1KH7A

E. coli alkaline phosphatase mutant (d153gd330n)
Total Genus 151
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSKTSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords alkaline phosphatase
total genus 151
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh7A00
3NKNA 1ALIA 3NKQA 3UN3A 5GOVA 2GSNA 4LRAA 2RH6A 2W5WA 2ANHA 4UPIA 4ZG7A 1Y6VA 4ZG9A 2W5XA 1ED8A 3UO0A 1ED9A 1URAA 3DYCA 5IJQA 1E33P 1B8JA 1KHNA 1HQAA 3WAXA 1ELXA 3MK0A 5L0BA 2W8DA 3A52A 5EGEA 5DLWA 1N2KA 1URBA 4FDJA 5C66A 4GTZA 4KAVA 1ALKA 1O98A 1AJAA 3BDFA 5LRNA 3T02A 3T01A 3M8YA 2W5RA 3IDDA 3NKRA 1KH7A 2W8SA 2VQRA 3ED4A 4CYSA 4UPKA 3SZZA 3M8WA 2QZUA 4KJGA 4NWXA 3UN2A 4ZG6A 4UOOA 4LRFA 4CXUA 1FSUA 1K7HA 5AJ9A 4LRBA 3UNYA 4CYRA 5GRRA 3WBHA 1HJKA 3WAVA 4GTYA 3WAWA 5IJSA 3BDGA 1ELZA 3Q3QA 1AJDA 1O99A 2G9YA 4KJDA 4CXKA 1ANIA 5KXAA 4B56A 1AJBA 3BDHA 4YR1A 1Y7AA 1EJJA 3IGZB 4TN0A 4LRCA 3T00A 3BDGB 2GA3A 3DPCA 4LR2A 4UPLA 2ZKTA 3NKPA 2XRGA 2W5VA 5LIAA 4GTXA 1KHKA 4UOPA 2XR9A 3MK1A 1N2LA 2W5TA 2GSUA 1ALHA 4NWJA 1ZEFA 1E1ZP 2IUCA 2IFYA 3NKOA 4LR7A 3UN5A 1HDHA 1KH4A 4FDIA 4ZGAA 1ALJA 4GTWA 1EW9A 3E2DA 2W5SA 3M7VA 4LR8A 3NVLA 3MK2A 3IGYB 4MHXA 3B5QA 4UPHA 1AUKA 1ELYA 1KH5A 2W5QA 2IUCB 4MY4A 4QAXA 4UORA 1P49A 1EW2A 3WAYA 1E3CP 2D1GA 1ZEDA 1ANJA 4CXSA 4KM4A 5K4PA 3TX0A 3KD8A 4LRDA 1KHJA 4LR9A 1ZEBA 2GSOA 1KHLA 4LREA 4LQYA 1EI6A 1EW8A 3M8ZA 2GLQA 1SHQA 5TJ3A 3NKMA 3TG0A 5DLTA 4N7TA 3OT9A 5INHA 2X98A 5L0KA 1AJCA 3LXQA 5HRTA 1KH9A 5DLVA 4KAYA 1EQJA 1E2SP 5LRMA 3TWZA 4MIVA 3CMRA 3SZYA 5EGHA 5L0EA 5LQQA 1SHNA
chains in the Genus database with same CATH superfamily
3NKNA 1ALIA 3NKQA 3UN3A 5GOVA 2GSNA 4LRAA 2RH6A 2W5WA 2ANHA 4UPIA 4ZG7A 1Y6VA 4ZG9A 2W5XA 1ED8A 3UO0A 1ED9A 1URAA 3DYCA 5IJQA 1E33P 1B8JA 1KHNA 1HQAA 3WAXA 1ELXA 3MK0A 5L0BA 2W8DA 3A52A 5EGEA 5DLWA 1N2KA 1URBA 4FDJA 5C66A 4GTZA 4KAVA 1ALKA 1O98A 1AJAA 3BDFA 5LRNA 3T02A 3T01A 3M8YA 2W5RA 3IDDA 3NKRA 1KH7A 2W8SA 2VQRA 3ED4A 4CYSA 4UPKA 3SZZA 3M8WA 2QZUA 4KJGA 4NWXA 3UN2A 4ZG6A 4UOOA 4LRFA 4CXUA 