1I72B

Human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and covalently bound 5'-deoxy-5'-[n-methyl-n-(2-aminooxyethyl) amino]adenosine
Total Genus 6
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
6
sequence length
64
structure length
61
Chain Sequence
AHFFEGTEKLLEVWFSRQQPQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN
total genus 6
structure length 61
sequence length 64
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2001-03-07
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.360.50 Alpha Beta 2-Layer Sandwich Dihydrodipicolinate Reductase; domain 2 S-adenosylmethionine decarboxylase 1i72B01
3DZ3B 1I7MB 3EP7B 3EP9B 3EP8B 3EP4B 1I79B 3EPBB 1I7BB 3DZ6B 3DZ2B 1I7CB 1MHMB 1I72B 3EP3B 3DZ5B 1JENB 3H0VB 3EPAB 3DZ7B 3EP5B 3H0WB 3DZ4B 5TVOB 3EP6B
chains in the Genus database with same CATH superfamily
2GYYA 3HJAA 1RYEA 3Q0EA 2OZPA 3NT2A 3EC7A 3EP4B 2G82A 3OHSX 3PZRA 1H2HA 4R54A 3VAZA 3IWCB 5A04A 1YL7A 1MHMB 1DC6A 3M2TA 3DZ5B 1NVMB 3DTYA 3GNQA 1NQ5A 3LC2O 3NTRA 4NHEA 5EINA 1YL5A 3WGOA 1GAEO 4QX6A 4TVBA 3L6OO 4R41A 3EP6B 3PYLA 4L9RA 3V1YA 1P1IA 4LRTB 1I32A 1T4BA 2VYND 2PKQP 1UYJA 5A06A 3PWSA 3CEAA 4O63O 3IDSA 3KV3O 1RYDA 3WGYA 1I7CB 1P1HA 2X5KO 3GPDG 1NWCA 2YV3A 4MKZA 4MVJE 3WB9A 5J9GA 1VM6A 1PS8A 3MOIA 3STHA 1CRWG 3U3XA 3RCBA 1ML3A 1OZAA 1H6AA 5JW6A 1DAPA 1I72B 5EERA 5KVSA 1JENB 1DSSG 1H6BA 4XQEA 4N54A 2DAPA 1ARZA 3PZBA 4MJLA 4MVJF 4ZHSA 4R5HA 4XB2A 4DPMA 3GFGA 3EP7B 3PWKA 1VKNA 3RC9A 3FHLA 3B20A 1TB4A 2HO5A 1IHYA 2Q22A 1RM0A 3TV1A 2CZCA 3B1KA 1E5QA 3RVDA 4XQGA 4R3WA 3QY9A 3NTOA 2R00A 1T4DA 2O4UX 3UW3A 3FD8A 5TVOB 3NT5A 3NTQA 3EZYA 3QVSA 4HKTA 3TW3A 4PG7A 3CINA 1ZNQO 1VC2A 3EUWA 4II7A 3V5NA 2VYVD 3JSAA 4Z0HO 5A02A 4GMGA 1XEAA 3LVFO 1J0XO 1PR3A 1DC3A 4R51A 5EESA 3EP5B 3DAPA 5AVOA 2DBVO 3PYMA 2XF8A 1P9LA 1CERA 3I23A 3ZDFA 2R00C 4MVJM 3WGQA 2I3AA 3RC1A 5JYFA 4WOJA 3H9EO 3DZ6B 1OBFO 1OFGA 3ABIA 3IJPA 5JY6A 3CMCO 4JN6B 2PKQO 1CF2O 4XB1A 5DDIP 4WNIA 3PQVA 1YL6A 3F4LA 4MVJA 1RM5A 4PG5A 3DMTA 2QZ9A 3E9MA 3B1JA 4LRSB 1H6CA 1U1IA 1H9BA 1FF9A 3H0VB 1NQAO 3EPAB 3BIOA 1MC4A 2GZ1A 2IXAA 1K3TA 3RC7A 1GYPA 1BRMA 1H9AA 1NPTO 1PU2A 4MIEA 4XQ9A 1GD1O 3TUTA 4XQCA 3DBVO 1ZH8A 1SZJG 3QVXA 2PH5A 3UUWA 3DZ2B 1PQUA 1A7KA 5C7IO 3DMTC 3WGZA 5GZ3A 2EJWA 4LSMA 4MVJG 1Q2XA 1B7GO 5KVQA 3V2UA 1E5LA 4XRGA 1I7MB 1TLTA 1RM3A 3QVWA 2DPGA 1DRUA 3QV1A 3C8MA 3E5RA 1MB4A 3PFWO 1LA2A 5C7LO 