1K8TA

Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef)
Total Genus 147
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
147
sequence length
509
structure length
498
Chain Sequence
DRIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSNVGVYKDSGDKDEFAKKESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKSNIEFKLLYKQLNFTENETDNFEVFQKIIDE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords CALMODULIN-SENSITIVE ADENYLATE CYCLASE
publication title Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin
pubmed doi rcsb
source organism Bacillus anthracis
molecule tags Toxin,lyase
total genus 147
structure length 498
sequence length 509
ec nomenclature ec 4.6.1.1: Adenylate cyclase.
pdb deposition date 2001-10-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03497 Anthrax_toxA Anthrax toxin LF subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.140.60 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A; domain 3 1k8tA03
3.90.1760.10 Alpha Beta Alpha-Beta Complex Adenylylcyclase toxin fold Anthrax toxin, edema factor, central domain 1k8tA02
1PK0A 1LVCA 1XFWA 1K8TA 1XFYA 1XFXA 1XFZA 1YRUA 2COLA 1K93A 1K90A 1S26A 1SK6A 1XFUA 1XFVA 1YRTA 1Y0VA 1ZOTA
chains in the Genus database with same CATH superfamily
2EBAA 2OR0A 2Q8HA 2R0MA 2RFQA 3F29A 2F6LA 3MPJA 2Q8IA 1YRUA 5BRMA 2R05A 1OAHA 1XFVA 1U8VA 1QDBA 2YYIA 4H7QA 4ZXVA 1RP3A 2YYMA 2BU5A 2XQRB 2YYJA 2HJNA 2ZO5A 2UXWA 3FCJA 4O5MA 3BNFA 2RDZA 3S7WA 3SF6A 3D1IA 4KSAA 2PNRA 4Q0TA 3Q23A 1T9GA 1YRTA 2BU6A 3GQTA 2YYKA 3X29A 3CRLA 3CE2A 2JIFA 3LGQA 3M9VA 3RKHA 1JM6A 5K3HA 2JBSA 4L38A 1Y8NA 1Y8PA 3CRKA 4AI6A 3C3LA 1Y8OA 3P4TA 4FF3A 1K90A 4MPCA 4FF4A 4H85A 2VIGA 1BUCA 2ZKJA 4X28A 4X28C 5B6BA 5M4PA 2COLA 2IX6A 3EOMA 1FS8A 2OEVA 4KSFA 3FO3A 4H81A 4V26A 4WJYA 3MDDA 3TZ0A 1EGDA 1GJVA 2D29A 1RX0A 2EBFX 2R0NA 2R03A 3D2RA 2YYGA 2ZDYA 2Q8GA 4ZYJA 1R3BA 1IVHA 1W07A 2JBRA 4G5EA 4KCFA 3TZ4A 5M4MA 4HKRA 5GJWE 4E01A 3EONA 3C46A 1XFXA 4L3YA 1JQIA 2YYLA 4Q17A 2PG0A 3Q24A 3VKHA 3AFFA 5GJVE 2YGWA 4OO2A 4NXLA 1R2JA 1WS9A 3L1TA 3D9DA 4KTOA 4LQQB 4Q1OA 4V25A 2CX9A 1X90A 3B96A 2BTZA 1X91A 3R7KA 5M4KA 2EBHX 2E80A 2JBTA 3BNGA 2WBIA 2VF1A 3GM6A 3II9A 5J6AA 3OIBA 1SIQA 1FS9A 1K93A 1XFUA 4HR3A 3UU9A 1IS2A 2REHA 3OWMA 3SWOA 3BNHA 2R02A 4Q5BA 2C0UA 3MKHA 4W9UA 2C12A 4JIOA 4QICA 1XFYA 5K3IA 3Q0AA 4L3XA 4FF1A 1S26A 3TORA 2BU8A 4RM7A 2Q8FA 3X0YA 4E02A 1X8ZA 2AZEA 1ZOTA 1GU6A 2BU7A 3HWCA 3D9FA 4M9AA 4JIZA 1XFZA 3SXQA 1UDYA 1PI1A 3PFDA 4Q4UA 5K3JA 4AKHA 3UBRA 