1FSUA 1K7HA 5AJ9A 4LRBA 3UNYA 4CYRA 5GRRA 3WBHA 1HJKA 3WAVA 4GTYA 3WAWA 5IJSA 3BDGA 1ELZA 3Q3QA 1AJDA 1O99A 2G9YA 4KJDA 4CXKA 1ANIA 5KXAA 4B56A 1AJBA 3BDHA 4YR1A 1Y7AA 1EJJA 3IGZB 4TN0A 4LRCA 3T00A 3BDGB 2GA3A 3DPCA 4LR2A 4UPLA 2ZKTA 3NKPA 2XRGA 2W5VA 5LIAA 4GTXA 1KHKA 4UOPA 2XR9A 3MK1A 1N2LA 2W5TA 2GSUA 1ALHA 4NWJA 1ZEFA 1E1ZP 2IUCA 2IFYA 3NKOA 4LR7A 3UN5A 1HDHA 1KH4A 4FDIA 4ZGAA 1ALJA 4GTWA 1EW9A 3E2DA 2W5SA 3M7VA 4LR8A 3NVLA 3MK2A 3IGYB 4MHXA 3B5QA 4UPHA 1AUKA 1ELYA 1KH5A 2W5QA 2IUCB 4MY4A 4QAXA 4UORA 1P49A 1EW2A 3WAYA 1E3CP 2D1GA 1ZEDA 1ANJA 4CXSA 4KM4A 5K4PA 3TX0A 3KD8A 4LRDA 1KHJA 4LR9A 1ZEBA 2GSOA 1KHLA 4LREA 4LQYA 1EI6A 1EW8A 3M8ZA 2GLQA 1SHQA 5TJ3A 3NKMA 3TG0A 5DLTA 4N7TA 3OT9A 5INHA 2X98A 5L0KA 1AJCA 3LXQA 5HRTA 1KH9A 5DLVA 4KAYA 1EQJA 1E2SP 5LRMA 3TWZA 4MIVA 3CMRA 3SZYA 5EGHA 5L0EA 5LQQA 1SHNA
chains in the Genus database with same CATH topology
3NKNA 1ALIA 3NKQA 3UN3A 5GOVA 2GSNA 4LRAA 2RH6A 2W5WA 2ANHA 4UPIA 4ZG7A 1Y6VA 4ZG9A 2W5XA 1ED8A 3UO0A 1ED9A 1URAA 3DYCA 5IJQA 1E33P 1B8JA 1KHNA 1HQAA 3WAXA 1ELXA 3MK0A 5L0BA 2W8DA 3A52A 5EGEA 5DLWA 1N2KA 1URBA 4FDJA 5C66A 4GTZA 4KAVA 1ALKA 1O98A 1AJAA 3BDFA 5LRNA 3T02A 3T01A 3M8YA 2W5RA 3IDDA 3NKRA 1KH7A 2W8SA 2VQRA 3ED4A 4CYSA 4UPKA 3SZZA 3M8WA 2QZUA 4KJGA 4NWXA 3UN2A 4ZG6A 4UOOA 4LRFA 4CXUA 1FSUA 1K7HA 5AJ9A 4LRBA 3UNYA 4CYRA 5GRRA 3WBHA 1HJKA 3WAVA 4GTYA 3WAWA 5IJSA 3BDGA 1ELZA 3Q3QA 1AJDA 1O99A 2G9YA 4KJDA 4CXKA 1ANIA 5KXAA 4B56A 1AJBA 3BDHA 4YR1A 1Y7AA 1EJJA 3IGZB 4TN0A 4LRCA 3T00A 3BDGB 2GA3A 3DPCA 4LR2A 4UPLA 2ZKTA 3NKPA 2XRGA 2W5VA 5LIAA 4GTXA 1KHKA 4UOPA 2XR9A 3MK1A 1N2LA 2W5TA 2GSUA 1ALHA 4NWJA 1ZEFA 1E1ZP 2IUCA 2IFYA 3NKOA 4LR7A 3UN5A 1HDHA 1KH4A 4FDIA 4ZGAA 1ALJA 4GTWA 1EW9A 3E2DA 2W5SA 3M7VA 4LR8A 3NVLA 3MK2A 3IGYB 4MHXA 3B5QA 4UPHA 1AUKA 1ELYA 1KH5A 2W5QA 2IUCB 4MY4A 4QAXA 4UORA 1P49A 1EW2A 3WAYA 1E3CP 2D1GA 1ZEDA 1ANJA 4CXSA 4KM4A 5K4PA 3TX0A 3KD8A 4LRDA 1KHJA 4LR9A 1ZEBA 2GSOA 1KHLA 4LREA 4LQYA 1EI6A 1EW8A 3M8ZA 2GLQA 1SHQA 5TJ3A 3NKMA 3TG0A 5DLTA 