3CPSA 4INAA 1VSVA 1H94A 5BNTA 1LC0A 5M6DA 3K73O 3IP3A 4R4JA 5EIOA 1QMHA 3WBBA 3K9QO 1GPDG 1E77A 2G17A 1YDWA 3C1AA 4MVJI 4PG4A 2PKRA 3TUXA 3O9ZA 1C3VA 3E82A 1JN0A 1EBFA 5JYEA 1YWGO 3Q11A 3EP3B 3MZ0A 2IXBA 3WBFA 1I33A 3WYCA 3BTSA 3RC2A 3HSKA 4DIBA 3EP9B 4XR4A 1NX6A 3BTUA 3EP8B 3RBVA 4MVJP 4PG6A 4CLQA 5GZ6A 3HNPA 3E18A 1YS4A 3L4SO 3OA2A 1DRWA 1GL3A 4DBVO 4MVJH 3EVNA 5CEFA 1VSUA 3PYXA 4GQAA 2GZ2A 4L8VA 1DC5A 4YWJA 4P8RA 1P1FA 3HXLA 3Q1LA 1NQOA 1EBUA 5AQ1A 3L0DA 3ZCXA 2I3GA 5A05A 4GPD1 2X5JO 2FPNA 1DIHA 2VYNA 4K9DA 1DPGA 1Q7GA 1U8FO 3DOCA 4AK1A 2O48X 4MVJD 1TA4A 3DZ7B 2DUUA 4YDRA 3KSDO 1JKIA 3KGDA 3VOSA 4O59O 3K2BA 1GADO 2GD1O 3DB2A 2NQTA 3Q2IA 1DRVA 1NWHA 1HDGO 1DC4A 4R5MA 4MIOA 1F06A 5JYAA 1RM4A 3QVTA 1DBVO 4MINA 1VKOA 2GLXA 3H0WB 3WYBA 1H93A 4O8JA 2Q49A 2GZ3A 3DZ3B 5A03A 3HQ4O 2NVWA 4IQ0A 1E7YA 2EP7A 4IQ8A 3TZ6A 3IWDB 4DPKA 1EVJA 2BH9A 3Q2KA 1QKIA 5GZ1A 1PQPA 2Q4EA 1GCUA 1GR0A 2I5PO 3E6AA 1QMIA 2CVOA 3BTVA 4PLPA 1QXSA 3E1KA 1IHXA 4BOYA 2AXQA 3OQBA 3DZ4B 4KOAA 2BHLA 3INGA 2P2SA 3LC7O 4PG8A 4F3YA 1JKFA 2X0NA 3KUXA 1J5PA 4R3NA 1E7MA 4RL6A 2HKIA 1XYGA 3NT4A 4HADA 3DR3A 4DPLA 4MIYA 2D2IA 2VYVA 2YYYA 4EW6A 3ZJXA 2HJSA 3GDOA 4WNCA 1TVEA 1GYQA 3QW2A 2B4RO 5T73A 4FB5A 1H6DA 2POQX 4GMFA 1P1JA 2EP5A 1I79B 4ZICA 3OA0A 3DO5A 3LC1O 3EPBB 1I7BB 5C7OO 1NBOA 1P1KA 3KSZO 4O89A 2B4TO 1LC3A 4H3VA 3CIFA 3MTJA 2DC1A 4MKXA 4LGVA 3IWBB 2H63A 1S7CA
chains in the Genus database with same CATH topology
3EPBA 1I7BA 3DZ3B 1I7MB 1JL0A 3EP7B 3DZ2A 1TMIA 3DZ6A 3EP9B 1MHMA 3EP8B 1I7CA 1I72A 3DZ5A 1MSVA 3EP4B 3EP3A 1I79B 3H0VA 1JENA 3EPAA 3DZ7A 3EPBB 1I7BB 3H0WA 3DZ4A 3DZ6B 3EP5A 3DZ2B 1I7CB 3EP6A 5TVOA 1MHMB 1I72B 3EP3B 3DZ5B 2IIIA 1I7MA 3DZ3A 3EP7A 1JENB 1TLUA 3EP9A 3H0VB 3EP8A 3EP4A 3EPAB 3DZ7B 1I79A 3EP5B 3H0WB 3DZ4B 5TVOB 1VR7A 3EP6B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DZ3 B;  1I7M B;  3EP7 B;  3EP9 B;  3EP8 B;  3EP4 B;  1I79 B;  3EPB B;  1I7B B;  3DZ6 B;  3DZ2 B;  1I7C B;  1MHM B;  1I72 B;  3EP3 B;  3DZ5 B;  1JEN B;  3H0V B;  3EPA B;  3DZ7 B;  3EP5 B;  3H0W B;  3DZ4 B;  5TVO B;  3EP6 B; 
#chains in the Genus database with same CATH topology
