1IT6A

Crystal structure of the complex between calyculin a and the catalytic subunit of protein phosphatase 1
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
293
structure length
293
Chain Sequence
LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the complex between calyculin A and the catalytic subunit of protein phosphatase 1.
pubmed doi rcsb
molecule keywords SERINE/THREONINE PROTEIN PHOSPHATASE 1 GAMMA (PP1-GAMMA) CAT
molecule tags Hydrolase
source organism Homo sapiens
total genus 109
structure length 293
sequence length 293
chains with identical sequence B
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2002-01-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF16891 STPPase_N Serine-threonine protein phosphatase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 1it6A00
4H2GA 5EQVA 3DSDA 3FGAC 4FCXA 4LACC 1G5BA 4ORCA 3V4YA 3KBPA 2YVTA 3DSCA 2AHDA 3PSOA 1XZWA 1FJMA 4DT2A 1KBPA 2IE4C 4NZVA 3AUZA 3JYFA 3H64A 2HY1A 1T70A 3IB8A 4G9JA 3H69A 2A22A 3TGHA 3K7WC 3E7AA 1HPUA 1OIEA 3H62B 1HO5A 3QFNA 1SU1A 2NXFA 2WDCA 1TCOA 3H67A 3QFKA 4JA7A 4KKZA 1HP1A 2WDFA 3ICFA 5JJTA 1S8EA 5JPEA 4O24A 2Z06A 1M63A 3QG5C 1V73A 4TUGA 3IVDA 5B8IA 3EGHA 3H68A 3QFOA 4MP0A 1UTEA 4V0XA 2P6BA 3RL4A 4Q7FA 4UT3B 2Q8UA 2IE3C 2KKNA 3H60A 3P71C 4IL1A 2GJUA 2JOGA 4F0ZA 1XM7A 4H1SA 1MF8A 3H63A 4YKEA 5F3WA 1OIDA 1JK7A 4UT3A 2BQ8X 2R17A 4UT2A 5DNYA 1QFCA 2USHA 1S95A 3PSNA 4MOYA 4B2OA 2Z72A 3T1IA 4JA9A 5INBA 2NYLC 3H61A 1T71A 1W24A 3K7VC 4H2BA 3IVEA 2HYPA 5GTUA 4I5LC 1S3MA 4OR9A 2NYMC 4J6OA 4FBQA 4H2FA 4ORAA 4V0VA 4ZVZA 2HYOA 3CK2A 3RL5A 3HVQA 3QFMA 4HD0A 5JPFA 4O4KA 2QFRA 2NPPC 3THOB 2Z1AA 1S70A 3EGGA 4LU9A 3DW8C 4XPNA 2WDEA 2O8AA 3LL8A 4KBPA 1U32A 3IB7A 4H2IA 1UF3A 3THNA 1USHA 1IT6A 2IAEC 1OI8A 4FBKA 4ORBA 2DFJA 3C9FA 3N5UA 1Z2XA 5J28A 4TUIA 4H1YP 2XMOA 4V0WA 2QFPA 1AUIA 4WWLA 3C5WC 4DHLA 1S3LA 1Z2WA 4O43A 5HPEA 4DSYA 5IOHA 3GVEA 3RQZA 4MOVA 2CV9A 1WAO1 2QJCA 1S3NA 3E7BA 4FBWA 1QHWA 2BCDA 3ZU0A 2WDDA 4LTYA 3AV0A 1II7A 4I5NC 4M0VA 4UWQA 3H66A 2O8GA 4ZX2A 1NNWA 5C1VA 2BDXA 3ZTVA 1WARA 4O5GA 4IYPC 3RL3A 2ZBMA
chains in the Genus database with same CATH superfamily
