1X03 A;  3CV5 A;  3HAJ A;  4F01 A;  2ND0 A;  4JNE A;  1E9V A;  3GI7 A;  3ABH A;  2YLA A;  3T47 A;  4NQI A;  2GAF D;  2QKW A;  2OW7 A;  4EZR A;  3BUP A;  4HY9 A;  3EJP A;  4AZ5 A;  3KDR A;  4WPC A;  4IW0 A;  2ND1 A;  2N3K A;  2WYH A;  3OWG A;  1O7D B;  3VEA A;  2WIN M;  1E1D A;  3D51 A;  3BUB A;  1U00 A;  2QFF A;  2ZXQ A;  3D2E A;  4BNE A;  3DPP A; 
#chains in the Genus database with same CATH homology
 1I4D A;  2X3X A;  2Q13 A;  2RAI A;  2X3V A;  4WPC A;  3SYV A;  4AVM A;  5C5B A;  3QWE A;  3CAZ A;  4I1Q A;  4FZS A;  4AKV A;  1ZWW A;  2X3W A;  1X03 A;  2C08 A;  3I2W A;  3LLL A;  1URU A;  3HAJ A;  3QE6 A;  1X04 A;  2YKT A;  3PLT A;  3Q84 A;  3QNI A;  5C5B B;  4BNE A;  2EFL A;  2ELB A;  2FIC A;  3ABH A;  4ATM A;  2Z0V A;  2Z0O A;  4DCN C;  1I4L A;  2D1L A;  3M3W A;  4NQI A;  4WPE A;  1Y2O A;  3Q0K A;  2D4C A;  2Z0N A;  2V0O A;  3HAI A;  2EFK A;  2RAJ A;  3OK8 A;  3DYT A;  4H8S A;  1I49 A;  1WDZ A;  3ACO A;  3G9G A;  3SOG A;  2Q12 A;  4DYL A;  1I4T A;  2RAK A;  4NSW A;  3HAH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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