 2GYY A;  3HJA A;  1RYE A;  3Q0E A;  2OZP A;  3NT2 A;  3EC7 A;  3EP4 B;  2G82 A;  3OHS X;  3PZR A;  1H2H A;  4R54 A;  3VAZ A;  3IWC B;  5A04 A;  1YL7 A;  1MHM B;  1DC6 A;  3M2T A;  3DZ5 B;  1NVM B;  3DTY A;  3GNQ A;  1NQ5 A;  3LC2 O;  3NTR A;  4NHE A;  5EIN A;  1YL5 A;  3WGO A;  1GAE O;  4QX6 A;  4TVB A;  3L6O O;  4R41 A;  3EP6 B;  3PYL A;  4L9R A;  3V1Y A;  1P1I A;  4LRT B;  1I32 A;  1T4B A;  2VYN D;  2PKQ P;  1UYJ A;  5A06 A;  3PWS A;  3CEA A;  4O63 O;  3IDS A;  3KV3 O;  1RYD A;  3WGY A;  1I7C B;  1P1H A;  2X5K O;  3GPD G;  1NWC A;  2YV3 A;  4MKZ A;  4MVJ E;  3WB9 A;  5J9G A;  1VM6 A;  1PS8 A;  3MOI A;  3STH A;  1CRW G;  3U3X A;  3RCB A;  1ML3 A;  1OZA A;  1H6A A;  5JW6 A;  1DAP A;  1I72 B;  5EER A;  5KVS A;  1JEN B;  1DSS G;  1H6B A;  4XQE A;  4N54 A;  2DAP A;  1ARZ A;  3PZB A;  4MJL A;  4MVJ F;  4ZHS A;  4R5H A;  4XB2 A;  4DPM A;  3GFG A;  3EP7 B;  3PWK A;  1VKN A;  3RC9 A;  3FHL A;  3B20 A;  1TB4 A;  2HO5 A;  1IHY A;  2Q22 A;  1RM0 A;  3TV1 A;  2CZC A;  3B1K A;  1E5Q A;  3RVD A;  4XQG A;  4R3W A;  3QY9 A;  3NTO A;  2R00 A;  1T4D A;  2O4U X;  3UW3 A;  3FD8 A;  5TVO B;  3NT5 A;  3NTQ A;  3EZY A;  3QVS A;  4HKT A;  3TW3 A;  4PG7 A;  3CIN A;  1ZNQ O;  1VC2 A;  3EUW A;  4II7 A;  3V5N A;  2VYV D;  3JSA A;  4Z0H O;  5A02 A;  4GMG A;  1XEA A;  3LVF O;  1J0X O;  1PR3 A;  1DC3 A;  4R51 A;  5EES A;  3EP5 B;  3DAP A;  5AVO A;  2DBV O;  3PYM A;  2XF8 A;  1P9L A;  1CER A;  3I23 A;  3ZDF A;  2R00 C;  4MVJ M;  3WGQ A;  2I3A A;  3RC1 A;  5JYF A;  4WOJ A;  3H9E O;  3DZ6 B;  1OBF O;  1OFG A;  3ABI A;  3IJP A;  5JY6 A;  3CMC O;  4JN6 B;  2PKQ O;  1CF2 O;  4XB1 A;  5DDI P;  4WNI A;  3PQV A;  1YL6 A;  3F4L A;  4MVJ A;  1RM5 A;  4PG5 A;  3DMT A;  2QZ9 A;  3E9M A;  3B1J A;  4LRS B;  1H6C A;  1U1I A;  1H9B A;  1FF9 A;  3H0V B;  1NQA O;  3EPA B;  3BIO A;  1MC4 A;  2GZ1 A;  2IXA A;  1K3T A;  3RC7 A;  1GYP A;  1BRM A;  1H9A A;  1NPT O;  1PU2 A;  4MIE A;  4XQ9 A;  1GD1 O;  3TUT A;  4XQC A;  3DBV O;  1ZH8 A;  1SZJ G;  3QVX A;  2PH5 A;  3UUW A;  3DZ2 B;  1PQU A;  1A7K A;  5C7I O;  3DMT C;  3WGZ A;  5GZ3 A;  2EJW A;  4LSM A;  4MVJ G;  1Q2X A;  1B7G O;  5KVQ A;  3V2U A;  1E5L A;  4XRG A;  1I7M B;  1TLT A;  1RM3 A;  3QVW A;  2DPG A;  1DRU A;  3QV1 A;  3C8M A;  3E5R A;  1MB4 A;  3PFW O;  1LA2 A;  5C7L O;  3CPS A;  4INA A;  1VSV A;  1H94 A;  5BNT A;  1LC0 A;  5M6D A;  3K73 O;  3IP3 A;  4R4J A;  5EIO A;  1QMH A;  3WBB A;  3K9Q O;  1GPD G;  1E77 A;  2G17 A;  1YDW A;  3C1A A;  4MVJ I;  4PG4 A;  2PKR A;  3TUX A;  3O9Z A;  1C3V A;  3E82 A;  1JN0 A;  1EBF A;  5JYE A;  1YWG O;  3Q11 A;  3EP3 B;  3MZ0 A;  2IXB A;  3WBF A;  1I33 A;  3WYC A;  3BTS A;  3RC2 A;  3HSK A;  