3VKGA 4IRNA 3LG1A 1GKXA 3OWAA 3D9GA 4JEKA 2E81A 1FS7A 4U83A 2DDHA 4F0XA 2E0AA 3Q22A 4FF2A 2CJ5A 3VADA 2EC5A 2CJ6A 2GBBA 2RF7A 5BRKA 3C2PA 1SC5A 2IX5A 4P13A 3N0RA 4DOYA 4L1FA 4LQSB 4MP2A 4J1VA 3GNCA 1RJ4A 2A1TA 2PO4A 1EGCA 2FONA 2LFWA 3MMOA 1XG2B 2XS1A 2Z1QA 4L3ZA 4N5FA 3TTBA 4HKSA 1PK0A 1SIRA 1XFWA 2QR4A 3TZ5A 3D9EA 5B5WA 3MPIA 5B5VA 3X0XA 2DVLA 4KS9A 3KMLA 4MPEA 1EGEA 2OJQA 4IV6A 2BU2A 4G97A 1LVCA 1RJ1A 2OEXA 4FZ4A 5J71A 3MDEA 3D6BA 1SK6A 2ZDXA 4AKGA 1UKWA 2AO2A 2CJ4A 5M4NA 3MXLA 3TZ2A 5K3GA 3BNJA 2CJ8A 2FP2A 2VR0A 1K8TA 4MP7A 4E00A 4AKIA 4P79A 2J7AA 2XS8A 3AFEA 3SCEA 2OT4A 4MPNA 1GKZA 4DZYA 2FP1A 2ZAFA 4XVXA 1Y0VA 2CJ7A 3NF4A 4Q5CA
chains in the Genus database with same CATH topology
3N0RA 2F6LA 1YRUA 2COLA 1K93A 1XFUA 2PO4A 1XFVA 2LFWA 4KSFA 3Q22A 4HKSA 1PK0A 1RP3A 1XFWA 2EBFX 2QR4A 3Q0AA 4QICA 1XFYA 4FF1A 4KS9A 3KMLA 1S26A 4KSAA 3Q23A 1YRTA 1ZOTA 4HKRA 4G97A 2AZEA 1LVCA 5GJWE 3C46A 1XFXA 3X29A 1XFZA 4FZ4A 4AKHA 3Q24A 4AKGA 1SK6A 3VKHA 3CE2A 2YGWA 5GJVE 2AO2A 3VKGA 4FF2A 4F0XA 4AKIA 2FP2A 1K8TA 4AI6A 2EC5A 2GBBA 4P79A 3C3LA 2EBHX 4FF3A 1K90A 3C2PA 2FP1A 4FF4A 1Y0VA 1SC5A 2VF1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PK0 A;  1LVC A;  1XFW A;  1K8T A;  1XFY A;  1XFX A;  1XFZ A;  1YRU A;  2COL A;  1K93 A;  1K90 A;  1S26 A;  1SK6 A;  1XFU A;  1XFV A;  1YRT A;  1Y0V A;  1ZOT A; 
#chains in the Genus database with same CATH topology
 2EBA A;  2OR0 A;  2Q8H A;  2R0M A;  2RFQ A;  3F29 A;  2F6L A;  3MPJ A;  2Q8I A;  1YRU A;  5BRM A;  2R05 A;  1OAH A;  1XFV A;  1U8V A;  1QDB A;  2YYI A;  4H7Q A;  4ZXV A;  1RP3 A;  2YYM A;  2BU5 A;  2XQR B;  2YYJ A;  2HJN A;  2ZO5 A;  2UXW A;  3FCJ A;  4O5M A;  3BNF A;  2RDZ A;  3S7W A;  3SF6 A;  3D1I A;  4KSA A;  2PNR A;  4Q0T A;  3Q23 A;  1T9G A;  1YRT A;  2BU6 A;  3GQT A;  2YYK A;  3X29 A;  3CRL A;  3CE2 A;  2JIF A;  3LGQ A;  3M9V A;  3RKH A;  1JM6 A;  5K3H A;  2JBS A;  4L38 A;  1Y8N A;  1Y8P A;  3CRK A;  4AI6 A;  3C3L A;  1Y8O A;  3P4T A;  4FF3 A;  1K90 A;  4MPC A;  4FF4 A;  4H85 A;  2VIG A;  1BUC A;  2ZKJ A;  4X28 A;  4X28 C;  5B6B A;  5M4P A;  2COL A;  2IX6 A;  3EOM A;  1FS8 A;  2OEV A;  4KSF A;  3FO3 A;  4H81 A;  4V26 A;  4WJY A;  3MDD A;  3TZ0 A;  1EGD A;  1GJV A;  2D29 A;  1RX0 A;  2EBF X;  2R0N A;  2R03 A;  3D2R A;  2YYG A;  2ZDY A;  2Q8G A;  4ZYJ A;  1R3B A;  1IVH A;  1W07 A;  2JBR A;  4G5E A;  4KCF A;  3TZ4 A;  5M4M A;  4HKR A;  5GJW E;  4E01 A;  3EON A;  3C46 A;  1XFX A;  4L3Y A;  1JQI A;  2YYL A;  4Q17 A;  2PG0 A;  3Q24 A;  3VKH A;  3AFF