4N7TA 3OT9A 5INHA 2X98A 5L0KA 1AJCA 3LXQA 5HRTA 1KH9A 5DLVA 4KAYA 1EQJA 1E2SP 5LRMA 3TWZA 4MIVA 3CMRA 3SZYA 5EGHA 5L0EA 5LQQA 1SHNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NKN A;  1ALI A;  3NKQ A;  3UN3 A;  5GOV A;  2GSN A;  4LRA A;  2RH6 A;  2W5W A;  2ANH A;  4UPI A;  4ZG7 A;  1Y6V A;  4ZG9 A;  2W5X A;  1ED8 A;  3UO0 A;  1ED9 A;  1URA A;  3DYC A;  5IJQ A;  1E33 P;  1B8J A;  1KHN A;  1HQA A;  3WAX A;  1ELX A;  3MK0 A;  5L0B A;  2W8D A;  3A52 A;  5EGE A;  5DLW A;  1N2K A;  1URB A;  4FDJ A;  5C66 A;  4GTZ A;  4KAV A;  1ALK A;  1O98 A;  1AJA A;  3BDF A;  5LRN A;  3T02 A;  3T01 A;  3M8Y A;  2W5R A;  3IDD A;  3NKR A;  1KH7 A;  2W8S A;  2VQR A;  3ED4 A;  4CYS A;  4UPK A;  3SZZ A;  3M8W A;  2QZU A;  4KJG A;  4NWX A;  3UN2 A;  4ZG6 A;  4UOO A;  4LRF A;  4CXU A;  1FSU A;  1K7H A;  5AJ9 A;  4LRB A;  3UNY A;  4CYR A;  5GRR A;  3WBH A;  1HJK A;  3WAV A;  4GTY A;  3WAW A;  5IJS A;  3BDG A;  1ELZ A;  3Q3Q A;  1AJD A;  1O99 A;  2G9Y A;  4KJD A;  4CXK A;  1ANI A;  5KXA A;  4B56 A;  1AJB A;  3BDH A;  4YR1 A;  1Y7A A;  1EJJ A;  3IGZ B;  4TN0 A;  4LRC A;  3T00 A;  3BDG B;  2GA3 A;  3DPC A;  4LR2 A;  4UPL A;  2ZKT A;  3NKP A;  2XRG A;  2W5V A;  5LIA A;  4GTX A;  1KHK A;  4UOP A;  2XR9 A;  3MK1 A;  1N2L A;  2W5T A;  2GSU A;  1ALH A;  4NWJ A;  1ZEF A;  1E1Z P;  2IUC A;  2IFY A;  3NKO A;  4LR7 A;  3UN5 A;  1HDH A;  1KH4 A;  4FDI A;  4ZGA A;  1ALJ A;  4GTW A;  1EW9 A;  3E2D A;  2W5S A;  3M7V A;  4LR8 A;  3NVL A;  3MK2 A;  3IGY B;  4MHX A;  3B5Q A;  4UPH A;  1AUK A;  1ELY A;  1KH5 A;  2W5Q A;  2IUC B;  4MY4 A;  4QAX A;  4UOR A;  1P49 A;  1EW2 A;  3WAY A;  1E3C P;  2D1G A;  1ZED A;  1ANJ A;  4CXS A;  4KM4 A;  5K4P A;  3TX0 A;  3KD8 A;  4LRD A;  1KHJ A;  4LR9 A;  1ZEB A;  2GSO A;  1KHL A;  4LRE A;  4LQY A;  1EI6 A;  1EW8 A;  3M8Z A;  2GLQ A;  1SHQ A;  5TJ3 A;  3NKM A;  3TG0 A;  5DLT A;  4N7T A;  3OT9 A;  5INH A;  2X98 A;  5L0K A;  1AJC A;  3LXQ A;  5HRT A;  1KH9 A;  5DLV A;  4KAY A;  1EQJ A;  1E2S P;  5LRM A;  3TWZ A;  4MIV A;  3CMR A;  3SZY A;  5EGH A;  5L0E A;  5LQQ A;  1SHN A; 