4DIB A;  3EP9 B;  4XR4 A;  1NX6 A;  3BTU A;  3EP8 B;  3RBV A;  4MVJ P;  4PG6 A;  4CLQ A;  5GZ6 A;  3HNP A;  3E18 A;  1YS4 A;  3L4S O;  3OA2 A;  1DRW A;  1GL3 A;  4DBV O;  4MVJ H;  3EVN A;  5CEF A;  1VSU A;  3PYX A;  4GQA A;  2GZ2 A;  4L8V A;  1DC5 A;  4YWJ A;  4P8R A;  1P1F A;  3HXL A;  3Q1L A;  1NQO A;  1EBU A;  5AQ1 A;  3L0D A;  3ZCX A;  2I3G A;  5A05 A;  4GPD 1;  2X5J O;  2FPN A;  1DIH A;  2VYN A;  4K9D A;  1DPG A;  1Q7G A;  1U8F O;  3DOC A;  4AK1 A;  2O48 X;  4MVJ D;  1TA4 A;  3DZ7 B;  2DUU A;  4YDR A;  3KSD O;  1JKI A;  3KGD A;  3VOS A;  4O59 O;  3K2B A;  1GAD O;  2GD1 O;  3DB2 A;  2NQT A;  3Q2I A;  1DRV A;  1NWH A;  1HDG O;  1DC4 A;  4R5M A;  4MIO A;  1F06 A;  5JYA A;  1RM4 A;  3QVT A;  1DBV O;  4MIN A;  1VKO A;  2GLX A;  3H0W B;  3WYB A;  1H93 A;  4O8J A;  2Q49 A;  2GZ3 A;  3DZ3 B;  5A03 A;  3HQ4 O;  2NVW A;  4IQ0 A;  1E7Y A;  2EP7 A;  4IQ8 A;  3TZ6 A;  3IWD B;  4DPK A;  1EVJ A;  2BH9 A;  3Q2K A;  1QKI A;  5GZ1 A;  1PQP A;  2Q4E A;  1GCU A;  1GR0 A;  2I5P O;  3E6A A;  1QMI A;  2CVO A;  3BTV A;  4PLP A;  1QXS A;  3E1K A;  1IHX A;  4BOY A;  2AXQ A;  3OQB A;  3DZ4 B;  4KOA A;  2BHL A;  3ING A;  2P2S A;  3LC7 O;  4PG8 A;  4F3Y A;  1JKF A;  2X0N A;  3KUX A;  1J5P A;  4R3N A;  1E7M A;  4RL6 A;  2HKI A;  1XYG A;  3NT4 A;  4HAD A;  3DR3 A;  4DPL A;  4MIY A;  2D2I A;  2VYV A;  2YYY A;  4EW6 A;  3ZJX A;  2HJS A;  3GDO A;  4WNC A;  1TVE A;  1GYQ A;  3QW2 A;  2B4R O;  5T73 A;  4FB5 A;  1H6D A;  2POQ X;  4GMF A;  1P1J A;  2EP5 A;  1I79 B;  4ZIC A;  3OA0 A;  3DO5 A;  3LC1 O;  3EPB B;  1I7B B;  5C7O O;  1NBO A;  1P1K A;  3KSZ O;  4O89 A;  2B4T O;  1LC3 A;  4H3V A;  3CIF A;  3MTJ A;  2DC1 A;  4MKX A;  4LGV A;  3IWB B;  2H63 A;  1S7C A; 
#chains in the Genus database with same CATH homology
 3EPB A;  1I7B A;  3DZ3 B;  1I7M B;  1JL0 A;  3EP7 B;  3DZ2 A;  1TMI A;  3DZ6 A;  3EP9 B;  1MHM A;  3EP8 B;  1I7C A;  1I72 A;  3DZ5 A;  1MSV A;  3EP4 B;  3EP3 A;  1I79 B;  3H0V A;  1JEN A;  3EPA A;  3DZ7 A;  3EPB B;  1I7B B;  3H0W A;  3DZ4 A;  3DZ6 B;  3EP5 A;  3DZ2 B;  1I7C B;  3EP6 A;  5TVO A;  1MHM B;  1I72 B;  3EP3 B;  3DZ5 B;  2III A;  1I7M A;  3DZ3 A;  3EP7 A;  1JEN B;  1TLU A;  3EP9 A;  3H0V B;  3EP8 A;  3EP4 A;  3EPA B;  3DZ7 B;  1I79 A;  3EP5 B;  3H0W B;  3DZ4 B;  5TVO B;  1VR7 A;  3EP6 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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