4H2GA 5EQVA 3DSDA 3FGAC 4FCXA 4LACC 1G5BA 4ORCA 3V4YA 3KBPA 2YVTA 3DSCA 2AHDA 3PSOA 1XZWA 1FJMA 4DT2A 1KBPA 2IE4C 4NZVA 3AUZA 3D03A 3H64A 2HY1A 3JYFA 1T70A 3IB8A 4G9JA 3H69A 2A22A 3TGHA 3K7WC 3E7AA 1HPUA 1OIEA 3H62B 1HO5A 2YEQA 3QFNA 1SU1A 2WDCA 2NXFA 1TCOA 3H67A 3QFKA 4JA7A 4KKZA 1HP1A 2WDFA 3ICFA 5JJTA 1S8EA 5JPEA 4O24A 1M63A 2Z06A 3QG5C 1V73A 4TUGA 3IVDA 5B8IA 3EGHA 3H68A 3QFOA 4MP0A 1UTEA 4V0XA 2P6BA 3RL4A 4Q7FA 4UT3B 2Q8UA 2IE3C 2KKNA 3H60A 3P71C 4IL1A 2GJUA 2JOGA 4F0ZA 1XM7A 3E0JA 1MF8A 3H63A 4H1SA 4YKEA 5F3WA 1OIDA 1JK7A 4UT3A 2BQ8X 2R17A 4UT2A 5DNYA 1QFCA 2USHA 2DXNA 1S95A 3PSNA 4MOYA 4B2OA 2Z72A 3T1IA 4JA9A 5INBA 2ZOAA 2NYLC 3H61A 1T71A 1W24A 3K7VC 4H2BA 3IVEA 2HYPA 5GTUA 4I5LC 1S3MA 4OR9A 2NYMC 4J6OA 4FBQA 4H2FA 4ORAA 4V0VA 4ZVZA 2HYOA 3CK2A 3RL5A 3HVQA 3QFMA 4HD0A 3FLOA 5JPFA 4O4KA 2QFRA 2NPPC 3THOB 2Z1AA 1S70A 3EGGA 4LU9A 3DW8C 4XPNA 2WDEA 2O8AA 3LL8A 4KBPA 1U32A 2ZO9B 3IB7A 4H2IA 1UF3A 3THNA 1USHA 1IT6A 2IAEC 1OI8A 4FBKA 4ORBA 2DFJA 3C9FA 3N5UA 1Z2XA 5J28A 4TUIA 4H1YP 2XMOA 4V0WA 2QFPA 1AUIA 4WWLA 3C5WC 4DHLA 1S3LA 1Z2WA 4O43A 5HPEA 4DSYA 5IOHA 3GVEA 3RQZA 4MOVA 2CV9A 1WAO1 2QJCA 1S3NA 3E7BA 4FBWA 1QHWA 2BCDA 3ZU0A 2WDDA 4LTYA 3AV0A 1II7A 4I5NC 4M0VA 4UWQA 3H66A 2O8GA 4ZX2A 2DXLA 1NNWA 5C1VA 2BDXA 3ZTVA 1WARA 4O5GA 4IYPC 3RL3A 2ZBMA
chains in the Genus database with same CATH topology
4H2GA 5EQVA 3DSDA 3FGAC 4FCXA 4LACC 1G5BA 4ORCA 3V4YA 3KBPA 2YVTA 3DSCA 2AHDA 3PSOA 1XZWA 1FJMA 4DT2A 1KBPA 2IE4C 4NZVA 3AUZA 3D03A 3H64A 2HY1A 3JYFA 1T70A 3IB8A 4G9JA 3H69A 2A22A 3TGHA 3K7WC 3E7AA 1HPUA 1OIEA 3H62B 1HO5A 2YEQA 3QFNA 1SU1A 2WDCA 2NXFA 1TCOA 3H67A 3QFKA 4JA7A 4KKZA 1HP1A 2WDFA 3ICFA 5JJTA 1S8EA 5JPEA 4O24A 1M63A 2Z06A 3QG5C 1V73A 4TUGA 3IVDA 5B8IA 3EGHA 3H68A 3QFOA 4MP0A 1UTEA 4V0XA 2P6BA 3RL4A 4Q7FA 4UT3B 2Q8UA 2IE3C 2KKNA 3H60A 3P71C 4IL1A 2GJUA 2JOGA 4F0ZA 1XM7A 3E0JA 1MF8A 3H63A 4H1SA 4YKEA 5F3WA 1OIDA 1JK7A 4UT3A 2BQ8X 2R17A 4UT2A 5DNYA 1QFCA 2USHA 2DXNA 1S95A 3PSNA 4MOYA 4B2OA 2Z72A 3T1IA 4JA9A 5INBA 2ZOAA 2NYLC 3H61A 1T71A 1W24A 3K7VC 4H2BA 3IVEA 2HYPA 5GTUA 4I5LC 1S3MA 4OR9A 2NYMC 4J6OA 4FBQA 4H2FA 4ORAA 4V0VA 4ZVZA 2HYOA 3CK2A 3RL5A 3HVQA 3QFMA 4HD0A 3FLOA 5JPFA 4O4KA 2QFRA 2NPPC 3THOB 