#chains in the Genus database with same CATH topology
 3NKN A;  1ALI A;  3NKQ A;  3UN3 A;  5GOV A;  2GSN A;  4LRA A;  2RH6 A;  2W5W A;  2ANH A;  4UPI A;  4ZG7 A;  1Y6V A;  4ZG9 A;  2W5X A;  1ED8 A;  3UO0 A;  1ED9 A;  1URA A;  3DYC A;  5IJQ A;  1E33 P;  1B8J A;  1KHN A;  1HQA A;  3WAX A;  1ELX A;  3MK0 A;  5L0B A;  2W8D A;  3A52 A;  5EGE A;  5DLW A;  1N2K A;  1URB A;  4FDJ A;  5C66 A;  4GTZ A;  4KAV A;  1ALK A;  1O98 A;  1AJA A;  3BDF A;  5LRN A;  3T02 A;  3T01 A;  3M8Y A;  2W5R A;  3IDD A;  3NKR A;  1KH7 A;  2W8S A;  2VQR A;  3ED4 A;  4CYS A;  4UPK A;  3SZZ A;  3M8W A;  2QZU A;  4KJG A;  4NWX A;  3UN2 A;  4ZG6 A;  4UOO A;  4LRF A;  4CXU A;  1FSU A;  1K7H A;  5AJ9 A;  4LRB A;  3UNY A;  4CYR A;  5GRR A;  3WBH A;  1HJK A;  3WAV A;  4GTY A;  3WAW A;  5IJS A;  3BDG A;  1ELZ A;  3Q3Q A;  1AJD A;  1O99 A;  2G9Y A;  4KJD A;  4CXK A;  1ANI A;  5KXA A;  4B56 A;  1AJB A;  3BDH A;  4YR1 A;  1Y7A A;  1EJJ A;  3IGZ B;  4TN0 A;  4LRC A;  3T00 A;  3BDG B;  2GA3 A;  3DPC A;  4LR2 A;  4UPL A;  2ZKT A;  3NKP A;  2XRG A;  2W5V A;  5LIA A;  4GTX A;  1KHK A;  4UOP A;  2XR9 A;  3MK1 A;  1N2L A;  2W5T A;  2GSU A;  1ALH A;  4NWJ A;  1ZEF A;  1E1Z P;  2IUC A;  2IFY A;  3NKO A;  4LR7 A;  3UN5 A;  1HDH A;  1KH4 A;  4FDI A;  4ZGA A;  1ALJ A;  4GTW A;  1EW9 A;  3E2D A;  2W5S A;  3M7V A;  4LR8 A;  3NVL A;  3MK2 A;  3IGY B;  4MHX A;  3B5Q A;  4UPH A;  1AUK A;  1ELY A;  1KH5 A;  2W5Q A;  2IUC B;  4MY4 A;  4QAX A;  4UOR A;  1P49 A;  1EW2 A;  3WAY A;  1E3C P;  2D1G A;  1ZED A;  1ANJ A;  4CXS A;  4KM4 A;  5K4P A;  3TX0 A;  3KD8 A;  4LRD A;  1KHJ A;  4LR9 A;  1ZEB A;  2GSO A;  1KHL A;  4LRE A;  4LQY A;  1EI6 A;  1EW8 A;  3M8Z A;  2GLQ A;  1SHQ A;  5TJ3 A;  3NKM A;  3TG0 A;  5DLT A;  4N7T A;  3OT9 A;  5INH A;  2X98 A;  5L0K A;  1AJC A;  3LXQ A;  5HRT A;  1KH9 A;  5DLV A;  4KAY A;  1EQJ A;  1E2S P;  5LRM A;  3TWZ A;  4MIV A;  3CMR A;  3SZY A;  5EGH A;  5L0E A;  5LQQ A;  1SHN A; 
