1I79A

Human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and covalently bound 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
Total Genus 65
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
260
structure length
251
Chain Sequence
SMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAGYCMGRMNSDCWYLYTLDFPESQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRPQKIEGFKRLDCQSAMFNDYNFVFTSFAKK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN
total genus 65
structure length 251
sequence length 260
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2001-03-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.90.10 Alpha Beta 4-Layer Sandwich S-adenosylmethionine decarboxylase S-adenosylmethionine decarboxylase 1i79A00
1VR7A 3EPBA 3H0WA 3H0VA 3DZ6A 1JL0A 2IIIA 3DZ7A 3DZ2A 1I72A 3EP9A 1I7CA 1I7BA 1I7MA 3EPAA 1TMIA 3DZ5A 3EP6A 1JENA 1I79A 3DZ4A 3EP5A 3EP4A 3EP7A 3EP8A 1MSVA 3DZ3A 3EP3A 1MHMA 1TLUA 5TVOA
chains in the Genus database with same CATH superfamily
1VR7A 3EPBA 3H0WA 3H0VA 3DZ6A 1JL0A 2IIIA 3DZ7A 3DZ2A 1I72A 3EP9A 1I7CA 1I7BA 1I7MA 3EPAA 1TMIA 3DZ5A 3EP6A 1JENA 1I79A 3DZ4A 3EP5A 3EP4A 3EP7A 3EP8A 1MSVA 3DZ3A 3EP3A 1MHMA 1TLUA 5TVOA
chains in the Genus database with same CATH topology
1VR7A 3EPBA 3H0WA 3H0VA 3DZ3B 3DZ6A 1JL0A 3EP3B 2IIIA 3DZ7A 3DZ2A 1I72A 3EP9A 1MHMB 1I7CA 1I7BA 1I7MA 3EPAA 5TVOB 3EPBB 3H0WB 1TMIA 3DZ6B 3H0VB 3DZ5A 3EP6A 1JENA 1I79A 1I72B 3DZ4A 3DZ7B 3EP5A 3DZ2B 3EP4A 3EP9B 3EP7A 3EP8A 1I7CB 1I7BB 1I7MB 1MSVA 3EPAB 3DZ3A 3DZ5B 3EP6B 1JENB 3EP3A 1I79B 1MHMA 3DZ4B 3EP5B 3EP4B 3EP7B 1TLUA 3EP8B 5TVOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1VR7 A;  3EPB A;  3H0W A;  3H0V A;  3DZ6 A;  1JL0 A;  2III A;  3DZ7 A;  3DZ2 A;  1I72 A;  3EP9 A;  1I7C A;  1I7B A;  1I7M A;  3EPA A;  1TMI A;  3DZ5 A;  3EP6 A;  1JEN A;  1I79 A;  3DZ4 A;  3EP5 A;  3EP4 A;  3EP7 A;  3EP8 A;  1MSV A;  3DZ3 A;  3EP3 A;  1MHM A;  1TLU A;  5TVO A; 
#chains in the Genus database with same CATH topology
 1VR7 A;  3EPB A;  3H0W A;  3H0V A;  3DZ6 A;  1JL0 A;  2III A;  3DZ7 A;  3DZ2 A;  1I72 A;  3EP9 A;  1I7C A;  1I7B A;  1I7M A;  3EPA A;  1TMI A;  3DZ5 A;  3EP6 A;  1JEN A;  1I79 A;  3DZ4 A;  3EP5 A;  3EP4 A;  3EP7 A;  3EP8 A;  1MSV A;  3DZ3 A;  3EP3 A;  1MHM A;  1TLU A;  5TVO A; 
#chains in the Genus database with same CATH homology
 1VR7 A;  3EPB A;  3H0W A;  3H0V A;  3DZ3 B;  3DZ6 A;  1JL0 A;  3EP3 B;  2III A;  3DZ7 A;  3DZ2 A;  1I72 A;  3EP9 A;  1MHM B;  1I7C A;  1I7B A;  1I7M A;  3EPA A;  5TVO B;  3EPB B;  3H0W B;  1TMI A;  3DZ6 B;  3H0V B;  3DZ5 A;  3EP6 A;  1JEN A;  1I79 A;  1I72 B;  3DZ4 A;  3DZ7 B;  3EP5 A;  3DZ2 B;  3EP4 A;  3EP9 B;  3EP7 A;  3EP8 A;  1I7C B;  1I7B B;  1I7M B;  1MSV A;  3EPA B;  3DZ3 A;  3DZ5 B;  3EP6 B;  1JEN B;  3EP3 A;  1I79 B;  1MHM A;  3DZ4 B;  3EP5 B;  3EP4 B;  3EP7 B;  1TLU A;  3EP8 B;  5TVO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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