2Z1AA 1S70A 3EGGA 4LU9A 3DW8C 4XPNA 2WDEA 2O8AA 3LL8A 4KBPA 1U32A 2ZO9B 3IB7A 4H2IA 1UF3A 3THNA 1USHA 1IT6A 2IAEC 1OI8A 4FBKA 4ORBA 2DFJA 3C9FA 3N5UA 1Z2XA 5J28A 4TUIA 4H1YP 2XMOA 4V0WA 2QFPA 1AUIA 4WWLA 3C5WC 4DHLA 1S3LA 1Z2WA 4O43A 5HPEA 4DSYA 5IOHA 3GVEA 3RQZA 4MOVA 2CV9A 1WAO1 2QJCA 1S3NA 3E7BA 4FBWA 1QHWA 2BCDA 3ZU0A 2WDDA 4LTYA 3AV0A 1II7A 4I5NC 4M0VA 4UWQA 3H66A 2O8GA 4ZX2A 2DXLA 1NNWA 5C1VA 2BDXA 3ZTVA 1WARA 4O5GA 4IYPC 3RL3A 2ZBMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4H2G A;  5EQV A;  3DSD A;  3FGA C;  4FCX A;  4LAC C;  1G5B A;  4ORC A;  3V4Y A;  3KBP A;  2YVT A;  3DSC A;  2AHD A;  3PSO A;  1XZW A;  1FJM A;  4DT2 A;  1KBP A;  2IE4 C;  4NZV A;  3AUZ A;  3JYF A;  3H64 A;  2HY1 A;  1T70 A;  3IB8 A;  4G9J A;  3H69 A;  2A22 A;  3TGH A;  3K7W C;  3E7A A;  1HPU A;  1OIE A;  3H62 B;  1HO5 A;  3QFN A;  1SU1 A;  2NXF A;  2WDC A;  1TCO A;  3H67 A;  3QFK A;  4JA7 A;  4KKZ A;  1HP1 A;  2WDF A;  3ICF A;  5JJT A;  1S8E A;  5JPE A;  4O24 A;  2Z06 A;  1M63 A;  3QG5 C;  1V73 A;  4TUG A;  3IVD A;  5B8I A;  3EGH A;  3H68 A;  3QFO A;  4MP0 A;  1UTE A;  4V0X A;  2P6B A;  3RL4 A;  4Q7F A;  4UT3 B;  2Q8U A;  2IE3 C;  2KKN A;  3H60 A;  3P71 C;  4IL1 A;  2GJU A;  2JOG A;  4F0Z A;  1XM7 A;  4H1S A;  1MF8 A;  3H63 A;  4YKE A;  5F3W A;  1OID A;  1JK7 A;  4UT3 A;  2BQ8 X;  2R17 A;  4UT2 A;  5DNY A;  1QFC A;  2USH A;  1S95 A;  3PSN A;  4MOY A;  4B2O A;  2Z72 A;  3T1I A;  4JA9 A;  5INB A;  2NYL C;  3H61 A;  1T71 A;  1W24 A;  3K7V C;  4H2B A;  3IVE A;  2HYP A;  5GTU A;  4I5L C;  1S3M A;  4OR9 A;  2NYM C;  4J6O A;  4FBQ A;  4H2F A;  4ORA A;  4V0V A;  4ZVZ A;  2HYO A;  3CK2 A;  3RL5 A;  3HVQ A;  3QFM A;  4HD0 A;  5JPF A;  4O4K A;  2QFR A;  2NPP C;  3THO B;  2Z1A A;  1S70 A;  3EGG A;  4LU9 A;  3DW8 C;  4XPN A;  2WDE A;  2O8A A;  3LL8 A;  4KBP A;  1U32 A;  3IB7 A;  4H2I A;  1UF3 A;  3THN A;  1USH A;  1IT6 A;  2IAE C;  1OI8 A;  4FBK A;  4ORB A;  2DFJ A;  3C9F A;  3N5U A;  1Z2X A;  5J28 A;  4TUI A;  4H1Y P;  2XMO A;  4V0W A;  2QFP A;  1AUI A;  4WWL A;  3C5W C;  4DHL A;  1S3L A;  1Z2W A;  4O43 A;  5HPE A;  4DSY A;  5IOH A;  3GVE A;  3RQZ A;  4MOV A;  2CV9 A;  1WAO 1;  2QJC A;  1S3N A;  3E7B A;  4FBW A;  1QHW A;  2BCD A;  3ZU0 A;  2WDD A;  4LTY A;  3AV0 A;  1II7 A;  4I5N C;  4M0V A;  4UWQ A;  3H66 A;  2O8G A;  4ZX2 A;  1NNW A;  5C1V A;  2BDX A;  3ZTV A;  1WAR A;  4O5G A;  4IYP C;  3RL3 A;  2ZBM A; 