#chains in the Genus database with same CATH homology
 3NKN A;  1ALI A;  3NKQ A;  3UN3 A;  5GOV A;  2GSN A;  4LRA A;  2RH6 A;  2W5W A;  2ANH A;  4UPI A;  4ZG7 A;  1Y6V A;  4ZG9 A;  2W5X A;  1ED8 A;  3UO0 A;  1ED9 A;  1URA A;  3DYC A;  5IJQ A;  1E33 P;  1B8J A;  1KHN A;  1HQA A;  3WAX A;  1ELX A;  3MK0 A;  5L0B A;  2W8D A;  3A52 A;  5EGE A;  5DLW A;  1N2K A;  1URB A;  4FDJ A;  5C66 A;  4GTZ A;  4KAV A;  1ALK A;  1O98 A;  1AJA A;  3BDF A;  5LRN A;  3T02 A;  3T01 A;  3M8Y A;  2W5R A;  3IDD A;  3NKR A;  1KH7 A;  2W8S A;  2VQR A;  3ED4 A;  4CYS A;  4UPK A;  3SZZ A;  3M8W A;  2QZU A;  4KJG A;  4NWX A;  3UN2 A;  4ZG6 A;  4UOO A;  4LRF A;  4CXU A;  1FSU A;  1K7H A;  5AJ9 A;  4LRB A;  3UNY A;  4CYR A;  5GRR A;  3WBH A;  1HJK A;  3WAV A;  4GTY A;  3WAW A;  5IJS A;  3BDG A;  1ELZ A;  3Q3Q A;  1AJD A;  1O99 A;  2G9Y A;  4KJD A;  4CXK A;  1ANI A;  5KXA A;  4B56 A;  1AJB A;  3BDH A;  4YR1 A;  1Y7A A;  1EJJ A;  3IGZ B;  4TN0 A;  4LRC A;  3T00 A;  3BDG B;  2GA3 A;  3DPC A;  4LR2 A;  4UPL A;  2ZKT A;  3NKP A;  2XRG A;  2W5V A;  5LIA A;  4GTX A;  1KHK A;  4UOP A;  2XR9 A;  3MK1 A;  1N2L A;  2W5T A;  2GSU A;  1ALH A;  4NWJ A;  1ZEF A;  1E1Z P;  2IUC A;  2IFY A;  3NKO A;  4LR7 A;  3UN5 A;  1HDH A;  1KH4 A;  4FDI A;  4ZGA A;  1ALJ A;  4GTW A;  1EW9 A;  3E2D A;  2W5S A;  3M7V A;  4LR8 A;  3NVL A;  3MK2 A;  3IGY B;  4MHX A;  3B5Q A;  4UPH A;  1AUK A;  1ELY A;  1KH5 A;  2W5Q A;  2IUC B;  4MY4 A;  4QAX A;  4UOR A;  1P49 A;  1EW2 A;  3WAY A;  1E3C P;  2D1G A;  1ZED A;  1ANJ A;  4CXS A;  4KM4 A;  5K4P A;  3TX0 A;  3KD8 A;  4LRD A;  1KHJ A;  4LR9 A;  1ZEB A;  2GSO A;  1KHL A;  4LRE A;  4LQY A;  1EI6 A;  1EW8 A;  3M8Z A;  2GLQ A;  1SHQ A;  5TJ3 A;  3NKM A;  3TG0 A;  5DLT A;  4N7T A;  3OT9 A;  5INH A;  2X98 A;  5L0K A;  1AJC A;  3LXQ A;  5HRT A;  1KH9 A;  5DLV A;  4KAY A;  1EQJ A;  1E2S P;  5LRM A;  3TWZ A;  4MIV A;  3CMR A;  3SZY A;  5EGH A;  5L0E A;  5LQQ A;  1SHN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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