1JL0A

Structure of a human s-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the h243a mutant
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
325
structure length
310
Chain Sequence
HFFEGTEKLLEVWFSRQQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAGYCMGRMNSDCWYLYTLDFPVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIAITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
molecule keywords S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME
publication title Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant.
pubmed doi rcsb
source organism Homo sapiens
total genus 91
structure length 310
sequence length 325
chains with identical sequence B
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2001-07-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01536 SAM_decarbox Adenosylmethionine decarboxylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.90.10 Alpha Beta 4-Layer Sandwich S-adenosylmethionine decarboxylase S-adenosylmethionine decarboxylase 1jl0A00
1I7BA 3DZ7A 3EP8A 1MSVA 1JENA 3H0WA 1I79A 2IIIA 3H0VA 1I7MA 5TVOA 1VR7A 3DZ2A 1MHMA 3DZ5A 1I7CA 1TMIA 1TLUA 3EP4A 3EP9A 3DZ4A 3DZ3A 3EP7A 3EPBA 1JL0A 3EP6A 1I72A 3DZ6A 3EP5A 3EP3A 3EPAA
chains in the Genus database with same CATH superfamily
1I7BA 3DZ7A 3EP8A 1MSVA 1JENA 3H0WA 1I79A 2IIIA 3H0VA 1I7MA 5TVOA 1VR7A 3DZ2A 1MHMA 3DZ5A 1I7CA 1TMIA 1TLUA 3EP4A 3EP9A 3DZ4A 3DZ3A 3EP7A 3EPBA 1JL0A 3EP6A 1I72A 3DZ6A 3EP5A 3EP3A 3EPAA
chains in the Genus database with same CATH topology
1I7BA 3DZ5B 1I7CB 3DZ7A 3EP8A 1MSVA 3EP4B 3EP9B 1JENA 3DZ4B 3H0WA 1I79A 3DZ3B 3EP6B 2IIIA 3EP7B 3EPBB 3H0VA 1I72B 3DZ6B 1I7MA 3EP5B 3EP3B 5TVOA 1VR7A 3DZ2A 3EPAB 1I7BB 3DZ7B 3EP8B 1MHMA 3DZ5A 1I7CA 1TMIA 1TLUA 1JENB 3EP4A 3H0WB 1I79B 3EP9A 3DZ4A 3H0VB 3DZ3A 3EP7A 3EPBA 1JL0A 3EP6A 1I7MB 1I72A 3DZ6A 5TVOB 3DZ2B 3EP5A 3EP3A 1MHMB 3EPAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I7B A;  3DZ7 A;  3EP8 A;  1MSV A;  1JEN A;  3H0W A;  1I79 A;  2III A;  3H0V A;  1I7M A;  5TVO A;  1VR7 A;  3DZ2 A;  1MHM A;  3DZ5 A;  1I7C A;  1TMI A;  1TLU A;  3EP4 A;  3EP9 A;  3DZ4 A;  3DZ3 A;  3EP7 A;  3EPB A;  1JL0 A;  3EP6 A;  1I72 A;  3DZ6 A;  3EP5 A;  3EP3 A;  3EPA A; 
#chains in the Genus database with same CATH topology
 1I7B A;  3DZ7 A;  3EP8 A;  1MSV A;  1JEN A;  3H0W A;  1I79 A;  2III A;  3H0V A;  1I7M A;  5TVO A;  1VR7 A;  3DZ2 A;  1MHM A;  3DZ5 A;  1I7C A;  1TMI A;  1TLU A;  3EP4 A;  3EP9 A;  3DZ4 A;  3DZ3 A;  3EP7 A;  3EPB A;  1JL0 A;  3EP6 A;  1I72 A;  3DZ6 A;  3EP5 A;  3EP3 A;  3EPA A; 
#chains in the Genus database with same CATH homology
 1I7B A;  3DZ5 B;  1I7C B;  3DZ7 A;  3EP8 A;  1MSV A;  3EP4 B;  3EP9 B;  1JEN A;  3DZ4 B;  3H0W A;  1I79 A;  3DZ3 B;  3EP6 B;  2III A;  3EP7 B;  3EPB B;  3H0V A;  1I72 B;  3DZ6 B;  1I7M A;  3EP5 B;  3EP3 B;  5TVO A;  1VR7 A;  3DZ2 A;  3EPA B;  1I7B B;  3DZ7 B;  3EP8 B;  1MHM A;  3DZ5 A;  1I7C A;  1TMI A;  1TLU A;  1JEN B;  3EP4 A;  3H0W B;  1I79 B;  3EP9 A;  3DZ4 A;  3H0V B;  3DZ3 A;  3EP7 A;  3EPB A;  1JL0 A;  3EP6 A;  1I7M B;  1I72 A;  3DZ6 A;  5TVO B;  3DZ2 B;  3EP5 A;  3EP3 A;  1MHM B;  3EPA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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