#chains in the Genus database with same CATH topology
 4H2G A;  5EQV A;  3DSD A;  3FGA C;  4FCX A;  4LAC C;  1G5B A;  4ORC A;  3V4Y A;  3KBP A;  2YVT A;  3DSC A;  2AHD A;  3PSO A;  1XZW A;  1FJM A;  4DT2 A;  1KBP A;  2IE4 C;  4NZV A;  3AUZ A;  3D03 A;  3H64 A;  2HY1 A;  3JYF A;  1T70 A;  3IB8 A;  4G9J A;  3H69 A;  2A22 A;  3TGH A;  3K7W C;  3E7A A;  1HPU A;  1OIE A;  3H62 B;  1HO5 A;  2YEQ A;  3QFN A;  1SU1 A;  2WDC A;  2NXF A;  1TCO A;  3H67 A;  3QFK A;  4JA7 A;  4KKZ A;  1HP1 A;  2WDF A;  3ICF A;  5JJT A;  1S8E A;  5JPE A;  4O24 A;  1M63 A;  2Z06 A;  3QG5 C;  1V73 A;  4TUG A;  3IVD A;  5B8I A;  3EGH A;  3H68 A;  3QFO A;  4MP0 A;  1UTE A;  4V0X A;  2P6B A;  3RL4 A;  4Q7F A;  4UT3 B;  2Q8U A;  2IE3 C;  2KKN A;  3H60 A;  3P71 C;  4IL1 A;  2GJU A;  2JOG A;  4F0Z A;  1XM7 A;  3E0J A;  1MF8 A;  3H63 A;  4H1S A;  4YKE A;  5F3W A;  1OID A;  1JK7 A;  4UT3 A;  2BQ8 X;  2R17 A;  4UT2 A;  5DNY A;  1QFC A;  2USH A;  2DXN A;  1S95 A;  3PSN A;  4MOY A;  4B2O A;  2Z72 A;  3T1I A;  4JA9 A;  5INB A;  2ZOA A;  2NYL C;  3H61 A;  1T71 A;  1W24 A;  3K7V C;  4H2B A;  3IVE A;  2HYP A;  5GTU A;  4I5L C;  1S3M A;  4OR9 A;  2NYM C;  4J6O A;  4FBQ A;  4H2F A;  4ORA A;  4V0V A;  4ZVZ A;  2HYO A;  3CK2 A;  3RL5 A;  3HVQ A;  3QFM A;  4HD0 A;  3FLO A;  5JPF A;  4O4K A;  2QFR A;  2NPP C;  3THO B;  2Z1A A;  1S70 A;  3EGG A;  4LU9 A;  3DW8 C;  4XPN A;  2WDE A;  2O8A A;  3LL8 A;  4KBP A;  1U32 A;  2ZO9 B;  3IB7 A;  4H2I A;  1UF3 A;  3THN A;  1USH A;  1IT6 A;  2IAE C;  1OI8 A;  4FBK A;  4ORB A;  2DFJ A;  3C9F A;  3N5U A;  1Z2X A;  5J28 A;  4TUI A;  4H1Y P;  2XMO A;  4V0W A;  2QFP A;  1AUI A;  4WWL A;  3C5W C;  4DHL A;  1S3L A;  1Z2W A;  4O43 A;  5HPE A;  4DSY A;  5IOH A;  3GVE A;  3RQZ A;  4MOV A;  2CV9 A;  1WAO 1;  2QJC A;  1S3N A;  3E7B A;  4FBW A;  1QHW A;  2BCD A;  3ZU0 A;  2WDD A;  4LTY A;  3AV0 A;  1II7 A;  4I5N C;  4M0V A;  4UWQ A;  3H66 A;  2O8G A;  4ZX2 A;  2DXL A;  1NNW A;  5C1V A;  2BDX A;  3ZTV A;  1WAR A;  4O5G A;  4IYP C;  3RL3 A;  2ZBM A; 