A;  5GJV E;  2YGW A;  4OO2 A;  4NXL A;  1R2J A;  1WS9 A;  3L1T A;  3D9D A;  4KTO A;  4LQQ B;  4Q1O A;  4V25 A;  2CX9 A;  1X90 A;  3B96 A;  2BTZ A;  1X91 A;  3R7K A;  5M4K A;  2EBH X;  2E80 A;  2JBT A;  3BNG A;  2WBI A;  2VF1 A;  3GM6 A;  3II9 A;  5J6A A;  3OIB A;  1SIQ A;  1FS9 A;  1K93 A;  1XFU A;  4HR3 A;  3UU9 A;  1IS2 A;  2REH A;  3OWM A;  3SWO A;  3BNH A;  2R02 A;  4Q5B A;  2C0U A;  3MKH A;  4W9U A;  2C12 A;  4JIO A;  4QIC A;  1XFY A;  5K3I A;  3Q0A A;  4L3X A;  4FF1 A;  1S26 A;  3TOR A;  2BU8 A;  4RM7 A;  2Q8F A;  3X0Y A;  4E02 A;  1X8Z A;  2AZE A;  1ZOT A;  1GU6 A;  2BU7 A;  3HWC A;  3D9F A;  4M9A A;  4JIZ A;  1XFZ A;  3SXQ A;  1UDY A;  1PI1 A;  3PFD A;  4Q4U A;  5K3J A;  4AKH A;  3UBR A;  3VKG A;  4IRN A;  3LG1 A;  1GKX A;  3OWA A;  3D9G A;  4JEK A;  2E81 A;  1FS7 A;  4U83 A;  2DDH A;  4F0X A;  2E0A A;  3Q22 A;  4FF2 A;  2CJ5 A;  3VAD A;  2EC5 A;  2CJ6 A;  2GBB A;  2RF7 A;  5BRK A;  3C2P A;  1SC5 A;  2IX5 A;  4P13 A;  3N0R A;  4DOY A;  4L1F A;  4LQS B;  4MP2 A;  4J1V A;  3GNC A;  1RJ4 A;  2A1T A;  2PO4 A;  1EGC A;  2FON A;  2LFW A;  3MMO A;  1XG2 B;  2XS1 A;  2Z1Q A;  4L3Z A;  4N5F A;  3TTB A;  4HKS A;  1PK0 A;  1SIR A;  1XFW A;  2QR4 A;  3TZ5 A;  3D9E A;  5B5W A;  3MPI A;  5B5V A;  3X0X A;  2DVL A;  4KS9 A;  3KML A;  4MPE A;  1EGE A;  2OJQ A;  4IV6 A;  2BU2 A;  4G97 A;  1LVC A;  1RJ1 A;  2OEX A;  4FZ4 A;  5J71 A;  3MDE A;  3D6B A;  1SK6 A;  2ZDX A;  4AKG A;  1UKW A;  2AO2 A;  2CJ4 A;  5M4N A;  3MXL A;  3TZ2 A;  5K3G A;  3BNJ A;  2CJ8 A;  2FP2 A;  2VR0 A;  1K8T A;  4MP7 A;  4E00 A;  4AKI A;  4P79 A;  2J7A A;  2XS8 A;  3AFE A;  3SCE A;  2OT4 A;  4MPN A;  1GKZ A;  4DZY A;  2FP1 A;  2ZAF A;  4XVX A;  1Y0V A;  2CJ7 A;  3NF4 A;  4Q5C A; 
#chains in the Genus database with same CATH homology
 3N0R A;  2F6L A;  1YRU A;  2COL A;  1K93 A;  1XFU A;  2PO4 A;  1XFV A;  2LFW A;  4KSF A;  3Q22 A;  4HKS A;  1PK0 A;  1RP3 A;  1XFW A;  2EBF X;  2QR4 A;  3Q0A A;  4QIC A;  1XFY A;  4FF1 A;  4KS9 A;  3KML A;  1S26 A;  4KSA A;  3Q23 A;  1YRT A;  1ZOT A;  4HKR A;  4G97 A;  2AZE A;  1LVC A;  5GJW E;  3C46 A;  1XFX A;  3X29 A;  1XFZ A;  4FZ4 A;  4AKH A;  3Q24 A;  4AKG A;  1SK6 A;  3VKH A;  3CE2 A;  2YGW A;  5GJV E;  2AO2 A;  3VKG A;  4FF2 A;  4F0X A;  4AKI A;  2FP2 A;  1K8T A;  4AI6 A;  2EC5 A;  2GBB A;  4P79 A;  3C3L A;  2EBH X;  4FF3 A;  1K90 A;  3C2P A;  2FP1 A;  4FF4 A;  1Y0V A;  1SC5 A;  2VF1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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