#chains in the Genus database with same CATH homology
 4H2G A;  5EQV A;  3DSD A;  3FGA C;  4FCX A;  4LAC C;  1G5B A;  4ORC A;  3V4Y A;  3KBP A;  2YVT A;  3DSC A;  2AHD A;  3PSO A;  1XZW A;  1FJM A;  4DT2 A;  1KBP A;  2IE4 C;  4NZV A;  3AUZ A;  3D03 A;  3H64 A;  2HY1 A;  3JYF A;  1T70 A;  3IB8 A;  4G9J A;  3H69 A;  2A22 A;  3TGH A;  3K7W C;  3E7A A;  1HPU A;  1OIE A;  3H62 B;  1HO5 A;  2YEQ A;  3QFN A;  1SU1 A;  2WDC A;  2NXF A;  1TCO A;  3H67 A;  3QFK A;  4JA7 A;  4KKZ A;  1HP1 A;  2WDF A;  3ICF A;  5JJT A;  1S8E A;  5JPE A;  4O24 A;  1M63 A;  2Z06 A;  3QG5 C;  1V73 A;  4TUG A;  3IVD A;  5B8I A;  3EGH A;  3H68 A;  3QFO A;  4MP0 A;  1UTE A;  4V0X A;  2P6B A;  3RL4 A;  4Q7F A;  4UT3 B;  2Q8U A;  2IE3 C;  2KKN A;  3H60 A;  3P71 C;  4IL1 A;  2GJU A;  2JOG A;  4F0Z A;  1XM7 A;  3E0J A;  1MF8 A;  3H63 A;  4H1S A;  4YKE A;  5F3W A;  1OID A;  1JK7 A;  4UT3 A;  2BQ8 X;  2R17 A;  4UT2 A;  5DNY A;  1QFC A;  2USH A;  2DXN A;  1S95 A;  3PSN A;  4MOY A;  4B2O A;  2Z72 A;  3T1I A;  4JA9 A;  5INB A;  2ZOA A;  2NYL C;  3H61 A;  1T71 A;  1W24 A;  3K7V C;  4H2B A;  3IVE A;  2HYP A;  5GTU A;  4I5L C;  1S3M A;  4OR9 A;  2NYM C;  4J6O A;  4FBQ A;  4H2F A;  4ORA A;  4V0V A;  4ZVZ A;  2HYO A;  3CK2 A;  3RL5 A;  3HVQ A;  3QFM A;  4HD0 A;  3FLO A;  5JPF A;  4O4K A;  2QFR A;  2NPP C;  3THO B;  2Z1A A;  1S70 A;  3EGG A;  4LU9 A;  3DW8 C;  4XPN A;  2WDE A;  2O8A A;  3LL8 A;  4KBP A;  1U32 A;  2ZO9 B;  3IB7 A;  4H2I A;  1UF3 A;  3THN A;  1USH A;  1IT6 A;  2IAE C;  1OI8 A;  4FBK A;  4ORB A;  2DFJ A;  3C9F A;  3N5U A;  1Z2X A;  5J28 A;  4TUI A;  4H1Y P;  2XMO A;  4V0W A;  2QFP A;  1AUI A;  4WWL A;  3C5W C;  4DHL A;  1S3L A;  1Z2W A;  4O43 A;  5HPE A;  4DSY A;  5IOH A;  3GVE A;  3RQZ A;  4MOV A;  2CV9 A;  1WAO 1;  2QJC A;  1S3N A;  3E7B A;  4FBW A;  1QHW A;  2BCD A;  3ZU0 A;  2WDD A;  4LTY A;  3AV0 A;  1II7 A;  4I5N C;  4M0V A;  4UWQ A;  3H66 A;  2O8G A;  4ZX2 A;  2DXL A;  1NNW A;  5C1V A;  2BDX A;  3ZTV A;  1WAR A;  4O5G A;  4IYP C;  3RL3 A;  2ZBM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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